Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BVES	11149	broad.mit.edu	37	6	105573444	105573444	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:105573444C>T	ENST00000314641.5	-	4	577	c.361G>A	c.(361-363)Gaa>Aaa	p.E121K	BVES_ENST00000446408.2_Missense_Mutation_p.E121K|BVES_ENST00000336775.5_Missense_Mutation_p.E121K	NM_001199563.1	NP_001186492.1	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance	121					epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity			NS(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|urinary_tract(1)	21		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				AGTTCCTTTTCAATCTTTACC	0.418000													20	65					0	0	1	0	0
TAF1	6872	broad.mit.edu	37	X	70607185	70607185	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:70607185G>C	ENST00000449580.1	+	15	2349	c.2298G>C	c.(2296-2298)cgG>cgC	p.R766R	TAF1_ENST00000276072.3_Silent_p.R787R|TAF1_ENST00000373790.4_Silent_p.R766R|TAF1_ENST00000423759.1_Silent_p.R787R			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	766					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				TGATCATTCGGACAAGACAGG	0.393000													41	76					0	0	1	0	0
LRP8	7804	broad.mit.edu	37	1	53732281	53732281	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:53732281C>G	ENST00000306052.6	-	9	1392	c.1291G>C	c.(1291-1293)Gag>Cag	p.E431Q	LRP8_ENST00000347547.2_Missense_Mutation_p.E261Q|LRP8_ENST00000354412.3_Missense_Mutation_p.E302Q|LRP8_ENST00000465675.1_5'UTR|LRP8_ENST00000371454.2_Missense_Mutation_p.E431Q	NM_004631.4	NP_004622.2	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	431					cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(1)	21						CTCCGCACCTCGTGCCGGTTG	0.552000													25	33					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50958429	50958429	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:50958429C>T	ENST00000357701.5	+	19	2130	c.2079C>T	c.(2077-2079)ttC>ttT	p.F693F		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	693	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		TTGAGGTCTTCACAGAGACCA	0.552000													11	29					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21331013	21331013	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:21331013C>T	ENST00000313654.9	+	5	1057	c.816C>T	c.(814-816)ctC>ctT	p.L272L	LAMA3_ENST00000399516.3_Silent_p.L272L	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	272	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTGGACACCTCATCTCCAAAG	0.418000													38	92					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60072632	60072632	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:60072632C>T	ENST00000397786.2	-	10	2138	c.2062G>A	c.(2062-2064)Gat>Aat	p.D688N		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	688					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TGTTCTGCATCAGATGCTATT	0.333000													36	87					0	0	1	0	0
ZNF724P	440519	broad.mit.edu	37	19	23415058	23415058	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:23415058G>A	ENST00000418100.1	-	2	158	c.41C>T	c.(40-42)tCt>tTt	p.S14F	ZNF724P_ENST00000597037.1_Missense_Mutation_p.S14F																endometrium(3)|kidney(1)|lung(2)|ovary(2)	8						CTCCTCCACAGAGAATTCTAT	0.413000													40	113					0	0	1	0	0
TMED4	222068	broad.mit.edu	37	7	44620677	44620677	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:44620677G>A	ENST00000481238.1	-	4	573	c.549C>T	c.(547-549)ctC>ctT	p.L183L	TMED4_ENST00000457408.2_Intron|TMED4_ENST00000289577.5_Intron			Q7Z7H5	TMED4_HUMAN	transmembrane emp24 protein transport domain containing 4	0					positive regulation of I-kappaB kinase/NF-kappaB cascade|transport	endoplasmic reticulum membrane|integral to membrane	signal transducer activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)	6						AAATTACAAGGAGATATGCAC	0.478000													13	36					0	0	1	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798826	55798826	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:55798826C>T	ENST00000313555.1	+	1	932	c.932C>T	c.(931-933)tCa>tTa	p.S311L		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					ATTGGATATTCAAATGAATGG	0.284000													27	47					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130300620	130300620	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:130300620G>C	ENST00000358511.6	+	8	3794	c.3763G>C	c.(3763-3765)Gag>Cag	p.E1255Q	COL6A6_ENST00000453409.2_Missense_Mutation_p.E1255Q	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1255	Nonhelical region.|VWFA 7.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TCCCAAGTTTGAGATCTACAG	0.423000													43	66					0	0	1	0	0
INTS4	92105	broad.mit.edu	37	11	77632406	77632406	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:77632406G>A	ENST00000534064.1	-	14	1778	c.1744C>T	c.(1744-1746)Cat>Tat	p.H582Y		NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	582					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			GGAACAAGATGAGAAAGACTG	0.413000													10	239					0	0	1	0	0
PDE12	201626	broad.mit.edu	37	3	57543266	57543266	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:57543266G>A	ENST00000311180.8	+	1	1263	c.1160G>A	c.(1159-1161)cGa>cAa	p.R387Q	PDE12_ENST00000487257.1_Missense_Mutation_p.R387Q	NM_177966.5	NP_808881.3	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	387							hydrolase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(4)|lung(3)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		ACTTTCTACCGAAAGTCTAAG	0.527000													23	30					0	0	1	0	0
CALR	811	broad.mit.edu	37	19	13051185	13051185	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:13051185G>A	ENST00000316448.5	+	5	694	c.621G>A	c.(619-621)aaG>aaA	p.K207K		NM_004343.3	NP_004334.1	P27797	CALR_HUMAN	calreticulin	207	4 X approximate repeats.|P-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(1)	10					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACCCAAGAAGATAAAGGATC	0.542000													29	21					0	0	1	0	0
LTBP3	4054	broad.mit.edu	37	11	65318931	65318931	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:65318931C>G	ENST00000301873.5	-	10	1831	c.1563G>C	c.(1561-1563)gaG>gaC	p.E521D	LTBP3_ENST00000536982.1_Missense_Mutation_p.E147D|LTBP3_ENST00000322147.4_Missense_Mutation_p.E521D	NM_001130144.2	NP_001123616.1	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding protein 3	521						extracellular region	calcium ion binding|growth factor binding	p.E521D(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						GCACTGACCTCTCCTCACTCA	0.637000													8	26					0	0	1	0	0
CBLB	868	broad.mit.edu	37	3	105464872	105464872	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:105464872G>C	ENST00000264122.4	-	6	1055	c.734C>G	c.(733-735)tCt>tGt	p.S245C	CBLB_ENST00000545639.1_3'UTR|CBLB_ENST00000403724.1_Missense_Mutation_p.S245C|CBLB_ENST00000405772.1_Missense_Mutation_p.S245C|CBLB_ENST00000394027.3_Missense_Mutation_p.S267C	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	245	Cbl-PTB.|SH2-like.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						CCGCAAAATAGAGCCCCAAGG	0.313000			Mis S		AML								20	48					0	0	1	0	0
EME1	146956	broad.mit.edu	37	17	48452684	48452684	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:48452684G>A	ENST00000393271.2	+	2	197	c.115G>A	c.(115-117)Gaa>Aaa	p.E39K	EME1_ENST00000338165.4_Missense_Mutation_p.E39K|EME1_ENST00000511648.2_Missense_Mutation_p.E39K	NM_001166131.1	NP_001159603.1	Q96AY2	EME1_HUMAN	essential meiotic structure-specific endonuclease 1	39					DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding			endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	19	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			GAGACAGCCTGAAAGGGAAGA	0.468000								Direct reversal of damage;Homologous recombination					20	38					0	0	1	0	0
TCEA2	6919	broad.mit.edu	37	20	62701763	62701763	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:62701763C>T	ENST00000361317.2	+	8	1029	c.587C>T	c.(586-588)tCa>tTa	p.S196L	TCEA2_ENST00000395053.3_3'UTR|TCEA2_ENST00000465111.1_3'UTR|TCEA2_ENST00000343484.5_Missense_Mutation_p.S223L	NM_198723.1	NP_942016.1	Q15560	TCEA2_HUMAN	transcription elongation factor A (SII), 2	223	TFIIS central.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	transcription elongation factor complex	DNA binding|protein binding|translation elongation factor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)	12	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					GTGATGACCTCAGAGGTGAGC	0.627000													8	59					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5417591	5417591	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:5417591G>A	ENST00000399537.4	-	6	2565	c.2217C>T	c.(2215-2217)ctC>ctT	p.L739L	TNRC18_ENST00000430969.1_Silent_p.L739L			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	739							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GCCGTGCCCCGAGCAGCCGTT	0.692000													12	33					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91497594	91497594	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:91497594C>T	ENST00000416354.1	+	20	3158	c.3086C>T	c.(3085-3087)tCt>tTt	p.S1029F	KIF20B_ENST00000394289.2_Missense_Mutation_p.S999F|KIF20B_ENST00000371728.3_Missense_Mutation_p.S999F|KIF20B_ENST00000260753.4_Missense_Mutation_p.S959F|KIF20B_ENST00000478929.1_3'UTR			Q96Q89	KI20B_HUMAN	kinesin family member 20B	999					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						GATTCAGTTTCTCAGATTTCA	0.333000													37	80					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13145442	13145442	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:13145442G>A	ENST00000399002.2	+	12	1861	c.1587G>A	c.(1585-1587)ctG>ctA	p.L529L		NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	529					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	TCTTGCAACTGAAATATTCCC	0.428000													9	28					0	0	1	0	0
POLR2H	5437	broad.mit.edu	37	3	184084567	184084567	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:184084567C>G	ENST00000456318.1	+	5	1363	c.314C>G	c.(313-315)tCt>tGt	p.S105C	EIF2B5_ENST00000444495.1_Intron|POLR2H_ENST00000443489.1_Intron|POLR2H_ENST00000429568.1_Missense_Mutation_p.S105C|POLR2H_ENST00000438240.1_Missense_Mutation_p.S69C|POLR2H_ENST00000430783.1_Intron|POLR2H_ENST00000452961.1_Missense_Mutation_p.S69C|POLR2H_ENST00000296223.3_Missense_Mutation_p.S105C	NM_001278699.1	NP_001265628.1	P52434	RPAB3_HUMAN	polymerase (RNA) II (DNA directed) polypeptide H	105					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA-directed RNA polymerase activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GATGAAACTTCTACTGAAGCA	0.413000													12	20					0	0	1	0	0
PIM2	11040	broad.mit.edu	37	X	48772314	48772314	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:48772314G>T	ENST00000376509.4	-	4	767	c.578C>A	c.(577-579)cCc>cAc	p.P193H		NM_006875.3	NP_006866.2	Q9P1W9	PIM2_HUMAN	pim-2 oncogene	193	Protein kinase.				anti-apoptosis|cell proliferation|male meiosis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|response to virus		ATP binding|protein serine/threonine kinase activity			lung(3)|stomach(1)	4						GTCAGTGTAGGGTTCATCATG	0.493000													9	13					0.000442599	0.000447039	1	1	0
PCBP1	5093	broad.mit.edu	37	2	70315647	70315647	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:70315647G>T	ENST00000303577.5	+	1	1063	c.772G>T	c.(772-774)Gcc>Tcc	p.A258S	PCBP1-AS1_ENST00000596028.1_RNA|PCBP1-AS1_ENST00000452431.1_RNA	NM_006196.3	NP_006187.2	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	258					nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|skin(1)	12						GACCGGATTCGCCGGAATTGA	0.502000													21	44					9.57634e-11	1.00139e-10	1	1	0
ATP6V1G3	127124	broad.mit.edu	37	1	198505852	198505852	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:198505852G>C	ENST00000309309.7	-	3	190	c.85C>G	c.(85-87)Ctg>Gtg	p.L29V	ATP6V1G3_ENST00000281087.2_Intron|ATP6V1G3_ENST00000489986.1_Intron|ATP6V1G3_ENST00000367382.1_Intron|ATP6V1G3_ENST00000367381.1_Intron	NM_133326.1	NP_579872.1	Q96LB4	VATG3_HUMAN	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	0					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)	7						AGTAGATGCAGAACTTACAGC	0.333000													66	98					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28277234	28277234	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:28277234C>T	ENST00000354638.3	-	3	458	c.303G>A	c.(301-303)ctG>ctA	p.L101L	OCA2_ENST00000353809.5_Silent_p.L101L|OCA2_ENST00000382996.2_Silent_p.L101L	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	101					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AGGAATTCCTCAGCAAAGGAG	0.453000									Oculocutaneous Albinism				22	63					0	0	1	0	0
FKBP6	8468	broad.mit.edu	37	7	72744161	72744161	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:72744161C>T	ENST00000252037.4	+	4	343	c.274C>T	c.(274-276)Ctg>Ttg	p.L92L	FKBP6_ENST00000431982.2_Silent_p.L87L|FKBP6_ENST00000413573.2_Silent_p.L62L	NM_003602.3	NP_003593.3	O75344	FKBP6_HUMAN	FK506 binding protein 6, 36kDa	92	PPIase FKBP-type.				protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	16		Lung NSC(55;0.0908)|all_lung(88;0.198)				AGATATTACACTGTGGGGCAT	0.532000													3	41					0	0	1	0	0
TBC1D32	221322	broad.mit.edu	37	6	121433760	121433760	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:121433760G>A	ENST00000275159.6	-	30	3337	c.3338C>T	c.(3337-3339)tCt>tTt	p.S1113F	TBC1D32_ENST00000398212.2_Missense_Mutation_p.S1072F|TBC1D32_ENST00000398197.2_5'UTR					TBC1 domain family, member 32																		CATGAACAGAGAAGATACAAA	0.348000													18	35					0	0	1	0	0
AGPAT6	137964	broad.mit.edu	37	8	41466948	41466948	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:41466948G>C	ENST00000396987.3	+	3	1106	c.179G>C	c.(178-180)aGa>aCa	p.R60T		NM_178819.3	NP_848934.1	Q86UL3	GPAT4_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 6	60					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(6)	14	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			GCTACCTTGAGAATGGAGCGA	0.498000													14	16					0	0	1	0	0
TRIP13	9319	broad.mit.edu	37	5	896858	896858	+	Missense_Mutation	SNP	G	G	C	rs149813610		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:896858G>C	ENST00000166345.3	+	3	693	c.337G>C	c.(337-339)Gag>Cag	p.E113Q		NM_004237.3	NP_004228.1	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	113					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	18			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			TGAAAATCTGGAGGAAGAGAC	0.473000													17	43					0	0	1	0	0
TRAPPC8	22878	broad.mit.edu	37	18	29493399	29493399	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:29493399C>G	ENST00000283351.4	-	5	1039	c.704G>C	c.(703-705)cGa>cCa	p.R235P	TRAPPC8_ENST00000582513.1_Missense_Mutation_p.R235P|TRAPPC8_ENST00000582539.1_Missense_Mutation_p.R181P	NM_014939.3	NP_055754	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	235					ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ATCTGATGCTCGATTAGATGT	0.313000													24	47					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106704887	106704887	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:106704887G>C	ENST00000546625.1	+	2	193	c.34G>C	c.(34-36)Gag>Cag	p.E12Q	TCP11L2_ENST00000547153.1_Missense_Mutation_p.E12Q|TCP11L2_ENST00000299045.3_Missense_Mutation_p.E12Q			Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	12										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						GTGTGTGGGAGAGGACCAGCC	0.507000													10	58					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139163459	139163459	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:139163459C>T	ENST00000395297.1	-	13	3429	c.3259G>A	c.(3259-3261)Gaa>Aaa	p.E1087K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1087										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCACTGACTTCCTCATCCAAC	0.463000										HNSCC(54;0.14)			4	35					0	0	1	0	0
ATP6V1G3	127124	broad.mit.edu	37	1	198492553	198492553	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:198492553C>T	ENST00000367381.1	-	5	448	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	ATP6V1G3_ENST00000281087.2_Missense_Mutation_p.E109K|ATP6V1G3_ENST00000309309.7_3'UTR|ATP6V1G3_ENST00000489986.1_Missense_Mutation_p.E115K|ATP6V1G3_ENST00000367382.1_Missense_Mutation_p.E109K			Q96LB4	VATG3_HUMAN	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	109					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)	7						ACATGGATTTCTGGTTTCATG	0.398000													14	63					0	0	1	0	0
STRADB	55437	broad.mit.edu	37	2	202340361	202340361	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:202340361G>C	ENST00000194530.3	+	7	809	c.444G>C	c.(442-444)ttG>ttC	p.L148F	STRADB_ENST00000392249.2_Missense_Mutation_p.L148F	NM_001206864.1|NM_018571.5	NP_001193793.1|NP_061041.2	Q9C0K7	STRAB_HUMAN	STE20-related kinase adaptor beta	148	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|protein binding|protein kinase activity			breast(1)|large_intestine(2)|lung(5)|prostate(1)|skin(3)|stomach(1)	13						GTCAACTCTTGAGGACCTATT	0.378000													41	80					0	0	1	0	0
CNTLN	54875	broad.mit.edu	37	9	17340840	17340840	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:17340840G>A	ENST00000380647.3	+	11	1744	c.1660G>A	c.(1660-1662)Gag>Aag	p.E554K	CNTLN_ENST00000425824.1_Missense_Mutation_p.E554K|CNTLN_ENST00000262360.5_Missense_Mutation_p.E554K			Q9NXG0	CNTLN_HUMAN	centlein, centrosomal protein	554						centriole|membrane	two-component sensor activity			breast(6)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53				GBM - Glioblastoma multiforme(50;6.14e-10)		AGAAAATGATGAGCTAAGAGA	0.348000													51	22					0	0	1	0	0
EML4	27436	broad.mit.edu	37	2	42543133	42543133	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:42543133C>T	ENST00000318522.5	+	18	2261	c.1999C>T	c.(1999-2001)Cta>Tta	p.L667L	EML4_ENST00000401738.3_Silent_p.L678L|EML4_ENST00000453191.2_Intron|EML4_ENST00000402711.2_Silent_p.L609L	NM_019063.3	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	667					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						AACCAGAGATCTAGTTTCTAT	0.383000			T	ALK	NSCLC								28	67					0	0	1	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	159604002	159604002	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:159604002G>C	ENST00000337808.6	+	4	1462	c.885G>C	c.(883-885)caG>caC	p.Q295H	SCHIP1_ENST00000482804.1_Missense_Mutation_p.Q68H|IQCJ-SCHIP1_ENST00000412423.2_Missense_Mutation_p.Q282H|IQCJ-SCHIP1_ENST00000460298.1_Missense_Mutation_p.Q255H|IQCJ-SCHIP1_ENST00000485419.1_Missense_Mutation_p.Q371H|IQCJ-SCHIP1_ENST00000527095.1_Missense_Mutation_p.Q63H|IQCJ-SCHIP1_ENST00000476809.1_Missense_Mutation_p.Q344H|SCHIP1_ENST00000445224.2_Missense_Mutation_p.Q52H	NM_001197107.1|NM_014575.3	NP_001184036.1|NP_055390.1	Q9P0W5	SCHI1_HUMAN		295						cytoplasm	identical protein binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						CCAGACTGCAGAGTGGGATGA	0.443000													20	46					0	0	1	0	0
AGPAT6	137964	broad.mit.edu	37	8	41466953	41466953	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:41466953G>T	ENST00000396987.3	+	3	1111	c.184G>T	c.(184-186)Gag>Tag	p.E62*		NM_178819.3	NP_848934.1	Q86UL3	GPAT4_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 6	62					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(6)	14	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			CTTGAGAATGGAGCGAGGAGC	0.493000													13	15					9.31168e-06	9.47158e-06	1	1	0
IPCEF1	26034	broad.mit.edu	37	6	154533943	154533943	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:154533943C>T	ENST00000265198.4	-	9	650	c.495G>A	c.(493-495)gaG>gaA	p.E165E	IPCEF1_ENST00000519344.1_Silent_p.E137E|IPCEF1_ENST00000367220.4_Silent_p.E166E|IPCEF1_ENST00000422970.2_Silent_p.E166E|IPCEF1_ENST00000519091.1_5'UTR|OPRM1_ENST00000337049.4_Intron	NM_001130700.1|NM_015553.2	NP_001124172.1|NP_056368.1			interaction protein for cytohesin exchange factors 1											breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	12						GGGGTGGTGTCTCCGCAGCTA	0.423000													8	37					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47125551	47125551	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:47125551C>G	ENST00000409792.3	-	12	5761	c.5719G>C	c.(5719-5721)Gag>Cag	p.E1907Q		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1907					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TCAAGATCCTCTTTGCCATCC	0.418000			"""N, F, S, Mis"""		clear cell renal carcinoma								31	198					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8376743	8376743	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:8376743C>T	ENST00000538603.1	-	5	750	c.192G>A	c.(190-192)tgG>tgA	p.W64*	FAM90A1_ENST00000307435.6_Nonsense_Mutation_p.W64*	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	64							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		GGGCTGCCTTCCAGCACTTCA	0.547000													27	161					0	0	1	0	0
SNX7	51375	broad.mit.edu	37	1	99225673	99225673	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:99225673G>C	ENST00000370189.5	+	9	1361	c.997G>C	c.(997-999)Gaa>Caa	p.E333Q	SNX7_ENST00000529992.1_Missense_Mutation_p.E393Q|SNX7_ENST00000306121.3_Missense_Mutation_p.E448Q			Q9UNH6	SNX7_HUMAN	sorting nexin 7	384					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	13		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		AGAAGCCTCTGAAGATAAACC	0.408000													8	42					0	0	1	0	0
PUM2	23369	broad.mit.edu	37	2	20508206	20508206	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:20508206C>T	ENST00000361078.2	-	5	680	c.658G>A	c.(658-660)Gaa>Aaa	p.E220K	PUM2_ENST00000319801.5_Missense_Mutation_p.E220K|PUM2_ENST00000403432.1_Missense_Mutation_p.E220K|PUM2_ENST00000338086.5_Missense_Mutation_p.E220K|PUM2_ENST00000536417.1_Missense_Mutation_p.E164K|PUM2_ENST00000420234.1_5'UTR			Q8TB72	PUM2_HUMAN	pumilio RNA-binding family member 2	220	Interaction with SNAPIN.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(7)|lung(13)|ovary(2)|prostate(4)|urinary_tract(3)	42	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCTGAGTTTCAGGATTTGAA	0.448000													33	82					0	0	1	0	0
ZAK	51776	broad.mit.edu	37	2	174125822	174125822	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:174125822G>T	ENST00000375213.3	+	18	1586	c.1508G>T	c.(1507-1509)gGa>gTa	p.G503V	MLK7-AS1_ENST00000422703.1_RNA|MLTK_ENST00000409176.2_Missense_Mutation_p.G503V|MLK7-AS1_ENST00000423106.2_RNA	NM_016653.2	NP_057737.2																					TGGATTGTAGGAATAGCAAAA	0.408000													15	39					2.89027e-11	3.02862e-11	1	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18680332	18680332	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:18680332G>A	ENST00000380548.4	+	11	1498	c.1159G>A	c.(1159-1161)Gcg>Acg	p.A387T	ADAMTSL1_ENST00000276935.6_Missense_Mutation_p.A387T|ADAMTSL1_ENST00000327883.7_Missense_Mutation_p.A387T|ADAMTSL1_ENST00000380566.4_Missense_Mutation_p.A370T	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	387	TSP type-1 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CCCATGGACCGCGTGCTCCTC	0.602000													43	13					0	0	1	0	0
KIAA1328	57536	broad.mit.edu	37	18	34740319	34740319	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:34740319G>C	ENST00000591619.1	+	8	2163	c.1377G>C	c.(1375-1377)aaG>aaC	p.K459N	KIAA1328_ENST00000280020.5_Missense_Mutation_p.K463N|KIAA1328_ENST00000586135.1_Missense_Mutation_p.K215N|KIAA1328_ENST00000435985.2_Missense_Mutation_p.K215N|KIAA1328_ENST00000543923.1_Missense_Mutation_p.K355N			Q86T90	K1328_HUMAN	KIAA1328	463										central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	14				COAD - Colon adenocarcinoma(74;0.195)		CATGTCAAAAGAAAGATACAT	0.438000													19	20					0	0	1	0	0
CLN5	1203	broad.mit.edu	37	13	77566169	77566169	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:77566169C>T	ENST00000377453.3	+	1	1375	c.83C>T	c.(82-84)cCg>cTg	p.P28L		NM_006493.2	NP_006484.1	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	0					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	16		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		CTGGCGGCTCCGCGCATGCTC	0.731000													3	11					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53576080	53576080	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:53576080G>A	ENST00000342160.3	-	66	10332	c.9875C>T	c.(9874-9876)gCa>gTa	p.A3292V	HUWE1_ENST00000262854.6_Missense_Mutation_p.A3292V			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3292					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GCCTAGGGCTGCATCCATGGA	0.537000													9	95					0	0	1	0	0
PCCB	5096	broad.mit.edu	37	3	136045706	136045706	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:136045706C>G	ENST00000471595.1	+	11	1170	c.1152C>G	c.(1150-1152)ttC>ttG	p.F384L	PCCB_ENST00000478469.1_Intron|PCCB_ENST00000469217.1_Missense_Mutation_p.F404L|PCCB_ENST00000483687.1_Missense_Mutation_p.F365L|PCCB_ENST00000466072.1_Missense_Mutation_p.F404L|PCCB_ENST00000468777.1_Missense_Mutation_p.F415L|PCCB_ENST00000482086.1_Missense_Mutation_p.F268L|PCCB_ENST00000490504.1_Missense_Mutation_p.F327L|PCCB_ENST00000474833.1_3'UTR|PCCB_ENST00000251654.4_Missense_Mutation_p.F384L|PCCB_ENST00000462637.1_Missense_Mutation_p.F361L			P05166	PCCB_HUMAN	propionyl CoA carboxylase, beta polypeptide	384	Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	25					Biotin(DB00121)|L-Valine(DB00161)	GTGATGCATTCAATATTCCAC	0.438000													47	117					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218683208	218683208	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:218683208G>A	ENST00000171887.4	-	24	3987	c.3535C>T	c.(3535-3537)Cag>Tag	p.Q1179*	TNS1_ENST00000430930.1_Nonsense_Mutation_p.Q1158*|TNS1_ENST00000419504.1_Nonsense_Mutation_p.Q1166*	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1179						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TGGCGCGCCTGAGGGCTCCCA	0.637000													18	43					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2180733	2180733	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:2180733C>T	ENST00000398665.3	+	2	139	c.103C>T	c.(103-105)Cat>Tat	p.H35Y		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	35						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGATGCTGCTCATGAAATCAT	0.557000													22	19					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56357771	56357771	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:56357771G>A	ENST00000370754.5	-	84	20417	c.20418C>T	c.(20416-20418)ctC>ctT	p.L6806L	DST_ENST00000361203.3_Silent_p.L6517L|DST_ENST00000244364.6_Silent_p.L4214L|DST_ENST00000370788.2_Silent_p.L4431L|DST_ENST00000446842.2_Silent_p.L6302L|DST_ENST00000421834.2_Silent_p.L4540L|DST_ENST00000370769.4_Silent_p.L6628L|DST_ENST00000312431.6_3'UTR			Q03001	DYST_HUMAN	dystonin	6626					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGTCCAAGATGAGACTTGGCC	0.403000													9	19					0	0	1	0	0
SERHL2	253190	broad.mit.edu	37	22	42962318	42962318	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:42962318C>A	ENST00000327678.5	+	9	724	c.622C>A	c.(622-624)Ctg>Atg	p.L208M	SERHL2_ENST00000335879.5_Missense_Mutation_p.L144M|RRP7B_ENST00000357802.2_RNA|SERHL2_ENST00000407614.4_Missense_Mutation_p.L28M|SERHL2_ENST00000340239.4_Intron	NM_014509.3	NP_055324.2	Q9H4I8	SEHL2_HUMAN	serine hydrolase-like 2	208						perinuclear region of cytoplasm|peroxisome	hydrolase activity			breast(1)|endometrium(2)|lung(3)|skin(1)|stomach(1)	8						AGGTCTGGTTCTGAACAGAGA	0.572000													35	47					2.91434e-09	3.01617e-09	1	1	0
SH3KBP1	30011	broad.mit.edu	37	X	19560282	19560282	+	Silent	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:19560282G>T	ENST00000397821.3	-	16	1943	c.1653C>A	c.(1651-1653)ccC>ccA	p.P551P	SH3KBP1_ENST00000541422.1_Silent_p.P290P|SH3KBP1_ENST00000379716.1_Silent_p.P313P|SH3KBP1_ENST00000379698.4_Silent_p.P514P	NM_031892.2	NP_114098.1	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1	551					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(4)	29						TCCCCGGCTTGGGCGGCAGGG	0.637000													9	43					1.12685e-05	1.14274e-05	1	1	0
GREM2	64388	broad.mit.edu	37	1	240656456	240656456	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:240656456G>A	ENST00000318160.4	-	2	586	c.320C>T	c.(319-321)cCg>cTg	p.P107L		NM_022469.3	NP_071914.3	Q9H772	GREM2_HUMAN	gremlin 2, DAN family BMP antagonist	107	CTCK.				BMP signaling pathway	extracellular space	cytokine activity			endometrium(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	10		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			CACGTGCCGCGGGATGTAGAA	0.667000													11	86					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41084104	41084104	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:41084104G>C	ENST00000324545.8	+	40	7494	c.6861G>C	c.(6859-6861)aaG>aaC	p.K2287N	USP9X_ENST00000378308.2_Missense_Mutation_p.K2287N	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						GTTATGTGAAGAAAATCATTG	0.393000													20	54					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71683616	71683616	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:71683616G>A	ENST00000393524.2	-	17	3681	c.2948C>T	c.(2947-2949)cCa>cTa	p.P983L	PHLPP2_ENST00000356272.3_Missense_Mutation_p.P1050L|PHLPP2_ENST00000567016.1_Missense_Mutation_p.P1085L|PHLPP2_ENST00000568954.1_Missense_Mutation_p.P1050L|PHLPP2_ENST00000540628.1_Intron|PHLPP2_ENST00000360429.3_Intron			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	1050	PP2C-like.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						CACAGGACCTGGGAGGGTGAG	0.522000													41	189					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70333675	70333675	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:70333675C>T	ENST00000373644.4	+	2	1789	c.1580C>T	c.(1579-1581)tCa>tTa	p.S527L		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	527					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						TTCCATGCTTCACTGGGTATA	0.493000													17	35					0	0	1	0	0
TBC1D32	221322	broad.mit.edu	37	6	121401953	121401953	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:121401953C>T	ENST00000275159.6	-	33	3860	c.3861G>A	c.(3859-3861)ctG>ctA	p.L1287L	TBC1D32_ENST00000398212.2_Silent_p.L1246L|TBC1D32_ENST00000398197.2_5'UTR					TBC1 domain family, member 32																		GCATGTCTCTCAGCAGCACTG	0.388000													38	55					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52475406	52475406	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:52475406G>A	ENST00000231721.2	-	7	686	c.687C>T	c.(685-687)gcC>gcT	p.A229A		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	229	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity	p.A229A(1)		kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		GGATCCGGGCGGCCATCACAA	0.612000													10	25					0	0	1	0	0
ADAM11	4185	broad.mit.edu	37	17	42853498	42853498	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:42853498G>A	ENST00000200557.6	+	18	1658	c.1489G>A	c.(1489-1491)Gaa>Aaa	p.E497K	ADAM11_ENST00000535346.1_Missense_Mutation_p.E297K	NM_002390.4	NP_002381.2	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11	497	Disintegrin.				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Prostate(33;0.0959)				TCCCTAGTACGAACCACGGGG	0.701000													24	63					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216236649	216236649	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:216236649C>T	ENST00000354785.4	-	40	7066	c.6697G>A	c.(6697-6699)Gat>Aat	p.D2233N	FN1_ENST00000421182.1_Missense_Mutation_p.D1996N|FN1_ENST00000432072.2_Missense_Mutation_p.D2023N|FN1_ENST00000336916.4_Missense_Mutation_p.D2111N|FN1_ENST00000359671.1_Missense_Mutation_p.D2142N|FN1_ENST00000345488.5_Intron|FN1_ENST00000346544.3_Missense_Mutation_p.D2022N|FN1_ENST00000357009.2_Missense_Mutation_p.D2022N|FN1_ENST00000357867.4_Missense_Mutation_p.D1932N|FN1_ENST00000446046.1_Missense_Mutation_p.D2086N|FN1_ENST00000443816.1_Missense_Mutation_p.D2021N|FN1_ENST00000356005.4_Missense_Mutation_p.D2052N|FN1_ENST00000323926.6_Missense_Mutation_p.D2202N			P02751	FINC_HUMAN	fibronectin 1	2142	Fibrin-binding 2.|Fibronectin type-I 10.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTTCTTCATCAGTGCCAACA	0.453000													20	54					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211488	78211488	+	RNA	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:78211488G>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCTGCTCCTGGAGTCTCTGCT	0.587000													40	82					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157528023	157528023	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:157528023C>G	ENST00000346085.5	+	20	5749	c.5748C>G	c.(5746-5748)atC>atG	p.I1916M	ARID1B_ENST00000275248.4_Missense_Mutation_p.I1898M|ARID1B_ENST00000367148.1_Missense_Mutation_p.I1956M|ARID1B_ENST00000350026.5_Missense_Mutation_p.I1903M	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1903					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		ACCGGAACATCAAGCTGCTGG	0.587000													35	62					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37880257	37880257	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:37880257C>G	ENST00000406381.2	+	21	2721	c.2211C>G	c.(2209-2211)atC>atG	p.I737M	ERBB2_ENST00000540147.1_Missense_Mutation_p.I737M|ERBB2_ENST00000269571.5_Missense_Mutation_p.I767M|ERBB2_ENST00000541774.1_Missense_Mutation_p.I752M|ERBB2_ENST00000445658.2_Missense_Mutation_p.I491M|ERBB2_ENST00000584601.1_Missense_Mutation_p.I737M|ERBB2_ENST00000584450.1_Missense_Mutation_p.I767M	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	767	Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.I767M(2)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ACAAAGAAATCTTAGACGTAA	0.542000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			9	22					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76525741	76525741	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:76525741C>T	ENST00000389840.5	-	22	3444	c.3320G>A	c.(3319-3321)aGa>aAa	p.R1107K	DNAH17_ENST00000585328.1_Missense_Mutation_p.R1104K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAAGCCCATTCTGGCGACTTT	0.592000													4	44					0	0	1	0	0
NUP133	55746	broad.mit.edu	37	1	229586337	229586337	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:229586337C>A	ENST00000261396.3	-	23	3206	c.3115G>T	c.(3115-3117)Gaa>Taa	p.E1039*	NUP133_ENST00000537506.1_Nonsense_Mutation_p.E1023*|NUP133_ENST00000485119.1_5'UTR	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	1039					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				CTTCTATTTTCTTCACAGATA	0.299000													19	133					9.7654e-05	9.88318e-05	1	1	0
TSIX	9383	broad.mit.edu	37	X	73042146	73042146	+	RNA	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:73042146G>C	ENST00000604411.1	+	0	30107				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GTAGTGGCCAGAGTGGTAGAA	0.413000													5	19					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74649157	74649157	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:74649157C>T	ENST00000253159.8	+	26	4832	c.4634C>T	c.(4633-4635)tCt>tTt	p.S1545F	ZNF236_ENST00000320610.9_Missense_Mutation_p.S1547F	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1545					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		ACACCGATGTCTCCATCGGCC	0.527000													31	19					0	0	1	0	0
TRAV19	28664	broad.mit.edu	37	14	22475835	22475835	+	RNA	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:22475835C>T	ENST00000390447.3	+	0	85																											AGACGGAGCACGGAACATTTC	0.493000													3	7					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148025826	148025826	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:148025826C>T	ENST00000369219.1	-	1	22	c.6G>A	c.(4-6)ctG>ctA	p.L2L				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	2						cytoplasm				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					GCTCATTCCTCAGCATAGATT	0.537000													60	202					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70361046	70361046	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:70361046G>A	ENST00000305107.6	-	1	580	c.534C>T	c.(532-534)taC>taT	p.Y178Y	UGT2B4_ENST00000512583.1_Silent_p.Y178Y|UGT2B4_ENST00000381096.3_Silent_p.Y42Y|UGT2B4_ENST00000506580.1_Intron	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	178					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						TTTCAATTGCGTAGCCAGGAG	0.453000													8	59					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55512138	55512138	+	Missense_Mutation	SNP	G	G	C	rs144393067		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:55512138G>C	ENST00000543010.1	+	13	3204	c.3061G>C	c.(3061-3063)Gat>Cat	p.D1021H	NLRP2_ENST00000339757.7_Missense_Mutation_p.D999H|NLRP2_ENST00000427260.2_Missense_Mutation_p.D998H|NLRP2_ENST00000538819.1_Missense_Mutation_p.D997H|NLRP2_ENST00000263437.6_Missense_Mutation_p.D1018H|NLRP2_ENST00000537859.1_Missense_Mutation_p.D999H|NLRP2_ENST00000391721.4_Missense_Mutation_p.D997H|NLRP2_ENST00000448584.2_Missense_Mutation_p.D1021H	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	1021					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GTTGAAAATCGATGACTTTAA	0.393000													13	60					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76280745	76280745	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:76280745G>A	ENST00000263187.3	+	5	843	c.739G>A	c.(739-741)Gaa>Aaa	p.E247K		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	247					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						ATACTTCAATGAAACAAAAGG	0.318000								Mismatch excision repair (MMR)					31	57					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21249665	21249665	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:21249665C>G	ENST00000233242.1	-	15	2366	c.2239G>C	c.(2239-2241)Gag>Cag	p.E747Q	APOB_ENST00000399256.4_Missense_Mutation_p.E747Q	NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	747					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CACACCTGCTCATGTTTATCA	0.383000													16	48					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400223	40400223	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:40400223C>G	ENST00000338305.6	-	2	1172	c.630G>C	c.(628-630)caG>caC	p.Q210H		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	210						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGGGCAGCTTCTGCAGCCGAT	0.602000													18	34					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12711208	12711208	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:12711208G>A	ENST00000376221.1	+	2	235	c.235G>A	c.(235-237)Gtg>Atg	p.V79M		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	79						integral to membrane	carboxylesterase activity	p.V79M(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		ACATGATAGCGTGAGAATTAA	0.478000													14	91					0	0	1	0	0
NUSAP1	51203	broad.mit.edu	37	15	41657766	41657766	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:41657766C>G	ENST00000260359.6	+	7	1046	c.782C>G	c.(781-783)tCt>tGt	p.S261C	NUSAP1_ENST00000558123.1_3'UTR|NUSAP1_ENST00000450592.2_Missense_Mutation_p.S252C|NUSAP1_ENST00000560747.1_Missense_Mutation_p.S274C|NUSAP1_ENST00000560177.1_Missense_Mutation_p.S275C|NUSAP1_ENST00000450318.1_Missense_Mutation_p.S276C|NUSAP1_ENST00000414849.2_Missense_Mutation_p.S275C|NUSAP1_ENST00000559596.1_Missense_Mutation_p.S276C	NM_001243142.1|NM_001243143.1|NM_016359.4|NM_018454.7	NP_001230071.1|NP_001230072.1|NP_057443.2|NP_060924.4	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	276	Interaction with microtubules (By similarity).				cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)|ovary(1)|prostate(2)|urinary_tract(2)	13		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		TCTGCTATCTCTGCAGCTAAA	0.443000													6	7					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475034	140475034	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:140475034G>C	ENST00000194155.4	+	1	808	c.660G>C	c.(658-660)ggG>ggC	p.G220G		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		220	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAGATGGCGGGAGTCCACCCA	0.557000													6	37					0	0	1	0	0
CARF	79800	broad.mit.edu	37	2	203817303	203817303	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:203817303G>A	ENST00000402905.3	+	5	649	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	CARF_ENST00000320443.8_Missense_Mutation_p.E110K|CARF_ENST00000444724.1_Missense_Mutation_p.E110K|CARF_ENST00000428585.1_Missense_Mutation_p.E34K|CARF_ENST00000471271.1_3'UTR|CARF_ENST00000434998.1_Missense_Mutation_p.E8K|CARF_ENST00000438828.2_Missense_Mutation_p.E110K|CARF_ENST00000545253.1_Missense_Mutation_p.E22K|WDR12_ENST00000477723.1_Intron|CARF_ENST00000456821.2_Missense_Mutation_p.E98K|CARF_ENST00000414439.1_Missense_Mutation_p.E8K|CARF_ENST00000545262.1_Missense_Mutation_p.E34K	NM_001104586.1|NM_001282910.1|NM_001282911.1|NM_001282912.1	NP_001098056.1|NP_001269839.1|NP_001269840.1|NP_001269841.1			calcium responsive transcription factor																		CAGCCCAACAGAAAATGGACA	0.373000													25	76					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86125001	86125001	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:86125001C>G	ENST00000394518.2	+	7	3797	c.3702C>G	c.(3700-3702)gtC>gtG	p.V1234V	AKAP13_ENST00000361243.2_Silent_p.V1234V	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1234					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						CTTGCATGGTCTCTGCCCAGG	0.602000													10	20					0	0	1	0	0
TSC22D3	1831	broad.mit.edu	37	X	107018395	107018395	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:107018395G>C	ENST00000372383.4	-	1	622	c.255C>G	c.(253-255)atC>atG	p.I85M	TSC22D3_ENST00000514426.1_Missense_Mutation_p.I17M|TSC22D3_ENST00000372384.2_Missense_Mutation_p.I85M|TSC22D3_ENST00000506081.1_Missense_Mutation_p.I85M|TSC22D3_ENST00000315660.4_Missense_Mutation_p.I85M	NM_198057.2	NP_932174.1	Q99576	T22D3_HUMAN	TSC22 domain family, member 3	0	Leucine-zipper.						sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)|lung(3)	6						TGCCCTCGTTGATCAGGTAGC	0.577000													39	69					0	0	1	0	0
RELB	5971	broad.mit.edu	37	19	45540802	45540802	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:45540802C>G	ENST00000221452.8	+	12	1644	c.1494C>G	c.(1492-1494)ctC>ctG	p.L498L	RELB_ENST00000540120.1_Silent_p.L498L|RELB_ENST00000505236.1_Silent_p.L495L	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	498						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		CCCCCACACTCTTCACCATGC	0.701000													23	18					0	0	1	0	0
GTDC1	79712	broad.mit.edu	37	2	144899508	144899508	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:144899508G>C	ENST00000392869.2	-	5	614	c.462C>G	c.(460-462)agC>agG	p.S154R	GTDC1_ENST00000409298.1_Missense_Mutation_p.S154R|GTDC1_ENST00000344850.4_Missense_Mutation_p.S154R|GTDC1_ENST00000409214.1_Missense_Mutation_p.S154R|GTDC1_ENST00000392867.3_Missense_Mutation_p.S154R|GTDC1_ENST00000463875.2_Missense_Mutation_p.S25R|GTDC1_ENST00000542155.1_Missense_Mutation_p.S154R|GTDC1_ENST00000241391.5_Missense_Mutation_p.S154R	NM_001284234.1	NP_001271163.1	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1						biosynthetic process		transferase activity, transferring glycosyl groups			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(17)|ovary(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.0914)		GTCTGATGATGCTTTCCAGAT	0.383000													21	67					0	0	1	0	0
SPATA6	54558	broad.mit.edu	37	1	48865165	48865165	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:48865165G>A	ENST00000371847.3	-	7	802	c.638C>T	c.(637-639)tCa>tTa	p.S213L	SPATA6_ENST00000371843.3_Missense_Mutation_p.S213L|SPATA6_ENST00000463938.1_5'UTR|SPATA6_ENST00000396199.3_Missense_Mutation_p.S141L	NM_019073.2	NP_061946.1	Q9NWH7	SPAT6_HUMAN	spermatogenesis associated 6	213					cell differentiation|multicellular organismal development|spermatogenesis	extracellular region				breast(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	21						GTGTGATTTTGAAGAAATTGT	0.413000													55	135					0	0	1	0	0
CCT7	10574	broad.mit.edu	37	2	73474901	73474901	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:73474901G>A	ENST00000539919.1	+	8	869	c.498G>A	c.(496-498)ctG>ctA	p.L166L	CCT7_ENST00000537131.1_Silent_p.L110L|CCT7_ENST00000258091.5_Silent_p.L210L|CCT7_ENST00000540468.1_Silent_p.L123L|CCT7_ENST00000538797.1_Silent_p.L82L|CCT7_ENST00000473786.1_3'UTR|CCT7_ENST00000398422.2_Silent_p.L6L	NM_001166285.1	NP_001159757.1	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 (eta)	210					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding			breast(1)|cervix(1)|endometrium(1)|lung(3)|stomach(1)	7						ATTCTCAGCTGGTAGCTGGTG	0.388000													12	17					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183695342	183695342	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:183695342G>C	ENST00000334444.6	-	10	1607	c.1367C>G	c.(1366-1368)tCc>tGc	p.S456C	ABCC5_ENST00000492216.1_5'UTR|ABCC5_ENST00000265586.6_Missense_Mutation_p.S456C	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	456	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TTCTGAGAGGGACTTTACTGA	0.488000													9	44					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3112337	3112337	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:3112337G>T	ENST00000356443.4	-	22	3710	c.3377C>A	c.(3376-3378)cCa>cAa	p.P1126Q	MYOM1_ENST00000400569.3_Missense_Mutation_p.P1126Q|MYOM1_ENST00000261606.7_Missense_Mutation_p.P1030Q	NM_003803.3|NM_019856.1	NP_003794.3|NP_062830.1	P52179	MYOM1_HUMAN	myomesin 1	1126	Fibronectin type-III 5.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AAGGTCAGATGGCTTCCCAAC	0.517000													10	26					9.70103e-10	1.00607e-09	1	1	0
SCNN1A	6337	broad.mit.edu	37	12	6457896	6457896	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:6457896G>A	ENST00000358945.3	-	12	2132	c.1692C>T	c.(1690-1692)gtC>gtT	p.V564V	SCNN1A_ENST00000228916.2_Silent_p.V542V|SCNN1A_ENST00000360168.3_Silent_p.V601V|SCNN1A_ENST00000540037.1_Silent_p.V242V|SCNN1A_ENST00000396966.2_3'UTR|SCNN1A_ENST00000543768.1_Silent_p.V565V			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	542					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	GACCTACCGTGACAGAGGGAG	0.532000													23	40					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61036467	61036467	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:61036467C>G	ENST00000335613.5	-	15	2195	c.1809G>C	c.(1807-1809)aaG>aaC	p.K603N	VWCE_ENST00000535710.1_Missense_Mutation_p.K68N	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	603	VWFC 4.					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						AGTCTGTCCTCTTGCAGCTCA	0.632000													20	18					0	0	1	0	0
CD300LD	100131439	broad.mit.edu	37	17	72584701	72584701	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:72584701C>T	ENST00000375352.1	-	2	408	c.328G>A	c.(328-330)Gag>Aag	p.E110K	C17orf77_ENST00000392620.1_Intron	NM_001115152.1	NP_001108624.1	Q6UXZ3	CLM4_HUMAN	CD300 molecule-like family member d	110	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			large_intestine(1)|lung(2)|prostate(1)|stomach(1)	5						CCAGGTCTCTCAGTCCCACAC	0.468000													28	61					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28916510	28916510	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:28916510C>G	ENST00000257192.4	+	9	1411	c.1199C>G	c.(1198-1200)tCa>tGa	p.S400*		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	400	Cadherin 4.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AATATGGGATCAAATGATAAA	0.388000													25	51					0	0	1	0	0
DISC1	27185	broad.mit.edu	37	1	232144764	232144764	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:232144764C>T	ENST00000439617.2	+	11	2329	c.2276C>T	c.(2275-2277)tCt>tTt	p.S759F	DISC1_ENST00000537876.1_3'UTR|DISC1_ENST00000427560.1_3'UTR|DISC1_ENST00000535983.1_3'UTR|DISC1_ENST00000366637.3_Intron	NM_001164537.1|NM_001164540.1|NM_018662.2	NP_001158009.1|NP_001158012.1|NP_061132.2	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1	759	Interaction with ATF4 and ATF5.|Interaction with PAFAH1B1.|Necessary and sufficient for interaction with PCNT and localization at the centrosome.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			breast(1)|cervix(1)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(173;0.0208)|Prostate(94;0.0975)				CTCATCCCCTCTCTGCACTGT	0.537000													4	54					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103124666	103124666	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:103124666C>G	ENST00000295269.4	+	5	1784	c.1327C>G	c.(1327-1329)Ctg>Gtg	p.L443V		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	443					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						TTTGCTTCCTCTGTCTCTTTT	0.378000													10	34					0	0	1	0	0
NOVA2	4858	broad.mit.edu	37	19	46443426	46443426	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:46443426C>T	ENST00000263257.5	-	4	1368	c.1174G>A	c.(1174-1176)Ggg>Agg	p.G392R		NM_002516.2	NP_002507.1	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	392	Ala-rich.|Gly-rich.					nucleus	RNA binding			endometrium(3)|large_intestine(5)|lung(13)	21		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		AGGAAgcccccggccgccccg	0.776000													19	25					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115962858	115962858	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:115962858G>A	ENST00000251864.2	+	7	877	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	TDRD1_ENST00000369280.1_Missense_Mutation_p.E242K|TDRD1_ENST00000369281.2_Missense_Mutation_p.E242K|TDRD1_ENST00000422662.1_5'UTR|TDRD1_ENST00000369282.1_Missense_Mutation_p.E242K	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	242					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		AGTTACTAAGGAAATAGCCAT	0.363000													16	31					0	0	1	0	0
SESTD1	91404	broad.mit.edu	37	2	179989213	179989213	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:179989213G>C	ENST00000428443.3	-	11	1361	c.1045C>G	c.(1045-1047)Ctt>Gtt	p.L349V		NM_178123.4	NP_835224.3	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	349					regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(3)	30			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			AGTTCCACAAGATCTTCCTCA	0.408000													18	35					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59210703	59210703	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:59210703C>G	ENST00000302030.2	+	1	87	c.62C>G	c.(61-63)aCa>aGa	p.T21R		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	21					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						CTGGGATTCACAGACCATCCA	0.532000													20	51					0	0	1	0	0
PCMT1	5110	broad.mit.edu	37	6	150094290	150094290	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:150094290C>T	ENST00000464889.1	+	3	635	c.351C>T	c.(349-351)atC>atT	p.I117I	PCMT1_ENST00000367384.2_Silent_p.I117I|PCMT1_ENST00000544496.1_Silent_p.I24I|PCMT1_ENST00000367380.5_Silent_p.I59I|PCMT1_ENST00000367378.1_Silent_p.I117I					protein-L-isoaspartate (D-aspartate) O-methyltransferase											kidney(1)|large_intestine(2)|lung(4)|ovary(1)	8		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.221)	OV - Ovarian serous cystadenocarcinoma(155;5.63e-13)|GBM - Glioblastoma multiforme(68;0.207)		AAGCAACAATCAGTGCTCCAC	0.308000													12	41					0	0	1	0	0
TINAGL1	64129	broad.mit.edu	37	1	32050798	32050798	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:32050798G>A	ENST00000271064.7	+	8	980	c.904G>A	c.(904-906)Gag>Aag	p.E302K	TINAGL1_ENST00000481165.1_3'UTR|TINAGL1_ENST00000457433.2_Missense_Mutation_p.E271K	NM_001204415.1|NM_022164.2	NP_001191344.1|NP_071447.1	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	302					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity			breast(2)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		TGAACGAGACGAGGCTGGCCC	0.612000													14	136					0	0	1	0	0
PNMA2	10687	broad.mit.edu	37	8	26365224	26365224	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:26365224C>T	ENST00000522362.2	-	3	1942	c.1048G>A	c.(1048-1050)Gag>Aag	p.E350K		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	350					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		TCTCGTTCCTCTGGCTCTTCG	0.537000													25	55					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61438989	61438989	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:61438989C>G	ENST00000398571.2	-	69	8834	c.8758G>C	c.(8758-8760)Gat>Cat	p.D2920H	USP34_ENST00000472689.1_5'UTR	NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	2920					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TGTTTAATATCTTCTAATTCT	0.363000													16	31					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50125513	50125513	+	RNA	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:50125513C>T	ENST00000376025.2	-	0	2697							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					CCTGGGTGTTCATCTCTTCTG	0.393000													22	28					0	0	1	0	0
ZNF432	9668	broad.mit.edu	37	19	52537404	52537404	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:52537404C>G	ENST00000594154.1	-	5	1740	c.1528G>C	c.(1528-1530)Gag>Cag	p.E510Q	ZNF432_ENST00000221315.5_Missense_Mutation_p.E510Q			O94892	ZN432_HUMAN	zinc finger protein 432	510					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	29		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TACGGTTTCTCTCCAGTATGA	0.428000													11	80					0	0	1	0	0
COASY	80347	broad.mit.edu	37	17	40716490	40716490	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:40716490G>C	ENST00000393818.2	+	3	1398	c.942G>C	c.(940-942)caG>caC	p.Q314H	COASY_ENST00000449624.1_Missense_Mutation_p.Q19H|COASY_ENST00000590958.1_Missense_Mutation_p.Q343H|COASY_ENST00000420359.1_Missense_Mutation_p.Q314H|COASY_ENST00000421097.2_Missense_Mutation_p.Q314H	NM_025233.6	NP_079509.5	Q13057	COASY_HUMAN	CoA synthase	314	Phosphopantetheine adenylyltransferase.				coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)	21		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		CTTTGTACCAGATCCAGCTGC	0.547000													20	35					0	0	1	0	0
IGHV3-72	28410	broad.mit.edu	37	14	107198952	107198952	+	RNA	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:107198952C>T	ENST00000433072.2	-	0	416																											TAATACACGGCCGTGTCCTCG	0.562000													36	141					0	0	1	0	0
KATNB1	10300	broad.mit.edu	37	16	57789974	57789974	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:57789974G>A	ENST00000379661.3	+	18	2106	c.1714G>A	c.(1714-1716)Gag>Aag	p.E572K		NM_005886.2	NP_005877.2	Q9BVA0	KTNB1_HUMAN	katanin p80 (WD repeat containing) subunit B 1	572	Interaction with KATNA1 and NDEL1 (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_neural(199;0.223)				GAGCAAGTATGAGAGGTGCGT	0.602000													16	19					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2939301	2939301	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:2939301C>G	ENST00000378404.2	+	1	1256	c.1051C>G	c.(1051-1053)Ctg>Gtg	p.L351V		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	351						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		CGTCACCTCTCTGAGTAGCTT	0.602000													26	148					0	0	1	0	0
CALR	811	broad.mit.edu	37	19	13051060	13051060	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:13051060G>A	ENST00000316448.5	+	5	569	c.496G>A	c.(496-498)Gat>Aat	p.D166N		NM_004343.3	NP_004334.1	P27797	CALR_HUMAN	calreticulin	166	N-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(1)	10					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTTCAGGATGATGAGTTTAC	0.557000													50	30					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58384348	58384348	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:58384348C>G	ENST00000435989.2	-	3	2644	c.2410G>C	c.(2410-2412)Gaa>Caa	p.E804Q	ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597832.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	804					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						TTTCCACATTCACTGCACTCA	0.393000													16	49					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39008933	39008933	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:39008933G>A	ENST00000379907.4	+	6	518	c.391G>A	c.(391-393)Gag>Aag	p.E131K	ADAM32_ENST00000437682.2_Missense_Mutation_p.E138K|ADAM32_ENST00000519315.1_Missense_Mutation_p.E131K	NM_145004.5	NP_659441	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	131					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TTATGGAATTGAGCCTCTGGA	0.289000													5	45					0	0	1	0	0
SURF2	6835	broad.mit.edu	37	9	136227265	136227265	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:136227265G>C	ENST00000371964.4	+	5	683	c.642G>C	c.(640-642)agG>agC	p.R214S		NM_017503.3	NP_059973.4	Q15527	SURF2_HUMAN	surfeit 2	214							protein binding			breast(1)|large_intestine(1)|lung(4)	6				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		ATGAGAGCAGGAGAGAGACGA	0.552000													3	7					0	0	1	0	0
DDX42	11325	broad.mit.edu	37	17	61886279	61886279	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:61886279G>C	ENST00000578681.1	+	11	1724	c.1123G>C	c.(1123-1125)Gag>Cag	p.E375Q	DDX42_ENST00000583590.1_Missense_Mutation_p.E375Q|DDX42_ENST00000389924.2_Missense_Mutation_p.E375Q|DDX42_ENST00000359353.5_Missense_Mutation_p.E256Q|DDX42_ENST00000457800.2_Missense_Mutation_p.E375Q	NM_007372.2	NP_031398.2	Q86XP3	DDX42_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 42	375	Helicase ATP-binding.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)	46						GGCCCTTCAGGAGGGGGCAGA	0.483000													26	50					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71209258	71209258	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:71209258C>A	ENST00000554752.2	-	6	1376	c.1377G>T	c.(1375-1377)aaG>aaT	p.K459N	MAP3K9_ENST00000554146.1_Missense_Mutation_p.K196N|MAP3K9_ENST00000555993.2_Missense_Mutation_p.K459N|MAP3K9_ENST00000381250.4_Missense_Mutation_p.K459N|MAP3K9_ENST00000553414.1_Missense_Mutation_p.K153N	NM_001284230.1	NP_001271159.1	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	459					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CCTCCTGGTTCTTCTGCTGCA	0.612000													13	20					6.31663e-08	6.49066e-08	1	1	0
HIST1H2AJ	8331	broad.mit.edu	37	6	27782458	27782458	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:27782458G>A	ENST00000333151.3	-	1	149	c.61C>T	c.(61-63)Cgg>Tgg	p.R21W		NM_021066.2	NP_066544.1	Q99878	H2A1J_HUMAN	histone cluster 1, H2aj	21					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	11						AGCCCGGCCCGAGAAGAGCGG	0.612000													12	49					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140174823	140174823	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:140174823C>T	ENST00000526136.1	+	1	274	c.274C>T	c.(274-276)Cgg>Tgg	p.R92W	PCDHA2_ENST00000378132.1_Missense_Mutation_p.R92W|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Missense_Mutation_p.R92W	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGATCGACCGGGAGGAGCT	0.587000													99	82					0	0	1	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617807	111617807	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:111617807C>T	ENST00000374667.3	-	1	1432	c.404G>A	c.(403-405)cGc>cAc	p.R135H		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	135						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						CATGGCGGTGCGGAAGATGTA	0.627000													26	14					0	0	1	0	0
ZNF609	23060	broad.mit.edu	37	15	64915042	64915042	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:64915042C>T	ENST00000326648.3	+	2	892	c.764C>T	c.(763-765)tCc>tTc	p.S255F		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	255						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCCCCTGTTTCCACACCAGCA	0.463000													11	68					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187197423	187197423	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:187197423G>A	ENST00000264692.4	+	7	811	c.478G>A	c.(478-480)Gac>Aac	p.D160N	F11_ENST00000403665.2_Missense_Mutation_p.D212N			P03951	FA11_HUMAN	coagulation factor XI	212	Apple 2.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	GGTGTTTGCAGACAGCAACAT	0.478000													8	63					0	0	1	0	0
CAMK1	8536	broad.mit.edu	37	3	9799522	9799522	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:9799522G>C	ENST00000256460.3	-	11	1098	c.921C>G	c.(919-921)ttC>ttG	p.F307L	OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000302036.7_Intron|OGG1_ENST00000449570.2_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	307	Autoinhibitory domain (By similarity).|Calmodulin-binding (By similarity).				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		CCGTGGCATTGAAGGCTTGCT	0.597000													23	32					0	0	1	0	0
ZNF439	90594	broad.mit.edu	37	19	11976998	11976998	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:11976998C>G	ENST00000304030.2	+	1	227	c.27C>G	c.(25-27)ctC>ctG	p.L9L	ZNF439_ENST00000592534.1_Intron|ZNF439_ENST00000455282.1_Intron	NM_152262.2	NP_689475.1	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(7)|pancreas(1)|skin(2)	27						CCATCCTCCTCTACACATGTG	0.498000													115	64					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102088980	102088980	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:102088980C>G	ENST00000318222.3	-	2	719	c.337G>C	c.(337-339)Gac>Cac	p.D113H	PKD2L1_ENST00000338519.3_Missense_Mutation_p.D113H|PKD2L1_ENST00000353274.3_Missense_Mutation_p.D113H	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	113					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		AGACAGATGTCCACCAGGAAC	0.443000													9	48					0	0	1	0	0
NR1H3	10062	broad.mit.edu	37	11	47289495	47289495	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:47289495C>G	ENST00000467728.1	+	7	2258	c.1020C>G	c.(1018-1020)ttC>ttG	p.F340L	NR1H3_ENST00000407404.1_Missense_Mutation_p.F280L|NR1H3_ENST00000529540.1_3'UTR|NR1H3_ENST00000405853.3_Missense_Mutation_p.F280L|NR1H3_ENST00000405576.1_Missense_Mutation_p.F235L|NR1H3_ENST00000395397.3_Missense_Mutation_p.F295L|NR1H3_ENST00000441012.2_Missense_Mutation_p.F340L|NR1H3_ENST00000481889.2_Missense_Mutation_p.F359L|NR1H3_ENST00000527949.1_Missense_Mutation_p.F189L			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	340	Ligand-binding (Potential).				apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						ACCCCATCTTCGAGTTCTCCA	0.532000													23	27					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192711645	192711645	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:192711645C>G	ENST00000304141.4	-	1	336	c.7G>C	c.(7-9)Gag>Cag	p.E3Q	AC098617.1_ENST00000424116.2_RNA	NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	3						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GCAGCGTCCTCTCCCATGGCT	0.622000													15	50					0	0	1	0	0
RRP1B	23076	broad.mit.edu	37	21	45113165	45113165	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr21:45113165G>C	ENST00000340648.4	+	16	2295	c.2178G>C	c.(2176-2178)ctG>ctC	p.L726L		NM_015056.2	NP_055871.1	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1B	726					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(1)	21				STAD - Stomach adenocarcinoma(101;0.178)		ACGGGGTGCTGAAGACCCCCA	0.592000													5	17					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39230279	39230279	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:39230279C>G	ENST00000340369.3	-	2	886	c.658G>C	c.(658-660)Gag>Cag	p.E220Q	XIRP1_ENST00000396251.1_Missense_Mutation_p.E220Q|XIRP1_ENST00000421646.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	220							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TCCTGGATCTCTGAGCGCAGT	0.612000													23	56					0	0	1	0	0
MMGT1	93380	broad.mit.edu	37	X	135047188	135047188	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:135047188G>A	ENST00000305963.2	-	4	778	c.391C>T	c.(391-393)Cgt>Tgt	p.R131C	MMGT1_ENST00000433339.2_Missense_Mutation_p.R196C	NM_173470.1	NP_775741.1	Q8N4V1	MMGT1_HUMAN	membrane magnesium transporter 1	131						early endosome membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	magnesium ion transmembrane transporter activity			cervix(1)|endometrium(1)|kidney(1)	3						AAATCTTAACGACGCAGTGAT	0.393000													5	195					0	0	1	0	0
DOK1	1796	broad.mit.edu	37	2	74783531	74783531	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:74783531G>T	ENST00000233668.5	+	5	1405	c.736G>T	c.(736-738)Gag>Tag	p.E246*	DOK1_ENST00000340004.6_3'UTR|DOK1_ENST00000409429.1_Nonsense_Mutation_p.E107*|DOK1_ENST00000480318.1_3'UTR	NM_001381.3	NP_001372.1	Q99704	DOK1_HUMAN	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	246	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding			endometrium(3)|large_intestine(2)|liver(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						CCAGGCAGTTGAGACTGCCAT	0.607000													5	50					0.014758	0.0148464	1	1	0
ZNF572	137209	broad.mit.edu	37	8	125990084	125990084	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:125990084C>G	ENST00000319286.5	+	3	1728	c.1574C>G	c.(1573-1575)tCa>tGa	p.S525*		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	525					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TTTTCCGTCTCAAATTCATCT	0.423000										HNSCC(60;0.17)			7	43					0	0	1	0	0
AMFR	267	broad.mit.edu	37	16	56423280	56423280	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:56423280G>C	ENST00000290649.5	-	9	1303	c.1093C>G	c.(1093-1095)Ctt>Gtt	p.L365V		NM_001144.5	NP_001135.3	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor, E3 ubiquitin protein ligase	365					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17						CAGGAACGAAGACAGGAGCTA	0.423000													30	31					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62985184	62985184	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:62985184C>G	ENST00000403374.2	-	4	335	c.32G>C	c.(31-33)aGa>aCa	p.R11T	SLC22A25_ENST00000306494.6_Missense_Mutation_p.R177T|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron			Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	177					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						GTAAGACCATCTGAGCACGAA	0.507000													7	28					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29632660	29632660	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:29632660G>A	ENST00000278882.3	+	8	855	c.475G>A	c.(475-477)Gag>Aag	p.E159K	FRG1B_ENST00000358464.4_Missense_Mutation_p.E159K																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AAGTAAAGAAGAGAGTAAAAT	0.318000													8	632					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48612912	48612912	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:48612912G>A	ENST00000328333.8	-	73	6147	c.6040C>T	c.(6040-6042)Cag>Tag	p.Q2014*	COL7A1_ENST00000454817.1_Nonsense_Mutation_p.Q1982*	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2014	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGTGGCCCCTGAGGGCCAGGG	0.692000													9	14					0	0	1	0	0
RASL10B	91608	broad.mit.edu	37	17	34068249	34068249	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:34068249C>A	ENST00000268864.3	+	4	914	c.537C>A	c.(535-537)tgC>tgA	p.C179*		NM_033315.3	NP_201572.1	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B	179	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCGTCGGCTGCGCCCGTTGCA	0.667000													6	15					0.0215528	0.0216603	1	1	0
NOA1	84273	broad.mit.edu	37	4	57840116	57840116	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:57840116C>G	ENST00000264230.4	-	2	2454	c.1217G>C	c.(1216-1218)aGa>aCa	p.R406T		NM_032313.2	NP_115689.1	Q8NC60	CD014_HUMAN	nitric oxide associated 1	406							GTP binding										TTTTTTAAGTCTTTGATGCCT	0.338000													16	37					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9224898	9224898	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:9224898C>T	ENST00000382496.5	-	8	1199	c.534G>A	c.(532-534)gaG>gaA	p.E178E		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	178	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						CAGCATAGAGCTCCCCACCAG	0.557000													18	17					0	0	1	0	0
HIST1H4E	8367	broad.mit.edu	37	6	26204900	26204900	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:26204900G>A	ENST00000360441.4	+	1	43	c.28G>A	c.(28-30)Gga>Aga	p.G10R		NM_003545.3	NP_003536.1	P62805	H4_HUMAN	histone cluster 1, H4e	10					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	18		all_hematologic(11;0.196)				AGGCGGAAAGGGACTGGGTAA	0.547000													27	43					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4945331	4945331	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:4945331G>C	ENST00000345988.2	-	11	1262	c.1173C>G	c.(1171-1173)ctC>ctG	p.L391L	PPL_ENST00000590782.2_Silent_p.L389L	NM_002705.4	NP_002696	O60437	PEPL_HUMAN	periplakin	391					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GGCGGTACTTGAGGGGCACCA	0.642000													10	50					0	0	1	0	0
KLF10	7071	broad.mit.edu	37	8	103663469	103663469	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:103663469G>C	ENST00000395884.3	-	3	1960	c.1058C>G	c.(1057-1059)tCa>tGa	p.S353*	KLF10_ENST00000285407.6_Nonsense_Mutation_p.S364*	NM_001032282.2	NP_001027453.1	Q13118	KLF10_HUMAN	Kruppel-like factor 10	364					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(3)	18	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			CCTTATCCTTGATGAATCAAT	0.537000													26	82					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77644831	77644831	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:77644831C>G	ENST00000407578.2	-	69	12105	c.11839G>C	c.(11839-11841)Gac>Cac	p.D3947H	MYCBP2_ENST00000357337.6_Missense_Mutation_p.D3909H|MYCBP2_ENST00000544440.2_Missense_Mutation_p.D3909H	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3909					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TCTTTCAGGTCAGCATCTGAT	0.299000													44	80					0	0	1	0	0
ATN1	1822	broad.mit.edu	37	12	7047656	7047656	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:7047656G>T	ENST00000356654.4	+	7	2767	c.2530G>T	c.(2530-2532)Gag>Tag	p.E844*	ATN1_ENST00000396684.2_Nonsense_Mutation_p.E844*	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	844					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						GTTGGCTCAGGAGGGCCGTGC	0.587000											OREG0021641	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	22					5.50884e-06	5.6091e-06	1	1	0
HHLA2	11148	broad.mit.edu	37	3	108076972	108076972	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:108076972G>C	ENST00000357759.5	+	6	1381	c.967G>C	c.(967-969)Gaa>Caa	p.E323Q	HHLA2_ENST00000467562.1_Missense_Mutation_p.E259Q|HHLA2_ENST00000467761.1_Missense_Mutation_p.E323Q|HHLA2_ENST00000491820.1_Missense_Mutation_p.E323Q|HHLA2_ENST00000489514.2_Missense_Mutation_p.E323Q	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	323	Ig-like V-type 2.					integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						TTCTTCGGATGAATATACTTT	0.363000													14	34					0	0	1	0	0
NME7	29922	broad.mit.edu	37	1	169206874	169206874	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:169206874G>C	ENST00000367811.3	-	8	1062	c.806C>G	c.(805-807)tCa>tGa	p.S269*	NME7_ENST00000472647.1_Nonsense_Mutation_p.S233*	NM_013330.3	NP_037462.1	Q9Y5B8	NDK7_HUMAN	NME/NM23 family member 7	269					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(8)|skin(1)	16	all_hematologic(923;0.208)					CTGCATAGCTGAGATTTCAAA	0.328000													30	94					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43748764	43748764	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:43748764C>G	ENST00000263801.3	-	12	2279	c.2027G>C	c.(2026-2028)gGa>gCa	p.G676A	TP53BP1_ENST00000382044.4_Missense_Mutation_p.G681A|TP53BP1_ENST00000450115.2_Missense_Mutation_p.G681A|TP53BP1_ENST00000382039.3_Missense_Mutation_p.G681A	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	676					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GAGTTCCTCTCCTTGACTTTC	0.453000								Other conserved DNA damage response genes					20	64					0	0	1	0	0
BGLAP	632	broad.mit.edu	37	1	156212025	156212025	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:156212025G>A	ENST00000368272.4	+	1	273	c.3G>A	c.(1-3)atG>atA	p.M1I	PMF1_ENST00000567140.1_Intron|PMF1-BGLAP_ENST00000368276.4_Intron|PMF1-BGLAP_ENST00000320139.5_Intron|PMF1-BGLAP_ENST00000490491.1_Intron|PMF1_ENST00000565805.1_Intron	NM_199173.4	NP_954642.1	P02818	OSTCN_HUMAN	bone gamma-carboxyglutamate (gla) protein	1					bone mineralization|cell adhesion|odontogenesis|regulation of bone mineralization|regulation of bone resorption|regulation of osteoclast differentiation		calcium ion binding|hydroxyapatite binding|structural constituent of bone			large_intestine(3)|lung(1)|urinary_tract(1)	5	Hepatocellular(266;0.158)				Phytonadione(DB01022)	GAGACACCATGAGAGCCCTCA	0.667000													11	15					0	0	1	0	0
HSP90B1	7184	broad.mit.edu	37	12	104327748	104327748	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:104327748G>C	ENST00000299767.5	+	5	608	c.426G>C	c.(424-426)aaG>aaC	p.K142N		NM_003299.2	NP_003290.1	P14625	ENPL_HUMAN	heat shock protein 90kDa beta (Grp94), member 1	142					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(4)	29					Rifabutin(DB00615)	ATAAGGAGAAGAACCTGCTGC	0.398000													14	58					0	0	1	0	0
IGF2BP2	10644	broad.mit.edu	37	3	185375096	185375096	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:185375096C>T	ENST00000382199.2	-	12	1459	c.1364G>A	c.(1363-1365)aGa>aAa	p.R455K	IGF2BP2_ENST00000346192.3_Missense_Mutation_p.R412K|IGF2BP2_ENST00000421047.2_Missense_Mutation_p.R398K|IGF2BP2_ENST00000457616.2_Missense_Mutation_p.R461K|IGF2BP2_ENST00000494906.1_5'UTR	NM_006548.4	NP_006539.3	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding protein 2	455	KH 3.				anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	20	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TCCGGCGAATCTCGCCAGCTG	0.592000													11	26					0	0	1	0	0
AATK	9625	broad.mit.edu	37	17	79094976	79094976	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:79094976G>A	ENST00000326724.4	-	11	2784	c.2760C>T	c.(2758-2760)ttC>ttT	p.F920F	AATK_ENST00000417379.1_Silent_p.F817F	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	920						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CCGACGGGCTGAAGACCTCAT	0.637000													4	12					0	0	1	0	0
MAPRE1	22919	broad.mit.edu	37	20	31427559	31427559	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:31427559C>G	ENST00000375571.5	+	5	633	c.494C>G	c.(493-495)tCa>tGa	p.S165*		NM_012325.2	NP_036457.1	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family, member 1	165	Interaction with MTUS2/TIP150.				cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding	p.S165*(1)		endometrium(2)|large_intestine(1)|lung(3)|prostate(2)	8						AGGCCCATCTCAACACAGAGA	0.527000													8	382					0	0	1	0	0
LCLAT1	253558	broad.mit.edu	37	2	30790940	30790940	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:30790940C>G	ENST00000309052.4	+	6	849	c.640C>G	c.(640-642)Cga>Gga	p.R214G	LCLAT1_ENST00000319406.4_Missense_Mutation_p.R214G|LCLAT1_ENST00000359433.1_Missense_Mutation_p.R214G|LCLAT1_ENST00000379509.3_Missense_Mutation_p.R176G|LCLAT1_ENST00000540623.1_Missense_Mutation_p.R176G|LCLAT1_ENST00000491680.2_3'UTR	NM_182551.3	NP_872357.2	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1	214					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)	19						CAGCAAGTCTCGAAGTAATGC	0.313000													15	59					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31777967	31777967	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:31777967C>G	ENST00000375654.4	-	2	1972	c.1783G>C	c.(1783-1785)Gat>Cat	p.D595H	HSPA1L_ENST00000417199.3_Missense_Mutation_p.D595H	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	595					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						CTCTTATGATCAAACTCATCT	0.448000													37	82					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9316282	9316282	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:9316282G>C	ENST00000261336.2	-	21	2746	c.2718C>G	c.(2716-2718)atC>atG	p.I906M	PZP_ENST00000539983.1_5'UTR|PZP_ENST00000381997.2_Intron	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						ACAGGGTTTTGATGACTGTGT	0.433000													18	35					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201618437	201618437	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:201618437C>T	ENST00000367296.4	+	1	1061	c.641C>T	c.(640-642)tCt>tTt	p.S214F	NAV1_ENST00000367302.1_Missense_Mutation_p.S227F|NAV1_ENST00000295624.6_Missense_Mutation_p.S214F|NAV1_ENST00000367297.4_Missense_Mutation_p.S214F|NAV1_ENST00000367300.3_Missense_Mutation_p.S214F	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	214					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						CAAAAGAGCTCTGGGCCTGTC	0.657000													6	14					0	0	1	0	0
ST8SIA1	6489	broad.mit.edu	37	12	22487047	22487047	+	Translation_Start_Site	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:22487047G>T	ENST00000539510.1	-	0	84				ST8SIA1_ENST00000536558.1_Intron|ST8SIA1_ENST00000381424.3_Silent_p.L40L|ST8SIA1_ENST00000396037.4_Silent_p.L40L|ST8SIA1_ENST00000404299.3_Silent_p.L40L			Q92185	SIA8A_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1						glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25						AGAGCCAACAGAGGACCACGA	0.652000													47	63					8.04919e-23	8.58637e-23	1	1	0
RSRC1	51319	broad.mit.edu	37	3	157920947	157920947	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:157920947G>C	ENST00000295930.3	+	4	569	c.407G>C	c.(406-408)aGa>aCa	p.R136T	RSRC1_ENST00000464171.1_Intron|RSRC1_ENST00000312179.6_Intron|RSRC1_ENST00000475278.2_Missense_Mutation_p.R136T|RSRC1_ENST00000496268.1_3'UTR|RSRC1_ENST00000480820.1_Missense_Mutation_p.R136T	NM_001271838.1|NM_016625.2	NP_001258767.1|NP_057709.2	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	136	Arg/Ser-rich.				nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|upper_aerodigestive_tract(1)	18			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			TCTCGGGATAGAGAACGACGT	0.468000													5	17					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168187935	168187935	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:168187935C>T	ENST00000519560.1	-	16	2036	c.1617G>A	c.(1615-1617)ctG>ctA	p.L539L	SLIT3_ENST00000332966.8_Silent_p.L539L|SLIT3_ENST00000404867.3_Silent_p.L539L	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	539					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CATTGTCATTCAGTCGCCTGT	0.532000													27	20					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120600994	120600994	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:120600994G>T	ENST00000300648.6	-	19	1930	c.1918C>A	c.(1918-1920)Cca>Aca	p.P640T		NM_006836.1	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	640					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGGACCCGTGGAGGCACGTAG	0.562000													15	25					6.49762e-13	6.8371e-13	1	1	0
R3HCC1L	27291	broad.mit.edu	37	10	99991295	99991295	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:99991295G>C	ENST00000314594.5	+	7	2157	c.60G>C	c.(58-60)gaG>gaC	p.E20D	R3HCC1L_ENST00000370586.2_Missense_Mutation_p.E10D|R3HCC1L_ENST00000298999.3_Missense_Mutation_p.E604D|R3HCC1L_ENST00000370584.3_Missense_Mutation_p.E604D	NM_001256619.1	NP_001243548.1			R3H domain and coiled-coil containing 1-like																		AGAGCAGAGAGAGCATCCAGG	0.358000													13	47					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207758064	207758064	+	Silent	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:207758064C>A	ENST00000367049.4	+	33	5373	c.5373C>A	c.(5371-5373)ccC>ccA	p.P1791P	CR1_ENST00000367051.1_Silent_p.P1341P|CR1_ENST00000400960.2_Silent_p.P1341P|RP11-78B10.2_ENST00000597497.1_RNA|CR1_ENST00000367053.1_Silent_p.P1341P|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000367052.1_Silent_p.P1341P	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1341	Sushi 28.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GAGATATTCCCTATGGAAAAG	0.468000													45	78					2.43468e-25	2.60268e-25	1	1	0
NDUFAF5	79133	broad.mit.edu	37	20	13775549	13775549	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:13775549C>T	ENST00000378106.5	+	5	560	c.441C>T	c.(439-441)ttC>ttT	p.F147F	NDUFAF5_ENST00000463598.1_Intron|NDUFAF5_ENST00000475968.1_Intron	NM_024120.4	NP_077025.2	Q5TEU4	CT007_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5	147					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity										TCCTTCCCTTCAAAGAAAATA	0.318000													15	10					0	0	1	0	0
HAND2	9464	broad.mit.edu	37	4	174448515	174448515	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:174448515C>G	ENST00000359562.4	-	2	1506	c.567G>C	c.(565-567)ttG>ttC	p.L189F	HAND2-AS1_ENST00000512099.1_RNA	NM_021973.2	NP_068808.1	P61296	HAND2_HUMAN	heart and neural crest derivatives expressed 2	189					adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)	13		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		CTGTGCTTTTCAAGATTTCGT	0.562000													17	48					0	0	1	0	0
FAM110A	83541	broad.mit.edu	37	20	826051	826051	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:826051C>G	ENST00000304189.2	+	3	985	c.604C>G	c.(604-606)Ctc>Gtc	p.L202V	FAM110A_ENST00000381939.1_Missense_Mutation_p.L202V|FAM110A_ENST00000541082.1_Missense_Mutation_p.L202V|FAM110A_ENST00000381941.3_Missense_Mutation_p.L202V|FAM110A_ENST00000246100.3_Missense_Mutation_p.L202V			Q9BQ89	F110A_HUMAN	family with sequence similarity 110, member A	202						microtubule organizing center|spindle pole	protein binding			breast(1)|lung(2)	3						AGCCGCTGATCTCGAGCGCTT	0.672000													7	12					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75798882	75798882	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:75798882C>T	ENST00000322507.8	-	64	9259	c.8950G>A	c.(8950-8952)Gga>Aga	p.G2984R	COL12A1_ENST00000483888.2_Missense_Mutation_p.G2980R|COL12A1_ENST00000345356.6_Missense_Mutation_p.G1820R|COL12A1_ENST00000416123.2_Missense_Mutation_p.G2908R|COL12A1_ENST00000511023.1_5'UTR	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2984	Triple-helical region (COL1) with 2 imperfections.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CCTTTCTCTCCTGGCAAACCT	0.418000													5	13					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620229	7620229	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:7620229G>A	ENST00000486284.1	+	8	1910	c.1636G>A	c.(1636-1638)Gag>Aag	p.E546K	GRM7_ENST00000389336.4_Missense_Mutation_p.E546K|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000402647.2_Missense_Mutation_p.E546K|GRM7_ENST00000403881.1_Missense_Mutation_p.E546K|GRM7_ENST00000357716.4_Missense_Mutation_p.E546K	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	546					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TTGGACCTGTGAGCCTTGCGA	0.502000													28	67					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834737	125834737	+	Silent	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:125834737C>A	ENST00000299308.3	+	2	800	c.792C>A	c.(790-792)gtC>gtA	p.V264V		NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	264						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GTGTGGTGGTCTACCCAACCC	0.577000													47	86					1.31131e-34	1.40627e-34	1	1	0
SUSD4	55061	broad.mit.edu	37	1	223402708	223402708	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:223402708C>T	ENST00000343846.3	-	5	1380	c.747G>A	c.(745-747)gtG>gtA	p.V249V	SUSD4_ENST00000478605.1_Intron|SUSD4_ENST00000454695.2_Silent_p.V89V|SUSD4_ENST00000366878.4_Silent_p.V249V|SUSD4_ENST00000494793.2_Silent_p.V249V|SUSD4_ENST00000484758.2_Silent_p.V180V			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	249	Sushi 4.					integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		CTCCGTGACTCACCATTGGAG	0.542000													19	42					0	0	1	0	0
BRAT1	221927	broad.mit.edu	37	7	2578831	2578831	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:2578831C>T	ENST00000340611.4	-	13	2008	c.1752G>A	c.(1750-1752)gaG>gaA	p.E584E	BRAT1_ENST00000473879.1_Intron	NM_152743.3	NP_689956.2	Q6PJG6	BRAT1_HUMAN	BRCA1-associated ATM activator 1	584					response to ionizing radiation	nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23						CCTCTGCATGCTCAGGGCTGG	0.672000													13	19					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8100269	8100269	+	Splice_Site	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:8100269G>T	ENST00000379328.3	+	3	811	c.243G>T	c.(241-243)ggG>ggT	p.G81G	GATA3_ENST00000346208.3_Splice_Site_p.G81G	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	81					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						GCCCCACAGGGAGCCAGGTGT	0.672000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						6	41					1.12685e-05	1.14274e-05	1	1	0
ZNF107	51427	broad.mit.edu	37	7	64167065	64167065	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:64167065G>C	ENST00000395391.1	+	4	1758	c.383G>C	c.(382-384)aGa>aCa	p.R128T	ZNF107_ENST00000423627.1_Missense_Mutation_p.R128T|ZNF107_ENST00000344930.3_Missense_Mutation_p.R128T			Q9UII5	ZN107_HUMAN	zinc finger protein 107	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				ATTCATACTAGAGTGAATTCC	0.343000													8	31					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10364202	10364202	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:10364202G>C	ENST00000377093.4	+	21	3112	c.2959G>C	c.(2959-2961)Gag>Cag	p.E987Q	KIF1B_ENST00000377086.1_Intron|KIF1B_ENST00000263934.6_Intron|KIF1B_ENST00000377083.1_Missense_Mutation_p.E987Q|KIF1B_ENST00000377081.1_Intron	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TGAGGTTATAGAGCTTAGGAT	0.448000													35	55					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126133737	126133737	+	Silent	SNP	C	C	T	rs142240363		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:126133737C>T	ENST00000373631.3	+	8	2317	c.2316C>T	c.(2314-2316)ctC>ctT	p.L772L	CRB2_ENST00000373629.2_Silent_p.L440L|CRB2_ENST00000359999.3_Silent_p.L772L	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	772	Laminin G-like 2.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						ACCTGCGACTCGATGGCTGCC	0.682000													11	45					0	0	1	0	0
FOXO3	2309	broad.mit.edu	37	6	108985224	108985224	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:108985224C>T	ENST00000406360.1	+	2	1531	c.1188C>T	c.(1186-1188)ctC>ctT	p.L396L	FOXO3_ENST00000540898.1_Silent_p.L176L|FOXO3_ENST00000343882.6_Silent_p.L396L	NM_001455.3	NP_001446.1	O43524	FOXO3_HUMAN	forkhead box O3	396					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		ACATCACGCTCCCGCCATCCC	0.602000													9	24					0	0	1	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140870771	140870771	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:140870771C>T	ENST00000252087.1	+	1	1964	c.1964C>T	c.(1963-1965)tCa>tTa	p.S655L	PCDHGA12_ENST00000252085.3_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGC4_ENST00000306593.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018929.2|NM_032403.2|NM_032407.1	NP_061752.1|NP_115779.1|NP_115783.1	Q9Y5F6	PCDGM_HUMAN		655	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ggtgacccttcactctcctcc	0.577000													9	33					0	0	1	0	0
HSPH1	10808	broad.mit.edu	37	13	31728800	31728800	+	Silent	SNP	G	G	C	rs111995920		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:31728800G>C	ENST00000320027.5	-	4	743	c.399C>G	c.(397-399)ctC>ctG	p.L133L	HSPH1_ENST00000380406.5_Intron|HSPH1_ENST00000429785.2_Silent_p.L30L|HSPH1_ENST00000380405.4_Silent_p.L133L|HSPH1_ENST00000445273.2_Silent_p.L135L	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	133					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		CTGGTTTCTTGAGGCTGTTTT	0.348000													19	57					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159183116	159183116	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:159183116C>G	ENST00000297239.9	+	15	1617	c.1423C>G	c.(1423-1425)Cag>Gag	p.Q475E	SYTL3_ENST00000360448.3_Missense_Mutation_p.Q407E|SYTL3_ENST00000367081.3_Missense_Mutation_p.Q201E			Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	475	C2 2.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		AGGGACAGATCAGCCATCACT	0.483000													13	38					0	0	1	0	0
ZNF415	55786	broad.mit.edu	37	19	53612988	53612988	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:53612988C>T	ENST00000455735.2	-	7	774	c.454G>A	c.(454-456)Gaa>Aaa	p.E152K	ZNF415_ENST00000601493.1_5'UTR|ZNF415_ENST00000448501.1_Missense_Mutation_p.E152K|ZNF415_ENST00000595193.1_3'UTR|ZNF415_ENST00000440291.1_Missense_Mutation_p.E91K|ZNF415_ENST00000597748.1_3'UTR|ZNF415_ENST00000421033.1_Missense_Mutation_p.E116K|ZNF415_ENST00000243643.4_Missense_Mutation_p.E104K|ZNF415_ENST00000601215.1_3'UTR|ZNF415_ENST00000597503.1_3'UTR|ZNF415_ENST00000500065.4_Missense_Mutation_p.E104K|ZNF415_ENST00000594011.1_3'UTR			Q09FC8	ZN415_HUMAN	zinc finger protein 415	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				GBM - Glioblastoma multiforme(134;0.0191)		CAATTTCTTTCATCATCTCTC	0.373000													64	49					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54760855	54760855	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:54760855C>G	ENST00000450632.1	-	2	116	c.39G>C	c.(37-39)ctG>ctC	p.L13L	LILRB5_ENST00000345866.6_Silent_p.L13L|LILRB5_ENST00000449561.2_Silent_p.L13L|LILRB5_ENST00000316219.5_Silent_p.L13L			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	13					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGCCCACACTCAGCCCTGGAA	0.622000													25	18					0	0	1	0	0
LUC7L	55692	broad.mit.edu	37	16	249172	249172	+	Silent	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:249172G>T	ENST00000337351.4	-	6	699	c.576C>A	c.(574-576)gtC>gtA	p.V192V	LUC7L_ENST00000397783.1_Silent_p.V192V|LUC7L_ENST00000397780.1_Silent_p.V139V|LUC7L_ENST00000293872.8_Silent_p.V192V	NM_018032.3	NP_060502.1	Q9NQ29	LUC7L_HUMAN	LUC7-like (S. cerevisiae)	192							metal ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	11		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				AGGCTGAACAGACCTCGCAGA	0.483000													45	55					1.6237e-14	1.7157e-14	1	1	0
ICAM5	7087	broad.mit.edu	37	19	10402390	10402390	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:10402390G>C	ENST00000221980.4	+	3	641	c.578G>C	c.(577-579)gGa>gCa	p.G193A		NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	193	Ig-like C2-type 2.				cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			GAGGACCATGGAGCCAATTTC	0.677000													19	9					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49414970	49414970	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:49414970G>A	ENST00000374201.3	-	14	1920	c.1618C>T	c.(1618-1620)Cag>Tag	p.Q540*	FRMPD2_ENST00000407470.4_Nonsense_Mutation_p.Q508*|FRMPD2_ENST00000305531.3_Nonsense_Mutation_p.Q515*	NM_001018071.3|NM_001042512.2	NP_001018081|NP_001035977.2	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	540	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GGGAGCTGCTGAGTGACCTGG	0.502000													14	41					0	0	1	0	0
TTLL12	23170	broad.mit.edu	37	22	43569763	43569763	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:43569763C>G	ENST00000216129.6	-	9	1362	c.1299G>C	c.(1297-1299)aaG>aaC	p.K433N		NM_015140.3	NP_055955.1	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	433	TTL.				protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	13		Ovarian(80;0.221)|Glioma(61;0.222)				TGTGCAGGCTCTTGGTGACGT	0.687000													7	19					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50154457	50154457	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:50154457G>T	ENST00000360565.3	+	7	935	c.811G>T	c.(811-813)Gag>Tag	p.E271*		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	271	Glu-rich.				mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		Tgaggaggaagaggaggagga	0.617000													28	12					1.17739e-12	1.23762e-12	1	1	0
NANP	140838	broad.mit.edu	37	20	25604545	25604545	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:25604545C>G	ENST00000304788.3	-	1	266	c.40G>C	c.(40-42)Gac>Cac	p.D14H		NM_152667.2	NP_689880.1	Q8TBE9	NANP_HUMAN	N-acetylneuraminic acid phosphatase	14	Substrate binding.				N-acetylneuraminate biosynthetic process		N-acylneuraminate-9-phosphatase activity|phosphoglycolate phosphatase activity			endometrium(2)|lung(2)|prostate(1)	5						AGAGTGTTGTCCAAGTCAAAG	0.697000													5	15					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31621561	31621561	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:31621561C>G	ENST00000379416.3	-	5	359	c.311G>C	c.(310-312)aGa>aCa	p.R104T		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	104					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TTTGGCAATTCTCTCCTAAAA	0.557000													24	50					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179427540	179427540	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:179427540C>G	ENST00000589042.1	-	326	83543	c.83319G>C	c.(83317-83319)ttG>ttC	p.L27773F	TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.L18833F|TTN_ENST00000460472.2_Missense_Mutation_p.L18708F|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.L25205F|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.L26132F|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.L18900F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	26132	Fibronectin type-III 102.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTTATGGTCAAATTCACAG	0.413000													10	30					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	56994883	56994883	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:56994883C>G	ENST00000179765.5	-	23	4404		c.e23-1		BAZ2A_ENST00000551812.1_Splice_Site|BAZ2A_ENST00000379441.3_Splice_Site|BAZ2A_ENST00000553222.1_Splice_Site|BAZ2A_ENST00000549884.1_Splice_Site			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A						chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						GAGCACATCTCTGTGAGCAGA	0.582000													10	18					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39793642	39793642	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:39793642C>G	ENST00000373272.2	+	13	1692	c.1287C>G	c.(1285-1287)ttC>ttG	p.F429L	PLCG1_ENST00000373271.1_Missense_Mutation_p.F429L|PLCG1_ENST00000244007.3_Missense_Mutation_p.F429L	NM_002660.2	NP_002651.2	P19174	PLCG1_HUMAN	phospholipase C, gamma 1	429	PI-PLC X-box.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(16)|skin(6)|urinary_tract(2)	46		Myeloproliferative disorder(115;0.00878)				CCCAATACTTCAAGAAGGTGC	0.567000													11	65					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	247556	247556	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:247556C>T	ENST00000538872.1	+	4	1145	c.1027C>T	c.(1027-1029)Ctg>Ttg	p.L343L	RP11-598F7.4_ENST00000505893.2_RNA|IQSEC3_ENST00000382841.2_Silent_p.L40L|IQSEC3_ENST00000326261.4_Silent_p.L343L			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	343	IQ.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CAACTCGCTTCTGGAGAGCCG	0.662000													4	21					0	0	1	0	0
HDAC8	55869	broad.mit.edu	37	X	71715033	71715033	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:71715033C>T	ENST00000439122.2	-	5	809	c.523G>A	c.(523-525)Gtg>Atg	p.V175M	HDAC8_ENST00000373583.1_Intron|HDAC8_ENST00000373571.1_Missense_Mutation_p.V175M|HDAC8_ENST00000429103.2_De_novo_Start_InFrame|HDAC8_ENST00000373589.4_Missense_Mutation_p.V84M|HDAC8_ENST00000373573.3_Missense_Mutation_p.V175M|HDAC8_ENST00000373560.2_Intron|HDAC8_ENST00000373561.4_Missense_Mutation_p.V175M|HDAC8_ENST00000478743.1_5'UTR|HDAC8_ENST00000373559.4_Missense_Mutation_p.V84M	NM_001166419.1	NP_001159891.1	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	175	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			breast(3)|cervix(1)|endometrium(1)|lung(4)|prostate(1)	10	Renal(35;0.156)				Vorinostat(DB02546)	TCCAAATCCACGTAGAGAATA	0.423000													9	43					0	0	1	0	0
VAV2	7410	broad.mit.edu	37	9	136857321	136857321	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:136857321G>C	ENST00000371851.1	-	1	405	c.80C>G	c.(79-81)tCg>tGg	p.S27W	VAV2_ENST00000371850.3_Missense_Mutation_p.S27W|VAV2_ENST00000406606.3_Missense_Mutation_p.S27W|VAV2_ENST00000486113.1_5'UTR			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	27	CH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GACCACGGCCGAGGGCCACAC	0.711000													7	7					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18150557	18150557	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:18150557C>G	ENST00000327031.4	-	21	2827	c.2602G>C	c.(2602-2604)Gag>Cag	p.E868Q	FLII_ENST00000578558.1_Intron|FLII_ENST00000379450.4_Missense_Mutation_p.E782Q|FLII_ENST00000579294.1_Missense_Mutation_p.E857Q|FLII_ENST00000545457.2_Missense_Mutation_p.E813Q	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	868					multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					TCTTTCTTCTCGGCGTCGCGT	0.652000													15	17					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96127806	96127806	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:96127806C>G	ENST00000453304.1	-	11	2223	c.1875G>C	c.(1873-1875)aaG>aaC	p.K625N		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	625	ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CTGCCTGGTTCTTGAGCAGTA	0.552000													28	87					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90418320	90418320	+	Missense_Mutation	SNP	C	C	T	rs149622123		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:90418320C>T	ENST00000369393.3	-	51	7908	c.7793G>A	c.(7792-7794)cGa>cAa	p.R2598Q	MDN1_ENST00000428876.1_Missense_Mutation_p.R2598Q			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	2598					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CATATTCCATCGGGGATCCAG	0.418000													57	84					0	0	1	0	0
SUCO	51430	broad.mit.edu	37	1	172538243	172538243	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:172538243G>A	ENST00000367723.4	+	7	1415	c.1291G>A	c.(1291-1293)Gaa>Aaa	p.E431K	SUCO_ENST00000608151.1_Missense_Mutation_p.E432K|SUCO_ENST00000263688.3_Missense_Mutation_p.E273K|SUCO_ENST00000610051.1_Missense_Mutation_p.E236K	NM_016227.2	NP_057311.3			SUN domain containing ossification factor																		AACATTTGATGAATGGAAGAA	0.318000													34	86					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51329903	51329903	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:51329903C>G	ENST00000326856.4	-	5	718	c.589G>C	c.(589-591)Gag>Cag	p.E197Q	KLK15_ENST00000596931.1_Intron|KLK15_ENST00000301421.2_Intron|KLK15_ENST00000598239.1_Missense_Mutation_p.E198Q|KLK15_ENST00000416184.1_Intron	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	198	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CCTCTGCCCTCCGCGCCTGCA	0.577000													33	21					0	0	1	0	0
PPP2R3B	28227	broad.mit.edu	37	X	302113	302113	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:302113C>T	ENST00000390665.3	-	9	1122	c.1104G>A	c.(1102-1104)aaG>aaA	p.K368K		NM_013239.4	NP_037371.2	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'', beta	368					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			endometrium(5)|lung(5)|skin(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCTTCCCTTCCTTCTGCACTT	0.532000													43	188					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42145615	42145615	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:42145615G>A	ENST00000502486.1	-	3	1463	c.884C>T	c.(883-885)tCc>tTc	p.S295F	BEND4_ENST00000504360.1_Missense_Mutation_p.S291F	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	295										NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						CGTTGCTGGGGAAGTCCAGCC	0.552000													6	6					0	0	1	0	0
ZAK	51776	broad.mit.edu	37	2	174125863	174125863	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:174125863G>A	ENST00000375213.3	+	18	1627	c.1549G>A	c.(1549-1551)Gag>Aag	p.E517K	MLK7-AS1_ENST00000422703.1_RNA|MLTK_ENST00000409176.2_Missense_Mutation_p.E517K|MLK7-AS1_ENST00000423106.2_RNA	NM_016653.2	NP_057737.2																					TGTCACATATGAGGTAAGCTC	0.403000													7	43					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20444551	20444551	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:20444551G>A	ENST00000305051.5	+	1	949	c.874G>A	c.(874-876)Gac>Aac	p.D292N		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	292					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTACTCAGTTGACAAAGTCCT	0.428000													37	82					0	0	1	0	0
ZKSCAN3	80317	broad.mit.edu	37	6	28333425	28333425	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:28333425C>G	ENST00000377255.3	+	7	1277	c.980C>G	c.(979-981)tCa>tGa	p.S327*	ZKSCAN3_ENST00000341464.5_Nonsense_Mutation_p.S179*|ZKSCAN3_ENST00000252211.2_Nonsense_Mutation_p.S327*	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	327					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						GCTCAAAGCTCAGGCCTGAGT	0.502000													19	40					0	0	1	0	0
LUZP4	51213	broad.mit.edu	37	X	114537871	114537871	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:114537871C>G	ENST00000371920.3	+	3	237	c.230C>G	c.(229-231)tCa>tGa	p.S77*	LUZP4_ENST00000451986.2_Intron	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	77						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						AAAGGCTACTCAAGATGCAGA	0.343000													29	86					0	0	1	0	0
RASSF3	283349	broad.mit.edu	37	12	65085310	65085310	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:65085310C>A	ENST00000542104.1	+	4	638	c.518C>A	c.(517-519)cCc>cAc	p.P173H	RASSF3_ENST00000336061.2_Missense_Mutation_p.P173H	NM_178169.3	NP_835463.1	Q86WH2	RASF3_HUMAN	Ras association (RalGDS/AF-6) domain family member 3	173	Ras-associating.				signal transduction	cytoplasm|microtubule	identical protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10			Lung(2;0.00133)|LUAD - Lung adenocarcinoma(6;0.0665)|LUSC - Lung squamous cell carcinoma(43;0.132)	GBM - Glioblastoma multiforme(28;0.0611)		GTAGCAGGGCCCAGAACAGAC	0.448000													17	53					8.10497e-08	8.31978e-08	1	1	0
KRTAP4-3	85290	broad.mit.edu	37	17	39324303	39324303	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:39324303C>T	ENST00000391356.2	-	1	121	c.122G>A	c.(121-123)cGc>cAc	p.R41H		NM_033187.1	NP_149443.1	Q9BYR4	KRA43_HUMAN	keratin associated protein 4-3	41	29 X 5 AA repeats of C-C-[GIKRQVH]-[SPT]- [STA].					keratin filament		p.R41H(1)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	12		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			gcagctggggcggcagcagGT	0.652000													11	34					0	0	1	0	0
PELI1	57162	broad.mit.edu	37	2	64322060	64322060	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:64322060G>T	ENST00000358912.4	-	7	1475	c.1033C>A	c.(1033-1035)Ctg>Atg	p.L345M		NM_020651.3	NP_065702.2	Q96FA3	PELI1_HUMAN	pellino E3 ubiquitin protein ligase 1	345					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	19						CCAAGCCACAGAGGAACATAG	0.493000													22	55					1.55469e-16	1.64624e-16	1	1	0
XPC	7508	broad.mit.edu	37	3	14207074	14207074	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:14207074G>C	ENST00000285021.7	-	6	847	c.633C>G	c.(631-633)ctC>ctG	p.L211L	XPC_ENST00000449060.2_Silent_p.L174L	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	211					nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CTAGCAGGCAGAGAAGGTGAA	0.527000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				5	13					0	0	1	0	0
FEZF2	55079	broad.mit.edu	37	3	62358488	62358488	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:62358488C>T	ENST00000283268.3	-	2	350	c.56G>A	c.(55-57)gGa>gAa	p.G19E	FEZF2_ENST00000486811.1_Missense_Mutation_p.G19E|FEZF2_ENST00000475839.1_Missense_Mutation_p.G19E	NM_018008.3	NP_060478.3	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	19					transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|lung(8)|skin(1)	20		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		CGGCGACGCTCCGGCGCGCGG	0.721000													5	10					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35545130	35545130	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:35545130C>G	ENST00000262878.4	-	9	1256	c.1057G>C	c.(1057-1059)Gat>Cat	p.D353H	SAMHD1_ENST00000373694.5_Missense_Mutation_p.D138H	NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	353					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				CTTACCTTATCTCTAGCACAA	0.368000													46	271					0	0	1	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26156945	26156945	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:26156945G>C	ENST00000304218.3	+	1	387	c.327G>C	c.(325-327)aaG>aaC	p.K109N		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	109	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						AACTCAACAAGAAGGCGGCCT	0.622000													14	47					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37482402	37482402	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:37482402G>A	ENST00000381792.2	-	8	1034	c.894C>T	c.(892-894)atC>atT	p.I298I	TMPRSS6_ENST00000406856.1_Silent_p.I298I|TMPRSS6_ENST00000406725.1_Silent_p.I298I|TMPRSS6_ENST00000346753.3_Silent_p.I307I|TMPRSS6_ENST00000442782.2_Silent_p.I307I			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	307	CUB 1.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						CGACCGCCATGATGGCCCCCG	0.662000													7	3					0	0	1	0	0
GNGT2	2793	broad.mit.edu	37	17	47284217	47284217	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:47284217C>T	ENST00000511277.1	-	4	291	c.112G>A	c.(112-114)Gag>Aag	p.E38K	GNGT2_ENST00000515635.1_Missense_Mutation_p.E38K|GNGT2_ENST00000503070.1_Missense_Mutation_p.E38K|GNGT2_ENST00000300406.2_Missense_Mutation_p.E38K|GNGT2_ENST00000511673.1_Missense_Mutation_p.E38K|GNGT2_ENST00000507680.1_Missense_Mutation_p.E38K	NM_001198756.1	NP_001185685.1	O14610	GBGT2_HUMAN	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2	38					G-protein coupled receptor protein signaling pathway|phototransduction|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity			endometrium(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			TCCACGTACTCCTTGATTTCC	0.463000													25	56					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65246547	65246547	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:65246547C>T	ENST00000389722.3	-	20	4422	c.4369G>A	c.(4369-4371)Gag>Aag	p.E1457K	SPTB_ENST00000389720.3_Missense_Mutation_p.E1457K|SPTB_ENST00000556626.1_Missense_Mutation_p.E1457K|SPTB_ENST00000389721.5_Missense_Mutation_p.E1457K|SPTB_ENST00000542895.1_Missense_Mutation_p.E1457K	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1457					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton	p.E1457*(1)		breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		AACCGCTTCTCGATGCTCAAG	0.562000													35	120					0	0	1	0	0
SCUBE2	57758	broad.mit.edu	37	11	9055266	9055266	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:9055266C>A	ENST00000457346.2	-	17	2154	c.2080G>T	c.(2080-2082)Gag>Tag	p.E694*	SCUBE2_ENST00000450649.2_Nonsense_Mutation_p.E539*|SCUBE2_ENST00000309263.3_Nonsense_Mutation_p.E665*|RP11-467K18.2_ENST00000531592.1_RNA|SCUBE2_ENST00000520467.1_Intron			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	665						extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		TGTCCTTCCTCATTTTGGAAG	0.478000													51	60					7.05377e-20	7.51655e-20	1	1	0
APOB	338	broad.mit.edu	37	2	21246547	21246547	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:21246547C>T	ENST00000233242.1	-	17	2581	c.2454G>A	c.(2452-2454)agG>agA	p.R818R		NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	818					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGAGCCCTTCCTGATGACCT	0.403000													10	27					0	0	1	0	0
OAS2	4939	broad.mit.edu	37	12	113444350	113444350	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:113444350C>A	ENST00000392583.2	+	8	1808	c.1601C>A	c.(1600-1602)tCc>tAc	p.S534Y	OAS2_ENST00000342315.4_Missense_Mutation_p.S534Y|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	534	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						TTCATTCGCTCCCGGCCCACC	0.468000													53	114					9.04393e-38	9.70921e-38	1	1	0
BPHL	670	broad.mit.edu	37	6	3123966	3123966	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:3123966C>T	ENST00000380368.2	+	3	776	c.132C>T	c.(130-132)caC>caT	p.H44H	BPHL_ENST00000380379.5_Silent_p.H61H|BPHL_ENST00000434640.1_Silent_p.H44H|BPHL_ENST00000380375.3_Silent_p.H44H			Q86WA6	BPHL_HUMAN	biphenyl hydrolase-like (serine hydrolase)	61					cellular amino acid metabolic process|response to toxin	mitochondrion	hydrolase activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(6)	13	Ovarian(93;0.0386)	all_hematologic(90;0.108)				AGGGAGATCACGCAGTCCTGC	0.458000													15	40					0	0	1	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68029604	68029604	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:68029604C>T	ENST00000329153.5	+	7	1388	c.1256C>T	c.(1255-1257)tCa>tTa	p.S419L		NM_020715.2	NP_065766.1	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	419						cytoskeleton	binding			endometrium(2)|kidney(4)|lung(12)|urinary_tract(1)	19				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CACCAGTTTTCATCCTGGGTA	0.587000													10	22					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21247964	21247964	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:21247964C>T	ENST00000233242.1	-	16	2404	c.2277G>A	c.(2275-2277)gaG>gaA	p.E759E	APOB_ENST00000399256.4_Silent_p.E759E	NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	759					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TAATCAGCTTCTCAACACTGA	0.443000													19	46					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44816927	44816927	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:44816927C>G	ENST00000326047.4	+	3	393	c.244C>G	c.(244-246)Cag>Gag	p.Q82E		NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	82	Kinesin-motor.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		GGATACCACTCAGGTAATGAT	0.463000													17	38					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55555447	55555447	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:55555447G>A	ENST00000436346.1	-	17	3821	c.2980C>T	c.(2980-2982)Cgc>Tgc	p.R994C	AC012358.8_ENST00000600219.1_RNA|AC012358.8_ENST00000608103.1_RNA|CCDC88A_ENST00000263630.8_Missense_Mutation_p.R994C|CCDC88A_ENST00000413716.2_Missense_Mutation_p.R993C|AC012358.8_ENST00000599475.1_RNA|AC012358.8_ENST00000599352.1_RNA|CCDC88A_ENST00000336838.6_Missense_Mutation_p.R993C|AC012358.8_ENST00000594078.1_RNA	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	994					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						AGTTCTTGGCGCAATTGCTGG	0.274000													13	35					0	0	1	0	0
ZNF502	91392	broad.mit.edu	37	3	44762639	44762639	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:44762639G>C	ENST00000296091.4	+	4	586	c.330G>C	c.(328-330)ttG>ttC	p.L110F	ZNF502_ENST00000449836.1_Missense_Mutation_p.L110F|ZNF502_ENST00000436624.2_Missense_Mutation_p.L110F	NM_001134440.1|NM_001282880.1|NM_033210.4	NP_001127912.1|NP_001269809.1|NP_149987.2	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	110					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(8)|lung(4)|prostate(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		GCTTGCTTTTGACCTCAAGCC	0.383000													19	49					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15729039	15729039	+	RNA	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:15729039C>G	ENST00000441682.2	+	0	407							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CTGTGCAGCTCTTGTAGTACT	0.517000													11	12					0	0	1	0	0
MMP14	4323	broad.mit.edu	37	14	23315062	23315062	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:23315062G>C	ENST00000311852.6	+	10	1824	c.1563G>C	c.(1561-1563)gaG>gaC	p.E521D	MMP14_ENST00000548162.1_Intron	NM_004995.2	NP_004986.1	P50281	MMP14_HUMAN	matrix metallopeptidase 14 (membrane-inserted)	521						extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		CTGAGGAGGAGACGGAGGTGA	0.682000													13	25					0	0	1	0	0
NR1I3	9970	broad.mit.edu	37	1	161203028	161203028	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:161203028C>T	ENST00000367983.4	-	4	633	c.339G>A	c.(337-339)ctG>ctA	p.L113L	NR1I3_ENST00000367979.2_Silent_p.L113L|NR1I3_ENST00000442691.2_Silent_p.L113L|NR1I3_ENST00000412844.2_Silent_p.L84L|NR1I3_ENST00000367980.2_Silent_p.L113L|NR1I3_ENST00000502985.1_Intron|NR1I3_ENST00000515621.1_Silent_p.L38L|NR1I3_ENST00000367984.4_Silent_p.L113L|NR1I3_ENST00000504010.1_Silent_p.L84L|NR1I3_ENST00000505005.1_Silent_p.L113L|NR1I3_ENST00000437437.2_Silent_p.L84L|NR1I3_ENST00000511748.1_Intron|NR1I3_ENST00000508740.1_Silent_p.L84L|NR1I3_ENST00000508387.1_Intron|NR1I3_ENST00000428574.2_Silent_p.L113L|NR1I3_ENST00000511676.1_Silent_p.L84L|NR1I3_ENST00000367981.3_Silent_p.L84L|NR1I3_ENST00000367982.4_Silent_p.L113L|NR1I3_ENST00000506209.1_Silent_p.L84L|NR1I3_ENST00000515452.1_Silent_p.L113L|NR1I3_ENST00000511944.1_Intron|NR1I3_ENST00000512372.1_Silent_p.L84L|NR1I3_ENST00000367985.3_Silent_p.L113L			Q14994	NR1I3_HUMAN	nuclear receptor subfamily 1, group I, member 3	113					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	15	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GTGTCCGGATCAGCTCTTCTT	0.577000													20	203					0	0	1	0	0
MS4A13	503497	broad.mit.edu	37	11	60292761	60292761	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:60292761C>G	ENST00000378186.2	+	5	591	c.268C>G	c.(268-270)Cat>Gat	p.H90D	MS4A13_ENST00000527948.1_Intron|MS4A13_ENST00000378185.2_Intron|MS4A13_ENST00000437058.2_Intron	NM_001012417.2	NP_001012417.2	Q5J8X5	M4A13_HUMAN	membrane-spanning 4-domains, subfamily A, member 13	90						integral to membrane				endometrium(3)|large_intestine(1)|lung(2)|skin(2)	8						AGAGTTGTCTCATTTTAATTC	0.279000													24	58					0	0	1	0	0
MMP25	64386	broad.mit.edu	37	16	3107106	3107106	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:3107106C>T	ENST00000336577.4	+	5	971	c.734C>T	c.(733-735)tCa>tTa	p.S245L	RP11-473M20.7_ENST00000572574.1_RNA|RP11-473M20.7_ENST00000570949.1_RNA|RP11-473M20.7_ENST00000576250.1_RNA|RP11-473M20.7_ENST00000573878.1_RNA	NM_022468.4	NP_071913.1	Q9NPA2	MMP25_HUMAN	matrix metallopeptidase 25	245					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	14						GGCCACTCCTCAGCCCCCAAC	0.642000													54	85					0	0	1	0	0
HS6ST2	90161	broad.mit.edu	37	X	132091164	132091164	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:132091164G>A	ENST00000370836.2	-	3	1034	c.619C>T	c.(619-621)Cgc>Tgc	p.R207C	HS6ST2_ENST00000370833.2_Missense_Mutation_p.R61C|HS6ST2_ENST00000521489.1_Missense_Mutation_p.R207C	NM_147175.3	NP_671704.3	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2	207						integral to membrane	sulfotransferase activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(2)	9	Acute lymphoblastic leukemia(192;0.000127)					AAATTGTAGCGGGGCACGAAC	0.652000													9	24					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112048228	112048228	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:112048228G>A	ENST00000371959.3	-	5	1722	c.1723C>T	c.(1723-1725)Cga>Tga	p.R575*	AMOT_ENST00000371962.1_Nonsense_Mutation_p.R343*|AMOT_ENST00000371958.1_Nonsense_Mutation_p.R343*|AMOT_ENST00000524145.1_Nonsense_Mutation_p.R575*|AMOT_ENST00000304758.1_Nonsense_Mutation_p.R166*	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	575					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						GCCTGATCTCGGATTTCGATG	0.552000													10	170					0	0	1	0	0
SEPT3	55964	broad.mit.edu	37	22	42385679	42385679	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:42385679C>T	ENST00000396425.3	+	6	791	c.660C>T	c.(658-660)ttC>ttT	p.F220F	SEPT3_ENST00000328414.8_3'UTR|SEPT3_ENST00000396426.3_Silent_p.F220F|SEPT3_ENST00000406029.1_Silent_p.F156F|SEPT3_ENST00000291236.11_Silent_p.F156F	NM_019106.5	NP_061979.3	Q9UH03	SEPT3_HUMAN	septin 3	220					cell cycle|cytokinesis	cell junction|septin complex	GTP binding			breast(1)|kidney(3)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17						AGTCTGAATTCAAGCAAAGGG	0.517000													20	33					0	0	1	0	0
ERO1LB	56605	broad.mit.edu	37	1	236389643	236389643	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:236389643G>A	ENST00000354619.5	-	12	1179	c.978C>T	c.(976-978)gtC>gtT	p.V326V		NM_019891.3	NP_063944.3	Q86YB8	ERO1B_HUMAN	ERO1-like beta (S. cerevisiae)	326					electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding			NS(1)|endometrium(3)|large_intestine(8)|lung(8)|skin(2)|urinary_tract(1)	23	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			TGTAAAGATCGACAATTGAGC	0.378000													13	93					0	0	1	0	0
UNCX	340260	broad.mit.edu	37	7	1273317	1273317	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:1273317G>A	ENST00000316333.8	+	2	547	c.436G>A	c.(436-438)Gag>Aag	p.E146K		NM_001080461.1	NP_001073930.1	A6NJT0	UNC4_HUMAN	UNC homeobox	146					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)|skin(1)|upper_aerodigestive_tract(1)	4		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		AGACCTGGTCGAGTCCCGAGT	0.667000													24	42					0	0	1	0	0
SDCBP	6386	broad.mit.edu	37	8	59492300	59492300	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:59492300C>T	ENST00000523483.1	+	8	2271	c.757C>T	c.(757-759)Ctc>Ttc	p.L253F	SDCBP_ENST00000447267.2_Missense_Mutation_p.L179F|SDCBP_ENST00000424270.2_Missense_Mutation_p.L227F|SDCBP_ENST00000447182.2_Missense_Mutation_p.L232F|SDCBP_ENST00000520168.1_Missense_Mutation_p.L174F|SDCBP_ENST00000422546.2_Missense_Mutation_p.L232F|SDCBP_ENST00000260130.4_Missense_Mutation_p.L233F|SDCBP_ENST00000413219.2_Missense_Mutation_p.L233F			O00560	SDCB1_HUMAN	syndecan binding protein (syntenin)	233	PDZ 2.				actin cytoskeleton organization|axon guidance|positive regulation of phosphorylation|protein targeting to membrane|substrate-dependent cell migration, cell extension|synaptic transmission	cytoskeleton|cytosol|endoplasmic reticulum membrane|focal adhesion|interleukin-5 receptor complex|melanosome|nucleus	cytoskeletal adaptor activity|frizzled binding|interleukin-5 receptor binding|protein heterodimerization activity|protein N-terminus binding|syndecan binding			breast(1)|cervix(2)|kidney(1)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(1)	8		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				AAATGGTCTTCTCACGGAACA	0.378000													10	88					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75277138	75277138	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:75277138C>G	ENST00000339859.4	-	19	3146	c.3046G>C	c.(3046-3048)Gaa>Caa	p.E1016Q	RP11-137L10.6_ENST00000597958.1_RNA|USP54_ENST00000497106.1_5'UTR|RP11-137L10.6_ENST00000595069.1_RNA|RP11-137L10.6_ENST00000600206.1_RNA|USP54_ENST00000394811.2_Missense_Mutation_p.E104Q|RP11-137L10.6_ENST00000593790.1_RNA|USP54_ENST00000422491.2_Missense_Mutation_p.E198Q|USP54_ENST00000408019.1_Missense_Mutation_p.E1016Q|USP54_ENST00000428547.1_Missense_Mutation_p.E866Q			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	1016					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					CCTCTTCCTTCTTGTGGAGGG	0.527000													21	72					0	0	1	0	0
SUPT20H	55578	broad.mit.edu	37	13	37603941	37603941	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:37603941G>A	ENST00000360252.4	-	13	1204	c.957C>T	c.(955-957)atC>atT	p.I319I	SUPT20H_ENST00000464744.1_Silent_p.I319I|SUPT20H_ENST00000542180.1_Intron|SUPT20H_ENST00000350612.6_Silent_p.I318I|SUPT20H_ENST00000356185.3_Silent_p.I319I|SUPT20H_ENST00000475892.1_Silent_p.I318I	NM_001278481.1|NM_001278482.1|NM_017569.3	NP_001265410.1|NP_001265411.1|NP_060039.1			suppressor of Ty 20 homolog (S. cerevisiae)																		CATCAGATTTGATAGACTTTT	0.358000													21	33					0	0	1	0	0
EPCAM	4072	broad.mit.edu	37	2	47601063	47601063	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:47601063G>C	ENST00000263735.4	+	3	659	c.301G>C	c.(301-303)Gag>Cag	p.E101Q	EPCAM_ENST00000405271.1_Missense_Mutation_p.E129Q	NM_002354.2	NP_002345.2	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule	101	Thyroglobulin type-1.				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding	p.0?(2)|p.?(1)		endometrium(3)|large_intestine(1)|liver(2)|lung(7)|skin(1)|stomach(1)	15						TGACTGCGATGAGAGCGGGCT	0.507000													11	25					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131191267	131191267	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:131191267C>G	ENST00000337057.3	-	15	2225		c.e15-1		EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000525193.1_Intron|EPB41L2_ENST00000529208.1_Splice_Site|EPB41L2_ENST00000530481.1_Splice_Site|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000445890.2_Intron|EPB41L2_ENST00000531410.1_Intron|EPB41L2_ENST00000368128.2_Splice_Site|EPB41L2_ENST00000527659.1_Splice_Site|EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000528282.1_Intron|EPB41L2_ENST00000524581.1_Splice_Site|EPB41L2_ENST00000527411.1_Splice_Site	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2						cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CATGTGAACTCTGTACAAAAA	0.363000													11	29					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150327218	150327218	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:150327218C>G	ENST00000328902.5	-	2	229	c.13G>C	c.(13-15)Gaa>Caa	p.E5Q	GIMAP6_ENST00000493969.1_Missense_Mutation_p.E5Q	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	5							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGTTCATATTCTTCTTCCTCC	0.423000													12	55					0	0	1	0	0
CXorf38	159013	broad.mit.edu	37	X	40506390	40506390	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:40506390G>A	ENST00000327877.5	-	2	246	c.220C>T	c.(220-222)Cag>Tag	p.Q74*	CXorf38_ENST00000378421.1_5'UTR|CXorf38_ENST00000378418.2_Nonsense_Mutation_p.Q74*|CXorf38_ENST00000378426.1_5'UTR|CXorf38_ENST00000440784.2_Intron	NM_144970.2	NP_659407.1	Q8TB03	CX038_HUMAN	chromosome X open reading frame 38	74										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	12						CACTGAGGCTGAAACTACAGG	0.627000													17	32					0	0	1	0	0
DHX8	1659	broad.mit.edu	37	17	41585254	41585254	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:41585254C>T	ENST00000262415.3	+	15	2259	c.2187C>T	c.(2185-2187)ttC>ttT	p.F729F	DHX8_ENST00000540306.1_Silent_p.F729F	NM_004941.1	NP_004932.1	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	729	Helicase ATP-binding.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		CTCAATACTTCTATGAAGCTC	0.438000													26	68					0	0	1	0	0
MSI2	124540	broad.mit.edu	37	17	55693436	55693436	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:55693436G>C	ENST00000284073.2	+	9	852	c.643G>C	c.(643-645)Ggg>Cgg	p.G215R	MSI2_ENST00000416426.2_Missense_Mutation_p.G193R|MSI2_ENST00000579505.1_3'UTR|MSI2_ENST00000579180.1_Missense_Mutation_p.G111R|MSI2_ENST00000322684.3_Missense_Mutation_p.G211R|MSI2_ENST00000442934.2_Missense_Mutation_p.G154R	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	215						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		GCTTGGCATGGGGATGCTGGG	0.592000			T	HOXA9	CML								26	38					0	0	1	0	0
BTG1	694	broad.mit.edu	37	12	92538201	92538201	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:92538201G>T	ENST00000256015.3	-	2	532	c.171C>A	c.(169-171)ttC>ttA	p.F57L		NM_001731.2	NP_001722.1	P62324	BTG1_HUMAN	B-cell translocation gene 1, anti-proliferative	57					cell migration|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of endothelial cell differentiation|positive regulation of myoblast differentiation|regulation of apoptosis|regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|transcription cofactor activity			haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(1)|lung(2)	16		Acute lymphoblastic leukemia(6;3.02e-13)|all_hematologic(6;4.32e-09)				GCTTTTCTGGGAACCAGTGAT	0.473000			T	MYC	BCLL						OREG0022024	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	50					4.31634e-10	4.49024e-10	1	1	0
PRKRIR	5612	broad.mit.edu	37	11	76062333	76062333	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:76062333C>G	ENST00000260045.3	-	5	1966	c.1861G>C	c.(1861-1863)Gag>Cag	p.E621Q		NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	621					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						TGGTGTTCCTCCGACGTATTG	0.433000													4	376					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17305933	17305933	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:17305933G>A	ENST00000595618.1	+	22	3849	c.3697G>A	c.(3697-3699)Gaa>Aaa	p.E1233K	MYO9B_ENST00000594824.1_Missense_Mutation_p.E1233K|MYO9B_ENST00000397274.2_Missense_Mutation_p.E1233K	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	1233	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						GGTCTCTGAAGAAACTGAGAA	0.622000													4	11					0	0	1	0	0
ZNF689	115509	broad.mit.edu	37	16	30620934	30620934	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:30620934G>A	ENST00000287461.3	-	2	568	c.231C>T	c.(229-231)ctC>ctT	p.L77L	ZNF689_ENST00000566673.1_5'UTR	NM_138447.1	NP_612456.1	Q96CS4	ZN689_HUMAN	zinc finger protein 689	77	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(1)	14			Colorectal(24;0.198)			ACCAGGAGATGAGGGCTGGTT	0.572000													26	69					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38536402	38536402	+	Missense_Mutation	SNP	C	C	T	rs139881250	byFrequency	TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr21:38536402C>T	ENST00000399017.2	+	32	5967	c.3220C>T	c.(3220-3222)Cgg>Tgg	p.R1074W	TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000354749.2_Missense_Mutation_p.R1074W|TTC3_ENST00000355666.1_Missense_Mutation_p.R1074W	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1074					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				TGACCATCTTCGGCAAGATGT	0.408000													9	64					0	0	1	0	0
CLEC1A	51267	broad.mit.edu	37	12	10233965	10233965	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:10233965G>C	ENST00000315330.4	-	3	324	c.262C>G	c.(262-264)Caa>Gaa	p.Q88E	CLEC1A_ENST00000420265.2_Intron|CLEC1A_ENST00000457018.2_Missense_Mutation_p.Q55E	NM_016511.2	NP_057595.2	Q8NC01	CLC1A_HUMAN	C-type lectin domain family 1, member A	88					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	23						TCTTCCATTTGAGAAATGGTG	0.398000													18	29					0	0	1	0	0
BNIP3P1	319138	broad.mit.edu	37	14	28733713	28733713	+	RNA	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:28733713C>T	ENST00000550043.1	+	0	118																											GAAGCACATCCCGCAGCCCGG	0.756000													3	6					0	0	1	0	0
ZAK	51776	broad.mit.edu	37	2	174125838	174125838	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:174125838G>C	ENST00000375213.3	+	18	1602	c.1524G>C	c.(1522-1524)caG>caC	p.Q508H	MLK7-AS1_ENST00000422703.1_RNA|MLTK_ENST00000409176.2_Missense_Mutation_p.Q508H|MLK7-AS1_ENST00000423106.2_RNA	NM_016653.2	NP_057737.2																					CAAAAAGTCAGACTGTGGAGT	0.418000													12	44					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22277027	22277027	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:22277027G>A	ENST00000324559.8	+	13	1608	c.1291G>A	c.(1291-1293)Gaa>Aaa	p.E431K		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	431						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ACCAGAATTTGAAGCTATGTG	0.428000													21	296					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121237430	121237430	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:121237430C>G	ENST00000297848.3	+	15	2111	c.1841C>G	c.(1840-1842)cCt>cGt	p.P614R	COL14A1_ENST00000309791.4_Missense_Mutation_p.P614R|COL14A1_ENST00000537875.1_3'UTR|COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000247781.3_Missense_Mutation_p.P519R	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	614	Fibronectin type-III 4.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CAGTCAGAGCCTCTGACTGGA	0.423000													21	36					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167083028	167083028	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:167083028G>C	ENST00000361200.2	+	3	358	c.192G>C	c.(190-192)caG>caC	p.Q64H	DUSP27_ENST00000271385.5_Missense_Mutation_p.Q64H|DUSP27_ENST00000443333.1_Missense_Mutation_p.Q64H			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	64					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CAGCCAAACAGATCATCAATG	0.473000													118	192					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206023476	206023476	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:206023476C>A	ENST00000406610.2	+	11	1672	c.1465C>A	c.(1465-1467)Ctg>Atg	p.L489M	PARD3B_ENST00000358768.2_Intron|PARD3B_ENST00000351153.1_Missense_Mutation_p.L489M|PARD3B_ENST00000462231.1_Missense_Mutation_p.L489M|PARD3B_ENST00000349953.3_Missense_Mutation_p.L489M	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	489					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		TGCACTCTCTCTGGAGACAAG	0.468000													37	89					5.78141e-17	6.14123e-17	1	1	0
CD1E	913	broad.mit.edu	37	1	158325250	158325250	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:158325250C>G	ENST00000444681.2	+	2	512	c.219C>G	c.(217-219)ctC>ctG	p.L73L	CD1E_ENST00000368167.3_Silent_p.L172L|CD1E_ENST00000368165.3_Intron|CD1E_ENST00000368163.3_Silent_p.L172L|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368160.3_Silent_p.L172L|CD1E_ENST00000368156.1_Intron|CD1E_ENST00000434258.1_Silent_p.L170L|CD1E_ENST00000368161.3_Silent_p.L172L|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368166.3_Intron	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	172					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					GTAAAGTGCTCAATCGCTACC	0.498000													31	58					0	0	1	0	0
GINM1	116254	broad.mit.edu	37	6	149901794	149901794	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:149901794G>T	ENST00000367419.5	+	6	773	c.652G>T	c.(652-654)Gaa>Taa	p.E218*		NM_138785.3	NP_620140.1			glycoprotein integral membrane 1																		CACTGTAGATGAAGATGTTTT	0.408000													23	50					3.5997e-14	3.79968e-14	1	1	0
CARF	79800	broad.mit.edu	37	2	203820396	203820396	+	Splice_Site	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:203820396G>T	ENST00000402905.3	+	7	878		c.e7-1		CARF_ENST00000320443.8_Splice_Site|CARF_ENST00000444724.1_Splice_Site|CARF_ENST00000428585.1_Splice_Site|CARF_ENST00000471271.1_Splice_Site|CARF_ENST00000434998.1_Splice_Site|CARF_ENST00000438828.2_Splice_Site|CARF_ENST00000545253.1_Splice_Site|WDR12_ENST00000477723.1_Intron|CARF_ENST00000456821.2_Splice_Site|CARF_ENST00000414439.1_Splice_Site|CARF_ENST00000545262.1_Splice_Site	NM_001104586.1|NM_001282910.1|NM_001282911.1|NM_001282912.1	NP_001098056.1|NP_001269839.1|NP_001269840.1|NP_001269841.1			calcium responsive transcription factor																		TCCTATCCCAGAATGCTGGAA	0.398000													14	44					0.000219431	0.000221855	1	1	0
FREM2	341640	broad.mit.edu	37	13	39262679	39262679	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:39262679G>A	ENST00000280481.7	+	1	1414	c.1198G>A	c.(1198-1200)Gaa>Aaa	p.E400K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	400					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GCCCCCTTCTGAAGACTCTGA	0.557000													12	81					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44577852	44577852	+	Silent	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:44577852G>T	ENST00000322927.2	-	27	3958	c.3858C>A	c.(3856-3858)gtC>gtA	p.V1286V	ZNF335_ENST00000426788.1_Silent_p.V1131V	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1286	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GAGCCTGTGTGACAAGCTGCT	0.592000													8	22					1.06961e-07	1.09573e-07	1	1	0
COL4A1	1282	broad.mit.edu	37	13	110829254	110829254	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:110829254C>T	ENST00000375820.4	-	34	2968	c.2847G>A	c.(2845-2847)caG>caA	p.Q949Q		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	949	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGTCTCCTTTCTGGCCCTTCA	0.557000													23	54					0	0	1	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41800562	41800562	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:41800562C>T	ENST00000392006.3	+	10	1662	c.1489C>T	c.(1489-1491)Cgc>Tgc	p.R497C	HNRNPUL1_ENST00000602130.1_Missense_Mutation_p.R497C|HNRNPUL1_ENST00000593587.1_Missense_Mutation_p.R397C|HNRNPUL1_ENST00000378215.4_Missense_Mutation_p.R383C|HNRNPUL1_ENST00000595018.1_Missense_Mutation_p.R397C|HNRNPUL1_ENST00000263367.3_Missense_Mutation_p.R408C|HNRNPUL1_ENST00000352456.3_Missense_Mutation_p.R397C	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	497	Necessary for interaction with BRD7 and transcriptional activation.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						GATTGCTGCCCGCAAGAAACG	0.572000													36	17					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53726146	53726146	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:53726146C>T	ENST00000262135.4	-	4	454	c.361G>A	c.(361-363)Gag>Aag	p.E121K	RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.E121K|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.E121K|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.E121K	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	121					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				TTTTCAAGCTCATGAACTTTC	0.443000													56	129					0	0	1	0	0
TSPYL2	64061	broad.mit.edu	37	X	53115045	53115045	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:53115045G>A	ENST00000375442.4	+	6	1603	c.1471G>A	c.(1471-1473)Gag>Aag	p.E491K		NM_022117.3	NP_071400.1	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	491	Asn-rich.				cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)	19						CCCcaacaacgagaccactga	0.463000													10	31					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71683215	71683215	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:71683215G>A	ENST00000393524.2	-	17	4082	c.3349C>T	c.(3349-3351)Cct>Tct	p.P1117S	PHLPP2_ENST00000356272.3_Missense_Mutation_p.P1184S|PHLPP2_ENST00000567016.1_Missense_Mutation_p.P1219S|PHLPP2_ENST00000568954.1_Missense_Mutation_p.P1184S|PHLPP2_ENST00000540628.1_Intron|PHLPP2_ENST00000360429.3_Intron			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	1184						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						TCTATGAGAGGGGGTGAGTTC	0.532000													25	99					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427505	135427505	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:135427505C>T	ENST00000394143.1	+	6	1931	c.1640C>T	c.(1639-1641)tCc>tTc	p.S547F	GPR112_ENST00000287534.4_Missense_Mutation_p.S484F|GPR112_ENST00000394141.1_Missense_Mutation_p.S342F|GPR112_ENST00000412101.1_Missense_Mutation_p.S342F|GPR112_ENST00000370652.1_Missense_Mutation_p.S547F	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	547					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					ATGTCTACTTCCATGTCGAAA	0.423000													19	54					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154132253	154132253	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:154132253G>T	ENST00000360256.4	-	18	6126	c.5926C>A	c.(5926-5928)Cat>Aat	p.H1976N		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1976	F5/8 type A 3.|Plastocyanin-like 6.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CCACTGAAATGAATAGAATGG	0.403000													26	71					3.28513e-13	3.46038e-13	1	1	0
SRRT	51593	broad.mit.edu	37	7	100473224	100473224	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:100473224G>A	ENST00000388793.4	+	2	233	c.13G>A	c.(13-15)Gat>Aat	p.D5N	SRRT_ENST00000432932.1_Missense_Mutation_p.D5N|SRRT_ENST00000457580.2_Missense_Mutation_p.D5N|SRRT_ENST00000347433.4_Missense_Mutation_p.D5N	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	5					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						GGGTGACAGTGATGACGAGTA	0.632000													7	54					0	0	1	0	0
ARHGEF18	23370	broad.mit.edu	37	19	7505313	7505313	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:7505313C>G	ENST00000359920.6	+	1	740	c.487C>G	c.(487-489)Cag>Gag	p.Q163E	CTD-2207O23.3_ENST00000593531.1_Silent_p.L120L|ARHGEF18_ENST00000319670.9_Missense_Mutation_p.Q5E	NM_001130955.1	NP_001124427.1	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 18	163					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	23		Renal(5;0.0902)				GACGGTCTCTCAGAAAGGGGG	0.677000													7	23					0	0	1	0	0
ATRAID	51374	broad.mit.edu	37	2	27438518	27438518	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:27438518C>G	ENST00000380171.3	+	5	726	c.549C>G	c.(547-549)gtC>gtG	p.V183V	ATRAID_ENST00000606999.1_Silent_p.V128V|ATRAID_ENST00000405489.3_Silent_p.V70V	NM_080592.3	NP_542159.3			all-trans retinoic acid-induced differentiation factor																		CACAACATGTCAACTGTCCTG	0.418000													48	126					0	0	1	0	0
NUDT16L1	84309	broad.mit.edu	37	16	4745141	4745141	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:4745141G>A	ENST00000304301.6	+	3	630	c.597G>A	c.(595-597)caG>caA	p.Q199Q	NUDT16L1_ENST00000586252.1_Silent_p.Q159Q|NUDT16L1_ENST00000405142.1_3'UTR|NUDT16L1_ENST00000586536.1_3'UTR	NM_032349.3	NP_115725.1	Q9BRJ7	SDOS_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1	199	Interaction with PXN (By similarity).					cytoplasm	hydrolase activity			endometrium(1)|large_intestine(1)|lung(1)|skin(1)	4						CCGAGAAGCAGAAGAAGGCCC	0.617000													25	56					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932769	83932769	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:83932769G>C	ENST00000345382.2	-	4	1319	c.1234C>G	c.(1234-1236)Cgg>Ggg	p.R412G	BNC1_ENST00000569704.1_Missense_Mutation_p.R405G|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	412					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						ATGTGCAGCCGAGGGTTGGGG	0.532000													42	87					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71148004	71148004	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:71148004G>C	ENST00000283228.2	-	5	1157	c.705C>G	c.(703-705)ctC>ctG	p.L235L	PTPRR_ENST00000378778.1_Silent_p.L29L|PTPRR_ENST00000549308.1_5'UTR|PTPRR_ENST00000440835.2_5'UTR|PTPRR_ENST00000342084.4_Silent_p.L123L	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	235					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CAAAGATGCTGAGAAAAATGA	0.353000													19	49					0	0	1	0	0
AKT3	10000	broad.mit.edu	37	1	243858964	243858964	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:243858964G>A	ENST00000366539.1	-	3	301	c.101C>T	c.(100-102)tCa>tTa	p.S34L	AKT3_ENST00000366540.1_Missense_Mutation_p.S34L|AKT3_ENST00000336199.5_Missense_Mutation_p.S34L|AKT3_ENST00000263826.5_Missense_Mutation_p.S34L			Q9Y243	AKT3_HUMAN	v-akt murine thymoma viral oncogene homolog 3	34	PH.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|skin(3)|stomach(1)	26	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			TCCTATGAATGAGCCATCTGT	0.353000													18	30					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4285427	4285427	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:4285427C>G	ENST00000404826.2	+	44	6510	c.6371C>G	c.(6370-6372)tCa>tGa	p.S2124*	SDK1_ENST00000389531.3_Nonsense_Mutation_p.S2104*|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2124					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GCAGATGCATCAGAATCTGAG	0.582000													13	33					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166891838	166891838	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:166891838G>A	ENST00000271417.3	-	8	1258	c.1203C>T	c.(1201-1203)ttC>ttT	p.F401F	ILDR2_ENST00000529071.1_Silent_p.F382F|ILDR2_ENST00000529387.1_Intron|ILDR2_ENST00000525740.1_Silent_p.F274F|ILDR2_ENST00000528703.1_Silent_p.F342F|ILDR2_ENST00000469934.2_Silent_p.F401F|ILDR2_ENST00000526687.1_Silent_p.F293F	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	401						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						ACCTGTGCCTGAAGCTCTCTC	0.592000													30	287					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201984394	201984394	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:201984394G>C	ENST00000359651.3	+	8	4251	c.1059G>C	c.(1057-1059)aaG>aaC	p.K353N	ELF3_ENST00000367284.5_Missense_Mutation_p.K353N|ELF3_ENST00000367283.3_Missense_Mutation_p.K353N|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	353					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						TCGTCTACAAGTTTGGCAAAA	0.542000													34	53					0	0	1	0	0
SBNO1	55206	broad.mit.edu	37	12	123780593	123780593	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:123780593C>G	ENST00000420886.2	-	31	4043	c.4044G>C	c.(4042-4044)ttG>ttC	p.L1348F	SBNO1_ENST00000267176.4_Missense_Mutation_p.L1347F|SBNO1_ENST00000602750.1_Missense_Mutation_p.L1347F|SBNO1_ENST00000602398.1_Missense_Mutation_p.L1348F	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1348							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CCGGAATGATCAAACCTGTAA	0.413000													32	60					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116049005	116049005	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:116049005G>A	ENST00000603594.1	+	12	2200	c.1879G>A	c.(1879-1881)Ggt>Agt	p.G627S	VWA2_ENST00000392982.3_Missense_Mutation_p.G627S	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	627	VWFA 3.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		CGTCCAGAGGGGTGCCCGGCC	0.642000													4	6					0	0	1	0	0
SYNDIG1	79953	broad.mit.edu	37	20	24646031	24646031	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:24646031C>G	ENST00000376862.3	+	4	1301	c.668C>G	c.(667-669)tCc>tGc	p.S223C		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	223					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						AGCACCAGCTCCCGGCGGGCC	0.582000													72	42					0	0	1	0	0
MGAT4B	11282	broad.mit.edu	37	5	179228820	179228820	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:179228820C>G	ENST00000337755.5	-	1	1178	c.292G>C	c.(292-294)Gac>Cac	p.D98H	MGAT4B_ENST00000292591.7_Missense_Mutation_p.D83H|MGAT4B_ENST00000521305.1_5'UTR	NM_054013.3	NP_463459.1	Q9UQ53	MGT4B_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B	83					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	13	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCGTCTCCGTCTCGCAGCGCC	0.652000											OREG0017110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	8					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76313930	76313930	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:76313930C>G	ENST00000263187.3	+	8	1303	c.1199C>G	c.(1198-1200)tCt>tGt	p.S400C		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	400					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						CAGCTTCTTTCTGTTTTAGTC	0.274000								Mismatch excision repair (MMR)					31	66					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35391853	35391853	+	Silent	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:35391853C>A	ENST00000311565.4	+	7	904	c.555C>A	c.(553-555)gcC>gcA	p.A185A	PPARD_ENST00000360694.3_Silent_p.A185A|PPARD_ENST00000448077.2_Silent_p.A146A|PPARD_ENST00000444397.1_Silent_p.A185A|PPARD_ENST00000337400.2_Silent_p.A185A|PPARD_ENST00000540939.1_Silent_p.A82A|PPARD_ENST00000418635.2_Silent_p.A87A	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	185					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	TCTACAATGCCTACCTGAAAA	0.572000													19	45					4.35082e-09	4.49361e-09	1	1	0
GSTK1	373156	broad.mit.edu	37	7	142965881	142965881	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:142965881G>C	ENST00000479303.1	+	7	858	c.800G>C	c.(799-801)gGa>gCa	p.G267A	AC073342.12_ENST00000427392.1_RNA|GSTK1_ENST00000409500.3_Splice_Site_p.G199A|GSTK1_ENST00000443571.2_Splice_Site_p.G168A|GSTK1_ENST00000358406.5_Splice_Site_p.G211A	NM_001143679.1	NP_001137151.1	Q9Y2Q3	GSTK1_HUMAN	glutathione S-transferase kappa 1	211						outer membrane-bounded periplasmic space|peroxisome	glutathione transferase activity|identical protein binding|protein disulfide oxidoreductase activity			lung(4)	4	Melanoma(164;0.059)				Glutathione(DB00143)	CTTCATCCAGGAGAGAAGTGG	0.493000													9	28					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59211339	59211339	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:59211339C>T	ENST00000302030.2	+	1	723	c.698C>T	c.(697-699)tCa>tTa	p.S233L		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						AAGATCCCTTCAGCAGAGGGC	0.542000													61	91					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35835331	35835331	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:35835331C>G	ENST00000187397.4	+	20	2776	c.2320C>G	c.(2320-2322)Cag>Gag	p.Q774E	ARPP21_ENST00000417925.1_Missense_Mutation_p.Q775E|ARPP21_ENST00000444190.1_Missense_Mutation_p.Q755E|ARPP21_ENST00000337271.5_Missense_Mutation_p.Q755E|ARPP21_ENST00000476052.1_3'UTR|ARPP21_ENST00000458225.1_Missense_Mutation_p.Q775E	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	774						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						GCCCACCCCTCAGAACAACCT	0.537000													20	41					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146829353	146829353	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:146829353C>G	ENST00000361727.3	+	8	1616	c.1100C>G	c.(1099-1101)tCt>tGt	p.S367C		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	367	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTGAGCTTTTCTTGTGTGGAA	0.438000										HNSCC(39;0.1)			46	83					0	0	1	0	0
SERTAD2	9792	broad.mit.edu	37	2	64863099	64863099	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:64863099C>G	ENST00000313349.3	-	2	1204	c.907G>C	c.(907-909)Gag>Cag	p.E303Q		NM_014755.2	NP_055570.1	Q14140	SRTD2_HUMAN	SERTA domain containing 2	303					negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus				breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|skin(1)	12						TGGTCCAGCTCTGTGAGGTCC	0.562000													9	58					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152082861	152082861	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:152082861C>G	ENST00000368804.1	-	2	2831	c.2832G>C	c.(2830-2832)ctG>ctC	p.L944L		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	944	10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding	p.L944L(1)		NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTTCCTCTCTCAGCAGCTGCT	0.562000													98	197					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51080434	51080434	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:51080434C>T	ENST00000301180.5	+	12	1554	c.1520C>T	c.(1519-1521)tCa>tTa	p.S507L		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	507						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						CCACACATCTCACCTGCTGGG	0.453000													3	29					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15728951	15728951	+	RNA	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:15728951C>T	ENST00000441682.2	+	0	403							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						TCATCAATACCTCAGGTACTC	0.547000													15	98					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189899696	189899696	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:189899696G>C	ENST00000374866.3	-	53	4573	c.4299C>G	c.(4297-4299)atC>atG	p.I1433M		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1433	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCTCTGCTTTGATATCTAAGT	0.363000													11	103					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9257709	9257709	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:9257709C>A	ENST00000262126.4	+	9	4684	c.4444C>A	c.(4444-4446)Ccg>Acg	p.P1482T	ANKRD12_ENST00000383440.2_Missense_Mutation_p.P1459T|ANKRD12_ENST00000400020.3_Missense_Mutation_p.P1459T	NM_015208.4	NP_056023.3	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12							nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						TGCTCAGGATCCGGCATCCTT	0.418000													14	55					9.16793e-09	9.44944e-09	1	1	0
ZNF106	64397	broad.mit.edu	37	15	42714754	42714754	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:42714754C>T	ENST00000263805.4	-	15	5575	c.5249G>A	c.(5248-5250)gGa>gAa	p.G1750E	ZNF106_ENST00000565380.1_Missense_Mutation_p.G978E|ZNF106_ENST00000565611.1_Missense_Mutation_p.G935E|ZNF106_ENST00000565660.1_5'UTR	NM_001284306.1|NM_001284307.1|NM_022473.1	NP_001271235.1|NP_001271236.1|NP_071918.1			zinc finger protein 106																		CATCACTTTTCCTAGGATATT	0.408000													18	35					0	0	1	0	0
SMC3	9126	broad.mit.edu	37	10	112360819	112360819	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:112360819C>G	ENST00000361804.4	+	23	2701	c.2575C>G	c.(2575-2577)Ctc>Gtc	p.L859V		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	859					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		GGGTACTGTTCTCACAGCCAC	0.343000													33	69					0	0	1	0	0
CXCL12	6387	broad.mit.edu	37	10	44871472	44871472	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:44871472C>T	ENST00000374426.2	-	4	312	c.275G>A	c.(274-276)aGa>aAa	p.R92K	CXCL12_ENST00000374429.2_Intron|CXCL12_ENST00000395793.3_Intron|CXCL12_ENST00000395795.4_Intron	NM_001033886.2	NP_001029058.1	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12	0					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity			endometrium(1)|large_intestine(1)|lung(3)|skin(1)	6					Dexamethasone(DB01234)	TTTTTCTTCTCTGCGCCCCCT	0.398000													25	79					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50827183	50827183	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:50827183C>T	ENST00000376959.2	-	2	1190	c.1027G>A	c.(1027-1029)Gag>Aag	p.E343K	KCNC3_ENST00000391818.2_Intron|KCNC3_ENST00000477616.1_Missense_Mutation_p.E343K|KCNC3_ENST00000474951.1_Intron			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	343					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GGCTCCGTCTCCACCTCCACG	0.597000													6	40					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5540382	5540382	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:5540382G>A	ENST00000382368.3	-	3	1641	c.1518C>T	c.(1516-1518)atC>atT	p.I506I	FBXL18_ENST00000453700.3_Silent_p.I506I	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	506									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GCGAGTTGCGGATGGCGGGCT	0.667000													5	13					0	0	1	0	0
AMD1	262	broad.mit.edu	37	6	111213515	111213515	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:111213515C>T	ENST00000368885.3	+	6	820	c.484C>T	c.(484-486)Ctg>Ttg	p.L162L	AMD1_ENST00000368876.1_Silent_p.L93L|AMD1_ENST00000368877.5_Silent_p.L133L|AMD1_ENST00000368882.3_Silent_p.L14L|AMD1_ENST00000451850.2_Silent_p.L42L	NM_001634.4	NP_001625.2	P17707	DCAM_HUMAN	adenosylmethionine decarboxylase 1	162					spermidine biosynthetic process|spermine biosynthetic process	cytosol	adenosylmethionine decarboxylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(2)	8		all_cancers(87;3.83e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.0522)|Epithelial(106;0.111)|all cancers(137;0.143)	S-Adenosylmethionine(DB00118)	CTTATATACTCTGGATTTCCC	0.353000													22	68					0	0	1	0	0
PPP1R26	9858	broad.mit.edu	37	9	138377703	138377703	+	Silent	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:138377703C>A	ENST00000356818.2	+	4	1896	c.1347C>A	c.(1345-1347)ctC>ctA	p.L449L	PPP1R26_ENST00000602993.1_Intron|PPP1R26_ENST00000605286.1_Silent_p.L449L|PPP1R26_ENST00000604351.1_Silent_p.L449L|PPP1R26_ENST00000401470.3_Silent_p.L449L|PPP1R26_ENST00000605660.1_Silent_p.L449L	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	449						nucleolus	protein binding										CCCCCAAGCTCCTGAAGGAAA	0.602000													17	9					3.41278e-10	3.55395e-10	1	1	0
SLC2A10	81031	broad.mit.edu	37	20	45355615	45355615	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:45355615C>T	ENST00000359271.2	+	3	1651	c.1401C>T	c.(1399-1401)ctC>ctT	p.L467L		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	467						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				TCTCCTTCCTCGATCTCATTG	0.493000													63	57					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179427150	179427150	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:179427150C>G	ENST00000589042.1	-	326	83933	c.83709G>C	c.(83707-83709)caG>caC	p.Q27903H	TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.Q18963H|TTN_ENST00000460472.2_Missense_Mutation_p.Q18838H|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.Q25335H|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.Q26262H|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.Q19030H	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	26262	Fibronectin type-III 103.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCCTTTAGTCTGCATTTCAA	0.423000													19	29					0	0	1	0	0
TTI2	80185	broad.mit.edu	37	8	33367320	33367320	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:33367320G>A	ENST00000431156.2	-	3	1396	c.778C>T	c.(778-780)Cag>Tag	p.Q260*	TTI2_ENST00000360742.5_Nonsense_Mutation_p.Q260*|TTI2_ENST00000520636.1_Nonsense_Mutation_p.Q260*	NM_001102401.2	NP_001095871.1	Q6NXR4	CH041_HUMAN	TELO2 interacting protein 2	260							binding										TTCTCAGTCTGATAGTCATCT	0.483000													25	43					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116224332	116224332	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:116224332C>G	ENST00000374140.2	+	4	475	c.266C>G	c.(265-267)tCt>tGt	p.S89C	RGS3_ENST00000350696.5_Missense_Mutation_p.S89C	NM_001282923.1|NM_144488.4	NP_001269852.1|NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	89					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						AGTGTCCTCTCTACATCCTGT	0.547000													66	48					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118314780	118314780	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:118314780C>T	ENST00000369221.2	+	7	690	c.662C>T	c.(661-663)aCg>aTg	p.T221M		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	221					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity	p.T221K(2)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	GTAATTCACACGGATGGTGCC	0.483000													18	27					0	0	1	0	0
SPATA32	124783	broad.mit.edu	37	17	43332860	43332860	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:43332860G>C	ENST00000543122.1	-	6	1407	c.626C>G	c.(625-627)tCa>tGa	p.S209*	MAP3K14-AS1_ENST00000585346.1_RNA|MAP3K14-AS1_ENST00000592422.1_RNA|MAP3K14-AS1_ENST00000588698.1_RNA|MAP3K14-AS1_ENST00000590100.1_RNA|MAP3K14-AS1_ENST00000591263.1_RNA|MAP3K14-AS1_ENST00000588160.1_RNA|SPATA32_ENST00000331780.4_Nonsense_Mutation_p.S230*|MAP3K14-AS1_ENST00000588504.1_RNA					spermatogenesis associated 32																		CGGGAGATCTGAGGACAGGAG	0.612000													13	17					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178762916	178762916	+	Missense_Mutation	SNP	C	C	G	rs78426895		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:178762916C>G	ENST00000286063.6	-	4	1488	c.1171G>C	c.(1171-1173)Gag>Cag	p.E391Q	PDE11A_ENST00000449286.2_Missense_Mutation_p.E33Q|PDE11A_ENST00000358450.4_Missense_Mutation_p.E141Q|PDE11A_ENST00000409504.1_Missense_Mutation_p.E33Q|PDE11A_ENST00000497003.1_5'UTR	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A						platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TTAACCACCTCTAGCAAAGCC	0.343000									Primary Pigmented Nodular Adrenocortical Disease, Familial				17	32					0	0	1	0	0
EMID1	129080	broad.mit.edu	37	22	29627030	29627030	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:29627030G>C	ENST00000334018.6	+	6	675	c.487G>C	c.(487-489)Gag>Cag	p.E163Q	EMID1_ENST00000404820.3_Missense_Mutation_p.E163Q|EMID1_ENST00000484039.1_3'UTR|EMID1_ENST00000404755.3_Missense_Mutation_p.E163Q	NM_001267895.1|NM_133455.3	NP_001254824.1|NP_597712.2	Q96A84	EMID1_HUMAN	EMI domain containing 1	161						collagen				NS(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(2)|skin(3)	12						GACTGTCATAGAGCAGCCAGT	0.607000													12	53					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27538171	27538171	+	RNA	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:27538171C>G	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							GTTGAGGTCTCCTCCGTGGTT	0.522000													19	102					0	0	1	0	0
EPB41	2035	broad.mit.edu	37	1	29319902	29319902	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:29319902G>C	ENST00000343067.4	+	3	656	c.529G>C	c.(529-531)Gaa>Caa	p.E177Q	EPB41_ENST00000373798.1_Missense_Mutation_p.E177Q|EPB41_ENST00000373797.1_Missense_Mutation_p.E177Q|EPB41_ENST00000373800.3_5'UTR|EPB41_ENST00000349460.4_5'UTR|EPB41_ENST00000398863.2_Missense_Mutation_p.E177Q|EPB41_ENST00000356093.2_Missense_Mutation_p.E177Q|EPB41_ENST00000347529.3_Missense_Mutation_p.E177Q	NM_001166005.1	NP_001159477.1	P11171	41_HUMAN	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	177					blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|urinary_tract(1)	14		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		AGAAGGACTTGAAGAGTGCTC	0.378000													26	90					0	0	1	0	0
MSN	4478	broad.mit.edu	37	X	64959737	64959737	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:64959737C>T	ENST00000360270.5	+	13	1888	c.1716C>T	c.(1714-1716)gaC>gaT	p.D572D		NM_002444.2	NP_002435.1	P26038	MOES_HUMAN	moesin	572					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton	p.D572D(1)	MSN/ALK(6)	breast(4)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	43						AGCGCATTGACGAATTTGAGT	0.532000			T	ALK	ALCL								19	48					0	0	1	0	0
PPP2R5B	5526	broad.mit.edu	37	11	64698935	64698935	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:64698935G>C	ENST00000164133.2	+	9	1541	c.919G>C	c.(919-921)Gag>Cag	p.E307Q		NM_006244.3	NP_006235.1	Q15173	2A5B_HUMAN	protein phosphatase 2, regulatory subunit B', beta	307					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)	21						GCAGTTCCTGGAGAAGGATGC	0.597000													6	16					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50154448	50154448	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:50154448G>C	ENST00000360565.3	+	7	926	c.802G>C	c.(802-804)Gag>Cag	p.E268Q		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	268	Glu-rich.				mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		CCCCTCACCTgaggaggaaga	0.617000													29	12					0	0	1	0	0
EVI2B	2124	broad.mit.edu	37	17	29632166	29632166	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:29632166C>T	ENST00000330927.4	-	2	616	c.462G>A	c.(460-462)caG>caA	p.Q154Q	EVI2B_ENST00000577894.1_Silent_p.Q154Q|NF1_ENST00000356175.3_Intron|NF1_ENST00000358273.4_Intron|EVI2B_ENST00000544462.1_Silent_p.Q169Q	NM_006495.3	NP_006486.3	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B	154						cytoplasm|integral to plasma membrane		p.0?(8)|p.?(3)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	12		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		TAGAAGGGATCTGGACAGATG	0.393000													49	81					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99508187	99508187	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:99508187C>T	ENST00000376460.1	-	34	3876	c.3796G>A	c.(3796-3798)Gaa>Aaa	p.E1266K	DOCK9_ENST00000339416.2_Missense_Mutation_p.E1267K|DOCK9_ENST00000448493.2_Missense_Mutation_p.E1278K	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1267					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CTATTCCTTTCTGGAAGGCTG	0.398000													36	72					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15729015	15729015	+	RNA	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:15729015C>G	ENST00000441682.2	+	0	407							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						TTCTAGATCTCATCCCCAAAG	0.537000													22	20					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5406807	5406807	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:5406807G>A	ENST00000341928.2	-	16	2658	c.2318C>T	c.(2317-2319)gCc>gTc	p.A773V	EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000542146.1_Missense_Mutation_p.A45V|EPB41L3_ENST00000540638.2_Missense_Mutation_p.A592V|EPB41L3_ENST00000427684.2_Missense_Mutation_p.A45V|EPB41L3_ENST00000544123.1_Missense_Mutation_p.A604V|EPB41L3_ENST00000342933.3_Missense_Mutation_p.A773V|EPB41L3_ENST00000400111.3_Missense_Mutation_p.A592V	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	773	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						GATCATGGGGGCATCCTCCTG	0.537000													22	51					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135211731	135211731	+	Missense_Mutation	SNP	G	G	C	rs141974509		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:135211731G>C	ENST00000372169.2	-	6	852	c.670C>G	c.(670-672)Ctg>Gtg	p.L224V	SETX_ENST00000224140.5_Missense_Mutation_p.L224V|SETX_ENST00000393220.1_Missense_Mutation_p.L224V			Q7Z333	SETX_HUMAN	senataxin	224					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TGTGAGGGCAGAAGAATCAGT	0.348000													18	22					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96137275	96137275	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:96137275C>T	ENST00000506749.1	-	11	2138	c.1790G>A	c.(1789-1791)aGg>aAg	p.R597K	UNC5C_ENST00000453304.1_Splice_Site_p.R578K			O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	578	ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GCATATTTACCTCATAGTTTC	0.413000													14	16					0	0	1	0	0
TSSK3	81629	broad.mit.edu	37	1	32829401	32829401	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:32829401G>C	ENST00000373534.3	+	2	856	c.351G>C	c.(349-351)caG>caC	p.Q117H	FAM229A_ENST00000415596.1_Intron	NM_052841.3	NP_443073.1	Q96PN8	TSSK3_HUMAN	testis-specific serine kinase 3	117	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|large_intestine(6)|lung(5)|skin(2)|stomach(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.17)|Breast(348;0.212)				TCTTCCGTCAGATGGTTGAGG	0.607000													23	46					0	0	1	0	0
PWWP2A	114825	broad.mit.edu	37	5	159507713	159507713	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:159507713C>T	ENST00000456329.3	-	3	1648	c.1614G>A	c.(1612-1614)ctG>ctA	p.L538L	PWWP2A_ENST00000523662.1_Intron	NM_052927.2	NP_443159.1	Q96N64	PWP2A_HUMAN	PWWP domain containing 2A	0										kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGTGGTCTGTCAGACACTGTA	0.453000													9	3					0	0	1	0	0
CEP85	64793	broad.mit.edu	37	1	26584195	26584195	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:26584195G>A	ENST00000252992.4	+	5	1142	c.1011G>A	c.(1009-1011)ctG>ctA	p.L337L	CEP85_ENST00000451429.2_Silent_p.L286L	NM_001281517.1|NM_022778.2	NP_001268446.1|NP_073615.2	Q6P2H3	CEP85_HUMAN	centrosomal protein 85kDa	337						centrosome|nucleolus|spindle pole				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(11)|skin(2)	25						AACACCTTCTGAAGGAAAAAG	0.502000													24	120					0	0	1	0	0
LIN52	91750	broad.mit.edu	37	14	74567871	74567871	+	Silent	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:74567871C>A	ENST00000555028.1	+	5	392	c.225C>A	c.(223-225)ctC>ctA	p.L75L	LIN52_ENST00000554076.1_3'UTR	NM_001024674.2	NP_001019845.1	Q52LA3	LIN52_HUMAN	lin-52 homolog (C. elegans)	75										breast(1)|endometrium(2)|lung(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.00471)		TGGGGAGTCTCACCACGGCTA	0.463000													28	59					4.02929e-09	4.1658e-09	1	1	0
ID1	3397	broad.mit.edu	37	20	30193278	30193278	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:30193278G>A	ENST00000376105.3	+	1	187	c.88G>A	c.(88-90)Gag>Aag	p.E30K	ID1_ENST00000376112.3_Missense_Mutation_p.E30K	NM_181353.2	NP_851998.1	P41134	ID1_HUMAN	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	30					angiogenesis|blood vessel endothelial cell migration|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by transcription factor localization|transforming growth factor beta receptor signaling pathway	cytoplasm	protein binding			endometrium(2)|ovary(1)|pancreas(1)	4	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.99e-05)|all cancers(5;0.000169)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			CGGTGCGGGCGAGGTGGTGCG	0.721000													10	9					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188211069	188211069	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:188211069A>G	ENST00000409998.1	-	16	2009	c.1228T>C	c.(1228-1230)Ttt>Ctt	p.F410L	CALCRL_ENST00000410068.1_Missense_Mutation_p.F410L|AC007319.1_ENST00000412276.1_RNA|AC007319.1_ENST00000453517.1_RNA|CALCRL_ENST00000392370.3_Missense_Mutation_p.F410L			Q16602	CALRL_HUMAN	calcitonin receptor-like	410						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			GAGTTGGAAAAGCTGTTTCCA	0.383000													18	50					0	0	1	0	0
RCN2	5955	broad.mit.edu	37	15	77228016	77228016	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:77228016G>C	ENST00000394885.3	+	3	623	c.400G>C	c.(400-402)Gat>Cat	p.D134H	RCN2_ENST00000394883.3_Intron|RCN2_ENST00000320963.5_Missense_Mutation_p.D134H	NM_002902.2	NP_002893.1	Q14257	RCN2_HUMAN	reticulocalbin 2, EF-hand calcium binding domain	134						endoplasmic reticulum lumen	calcium ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(1)	7						GATTGACTTTGATGAGAACAC	0.378000													25	53					0	0	1	0	0
PCMT1	5110	broad.mit.edu	37	6	150094297	150094297	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:150094297C>G	ENST00000464889.1	+	3	642	c.358C>G	c.(358-360)Cca>Gca	p.P120A	PCMT1_ENST00000367384.2_Missense_Mutation_p.P120A|PCMT1_ENST00000544496.1_Missense_Mutation_p.P27A|PCMT1_ENST00000367380.5_Missense_Mutation_p.P62A|PCMT1_ENST00000367378.1_Missense_Mutation_p.P120A					protein-L-isoaspartate (D-aspartate) O-methyltransferase									p.P62T(1)		kidney(1)|large_intestine(2)|lung(4)|ovary(1)	8		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.221)	OV - Ovarian serous cystadenocarcinoma(155;5.63e-13)|GBM - Glioblastoma multiforme(68;0.207)		AATCAGTGCTCCACACATGGT	0.303000													11	39					0	0	1	0	0
VCPIP1	80124	broad.mit.edu	37	8	67577747	67577747	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:67577747C>G	ENST00000310421.4	-	1	1705	c.1447G>C	c.(1447-1449)Gag>Cag	p.E483Q		NM_025054.4	NP_079330.2	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex interacting protein 1	483					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			breast(7)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(6)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			GCCAACCACTCTGGAGGAACA	0.448000													48	102					0	0	1	0	0
R3HDM1	23518	broad.mit.edu	37	2	136362421	136362421	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:136362421G>A	ENST00000264160.4	+	3	376	c.6G>A	c.(4-6)agG>agA	p.R2R	R3HDM1_ENST00000409606.1_Silent_p.R2R|R3HDM1_ENST00000409478.1_Silent_p.R2R|R3HDM1_ENST00000410054.1_Intron|R3HDM1_ENST00000329971.3_Silent_p.R2R	NM_001282798.1|NM_015361.2	NP_001269727.1|NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	2							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		TTCTAATGAGGATGTCTGATA	0.323000													17	41					0	0	1	0	0
GCM2	9247	broad.mit.edu	37	6	10874786	10874786	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:10874786C>G	ENST00000379491.4	-	5	1110	c.963G>C	c.(961-963)gaG>gaC	p.E321D	SYCP2L_ENST00000543878.1_Intron|RP11-637O19.3_ENST00000480294.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	321					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				CAAAGCTTCTCTCATAGCTGC	0.453000													19	113					0	0	1	0	0
ANKS1A	23294	broad.mit.edu	37	6	34957043	34957043	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:34957043G>A	ENST00000360359.3	+	9	1390	c.1252G>A	c.(1252-1254)Gag>Aag	p.E418K	ANKS1A_ENST00000535627.1_Intron	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	418						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						GCCCGATGAAGAGGAAGAAGA	0.398000													35	90					0	0	1	0	0
PRKAR2A	5576	broad.mit.edu	37	3	48820492	48820492	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:48820492C>G	ENST00000265563.8	-	5	718	c.469G>C	c.(469-471)Gaa>Caa	p.E157Q	PRKAR2A_ENST00000296446.8_Missense_Mutation_p.E157Q|PRKAR2A_ENST00000454963.1_Missense_Mutation_p.E157Q	NM_004157.2	NP_004148.1	P13861	KAP2_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, alpha	157					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity		SLC26A6/PRKAR2A(2)	breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		ACTATCCTTTCAAACATGGCA	0.393000													9	61					0	0	1	0	0
RNASE8	122665	broad.mit.edu	37	14	21526415	21526415	+	Missense_Mutation	SNP	G	G	C	rs140610133	by1000genomes	TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:21526415G>C	ENST00000308227.2	+	1	435	c.364G>C	c.(364-366)Gag>Cag	p.E122Q	NDRG2_ENST00000403829.3_Intron	NM_138331.1	NP_612204.1	Q8TDE3	RNAS8_HUMAN	ribonuclease, RNase A family, 8	122						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;3.42e-11)|Epithelial(56;5.57e-09)|all cancers(55;2.36e-08)	GBM - Glioblastoma multiforme(265;0.0188)		CAGGTACAAAGAGAAGCACCT	0.527000													30	77					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													5	13					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41751506	41751506	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:41751506G>C	ENST00000352645.4	+	18	2325	c.2068G>C	c.(2068-2070)Gac>Cac	p.D690H	ZC3H7B_ENST00000351589.4_Missense_Mutation_p.D690H	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	706					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						CAGCACCTTTGACCTGCAGAT	0.622000													8	35					0	0	1	0	0
FBXW7	55294	broad.mit.edu	37	4	153250865	153250865	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:153250865C>G	ENST00000281708.4	-	8	2424	c.1195G>C	c.(1195-1197)Gat>Cat	p.D399H	FBXW7_ENST00000393956.3_Missense_Mutation_p.D223H|FBXW7_ENST00000603841.1_Missense_Mutation_p.D399H|FBXW7_ENST00000263981.5_Missense_Mutation_p.D319H|FBXW7_ENST00000603548.1_Missense_Mutation_p.D399H|FBXW7_ENST00000296555.5_Missense_Mutation_p.D281H	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	399					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GTGTTGTCATCAGAACCACTA	0.358000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								27	37					0	0	1	0	0
KAL1	3730	broad.mit.edu	37	X	8553350	8553350	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:8553350G>A	ENST00000262648.3	-	6	963	c.814C>T	c.(814-816)Cga>Tga	p.R272*		NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	272	Fibronectin type-III 1.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						GTGAAGCCTCGAGTTCCATGC	0.517000													18	33					0	0	1	0	0
KIRREL	55243	broad.mit.edu	37	1	158061331	158061331	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:158061331C>T	ENST00000368172.1	+	7	910	c.898C>T	c.(898-900)Cag>Tag	p.Q300*	KIRREL_ENST00000416935.2_Nonsense_Mutation_p.Q386*|KIRREL_ENST00000359209.6_Nonsense_Mutation_p.Q486*|KIRREL_ENST00000392272.2_Nonsense_Mutation_p.Q383*|KIRREL_ENST00000368173.3_Nonsense_Mutation_p.Q502*|KIRREL_ENST00000360089.4_Nonsense_Mutation_p.Q322*			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	486						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					AGCCATCATCCAGCTGGAAGA	0.587000													21	50					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95523740	95523740	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:95523740C>G	ENST00000297591.5	-	13	3138	c.3063G>C	c.(3061-3063)ctG>ctC	p.L1021L	KIAA1429_ENST00000421249.2_Silent_p.L1021L|KIAA1429_ENST00000523405.1_5'UTR|KIAA1429_ENST00000437199.1_Silent_p.L1021L	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1021					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ATCCACCTCTCAGGAGTTCCG	0.463000													23	40					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880982	142880982	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:142880982G>C	ENST00000446620.1	+	1	471	c.471G>C	c.(469-471)ttG>ttC	p.L157F		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	157					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					TTACTGGATTGATACCCTGGC	0.453000													27	61					0	0	1	0	0
MTA2	9219	broad.mit.edu	37	11	62363235	62363235	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:62363235G>A	ENST00000278823.2	-	13	1632	c.1243C>T	c.(1243-1245)Cgg>Tgg	p.R415W	MTA2_ENST00000524902.1_Missense_Mutation_p.R242W|MTA2_ENST00000527204.1_Missense_Mutation_p.R242W	NM_004739.3	NP_004730.2	O94776	MTA2_HUMAN	metastasis associated 1 family, member 2	415					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	26						GTGGTGCCCCGAGTGGCCCCC	0.527000													11	82					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109735274	109735274	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:109735274C>G	ENST00000369939.3	+	14	1908	c.1725C>G	c.(1723-1725)atC>atG	p.I575M	KIAA1324_ENST00000369938.1_3'UTR|KIAA1324_ENST00000529753.1_Missense_Mutation_p.I488M	NM_020775.4	NP_065826	Q6UXG2	K1324_HUMAN	KIAA1324	575					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		TCTACTCCATCAATGTCACCA	0.532000													58	118					0	0	1	0	0
BROX	148362	broad.mit.edu	37	1	222892290	222892290	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:222892290G>A	ENST00000340934.5	+	3	531	c.125G>A	c.(124-126)cGa>cAa	p.R42Q	BROX_ENST00000537020.1_Missense_Mutation_p.R42Q|BROX_ENST00000539697.1_Missense_Mutation_p.R42Q	NM_144695.2	NP_653296.2	Q5VW32	BROX_HUMAN	BRO1 domain and CAAX motif containing	42						membrane				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|stomach(1)	14						TCCAGGGCACGACTCCTTGAA	0.363000													62	107					0	0	1	0	0
CDKN1A	1026	broad.mit.edu	37	6	36651968	36651968	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:36651968G>A	ENST00000405375.1	+	2	325	c.90G>A	c.(88-90)ctG>ctA	p.L30L	CDKN1A_ENST00000448526.2_Silent_p.L64L|CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000373711.2_Silent_p.L30L|CDKN1A_ENST00000244741.5_Silent_p.L30L	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	30					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						GCGAGCAGCTGAGCCGCGACT	0.647000													11	24					0	0	1	0	0
NR1D2	9975	broad.mit.edu	37	3	24018854	24018854	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:24018854C>T	ENST00000312521.4	+	8	2003	c.1684C>T	c.(1684-1686)Cga>Tga	p.R562*	NR1D2_ENST00000492552.1_3'UTR	NM_001145425.1|NM_005126.4	NP_001138897.1|NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	562					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			NS(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	22						GCCAGATCTTCGATCTTTAAA	0.378000													29	77					0	0	1	0	0
DDX43	55510	broad.mit.edu	37	6	74124403	74124403	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:74124403G>C	ENST00000370336.4	+	14	1897	c.1739G>C	c.(1738-1740)aGa>aCa	p.R580T	MB21D1_ENST00000370318.1_Intron	NM_018665.2	NP_061135.2	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	580	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						CGCACGGGAAGAGCAGGGTAA	0.418000													20	44					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51315045	51315045	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:51315045G>A	ENST00000266037.9	+	26	2706	c.2683G>A	c.(2683-2685)Gat>Aat	p.D895N		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	895						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CCAGGAGGCAGATGTCATGGA	0.557000													12	11					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7792599	7792599	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:7792599G>C	ENST00000303635.7	+	12	3213	c.3006G>C	c.(3004-3006)gcG>gcC	p.A1002A	CAMTA1_ENST00000439411.2_Silent_p.A1002A	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1002					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		ACAAACAGGCGAGCGGAGGCG	0.627000			T	WWTR1	epitheliod hemangioendothelioma								16	26					0	0	1	0	0
PMS2P3	5387	broad.mit.edu	37	7	75145511	75145511	+	RNA	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:75145511G>A	ENST00000418756.1	-	0	653					NR_028059.1															lung(1)	1						CCTCCTGGGTGAAATCCACAG	0.473000													11	63					0	0	1	0	0
CYYR1	116159	broad.mit.edu	37	21	27945196	27945196	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr21:27945196C>T	ENST00000299340.4	-	1	407	c.64G>A	c.(64-66)Gtc>Atc	p.V22I	CYYR1_ENST00000435845.2_Missense_Mutation_p.V130I|CYYR1_ENST00000400043.3_Missense_Mutation_p.V22I	NM_052954.2	NP_443186.1	Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	22						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						CCTGCGTAGACAAAGAGCAGG	0.662000													13	40					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111382137	111382137	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:111382137C>G	ENST00000428084.1	-	45	5001	c.4729G>C	c.(4729-4731)Gat>Cat	p.D1577H	DOCK4_ENST00000494651.2_Missense_Mutation_p.D451H|DOCK4_ENST00000437633.1_Missense_Mutation_p.D1568H			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1568	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				GGTCTCATATCTTGAGGTACA	0.433000													24	50					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162306914	162306914	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:162306914C>A	ENST00000306100.5	-	16	2965	c.2529G>T	c.(2527-2529)tgG>tgT	p.W843C	FSTL5_ENST00000427802.2_Missense_Mutation_p.W833C|FSTL5_ENST00000379164.4_Missense_Mutation_p.W842C|RP11-234O6.2_ENST00000508189.1_RNA|FSTL5_ENST00000536695.1_Missense_Mutation_p.W842C	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	843						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CATCTCCAACCCAAATGACTG	0.348000													18	50					9.16793e-09	9.44944e-09	1	1	0
HIVEP3	59269	broad.mit.edu	37	1	41976601	41976601	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:41976601C>T	ENST00000372584.1	-	8	7753	c.6739G>A	c.(6739-6741)Gag>Aag	p.E2247K	HIVEP3_ENST00000429157.2_Missense_Mutation_p.E2247K|HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000372583.1_Missense_Mutation_p.E2248K|HIVEP3_ENST00000247584.5_Missense_Mutation_p.E2248K	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	2248					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GACGAGCTCTCAGTGGGACTC	0.682000													26	34					0	0	1	0	0
PAX2	5076	broad.mit.edu	37	10	102568920	102568920	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:102568920G>C	ENST00000370296.2	+	8	1465	c.915G>C	c.(913-915)tcG>tcC	p.S305S	PAX2_ENST00000428433.1_Silent_p.S305S|PAX2_ENST00000355243.3_Silent_p.S282S|PAX2_ENST00000361791.3_Silent_p.S282S|PAX2_ENST00000556085.1_Silent_p.S281S			Q02962	PAX2_HUMAN	paired box 2	305					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		AAGTCAAGTCGAGTCTATCTG	0.577000													26	40					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189871699	189871699	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:189871699G>A	ENST00000304636.3	+	44	3408	c.3238G>A	c.(3238-3240)Ggt>Agt	p.G1080S	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1080	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CGGTCCTGCTGGTTCCCGAGG	0.388000													6	35					0	0	1	0	0
UBQLN4	56893	broad.mit.edu	37	1	156020243	156020243	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:156020243C>G	ENST00000368309.3	-	4	672	c.580G>C	c.(580-582)Gag>Cag	p.E194Q	UBQLN4_ENST00000472638.1_Intron	NM_020131.3	NP_064516.2	Q9NRR5	UBQL4_HUMAN	ubiquilin 4	194						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)	16	Hepatocellular(266;0.133)|all_neural(408;0.195)					GACAGCATCTCAGGATTGGAC	0.572000													51	103					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152426865	152426865	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:152426865G>A	ENST00000427231.2	-	109	17362	c.17160C>T	c.(17158-17160)taC>taT	p.Y5720Y	NEB_ENST00000172853.10_Silent_p.Y4019Y|NEB_ENST00000603639.1_Silent_p.Y5720Y|NEB_ENST00000397345.3_Silent_p.Y5720Y|NEB_ENST00000604864.1_Silent_p.Y5720Y|NEB_ENST00000409198.1_Silent_p.Y4019Y	NM_001164507.1|NM_001271208.1	NP_001157979|NP_001258137.1	P20929	NEBU_HUMAN	nebulin	5736					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGGTGCCCACGTAGTGTCCCT	0.512000													7	25					0	0	1	0	0
CALR	811	broad.mit.edu	37	19	13051415	13051415	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:13051415G>A	ENST00000316448.5	+	6	836	c.763G>A	c.(763-765)Gaa>Aaa	p.E255K		NM_004343.3	NP_004334.1	P27797	CALR_HUMAN	calreticulin	255	4 X approximate repeats.|P-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(1)	10					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGACTGGGATGAAGAGATGGA	0.582000													36	13					0	0	1	0	0
AKT2	208	broad.mit.edu	37	19	40741238	40741238	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:40741238C>T	ENST00000392038.2	-	12	1493	c.1195G>A	c.(1195-1197)Gat>Aat	p.D399N	AKT2_ENST00000424901.1_Missense_Mutation_p.D399N|AKT2_ENST00000311278.6_Missense_Mutation_p.D356N|AKT2_ENST00000579047.1_Missense_Mutation_p.D337N	NM_001243027.1|NM_001243028.1|NM_001626.4	NP_001229956.1|NP_001229957.1|NP_001617.1	P31751	AKT2_HUMAN	v-akt murine thymoma viral oncogene homolog 2	399	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(3)|large_intestine(9)|lung(10)|prostate(2)|skin(1)	27			Lung(22;0.000499)			TCCTTGGCATCGCTGGGCCCC	0.657000			A		"""ovarian, pancreatic """								16	78					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123333068	123333068	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:123333068C>T	ENST00000360772.3	-	34	5854	c.5476G>A	c.(5476-5478)Gat>Aat	p.D1826N	MYLK_ENST00000346322.5_Missense_Mutation_p.D1808N|MYLK_ENST00000354792.5_Missense_Mutation_p.D677N|MYLK_ENST00000583087.1_Missense_Mutation_p.D117N|MYLK_ENST00000418370.2_Missense_Mutation_p.D117N|MYLK_ENST00000360304.3_Missense_Mutation_p.D1877N|MYLK_ENST00000359169.1_Missense_Mutation_p.D1826N|MYLK_ENST00000475616.1_Missense_Mutation_p.D1877N|MYLK-AS1_ENST00000485162.1_RNA|MYLK_ENST00000578202.1_Missense_Mutation_p.D116N|MYLK-AS1_ENST00000463408.1_RNA|MYLK-AS1_ENST00000470449.1_RNA			Q15746	MYLK_HUMAN	myosin light chain kinase	1877	Ig-like C2-type 9.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TACTTGGCATCGTCATCCCCG	0.512000													33	150					0	0	1	0	0
AGR3	155465	broad.mit.edu	37	7	16899228	16899228	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:16899228C>T	ENST00000310398.2	-	8	549	c.479G>A	c.(478-480)aGa>aAa	p.R160K		NM_176813.3	NP_789783.1	Q8TD06	AGR3_HUMAN	anterior gradient 3	160						extracellular region				central_nervous_system(1)|kidney(8)|lung(2)|skin(1)|stomach(1)	13	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		CTGAATAAGTCTTAATGCTTT	0.289000													4	20					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7173213	7173213	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:7173213C>T	ENST00000406697.1	+	10	1438	c.810C>T	c.(808-810)atC>atT	p.I270I	C1S_ENST00000328916.3_Silent_p.I270I|C1S_ENST00000360817.5_Silent_p.I270I|C1S_ENST00000402681.3_Silent_p.I103I			P09871	C1S_HUMAN	complement component 1, s subcomponent	270	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	CTCTTGATATCATCTTCCAAA	0.428000													41	57					0	0	1	0	0
YAE1D1	57002	broad.mit.edu	37	7	39612071	39612071	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:39612071G>A	ENST00000223273.2	+	3	490	c.447G>A	c.(445-447)gaG>gaA	p.E149E	YAE1D1_ENST00000432096.2_Intron|YAE1D1_ENST00000448268.1_3'UTR	NM_020192.3	NP_064577.1	Q9NRH1	CG036_HUMAN	Yae1 domain containing 1	149																	TTCCAGCTGAGAAAAAGATTG	0.378000													37	61					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5540319	5540319	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:5540319G>A	ENST00000382368.3	-	3	1704	c.1581C>T	c.(1579-1581)atC>atT	p.I527I	FBXL18_ENST00000453700.3_Silent_p.I527I	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	527									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		CCAGCTGGCCGATGGCGGCCA	0.692000													4	4					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167134678	167134678	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:167134678C>G	ENST00000375387.4	-	15	2832	c.2492G>C	c.(2491-2493)gGa>gCa	p.G831A	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.G819A|SCN9A_ENST00000303354.6_Missense_Mutation_p.G831A|SCN9A_ENST00000409435.1_Missense_Mutation_p.G830A			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	830						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	AACTGACAATCCTTCCACATC	0.353000													21	46					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54593189	54593189	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:54593189C>G	ENST00000251636.5	-	3	447	c.299G>C	c.(298-300)gGa>gCa	p.G100A		NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	100							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				ATTGATCACTCCAATAATTCT	0.294000													11	14					0	0	1	0	0
GP6	51206	broad.mit.edu	37	19	55527085	55527085	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:55527085G>C	ENST00000310373.3	-	7	768	c.741C>G	c.(739-741)atC>atG	p.I247M	GP6_ENST00000333884.2_Missense_Mutation_p.I229M|CTC-550B14.7_ENST00000586845.1_RNA|CTC-550B14.7_ENST00000593060.1_RNA|GP6_ENST00000417454.1_Missense_Mutation_p.I247M	NM_001083899.1	NP_001077368	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet)	247					enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		GACTGGCGGTGATACTCCTAG	0.517000													3	12					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37649014	37649014	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:37649014C>T	ENST00000447079.4	+	4	2152	c.2119C>T	c.(2119-2121)Cct>Tct	p.P707S	CDK12_ENST00000430627.2_Missense_Mutation_p.P707S	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	707					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						AATTTGTTGTCCTCGTTATGG	0.438000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			8	37					0	0	1	0	0
VAT1	10493	broad.mit.edu	37	17	41168485	41168485	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:41168485C>T	ENST00000355653.3	-	5	1032	c.937G>A	c.(937-939)Gct>Act	p.A313T	VAT1_ENST00000420567.3_Missense_Mutation_p.A179T|VAT1_ENST00000587173.1_Missense_Mutation_p.A245T	NM_006373.3	NP_006364.2	Q99536	VAT1_HUMAN	vesicle amine transport 1	313						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	9		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		AGCTGCAGAGCTGTCACGCTG	0.622000													13	23					0	0	1	0	0
NUP43	348995	broad.mit.edu	37	6	150057633	150057633	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:150057633G>C	ENST00000340413.2	-	6	840	c.764C>G	c.(763-765)tCt>tGt	p.S255C	NUP43_ENST00000460354.2_Missense_Mutation_p.S255C|NUP43_ENST00000367403.3_3'UTR|NUP43_ENST00000367404.4_Intron	NM_198887.1	NP_942590.1	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	255					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			breast(1)|large_intestine(2)|lung(8)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		CTTCAGCAGAGATACAGGCAT	0.388000													12	21					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35454833	35454833	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:35454833G>A	ENST00000353139.5	-	53	7133	c.6652C>T	c.(6652-6654)Cag>Tag	p.Q2218*	ACACA_ENST00000335166.5_Nonsense_Mutation_p.Q2103*|ACACA_ENST00000394406.2_Nonsense_Mutation_p.Q2181*|ACACA_ENST00000360679.3_Nonsense_Mutation_p.Q2123*|ACACA_ENST00000361253.5_Nonsense_Mutation_p.Q307*	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	2181					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ACGGCTACCTGATGGTAAATG	0.502000													49	78					0	0	1	0	0
FAM161B	145483	broad.mit.edu	37	14	74416800	74416800	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:74416800G>A	ENST00000286544.3	-	1	317	c.119C>T	c.(118-120)cCg>cTg	p.P40L	COQ6_ENST00000394026.4_Missense_Mutation_p.R2Q|FAM161B_ENST00000534936.1_5'UTR|COQ6_ENST00000238709.4_5'UTR	NM_152445.2	NP_689658.2			family with sequence similarity 161, member B											breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)	21						AGAGCTATGCGGGGCCAGGGT	0.642000													15	14					0	0	1	0	0
SLC2A11	66035	broad.mit.edu	37	22	24226015	24226015	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:24226015G>C	ENST00000345044.6	+	9	1309	c.1041G>C	c.(1039-1041)ctG>ctC	p.L347L	SLC2A11_ENST00000398356.2_Silent_p.L354L|SLC2A11_ENST00000316185.8_Silent_p.L350L|AP000350.10_ENST00000433835.3_Intron			Q9BYW1	GTR11_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 11	347						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						GGTACAGCCTGATGACCTGCT	0.637000													9	47					0	0	1	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117417611	117417611	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:117417611C>G	ENST00000160373.3	-	8	2823	c.2732G>C	c.(2731-2733)aGa>aCa	p.R911T		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	911										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CCAGCCTTCTCTGTTGGCGTG	0.502000													19	48					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80718550	80718550	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:80718550C>T	ENST00000570137.2	-	2	656	c.501G>A	c.(499-501)gaG>gaA	p.E167E	CDYL2_ENST00000566173.1_Silent_p.E167E|CDYL2_ENST00000563890.1_Silent_p.E167E|CDYL2_ENST00000562753.1_5'UTR|CDYL2_ENST00000562812.1_Silent_p.E167E	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2							nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						CAAAGTGCCTCTCATCCTTCT	0.502000													11	129					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965090	88965090	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:88965090G>A	ENST00000333190.4	+	4	3403	c.2794G>A	c.(2794-2796)Gta>Ata	p.V932I		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	932						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TTTAGAAAGAGTACAAGCCAA	0.413000										HNSCC(36;0.09)			33	93					0	0	1	0	0
LRP8	7804	broad.mit.edu	37	1	53724124	53724124	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:53724124C>G	ENST00000306052.6	-	14	2177	c.2076G>C	c.(2074-2076)ctG>ctC	p.L692L	LRP8_ENST00000347547.2_Silent_p.L522L|LRP8_ENST00000354412.3_Silent_p.L563L|LRP8_ENST00000465675.1_Silent_p.L245L|LRP8_ENST00000371454.2_Silent_p.L692L|LRP8_ENST00000460214.1_5'UTR	NM_004631.4	NP_004622.2	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	692					cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(1)	21						GCTGGACACTCAGCTCACAGG	0.562000													17	37					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128522769	128522769	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:128522769G>A	ENST00000322313.4	-	5	611	c.453C>T	c.(451-453)ttC>ttT	p.F151F	WDR33_ENST00000409658.3_Silent_p.F151F|WDR33_ENST00000393006.1_Silent_p.F151F	NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	151					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TTTCAAAATTGAAAGTGAGTC	0.398000													17	38					0	0	1	0	0
CALR	811	broad.mit.edu	37	19	13051418	13051418	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:13051418G>A	ENST00000316448.5	+	6	839	c.766G>A	c.(766-768)Gag>Aag	p.E256K		NM_004343.3	NP_004334.1	P27797	CALR_HUMAN	calreticulin	256	P-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(1)	10					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGGGATGAAGAGATGGACGG	0.582000													36	13					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125437065	125437065	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:125437065G>A	ENST00000308736.2	-	21	2845	c.2747C>T	c.(2746-2748)cCg>cTg	p.P916L	DHX37_ENST00000544745.1_Missense_Mutation_p.P703L	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	916							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CTCGGTGGGCGGCTGCATCTT	0.657000													18	46					0	0	1	0	0
CXCR4	7852	broad.mit.edu	37	2	136872570	136872570	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:136872570T>C	ENST00000409817.1	-	1	1243	c.940A>G	c.(940-942)Aaa>Gaa	p.K314E	CXCR4_ENST00000241393.3_Missense_Mutation_p.K310E|CXCR4_ENST00000466288.1_5'UTR	NM_001008540.1	NP_001008540.1	P61073	CXCR4_HUMAN	chemokine (C-X-C motif) receptor 4	310					activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)	GCAGAGGTTTTAAATTTGGCT	0.507000													16	85					0	0	1	0	0
GPRASP2	114928	broad.mit.edu	37	X	101970855	101970855	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:101970855G>A	ENST00000543253.1	+	5	1977	c.1058G>A	c.(1057-1059)aGa>aAa	p.R353K	GPRASP2_ENST00000332262.5_Missense_Mutation_p.R353K|GPRASP2_ENST00000535209.1_Missense_Mutation_p.R353K	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						TTCAGGCACAGAGACAAAGAA	0.428000													13	55					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60033200	60033200	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:60033200C>T	ENST00000397786.2	-	25	5700		c.e25-1			NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						CAGCTCCAATCTGTGGGTATC	0.328000													13	33					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34148133	34148133	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:34148133G>A	ENST00000346193.3	-	1	2314	c.2263C>T	c.(2263-2265)Caa>Taa	p.Q755*		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	755										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						AACAGCCTTTGAATGATGCCA	0.408000													28	90					0	0	1	0	0
FAM217A	222826	broad.mit.edu	37	6	4069972	4069972	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:4069972C>G	ENST00000274673.3	-	7	888	c.485G>C	c.(484-486)aGa>aCa	p.R162T	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	162																	AATCTCATTTCTGTTCTTAAA	0.398000													20	39					0	0	1	0	0
TRIL	9865	broad.mit.edu	37	7	28996295	28996295	+	RNA	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:28996295G>C	ENST00000322982.3	-	0	1639							Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										CCTGCTGCTGGAGCTGCGGCT	0.731000													14	31					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69833131	69833131	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:69833131G>C	ENST00000359154.2	+	4	374	c.273G>C	c.(271-273)ttG>ttC	p.L91F	WWP2_ENST00000448661.1_Missense_Mutation_p.L91F|WWP2_ENST00000356003.2_Missense_Mutation_p.L91F|WWP2_ENST00000569174.1_Missense_Mutation_p.L91F|WWP2_ENST00000544162.1_3'UTR	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	91	C2.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCCATACCTTGAGAAATGAAC	0.453000											OREG0023909	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	113					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4512190	4512190	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:4512190C>T	ENST00000301286.3	-	3	1739	c.1740G>A	c.(1738-1740)ctG>ctA	p.L580L		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	580	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						TGGTGCCGGTCAGCACGGTCT	0.582000													164	118					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47939152	47939152	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:47939152G>C	ENST00000402813.3	-	10	1708	c.1566C>G	c.(1564-1566)gtC>gtG	p.V522V	CNGA1_ENST00000544810.1_Silent_p.V453V|CNGA1_ENST00000358519.4_Silent_p.V453V|CNGA1_ENST00000514170.1_Silent_p.V453V|CNGA1_ENST00000420489.2_Silent_p.V453V			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	453					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						GATACTTTAAGACTTCTTTCT	0.348000													19	79					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	430940	430940	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:430940G>C	ENST00000256509.2	+	20	2895	c.2253G>C	c.(2251-2253)ttG>ttC	p.L751F	CHL1_ENST00000397491.2_Missense_Mutation_p.L735F	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	735	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		tttagcctttgaaatccatgg	0.468000													3	13					0	0	1	0	0
SERPINC1	462	broad.mit.edu	37	1	173878966	173878966	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:173878966G>A	ENST00000367698.3	-	5	995	c.877C>T	c.(877-879)Cgg>Tgg	p.R293W		NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	293			Missing (in AT3D; type-I).		blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	GCCACGCGCCGATAACGGAAC	0.522000													42	62					0	0	1	0	0
CALB2	794	broad.mit.edu	37	16	71411635	71411635	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:71411635C>T	ENST00000302628.4	+	4	404	c.327C>T	c.(325-327)agC>agT	p.S109S	CALB2_ENST00000349553.5_Silent_p.S109S	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	109	EF-hand 3.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				TGGGCTCCAGCGCCGAGTTTA	0.577000													11	68					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551800	248551800	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:248551800G>C	ENST00000355728.2	+	1	891	c.891G>C	c.(889-891)gtG>gtC	p.V297V		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACAGGGATGTGATGGGTGCCT	0.458000													27	31					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25361009	25361009	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:25361009G>C	ENST00000330560.3	+	14	2269	c.1792G>C	c.(1792-1794)Gaa>Caa	p.E598Q	CDCA2_ENST00000521098.2_3'UTR|CDCA2_ENST00000380665.3_Missense_Mutation_p.E583Q	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	598					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		CGAGCTGCCTGAAGTCCCTGA	0.443000													10	75					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79385976	79385976	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:79385976G>A	ENST00000370742.3	-	10	1416	c.1353C>T	c.(1351-1353)ttC>ttT	p.F451F		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	451					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TTTCACTGAAGAACCAGAAGG	0.323000													27	65					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31295173	31295173	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:31295173C>G	ENST00000542188.1	-	27	4094	c.3781G>C	c.(3781-3783)Gaa>Caa	p.E1261Q	TRPM1_ENST00000397795.2_Missense_Mutation_p.E1222Q|TRPM1_ENST00000256552.6_Missense_Mutation_p.E1244Q|RP11-348B17.1_ENST00000561299.1_RNA	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1222					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity	p.E1222K(1)		NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTAGATAATTCTTCTAGCTGA	0.433000													33	42					0	0	1	0	0
FSTL1	11167	broad.mit.edu	37	3	120121766	120121766	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:120121766C>G	ENST00000295633.3	-	9	1051		c.e9-1		FSTL1_ENST00000424703.2_Splice_Site	NM_007085.4	NP_009016.1	Q12841	FSTL1_HUMAN	follistatin-like 1						BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(1)	20				GBM - Glioblastoma multiforme(114;0.189)		AGGGCACACTCTGTTGGGCCA	0.527000													21	42					0	0	1	0	0
TMTC3	160418	broad.mit.edu	37	12	88560325	88560325	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:88560325G>C	ENST00000266712.6	+	7	1236	c.1016G>C	c.(1015-1017)aGa>aCa	p.R339T		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	339						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						TTCAGTATCAGATACTCTGGT	0.338000													5	60					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109727676	109727676	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:109727676C>G	ENST00000369939.3	+	8	1145	c.962C>G	c.(961-963)tCt>tGt	p.S321C	KIAA1324_ENST00000529753.1_Intron	NM_020775.4	NP_065826	Q6UXG2	K1324_HUMAN	KIAA1324	321					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GAGAAAGGATCTTCTTCCTGT	0.488000													39	69					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57852590	57852590	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:57852590C>T	ENST00000431623.2	+	2	212	c.16C>T	c.(16-18)Cag>Tag	p.Q6*	POLR2B_ENST00000441246.2_Silent_p.I23I|POLR2B_ENST00000314595.5_Silent_p.I30I|POLR2B_ENST00000381227.1_Silent_p.I30I			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	0					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					GGATTGTAATCAGGTAACTTT	0.343000													26	57					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32216236	32216236	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:32216236G>C	ENST00000492345.1	+	9	1652	c.967G>C	c.(967-969)Gac>Cac	p.D323H	CBFA2T2_ENST00000342704.6_Missense_Mutation_p.D343H|CBFA2T2_ENST00000375279.2_Missense_Mutation_p.D352H|CBFA2T2_ENST00000491618.1_3'UTR|CBFA2T2_ENST00000397800.1_Missense_Mutation_p.D323H|CBFA2T2_ENST00000346541.3_Missense_Mutation_p.D352H|CBFA2T2_ENST00000359606.3_Missense_Mutation_p.D362H			O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	352						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						GAAACATCTTGACCATGTAAG	0.393000													22	59					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71960644	71960644	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:71960644C>T	ENST00000266674.5	+	11	1333	c.1022C>T	c.(1021-1023)tCa>tTa	p.S341L	LGR5_ENST00000540815.2_Missense_Mutation_p.S317L|LGR5_ENST00000536515.1_Missense_Mutation_p.S269L			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	341						integral to plasma membrane	protein-hormone receptor activity	p.S341*(1)	NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						GCACAGATCTCATCTCTTCCT	0.398000													20	31					0	0	1	0	0
CAMK2D	817	broad.mit.edu	37	4	114473230	114473230	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:114473230C>T	ENST00000454265.2	-	5	1156	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	CAMK2D_ENST00000296402.5_Missense_Mutation_p.E100K|CAMK2D_ENST00000342666.5_Missense_Mutation_p.E100K|CAMK2D_ENST00000418639.2_Missense_Mutation_p.E100K|CAMK2D_ENST00000515496.1_Missense_Mutation_p.E100K|CAMK2D_ENST00000505990.1_Missense_Mutation_p.E100K|CAMK2D_ENST00000508738.1_Missense_Mutation_p.E100K|CAMK2D_ENST00000429180.1_Missense_Mutation_p.E100K|CAMK2D_ENST00000394524.3_Missense_Mutation_p.E100K|CAMK2D_ENST00000514328.1_Missense_Mutation_p.E100K|CAMK2D_ENST00000511664.1_Missense_Mutation_p.E100K|CAMK2D_ENST00000379773.2_Missense_Mutation_p.E100K|CAMK2D_ENST00000394526.2_Missense_Mutation_p.E100K|CAMK2D_ENST00000394522.3_Missense_Mutation_p.E100K			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	100	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		ACTATGTCTTCAAACAGTTCA	0.348000													20	33					0	0	1	0	0
PLA2G15	23659	broad.mit.edu	37	16	68293372	68293372	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:68293372G>A	ENST00000219345.5	+	6	1134	c.1051G>A	c.(1051-1053)Gac>Aac	p.D351N	PLA2G15_ENST00000566188.1_3'UTR|PLA2G15_ENST00000413021.2_Missense_Mutation_p.D257N|PLA2G15_ENST00000444212.2_Missense_Mutation_p.D151N|RP11-96D1.7_ENST00000563175.1_RNA	NM_012320.3	NP_036452.1	Q8NCC3	PAG15_HUMAN	phospholipase A2, group XV	351					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			kidney(2)|large_intestine(2)|lung(2)|ovary(2)|prostate(3)|skin(1)	12						CCCTGACCGTGACCCTAAAAT	0.587000													62	50					0	0	1	0	0
GARS	2617	broad.mit.edu	37	7	30643165	30643165	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:30643165G>A	ENST00000389266.3	+	6	953	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K		NM_002047.2	NP_002038.2	P41250	SYG_HUMAN	glycyl-tRNA synthetase	238					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	24					Glycine(DB00145)	AAAGAAATCAGAAATGGAAAG	0.378000													17	35					0	0	1	0	0
SDHD	6392	broad.mit.edu	37	11	111965609	111965609	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:111965609C>T	ENST00000528048.1	+	3	285	c.250C>T	c.(250-252)Cag>Tag	p.Q84*	SDHD_ENST00000532699.1_Intron|SDHD_ENST00000528182.1_Nonsense_Mutation_p.Q130*|SDHD_ENST00000525291.1_Missense_Mutation_p.S93L|SDHD_ENST00000526592.1_3'UTR|SDHD_ENST00000375549.3_Missense_Mutation_p.S132L|SDHD_ENST00000528021.1_Intron			O14521	DHSD_HUMAN	succinate dehydrogenase complex, subunit D, integral membrane protein	0					respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II	electron carrier activity|heme binding|succinate dehydrogenase activity|ubiquinone binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	9		all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.13e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;1.05e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0515)	Succinic acid(DB00139)	TTGGCACTTTCAGCTTTAACC	0.453000			"""Mis, N, F, S"""			"""paraganglioma, pheochromocytoma"""			Familial Paragangliomas;Cowden syndrome;Carney-Stratakis syndrome				25	33					0	0	1	0	0
ROGDI	79641	broad.mit.edu	37	16	4847736	4847736	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:4847736G>C	ENST00000322048.7	-	10	1179	c.801C>G	c.(799-801)ctC>ctG	p.L267L		NM_024589.2	NP_078865.1	Q9GZN7	ROGDI_HUMAN	rogdi homolog (Drosophila)	267						intracellular				endometrium(2)|lung(1)|ovary(1)|skin(1)	5						GCTGCTGGCAGAGCTGCAGGG	0.637000													24	69					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77691982	77691982	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:77691982C>G	ENST00000296043.6	+	10	6506	c.5553C>G	c.(5551-5553)ctC>ctG	p.L1851L	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1851	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			TGCTCTCCCTCTCGGGGCGTC	0.517000													13	70					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49414918	49414918	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:49414918C>T	ENST00000374201.3	-	14	1972	c.1670G>A	c.(1669-1671)aGg>aAg	p.R557K	FRMPD2_ENST00000407470.4_Missense_Mutation_p.R525K|FRMPD2_ENST00000305531.3_Missense_Mutation_p.R532K	NM_001018071.3|NM_001042512.2	NP_001018081|NP_001035977.2	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	557	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		TTCTGGCCTCCTCTTCTCTGA	0.493000													24	58					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	177030376	177030376	+	Silent	SNP	G	G	A	rs143377268		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:177030376G>A	ENST00000367654.3	-	2	520	c.309C>T	c.(307-309)atC>atT	p.I103I	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Silent_p.I103I|ASTN1_ENST00000367657.3_Silent_p.I103I|ASTN1_ENST00000361833.2_Silent_p.I103I	NM_004319.1	NP_004310.1	O14525	ASTN1_HUMAN	astrotactin 1						cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GCACCAAAGGGATATCCTCTG	0.502000													17	179					0	0	1	0	0
HEATR5B	54497	broad.mit.edu	37	2	37227882	37227882	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:37227882C>G	ENST00000233099.5	-	33	5487	c.5392G>C	c.(5392-5394)Gat>Cat	p.D1798H	HEATR5B_ENST00000354531.2_Missense_Mutation_p.D1709H	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1798							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				ACCTGATTATCTGCAGACTTT	0.403000													17	38					0	0	1	0	0
YY2	404281	broad.mit.edu	37	X	21875005	21875005	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:21875005C>T	ENST00000429584.2	+	1	901	c.403C>T	c.(403-405)Cag>Tag	p.Q135*	MBTPS2_ENST00000379484.5_Intron|MBTPS2_ENST00000365779.2_Intron|MBTPS2_ENST00000465888.1_3'UTR	NM_206923.3	NP_996806.2	O15391	TYY2_HUMAN	YY2 transcription factor	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(2)	19						AACATCAACCCAGagccgcag	0.617000													15	29					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41752065	41752065	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:41752065G>C	ENST00000352645.4	+	20	2639	c.2382G>C	c.(2380-2382)aaG>aaC	p.K794N	ZC3H7B_ENST00000351589.4_Splice_Site_p.K794N	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	810					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						AGGAGAACAAGAGTGAGTGGG	0.612000													6	14					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72344991	72344991	+	Silent	SNP	A	A	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:72344991A>G	ENST00000299687.5	+	1	2016	c.2016A>G	c.(2014-2016)aaA>aaG	p.K672K	ZNF407_ENST00000309902.6_Silent_p.K672K|ZNF407_ENST00000577538.1_Silent_p.K672K|ZNF407_ENST00000582337.1_Silent_p.K672K	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	672					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AAAACGCAAAAGAGTCTATGG	0.388000													14	9					0	0	1	0	0
CCL3	6348	broad.mit.edu	37	17	34416544	34416544	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:34416544G>A	ENST00000225245.5	-	2	255	c.173C>T	c.(172-174)tCc>tTc	p.S58F	AC069363.1_ENST00000592728.1_RNA|AC069363.1_ENST00000441575.1_RNA|AC069363.1_ENST00000590992.1_RNA	NM_002983.2	NP_002974.1	P10147	CCL3_HUMAN	chemokine (C-C motif) ligand 3	58					cell-cell signaling|cellular calcium ion homeostasis|cellular component movement|cytoskeleton organization|exocytosis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|regulation of viral genome replication	extracellular space|soluble fraction	chemoattractant activity|chemokine activity|signal transducer activity			breast(2)|lung(3)|urinary_tract(1)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACCGGGCTTGGAGCACTGGCT	0.577000													19	81					0	0	1	0	0
ARF1	375	broad.mit.edu	37	1	228285296	228285296	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:228285296G>A	ENST00000541182.1	+	4	526	c.264G>A	c.(262-264)ctG>ctA	p.L88L	ARF1_ENST00000272102.5_Silent_p.L88L|ARF1_ENST00000478424.1_3'UTR|ARF1_ENST00000540651.1_Silent_p.L88L	NM_001024227.1|NM_001024228.1	NP_001019398.1|NP_001019399.1	P84077	ARF1_HUMAN	ADP-ribosylation factor 1	88					cellular copper ion homeostasis|COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|protein transport|regulation of defense response to virus by virus|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction|viral reproduction	cytosol|Golgi membrane|perinuclear region of cytoplasm|plasma membrane	GTP binding|GTPase activity|protein binding|receptor signaling protein activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)	10		Prostate(94;0.0405)				CGGCAGGCCTGATCTTCGTGG	0.632000													29	93					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60749412	60749412	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:60749412G>C	ENST00000303375.5	+	8	1762	c.1360G>C	c.(1360-1362)Gag>Cag	p.E454Q		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	454	C-type lectin 2.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GATGAATTTTGAGTGGTCTGA	0.567000													27	78					0	0	1	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	17958826	17958826	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:17958826C>G	ENST00000361221.3	+	16	1754	c.1595C>G	c.(1594-1596)tCa>tGa	p.S532*	ARHGEF10L_ENST00000375408.3_Nonsense_Mutation_p.S310*|ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000375415.1_Nonsense_Mutation_p.S493*|ARHGEF10L_ENST00000452522.1_Nonsense_Mutation_p.S493*|ARHGEF10L_ENST00000375420.3_Nonsense_Mutation_p.S290*|ARHGEF10L_ENST00000167825.4_Nonsense_Mutation_p.S240*|ARHGEF10L_ENST00000434513.1_Nonsense_Mutation_p.S532*	NM_018125.3	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	532					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CTGTTGACCTCAGGCCAGCGG	0.632000													28	68					0	0	1	0	0
SRP72	6731	broad.mit.edu	37	4	57340298	57340298	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:57340298G>A	ENST00000342756.5	+	4	1154	c.433G>A	c.(433-435)Gag>Aag	p.E145K	SRP72_ENST00000504757.1_Missense_Mutation_p.E145K|SRP72_ENST00000510663.1_Missense_Mutation_p.E145K	NM_006947.3	NP_008878.3	O76094	SRP72_HUMAN	signal recognition particle 72kDa	145					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(7)|ovary(2)	22	Glioma(25;0.08)|all_neural(26;0.101)					TGATTATGATGAGGAGAGGAA	0.403000													25	37					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53670401	53670401	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:53670401C>T	ENST00000262135.4	-	21	3235	c.3142G>A	c.(3142-3144)Gac>Aac	p.D1048N	RPGRIP1L_ENST00000568009.1_5'UTR|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.D1082N|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.D1082N|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.D1048N	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	1082					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				TCATCACTGTCAGAAGCTGAC	0.348000													21	39					0	0	1	0	0
TNRC6C	57690	broad.mit.edu	37	17	76045867	76045867	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:76045867G>T	ENST00000335749.4	+	3	1293	c.724G>T	c.(724-726)Gaa>Taa	p.E242*	TNRC6C_ENST00000588847.1_Nonsense_Mutation_p.E242*|TNRC6C_ENST00000541771.1_Nonsense_Mutation_p.E242*|TNRC6C_ENST00000544502.1_Nonsense_Mutation_p.E242*|TNRC6C_ENST00000588061.1_Nonsense_Mutation_p.E242*|TNRC6C_ENST00000301624.4_Nonsense_Mutation_p.E242*	NM_001142640.1	NP_001136112.1	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C	242	Gly-rich.|Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GGGCAGTGCTGAAGGAATAAG	0.547000													23	43					1.55469e-16	1.64624e-16	1	1	0
WHSC1L1	54904	broad.mit.edu	37	8	38133176	38133176	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:38133176C>T	ENST00000317025.8	-	24	4814	c.4297G>A	c.(4297-4299)Gaa>Aaa	p.E1433K	WHSC1L1_ENST00000527502.1_Missense_Mutation_p.E1422K|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.E1384K	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	1433					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TTTACTTCTTCTCCATGATCT	0.418000			T	NUP98	AML								3	25					0	0	1	0	0
PLK3	1263	broad.mit.edu	37	1	45267308	45267308	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:45267308C>T	ENST00000372201.4	+	4	689	c.450C>T	c.(448-450)atC>atT	p.I150I	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	150	Protein kinase.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					TGGCCCACATCTGGAAGGCCC	0.642000													11	31					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79362367	79362367	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:79362367G>C	ENST00000264895.6	+	41	6021	c.5581G>C	c.(5581-5583)Gat>Cat	p.D1861H	FRAS1_ENST00000325942.6_Missense_Mutation_p.D1861H	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1860					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TTTTGCTACTGATGATGATGA	0.423000													7	11					0	0	1	0	0
TBX2	6909	broad.mit.edu	37	17	59485544	59485544	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:59485544C>G	ENST00000240328.3	+	7	2097	c.1816C>G	c.(1816-1818)Ctc>Gtc	p.L606V	RP11-332H18.4_ENST00000592009.1_RNA	NM_005994.3	NP_005985.3	Q13207	TBX2_HUMAN	T-box 2	606					cell aging|positive regulation of cell proliferation		sequence-specific DNA binding			endometrium(1)|lung(7)|ovary(1)	9						cgccgGCTCCCTCTCCCGGAG	0.697000													8	19					0	0	1	0	0
DDX5	1655	broad.mit.edu	37	17	62499397	62499397	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:62499397C>G	ENST00000225792.5	-	7	1120	c.719G>C	c.(718-720)aGa>aCa	p.R240T	DDX5_ENST00000450599.2_Missense_Mutation_p.R161T|DDX5_ENST00000578804.1_Missense_Mutation_p.R240T	NM_004396.3	NP_004387.1	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 5	240	Helicase ATP-binding.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	19	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			GGTTGTTCTTCTCAGATTGGT	0.368000			T	ETV4	prostate								30	60					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9914842	9914842	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:9914842C>T	ENST00000380913.3	+	10	4806	c.4716C>T	c.(4714-4716)ctC>ctT	p.L1572L	SHROOM2_ENST00000418909.2_Silent_p.L407L	NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	1572	ASD2.				apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				AGGAGAGCCTCGCGGACTATG	0.562000													3	10					0	0	1	0	0
MMD2	221938	broad.mit.edu	37	7	4947196	4947196	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:4947196C>G	ENST00000404774.3	-	7	838	c.644G>C	c.(643-645)gGa>gCa	p.G215A	MMD2_ENST00000406755.1_3'UTR|MMD2_ENST00000401401.3_Missense_Mutation_p.G191A	NM_001100600.1	NP_001094070.1	Q8IY49	PAQRA_HUMAN	monocyte to macrophage differentiation-associated 2	215						integral to membrane	receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(11)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		GAAGACCCCTCCGGTCACCAG	0.602000													6	43					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43103014	43103014	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:43103014G>C	ENST00000428554.2	+	18	2746	c.1603G>C	c.(1603-1605)Gat>Cat	p.D535H	CCDC30_ENST00000342022.4_Missense_Mutation_p.D535H|CCDC30_ENST00000390640.4_Missense_Mutation_p.D324H|CCDC30_ENST00000507855.1_Missense_Mutation_p.D324H|CCDC30_ENST00000340612.4_Missense_Mutation_p.D535H			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	535										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						CCAATTTGAAGATGAAATTGG	0.348000													20	29					0	0	1	0	0
PRDX1	5052	broad.mit.edu	37	1	45977049	45977049	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:45977049G>C	ENST00000262746.1	-	6	891	c.552C>G	c.(550-552)atC>atG	p.I184M	PRDX1_ENST00000319248.8_Missense_Mutation_p.I184M|PRDX1_ENST00000372079.1_Missense_Mutation_p.I82M	NM_002574.3|NM_181696.2	NP_002565.1|NP_859047.1	Q06830	PRDX1_HUMAN	peroxiredoxin 1	184					cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	12	Acute lymphoblastic leukemia(166;0.155)					CATCAGGCTTGATGGTATCAC	0.488000													69	149					0	0	1	0	0
NXF4	55999	broad.mit.edu	37	X	101818336	101818336	+	RNA	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:101818336G>A	ENST00000360035.2	+	0	926					NR_002216.1															endometrium(2)|lung(8)	10						ACAGCCTTCTGATGCCCTTCT	0.493000													14	37					0	0	1	0	0
MISP	126353	broad.mit.edu	37	19	757788	757788	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:757788C>T	ENST00000215582.6	+	2	945	c.842C>T	c.(841-843)tCa>tTa	p.S281L		NM_173481.2	NP_775752.1			mitotic spindle positioning																		TCCTTGGCCTCAGTGGAGTCC	0.657000													28	18					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107790501	107790501	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:107790501C>G	ENST00000379028.3	-	33	4239	c.3769G>C	c.(3769-3771)Gac>Cac	p.D1257H	NRCAM_ENST00000413765.2_Missense_Mutation_p.D1133H|NRCAM_ENST00000379024.4_Missense_Mutation_p.D1145H|NRCAM_ENST00000351718.4_Missense_Mutation_p.D1136H|NRCAM_ENST00000522550.2_5'UTR|NRCAM_ENST00000425651.2_Missense_Mutation_p.D1257H			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	1257					angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						TCTCCATAGTCAACTAGGCTG	0.443000													47	93					0	0	1	0	0
COLQ	8292	broad.mit.edu	37	3	15495391	15495391	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:15495391C>G	ENST00000383788.5	-	16	1368	c.1243G>C	c.(1243-1245)Gag>Cag	p.E415Q	COLQ_ENST00000383781.4_Missense_Mutation_p.E405Q|COLQ_ENST00000603808.1_Missense_Mutation_p.E416Q|COLQ_ENST00000383785.2_3'UTR|COLQ_ENST00000383787.2_Missense_Mutation_p.E406Q|COLQ_ENST00000383786.5_Missense_Mutation_p.E381Q|COLQ_ENST00000435459.2_Missense_Mutation_p.E405Q	NM_005677.3	NP_005668.2	Q9Y215	COLQ_HUMAN	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	415					acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft		p.E405K(2)|p.E415K(2)		endometrium(2)|large_intestine(4)|lung(10)|skin(3)	19						TCACAGTCCTCCACACCCTCA	0.587000													6	9					0	0	1	0	0
NUP133	55746	broad.mit.edu	37	1	229635538	229635538	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:229635538C>A	ENST00000261396.3	-	5	632	c.541G>T	c.(541-543)Gaa>Taa	p.E181*	NUP133_ENST00000366678.3_Nonsense_Mutation_p.E181*|NUP133_ENST00000537506.1_Nonsense_Mutation_p.E165*	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	181					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				ATAGATCCTTCTCTGGTGGCA	0.453000													28	40					8.16721e-17	8.66636e-17	1	1	0
DST	667	broad.mit.edu	37	6	56342260	56342260	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:56342260C>G	ENST00000370754.5	-	91	21464	c.21465G>C	c.(21463-21465)aaG>aaC	p.K7155N	DST_ENST00000361203.3_Missense_Mutation_p.K6866N|DST_ENST00000244364.6_Missense_Mutation_p.K4563N|DST_ENST00000370788.2_Missense_Mutation_p.K4780N|DST_ENST00000446842.2_Missense_Mutation_p.K6651N|DST_ENST00000421834.2_Missense_Mutation_p.K4889N|DST_ENST00000370769.4_Missense_Mutation_p.K6977N|DST_ENST00000312431.6_3'UTR			Q03001	DYST_HUMAN	dystonin	6975					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GTTCAGCTCTCTTTTCTTCCA	0.428000													30	79					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8526411	8526411	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:8526411C>G	ENST00000360416.3	-	2	292	c.154G>C	c.(154-156)Gaa>Caa	p.E52Q	MYH10_ENST00000269243.4_Missense_Mutation_p.E52Q|MYH10_ENST00000396239.1_Missense_Mutation_p.E52Q|MYH10_ENST00000379980.4_Missense_Mutation_p.E52Q	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	52	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CCCCGTTCTTCTTTGATACTA	0.443000													60	82					0	0	1	0	0
MAPK3	5595	broad.mit.edu	37	16	30128091	30128091	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:30128091G>A	ENST00000484663.1	-	7	1829	c.696C>T	c.(694-696)ttC>ttT	p.F232F	MAPK3_ENST00000403394.1_3'UTR|MAPK3_ENST00000263025.4_Silent_p.F346F|MAPK3_ENST00000322266.5_Silent_p.F302F|MAPK3_ENST00000395202.1_Silent_p.F302F|MAPK3_ENST00000395200.1_Silent_p.F278F			P27361	MK03_HUMAN	mitogen-activated protein kinase 3	346	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding									Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	TGGCGAAGGTGAAGGGCTCCT	0.667000													11	41					0	0	1	0	0
SLC2A11	66035	broad.mit.edu	37	22	24226515	24226515	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:24226515G>A	ENST00000345044.6	+	11	1457	c.1189G>A	c.(1189-1191)Gag>Aag	p.E397K	SLC2A11_ENST00000398356.2_Missense_Mutation_p.E404K|SLC2A11_ENST00000316185.8_Missense_Mutation_p.E400K|AP000350.10_ENST00000433835.3_Intron			Q9BYW1	GTR11_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 11	397						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						CCTGGCCACAGAGCTGTTTGA	0.647000													5	19					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47585484	47585484	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:47585484G>A	ENST00000253048.5	-	10	1324	c.1287C>T	c.(1285-1287)atC>atT	p.I429I	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	429							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		AAAATCCAGTGATGTAAAACT	0.458000													10	75					0	0	1	0	0
ADAT1	23536	broad.mit.edu	37	16	75642880	75642880	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:75642880C>G	ENST00000307921.3	-	8	1195	c.1050G>C	c.(1048-1050)caG>caC	p.Q350H		NM_012091.3	NP_036223.2	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	350	A to I editase.				tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity	p.Q350H(1)		breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)	19						CAGACACATTCTGACACCTAA	0.428000													18	67					0	0	1	0	0
PDCD6	10016	broad.mit.edu	37	5	311422	311422	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:311422G>C	ENST00000264933.4	+	5	482	c.382G>C	c.(382-384)Gac>Cac	p.D128H	PDCD6_ENST00000505221.1_Intron|PDCD6_ENST00000507528.1_Missense_Mutation_p.D126H|AHRR_ENST00000505113.1_Intron|AHRR_ENST00000316418.5_Intron|PDCD6_ENST00000511482.1_3'UTR|AHRR_ENST00000512529.1_Intron	NM_001267556.1|NM_001267558.1|NM_013232.3	NP_001254485.1|NP_001254487.1|NP_037364.1	O75340	PDCD6_HUMAN	programmed cell death 6	128	EF-hand 4.				induction of apoptosis by extracellular signals|response to calcium ion	endoplasmic reticulum membrane|nuclear membrane	binding, bridging|calcium ion binding|calcium-dependent protein binding			breast(2)|endometrium(1)|large_intestine(4)|lung(1)	8			Epithelial(17;0.00193)|OV - Ovarian serous cystadenocarcinoma(19;0.00489)|all cancers(22;0.00511)|Lung(60;0.113)			CCGGCTCTCTGACCAGTTCCA	0.582000													10	24					0	0	1	0	0
NBPF3	84224	broad.mit.edu	37	1	21771614	21771614	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:21771614G>A	ENST00000318249.5	+	2	385	c.35G>A	c.(34-36)tGg>tAg	p.W12*	NBPF3_ENST00000478653.2_3'UTR|NBPF3_ENST00000342104.5_Nonsense_Mutation_p.W12*|NBPF3_ENST00000454000.2_Nonsense_Mutation_p.W12*|NBPF3_ENST00000318220.6_5'UTR	NM_032264.3	NP_115640.1	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	12						cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	20		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GGCTTCCAGTGGACTCTCCGA	0.592000													4	25					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66467434	66467434	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:66467434C>T	ENST00000273854.3	-	3	1435	c.835G>A	c.(835-837)Gaa>Aaa	p.E279K	EPHA5_ENST00000432638.2_Missense_Mutation_p.E279K|EPHA5_ENST00000354839.4_Missense_Mutation_p.E279K|EPHA5_ENST00000511294.1_Missense_Mutation_p.E279K	NM_001281765.1|NM_004439.5	NP_001268694.1|NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	279	Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity	p.E279K(1)		autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CACTCCCCTTCGGCGCTGCAG	0.522000										TSP Lung(17;0.13)			5	46					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146818149	146818149	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:146818149C>T	ENST00000361727.3	+	6	1349	c.833C>T	c.(832-834)tCt>tTt	p.S278F		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	278	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CACTGGCACTCTGTGGTCATT	0.527000										HNSCC(39;0.1)			10	63					0	0	1	0	0
MTIF2	4528	broad.mit.edu	37	2	55463873	55463873	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:55463873C>G	ENST00000394600.3	-	17	2831	c.2095G>C	c.(2095-2097)Gac>Cac	p.D699H	MTIF2_ENST00000403721.1_Missense_Mutation_p.D699H|MTIF2_ENST00000263629.4_Missense_Mutation_p.D699H	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	699					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						TCCATATTGTCTTCATCTAAA	0.323000													13	39					0	0	1	0	0
HSD17B1	3292	broad.mit.edu	37	17	40705874	40705874	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:40705874C>T	ENST00000585807.1	+	4	4228	c.508C>T	c.(508-510)Ctg>Ttg	p.L170L	HSD17B1_ENST00000225929.5_Silent_p.L170L|RP11-400F19.8_ENST00000585572.1_RNA|RP11-400F19.6_ENST00000590513.1_RNA	NM_000413.2	NP_000404.2	P14061	DHB1_HUMAN	hydroxysteroid (17-beta) dehydrogenase 1	170					estrogen biosynthetic process	cytosol	binding|estradiol 17-beta-dehydrogenase activity			NS(1)|endometrium(1)|kidney(1)|lung(2)	5		all_cancers(22;5.59e-08)|all_epithelial(22;7e-07)|Ovarian(249;0.0261)		BRCA - Breast invasive adenocarcinoma(366;0.129)	NADH(DB00157)	ATGCGAGAGTCTGGCGGTTCT	0.607000													5	18					0	0	1	0	0
DAW1	164781	broad.mit.edu	37	2	228771019	228771019	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:228771019C>G	ENST00000373666.2	+	9	1459	c.823C>G	c.(823-825)Cta>Gta	p.L275V	DAW1_ENST00000309931.2_Missense_Mutation_p.L275V|DAW1_ENST00000545118.1_Missense_Mutation_p.L260V					dynein assembly factor with WDR repeat domains 1																		GGATTGCTCTCTAATATTAAC	0.328000													18	42					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112630890	112630890	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:112630890C>G	ENST00000550722.1	-	58	9018	c.8623G>C	c.(8623-8625)Gaa>Caa	p.E2875Q	HECTD4_ENST00000377560.5_Missense_Mutation_p.E2849Q|HECTD4_ENST00000430131.2_Missense_Mutation_p.E2599Q	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GATTGACTTTCTTTACAAGAC	0.463000													18	24					0	0	1	0	0
XYLB	9942	broad.mit.edu	37	3	38408354	38408354	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:38408354C>G	ENST00000207870.3	+	7	653	c.563C>G	c.(562-564)tCa>tGa	p.S188*	XYLB_ENST00000542835.1_Nonsense_Mutation_p.S51*	NM_005108.3	NP_005099.2	O75191	XYLB_HUMAN	xylulokinase homolog (H. influenzae)	188					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			endometrium(3)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|prostate(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		GAGGCCTACTCACATACGGAG	0.378000													14	36					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237831	29237831	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:29237831C>T	ENST00000382535.3	+	2	1715	c.1346C>T	c.(1345-1347)tCg>tTg	p.S449L	FOXG1_ENST00000313071.4_Missense_Mutation_p.S449L			P55316	FOXG1_HUMAN	forkhead box G1	449				QAPST -> AGPPRP (in Ref. 1; CAA52240 and 2; CAA55038).|ST -> RP (in Ref. 1; CAA52239).	axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CAGGCCCCCTCGACCCTGCCC	0.582000													33	60					0	0	1	0	0
UBXN2B	137886	broad.mit.edu	37	8	59352268	59352268	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:59352268G>A	ENST00000399598.2	+	6	732	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K		NM_001077619.1	NP_001071087.1	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	204	SEP.					cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	13						TCAGGATCAAGAATACATAAA	0.393000													6	76					0	0	1	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95662061	95662061	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:95662061C>T	ENST00000324972.6	+	12	1443	c.1250C>T	c.(1249-1251)tCc>tTc	p.S417F	DYNC1I1_ENST00000359388.4_Missense_Mutation_p.S380F|DYNC1I1_ENST00000447467.2_Missense_Mutation_p.S400F|DYNC1I1_ENST00000537881.1_Missense_Mutation_p.S380F|DYNC1I1_ENST00000497626.1_3'UTR|DYNC1I1_ENST00000437599.1_Missense_Mutation_p.S397F|DYNC1I1_ENST00000457059.1_Missense_Mutation_p.S400F	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	417					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			AAAATGTGTTCCTGGAGCCTG	0.433000													30	50					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101098466	101098466	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:101098466C>T	ENST00000369162.2	-	20	3544	c.3200G>A	c.(3199-3201)cGa>cAa	p.R1067Q		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	1067	SEC63 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CATTTCTCCTCGGCTGATATA	0.353000													18	44					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35714018	35714018	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:35714018C>G	ENST00000314888.9	-	25	3534	c.3181G>C	c.(3181-3183)Gag>Cag	p.E1061Q	TLN1_ENST00000540444.1_Missense_Mutation_p.E1061Q	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1061					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGATCTTTCTCTAGATTCTGT	0.458000													49	24					0	0	1	0	0
CCAR1	55749	broad.mit.edu	37	10	70517109	70517109	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:70517109C>G	ENST00000265872.6	+	15	2014	c.1895C>G	c.(1894-1896)tCt>tGt	p.S632C	CCAR1_ENST00000543719.1_Missense_Mutation_p.S617C|CCAR1_ENST00000535016.1_Missense_Mutation_p.S617C	NM_001282959.1|NM_001282960.1|NM_018237.2	NP_001269888.1|NP_001269889.1|NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	632					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						ACCCATTGGTCTAAACTTGAT	0.323000													22	70					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179485146	179485146	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:179485146C>T	ENST00000589042.1	-	248	46326	c.46102G>A	c.(46102-46104)Gaa>Aaa	p.E15368K	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E6428K|TTN_ENST00000460472.2_Missense_Mutation_p.E6303K|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E12800K|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E13727K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E6495K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13727	Ig-like 97.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTCACCTTCATCTGGGAAG	0.423000													36	80					0	0	1	0	0
RBBP4	5928	broad.mit.edu	37	1	33138292	33138292	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:33138292G>A	ENST00000373493.5	+	10	1252	c.1093G>A	c.(1093-1095)Gag>Aag	p.E365K	RBBP4_ENST00000544435.1_Missense_Mutation_p.E113K|RBBP4_ENST00000373485.1_Missense_Mutation_p.E365K|RBBP4_ENST00000414241.3_Missense_Mutation_p.E364K|RBBP4_ENST00000458695.2_Missense_Mutation_p.E330K	NM_001135255.1|NM_005610.2	NP_001128727.1|NP_005601.1	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4	365					cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CGGGCCACCAGAGTTGTTGGT	0.363000													12	25					0	0	1	0	0
PPHLN1	51535	broad.mit.edu	37	12	42835177	42835177	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:42835177C>G	ENST00000432191.2	+	9	877	c.805C>G	c.(805-807)Cct>Gct	p.P269A	PPHLN1_ENST00000549190.1_Missense_Mutation_p.P342A|PPHLN1_ENST00000358314.7_Missense_Mutation_p.P324A|PPHLN1_ENST00000337898.6_Missense_Mutation_p.P269A|PPHLN1_ENST00000395568.2_Missense_Mutation_p.P324A|PPHLN1_ENST00000449194.2_Missense_Mutation_p.P305A|PPHLN1_ENST00000256678.8_Missense_Mutation_p.P204A|PPHLN1_ENST00000395580.3_Missense_Mutation_p.P331A|PPHLN1_ENST00000317560.9_Missense_Mutation_p.P257A|PPHLN1_ENST00000552761.1_Missense_Mutation_p.P276A	NM_001143787.1	NP_001137259.1	Q8NEY8	PPHLN_HUMAN	periphilin 1	324					keratinization	cytoplasm|nucleus				breast(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	16	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)		TGAAAAAGATCCTTCATTAGA	0.373000													27	59					0	0	1	0	0
CD101	9398	broad.mit.edu	37	1	117576549	117576549	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:117576549C>T	ENST00000256652.4	+	9	2950	c.2892C>T	c.(2890-2892)ttC>ttT	p.F964F	CD101_ENST00000369470.1_Silent_p.F964F|RP11-27K13.3_ENST00000445523.1_RNA|CD101_ENST00000467588.1_3'UTR	NM_001256106.1|NM_001256109.1|NM_001256111.1|NM_004258.4	NP_001243035.1|NP_001243038.1|NP_001243040.1|NP_004249.2	Q93033	IGSF2_HUMAN	CD101 molecule	964					cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(14)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TCTGTCCCTTCGTCCTGCTCC	0.507000													20	70					0	0	1	0	0
FKBP6	8468	broad.mit.edu	37	7	72744195	72744195	+	Missense_Mutation	SNP	G	G	A	rs3950376		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:72744195G>A	ENST00000252037.4	+	4	377	c.308G>A	c.(307-309)cGg>cAg	p.R103Q	FKBP6_ENST00000431982.2_Missense_Mutation_p.R98Q|FKBP6_ENST00000413573.2_Missense_Mutation_p.R73Q	NM_003602.3	NP_003593.3	O75344	FKBP6_HUMAN	FK506 binding protein 6, 36kDa	103	PPIase FKBP-type.				protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity	p.R103Q(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	16		Lung NSC(55;0.0908)|all_lung(88;0.198)				CTGAGCATGCGGAGAGGAGAG	0.537000													3	65					0	0	1	0	0
ACO1	48	broad.mit.edu	37	9	32407326	32407326	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:32407326G>C	ENST00000309951.6	+	3	303	c.165G>C	c.(163-165)gtG>gtC	p.V55V	ACO1_ENST00000541043.1_5'UTR|ACO1_ENST00000379923.1_Silent_p.V55V	NM_002197.2	NP_002188.1	P21399	ACOC_HUMAN	aconitase 1, soluble						citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding			breast(1)|endometrium(7)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	30			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		AGTTTTTGGTGAAGAAACAGG	0.403000													35	29					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152084601	152084601	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:152084601C>G	ENST00000368804.1	-	2	1091	c.1092G>C	c.(1090-1092)ctG>ctC	p.L364L		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	364	5 X 13 AA tandem repeats of R-R-E-Q-E-E- E-R-R-E-Q-Q-L.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			gctcgcgcctcagctgctgct	0.721000													17	36					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27802816	27802816	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:27802816G>A	ENST00000408964.2	+	1	3428	c.3377G>A	c.(3376-3378)cGa>cAa	p.R1126Q		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1126										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CAGTGTGGCCGATGTTCAGGA	0.473000													35	70					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180063707	180063707	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:180063707G>A	ENST00000367607.3	+	34	8885	c.8467G>A	c.(8467-8469)Gat>Aat	p.D2823N	CEP350_ENST00000490141.1_3'UTR	NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	2823						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TGAATTGGAAGATGAAAAAGA	0.398000													12	16					0	0	1	0	0
IFNAR1	3454	broad.mit.edu	37	21	34725108	34725108	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr21:34725108G>T	ENST00000270139.3	+	9	1340	c.1188G>T	c.(1186-1188)ttG>ttT	p.L396F	IFNAR1_ENST00000416947.2_Missense_Mutation_p.L327F|IFNAR1_ENST00000442357.2_Missense_Mutation_p.L396F	NM_000629.2	NP_000620.2	P17181	INAR1_HUMAN	interferon (alpha, beta and omega) receptor 1	396	Fibronectin type-III 3.				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|skin(2)	14					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	TTCCTAATTTGAAACCACTGA	0.328000													20	38					1.50039e-11	1.57385e-11	1	1	0
PNPLA5	150379	broad.mit.edu	37	22	44285326	44285326	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:44285326G>A	ENST00000216177.4	-	4	717	c.585C>T	c.(583-585)atC>atT	p.I195I	PNPLA5_ENST00000597664.1_Silent_p.I195I|PNPLA5_ENST00000593866.1_Silent_p.I81I|PNPLA5_ENST00000381198.2_Silent_p.I81I	NM_138814.3	NP_620169.1	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	195					lipid catabolic process		hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	16		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				TCTGGGGGCAGATGTCCACTG	0.552000													28	86					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12947860	12947860	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:12947860G>A	ENST00000276297.4	-	15	4384	c.3975C>T	c.(3973-3975)ctC>ctT	p.L1325L	DLC1_ENST00000510318.1_5'UTR|DLC1_ENST00000520226.1_Silent_p.L814L|DLC1_ENST00000358919.2_Silent_p.L888L|DLC1_ENST00000512044.2_Silent_p.L922L	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	1325	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CACAGTCCTGGAGGAAGTGTT	0.502000													14	88					0	0	1	0	0
PNCK	139728	broad.mit.edu	37	X	152938058	152938058	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:152938058C>A	ENST00000393831.2	-	3	597	c.163G>T	c.(163-165)Gag>Tag	p.E55*	PNCK_ENST00000475172.1_5'UTR|PNCK_ENST00000447676.2_Nonsense_Mutation_p.E138*|PNCK_ENST00000370142.1_Nonsense_Mutation_p.E55*|PNCK_ENST00000340888.3_Nonsense_Mutation_p.E55*|PNCK_ENST00000370150.1_Nonsense_Mutation_p.E55*|PNCK_ENST00000370145.4_Nonsense_Mutation_p.E72*	NM_001039582.3	NP_001034671.3	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase	55	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ACCAGGGCCTCCTTGCCCCGG	0.697000													28	70					4.87955e-14	5.14525e-14	1	1	0
NPIPB15	440348	broad.mit.edu	37	16	74425496	74425496	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:74425496G>C	ENST00000429990.1	+	7	946	c.850G>C	c.(850-852)Gag>Cag	p.E284Q						nuclear pore complex interacting protein family, member B15																		TAATATCAAGGAGTGTCCTCT	0.493000													56	213					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138198296	138198296	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:138198296G>A	ENST00000237289.4	+	6	955	c.889G>A	c.(889-891)Gag>Aag	p.E297K	TNFAIP3_ENST00000485192.1_3'UTR	NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	297	2 X approximate repeats.|TRAF-binding.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		TCCTGAAAATGAGATGAAGGA	0.403000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								26	43					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377872	113377872	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:113377872G>A	ENST00000316407.4	-	7	3067	c.2657C>T	c.(2656-2658)gCa>gTa	p.A886V	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Missense_Mutation_p.A886V	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	886	Ser-rich.				regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						GGACTTTTCTGCTGACTTAGA	0.423000													34	84					0	0	1	0	0
CXorf23	256643	broad.mit.edu	37	X	19984478	19984478	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:19984478G>A	ENST00000379687.3	-	2	364	c.331C>T	c.(331-333)Cag>Tag	p.Q111*	CXorf23_ENST00000379682.4_Nonsense_Mutation_p.Q111*|CXorf23_ENST00000356980.3_Nonsense_Mutation_p.Q111*	NM_198279.3	NP_938020.2	A2AJT9	CX023_HUMAN	chromosome X open reading frame 23	111						mitochondrion				endometrium(2)|large_intestine(1)|lung(6)|skin(1)|urinary_tract(1)	11						GGCATATACTGAGCTCTCCTG	0.433000													58	95					0	0	1	0	0
C1orf216	127703	broad.mit.edu	37	1	36181726	36181726	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:36181726G>A	ENST00000270815.4	-	2	967	c.197C>T	c.(196-198)tCt>tTt	p.S66F		NM_152374.1	NP_689587.1	Q8TAB5	CA216_HUMAN	chromosome 1 open reading frame 216	66										kidney(2)|lung(3)|skin(2)|urinary_tract(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				TTGGTTGTCAGAGGGTGACTC	0.602000											OREG0013357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	39					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152348672	152348672	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:152348672G>A	ENST00000427231.2	-	178	25199	c.24997C>T	c.(24997-24999)Cag>Tag	p.Q8333*	NEB_ENST00000172853.10_Nonsense_Mutation_p.Q6477*|NEB_ENST00000498015.2_5'UTR|NEB_ENST00000603639.1_Nonsense_Mutation_p.Q8333*|NEB_ENST00000397345.3_Nonsense_Mutation_p.Q8333*|RIF1_ENST00000457745.1_Intron|NEB_ENST00000397336.2_Nonsense_Mutation_p.Q308*|NEB_ENST00000509223.2_Nonsense_Mutation_p.Q246*|NEB_ENST00000604864.1_Nonsense_Mutation_p.Q8333*|NEB_ENST00000409198.1_Nonsense_Mutation_p.Q6477*	NM_001164507.1|NM_001271208.1	NP_001157979|NP_001258137.1	P20929	NEBU_HUMAN	nebulin	6477					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACTTTCCTCTGAATACCTCGG	0.443000													48	110					0	0	1	0	0
MASTL	84930	broad.mit.edu	37	10	27475452	27475452	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:27475452G>A	ENST00000375946.4	+	12	3227	c.2624G>A	c.(2623-2625)gGa>gAa	p.G875E	MASTL_ENST00000477034.1_3'UTR|MASTL_ENST00000342386.6_Missense_Mutation_p.G837E|MASTL_ENST00000375940.4_Missense_Mutation_p.G876E	NM_001172303.1|NM_032844.3	NP_001165774.1|NP_116233.2	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine kinase-like	876	AGC-kinase C-terminal.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			breast(3)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ACTGTATCTGGATTTAGTCTG	0.393000													49	87					0	0	1	0	0
MCM9	254394	broad.mit.edu	37	6	119252668	119252668	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:119252668C>T	ENST00000316316.6	-	2	507	c.221G>A	c.(220-222)cGa>cAa	p.R74Q	MCM9_ENST00000316068.3_Missense_Mutation_p.R74Q	NM_017696.2	NP_060166.2	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	74					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		GGCTGACCTTCGCAGTGCACT	0.433000													21	39					0	0	1	0	0
HADHA	3030	broad.mit.edu	37	2	26427023	26427023	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:26427023G>A	ENST00000380649.3	-	12	1257	c.1128C>T	c.(1126-1128)atC>atT	p.I376I		NM_000182.4	NP_000173.2	P40939	ECHA_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	376					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding	p.I376I(1)		autonomic_ganglia(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(4)|skin(1)	30	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	AGACTTGGGCGATGCCTGCTC	0.488000													88	218					0	0	1	0	0
DOK7	285489	broad.mit.edu	37	4	3487290	3487290	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:3487290C>T	ENST00000340083.5	+	5	622	c.557C>T	c.(556-558)tCg>tTg	p.S186L	DOK7_ENST00000507039.1_Silent_p.L182L|DOK7_ENST00000389653.2_Missense_Mutation_p.S186L	NM_173660.4	NP_775931.3	Q18PE1	DOK7_HUMAN	docking protein 7	186	IRS-type PTB.				positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			kidney(1)|large_intestine(1)|skin(2)|upper_aerodigestive_tract(1)	5				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		TTCCTGTCCTCGGCCGAGGGG	0.652000													4	25					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207172435	207172435	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:207172435G>A	ENST00000374423.3	+	5	3569	c.3183G>A	c.(3181-3183)ttG>ttA	p.L1061L		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1061							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TAGCTTTTTTGAAGGAAAAAC	0.318000													8	32					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183995832	183995832	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:183995832G>A	ENST00000402825.3	+	5	952	c.952G>A	c.(952-954)Gag>Aag	p.E318K	ECE2_ENST00000357474.5_Missense_Mutation_p.E246K|ECE2_ENST00000359140.4_Missense_Mutation_p.E171K|EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000404464.3_Missense_Mutation_p.E200K	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	318	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGACCTCATTGAGAAGGTAGG	0.582000													16	35					0	0	1	0	0
FOXP4	116113	broad.mit.edu	37	6	41555233	41555233	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:41555233C>G	ENST00000373060.1	+	7	1313	c.855C>G	c.(853-855)ctC>ctG	p.L285L	FOXP4_ENST00000307972.4_Silent_p.L285L|FOXP4_ENST00000409208.1_Silent_p.L285L|FOXP4_ENST00000373063.3_Silent_p.L284L|FOXP4_ENST00000373057.3_Silent_p.L283L	NM_001012426.1|NM_001012427.1	NP_001012426.1|NP_001012427.1	Q8IVH2	FOXP4_HUMAN	forkhead box P4	285					embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)					CTACTGTGCTCACATCTCGGA	0.662000											OREG0004065	type=REGULATORY REGION|Gene=FOXP4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	20	51					0	0	1	0	0
ADC	113451	broad.mit.edu	37	1	33585748	33585748	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:33585748G>A	ENST00000294517.6	+	12	1935	c.1348G>A	c.(1348-1350)Gtg>Atg	p.V450M	ADC_ENST00000398167.1_Missense_Mutation_p.V470M|ADC_ENST00000373441.1_Missense_Mutation_p.V470M|ADC_ENST00000484656.1_3'UTR|ADC_ENST00000373443.3_Missense_Mutation_p.V450M	NM_052998.2	NP_443724.1	Q96A70	ADC_HUMAN	arginine decarboxylase	450					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	CACCCTGTGCGTGGGCCCTGT	0.637000													14	45					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1025268	1025268	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:1025268C>G	ENST00000421673.2	-	23	2949	c.2899G>C	c.(2899-2901)Gac>Cac	p.D967H		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	967	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATGCTGATGTCCACGACAAGG	0.657000													25	35					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25264757	25264757	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:25264757C>G	ENST00000218548.6	+	7	1030	c.697C>G	c.(697-699)Ctc>Gtc	p.L233V	ATP12A_ENST00000381946.3_Missense_Mutation_p.L233V	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	233					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TAACTCATCTCTCACGGGGGA	0.517000													20	134					0	0	1	0	0
LRRC45	201255	broad.mit.edu	37	17	79988571	79988571	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:79988571G>A	ENST00000306688.3	+	17	2245	c.1903G>A	c.(1903-1905)Gag>Aag	p.E635K		NM_144999.2	NP_659436.1	Q96CN5	LRC45_HUMAN	leucine rich repeat containing 45	635						centrosome				lung(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	5	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CCGGGAGGCGGAGATCGCCCG	0.697000													4	7					0	0	1	0	0
LRRC71	149499	broad.mit.edu	37	1	156901818	156901818	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:156901818C>T	ENST00000337428.7	+	13	1594	c.1440C>T	c.(1438-1440)atC>atT	p.I480I	LRRC71_ENST00000490146.1_3'UTR	NM_144702.2	NP_653303.2	Q8N4P6	LRC71_HUMAN	leucine rich repeat containing 71	480										endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|stomach(1)	12						TCAACCTCATCCGTATGTCTG	0.582000													7	12					0	0	1	0	0
ERCC6-PGBD3	101243544	broad.mit.edu	37	10	50723918	50723918	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:50723918C>T	ENST00000515869.1	-	6	2767	c.2647G>A	c.(2647-2649)Gat>Aat	p.D883N	PGBD3_ENST00000374127.3_Missense_Mutation_p.D415N|ERCC6-PGBD3_ENST00000447839.2_Missense_Mutation_p.D883N|PGBD3_ENST00000603152.1_Missense_Mutation_p.D883N|ERCC6_ENST00000355832.5_Intron|PGBD3_ENST00000508005.2_Missense_Mutation_p.D415N	NM_001277059.1	NP_001263988.1																					ACACTGTTATCATTCCATCTG	0.408000													16	85					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78540152	78540152	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:78540152G>A	ENST00000397909.2	+	21	4860	c.4687G>A	c.(4687-4689)Gaa>Aaa	p.E1563K	NAV3_ENST00000228327.6_Intron|NAV3_ENST00000536525.2_Missense_Mutation_p.E1563K|NAV3_ENST00000266692.7_Intron			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1563						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TTTACAGGCTGAAGAAAAGGC	0.239000										HNSCC(70;0.22)			6	21					0	0	1	0	0
PRRT2	112476	broad.mit.edu	37	16	29825761	29825761	+	Silent	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:29825761C>A	ENST00000358758.7	+	3	1270	c.987C>A	c.(985-987)atC>atA	p.I329I	PRRT2_ENST00000567659.1_Silent_p.I329I|AC009133.20_ENST00000569039.1_RNA|PRRT2_ENST00000300797.6_3'UTR	NM_001256442.1|NM_001256443.1|NM_145239.2	NP_001243371.1|NP_001243372.1|NP_660282.2	Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	329					response to biotic stimulus	integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	8						TCATCATCATCGCCTCCTGCG	0.642000													19	45					1.33834e-09	1.38653e-09	1	1	0
GALE	2582	broad.mit.edu	37	1	24125177	24125177	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:24125177C>T	ENST00000374497.3	-	4	256	c.165G>A	c.(163-165)ctG>ctA	p.L55L	GALE_ENST00000470383.1_5'UTR	NM_000403.3|NM_001008216.1|NM_001127621.1	NP_000394.2|NP_001008217.1|NP_001121093.1	Q14376	GALE_HUMAN	UDP-galactose-4-epimerase	55					galactose catabolic process	cytosol	coenzyme binding|protein homodimerization activity|UDP-glucose 4-epimerase activity			endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(2)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		AGCGGCCTGTCAGCTCCTGGA	0.612000													6	10					0	0	1	0	0
NRBP1	29959	broad.mit.edu	37	2	27663526	27663526	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:27663526C>G	ENST00000233557.3	+	14	1982	c.1150C>G	c.(1150-1152)Cag>Gag	p.Q384E	NRBP1_ENST00000379863.3_Missense_Mutation_p.Q392E|NRBP1_ENST00000379852.3_Missense_Mutation_p.Q384E			Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein 1	384					ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					CAGGTACTCTCAGTCACCAGC	0.458000													7	38					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7793898	7793898	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:7793898G>T	ENST00000380358.4	+	3	401	c.400G>T	c.(400-402)Gag>Tag	p.E134*	CHD3_ENST00000330494.7_Nonsense_Mutation_p.E75*|CHD3_ENST00000358181.4_Nonsense_Mutation_p.E75*|CHD3_ENST00000570758.1_3'UTR	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	75					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				GGACAGTGAGGAGGAATTTGG	0.448000													2	1					0.0784	0.078556	1	1	0
GPR112	139378	broad.mit.edu	37	X	135427390	135427390	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:135427390C>T	ENST00000394143.1	+	6	1816	c.1525C>T	c.(1525-1527)Ctc>Ttc	p.L509F	GPR112_ENST00000287534.4_Missense_Mutation_p.L446F|GPR112_ENST00000394141.1_Missense_Mutation_p.L304F|GPR112_ENST00000412101.1_Missense_Mutation_p.L304F|GPR112_ENST00000370652.1_Missense_Mutation_p.L509F	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	509					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TTCATTGACTCTCCCAACTAG	0.423000													19	68					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1394021	1394021	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:1394021G>C	ENST00000446702.2	+	12	2005	c.1378G>C	c.(1378-1380)Gag>Cag	p.E460Q	CNTN6_ENST00000350110.2_Missense_Mutation_p.E460Q|CNTN6_ENST00000539053.1_Missense_Mutation_p.E388Q			Q9UQ52	CNTN6_HUMAN	contactin 6	460	Ig-like C2-type 5.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		ATTTCTCTTGGAGGATGGCAG	0.338000													19	43					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6484035	6484035	+	Silent	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:6484035C>A	ENST00000263125.5	-	16	1755	c.1656G>T	c.(1654-1656)ctG>ctT	p.L552L	PRKCQ_ENST00000539722.1_Silent_p.L427L|PRKCQ_ENST00000397176.2_Intron	NM_001282644.1|NM_006257.3	NP_001269573.1|NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	552	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						ATTTCTGACCCAGCAAGATCT	0.507000													13	25					4.36969e-10	4.53637e-10	1	1	0
CASC1	55259	broad.mit.edu	37	12	25267707	25267707	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:25267707C>G	ENST00000354189.5	-	13	1703	c.1668G>C	c.(1666-1668)ttG>ttC	p.L556F	CASC1_ENST00000545133.1_Missense_Mutation_p.L433F|CASC1_ENST00000395987.3_Missense_Mutation_p.L498F|CASC1_ENST00000537577.1_Missense_Mutation_p.L380F|CASC1_ENST00000320267.9_Missense_Mutation_p.L492F|CASC1_ENST00000557684.1_5'UTR|CASC1_ENST00000395990.2_Missense_Mutation_p.L452F	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	492										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			CATCTTGAATCAAGGTAACAG	0.388000													17	41					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86266526	86266526	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:86266526G>A	ENST00000394518.2	+	26	6815	c.6720G>A	c.(6718-6720)ctG>ctA	p.L2240L	AKAP13_ENST00000361243.2_Silent_p.L2244L|AKAP13_ENST00000394510.2_Silent_p.L485L|AKAP13_ENST00000560579.1_3'UTR	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	2240	Interaction with ESR1.|PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GTGTGTTTCTGAAGAATGCAG	0.423000													10	34					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47841934	47841934	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr21:47841934G>T	ENST00000359568.5	+	32	7182	c.7075G>T	c.(7075-7077)Gag>Tag	p.E2359*	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2359					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					AGGAGGCCCTGAGGCTCAAAC	0.607000													16	52					6.31663e-08	6.49066e-08	1	1	0
AQR	9716	broad.mit.edu	37	15	35178756	35178756	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:35178756C>T	ENST00000156471.5	-	25	3013	c.2788G>A	c.(2788-2790)Gaa>Aaa	p.E930K		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	930						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		CCTGCAGTTTCACAGGTATAT	0.378000													26	83					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5905654	5905654	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:5905654G>C	ENST00000378961.4	+	5	2197	c.1993G>C	c.(1993-1995)Gaa>Caa	p.E665Q		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	665						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						AATGGATTTGGAACTACAGAA	0.438000													11	29					0	0	1	0	0
CLNS1A	1207	broad.mit.edu	37	11	77330732	77330732	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:77330732C>G	ENST00000525428.1	-	6	745	c.655G>C	c.(655-657)Gag>Cag	p.E219Q	CLNS1A_ENST00000263309.3_Missense_Mutation_p.E185Q|CLNS1A_ENST00000525064.1_Missense_Mutation_p.E161Q|CLNS1A_ENST00000528364.1_Missense_Mutation_p.E219Q|CLNS1A_ENST00000532069.1_Missense_Mutation_p.E149Q	NM_001293.2	NP_001284.1	P54105	ICLN_HUMAN	chloride channel, nucleotide-sensitive, 1A	219					blood circulation|cell volume homeostasis|chloride transport|ncRNA metabolic process|spliceosomal snRNP assembly	cytoskeleton|cytosol|nucleus|plasma membrane	protein binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	5	all_cancers(14;5.43e-17)|all_epithelial(13;1.78e-19)		Epithelial(5;1.02e-48)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			GTATCCACCTCCATCCCATCT	0.388000													14	126					0	0	1	0	0
GRP	2922	broad.mit.edu	37	18	56897662	56897662	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:56897662C>G	ENST00000256857.2	+	3	507	c.409C>G	c.(409-411)Caa>Gaa	p.Q137E	GRP_ENST00000420468.2_Missense_Mutation_p.Q130E|GRP_ENST00000529320.2_Silent_p.L130L	NM_001012512.1|NM_002091.3	NP_001012530.1|NP_002082.2	P07492	GRP_HUMAN	gastrin-releasing peptide	137					neuropeptide signaling pathway	extracellular space	neuropeptide hormone activity			large_intestine(1)|lung(3)	4		Colorectal(73;0.0946)				TCCAGGTTCTCAACGTGAAGG	0.428000													24	22					0	0	1	0	0
C3orf70	285382	broad.mit.edu	37	3	184870595	184870595	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:184870595G>A	ENST00000335012.2	-	1	207	c.17C>T	c.(16-18)tCg>tTg	p.S6L		NM_001025266.1	NP_001020437.1	A6NLC5	CC070_HUMAN	chromosome 3 open reading frame 70	6								p.S6L(2)		breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|urinary_tract(1)	13						CGACGCCGGCGAGGCCGCCGC	0.716000													11	16					0	0	1	0	0
MALT1	10892	broad.mit.edu	37	18	56376610	56376610	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:56376610G>A	ENST00000348428.3	+	5	908	c.650G>A	c.(649-651)aGa>aAa	p.R217K	MALT1_ENST00000345724.3_Splice_Site_p.R217K|RP11-126O1.4_ENST00000588835.1_RNA	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	217	Ig-like C2-type 2.	Breakpoint for translocation to form BIRC2-MALT1.			activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						TTAATTTAAGGAAGTGTTGAT	0.343000			T	BIRC3	MALT								13	36					0	0	1	0	0
PIK3CB	5291	broad.mit.edu	37	3	138374305	138374305	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:138374305C>T	ENST00000477593.1	-	23	3212	c.3139G>A	c.(3139-3141)Gag>Aag	p.E1047K	PIK3CB_ENST00000544716.1_Missense_Mutation_p.E498K|PIK3CB_ENST00000289153.2_Missense_Mutation_p.E1047K			P42338	PK3CB_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	1047	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E1047K(1)		NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						CTGAGCGCCTCATCAAATTTT	0.408000													25	60					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90190165	90190165	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:90190165G>A	ENST00000394412.3	-	7	1760	c.1684C>T	c.(1684-1686)Cga>Tga	p.R562*		NM_198525.2	NP_940927.2	Q2M1P5	KIF7_HUMAN	kinesin family member 7	562					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	25	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GTATGAGGTCGAGGCACAAAG	0.692000											OREG0023460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	19					0	0	1	0	0
KIAA1841	84542	broad.mit.edu	37	2	61310373	61310373	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:61310373C>G	ENST00000402291.1	+	8	1055	c.814C>G	c.(814-816)Ctt>Gtt	p.L272V	KIAA1841_ENST00000356719.2_Missense_Mutation_p.L272V|KIAA1841_ENST00000295031.5_Missense_Mutation_p.L272V|KIAA1841_ENST00000482513.1_3'UTR|KIAA1841_ENST00000453873.1_Missense_Mutation_p.L272V	NM_001129993.1	NP_001123465.1	Q6NSI8	K1841_HUMAN	KIAA1841	272										breast(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	25			Epithelial(17;0.193)			TAATGCAAATCTTCTCACACG	0.299000													26	62					0	0	1	0	0
B3GAT1	27087	broad.mit.edu	37	11	134254017	134254017	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:134254017C>T	ENST00000524765.1	-	3	4722	c.178G>A	c.(178-180)Gac>Aac	p.D60N	B3GAT1_ENST00000312527.4_Missense_Mutation_p.D60N|B3GAT1_ENST00000531510.1_5'UTR|B3GAT1_ENST00000537389.1_Missense_Mutation_p.D73N|B3GAT1_ENST00000392580.1_Missense_Mutation_p.D60N			Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	60					carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		ATGTCGCGGTCAGACGTGCAG	0.692000													5	11					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90167053	90167053	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:90167053C>G	ENST00000268138.7	+	20	3617	c.3512C>G	c.(3511-3513)tCa>tGa	p.S1171*	TICRR_ENST00000560985.1_Nonsense_Mutation_p.S1170*|KIF7_ENST00000558928.1_Intron					TOPBP1-interacting checkpoint and replication regulator																		CCATTGGATTCAAAAATCACT	0.493000													4	98					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13768147	13768147	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:13768147G>A	ENST00000609686.1	-	7	1764	c.1555C>T	c.(1555-1557)Cga>Tga	p.R519*		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B						response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACCTCCGATCGTTCCTCATTG	0.517000													21	38					0	0	1	0	0
SCML2	10389	broad.mit.edu	37	X	18275147	18275147	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:18275147G>C	ENST00000251900.4	-	11	1436	c.1277C>G	c.(1276-1278)tCc>tGc	p.S426C	SCML2_ENST00000398048.3_Missense_Mutation_p.S162C	NM_006089.2	NP_006080.1	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2 (Drosophila)	426					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	36	Hepatocellular(33;0.183)					CCCATCAAAGGAGGCTATTGG	0.403000													23	44					0	0	1	0	0
MITF	4286	broad.mit.edu	37	3	69915496	69915496	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:69915496C>T	ENST00000314589.5	+	1	67	c.55C>T	c.(55-57)Ctc>Ttc	p.L19F	MITF_ENST00000352241.4_Intron|MITF_ENST00000448226.2_Intron|MITF_ENST00000328528.6_Intron|MITF_ENST00000472437.1_Intron			O75030	MITF_HUMAN	microphthalmia-associated transcription factor	499					melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(6)|stomach(1)|urinary_tract(2)	30		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		AAGCTTGTATCTGTAAGTGAA	0.413000			A		melanoma		"""Waardenburg syndrome type 2, Tietz syndrome"""						11	80					0	0	1	0	0
PPP2R3B	28227	broad.mit.edu	37	X	306333	306333	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:306333G>A	ENST00000390665.3	-	7	972	c.954C>T	c.(952-954)gtC>gtT	p.V318V		NM_013239.4	NP_037371.2	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'', beta	318					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			endometrium(5)|lung(5)|skin(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGCAGTAGATGACGTAGAAAT	0.617000													23	49					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983323	97983323	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:97983323C>G	ENST00000383696.2	+	1	236	c.195C>G	c.(193-195)atC>atG	p.I65M	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TTGTTCTCATCTGGAAAGACC	0.418000													82	228					0	0	1	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140870916	140870916	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:140870916C>G	ENST00000252087.1	+	1	2109	c.2109C>G	c.(2107-2109)ctC>ctG	p.L703L	PCDHGA12_ENST00000252085.3_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGC4_ENST00000306593.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018929.2|NM_032403.2|NM_032407.1	NP_061752.1|NP_115779.1|NP_115783.1	Q9Y5F6	PCDGM_HUMAN		703					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGTCAGTCTCTTATCCCTAG	0.567000													22	98					0	0	1	0	0
DDX18	8886	broad.mit.edu	37	2	118578755	118578755	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:118578755C>T	ENST00000263239.2	+	4	661	c.533C>T	c.(532-534)tCg>tTg	p.S178L	DDX18_ENST00000474694.1_3'UTR	NM_006773.3	NP_006764.3	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	178							ATP binding|ATP-dependent RNA helicase activity|RNA binding	p.S178L(1)		breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GAGGATACTTCGTTTGCTTCT	0.299000													14	36					0	0	1	0	0
LINC01317	104355287	broad.mit.edu	37	2	33952636	33952636	+	RNA	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:33952636G>A	ENST00000366209.2	+	0	68				MYADML_ENST00000474610.1_RNA																							CCACACAGGCGATGCCAGAGA	0.657000													5	10					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89391234	89391234	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:89391234C>G	ENST00000336596.2	+	5	1525	c.1300C>G	c.(1300-1302)Cag>Gag	p.Q434E	EPHA3_ENST00000494014.1_Missense_Mutation_p.Q434E|EPHA3_ENST00000452448.2_Missense_Mutation_p.Q434E	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	434						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CACAACTAATCAGGCTGGTGA	0.458000										TSP Lung(6;0.00050)			14	38					0	0	1	0	0
GPR157	80045	broad.mit.edu	37	1	9188805	9188805	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:9188805G>A	ENST00000377411.4	-	1	424	c.282C>T	c.(280-282)ttC>ttT	p.F94F	GPR157_ENST00000414642.2_Silent_p.F94F	NM_024980.4	NP_079256.4	Q5UAW9	GP157_HUMAN	G protein-coupled receptor 157	94						integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(4)|prostate(1)	5	all_lung(157;0.185)	all_epithelial(116;5.02e-20)|all_lung(118;3.6e-06)|Lung NSC(185;7.93e-06)|Renal(390;0.000147)|Breast(348;0.000688)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.16e-07)|COAD - Colon adenocarcinoma(227;7.73e-05)|Kidney(185;0.000252)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.00178)|BRCA - Breast invasive adenocarcinoma(304;0.00186)|READ - Rectum adenocarcinoma(331;0.0642)		CGGTCCAGAAGAAGGAGCTGG	0.652000													5	18					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73197089	73197089	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:73197089G>A	ENST00000545377.1	+	31	4230	c.4054G>A	c.(4054-4056)Gtc>Atc	p.V1352I	ARHGEF28_ENST00000437974.1_Missense_Mutation_p.V1352I|ARHGEF28_ENST00000296794.6_Missense_Mutation_p.V1352I|ARHGEF28_ENST00000287898.5_Missense_Mutation_p.V1308I|ARHGEF28_ENST00000426542.2_Missense_Mutation_p.V1352I|ARHGEF28_ENST00000296799.4_Missense_Mutation_p.V1039I|ARHGEF28_ENST00000512883.1_Missense_Mutation_p.V272I|ARHGEF28_ENST00000513042.2_Missense_Mutation_p.V1352I	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		CGACTTGGCCGTCTCTGATGC	0.517000													11	10					0	0	1	0	0
TONSL	4796	broad.mit.edu	37	8	145667439	145667439	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:145667439G>C	ENST00000409379.3	-	7	875	c.846C>G	c.(844-846)atC>atG	p.I282M		NM_013432.4	NP_038460.4	Q96HA7	TONSL_HUMAN	tonsoku-like, DNA repair protein	282					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity			biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						GGTTCTGACAGATGGCTGCCC	0.652000													10	28					0	0	1	0	0
TBX2	6909	broad.mit.edu	37	17	59479191	59479191	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:59479191A>G	ENST00000240328.3	+	2	823	c.542A>G	c.(541-543)gAg>gGg	p.E181G	RP11-332H18.4_ENST00000592009.1_RNA	NM_005994.3	NP_005985.3	Q13207	TBX2_HUMAN	T-box 2	181					cell aging|positive regulation of cell proliferation		sequence-specific DNA binding			endometrium(1)|lung(7)|ovary(1)	9						GCCGACCCTGAGATGCCCAAA	0.577000													3	53					0	0	1	0	0
KIF18A	81930	broad.mit.edu	37	11	28113034	28113034	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:28113034G>C	ENST00000263181.6	-	4	800	c.510C>G	c.(508-510)ctC>ctG	p.L170L		NM_031217.3	NP_112494.3	Q8NI77	KI18A_HUMAN	kinesin family member 18A	170	Kinesin-motor.				blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	36						AATTTACTAAGAGATCACGAA	0.348000													34	101					0	0	1	0	0
CCDC113	29070	broad.mit.edu	37	16	58286671	58286671	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:58286671G>C	ENST00000219299.4	+	2	221	c.142G>C	c.(142-144)Gag>Cag	p.E48Q	CCDC113_ENST00000443128.2_Missense_Mutation_p.E48Q|CCDC113_ENST00000566498.1_3'UTR	NM_014157.3	NP_054876.2	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113	48						protein complex				large_intestine(4)|lung(6)|ovary(1)|urinary_tract(1)	12						TGAGATGTTTGAGAAATATTA	0.398000													12	80					0	0	1	0	0
TRAF3IP1	26146	broad.mit.edu	37	2	239242647	239242647	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:239242647C>T	ENST00000373327.4	+	7	1256	c.1034C>T	c.(1033-1035)tCa>tTa	p.S345L	TRAF3IP1_ENST00000391993.3_Missense_Mutation_p.S345L|TRAF3IP1_ENST00000391994.2_Missense_Mutation_p.S345L	NM_015650.3	NP_056465.2	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting protein 1	345	DISC1-interaction domain.					cytoplasm|cytoskeleton	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|skin(2)	23		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		ACAAAAACATCAAAACGGCGA	0.294000													21	51					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400429	40400429	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:40400429C>T	ENST00000338305.6	-	2	966	c.424G>A	c.(424-426)Gag>Aag	p.E142K		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	142						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					TCAAAAGCCTCATCTGCGATG	0.597000													13	29					0	0	1	0	0
RAI2	10742	broad.mit.edu	37	X	17819644	17819644	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:17819644C>T	ENST00000545871.1	-	3	947	c.487G>A	c.(487-489)Gag>Aag	p.E163K	RAI2_ENST00000331511.1_Missense_Mutation_p.E163K|RAI2_ENST00000451717.1_Missense_Mutation_p.E163K|RAI2_ENST00000360011.1_Missense_Mutation_p.E163K|RAI2_ENST00000415486.3_Missense_Mutation_p.E113K	NM_001172739.1|NM_001172743.1	NP_001166210|NP_001166214	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	163					embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					GGCTGGGCCTCGGGGTCCTCC	0.627000													20	55					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196887385	196887385	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:196887385A>T	ENST00000367416.2	+	10	1720	c.1583A>T	c.(1582-1584)cAg>cTg	p.Q528L	CFHR4_ENST00000608469.1_Missense_Mutation_p.Q152L|CFHR2_ENST00000367421.3_Intron|CFHR4_ENST00000251424.4_Missense_Mutation_p.Q282L|CFHR4_ENST00000367418.2_Missense_Mutation_p.Q282L	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4									p.Q528R(1)|p.Q282R(1)		NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						AATAACATACAGTTAAAAGGA	0.279000													8	72					0	0	1	0	0
SEPT4	5414	broad.mit.edu	37	17	56604309	56604309	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:56604309C>T	ENST00000426861.1	-	2	120	c.34G>A	c.(34-36)Gat>Aat	p.D12N	SEPT4_ENST00000579371.1_Intron|SEPT4_ENST00000317268.3_Missense_Mutation_p.D31N|SEPT4_ENST00000580844.1_Intron|RP11-112H10.4_ENST00000580769.1_RNA|RP11-112H10.4_ENST00000578022.1_RNA|SEPT4_ENST00000580791.1_5'UTR|RP11-112H10.4_ENST00000580589.1_RNA|SEPT4_ENST00000580809.1_Intron|SEPT4_ENST00000583114.1_5'UTR|SEPT4_ENST00000317256.6_Missense_Mutation_p.D12N|SEPT4_ENST00000412945.3_Missense_Mutation_p.D23N|SEPT4_ENST00000457347.2_Missense_Mutation_p.D46N|SEPT4_ENST00000393086.1_Missense_Mutation_p.D12N	NM_080415.2	NP_536340.1	O43236	SEPT4_HUMAN	septin 4	31					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	18	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGTTCTCCATCATCCGTGGTG	0.587000													34	67					0	0	1	0	0
SEMA4B	10509	broad.mit.edu	37	15	90771203	90771203	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:90771203C>G	ENST00000411539.2	+	14	2102	c.1842C>G	c.(1840-1842)ctC>ctG	p.L614L	SEMA4B_ENST00000379122.3_Silent_p.L609L|SEMA4B_ENST00000332496.6_Silent_p.L614L	NM_198925.2	NP_945119.1			sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B											NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)	12	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			GCCCGCTCCTCTCCAACCTGG	0.642000													11	26					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97869931	97869931	+	Missense_Mutation	SNP	A	A	T	rs76309140		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:97869931A>T	ENST00000420699.2	+	50	3236	c.2992A>T	c.(2992-2994)Aca>Tca	p.T998S	ANKRD36_ENST00000461153.2_Missense_Mutation_p.T998S	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	998								p.T998S(13)		endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						CATTCAGGCTACAAGTGATGA	0.289000													3	18					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181705515	181705515	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:181705515A>G	ENST00000526775.1	+	21	3475	c.3310A>G	c.(3310-3312)Aca>Gca	p.T1104A	CACNA1E_ENST00000367570.1_Missense_Mutation_p.T1123A|CACNA1E_ENST00000360108.3_Missense_Mutation_p.T1104A|CACNA1E_ENST00000367567.4_Missense_Mutation_p.T730A|CACNA1E_ENST00000367573.2_Missense_Mutation_p.T1123A|CACNA1E_ENST00000358338.5_Missense_Mutation_p.T1055A|CACNA1E_ENST00000357570.5_Missense_Mutation_p.T1074A	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1123					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						gaagCGTGAGACAGGCAAAGC	0.547000													11	16					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8100430	8100430	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:8100430C>T	ENST00000379328.3	+	3	972	c.404C>T	c.(403-405)cCg>cTg	p.P135L	GATA3_ENST00000346208.3_Missense_Mutation_p.P135L|GATA3_ENST00000461472.1_3'UTR	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	135					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						GTCTACCCCCCGGCCTCGTCC	0.721000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						17	30					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188170	152188170	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:152188170G>T	ENST00000368801.2	-	3	6010	c.5935C>A	c.(5935-5937)Cca>Aca	p.P1979T	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1979					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTCATATGGGCCACGGCTG	0.597000													69	550					6.01439e-56	6.4637e-56	1	1	0
ZFAND6	54469	broad.mit.edu	37	15	80414150	80414150	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:80414150C>T	ENST00000261749.6	+	4	673	c.251C>T	c.(250-252)tCt>tTt	p.S84F	ZFAND6_ENST00000561060.1_Missense_Mutation_p.S84F|ZFAND6_ENST00000558688.1_Missense_Mutation_p.S84F|ZFAND6_ENST00000559835.1_Missense_Mutation_p.S84F|ZFAND6_ENST00000558087.1_Missense_Mutation_p.S84F|ZFAND6_ENST00000558494.1_Missense_Mutation_p.S84F|ZFAND6_ENST00000559775.1_Missense_Mutation_p.S84F|ZFAND6_ENST00000559157.1_Missense_Mutation_p.S72F	NM_001242913.1|NM_001242914.1|NM_019006.3	NP_001229842.1|NP_001229843.1|NP_061879.2	Q6FIF0	ZFAN6_HUMAN	zinc finger, AN1-type domain 6	84	Ser-rich.						DNA binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11						ACATCTTCATCTATGCAGCCC	0.388000													7	21					0	0	1	0	0
PCDH12	51294	broad.mit.edu	37	5	141335988	141335988	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:141335988G>C	ENST00000231484.3	-	1	2639	c.1429C>G	c.(1429-1431)Ctt>Gtt	p.L477V		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	477	Cadherin 5.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGAGGTGAAGAGAGGGTAAG	0.463000													34	18					0	0	1	0	0
DNAJC10	54431	broad.mit.edu	37	2	183621176	183621176	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:183621176G>C	ENST00000264065.7	+	18	2204	c.1789G>C	c.(1789-1791)Gaa>Caa	p.E597Q		NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10		Thioredoxin 3.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CTTAATGCCAGAATGGAAAAG	0.348000													31	53					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28527520	28527520	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:28527520G>A	ENST00000337532.5	-	3	290	c.14C>T	c.(13-15)tCa>tTa	p.S5L	MPP7_ENST00000481244.1_5'UTR|MPP7_ENST00000540098.1_Missense_Mutation_p.S5L|MPP7_ENST00000445954.2_5'UTR|MPP7_ENST00000375732.1_Missense_Mutation_p.S5L|MPP7_ENST00000375719.3_Missense_Mutation_p.S5L	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	5					establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						AGATCCCGTTGACAAAGCTGG	0.512000													14	40					0	0	1	0	0
KIF18A	81930	broad.mit.edu	37	11	28119266	28119266	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:28119266C>G	ENST00000263181.6	-	2	519	c.229G>C	c.(229-231)Gat>Cat	p.D77H		NM_031217.3	NP_112494.3	Q8NI77	KI18A_HUMAN	kinesin family member 18A	77	Kinesin-motor.				blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	36						AAAACAGCATCAAATACAAAT	0.299000													10	43					0	0	1	0	0
C9orf69	90120	broad.mit.edu	37	9	139008402	139008402	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:139008402G>A	ENST00000418388.1	-	2	847	c.345C>T	c.(343-345)ctC>ctT	p.L115L	C9orf69_ENST00000561457.1_3'UTR					chromosome 9 open reading frame 69											endometrium(1)	1		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.58e-07)|Epithelial(140;6.42e-06)		TGCCATAGACGAGCAGCTCGT	0.657000													12	9					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63947995	63947995	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:63947995C>G	ENST00000443617.2	-	50	10117	c.10030G>C	c.(10030-10032)Gac>Cac	p.D3344H		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	3344					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GCCCCTTTGTCTGCTAGCAAT	0.413000													5	4					0	0	1	0	0
NR1H4	9971	broad.mit.edu	37	12	100904639	100904639	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:100904639C>T	ENST00000548884.1	+	4	704	c.163C>T	c.(163-165)Ccc>Tcc	p.P55S	NR1H4_ENST00000188403.7_Missense_Mutation_p.P65S|NR1H4_ENST00000549996.1_Missense_Mutation_p.P55S|NR1H4_ENST00000551379.1_Missense_Mutation_p.P65S|NR1H4_ENST00000392986.3_Missense_Mutation_p.P55S	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	65					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						TGTTCAGTTTCCCCAAGTTCA	0.458000													7	55					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61034981	61034981	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:61034981C>T	ENST00000335613.5	-	16	2304	c.1918G>A	c.(1918-1920)Gag>Aag	p.E640K	VWCE_ENST00000535710.1_Missense_Mutation_p.E105K	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	640	VWFC 5.					extracellular region	calcium ion binding	p.E640K(1)		biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						GGGAAGGTCTCGTTGTTATAG	0.607000													14	41					0	0	1	0	0
BBS2	583	broad.mit.edu	37	16	56531756	56531756	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:56531756C>T	ENST00000245157.5	-	14	2116	c.1696G>A	c.(1696-1698)Gat>Aat	p.D566N	BBS2_ENST00000568104.1_Intron	NM_031885.3	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2	566					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)	26						TGGATGATATCACCAGCCAAA	0.348000									Bardet-Biedl syndrome				35	49					0	0	1	0	0
RSRC1	51319	broad.mit.edu	37	3	157839929	157839929	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:157839929C>T	ENST00000464171.1	+	2	161	c.36C>T	c.(34-36)agC>agT	p.S12S	RSRC1_ENST00000312179.6_Silent_p.S12S|RSRC1_ENST00000475278.2_Silent_p.S12S|RSRC1_ENST00000480820.1_Silent_p.S12S|RSRC1_ENST00000295930.3_Silent_p.S12S	NM_001271834.1	NP_001258763.1	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	12	Arg/Ser-rich.				nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|upper_aerodigestive_tract(1)	18			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			AAGAAGAAAGCAGAAGCAAGA	0.388000													5	32					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18737214	18737214	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:18737214C>G	ENST00000513874.1	-	11	1435	c.1296G>C	c.(1294-1296)gaG>gaC	p.E432D	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	432	Ig-like 3.							p.E432D(2)		NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						CGCGACTCCTCTCTTTCACAC	0.517000													31	58					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138793963	138793963	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:138793963C>T	ENST00000242351.5	-	1	431	c.115G>A	c.(115-117)Gag>Aag	p.E39K	ZC3HAV1_ENST00000471652.1_Missense_Mutation_p.E39K|ZC3HAV1_ENST00000464606.1_Missense_Mutation_p.E39K	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	39					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						TGCAGCACCTCACAGAGCTGC	0.692000													6	7					0	0	1	0	0
IGF2BP3	10643	broad.mit.edu	37	7	23509577	23509577	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:23509577G>C	ENST00000258729.3	-	1	509	c.153C>G	c.(151-153)ctC>ctG	p.L51L		NM_006547.2	NP_006538.2	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding protein 3	51	RRM 1.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(2)|prostate(2)|skin(4)|stomach(1)	34						CGATGGCCTTGAGGGCCCAGC	0.697000													7	37					0	0	1	0	0
AAMP	14	broad.mit.edu	37	2	219131678	219131678	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:219131678G>A	ENST00000248450.4	-	4	596	c.426C>T	c.(424-426)ttC>ttT	p.F142F	AAMP_ENST00000420660.1_Silent_p.F123F|AAMP_ENST00000444053.1_Silent_p.F143F			Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	142					angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(4)|ovary(2)|skin(1)	11		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGTCATGGCTGAAACCAGCAC	0.512000													11	57					0	0	1	0	0
MCPH1	79648	broad.mit.edu	37	8	6500547	6500547	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:6500547G>C	ENST00000344683.5	+	14	2561	c.2485G>C	c.(2485-2487)Gaa>Caa	p.E829Q	CTD-2541M15.1_ENST00000527490.1_RNA|CTD-2541M15.1_ENST00000515608.1_RNA|MCPH1_ENST00000521175.1_3'UTR|CTD-2541M15.1_ENST00000522897.1_RNA|CTD-2541M15.1_ENST00000525186.1_RNA	NM_024596.3	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin 1	829	BRCT 3.					microtubule organizing center			AGPAT5/MCPH1(2)	central_nervous_system(1)|large_intestine(4)|skin(1)	6		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		CTGTGCCCCTGAAAACTACCT	0.448000													3	28					0	0	1	0	0
GSAP	54103	broad.mit.edu	37	7	76982337	76982337	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:76982337G>T	ENST00000257626.7	-	18	1493	c.1415C>A	c.(1414-1416)tCa>tAa	p.S472*		NM_017439.3	NP_059135.2			gamma-secretase activating protein																		ACTCCAGTATGAAGAAGCTGA	0.373000													38	82					2.54651e-27	2.72511e-27	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414379	20414379	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:20414379G>A	ENST00000380338.4	-	5	751	c.465C>T	c.(463-465)agC>agT	p.S155S	MLLT3_ENST00000429426.2_Silent_p.S152S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	155	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S155S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.532000			T	MLL	ALL								5	83					0	0	1	0	0
IMP4	92856	broad.mit.edu	37	2	131102277	131102277	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:131102277G>C	ENST00000259239.3	+	3	896	c.188G>C	c.(187-189)gGa>gCa	p.G63A	IMP4_ENST00000409935.1_Missense_Mutation_p.G63A	NM_033416.1	NP_219484.1	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)	63					rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding	p.G63V(1)		central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	18	Colorectal(110;0.1)					GATGATGCTGGAGGTGAAGGT	0.567000													10	37					0	0	1	0	0
ARPC4	10093	broad.mit.edu	37	3	9845538	9845538	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:9845538C>G	ENST00000397261.3	+	5	906	c.342C>G	c.(340-342)atC>atG	p.I114M	ARPC4_ENST00000433034.1_Missense_Mutation_p.I133M|ARPC4_ENST00000498623.2_Missense_Mutation_p.I24M|ARPC4_ENST00000287613.7_Missense_Mutation_p.I24M|ARPC4-TTLL3_ENST00000397256.1_Intron	NM_005718.4	NP_005709.1			actin related protein 2/3 complex, subunit 4, 20kDa											breast(1)|lung(1)	2	Medulloblastoma(99;0.227)					GGTATGATATCAGCTTTCTGA	0.488000													51	101					0	0	1	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50685414	50685414	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:50685414C>G	ENST00000446044.1	+	13	1682	c.1086C>G	c.(1084-1086)ctC>ctG	p.L362L	MAPKAPK3_ENST00000357955.2_Silent_p.L362L	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	362					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		ACCGGCTCCTCAACAAGAGGA	0.577000													17	41					0	0	1	0	0
CERS5	91012	broad.mit.edu	37	12	50524372	50524372	+	Missense_Mutation	SNP	G	G	A	rs147527651		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:50524372G>A	ENST00000317551.6	-	10	1259	c.1135C>T	c.(1135-1137)Cgg>Tgg	p.R379W	CERS5_ENST00000422340.2_Missense_Mutation_p.R321W	NM_147190.2	NP_671723.1	Q8N5B7	CERS5_HUMAN	ceramide synthase 5	379					ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CCATTCACCCGATTGGCACCA	0.522000													34	64					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121435584	121435584	+	Splice_Site	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:121435584C>A	ENST00000393667.3	-	9	1398	c.1288G>T	c.(1288-1290)Gat>Tat	p.D430Y	GOLGB1_ENST00000340645.5_Splice_Site_p.D425Y	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	425					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		AGCTACTGACCTTCCAGTTGC	0.418000													29	71					2.81731e-10	2.93993e-10	1	1	0
PPFIBP2	8495	broad.mit.edu	37	11	7661079	7661079	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:7661079G>A	ENST00000299492.4	+	15	1741	c.1353G>A	c.(1351-1353)acG>acA	p.T451T	PPFIBP2_ENST00000528883.1_Silent_p.T339T|PPFIBP2_ENST00000533792.1_Silent_p.T293T|PPFIBP2_ENST00000530181.1_Silent_p.T308T|PPFIBP2_ENST00000530582.1_3'UTR	NM_003621.3	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	451					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CTGACGCCACGGGGAGCAGCC	0.577000													28	36					0	0	1	0	0
NOC2L	26155	broad.mit.edu	37	1	881822	881822	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:881822C>T	ENST00000327044.6	-	15	1812	c.1763G>A	c.(1762-1764)cGc>cAc	p.R588H		NM_015658.3	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog (S. cerevisiae)	588						nucleolus	protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	16	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		AACCCTCTGGCGGCGGCTGCA	0.627000													12	56					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900569	51900569	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:51900569G>T	ENST00000268919.4	+	1	331	c.175G>T	c.(175-177)Gag>Tag	p.E59*		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	59					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GGTCACGGTAGAGTGGGTGGA	0.542000													28	65					1.06801e-11	1.12147e-11	1	1	0
NKX2-3	159296	broad.mit.edu	37	10	101294995	101294995	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:101294995G>C	ENST00000344586.7	+	2	811	c.612G>C	c.(610-612)aaG>aaC	p.K204N		NM_145285.2	NP_660328.2	Q8TAU0	NKX23_HUMAN	NK2 homeobox 3	204						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	5		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.45e-08)		ACAAGTGCAAGAGACAGCGGC	0.667000													5	7					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55968538	55968538	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:55968538C>G	ENST00000263923.4	-	14	2420	c.2125G>C	c.(2125-2127)Gaa>Caa	p.E709Q		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	709	Ig-like C2-type 7.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CCTGAGTCTTCTACAAGGGTC	0.413000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			42	49					0	0	1	0	0
OXCT1	5019	broad.mit.edu	37	5	41794150	41794150	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:41794150C>G	ENST00000196371.5	-	13	1363	c.1203G>C	c.(1201-1203)gcG>gcC	p.A401A	OXCT1_ENST00000513081.1_5'UTR|OXCT1_ENST00000512084.1_Silent_p.A4A|OXCT1_ENST00000509987.1_Silent_p.A215A|OXCT1_ENST00000510634.1_Silent_p.A4A	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	401					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	AAACCTGCATCGCTCCTAGCA	0.383000													51	168					0	0	1	0	0
USP45	85015	broad.mit.edu	37	6	99894213	99894213	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:99894213C>T	ENST00000327681.6	-	14	1967	c.1435G>A	c.(1435-1437)Gag>Aag	p.E479K	USP45_ENST00000369233.2_Missense_Mutation_p.E431K|USP45_ENST00000392738.2_Missense_Mutation_p.E159K|USP45_ENST00000539675.1_Intron|USP45_ENST00000500704.2_Missense_Mutation_p.E479K	NM_001080481.1	NP_001073950.1	Q70EL2	UBP45_HUMAN	ubiquitin specific peptidase 45	479					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(2)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	22		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)		AGACGTGACTCAGAATTCATG	0.393000													31	43					0	0	1	0	0
ATL3	25923	broad.mit.edu	37	11	63400560	63400560	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:63400560C>T	ENST00000398868.3	-	11	1321	c.1045G>A	c.(1045-1047)Gaa>Aaa	p.E349K	ATL3_ENST00000332645.4_Missense_Mutation_p.E376K|ATL3_ENST00000538786.1_Missense_Mutation_p.E331K	NM_015459.3	NP_056274.3	Q6DD88	ATLA3_HUMAN	atlastin GTPase 3	349					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	11						TTGTTGGCTTCAGCAGTGGCC	0.388000													22	44					0	0	1	0	0
ELMSAN1	91748	broad.mit.edu	37	14	74186066	74186066	+	Missense_Mutation	SNP	C	C	G	rs144598731		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:74186066C>G	ENST00000286523.5	-	12	3858	c.3076G>C	c.(3076-3078)Gag>Cag	p.E1026Q	ELMSAN1_ENST00000394071.2_Missense_Mutation_p.E1026Q	NM_194278.3	NP_919254.2			ELM2 and Myb/SANT-like domain containing 1																		CTGAATGTCTCTGTTTTTTTC	0.572000													13	26					0	0	1	0	0
STRIP1	85369	broad.mit.edu	37	1	110593664	110593664	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:110593664G>A	ENST00000369795.3	+	19	2065	c.2043G>A	c.(2041-2043)tgG>tgA	p.W681*	STRIP1_ENST00000369796.1_Nonsense_Mutation_p.W586*	NM_033088.3	NP_149079.2			striatin interacting protein 1																		TGACAAAGTGGAAGCATTCAA	0.498000													10	30					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69673486	69673486	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:69673486G>A	ENST00000194900.4	+	9	1540		c.e9-1		DLG3-AS1_ENST00000424211.1_RNA|DLG3_ENST00000374360.3_Splice_Site|DLG3-AS1_ENST00000431103.1_RNA|DLG3_ENST00000374355.3_Splice_Site			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)						axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					TTTCCCACCAGAGAGCCTCGC	0.527000													9	14					0	0	1	0	0
DNAJC11	55735	broad.mit.edu	37	1	6741080	6741080	+	Silent	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:6741080C>A	ENST00000377577.5	-	2	213	c.90G>T	c.(88-90)ctG>ctT	p.L30L	DNAJC11_ENST00000542246.1_5'UTR|DNAJC11_ENST00000349363.6_5'UTR|DNAJC11_ENST00000294401.7_Silent_p.L30L|DNAJC11_ENST00000377573.5_5'UTR	NM_018198.3	NP_060668.2	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	30	J.				protein folding		heat shock protein binding|unfolded protein binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)|urinary_tract(1)	32	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		AGGCAGCTTTCAGCTCTTCAG	0.443000													28	51					1.68575e-08	1.73574e-08	1	1	0
ACTR1A	10121	broad.mit.edu	37	10	104241919	104241919	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:104241919C>T	ENST00000369905.4	-	8	827	c.764G>A	c.(763-765)cGa>cAa	p.R255Q	ACTR1A_ENST00000487599.1_Missense_Mutation_p.R255Q|ACTR1A_ENST00000470322.1_5'UTR|ACTR1A_ENST00000446605.2_Missense_Mutation_p.R208Q|ACTR1A_ENST00000545684.1_Missense_Mutation_p.R181Q	NM_005736.3	NP_005727.1	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	255					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	13		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		GGCCCGGAATCGGGAAGGACC	0.582000													15	65					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33604915	33604915	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:33604915G>A	ENST00000321505.4	+	10	3723	c.3543G>A	c.(3541-3543)tgG>tgA	p.W1181*	KIAA1549L_ENST00000265654.5_Nonsense_Mutation_p.W1187*|KIAA1549L_ENST00000389726.3_Nonsense_Mutation_p.W1187*					KIAA1549-like																		ATAACCTGTGGATCATCGCTG	0.547000													3	7					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153056624	153056624	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:153056624G>A	ENST00000285900.5	+	7	1275	c.932G>A	c.(931-933)aGa>aAa	p.R311K	GRIA1_ENST00000521843.2_Missense_Mutation_p.R242K|GRIA1_ENST00000518783.1_Missense_Mutation_p.R321K|GRIA1_ENST00000448073.4_Missense_Mutation_p.R321K|GRIA1_ENST00000518142.1_Missense_Mutation_p.R231K|GRIA1_ENST00000340592.5_Missense_Mutation_p.R311K	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	311					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CGGAGGCAGAGAATTGATATA	0.562000													18	11					0	0	1	0	0
CSPP1	79848	broad.mit.edu	37	8	68007756	68007756	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:68007756G>A	ENST00000262210.5	+	6	770	c.739G>A	c.(739-741)Gaa>Aaa	p.E247K	CSPP1_ENST00000412460.1_5'UTR	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	282						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AGCAAATGAAGAAGTGGGCAT	0.368000													16	45					0	0	1	0	0
CDKN1A	1026	broad.mit.edu	37	6	36652021	36652021	+	Missense_Mutation	SNP	G	G	C	rs12721594		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:36652021G>C	ENST00000405375.1	+	2	378	c.143G>C	c.(142-144)cGa>cCa	p.R48P	CDKN1A_ENST00000448526.2_Missense_Mutation_p.R82P|CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000373711.2_Missense_Mutation_p.R48P|CDKN1A_ENST00000244741.5_Missense_Mutation_p.R48P	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	48					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						GCCCGTGAGCGATGGAACTTC	0.662000													9	20					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26969903	26969903	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:26969903C>G	ENST00000528896.2	-	5	573	c.499G>C	c.(499-501)Gat>Cat	p.D167H	KIAA0100_ENST00000544884.1_Missense_Mutation_p.D24H|KIAA0100_ENST00000389003.3_Missense_Mutation_p.D24H	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	167						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					CCATCACTATCCAAAAGAAAT	0.438000													20	45					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16989123	16989123	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:16989123C>G	ENST00000379803.1	+	19	3194	c.3180C>G	c.(3178-3180)ctC>ctG	p.L1060L	SIN3B_ENST00000595541.1_Silent_p.L618L|SIN3B_ENST00000248054.5_Silent_p.L1028L|SIN3B_ENST00000594235.1_3'UTR	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	1060					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						GCTTCAAGCTCAGCACTCACA	0.677000													4	13					0	0	1	0	0
SLC47A1	55244	broad.mit.edu	37	17	19458572	19458572	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:19458572C>T	ENST00000270570.4	+	7	677	c.591C>T	c.(589-591)gtC>gtT	p.V197V	SLC47A1_ENST00000584348.1_3'UTR|SLC47A1_ENST00000436810.2_Silent_p.V174V|SLC47A1_ENST00000395585.1_Silent_p.V197V|SLC47A1_ENST00000457293.1_Silent_p.V197V|SLC47A1_ENST00000571335.1_Intron|SLC47A1_ENST00000542886.1_Intron|SLC47A1_ENST00000575023.1_Intron	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	197						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					CCAACCTTGTCAATGCCCTCG	0.507000													64	84					0	0	1	0	0
C9orf66	157983	broad.mit.edu	37	9	215012	215012	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:215012C>T	ENST00000382387.2	-	1	881	c.385G>A	c.(385-387)Gaa>Aaa	p.E129K	DOCK8_ENST00000453981.1_Silent_p.F12F|DOCK8_ENST00000432829.2_5'UTR	NM_152569.2	NP_689782.2	Q5T8R8	CI066_HUMAN	chromosome 9 open reading frame 66	129										central_nervous_system(1)|cervix(1)|kidney(1)|skin(1)	4	all_lung(41;0.218)	all_cancers(5;2.09e-12)|all_epithelial(5;6.16e-09)|all_lung(10;1.15e-08)|Lung NSC(10;1.91e-08)|Acute lymphoblastic leukemia(5;0.00457)|all_hematologic(5;0.0332)|Breast(48;0.0646)|Prostate(43;0.137)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCCGCGCGTTCGCGCTCAAGA	0.741000													4	10					0	0	1	0	0
ATF6B	1388	broad.mit.edu	37	6	32089082	32089082	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:32089082G>C	ENST00000375201.4	-	6	558	c.513C>G	c.(511-513)gtC>gtG	p.V171V	ATF6B_ENST00000375203.3_Silent_p.V174V			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	174					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						CCTCAGAGTTGACGGAAGAAC	0.527000													5	12					0	0	1	0	0
NUGGC	389643	broad.mit.edu	37	8	27918005	27918005	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:27918005G>C	ENST00000413272.2	-	8	1177	c.1035C>G	c.(1033-1035)ttC>ttG	p.F345L	NUGGC_ENST00000341513.6_Missense_Mutation_p.F345L	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		CGTCCCTACAGAAGCCCCGCT	0.557000											OREG0018675	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	15					0	0	1	0	0
TNFAIP8L2	79626	broad.mit.edu	37	1	151131665	151131665	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:151131665C>T	ENST00000368910.3	+	2	618	c.492C>T	c.(490-492)ttC>ttT	p.F164F		NM_024575.4	NP_078851.2	Q6P589	TP8L2_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 2	164					innate immune response					lung(1)|skin(2)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGCCTGACTTCACTCAGCACC	0.562000													10	51					0	0	1	0	0
XRCC4	7518	broad.mit.edu	37	5	82500738	82500738	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:82500738C>T	ENST00000282268.3	+	6	918	c.743C>T	c.(742-744)tCa>tTa	p.S248L	XRCC4_ENST00000509268.1_3'UTR|XRCC4_ENST00000511817.1_Missense_Mutation_p.S248L|XRCC4_ENST00000396027.4_Missense_Mutation_p.S248L|XRCC4_ENST00000338635.6_Missense_Mutation_p.S248L	NM_003401.3|NM_022406.2|NM_022550.2	NP_003392.1|NP_071801.1|NP_072044.1	Q13426	XRCC4_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 4	248					DNA ligation involved in DNA repair|double-strand break repair via nonhomologous end joining|initiation of viral infection|positive regulation of ligase activity|provirus integration|response to X-ray	cytosol|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|nucleoplasm	DNA binding|protein C-terminus binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(2)|skin(3)	17		Lung NSC(167;0.00132)|all_lung(232;0.00154)|Ovarian(174;0.034)		OV - Ovarian serous cystadenocarcinoma(54;1.44e-38)|Epithelial(54;3.72e-33)|all cancers(79;9.22e-28)		GGGTTGGCTTCAGGTAAGAGA	0.383000								Non-homologous end-joining					11	11					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6697466	6697466	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:6697466G>C	ENST00000309577.6	-	23	3626	c.3463C>G	c.(3463-3465)Cag>Gag	p.Q1155E	CHD4_ENST00000544040.1_Missense_Mutation_p.Q1148E|CHD4_ENST00000357008.2_Missense_Mutation_p.Q1155E|CHD4_ENST00000544484.1_Missense_Mutation_p.Q1152E			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1155	Helicase C-terminal.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CTGCTCACCTGAATGTCATTA	0.473000													25	67					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78073383	78073383	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:78073383G>C	ENST00000397545.4	+	20	3265	c.3238G>C	c.(3238-3240)Gag>Cag	p.E1080Q		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1080					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GGCTGTGAAGGAGGGGCGCTA	0.587000													17	46					0	0	1	0	0
C11orf57	55216	broad.mit.edu	37	11	111946328	111946328	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:111946328C>G	ENST00000280352.9	+	2	666	c.30C>G	c.(28-30)ctC>ctG	p.L10L	C11orf57_ENST00000530104.1_Silent_p.L10L|C11orf57_ENST00000532163.1_5'UTR|C11orf57_ENST00000420986.2_Silent_p.L10L|C11orf57_ENST00000393047.3_Silent_p.L10L	NM_001082970.1|NM_018195.3	NP_001076439.1|NP_060665.3	Q6ZUT1	CK057_HUMAN	chromosome 11 open reading frame 57	10										autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	12		all_cancers(61;9.8e-15)|all_epithelial(67;6.57e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.6e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;7.01e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0521)		GGAAGGTCCTCCTGAGGAATG	0.418000													7	11					0	0	1	0	0
ALYREF	10189	broad.mit.edu	37	17	79847195	79847195	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:79847195G>T	ENST00000331204.4	-	3	406	c.380C>A	c.(379-381)gCt>gAt	p.A127D	ALYREF_ENST00000512673.1_5'UTR|ALYREF_ENST00000505490.2_Missense_Mutation_p.A134D	NM_005782.3	NP_005773.3	Q86V81	THOC4_HUMAN	Aly/REF export factor	127	Ala/Arg/Gly-rich.|RRM.				intronless viral mRNA export from host nucleus|mRNA 3'-end processing|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear speck|transcription export complex	nucleotide binding|protein binding|RNA binding										TCCAAATTCAGCAAAGAGTTC	0.547000													9	76					3.09899e-07	3.17142e-07	1	1	0
SON	6651	broad.mit.edu	37	21	34932413	34932413	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr21:34932413C>G	ENST00000300278.4	+	7	6917	c.6888C>G	c.(6886-6888)ctC>ctG	p.L2296L	SON_ENST00000356577.4_Intron|SON_ENST00000381692.2_Intron|SON_ENST00000290239.6_Intron	NM_032195.1	NP_115571	P18583	SON_HUMAN	SON DNA binding protein	0					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						CTTCAAGGCTCTATAGCTCTA	0.473000													18	91					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156641378	156641378	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:156641378G>C	ENST00000368223.3	-	4	2734	c.2602C>G	c.(2602-2604)Caa>Gaa	p.Q868E		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	868	Tail.			QGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGA WNLENLRSPEE -> KSGGNESSRKGNSRTTGVCGSEPRDI QTPGRGESGIIEISGSMEPGEFEISRG (in Ref. 1; CAA46780).	brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGTGGTTCTTGAATTTCCTTT	0.453000													32	179					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5154277	5154277	+	Missense_Mutation	SNP	G	G	A	rs139614200	by1000genomes	TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:5154277G>A	ENST00000252321.3	+	1	1193	c.964G>A	c.(964-966)Gac>Aac	p.D322N		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	322						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						GACCCTGGCCGACCCCTTCTT	0.701000													16	36					0	0	1	0	0
CDA	978	broad.mit.edu	37	1	20945011	20945011	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:20945011G>T	ENST00000375071.3	+	4	573	c.391G>T	c.(391-393)Gag>Tag	p.E131*	CDA_ENST00000461985.1_3'UTR	NM_001785.2	NP_001776.1	P32320	CDD_HUMAN	cytidine deaminase	131					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	GACGGTCCAGGAGCTGCTGCC	0.552000													6	20					2.0095e-06	2.05022e-06	1	1	0
ITSN2	50618	broad.mit.edu	37	2	24521593	24521593	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:24521593C>A	ENST00000355123.4	-	13	1878	c.1435G>T	c.(1435-1437)Gaa>Taa	p.E479*	ITSN2_ENST00000406921.3_Nonsense_Mutation_p.E479*|ITSN2_ENST00000361999.3_Nonsense_Mutation_p.E479*	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	479					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAATTTCTTCTTGTTCTCTA	0.378000													41	77					5.20837e-25	5.56185e-25	1	1	0
OR4X2	119764	broad.mit.edu	37	11	48267115	48267115	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:48267115C>T	ENST00000302329.3	+	1	508	c.460C>T	c.(460-462)Ctc>Ttc	p.L154F		NM_001004727.1	NP_001004727.1	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X, member 2	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(4)|lung(12)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	20						ACAAATCCTTCTCATCTTCCA	0.498000													54	117					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168108151	168108151	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:168108151G>A	ENST00000409195.1	+	9	10338	c.10249G>A	c.(10249-10251)Gaa>Aaa	p.E3417K	XIRP2_ENST00000409273.1_Missense_Mutation_p.E3195K|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E3417K|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3242					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GTCTCTAAGTGAACATTTCTC	0.433000													32	60					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	62940941	62940941	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:62940941G>C	ENST00000251157.5	-	46	6043	c.6010C>G	c.(6010-6012)Ccc>Gcc	p.P2004A	DOCK7_ENST00000340370.5_Missense_Mutation_p.P1984A|DOCK7_ENST00000489185.1_5'UTR	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	2015	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						GGGTCTGCGGGATCCTGATGT	0.443000													19	32					0	0	1	0	0
CALR	811	broad.mit.edu	37	19	13051099	13051099	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:13051099G>C	ENST00000316448.5	+	5	608	c.535G>C	c.(535-537)Gac>Cac	p.D179H		NM_004343.3	NP_004334.1	P27797	CALR_HUMAN	calreticulin	179	N-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(1)	10					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGTGCGGCCAGACAACACCTA	0.527000													49	24					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767646	105767646	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:105767646G>A	ENST00000374798.3	+	5	803	c.733G>A	c.(733-735)Gag>Aag	p.E245K	CYLC2_ENST00000487798.1_Missense_Mutation_p.E245K	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	245	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton	p.E245*(2)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				AAAGAAGGATGAGGATGGAAA	0.368000													13	52					0	0	1	0	0
ID1	3397	broad.mit.edu	37	20	30193552	30193552	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:30193552G>C	ENST00000376105.3	+	1	461	c.362G>C	c.(361-363)cGa>cCa	p.R121P	ID1_ENST00000376112.3_Missense_Mutation_p.R121P	NM_181353.2	NP_851998.1	P41134	ID1_HUMAN	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	121					angiogenesis|blood vessel endothelial cell migration|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by transcription factor localization|transforming growth factor beta receptor signaling pathway	cytoplasm	protein binding			endometrium(2)|ovary(1)|pancreas(1)	4	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.99e-05)|all cancers(5;0.000169)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			CCCGGGGGCCGAGGGCTGCCG	0.602000													8	6					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95189879	95189879	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:95189879C>A	ENST00000027335.3	-	4	345	c.221G>T	c.(220-222)cGg>cTg	p.R74L	CDH17_ENST00000441892.2_Missense_Mutation_p.R74L|CDH17_ENST00000450165.2_Missense_Mutation_p.R74L	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	74	Cadherin 1.					integral to membrane	calcium ion binding	p.R74L(1)		NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			AAGTCCCTCCCGTTCTATCAC	0.423000													14	38					4.36969e-10	4.53637e-10	1	1	0
KCNAB1	7881	broad.mit.edu	37	3	155838448	155838448	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:155838448G>A	ENST00000490337.1	+	1	112	c.48G>A	c.(46-48)gaG>gaA	p.E16E	KCNAB1_ENST00000389636.5_Silent_p.E16E	NM_172160.2	NP_751892.1	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	16						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TCTCAGAGGAGAACACCAAGT	0.498000													47	105					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155219599	155219599	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:155219599G>A	ENST00000357232.4	-	18	4501	c.4502C>T	c.(4501-4503)tCa>tTa	p.S1501L		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 13.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GTCCACAGCTGAAAGCACAAG	0.463000													15	70					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29102124	29102124	+	RNA	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:29102124C>G	ENST00000564580.1	+	0	715																											GCATGAAATTCTGGAGCTTAT	0.259000													5	52					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8872079	8872079	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:8872079G>A	ENST00000256707.3	-	30	4268	c.4087C>T	c.(4087-4089)Ctc>Ttc	p.L1363F	KIDINS220_ENST00000418530.1_Missense_Mutation_p.L1264F|KIDINS220_ENST00000427284.1_Missense_Mutation_p.L1344F|KIDINS220_ENST00000473731.1_Missense_Mutation_p.L1344F	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1363					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TGGGAATTGAGACTCGAAAGA	0.368000													37	64					0	0	1	0	0
SLC16A2	6567	broad.mit.edu	37	X	73641814	73641814	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:73641814C>G	ENST00000276033.5	+	1	730	c.564C>G	c.(562-564)atC>atG	p.I188M	SLC16A2_ENST00000587091.1_Missense_Mutation_p.I114M			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	114						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	ACGGCTCCATCTTCGGCATCC	0.607000													6	16					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117119145	117119145	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:117119145G>C	ENST00000307564.4	-	13	3005	c.2844C>G	c.(2842-2844)atC>atG	p.I948M	AKNA_ENST00000374075.5_Missense_Mutation_p.I867M|AKNA_ENST00000223791.3_Missense_Mutation_p.I408M|AKNA_ENST00000374088.3_Missense_Mutation_p.I948M	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	948					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						CGGGATACCTGATGTGGGAGA	0.587000													44	50					0	0	1	0	0
PROSER2	254427	broad.mit.edu	37	10	11908560	11908560	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:11908560G>A	ENST00000277570.5	+	3	323	c.169G>A	c.(169-171)Gag>Aag	p.E57K	PROSER2_ENST00000474155.1_3'UTR|PROSER2-AS1_ENST00000453242.1_RNA|PROSER2-AS1_ENST00000445498.1_RNA	NM_153256.3	NP_694988.3			proline and serine-rich protein 2																		CCTCACCCATGAGGAAAAGGA	0.483000													61	114					0	0	1	0	0
ABLIM3	22885	broad.mit.edu	37	5	148632322	148632322	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:148632322C>G	ENST00000506113.1	+	22	2342	c.1860C>G	c.(1858-1860)atC>atG	p.I620M	ABLIM3_ENST00000508983.1_Missense_Mutation_p.I587M|ABLIM3_ENST00000504238.1_Missense_Mutation_p.I509M|ABLIM3_ENST00000517451.1_Missense_Mutation_p.I106M|ABLIM3_ENST00000356541.3_Missense_Mutation_p.I509M|AC012613.2_ENST00000523176.1_RNA|RP11-331K21.1_ENST00000512647.2_RNA|ABLIM3_ENST00000326685.7_Missense_Mutation_p.I525M|ABLIM3_ENST00000309868.7_Missense_Mutation_p.I620M|RP11-331K21.1_ENST00000522685.1_RNA			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	620	HP.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCTTAGATCTACCCTTATG	0.493000													27	36					0	0	1	0	0
RTP1	132112	broad.mit.edu	37	3	186915459	186915459	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:186915459G>C	ENST00000312295.4	+	1	186	c.156G>C	c.(154-156)gaG>gaC	p.E52D	RP11-208N14.4_ENST00000356133.3_RNA	NM_153708.2	NP_714919.2	P59025	RTP1_HUMAN	receptor (chemosensory) transporter protein 1	52					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		TCTTCTATGAGAAGATGGAGG	0.507000													22	53					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19347005	19347005	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:19347005G>C	ENST00000263208.5	-	18	2344	c.2088C>G	c.(2086-2088)gtC>gtG	p.V696V	HIRA_ENST00000546308.1_Silent_p.V652V|HIRA_ENST00000340170.4_Intron|HIRA_ENST00000541063.1_Silent_p.V652V	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	696	Interaction with CCNA1.|Interaction with PAX3 (By similarity).|Interaction with histone H2B.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					GATCGGAGCTGACCTGGATGA	0.597000													5	10					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51776682	51776682	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:51776682G>C	ENST00000371117.3	-	39	6680	c.6405C>G	c.(6403-6405)ctC>ctG	p.L2135L	PKHD1_ENST00000340994.4_Silent_p.L2135L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2135					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					TACTCCTGCTGAGCAGAGCCA	0.438000													19	64					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59210975	59210975	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:59210975C>A	ENST00000302030.2	+	1	359	c.334C>A	c.(334-336)Ctg>Atg	p.L112M		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						CGGCATGGGTCTGTCTGAGTG	0.527000													54	143					2.01807e-28	2.16191e-28	1	1	0
RORA	6095	broad.mit.edu	37	15	60970881	60970881	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:60970881G>C	ENST00000335670.6	-	2	271	c.171C>G	c.(169-171)atC>atG	p.I57M	RORA_ENST00000560004.1_5'UTR	NM_134261.2	NP_599023.1	P35398	RORA_HUMAN	RAR-related orphan receptor A	0	Modulating.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	21						TCGTTACTGAGATACCTGGAA	0.423000													8	35					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125686427	125686427	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:125686427C>G	ENST00000371126.1	-	1	407	c.165G>C	c.(163-165)ctG>ctC	p.L55L		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	55										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						CCCGAACCTTCAGATAGTGCG	0.711000													25	55					0	0	1	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281647	49281647	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:49281647G>A	ENST00000282018.3	+	1	697	c.694G>A	c.(694-696)Gag>Aag	p.E232K		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	232					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	GTTAAAAGTGGAGGTCCCAGA	0.498000													16	63					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9266109	9266109	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:9266109G>C	ENST00000318602.7	-	2	424	c.117C>G	c.(115-117)ctC>ctG	p.L39L		NM_000014.4	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin	39					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	TCTCAGTGTGGAGCAGGGAGG	0.507000													31	38					0	0	1	0	0
CRELD2	79174	broad.mit.edu	37	22	50319169	50319169	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:50319169G>A	ENST00000404488.3	+	10	1255	c.1120G>A	c.(1120-1122)Gaa>Aaa	p.E374K	CRELD2_ENST00000403427.3_Missense_Mutation_p.E297K|CRELD2_ENST00000328268.4_Missense_Mutation_p.E325K|CRELD2_ENST00000407217.3_Missense_Mutation_p.E293K	NM_001135101.1	NP_001128573.1	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2	325						endoplasmic reticulum|extracellular region	calcium ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|stomach(3)	9		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		CGGCTTCGAAGAAACGGAAGA	0.587000													20	39					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80890567	80890567	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:80890567C>T	ENST00000355528.4	+	34	3277	c.3147C>T	c.(3145-3147)caC>caT	p.H1049H	TBCD_ENST00000539345.2_Silent_p.H1049H	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D	1049					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			CGCTGGACCACGTGCTCACCC	0.567000													23	37					0	0	1	0	0
PUM2	23369	broad.mit.edu	37	2	20508191	20508191	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:20508191C>T	ENST00000361078.2	-	5	695	c.673G>A	c.(673-675)Gat>Aat	p.D225N	PUM2_ENST00000319801.5_Missense_Mutation_p.D225N|PUM2_ENST00000403432.1_Missense_Mutation_p.D225N|PUM2_ENST00000338086.5_Missense_Mutation_p.D225N|PUM2_ENST00000536417.1_Missense_Mutation_p.D169N|PUM2_ENST00000420234.1_5'UTR			Q8TB72	PUM2_HUMAN	pumilio RNA-binding family member 2	225	Interaction with SNAPIN.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(7)|lung(13)|ovary(2)|prostate(4)|urinary_tract(3)	42	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCATGGCATCCAGATTCTGA	0.433000													35	77					0	0	1	0	0
TATDN2	9797	broad.mit.edu	37	3	10312526	10312526	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:10312526G>C	ENST00000287652.4	+	4	2711	c.1660G>C	c.(1660-1662)Gag>Cag	p.E554Q	TATDN2_ENST00000448281.2_Missense_Mutation_p.E554Q|RP11-438J1.1_ENST00000450534.1_3'UTR	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	554						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						GCTGTTGAAAGAGGATCTGGT	0.493000													41	81					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81960775	81960775	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:81960775G>C	ENST00000359376.3	+	23	2720	c.2506G>C	c.(2506-2508)Gaa>Caa	p.E836Q		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	836					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						CGAGGAGCTAGAAAAGCAGGT	0.502000													18	152					0	0	1	0	0
CEP85	64793	broad.mit.edu	37	1	26584196	26584196	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:26584196A>T	ENST00000252992.4	+	5	1143	c.1012A>T	c.(1012-1014)Aag>Tag	p.K338*	CEP85_ENST00000451429.2_Nonsense_Mutation_p.K287*	NM_001281517.1|NM_022778.2	NP_001268446.1|NP_073615.2	Q6P2H3	CEP85_HUMAN	centrosomal protein 85kDa	338						centrosome|nucleolus|spindle pole				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(11)|skin(2)	25						ACACCTTCTGAAGGAAAAAGA	0.507000													23	121					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119121138	119121138	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:119121138G>A	ENST00000264245.4	+	10	2071	c.1539G>A	c.(1537-1539)ccG>ccA	p.P513P		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	513					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						GAACACCCCCGAAGGAGCTGC	0.582000													9	60					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75798870	75798870	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:75798870C>A	ENST00000322507.8	-	64	9271	c.8962G>T	c.(8962-8964)Gaa>Taa	p.E2988*	COL12A1_ENST00000483888.2_Nonsense_Mutation_p.E2984*|COL12A1_ENST00000345356.6_Nonsense_Mutation_p.E1824*|COL12A1_ENST00000416123.2_Nonsense_Mutation_p.E2912*	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2988	Triple-helical region (COL1) with 2 imperfections.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						GTACCCCTTTCACCTTTCTCT	0.448000													5	15					0.0293803	0.0294975	1	1	0
PTPRB	5787	broad.mit.edu	37	12	70929906	70929906	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:70929906G>C	ENST00000334414.6	-	29	6024	c.5980C>G	c.(5980-5982)Cag>Gag	p.Q1994E	PTPRB_ENST00000550358.1_Missense_Mutation_p.Q1906E|PTPRB_ENST00000261266.5_Missense_Mutation_p.Q1776E|RP11-588H23.3_ENST00000546836.1_RNA|PTPRB_ENST00000451516.2_Missense_Mutation_p.Q1686E|RP11-588H23.3_ENST00000547656.1_RNA|PTPRB_ENST00000538708.1_Missense_Mutation_p.Q1686E|PTPRB_ENST00000550857.1_Missense_Mutation_p.Q1686E|RP11-588H23.3_ENST00000549460.1_RNA|RP11-588H23.3_ENST00000548687.1_RNA|RP11-588H23.3_ENST00000551438.1_RNA	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1776					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGCGGTCCCTGAGTGACAATG	0.453000													8	26					0	0	1	0	0
HIST1H2BC	8347	broad.mit.edu	37	6	26123904	26123904	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:26123904C>T	ENST00000314332.5	-	1	234	c.229G>A	c.(229-231)Gag>Aag	p.E77K	HIST1H2BC_ENST00000396984.1_Missense_Mutation_p.E77K			P62807	H2B1C_HUMAN	histone cluster 1, H2bc	77					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	16						CGGGAAGCCTCGCCCGCGATG	0.587000													42	102					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3673349	3673349	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:3673349G>A	ENST00000294600.2	+	4	690	c.606G>A	c.(604-606)aaG>aaA	p.K202K		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	202										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		ACTTGCGGAAGAGGAGAAAAT	0.557000													37	70					0	0	1	0	0
SEC62	7095	broad.mit.edu	37	3	169694737	169694737	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:169694737C>T	ENST00000337002.4	+	3	207	c.149C>T	c.(148-150)tCa>tTa	p.S50L	SEC62_ENST00000480708.1_Missense_Mutation_p.S50L	NM_003262.3	NP_003253.1	Q99442	SEC62_HUMAN	SEC62 homolog (S. cerevisiae)	50					cotranslational protein targeting to membrane|transmembrane transport	aggresome|endoplasmic reticulum membrane|integral to membrane|intermediate filament cytoskeleton|rough endoplasmic reticulum	protein transporter activity|receptor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	9						TCTTTAGCTTCAAAAGCAGTG	0.348000													11	19					0	0	1	0	0
C1QTNF5	114902	broad.mit.edu	37	11	119210397	119210397	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:119210397C>T	ENST00000445041.2	-	15	3171	c.376G>A	c.(376-378)Gac>Aac	p.D126N	C1QTNF5_ENST00000525657.1_5'UTR|MFRP_ENST00000555262.1_3'UTR|C1QTNF5_ENST00000528368.1_Missense_Mutation_p.D126N|MFRP_ENST00000530681.1_3'UTR	NM_001278431.1|NM_015645.3|NM_031433.2	NP_001265360.1|NP_056460.1|NP_113621.1	Q9BY79	MFRP_HUMAN	C1q and tumor necrosis factor related protein 5	0					embryo development	integral to membrane				endometrium(1)|lung(2)	3		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		AGCACGCGGTCGAAGGGCAAG	0.687000													11	5					0	0	1	0	0
SRPRB	58477	broad.mit.edu	37	3	133525492	133525492	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:133525492G>C	ENST00000466490.2	+	3	479	c.194G>C	c.(193-195)aGa>aCa	p.R65T		NM_021203.3	NP_067026.3	Q9Y5M8	SRPRB_HUMAN	signal recognition particle receptor, B subunit	65						endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			breast(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|urinary_tract(2)	12						AGCAGTCAGAGAGCTGTTCTT	0.408000													25	63					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134034817	134034817	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:134034817G>C	ENST00000359428.5	+	18	2628	c.2484G>C	c.(2482-2484)gtG>gtC	p.V828V	RP11-544A12.4_ENST00000587408.1_RNA|NUP214_ENST00000411637.2_Silent_p.V818V|RP11-544A12.4_ENST00000588378.1_RNA|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000589128.1_RNA|RP11-544A12.4_ENST00000417798.2_RNA|RP11-544A12.4_ENST00000589667.1_RNA|NUP214_ENST00000451030.1_Silent_p.V829V|RP11-544A12.4_ENST00000590461.1_RNA|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000589540.1_RNA|RP11-544A12.4_ENST00000415391.2_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	828	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TCCAAGATGTGAATGATGTTC	0.368000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								12	33					0	0	1	0	0
HIST1H2AE	3012	broad.mit.edu	37	6	26217476	26217476	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:26217476G>A	ENST00000303910.2	+	1	312	c.274G>A	c.(274-276)Gag>Aag	p.E92K		NM_021052.2	NP_066390.1	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	92					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)	10		all_hematologic(11;0.196)				CCGCAACGACGAGGAGCTAAA	0.597000													22	70					0	0	1	0	0
IP6K2	51447	broad.mit.edu	37	3	48732441	48732441	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:48732441G>A	ENST00000431721.2	-	3	686	c.449C>T	c.(448-450)tCc>tTc	p.S150F	IP6K2_ENST00000450045.1_Intron|IP6K2_ENST00000453202.1_Missense_Mutation_p.S95F|IP6K2_ENST00000328631.5_Intron|IP6K2_ENST00000340879.4_Intron|IP6K2_ENST00000443964.1_Missense_Mutation_p.S154F|IP6K2_ENST00000449610.1_Missense_Mutation_p.S95F|IP6K2_ENST00000436134.1_Intron|IP6K2_ENST00000413298.1_Intron|IP6K2_ENST00000432678.2_Intron|IP6K2_ENST00000446860.1_Missense_Mutation_p.S153F|IP6K2_ENST00000417896.1_Missense_Mutation_p.S95F	NM_001190316.1	NP_001177245.1	Q9UHH9	IP6K2_HUMAN	inositol hexakisphosphate kinase 2	0					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	15						GGGCTCCAGGGATGGCTGCCA	0.597000													10	24					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152369279	152369279	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:152369279G>C	ENST00000427231.2	-	161	23516	c.23314C>G	c.(23314-23316)Cat>Gat	p.H7772D	NEB_ENST00000172853.10_Missense_Mutation_p.H6071D|NEB_ENST00000603639.1_Missense_Mutation_p.H7772D|NEB_ENST00000397345.3_Missense_Mutation_p.H7772D|NEB_ENST00000604864.1_Missense_Mutation_p.H7772D|NEB_ENST00000409198.1_Missense_Mutation_p.H6071D	NM_001164507.1|NM_001271208.1	NP_001157979|NP_001258137.1	P20929	NEBU_HUMAN	nebulin	6071					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGTTGGGCATGAATGATCTCT	0.393000													4	18					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36242531	36242531	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:36242531G>A	ENST00000540320.1	+	57	9159	c.8625G>A	c.(8623-8625)caG>caA	p.Q2875Q	NBEA_ENST00000537702.1_Silent_p.Q668Q|NBEA_ENST00000379922.3_Silent_p.Q453Q|NBEA_ENST00000400445.3_Silent_p.Q2875Q|NBEA_ENST00000379939.2_Silent_p.Q2872Q|NBEA_ENST00000310336.4_Silent_p.Q2875Q			Q8NFP9	NBEA_HUMAN	neurobeachin	2875						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GTGACGGCCAGAACCTGGTCA	0.433000													8	9					0	0	1	0	0
ZNF77	58492	broad.mit.edu	37	19	2939325	2939325	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:2939325G>C	ENST00000314531.4	-	2	176	c.84C>G	c.(82-84)ctC>ctG	p.L28L		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	28	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		CATCTCTGTAGAGGCTCCTCT	0.537000													27	27					0	0	1	0	0
DTX3L	151636	broad.mit.edu	37	3	122287833	122287833	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:122287833G>T	ENST00000296161.4	+	3	1086	c.897G>T	c.(895-897)caG>caT	p.Q299H	DTX3L_ENST00000383661.3_Intron	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	299					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		GTGAATTTCAGAAGAACACAG	0.413000													17	47					3.41278e-10	3.55395e-10	1	1	0
PPP2R5C	5527	broad.mit.edu	37	14	102349793	102349793	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:102349793G>C	ENST00000422945.2	+	7	712	c.616G>C	c.(616-618)Gat>Cat	p.D206H	PPP2R5C_ENST00000445439.3_Missense_Mutation_p.D175H|PPP2R5C_ENST00000350249.3_Missense_Mutation_p.D175H|PPP2R5C_ENST00000328724.5_Missense_Mutation_p.D230H|PPP2R5C_ENST00000557095.1_Missense_Mutation_p.D175H|PPP2R5C_ENST00000334743.5_Missense_Mutation_p.D175H	NM_001161725.1	NP_001155197.1	Q13362	2A5G_HUMAN	protein phosphatase 2, regulatory subunit B', gamma	175					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity	p.D175Y(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20						TGACAGTGAAGATCCTCGGGA	0.388000													57	73					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11806137	11806137	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:11806137G>A	ENST00000262442.4	+	60	11576	c.11508G>A	c.(11506-11508)gaG>gaA	p.E3836E	DNAH9_ENST00000396001.2_3'UTR|DNAH9_ENST00000608377.1_Silent_p.E148E|DNAH9_ENST00000454412.2_Silent_p.E3836E	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTGAGAAAGAGAAGCTCCCAC	0.507000													26	32					0	0	1	0	0
ZBTB24	9841	broad.mit.edu	37	6	109802545	109802545	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:109802545C>T	ENST00000230122.3	-	2	852	c.685G>A	c.(685-687)Gag>Aag	p.E229K		NM_001164313.1|NM_014797.2	NP_001157785.1|NP_055612.2	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		GGCATTTCCTCCTCTCTACTT	0.463000													35	113					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71364669	71364669	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:71364669C>A	ENST00000392650.3	-	37	5044	c.5044G>T	c.(5044-5046)Gag>Tag	p.E1682*	SDK2_ENST00000410094.1_5'UTR|SDK2_ENST00000388726.3_Nonsense_Mutation_p.E1663*	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1682	Fibronectin type-III 11.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						ACGCTGTTCTCAGCCAGGAAA	0.597000													8	8					1.12685e-05	1.14274e-05	1	1	0
CUBN	8029	broad.mit.edu	37	10	17113560	17113560	+	Silent	SNP	A	A	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:17113560A>G	ENST00000377833.4	-	19	2555	c.2490T>C	c.(2488-2490)ccT>ccC	p.P830P		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	830	CUB 4.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TAGGAAAAAAAGGCGAGCGAA	0.413000													3	61					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178540947	178540947	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:178540947G>A	ENST00000251582.7	-	22	3658	c.3557C>T	c.(3556-3558)cCc>cTc	p.P1186L		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	1186					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CTTTTCATAGGGGCTCGGTCG	0.468000													40	33					0	0	1	0	0
CCR6	1235	broad.mit.edu	37	6	167550180	167550180	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:167550180C>G	ENST00000341935.5	+	3	1014	c.462C>G	c.(460-462)ttC>ttG	p.F154L	CCR6_ENST00000400926.2_Missense_Mutation_p.F154L|RP11-517H2.6_ENST00000609590.1_RNA|CCR6_ENST00000349984.4_Missense_Mutation_p.F154L	NM_031409.3	NP_113597.2	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	154					cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	14		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		CTAAGTCATTCCGGCTCCGAT	0.493000													16	36					0	0	1	0	0
EXOSC8	11340	broad.mit.edu	37	13	37582296	37582296	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:37582296C>T	ENST00000389704.3	+	9	855	c.590C>T	c.(589-591)tCc>tTc	p.S197F		NM_181503.2	NP_852480.1	Q96B26	EXOS8_HUMAN	exosome component 8	197					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	AU-rich element binding|identical protein binding			biliary_tract(1)|breast(1)|kidney(2)|pancreas(1)|prostate(1)|skin(1)	7		Lung NSC(96;6.57e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.67e-07)|Epithelial(112;1.31e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00699)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0411)		GTTGCAACTTCCTTTGCTGTG	0.294000													32	81					0	0	1	0	0
C8orf31	286122	broad.mit.edu	37	8	144130655	144130655	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:144130655C>T	ENST00000395172.1	+	5	737	c.385C>T	c.(385-387)Ctc>Ttc	p.L129F	C8orf31_ENST00000517653.1_3'UTR	NM_173687.2	NP_775958.1	Q8N9H6	CH031_HUMAN	chromosome 8 open reading frame 31	129										breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)	10	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					gaaccaccttctctactctca	0.478000													25	39					0	0	1	0	0
BCAP29	55973	broad.mit.edu	37	7	107234409	107234409	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:107234409G>C	ENST00000379119.2	+	3	217	c.203G>C	c.(202-204)aGa>aCa	p.R68T	BCAP29_ENST00000379117.2_Missense_Mutation_p.R68T|BCAP29_ENST00000465919.1_5'UTR|BCAP29_ENST00000494086.1_3'UTR|BCAP29_ENST00000445771.2_Missense_Mutation_p.R68T|BCAP29_ENST00000005259.4_Missense_Mutation_p.R68T	NM_001008405.2	NP_001008405.1	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein 29	68					apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				cervix(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	14						GATGCTGTGAGAGAAGTAAGG	0.363000													17	32					0	0	1	0	0
SLC25A14	9016	broad.mit.edu	37	X	129499587	129499587	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:129499587G>A	ENST00000218197.5	+	8	1019	c.792G>A	c.(790-792)atG>atA	p.M264I	SLC25A14_ENST00000361980.5_Missense_Mutation_p.M261I|SLC25A14_ENST00000467496.1_3'UTR|SLC25A14_ENST00000543953.1_3'UTR|SLC25A14_ENST00000339231.3_Missense_Mutation_p.M292I	NM_001282195.1|NM_001282196.1|NM_001282198.1	NP_001269124.1|NP_001269125.1|NP_001269127.1	O95258	UCP5_HUMAN	solute carrier family 25 (mitochondrial carrier, brain), member 14	264					aerobic respiration|mitochondrial transport	integral to plasma membrane|mitochondrial inner membrane	binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)	22						CTCGCATGATGAACCAGAGGG	0.453000													39	115					0	0	1	0	0
HIST1H3F	8968	broad.mit.edu	37	6	26250661	26250661	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:26250661G>C	ENST00000446824.2	-	1	174	c.173C>G	c.(172-174)tCg>tGg	p.S58W		NM_021018.2	NP_066298.1	P68431	H31_HUMAN	histone cluster 1, H3f	58					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			lung(6)|urinary_tract(1)	7						TAGCTCAGTCGATTTCTGATA	0.607000											OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	48	97					0	0	1	0	0
PELI1	57162	broad.mit.edu	37	2	64321919	64321919	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:64321919G>A	ENST00000358912.4	-	7	1616	c.1174C>T	c.(1174-1176)Cat>Tat	p.H392Y		NM_020651.3	NP_065702.2	Q96FA3	PELI1_HUMAN	pellino E3 ubiquitin protein ligase 1	392					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	19						CAGGCTGCATGAAAAGTATGA	0.478000													26	56					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60194249	60194249	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:60194249C>T	ENST00000267484.5	-	3	1488	c.1153G>A	c.(1153-1155)Gag>Aag	p.E385K		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	385					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GCCTTGACCTCGGGCCTGTCG	0.652000													4	12					0	0	1	0	0
RELB	5971	broad.mit.edu	37	19	45540670	45540670	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:45540670C>T	ENST00000221452.8	+	12	1512	c.1362C>T	c.(1360-1362)ttC>ttT	p.F454F	RELB_ENST00000540120.1_Silent_p.F454F|RELB_ENST00000505236.1_Silent_p.F451F	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	454						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		TAGGCCCGTTCCTCCCGCCGT	0.592000													68	53					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17113832	17113832	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:17113832G>A	ENST00000377833.4	-	18	2505	c.2440C>T	c.(2440-2442)Caa>Taa	p.Q814*		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	814	CUB 3.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTACCGACTTGATAAACAGCT	0.299000													38	96					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160765992	160765992	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:160765992G>C	ENST00000368037.5	+	1	129	c.15G>C	c.(13-15)aaG>aaC	p.K5N	LY9_ENST00000341032.4_Missense_Mutation_p.K5N|LY9_ENST00000368039.2_Missense_Mutation_p.K5N|LY9_ENST00000392203.4_Missense_Mutation_p.K5N|LY9_ENST00000368041.2_5'UTR|LY9_ENST00000263285.6_Missense_Mutation_p.K5N|LY9_ENST00000368040.1_5'UTR	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9						cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TGGCACCAAAGAGTCACACAG	0.488000													18	109					0	0	1	0	0
MIOS	54468	broad.mit.edu	37	7	7625410	7625410	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:7625410G>A	ENST00000340080.4	+	7	2213	c.1792G>A	c.(1792-1794)Gaa>Aaa	p.E598K	MIOS_ENST00000405785.1_Missense_Mutation_p.E598K	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)	598										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TCTGACAAGTGAAACAGGATC	0.343000													31	73					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42635352	42635352	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:42635352C>G	ENST00000358131.5	+	3	566	c.358C>G	c.(358-360)Cag>Gag	p.Q120E	TOX2_ENST00000372999.1_Missense_Mutation_p.Q69E|TOX2_ENST00000341197.4_Missense_Mutation_p.Q111E|TOX2_ENST00000423191.2_Missense_Mutation_p.Q69E	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.Q69*(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CTACTCCTATCAGGCCATGGA	0.652000													12	38					0	0	1	0	0
POLR2M	81488	broad.mit.edu	37	15	58000997	58000997	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:58000997G>C	ENST00000299638.3	+	2	413	c.199G>C	c.(199-201)Gaa>Caa	p.E67Q	GCOM1_ENST00000380569.2_Intron|POLR2M_ENST00000380563.2_Missense_Mutation_p.E67Q|GCOM1_ENST00000587652.1_Missense_Mutation_p.E464Q|GCOM1_ENST00000380568.3_Intron|POLR2M_ENST00000464308.1_3'UTR|POLR2M_ENST00000380557.4_Intron|GCOM1_ENST00000484300.1_Intron	NM_015532.3	NP_056347.1			polymerase (RNA) II (DNA directed) polypeptide M																		AGAATGTGAAGAAGTTAGAAG	0.373000													15	55					0	0	1	0	0
CUL5	8065	broad.mit.edu	37	11	107917093	107917093	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:107917093G>A	ENST00000393094.2	+	3	847	c.231G>A	c.(229-231)caG>caA	p.Q77Q		NM_003478.3	NP_003469.2	Q93034	CUL5_HUMAN	cullin 5	77					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		AGCAAGCACAGGCAGTAAGTT	0.318000													13	35					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40655992	40655992	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:40655992C>T	ENST00000267889.3	+	2	373	c.286C>T	c.(286-288)Ccc>Tcc	p.P96S		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	96				P -> T (in Ref. 1; BAB21833).	smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CTTCACCTATCCCCGGGCACT	0.657000													12	47					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173337537	173337537	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:173337537C>T	ENST00000375221.2	+	6	1014	c.811C>T	c.(811-813)Cct>Tct	p.P271S	ITGA6_ENST00000264106.6_Missense_Mutation_p.P271S|ITGA6_ENST00000409532.1_Missense_Mutation_p.P113S|ITGA6_ENST00000343713.4_Missense_Mutation_p.P227S|ITGA6_ENST00000264107.7_Intron|ITGA6_ENST00000409080.1_Intron			P23229	ITA6_HUMAN	integrin, alpha 6	271					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			CTATACAGATCCTGATCAGTT	0.478000													27	49					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	94482494	94482494	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:94482494C>T	ENST00000377047.4	+	3	1022	c.407C>T	c.(406-408)tCa>tTa	p.S136L	GPC6-AS2_ENST00000445540.1_RNA	NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	136						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				ATGCAGAATTCAGAAGTCTTC	0.448000													13	65					0	0	1	0	0
KCNK16	83795	broad.mit.edu	37	6	39285594	39285594	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:39285594C>G	ENST00000425054.2	-	3	462	c.463G>C	c.(463-465)Gaa>Caa	p.E155Q	KCNK16_ENST00000507712.1_Missense_Mutation_p.E90Q|KCNK16_ENST00000373227.4_Missense_Mutation_p.E155Q|KCNK16_ENST00000373229.5_Missense_Mutation_p.E155Q|KCNK16_ENST00000437525.2_Missense_Mutation_p.E155Q	NM_001135105.1	NP_001128577.1	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	155						integral to membrane	potassium channel activity|voltage-gated ion channel activity			large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)	13						TCCCATCTTTCAATGGCGGCC	0.587000													5	7					0	0	1	0	0
ASAP2	8853	broad.mit.edu	37	2	9540151	9540151	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:9540151G>C	ENST00000281419.3	+	25	3024		c.e25-1		ASAP2_ENST00000491413.1_Splice_Site|ASAP2_ENST00000315273.4_Splice_Site	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2						regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						TGTCTTTGTAGGGCTGACAAG	0.493000													19	23					0	0	1	0	0
SYNGR1	9145	broad.mit.edu	37	22	39770461	39770461	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:39770461C>T	ENST00000328933.5	+	2	255	c.240C>T	c.(238-240)ctC>ctT	p.L80L	SYNGR1_ENST00000318801.4_Silent_p.L80L|SYNGR1_ENST00000381535.4_Silent_p.L81L|SYNGR1_ENST00000216155.7_Silent_p.L80L|SYNGR1_ENST00000406293.3_Silent_p.L80L	NM_004711.4	NP_004702.2			synaptogyrin 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	7	Melanoma(58;0.04)					TCGCCTTCCTCACCTGCCTGC	0.637000													21	43					0	0	1	0	0
SPATA8	145946	broad.mit.edu	37	15	97327388	97327388	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:97327388C>T	ENST00000328504.3	+	2	362	c.95C>T	c.(94-96)tCg>tTg	p.S32L	SPATA8_ENST00000558553.1_5'UTR	NM_173499.3	NP_775770.1	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	32										large_intestine(4)|lung(8)|ovary(1)|skin(3)	16	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			TGCAGAACCTCGTCGCGACAT	0.567000													17	32					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111979333	111979333	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:111979333G>A	ENST00000374566.3	-	16	2019	c.1502C>T	c.(1501-1503)tCa>tTa	p.S501L		NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	501						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						atgcCTTCCTGAAGCTGCGGT	0.592000													30	28					0	0	1	0	0
KCNA2	3737	broad.mit.edu	37	1	111147039	111147039	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:111147039C>G	ENST00000485317.1	-	3	1039	c.366G>C	c.(364-366)gcG>gcC	p.A122A	KCNA2_ENST00000440270.1_Silent_p.A122A|KCNA2_ENST00000369770.3_Silent_p.A122A|KCNA2_ENST00000525120.1_Intron|KCNA2_ENST00000316361.4_Silent_p.A122A			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	122						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		ACATCTCCATCGCTTCTTCTC	0.468000													6	42					0	0	1	0	0
CLUL1	27098	broad.mit.edu	37	18	627096	627096	+	Splice_Site	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr18:627096G>T	ENST00000581619.1	+	5	1345		c.e5-1		CLUL1_ENST00000540035.1_Splice_Site|CLUL1_ENST00000580436.1_Splice_Site|CLUL1_ENST00000400606.2_Splice_Site|CLUL1_ENST00000338387.7_Splice_Site|CLUL1_ENST00000579494.1_Splice_Site			Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal)						cell death	extracellular region				NS(1)|breast(1)|endometrium(5)|large_intestine(5)|liver(2)|lung(7)|ovary(2)|skin(1)	24						CTACTCCACAGATTGAACGGT	0.338000													14	41					7.93312e-07	8.10208e-07	1	1	0
RPA4	29935	broad.mit.edu	37	X	96139571	96139571	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:96139571A>T	ENST00000373040.3	+	1	665	c.262A>T	c.(262-264)Aat>Tat	p.N88Y	DIAPH2_ENST00000373049.4_Intron|DIAPH2_ENST00000373061.3_Intron|DIAPH2_ENST00000373054.4_Intron|DIAPH2_ENST00000324765.8_Intron|DIAPH2_ENST00000355827.4_Intron	NM_013347.4	NP_037479.1	Q13156	RFA4_HUMAN	replication protein A4, 30kDa	88					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	13						GAAGGCTTCAAATCACATTTG	0.468000								Other identified genes with known or suspected DNA repair function					13	29					0	0	1	0	0
EYA4	2070	broad.mit.edu	37	6	133802665	133802665	+	Silent	SNP	G	G	A	rs140170914	byFrequency	TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:133802665G>A	ENST00000367895.5	+	12	1499	c.1035G>A	c.(1033-1035)agG>agA	p.R345R	EYA4_ENST00000431403.2_Silent_p.R345R|EYA4_ENST00000531901.1_Silent_p.R351R|EYA4_ENST00000430974.2_Silent_p.R297R|EYA4_ENST00000452339.2_Silent_p.R291R|EYA4_ENST00000525849.1_Silent_p.R322R|EYA4_ENST00000355167.3_Silent_p.R345R|EYA4_ENST00000355286.6_Silent_p.R322R	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	345					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		GAACCTGTAGGAGTTCTGGGT	0.458000													26	65					0	0	1	0	0
DAK	26007	broad.mit.edu	37	11	61110063	61110063	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:61110063G>A	ENST00000394900.3	+	9	937	c.708G>A	c.(706-708)gaG>gaA	p.E236E		NM_015533.3	NP_056348.2	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2 homolog (S. cerevisiae)	236	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding			NS(1)|breast(3)|endometrium(3)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	23						CCGCCGATGAGATTGTGAAAC	0.617000													30	50					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33954408	33954408	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:33954408C>T	ENST00000389232.4	+	35	4747	c.4677C>T	c.(4675-4677)taC>taT	p.Y1559Y	RYR3_ENST00000415757.3_Silent_p.Y1559Y	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1559	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGTTCCATTACCACACGCTGA	0.617000													6	8					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91131800	91131800	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:91131800C>T	ENST00000373094.1	+	2	1406	c.561C>T	c.(559-561)ctC>ctT	p.L187L	PCDH11X_ENST00000395337.2_Silent_p.L187L|PCDH11X_ENST00000406881.1_Silent_p.L187L|PCDH11X_ENST00000373088.1_Silent_p.L187L|PCDH11X_ENST00000504220.2_Silent_p.L187L|PCDH11X_ENST00000361655.2_Silent_p.L187L|PCDH11X_ENST00000298274.8_Silent_p.L187L|PCDH11X_ENST00000373097.1_Silent_p.L187L|PCDH11X_ENST00000361724.1_Silent_p.L187L	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	187	Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding	p.L187L(3)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TTTTTGGCCTCGATGTCATTG	0.303000													12	51					0	0	1	0	0
ZNF317	57693	broad.mit.edu	37	19	9271555	9271555	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:9271555C>G	ENST00000247956.6	+	7	1539	c.1234C>G	c.(1234-1236)Cac>Gac	p.H412D	ZNF317_ENST00000360385.3_Missense_Mutation_p.H380D	NM_020933.4	NP_065984.3	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	27						CATGAGGATTCACATCGTCAA	0.493000													3	42					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372607	126372607	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:126372607C>A	ENST00000394329.3	+	9	10449	c.10436C>A	c.(10435-10437)tCa>tAa	p.S3479*	FAT4_ENST00000335110.5_Nonsense_Mutation_p.S1777*	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3479	Cadherin 33.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TATAATCTCTCAGTTTTGGCT	0.453000													36	57					5.44703e-19	5.79214e-19	1	1	0
REV3L	5980	broad.mit.edu	37	6	111694276	111694276	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:111694276G>C	ENST00000435970.1	-	15	5864	c.5048C>G	c.(5047-5049)tCt>tGt	p.S1683C	REV3L_ENST00000368805.1_Missense_Mutation_p.S1761C|REV3L_ENST00000358835.3_Missense_Mutation_p.S1761C|REV3L_ENST00000368802.3_Missense_Mutation_p.S1761C			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1761					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AACACAGAAAGAATCCATTAT	0.403000								DNA polymerases (catalytic subunits)					37	105					0	0	1	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58190191	58190191	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:58190191A>T	ENST00000318203.5	+	5	1917	c.1220A>T	c.(1219-1221)cAg>cTg	p.Q407L		NM_152677.2	NP_689890.1	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	407					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|liver(2)|lung(17)|ovary(1)|skin(1)|stomach(1)	30		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGCTACCGCCAGTCATCCACA	0.473000													97	44					0	0	1	0	0
PUSL1	126789	broad.mit.edu	37	1	1246357	1246357	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:1246357G>A	ENST00000379031.5	+	7	845	c.768G>A	c.(766-768)acG>acA	p.T256T	PUSL1_ENST00000470520.1_3'UTR	NM_153339.1	NP_699170.1	Q8N0Z8	PUSL1_HUMAN	pseudouridylate synthase-like 1	256					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			lung(3)|skin(1)|urinary_tract(1)	5	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGGTGAAGACGATTCTGGAGA	0.622000													35	58					0	0	1	0	0
FOXO3	2309	broad.mit.edu	37	6	108985225	108985225	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:108985225C>T	ENST00000406360.1	+	2	1532	c.1189C>T	c.(1189-1191)Ccg>Tcg	p.P397S	FOXO3_ENST00000540898.1_Missense_Mutation_p.P177S|FOXO3_ENST00000343882.6_Missense_Mutation_p.P397S	NM_001455.3	NP_001446.1	O43524	FOXO3_HUMAN	forkhead box O3	397					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		CATCACGCTCCCGCCATCCCA	0.597000													9	24					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20489937	20489937	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:20489937G>A	ENST00000573854.1	+	10	1333	c.1219G>A	c.(1219-1221)Gaa>Aaa	p.E407K	ACSM2A_ENST00000417235.2_Missense_Mutation_p.E328K|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000396104.2_Missense_Mutation_p.E407K|ACSM2A_ENST00000219054.6_Missense_Mutation_p.E407K|ACSM2A_ENST00000536134.1_Missense_Mutation_p.E179K|ACSM2A_ENST00000575690.1_Missense_Mutation_p.E407K	NM_001010845.2	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	407					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						CCCCGGCACAGAAGGAGACAT	0.517000													21	46					0	0	1	0	0
MITF	4286	broad.mit.edu	37	3	69998236	69998236	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:69998236G>A	ENST00000352241.4	+	6	960	c.797G>A	c.(796-798)gGa>gAa	p.G266E	MITF_ENST00000394351.3_Missense_Mutation_p.G159E|MITF_ENST00000314589.5_Missense_Mutation_p.G250E|MITF_ENST00000531774.1_Missense_Mutation_p.G103E|MITF_ENST00000314557.6_Missense_Mutation_p.G159E|MITF_ENST00000448226.2_Missense_Mutation_p.G266E|MITF_ENST00000328528.6_Missense_Mutation_p.G265E|MITF_ENST00000472437.1_Missense_Mutation_p.G214E|MITF_ENST00000394355.2_Missense_Mutation_p.G241E	NM_198159.2	NP_937802.1	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	266	Transactivation.				melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(6)|stomach(1)|urinary_tract(2)	30		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		GATCTTTATGGAAACCAAGGT	0.433000			A		melanoma		"""Waardenburg syndrome type 2, Tietz syndrome"""						22	72					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	441372	441372	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:441372C>G	ENST00000432829.2	+	41	5422	c.5106C>G	c.(5104-5106)ctC>ctG	p.L1702L	DOCK8_ENST00000453981.1_Silent_p.L1770L|DOCK8_ENST00000469391.1_Silent_p.L1670L|DOCK8_ENST00000382329.1_Silent_p.L1237L	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1770	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		AGCTGACACTCACTCACAGCA	0.547000													52	24					0	0	1	0	0
HNRNPA1	3178	broad.mit.edu	37	12	54676013	54676013	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:54676013G>A	ENST00000546500.1	+	4	1034	c.419G>A	c.(418-420)cGa>cAa	p.R140Q	RP11-968A15.8_ENST00000553061.1_RNA|HNRNPA1_ENST00000547276.1_Missense_Mutation_p.R140Q|HNRNPA1_ENST00000330752.8_Missense_Mutation_p.R140Q|HNRNPA1_ENST00000340913.6_Missense_Mutation_p.R140Q			P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	140	Globular B domain.|RRM 2.			R -> P (in Ref. 8; CAA27874).	interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20						ATGACTGACCGAGGCAGTGGC	0.388000													12	31					0	0	1	0	0
ZNF572	137209	broad.mit.edu	37	8	125989952	125989952	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:125989952C>G	ENST00000319286.5	+	3	1596	c.1442C>G	c.(1441-1443)gCc>gGc	p.A481G		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	481					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.A481G(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AGCAGAAGTGCCTACCTCAGT	0.468000										HNSCC(60;0.17)			25	137					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45355600	45355600	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:45355600C>T	ENST00000359271.2	+	3	1636	c.1386C>T	c.(1384-1386)atC>atT	p.I462I		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	462						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				ACCTCTTCATCAGCCTCTCCT	0.507000													63	60					0	0	1	0	0
PELI1	57162	broad.mit.edu	37	2	64321928	64321928	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:64321928G>A	ENST00000358912.4	-	7	1607	c.1165C>T	c.(1165-1167)Cat>Tat	p.H389Y		NM_020651.3	NP_065702.2	Q96FA3	PELI1_HUMAN	pellino E3 ubiquitin protein ligase 1	389					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	19						TGAAAAGTATGAGTACCATGA	0.498000													29	50					0	0	1	0	0
SCARA3	51435	broad.mit.edu	37	8	27509101	27509101	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:27509101C>T	ENST00000301904.3	+	3	203	c.183C>T	c.(181-183)ttC>ttT	p.F61F	SCARA3_ENST00000337221.4_Silent_p.F61F	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	61					response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		TTTACCTCTTCCTGGCCCTGC	0.647000													32	55					0	0	1	0	0
EEF1A2	1917	broad.mit.edu	37	20	62129093	62129093	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:62129093G>C	ENST00000217182.3	-	2	189	c.24C>G	c.(22-24)atC>atG	p.I8M	EEF1A2_ENST00000298049.7_Missense_Mutation_p.I8M	NM_001958.3	NP_001949.1	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha 2	8						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(14)|stomach(1)	20	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CCACGATGTTGATGTGGGTCT	0.592000													16	101					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205028799	205028799	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:205028799C>T	ENST00000331830.4	+	7	1070	c.786C>T	c.(784-786)ttC>ttT	p.F262F		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	262	Ig-like C2-type 3.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGGAGTGCTTCGCCTTTGGGA	0.627000													38	58					0	0	1	0	0
OR14I1	401994	broad.mit.edu	37	1	248844843	248844843	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:248844843A>G	ENST00000342623.3	-	1	786	c.763T>C	c.(763-765)Ttt>Ctt	p.F255L		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						AAGGCAGCAAAGAGCCCTGTG	0.483000													34	63					0	0	1	0	0
B3GNT1	11041	broad.mit.edu	37	11	66114984	66114984	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:66114984G>C	ENST00000311181.4	-	1	179	c.33C>G	c.(31-33)ttC>ttG	p.F11L		NM_006876.2	NP_006867.1	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1	11					poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|kidney(1)|large_intestine(2)|lung(6)|urinary_tract(1)	12						GCAGCTGGTAGAAGGCGCACC	0.677000													6	7					0	0	1	0	0
GLRB	2743	broad.mit.edu	37	4	158065100	158065100	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:158065100G>A	ENST00000264428.4	+	8	1163	c.893G>A	c.(892-894)aGa>aAa	p.R298K	GLRB_ENST00000509282.1_Missense_Mutation_p.R298K|GLRB_ENST00000512619.1_Intron|GLRB_ENST00000541722.1_Missense_Mutation_p.R298K	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	298					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	AGTGCTGCCAGAGTGCCCCTG	0.463000													14	52					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152084813	152084813	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:152084813C>G	ENST00000368804.1	-	2	879	c.880G>C	c.(880-882)Gag>Cag	p.E294Q		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	294					keratinization	cytoskeleton	calcium ion binding	p.E293fs*6(1)		NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			tgctgctgctCTTCCTCCTGG	0.647000													43	62					0	0	1	0	0
SIN3A	25942	broad.mit.edu	37	15	75664520	75664520	+	Missense_Mutation	SNP	G	G	C	rs146289897		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:75664520G>C	ENST00000394947.3	-	21	3936	c.3622C>G	c.(3622-3624)Cag>Gag	p.Q1208E	SIN3A_ENST00000394949.4_Missense_Mutation_p.Q1208E|SIN3A_ENST00000360439.4_Missense_Mutation_p.Q1208E	NM_001145358.1	NP_001138830.1	Q96ST3	SIN3A_HUMAN	SIN3 transcription regulator family member A	1208					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	63						TGGAATCTCTGATGTAGACGC	0.473000													24	62					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	432049	432049	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:432049C>T	ENST00000332826.6	-	5	440	c.356G>A	c.(355-357)aGa>aAa	p.R119K		NM_001012302.2	NP_001012302	A1A5B4	ANO9_HUMAN	anoctamin 9	119						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						GATTCGGATTCTGAGACTCAA	0.637000													5	13					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803091	185803091	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:185803091G>A	ENST00000302277.6	+	4	3562	c.2968G>A	c.(2968-2970)Gag>Aag	p.E990K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	990						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GACACCAACTGAGTGGCTGCG	0.413000													13	95					0	0	1	0	0
RAD51C	5889	broad.mit.edu	37	17	56787259	56787259	+	Missense_Mutation	SNP	C	C	T	rs28363311		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:56787259C>T	ENST00000337432.4	+	5	816	c.745C>T	c.(745-747)Cgt>Tgt	p.R249C	RAD51C_ENST00000583539.1_Missense_Mutation_p.R249C	NM_058216.1	NP_478123.1	O43502	RA51C_HUMAN	RAD51 paralog C	249			R -> C (in dbSNP:rs28363311).		blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity	p.R249C(1)		upper_aerodigestive_tract(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTTTCCATTTCGTCATGACCT	0.333000								Homologous recombination	Hereditary Breast-Ovarian Cancer, non-BRCA1/2				36	87					0	0	1	0	0
CHKA	1119	broad.mit.edu	37	11	67864565	67864565	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:67864565G>A	ENST00000265689.4	-	2	409	c.383C>T	c.(382-384)tCc>tTc	p.S128F	CHKA_ENST00000356135.5_Missense_Mutation_p.S128F	NM_001277.2	NP_001268.2	P35790	CHKA_HUMAN	choline kinase alpha	128					lipid transport|phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|choline kinase activity|drug binding|ethanolamine kinase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	13					Choline(DB00122)	GTCAGGTAGGGAGCACTGGAA	0.488000													13	23					0	0	1	0	0
NCAM2	4685	broad.mit.edu	37	21	22656681	22656681	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr21:22656681G>C	ENST00000400546.1	+	3	547	c.298G>C	c.(298-300)Gga>Cga	p.G100R	NCAM2_ENST00000486367.1_3'UTR|NCAM2_ENST00000284894.7_Intron|NCAM2_ENST00000535285.1_Missense_Mutation_p.G125R	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	100	Ig-like C2-type 1.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		AGATGCCAAAGGACAAACACA	0.343000													4	30					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222420	140222420	+	Missense_Mutation	SNP	C	C	G	rs146745311		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:140222420C>G	ENST00000531613.1	+	1	1514	c.1514C>G	c.(1513-1515)tCg>tGg	p.S505W	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.S505W|PCDHA5_ENST00000529619.1_Intron	NM_018911.2	NP_061734.1												p.S505L(1)		NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTCGCTGTCGAGCTACATT	0.667000													58	41					0	0	1	0	0
ZDHHC9	51114	broad.mit.edu	37	X	128957704	128957704	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:128957704G>A	ENST00000357166.6	-	5	829	c.438C>T	c.(436-438)atC>atT	p.I146I	ZDHHC9_ENST00000491039.1_5'UTR|ZDHHC9_ENST00000371064.3_Silent_p.I146I	NM_016032.3	NP_057116.2	Q9Y397	ZDHC9_HUMAN	zinc finger, DHHC-type containing 9	146						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acyltransferase activity|zinc ion binding	p.I146I(1)		breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)	19						GAGGCCGGAAGATCTTGCATG	0.512000													23	87					0	0	1	0	0
ADPGK	83440	broad.mit.edu	37	15	73067284	73067284	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:73067284C>G	ENST00000311669.8	-	2	481	c.388G>C	c.(388-390)Gag>Cag	p.E130Q	ADPGK_ENST00000567733.1_5'UTR	NM_031284.4	NP_112574.3	Q9BRR6	ADPGK_HUMAN	ADP-dependent glucokinase	130	ADPK.				glycolysis	extracellular region	ADP-specific glucokinase activity|metal ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|skin(1)	7						AAGAAGCGCTCAGCAGCTGCT	0.473000													16	43					0	0	1	0	0
VPS28	51160	broad.mit.edu	37	8	145649189	145649189	+	Nonstop_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:145649189C>G	ENST00000292510.4	-	10	754	c.665G>C	c.(664-666)tGa>tCa	p.*222S	VPS28_ENST00000377348.2_3'UTR|VPS28_ENST00000526054.1_Nonstop_Mutation_p.*222S|VPS28_ENST00000529182.1_3'UTR	NM_016208.2	NP_057292.1	Q9UK41	VPS28_HUMAN	vacuolar protein sorting 28 homolog (S. cerevisiae)	0					cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GCCCCGGGCTCAGGCATGCAG	0.617000													9	32					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152082303	152082303	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:152082303C>G	ENST00000368804.1	-	2	3389	c.3390G>C	c.(3388-3390)aaG>aaC	p.K1130N		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1130	10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ggcgccttctcttctcccgtt	0.612000													61	101					0	0	1	0	0
ELAVL1	1994	broad.mit.edu	37	19	8038740	8038740	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:8038740G>C	ENST00000407627.2	-	4	428	c.299C>G	c.(298-300)tCa>tGa	p.S100*	ELAVL1_ENST00000593807.1_Nonsense_Mutation_p.S100*|ELAVL1_ENST00000351593.5_Nonsense_Mutation_p.S127*|ELAVL1_ENST00000596459.1_Nonsense_Mutation_p.S100*	NM_001419.2	NP_001410.2	Q15717	ELAV1_HUMAN	ELAV like RNA binding protein 1	100					3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						GATCACCTCTGAGCTCGGGCG	0.542000													26	25					0	0	1	0	0
RNF40	9810	broad.mit.edu	37	16	30774487	30774487	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:30774487G>A	ENST00000324685.6	+	3	616	c.181G>A	c.(181-183)Gag>Aag	p.E61K	RNF40_ENST00000563683.1_Missense_Mutation_p.E61K|RNF40_ENST00000402121.3_Missense_Mutation_p.E61K|RNF40_ENST00000357890.5_Missense_Mutation_p.E61K	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	61					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			GAAACTGGCAGAGCGGCTGGA	0.532000													16	31					0	0	1	0	0
NLE1	54475	broad.mit.edu	37	17	33469022	33469022	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:33469022G>A	ENST00000442241.4	-	2	177	c.138C>T	c.(136-138)ctC>ctT	p.L46L	NLE1_ENST00000586869.1_5'UTR|NLE1_ENST00000593176.1_5'UTR|NLE1_ENST00000360831.5_Silent_p.L46L	NM_001014445.1|NM_018096.3	NP_001014445.1|NP_060566.2	Q9NVX2	NLE1_HUMAN	notchless homolog 1 (Drosophila)	46						nucleolus				NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	22		Ovarian(249;0.17)				CGTTGCACACGAGCTGCAGCC	0.662000													3	5					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33276535	33276535	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:33276535C>G	ENST00000373477.4	-	2	1089	c.181G>C	c.(181-183)Gac>Cac	p.D61H		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	61					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	TTTAAGAAGTCTGCAATCTTT	0.493000													75	141					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103322387	103322387	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:103322387C>G	ENST00000233969.2	+	11	2202	c.2060C>G	c.(2059-2061)tCt>tGt	p.S687C		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	687						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						AGGACTATTTCTATTGCAGGT	0.299000													17	36					0	0	1	0	0
CBLB	868	broad.mit.edu	37	3	105464816	105464816	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:105464816G>A	ENST00000264122.4	-	6	1111	c.790C>T	c.(790-792)Ctc>Ttc	p.L264F	CBLB_ENST00000545639.1_3'UTR|CBLB_ENST00000403724.1_Missense_Mutation_p.L264F|CBLB_ENST00000405772.1_Missense_Mutation_p.L264F|CBLB_ENST00000394027.3_Missense_Mutation_p.L286F	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	264	Cbl-PTB.|SH2-like.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						TCATATGTGAGAAATGCCATG	0.343000			Mis S		AML								33	82					0	0	1	0	0
FDX1	2230	broad.mit.edu	37	11	110306560	110306560	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:110306560C>T	ENST00000260270.2	+	2	426	c.188C>T	c.(187-189)tCa>tTa	p.S63L		NM_004109.4	NP_004100.1	P10109	ADX_HUMAN	ferredoxin 1	63					electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|iron ion binding			lung(2)	2		all_cancers(61;1.59e-12)|all_epithelial(67;8.38e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;5.27e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0384)|Colorectal(284;0.228)	Mitotane(DB00648)	TTTTCCAGCTCAGAAGATAAA	0.318000													8	10					0	0	1	0	0
MAN1A1	4121	broad.mit.edu	37	6	119510944	119510944	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:119510944G>A	ENST00000368468.3	-	10	1872	c.1431C>T	c.(1429-1431)ttC>ttT	p.F477F		NM_005907.3	NP_005898.2	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	477					post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|skin(3)	24		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		TGCCCCCCGCGAAGCAGGTCA	0.567000													17	41					0	0	1	0	0
ZNF648	127665	broad.mit.edu	37	1	182025802	182025802	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:182025802G>C	ENST00000339948.3	-	2	1551	c.1344C>G	c.(1342-1344)ttC>ttG	p.F448L		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						CAGCGCACTTGAAAGGCCTCT	0.682000													3	16					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26423234	26423234	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:26423234G>C	ENST00000335473.7	+	43	7544	c.7294G>C	c.(7294-7296)Gac>Cac	p.D2432H	MYO18B_ENST00000536101.1_Missense_Mutation_p.D2432H|MYO18B_ENST00000407587.2_Missense_Mutation_p.D2433H	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2432						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity	p.D2433N(1)		NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCCAAGCCTCGACTACGAACG	0.562000													16	69					0	0	1	0	0
PARVB	29780	broad.mit.edu	37	22	44395509	44395509	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:44395509C>G	ENST00000406477.3	+	2	297	c.167C>G	c.(166-168)tCa>tGa	p.S56*		NM_001003828.2	NP_001003828.1	Q9HBI1	PARVB_HUMAN	parvin, beta	0					cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding			NS(1)|breast(1)|endometrium(3)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	25		Ovarian(80;0.0246)|all_neural(38;0.0423)				ctccctggctcagacaGATCA	0.562000													14	94					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76964702	76964702	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:76964702G>A	ENST00000380887.2	+	7	1275	c.1203G>A	c.(1201-1203)caG>caA	p.Q401Q	ESRRB_ENST00000261532.7_Silent_p.Q401Q|ESRRB_ENST00000509242.1_Silent_p.Q401Q|RP11-187O7.3_ENST00000554926.1_lincRNA|ESRRB_ENST00000556177.1_Silent_p.Q401Q			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	401						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		TGCTGCGGCAGACGGCCGCCA	0.622000													7	11					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157502141	157502141	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:157502141G>C	ENST00000346085.5	+	12	3175	c.3174G>C	c.(3172-3174)acG>acC	p.T1058T	ARID1B_ENST00000275248.4_Silent_p.T1040T|ARID1B_ENST00000478761.2_3'UTR|ARID1B_ENST00000367148.1_Silent_p.T1098T|ARID1B_ENST00000350026.5_Silent_p.T1045T	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1045	ARID.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		AGAAGATCACGAAGGTGTACG	0.572000													8	19					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75898184	75898184	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:75898184G>A	ENST00000322507.8	-	8	1200	c.891C>T	c.(889-891)ttC>ttT	p.F297F	COL12A1_ENST00000483888.2_Silent_p.F297F|COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000416123.2_Silent_p.F297F	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	297	VWFA 1.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TGGCCACATTGAAAACATGGT	0.398000													31	38					0	0	1	0	0
MARS2	92935	broad.mit.edu	37	2	198570649	198570649	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:198570649G>A	ENST00000282276.6	+	1	563	c.520G>A	c.(520-522)Gag>Aag	p.E174K	AC011997.1_ENST00000409845.1_Intron	NM_138395.3	NP_612404.1	Q96GW9	SYMM_HUMAN	methionyl-tRNA synthetase 2, mitochondrial	174					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	22					L-Methionine(DB00134)	CGCTTCCGACGAGTGCTTCCT	0.627000													23	45					0	0	1	0	0
USP39	10713	broad.mit.edu	37	2	85843553	85843553	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:85843553G>A	ENST00000323701.6	+	1	245	c.235G>A	c.(235-237)Gat>Aat	p.D79N	USP39_ENST00000459775.1_Intron|USP39_ENST00000409470.1_Missense_Mutation_p.D79N|USP39_ENST00000409766.3_Missense_Mutation_p.D79N|USP39_ENST00000409025.1_Missense_Mutation_p.D79N|USP39_ENST00000450066.2_Intron	NM_006590.3	NP_006581.2	Q53GS9	SNUT2_HUMAN	ubiquitin specific peptidase 39	79	Arg-rich.				spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	19						GCGCGAGGTCGATGAGGACTC	0.677000													5	5					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120599780	120599780	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:120599780G>T	ENST00000300648.6	-	21	2258	c.2246C>A	c.(2245-2247)tCc>tAc	p.S749Y		NM_006836.1	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	749					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTTCTGCACGGAGGCAGTGAT	0.592000													27	37					2.27525e-19	2.42197e-19	1	1	0
ITGA7	3679	broad.mit.edu	37	12	56088298	56088298	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:56088298G>C	ENST00000257880.7	-	18	2637	c.2418C>G	c.(2416-2418)ttC>ttG	p.F806L	ITGA7_ENST00000553804.1_Missense_Mutation_p.F766L|ITGA7_ENST00000452168.2_Missense_Mutation_p.F669L|ITGA7_ENST00000555728.1_Missense_Mutation_p.F806L|ITGA7_ENST00000347027.6_Missense_Mutation_p.F756L|ITGA7_ENST00000394229.2_Missense_Mutation_p.F762L|ITGA7_ENST00000257879.6_Missense_Mutation_p.F762L|ITGA7_ENST00000394230.2_Missense_Mutation_p.F766L			Q13683	ITA7_HUMAN	integrin, alpha 7	806					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GGATGAGGTAGAAGGTGACCT	0.577000													7	23					0	0	1	0	0
LCLAT1	253558	broad.mit.edu	37	2	30790973	30790973	+	Nonsense_Mutation	SNP	C	C	T	rs141543989		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:30790973C>T	ENST00000309052.4	+	6	882	c.673C>T	c.(673-675)Cag>Tag	p.Q225*	LCLAT1_ENST00000319406.4_Nonsense_Mutation_p.Q225*|LCLAT1_ENST00000359433.1_Nonsense_Mutation_p.Q225*|LCLAT1_ENST00000379509.3_Nonsense_Mutation_p.Q187*|LCLAT1_ENST00000540623.1_Nonsense_Mutation_p.Q187*|LCLAT1_ENST00000491680.2_3'UTR	NM_182551.3	NP_872357.2	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1	225					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)	19						AAATGGACTTCAGAAATATGA	0.318000													13	58					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	100964768	100964768	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:100964768G>C	ENST00000193391.7	-	12	1608	c.1421C>G	c.(1420-1422)tCt>tGt	p.S474C		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	474					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						CTCTGGGGAAGAGCTGAGGCC	0.522000													10	57					0	0	1	0	0
BRAP	8315	broad.mit.edu	37	12	112082359	112082359	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:112082359G>A	ENST00000419234.4	-	12	1616	c.1423C>T	c.(1423-1425)Cag>Tag	p.Q475*	BRAP_ENST00000539060.1_Nonsense_Mutation_p.Q296*|BRAP_ENST00000327551.6_Nonsense_Mutation_p.Q445*	NM_006768.3	NP_006759.3	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	475					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	20						GTGTTTAGCTGAGTGCACCTT	0.453000													40	86					0	0	1	0	0
SPOPL	339745	broad.mit.edu	37	2	139318471	139318471	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:139318471G>C	ENST00000280098.4	+	8	1190	c.811G>C	c.(811-813)Gac>Cac	p.D271H		NM_001001664.2	NP_001001664.1	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	271						nucleus				breast(2)|cervix(2)|endometrium(2)|large_intestine(2)|lung(11)|skin(2)	21				BRCA - Breast invasive adenocarcinoma(221;0.0296)		CAAAATGGCTGACAACTTGTT	0.358000													17	45					0	0	1	0	0
LHB	3972	broad.mit.edu	37	19	49519531	49519531	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:49519531G>A	ENST00000221421.2	-	3	219	c.220C>T	c.(220-222)Cag>Tag	p.Q74*		NM_000894.2	NP_000885.1	P01229	LSHB_HUMAN	luteinizing hormone beta polypeptide	74			Q -> R (in HGON-LHB; lack of receptor- binding; dbSNP:rs5030773).		cell-cell signaling|cellular nitrogen compound metabolic process|male gonad development|peptide hormone processing|progesterone biosynthetic process|signal transduction	extracellular region|soluble fraction	hormone activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Lutropin alfa(DB00044)|Menotropins(DB00032)	CACACCACCTGAGGCAGGGGC	0.677000													55	34					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	179966204	179966204	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:179966204G>A	ENST00000367607.3	+	6	1330	c.912G>A	c.(910-912)caG>caA	p.Q304Q		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	304						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						GCCGGGGCCAGAAGCTGGGTC	0.433000													35	84					0	0	1	0	0
FOXO3	2309	broad.mit.edu	37	6	108985271	108985271	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:108985271C>G	ENST00000406360.1	+	2	1578	c.1235C>G	c.(1234-1236)tCt>tGt	p.S412C	FOXO3_ENST00000540898.1_Missense_Mutation_p.S192C|FOXO3_ENST00000343882.6_Missense_Mutation_p.S412C	NM_001455.3	NP_001446.1	O43524	FOXO3_HUMAN	forkhead box O3	412					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		CAGCGGAGCTCTAGCTTCCCG	0.592000													23	51					0	0	1	0	0
C15orf48	84419	broad.mit.edu	37	15	45723015	45723015	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:45723015G>C	ENST00000344300.3	+	1	211	c.21G>C	c.(19-21)ctG>ctC	p.L7L	RP11-519G16.5_ENST00000559553.1_RNA|C15orf48_ENST00000396650.2_Silent_p.L7L	NM_032413.3	NP_115789.1	Q9C002	NMES1_HUMAN	chromosome 15 open reading frame 48	7						nucleus				large_intestine(1)|lung(2)|ovary(1)	4		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.67e-16)|GBM - Glioblastoma multiforme(94;1.71e-06)		TCCAACTCCTGATGAAAAGGA	0.343000											OREG0023107	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	36					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15729029	15729029	+	RNA	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:15729029C>T	ENST00000441682.2	+	0	407							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CCCAAAGCTTCTGTGCAGCTC	0.522000													18	18					0	0	1	0	0
MLF2	8079	broad.mit.edu	37	12	6858131	6858131	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:6858131C>G	ENST00000203630.5	-	8	1221	c.577G>C	c.(577-579)Gat>Cat	p.D193H	MLF2_ENST00000542154.1_Missense_Mutation_p.D193H|MLF2_ENST00000435120.1_Missense_Mutation_p.D193H|MLF2_ENST00000539187.1_Missense_Mutation_p.D193H			Q15773	MLF2_HUMAN	myeloid leukemia factor 2	193					defense response	cytoplasm|nucleus	protein binding			kidney(2)|large_intestine(3)|lung(4)	9						CACTCGTCATCAAACGCTGCG	0.677000													5	12					0	0	1	0	0
CPSF2	53981	broad.mit.edu	37	14	92601740	92601740	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:92601740C>T	ENST00000298875.4	+	6	730	c.445C>T	c.(445-447)Ctg>Ttg	p.L149L		NM_017437.2	NP_059133.1	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2, 100kDa	149					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	24		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		TATCACACCTCTGCCAGCTGG	0.368000													19	50					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107979390	107979390	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:107979390G>A	ENST00000372129.2	-	1	261	c.185C>T	c.(184-186)tCc>tTc	p.S62F	RP6-24A23.3_ENST00000608811.1_RNA	NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	62						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GTCTGACCGGGAGCCAGTGGC	0.652000													24	34					0	0	1	0	0
DTX3L	151636	broad.mit.edu	37	3	122287474	122287474	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:122287474G>A	ENST00000296161.4	+	3	727	c.538G>A	c.(538-540)Gac>Aac	p.D180N	DTX3L_ENST00000383661.3_Intron	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	180					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		TGACTTCCAAGACATTGAAAG	0.433000													16	42					0	0	1	0	0
TAAR1	134864	broad.mit.edu	37	6	132967038	132967038	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:132967038C>T	ENST00000275216.1	-	1	104	c.105G>A	c.(103-105)ctG>ctA	p.L35L		NM_138327.1	NP_612200.1	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	35						plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)	18	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	CGAGTGTGGTCAGAATTATGA	0.393000													45	76					0	0	1	0	0
ALX1	8092	broad.mit.edu	37	12	85674217	85674217	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:85674217G>C	ENST00000316824.3	+	1	333	c.178G>C	c.(178-180)Gag>Cag	p.E60Q		NM_006982.2	NP_008913.2	Q15699	ALX1_HUMAN	ALX homeobox 1	60					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|ovary(1)	26				GBM - Glioblastoma multiforme(134;0.134)		GCCCCGCGCCGAGCATCACGT	0.637000													17	29					0	0	1	0	0
SLC13A2	9058	broad.mit.edu	37	17	26816303	26816303	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:26816303C>T	ENST00000444914.3	+	2	594	c.174C>T	c.(172-174)gtC>gtT	p.V58V	SLC13A2_ENST00000545060.1_Intron|SLC13A2_ENST00000314669.5_Silent_p.V58V|SLC13A2_ENST00000537681.1_5'UTR	NM_001145975.1	NP_001139447.1	Q13183	S13A2_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	58						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CCCTGGCCGTCACTGCCCTCT	0.612000													11	22					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54581048	54581048	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:54581048G>A	ENST00000336470.4	+	14	1508	c.1369G>A	c.(1369-1371)Gaa>Aaa	p.E457K	GNL3L_ENST00000360845.2_Missense_Mutation_p.E457K	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	457					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						GGACCCACTTGAAATGGAGAT	0.493000													13	43					0	0	1	0	0
DNAI1	27019	broad.mit.edu	37	9	34517360	34517360	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:34517360C>G	ENST00000242317.4	+	19	2067	c.1896C>G	c.(1894-1896)ctC>ctG	p.L632L		NM_001281428.1|NM_012144.2	NP_001268357.1|NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	632					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		AGAACAGGCTCACCCACGTGC	0.537000									Kartagener syndrome				20	23					0	0	1	0	0
LZTS1	11178	broad.mit.edu	37	8	20107259	20107259	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:20107259C>G	ENST00000381569.1	-	4	2122	c.1765G>C	c.(1765-1767)Gag>Cag	p.E589Q	LZTS1_ENST00000265801.6_Missense_Mutation_p.E589Q|LZTS1_ENST00000522290.1_Missense_Mutation_p.E530Q			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	589					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		ATGATGTCCTCGTAGGGGATG	0.672000													18	39					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21551823	21551823	+	Missense_Mutation	SNP	C	C	T	rs140832903		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:21551823C>T	ENST00000415912.2	-	17	2037	c.1912G>A	c.(1912-1914)Gtg>Atg	p.V638M	ECE1_ENST00000357071.4_Missense_Mutation_p.V642M|ECE1_ENST00000436918.2_Missense_Mutation_p.V654M|ECE1_ENST00000374893.6_Missense_Mutation_p.V654M|ECE1_ENST00000264205.6_Missense_Mutation_p.V651M	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	654					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		TCCCCGTTCACGCTGTAGTTG	0.637000													16	35					0	0	1	0	0
PMPCB	9512	broad.mit.edu	37	7	102937979	102937979	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:102937979C>G	ENST00000249269.4	+	1	111	c.73C>G	c.(73-75)Ctt>Gtt	p.L25V	PMPCB_ENST00000428154.1_Missense_Mutation_p.L25V|PMPCB_ENST00000420236.2_5'UTR	NM_004279.2	NP_004270.2	O75439	MPPB_HUMAN	peptidase (mitochondrial processing) beta	25					proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding	p.L25V(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(9)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CAGCGAGAGTCTTCTAATCCG	0.662000											OREG0018240	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	18					0	0	1	0	0
ZNF75D	7626	broad.mit.edu	37	X	134427803	134427803	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:134427803G>A	ENST00000370766.3	-	3	2973	c.264C>T	c.(262-264)atC>atT	p.I88I	ZNF75D_ENST00000494295.1_Intron|ZNF75D_ENST00000370764.1_Silent_p.I88I	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	88	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						GCATTTCCAAGATCTGCTCTT	0.502000													22	49					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60885766	60885766	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:60885766G>C	ENST00000252999.3	-	75	10467	c.10401C>G	c.(10399-10401)ctC>ctG	p.L3467L		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3467	Laminin G-like 4.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGCCCACAAAGAGGGTGTGGG	0.697000													7	11					0	0	1	0	0
DDB2	1643	broad.mit.edu	37	11	47256432	47256432	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:47256432G>C	ENST00000256996.4	+	6	1022	c.827G>C	c.(826-828)aGa>aCa	p.R276T	DDB2_ENST00000378601.3_Intron|DDB2_ENST00000378600.3_Intron|DDB2_ENST00000378603.3_Missense_Mutation_p.R212T	NM_000107.2	NP_000098.1	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa	276					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						CGCCAGGTTAGAGGGAAAGCC	0.552000			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				13	28					0	0	1	0	0
PHF8	23133	broad.mit.edu	37	X	54014218	54014218	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:54014218C>T	ENST00000338154.6	-	15	2394	c.1890G>A	c.(1888-1890)gcG>gcA	p.A630A	PHF8_ENST00000357988.5_Silent_p.A666A|PHF8_ENST00000338946.6_Silent_p.A529A|PHF8_ENST00000322659.8_Silent_p.A630A	NM_015107.2	NP_055922.1	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	666					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	40						TTATCAGGGTCGCCTTCTCCT	0.453000													4	3					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55568475	55568475	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:55568475C>T	ENST00000395445.1	-	36	5729	c.5335G>A	c.(5335-5337)Gaa>Aaa	p.E1779K	PCDH15_ENST00000395440.1_Missense_Mutation_p.E713K|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395442.1_Missense_Mutation_p.E644K|PCDH15_ENST00000395446.1_Missense_Mutation_p.E975K|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000395438.1_3'UTR	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTGTAACCTTCAGAGTTTGCT	0.478000										HNSCC(58;0.16)			5	25					0	0	1	0	0
MFSD2B	388931	broad.mit.edu	37	2	24236213	24236213	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:24236213T>G	ENST00000338315.4	+	2	155	c.155T>G	c.(154-156)gTc>gGc	p.V52G	MFSD2B_ENST00000406420.3_Missense_Mutation_p.V52G			A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing 2B	52					transport	integral to membrane				cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10						ATTGGTGGGGTCCCCAACCAG	0.557000													10	24					0	0	1	0	0
ZNF654	55279	broad.mit.edu	37	3	88188699	88188699	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:88188699C>T	ENST00000309495.5	+	1	446	c.239C>T	c.(238-240)tCa>tTa	p.S80L	CGGBP1_ENST00000462901.1_Intron	NM_018293.2	NP_060763.2	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	80	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(1)|ovary(2)|pancreas(1)|prostate(3)	12		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TCTTCCATTTCATTTGAAAAT	0.398000													12	27					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39229889	39229889	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:39229889C>G	ENST00000340369.3	-	2	1276	c.1048G>C	c.(1048-1050)Gag>Cag	p.E350Q	XIRP1_ENST00000396251.1_Missense_Mutation_p.E350Q|XIRP1_ENST00000421646.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	350							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GCTCGGGTCTCAAACAGATGC	0.597000													48	100					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61034934	61034934	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:61034934C>T	ENST00000335613.5	-	16	2351	c.1965G>A	c.(1963-1965)ctG>ctA	p.L655L	VWCE_ENST00000535710.1_Splice_Site_p.L120L	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	655	VWFC 5.					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						TGGTCCATACCAGGCAGATGC	0.557000													11	32					0	0	1	0	0
TRBV6-8	28599	broad.mit.edu	37	7	142124551	142124551	+	RNA	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:142124551G>A	ENST00000390376.2	-	0	14																											CACAGCACAGGAGCCCGAGGC	0.607000													30	92					0	0	1	0	0
PLD3	23646	broad.mit.edu	37	19	40883925	40883925	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:40883925G>A	ENST00000409587.1	+	13	1715	c.1318G>A	c.(1318-1320)Gag>Aag	p.E440K	PLD3_ENST00000409281.1_Missense_Mutation_p.E440K|PLD3_ENST00000356508.5_Missense_Mutation_p.E440K|PLD3_ENST00000409419.1_Missense_Mutation_p.E440K|PLD3_ENST00000409735.4_Missense_Mutation_p.E440K			Q8IV08	PLD3_HUMAN	phospholipase D family, member 3	440					lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			CTACTTCACGGAGACGGCGGG	0.642000													14	63					0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149751792	149751792	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:149751792G>A	ENST00000451292.1	+	7	971	c.863G>A	c.(862-864)cGa>cAa	p.R288Q	TCOF1_ENST00000513346.1_Missense_Mutation_p.R288Q|TCOF1_ENST00000323668.7_Intron|TCOF1_ENST00000394269.3_Missense_Mutation_p.R288Q|TCOF1_ENST00000504761.2_Missense_Mutation_p.R288Q|TCOF1_ENST00000377797.3_Missense_Mutation_p.R288Q|TCOF1_ENST00000439160.2_Missense_Mutation_p.R288Q|TCOF1_ENST00000445265.2_Intron			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	288					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAGGGACACGAAGCCAGGTG	0.652000													7	4					0	0	1	0	0
COG2	22796	broad.mit.edu	37	1	230778413	230778413	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:230778413G>A	ENST00000366669.4	+	1	176	c.61G>A	c.(61-63)Gag>Aag	p.E21K	COG2_ENST00000366668.3_Missense_Mutation_p.E21K|COG2_ENST00000535166.1_5'UTR	NM_001145036.1|NM_007357.2	NP_001138508.1|NP_031383.1	Q14746	COG2_HUMAN	component of oligomeric golgi complex 2	21					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity			NS(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|urinary_tract(3)	27	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				CGACAAGGACGAGTTCATGAA	0.662000													3	9					0	0	1	0	0
SPATA32	124783	broad.mit.edu	37	17	43333102	43333102	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:43333102G>A	ENST00000543122.1	-	6	1165	c.384C>T	c.(382-384)atC>atT	p.I128I	MAP3K14-AS1_ENST00000585346.1_RNA|MAP3K14-AS1_ENST00000592422.1_RNA|MAP3K14-AS1_ENST00000588698.1_RNA|MAP3K14-AS1_ENST00000590100.1_RNA|MAP3K14-AS1_ENST00000591263.1_RNA|MAP3K14-AS1_ENST00000588160.1_RNA|SPATA32_ENST00000331780.4_Silent_p.I149I|MAP3K14-AS1_ENST00000588504.1_RNA					spermatogenesis associated 32																		TCTGCGCACTGATGGAGTGAT	0.582000													24	53					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55175632	55175632	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:55175632G>C	ENST00000421030.2	+	24	4029	c.3744G>C	c.(3742-3744)ttG>ttC	p.L1248F	MROH7_ENST00000454855.2_Missense_Mutation_p.L766F|MROH7_ENST00000409996.1_Missense_Mutation_p.L816F|MROH7-TTC4_ENST00000414150.2_Intron	NM_001039464.2	NP_001034553			maestro heat-like repeat family member 7									p.L1245F(1)|p.L1248F(1)									TGGATAACTTGAGACATGACC	0.567000													15	38					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73636358	73636358	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:73636358C>T	ENST00000377687.4	+	2	1157	c.621C>T	c.(619-621)ttC>ttT	p.F207F	KLF5_ENST00000539231.1_Silent_p.F116F|KLF5_ENST00000477333.1_3'UTR	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	207					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		ACAATATTTTCATCAAACAAG	0.527000													15	32					0	0	1	0	0
EML4	27436	broad.mit.edu	37	2	42543170	42543170	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:42543170C>T	ENST00000318522.5	+	18	2298	c.2036C>T	c.(2035-2037)tCt>tTt	p.S679F	EML4_ENST00000401738.3_Missense_Mutation_p.S690F|EML4_ENST00000453191.2_Intron|EML4_ENST00000402711.2_Missense_Mutation_p.S621F	NM_019063.3	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	679					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						GAACAGCTCTCTGTGATGCGC	0.408000			T	ALK	NSCLC								20	56					0	0	1	0	0
TRIM50	135892	broad.mit.edu	37	7	72738498	72738498	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:72738498G>C	ENST00000333149.2	-	2	488	c.288C>G	c.(286-288)ctC>ctG	p.L96L	TRIM50_ENST00000453152.1_Silent_p.L96L|TRIM50_ENST00000493498.1_5'UTR	NM_178125.2	NP_835226.2	Q86XT4	TRI50_HUMAN	tripartite motif containing 50	96						cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)	20						AGAAAAGGCTGAGCGGGTTCC	0.667000											OREG0018105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	93					0	0	1	0	0
OSBPL9	114883	broad.mit.edu	37	1	52246873	52246873	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:52246873C>G	ENST00000371710.3	+	16	1530	c.1348C>G	c.(1348-1350)Cag>Gag	p.Q450E	OSBPL9_ENST00000371714.1_Missense_Mutation_p.Q419E|OSBPL9_ENST00000530544.1_Missense_Mutation_p.Q351E|OSBPL9_ENST00000435686.2_Missense_Mutation_p.Q267E|OSBPL9_ENST00000453295.1_Missense_Mutation_p.Q415E|OSBPL9_ENST00000337809.4_Missense_Mutation_p.Q437E|OSBPL9_ENST00000428468.1_Missense_Mutation_p.Q432E|OSBPL9_ENST00000361556.5_Missense_Mutation_p.Q322E|OSBPL9_ENST00000531828.1_Missense_Mutation_p.Q267E|OSBPL9_ENST00000462759.1_Missense_Mutation_p.Q254E|OSBPL9_ENST00000447887.1_Missense_Mutation_p.Q442E|OSBPL9_ENST00000486942.1_Missense_Mutation_p.Q254E	NM_024586.5|NM_148906.2	NP_078862.4|NP_683704.2	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9	432					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|pancreas(1)|prostate(3)|skin(1)	18						TCGAATGGTTCAGGTTGTGAA	0.438000													8	35					0	0	1	0	0
PUM2	23369	broad.mit.edu	37	2	20507824	20507824	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:20507824C>T	ENST00000361078.2	-	6	820	c.798G>A	c.(796-798)caG>caA	p.Q266Q	PUM2_ENST00000319801.5_Silent_p.Q266Q|PUM2_ENST00000403432.1_Silent_p.Q266Q|PUM2_ENST00000338086.5_Silent_p.Q266Q|PUM2_ENST00000536417.1_Silent_p.Q210Q			Q8TB72	PUM2_HUMAN	pumilio RNA-binding family member 2	266					regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(7)|lung(13)|ovary(2)|prostate(4)|urinary_tract(3)	42	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATTAGTCCTCTGAAAGAGCT	0.338000													15	49					0	0	1	0	0
DISC1	27185	broad.mit.edu	37	1	231830283	231830283	+	Missense_Mutation	SNP	G	G	C	rs149702548		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:231830283G>C	ENST00000439617.2	+	2	832	c.779G>C	c.(778-780)cGa>cCa	p.R260P	DISC1_ENST00000537876.1_Missense_Mutation_p.R260P|DISC1_ENST00000539444.1_Missense_Mutation_p.R260P|DISC1_ENST00000366633.3_Missense_Mutation_p.R260P|DISC1_ENST00000366636.4_Missense_Mutation_p.R260P|DISC1_ENST00000535983.1_Missense_Mutation_p.R260P|DISC1_ENST00000602281.1_Missense_Mutation_p.R260P|DISC1_ENST00000317586.4_Missense_Mutation_p.R260P|DISC1_ENST00000366637.3_5'UTR|DISC1_ENST00000602873.1_Intron|TSNAX-DISC1_ENST00000602962.1_3'UTR	NM_001164537.1|NM_001164540.1|NM_018662.2	NP_001158009.1|NP_001158012.1|NP_061132.2	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1	260	Interaction with MAP1A.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			breast(1)|cervix(1)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(173;0.0208)|Prostate(94;0.0975)				GAGGACCCGCGATGTCTCTCT	0.627000													23	39					0	0	1	0	0
NCOA7	135112	broad.mit.edu	37	6	126210086	126210086	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:126210086G>A	ENST00000368357.3	+	10	1238	c.886G>A	c.(886-888)Gac>Aac	p.D296N	NCOA7_ENST00000229634.9_Intron|NCOA7_ENST00000392477.2_Splice_Site_p.D296N	NM_001199619.1|NM_001199620.1	NP_001186548.1|NP_001186549.1	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7	296					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(2)	39				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		CCCCAACAGTGACCTACCTCA	0.403000													37	90					0	0	1	0	0
FAM3D	131177	broad.mit.edu	37	3	58629415	58629415	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:58629415C>T	ENST00000358781.2	-	6	606	c.296G>A	c.(295-297)aGa>aAa	p.R99K		NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	99					negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		GTTTAGGCCTCTGCCCACATT	0.512000													12	76					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35391834	35391834	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:35391834C>G	ENST00000311565.4	+	7	885	c.536C>G	c.(535-537)tCc>tGc	p.S179C	PPARD_ENST00000360694.3_Missense_Mutation_p.S179C|PPARD_ENST00000448077.2_Missense_Mutation_p.S140C|PPARD_ENST00000444397.1_Missense_Mutation_p.S179C|PPARD_ENST00000337400.2_Missense_Mutation_p.S179C|PPARD_ENST00000540939.1_Missense_Mutation_p.S76C|PPARD_ENST00000418635.2_Missense_Mutation_p.S81C	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	179					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	AAGGCCTTCTCCAAGCACATC	0.577000													21	42					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57868242	57868242	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:57868242C>T	ENST00000393797.2	-	18	2209	c.2017G>A	c.(2017-2019)Gat>Aat	p.D673N	ARHGAP9_ENST00000393791.3_Missense_Mutation_p.D583N|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.D583N|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.D602N|ARHGAP9_ENST00000550288.1_Missense_Mutation_p.D662N|ARHGAP9_ENST00000430041.2_Missense_Mutation_p.D399N			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	602	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			TACCTCCCATCGGAGGTGACC	0.512000													12	29					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31737399	31737399	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:31737399C>T	ENST00000215919.3	-	3	1779	c.1606G>A	c.(1606-1608)Gtt>Att	p.V536I	PATZ1_ENST00000266269.5_Intron|PATZ1_ENST00000351933.4_Intron|PATZ1_ENST00000405309.3_Intron	NM_032051.1	NP_114440.1	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	0					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						GGCTAGCCAACAGGCCACTGG	0.637000													28	51					0	0	1	0	0
CASP1	834	broad.mit.edu	37	11	104905127	104905127	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:104905127C>T	ENST00000533400.1	-	2	117	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	CASP1_ENST00000531166.1_Intron|CASP1_ENST00000598974.1_Missense_Mutation_p.E28K|CASP1_ENST00000594519.1_Intron|CASP1_ENST00000593315.1_Missense_Mutation_p.E28K|CASP1_ENST00000446369.1_Intron|CASP1_ENST00000415981.2_Intron|CASP1_ENST00000534497.1_Intron|CASP1_ENST00000527979.1_Missense_Mutation_p.E12K|CASP1_ENST00000436863.3_Missense_Mutation_p.E28K|CASP1_ENST00000526568.1_Intron|CASP1_ENST00000528974.1_Intron|CASP1_ENST00000525825.1_Missense_Mutation_p.E28K|CASP1_ENST00000393136.4_Missense_Mutation_p.E28K|CASP1_ENST00000353247.5_Intron	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	28	CARD.				cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TGTAATAATTCATCCAGTAAG	0.418000													65	147					0	0	1	0	0
STRA8	346673	broad.mit.edu	37	7	134939929	134939929	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:134939929C>T	ENST00000275764.3	+	8	870	c.870C>T	c.(868-870)atC>atT	p.I290I		NM_182489.1	NP_872295.1	Q7Z7C7	STRA8_HUMAN	stimulated by retinoic acid 8	290					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|urinary_tract(1)	16						ATATGCAGATCATCAACTTTT	0.453000													35	84					0	0	1	0	0
FOXO3	2309	broad.mit.edu	37	6	108985623	108985623	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:108985623C>T	ENST00000406360.1	+	2	1930	c.1587C>T	c.(1585-1587)gtC>gtT	p.V529V	FOXO3_ENST00000540898.1_Silent_p.V309V|FOXO3_ENST00000343882.6_Silent_p.V529V	NM_001455.3	NP_001446.1	O43524	FOXO3_HUMAN	forkhead box O3	529					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		GAAGTTTGGTCAATCAGAACT	0.567000													26	45					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189855742	189855742	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:189855742C>T	ENST00000304636.3	+	11	981	c.811C>T	c.(811-813)Cga>Tga	p.R271*	COL3A1_ENST00000317840.5_Nonsense_Mutation_p.R271*	NM_000090.3	NP_000081	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	271	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTTCGATGGACGAAATGGAGA	0.284000													23	82					0	0	1	0	0
ZNF75D	7626	broad.mit.edu	37	X	134424953	134424953	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:134424953C>G	ENST00000370766.3	-	6	3514	c.805G>C	c.(805-807)Gag>Cag	p.E269Q	ZNF75D_ENST00000494295.1_Intron|ZNF75D_ENST00000370764.1_Missense_Mutation_p.E174Q	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	269	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						ATGACAGTCTCATAGATATCC	0.378000													42	86					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38133224	38133224	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:38133224C>G	ENST00000317025.8	-	24	4766	c.4249G>C	c.(4249-4251)Gaa>Caa	p.E1417Q	WHSC1L1_ENST00000527502.1_Missense_Mutation_p.E1406Q|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.E1368Q	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	1417					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			CTCCAGTATTCTGGTGACACA	0.448000			T	NUP98	AML								11	27					0	0	1	0	0
SSH3	54961	broad.mit.edu	37	11	67071613	67071613	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:67071613C>G	ENST00000308127.4	+	2	269	c.91C>G	c.(91-93)Cga>Gga	p.R31G	SSH3_ENST00000308298.7_Missense_Mutation_p.R31G|SSH3_ENST00000376757.5_Missense_Mutation_p.R31G|SSH3_ENST00000532181.1_3'UTR	NM_017857.3	NP_060327.3	Q8TE77	SSH3_HUMAN	slingshot protein phosphatase 3	31					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GCGAAGGAGTCGACTCCAGCG	0.687000													3	6					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111696185	111696185	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:111696185G>C	ENST00000435970.1	-	15	3955	c.3139C>G	c.(3139-3141)Cca>Gca	p.P1047A	REV3L_ENST00000368805.1_Missense_Mutation_p.P1125A|REV3L_ENST00000358835.3_Missense_Mutation_p.P1125A|REV3L_ENST00000368802.3_Missense_Mutation_p.P1125A			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1125					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CAGCGAGGTGGAGAAGAATTT	0.403000								DNA polymerases (catalytic subunits)					31	110					0	0	1	0	0
USP6NL	9712	broad.mit.edu	37	10	11504817	11504817	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:11504817C>T	ENST00000609104.1	-	15	2504	c.2110G>A	c.(2110-2112)Gac>Aac	p.D704N	USP6NL_ENST00000379237.2_Missense_Mutation_p.D727N|USP6NL_ENST00000277575.5_Missense_Mutation_p.D721N	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like							intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						GCACCAGTGTCAACAGGGAGG	0.493000													3	32					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57599381	57599381	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:57599381C>G	ENST00000243077.3	+	75	11977	c.11511C>G	c.(11509-11511)ctC>ctG	p.L3837L		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3837	EGF-like 15.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCTCCCAGCTCTGCAACAACA	0.622000													20	36					0	0	1	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26157185	26157185	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:26157185G>A	ENST00000304218.3	+	1	627	c.567G>A	c.(565-567)gcG>gcA	p.A189A		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	189					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						AGAGCCCAGCGAAGGCCAAAG	0.547000													10	15					0	0	1	0	0
CC2D2B	387707	broad.mit.edu	37	10	97778996	97778996	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr10:97778996G>A	ENST00000344386.3	+	7	723	c.559G>A	c.(559-561)Gaa>Aaa	p.E187K	ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1-AS1_ENST00000454638.1_RNA|RP11-690P14.4_ENST00000475252.2_Intron|ENTPD1-AS1_ENST00000451364.1_RNA|ENTPD1-AS1_ENST00000458228.1_RNA|CC2D2B_ENST00000410012.2_Missense_Mutation_p.E187K|ENTPD1-AS1_ENST00000452728.1_RNA|CC2D2B_ENST00000371198.2_Intron	NM_001001732.3	NP_001001732.2	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B	187										large_intestine(1)|lung(7)|ovary(1)|urinary_tract(1)	10		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		AGAAACTAATGAATATTTGCT	0.308000													9	69					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34778681	34778681	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:34778681C>G	ENST00000338074.2	+	11	1423	c.1262C>G	c.(1261-1263)tCc>tGc	p.S421C	EPB41L1_ENST00000441639.1_Missense_Mutation_p.S359C|EPB41L1_ENST00000373941.1_Missense_Mutation_p.S421C|EPB41L1_ENST00000202028.5_Missense_Mutation_p.S359C|EPB41L1_ENST00000373950.2_Missense_Mutation_p.S324C|EPB41L1_ENST00000373946.3_Missense_Mutation_p.S390C	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	421					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					GAGCGTTCTTCCAGCAAACGG	0.617000													9	28					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38194862	38194862	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr8:38194862C>G	ENST00000317025.8	-	4	1388	c.871G>C	c.(871-873)Gat>Cat	p.D291H	WHSC1L1_ENST00000316985.3_Missense_Mutation_p.D291H|RP11-513D5.2_ENST00000527912.1_RNA|WHSC1L1_ENST00000527502.1_Missense_Mutation_p.D291H|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.D291H	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	291	PWWP 1.				cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			AGCTGGGGATCACTTGAAACC	0.408000			T	NUP98	AML								22	50					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50661265	50661265	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:50661265G>C	ENST00000371824.1	+	5	798	c.541G>C	c.(541-543)Gat>Cat	p.D181H	ELAVL4_ENST00000371821.1_Missense_Mutation_p.D186H|ELAVL4_ENST00000371823.4_Missense_Mutation_p.D181H|ELAVL4_ENST00000357083.4_Missense_Mutation_p.D198H|ELAVL4_ENST00000371819.1_Missense_Mutation_p.D186H|ELAVL4_ENST00000371827.1_Missense_Mutation_p.D181H|ELAVL4_ENST00000448907.2_Missense_Mutation_p.D184H			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	181	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding	p.D198N(1)|p.D181N(1)		NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						CATCCGCTTTGATAAGAGGAT	0.498000													25	52					0	0	1	0	0
NUP93	9688	broad.mit.edu	37	16	56852645	56852645	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:56852645C>T	ENST00000564887.1	+	4	819	c.190C>T	c.(190-192)Cgg>Tgg	p.R64W	NUP93_ENST00000542526.1_Missense_Mutation_p.R64W|NUP93_ENST00000308159.5_Missense_Mutation_p.R187W|NUP93_ENST00000569842.1_Missense_Mutation_p.R187W	NM_001242795.1	NP_001229724.1	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	187					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						GGCCTATGCGCGGCAAGTGAG	0.443000													7	46					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123087421	123087421	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:123087421C>G	ENST00000333479.7	+	47	5048	c.4871C>G	c.(4870-4872)tCg>tGg	p.S1624W	KNTC1_ENST00000450485.2_Intron|KNTC1_ENST00000436959.3_5'UTR|KNTC1_ENST00000537348.1_Missense_Mutation_p.S49W	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1624					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CTCTTAATTTCGAAATTAATG	0.333000													26	47					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119952798	119952798	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:119952798G>C	ENST00000307142.4	+	4	3064	c.2868G>C	c.(2866-2868)aaG>aaC	p.K956N	SYNPO2_ENST00000434046.2_Missense_Mutation_p.K956N|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000429713.2_Missense_Mutation_p.K956N	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	956						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						AAAAGGGAAAGAAACCCCTCA	0.502000													12	28					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	A	G	rs144273946	by1000genomes	TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:197348674A>G	ENST00000418868.1	-	0	585					NR_003266.2																						GGCTCTGTCCACCAAATGCAC	0.478000													3	75					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207162057	207162057	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:207162057G>C	ENST00000374423.3	+	4	534	c.148G>C	c.(148-150)Gat>Cat	p.D50H		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	50							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TTTCTTACAGGATGTACTGCA	0.378000													24	58					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33172768	33172768	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:33172768C>T	ENST00000404816.2	+	1	730	c.377C>T	c.(376-378)cCg>cTg	p.P126L	LTBP1_ENST00000354476.3_Missense_Mutation_p.P126L			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	126	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GGCGGCCACCCGGCAGCCGCC	0.751000													5	11					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156640349	156640349	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:156640349C>T	ENST00000368223.3	-	4	3763	c.3631G>A	c.(3631-3633)Gag>Aag	p.E1211K		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1211	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ACATCCTCCTCAGCTTCCTCT	0.642000													39	60					0	0	1	0	0
USP40	55230	broad.mit.edu	37	2	234402138	234402138	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:234402138C>G	ENST00000251722.6	-	25	2964	c.2847G>C	c.(2845-2847)gaG>gaC	p.E949D	USP40_ENST00000450966.1_Missense_Mutation_p.E961D|USP40_ENST00000427112.2_Missense_Mutation_p.E949D|USP40_ENST00000409945.1_Missense_Mutation_p.E125D			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	949					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CCTGATGACTCTCCCAGTGTC	0.517000													11	21					0	0	1	0	0
FER1L5	90342	broad.mit.edu	37	2	97368024	97368024	+	RNA	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:97368024C>G	ENST00000457909.1	+	0	4662							A0AVI2	FR1L5_HUMAN	fer-1-like 5 (C. elegans)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						AGCAAAGCCTCAGAGCACAGT	0.557000													9	7					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211192488	211192488	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:211192488G>A	ENST00000367007.4	-	6	838	c.669C>T	c.(667-669)atC>atT	p.I223I	KCNH1_ENST00000271751.4_Silent_p.I223I	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	223					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AGATCAAGATGATCCAATCCC	0.458000													48	58					0	0	1	0	0
ASCC2	84164	broad.mit.edu	37	22	30186466	30186466	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:30186466G>A	ENST00000397771.2	-	20	2271	c.2094C>T	c.(2092-2094)gcC>gcT	p.A698A	ASCC2_ENST00000542393.1_Silent_p.A622A|ASCC2_ENST00000307790.3_Silent_p.A698A			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	698					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			ACCCTTTCTTGGCGAGAAAGG	0.597000													4	29					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81746939	81746939	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:81746939C>T	ENST00000550584.2	-	16	2248	c.1953G>A	c.(1951-1953)atG>atA	p.M651I	PPFIA2_ENST00000549396.1_Missense_Mutation_p.M651I|PPFIA2_ENST00000443686.3_Missense_Mutation_p.M552I|PPFIA2_ENST00000541017.1_5'UTR|PPFIA2_ENST00000541570.2_Missense_Mutation_p.M218I|PPFIA2_ENST00000333447.7_Missense_Mutation_p.M633I|PPFIA2_ENST00000552948.1_Missense_Mutation_p.M651I|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Missense_Mutation_p.M633I|PPFIA2_ENST00000548586.1_Missense_Mutation_p.M651I|PPFIA2_ENST00000550359.2_Missense_Mutation_p.M498I|PPFIA2_ENST00000407050.4_Missense_Mutation_p.M577I	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	577										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						CCTGAAGCATCATGGCTAGCG	0.378000													5	58					0	0	1	0	0
BSDC1	55108	broad.mit.edu	37	1	32841956	32841956	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:32841956C>G	ENST00000341071.7	-	9	1125	c.1114G>C	c.(1114-1116)Gag>Cag	p.E372Q	BSDC1_ENST00000446293.2_Missense_Mutation_p.E372Q|BSDC1_ENST00000419121.2_Missense_Mutation_p.E299Q|BSDC1_ENST00000526031.1_Missense_Mutation_p.E260Q|BSDC1_ENST00000455895.2_Missense_Mutation_p.E355Q|BSDC1_ENST00000413080.1_Missense_Mutation_p.E294Q|BSDC1_ENST00000449308.1_Missense_Mutation_p.E355Q			Q9NW68	BSDC1_HUMAN	BSD domain containing 1	355							protein binding			breast(1)|central_nervous_system(2)|kidney(1)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CTCAGAGTCTCTACTCTGGCT	0.597000													40	82					0	0	1	0	0
PYROXD1	79912	broad.mit.edu	37	12	21621599	21621599	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:21621599G>C	ENST00000538582.1	+	12	1954	c.1201G>C	c.(1201-1203)Gaa>Caa	p.E401Q	PYROXD1_ENST00000240651.9_Missense_Mutation_p.E472Q			Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 1	472							oxidoreductase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|soft_tissue(1)	18						AGAAACATTTGAAAACCTAAT	0.328000													13	26					0	0	1	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24931552	24931552	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:24931552G>A	ENST00000289968.6	-	20	2614	c.2545C>T	c.(2545-2547)Cgc>Tgc	p.R849C	ARHGAP17_ENST00000303665.5_Missense_Mutation_p.R771C|ARHGAP17_ENST00000441763.2_3'UTR	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	849					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		AAGATGCTGCGATGCGGTTCT	0.542000													36	57					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127645795	127645795	+	Missense_Mutation	SNP	C	C	G	rs148303505		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:127645795C>G	ENST00000508053.1	-	46	6054	c.5080G>C	c.(5080-5082)Gat>Cat	p.D1694H	FBN2_ENST00000262464.4_Missense_Mutation_p.D1694H			P35556	FBN2_HUMAN	fibrillin 2	1694	EGF-like 28; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AAACACTCATCAATATCTAGA	0.378000													10	44					0	0	1	0	0
SLC25A24	29957	broad.mit.edu	37	1	108724616	108724616	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:108724616G>A	ENST00000565488.1	-	3	564	c.345C>T	c.(343-345)ctC>ctT	p.L115L	SLC25A24_ENST00000370041.4_Silent_p.L96L	NM_013386.4	NP_037518.3	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24	115	EF-hand 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		CCAGTGTCTGGAGAGACTGGA	0.338000													15	27					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72829014	72829014	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:72829014G>A	ENST00000268489.5	-	9	8239	c.7567C>T	c.(7567-7569)Cta>Tta	p.L2523L	ZFHX3_ENST00000397992.5_Silent_p.L1609L	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2523					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TGAGGAGGTAGGTTTGCGAGC	0.582000													13	83					0	0	1	0	0
ABL2	27	broad.mit.edu	37	1	179089340	179089340	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:179089340G>A	ENST00000502732.1	-	6	1233	c.1030C>T	c.(1030-1032)Ctg>Ttg	p.L344L	ABL2_ENST00000507173.1_Silent_p.L323L|ABL2_ENST00000504405.1_Silent_p.L308L|ABL2_ENST00000367623.4_Silent_p.L323L|ABL2_ENST00000392043.3_Silent_p.L323L|ABL2_ENST00000408940.3_Silent_p.L308L|ABL2_ENST00000344730.3_Silent_p.L329L|ABL2_ENST00000512653.1_Silent_p.L329L|ABL2_ENST00000511413.1_Silent_p.L344L	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	344	Protein kinase.			NL -> TI (in Ref. 8; no nucleotide entry).	axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	AGTTGTACCAGATTAGGATGC	0.378000			T	ETV6	AML								39	104					0	0	1	0	0
ZCCHC9	84240	broad.mit.edu	37	5	80608381	80608381	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:80608381G>A	ENST00000254037.2	+	5	3871	c.716G>A	c.(715-717)gGt>gAt	p.G239D	ZCCHC9_ENST00000380199.5_Missense_Mutation_p.G239D|ZCCHC9_ENST00000407610.3_Missense_Mutation_p.G239D|ZCCHC9_ENST00000506458.1_3'UTR|ZCCHC9_ENST00000438268.2_Missense_Mutation_p.G239D			Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9	239							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)	13		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)		GTCACAGTTGGTCGCTGGGCA	0.363000													30	19					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180885771	180885771	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:180885771G>A	ENST00000367588.4	+	2	587	c.532G>A	c.(532-534)Gag>Aag	p.E178K		NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	178										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						CCCTGGACGTGAGTACTGCAA	0.642000													10	79					0	0	1	0	0
SLC38A11	151258	broad.mit.edu	37	2	165809275	165809275	+	Translation_Start_Site	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:165809275C>G	ENST00000303735.4	-	2	333	c.3G>C	c.(1-3)atG>atC	p.M1I	SLC38A11_ENST00000409149.3_Start_Codon_SNP_p.M1I|SLC38A11_ENST00000409662.1_Start_Codon_SNP_p.M1I|SLC38A11_ENST00000409058.1_Intron	NM_173512.2	NP_775783.1	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	1					amino acid transport|sodium ion transport	integral to membrane				endometrium(2)|large_intestine(4)|lung(8)|ovary(1)	15						CAGCTTGCTTCATTGAATAAG	0.343000													31	46					0	0	1	0	0
RBM26	64062	broad.mit.edu	37	13	79911419	79911419	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:79911419G>A	ENST00000438737.2	-	19	2991	c.2551C>T	c.(2551-2553)Ctt>Ttt	p.L851F	RBM26_ENST00000267229.7_Missense_Mutation_p.L824F|RBM26_ENST00000438724.1_Missense_Mutation_p.L827F			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	851					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		CCAGATGAAAGAATCCCTCGT	0.517000													27	35					0	0	1	0	0
AGO4	192670	broad.mit.edu	37	1	36306946	36306946	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:36306946C>G	ENST00000373210.3	+	14	2150	c.1905C>G	c.(1903-1905)ctC>ctG	p.L635L		NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		AAGAGCTCCTCTACAGTCAAG	0.542000													20	28					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18305794	18305794	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr22:18305794C>T	ENST00000441493.2	-	23	3578	c.3226G>A	c.(3226-3228)Gtg>Atg	p.V1076M		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1076	Glu-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		TCTGAGTCCACATCTTCCTCT	0.567000													12	20					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51613044	51613044	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:51613044G>T	ENST00000371117.3	-	58	9645	c.9370C>A	c.(9370-9372)Cat>Aat	p.H3124N	PKHD1_ENST00000340994.4_Missense_Mutation_p.H3124N	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3124			H -> Y (in ARPKD).		cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					AGACTTGAATGCGCCACATTG	0.483000													11	253					5.50884e-06	5.6091e-06	1	1	0
CHD3	1107	broad.mit.edu	37	17	7793025	7793025	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr17:7793025G>C	ENST00000380358.4	+	2	322	c.321G>C	c.(319-321)aaG>aaC	p.K107N	CHD3_ENST00000330494.7_Missense_Mutation_p.K48N|CHD3_ENST00000358181.4_Missense_Mutation_p.K48N	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	48					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				TGGGTGTGAAGAAGAGAAAAC	0.483000													7	13					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142640112	142640112	+	Silent	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:142640112G>C	ENST00000355265.2	-	17	2265	c.1791C>G	c.(1789-1791)ctC>ctG	p.L597L		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	597			L -> P (in KEL6/Js(a) antigen; dbSNP:rs8176038).		proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TGTCACAGGCGAGGCAGCCCC	0.537000													19	45					0	0	1	0	0
COX7A2	1347	broad.mit.edu	37	6	75953512	75953512	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:75953512G>A	ENST00000370081.2	-	2	345	c.35C>T	c.(34-36)cCg>cTg	p.P12L	COX7A2_ENST00000230459.4_5'UTR|COX7A2_ENST00000370089.2_Missense_Mutation_p.P12L			P14406	CX7A2_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 2 (liver)	0						mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity			kidney(2)|lung(1)	3						TGGCCACGCCGGAACCGGAAC	0.522000													14	58					0	0	1	0	0
QDPR	5860	broad.mit.edu	37	4	17513587	17513587	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:17513587G>A	ENST00000281243.5	-	1	270	c.91C>T	c.(91-93)Cgg>Tgg	p.R31W	QDPR_ENST00000508623.1_Missense_Mutation_p.R31W|QDPR_ENST00000513615.1_Missense_Mutation_p.R31W|QDPR_ENST00000428702.2_Missense_Mutation_p.R31W	NM_000320.2	NP_000311.2	P09417	DHPR_HUMAN	quinoid dihydropteridine reductase	31					dihydrobiopterin metabolic process|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process	cytosol	6,7-dihydropteridine reductase activity|binding|electron carrier activity	p.R31R(1)		autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	13					NADH(DB00157)	TTGCGGGCCCGAAAAGCCTGC	0.731000													3	11					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27089533	27089533	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:27089533G>C	ENST00000324856.7	+	8	2860	c.2489G>C	c.(2488-2490)gGa>gCa	p.G830A	ARID1A_ENST00000457599.2_Missense_Mutation_p.G830A|ARID1A_ENST00000374152.2_Missense_Mutation_p.G447A	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	830					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGCATGGCTGGAGGCATAAAC	0.582000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								11	33					0	0	1	0	0
UBQLN4	56893	broad.mit.edu	37	1	156020285	156020285	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:156020285C>G	ENST00000368309.3	-	4	630	c.538G>C	c.(538-540)Gag>Cag	p.E180Q	UBQLN4_ENST00000472638.1_Intron	NM_020131.3	NP_064516.2	Q9NRR5	UBQL4_HUMAN	ubiquilin 4	180						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)	16	Hepatocellular(266;0.133)|all_neural(408;0.195)					TGCTGCAGCTCCATGAAGTTG	0.592000													31	58					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61633172	61633172	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:61633172G>C	ENST00000398571.2	-	3	299	c.223C>G	c.(223-225)Caa>Gaa	p.Q75E		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	75					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			CGGAGCACTTGAACTTGGGCA	0.383000													25	77					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27101300	27101300	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:27101300C>T	ENST00000324856.7	+	18	4953	c.4582C>T	c.(4582-4584)Cga>Tga	p.R1528*	ARID1A_ENST00000540690.1_Intron|ARID1A_ENST00000457599.2_Intron|ARID1A_ENST00000374152.2_Nonsense_Mutation_p.R1145*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1528					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.R1528*(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGGCGTGAACCGAACAGATGA	0.602000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								20	60					0	0	1	0	0
PNPT1	87178	broad.mit.edu	37	2	55863489	55863489	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:55863489C>G	ENST00000447944.2	-	28	2321	c.2235G>C	c.(2233-2235)atG>atC	p.M745I		NM_033109.3	NP_149100.2	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	745	S1 motif.				mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GAGAAAGCCTCATTCTTCCAT	0.408000													12	29					0	0	1	0	0
RRM1	6240	broad.mit.edu	37	11	4123242	4123242	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:4123242C>T	ENST00000300738.5	+	2	243	c.39C>T	c.(37-39)gtC>gtT	p.V13V	RRM1_ENST00000423050.2_5'UTR	NM_001033.3	NP_001024.1	P23921	RIR1_HUMAN	ribonucleotide reductase M1	13	ATP-cone.|Allosteric activator binding (By similarity).				deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)	14		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	AAGAACGAGTCATGTTTGACA	0.318000													11	48					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57889539	57889539	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:57889539G>C	ENST00000381227.1	+	20	2972	c.2559G>C	c.(2557-2559)ttG>ttC	p.L853F	POLR2B_ENST00000441246.2_Missense_Mutation_p.L846F|POLR2B_ENST00000314595.5_Missense_Mutation_p.L853F|POLR2B_ENST00000431623.2_Missense_Mutation_p.L778F			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	853					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					ATGATGGTTTGATAGCTCCAG	0.428000													10	39					0	0	1	0	0
TTLL7	79739	broad.mit.edu	37	1	84417601	84417601	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:84417601C>T	ENST00000260505.8	-	3	461	c.84G>A	c.(82-84)atG>atA	p.M28I	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	28					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		CTTTCCTTTTCATTGTGCTTT	0.353000													25	50					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37602916	37602916	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr21:37602916G>C	ENST00000399151.3	+	14	1919	c.1834G>C	c.(1834-1836)Gaa>Caa	p.E612Q		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	612					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						AGTTTCTCTGGAAAGGGACGA	0.537000													14	69					0	0	1	0	0
CIB1	10519	broad.mit.edu	37	15	90774423	90774423	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:90774423C>G	ENST00000328649.6	-	5	530	c.369G>C	c.(367-369)ttG>ttC	p.L123F		NM_006384.3	NP_006375.2	Q99828	CIB1_HUMAN	calcium and integrin binding 1 (calmyrin)	123	EF-hand 1.				apoptosis|cell adhesion|double-strand break repair	apical plasma membrane|endoplasmic reticulum|filopodium|nucleoplasm	calcium ion binding|protein binding			lung(1)|prostate(1)	2	Melanoma(11;0.00551)|Lung NSC(78;0.0141)|all_lung(78;0.0303)		BRCA - Breast invasive adenocarcinoma(143;0.00269)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			CTTCTCTGTTCAAGGTTCCGT	0.562000													30	65					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81187357	81187357	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:81187357C>G	ENST00000394685.3	+	11	1532	c.1113C>G	c.(1111-1113)ctC>ctG	p.L371L	KIAA1199_ENST00000220244.3_Silent_p.L371L|KIAA1199_ENST00000356249.5_Silent_p.L371L			Q8WUJ3	K1199_HUMAN	KIAA1199	371										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GAGTTAACCTCAGCACCGAGG	0.473000													21	57					0	0	1	0	0
LILRA6	79168	broad.mit.edu	37	19	54744749	54744749	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:54744749C>G	ENST00000440558.2	-	5	961	c.913G>C	c.(913-915)Gag>Cag	p.E305Q	LILRB3_ENST00000407860.2_Intron|LILRA6_ENST00000245621.5_Missense_Mutation_p.E305Q|LILRA6_ENST00000270464.5_Intron|LILRA6_ENST00000396365.2_Missense_Mutation_p.E305Q|LILRA6_ENST00000391735.3_3'UTR|LILRA6_ENST00000419410.2_Missense_Mutation_p.E305Q					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCCGACCACTCGGAGGAGAGG	0.692000													13	106					0	0	1	0	0
SNRPB	6628	broad.mit.edu	37	20	2444494	2444494	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:2444494C>G	ENST00000339610.6	-	5	537	c.82G>C	c.(82-84)Ggc>Cgc	p.G28R	SNRPB_ENST00000381342.2_Missense_Mutation_p.G107R|SNRPB_ENST00000438552.2_Missense_Mutation_p.G107R			P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptides B and B1	107					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	10						GCAGCCCTGCCGATCCCTGGG	0.592000													19	69					0	0	1	0	0
FOXO3	2309	broad.mit.edu	37	6	108984779	108984779	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:108984779G>A	ENST00000406360.1	+	2	1086	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	FOXO3_ENST00000540898.1_Missense_Mutation_p.R28Q|FOXO3_ENST00000343882.6_Missense_Mutation_p.R248Q	NM_001455.3	NP_001446.1	O43524	FOXO3_HUMAN	forkhead box O3	248					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		AAAGCCCCCCGGCGGCGGGCT	0.587000													4	22					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18180504	18180504	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:18180504G>A	ENST00000600835.2	-	11	1339	c.1041C>T	c.(1039-1041)atC>atT	p.I347I	IL12RB1_ENST00000593993.2_Silent_p.I347I			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1		Fibronectin type-III 4.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						TTCCGACGCTGATATTCAGAG	0.597000													54	22					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14399102	14399102	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr5:14399102G>C	ENST00000344204.4	+	30	4561	c.4537G>C	c.(4537-4539)Gaa>Caa	p.E1513Q	TRIO_ENST00000509967.2_Missense_Mutation_p.E1464Q|TRIO_ENST00000537187.1_Missense_Mutation_p.E1513Q	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	1513	PH 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					CTTCCTTTTTGAAATGTCCTT	0.398000													53	81					0	0	1	0	0
CTU1	90353	broad.mit.edu	37	19	51607326	51607326	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:51607326G>A	ENST00000421832.2	-	2	545	c.501C>T	c.(499-501)atC>atT	p.I167I		NM_145232.3	NP_660275.2	Q7Z7A3	CTU1_HUMAN	cytosolic thiouridylase subunit 1	167					tRNA thio-modification|tRNA wobble uridine modification	cytosol	ATP binding|protein binding|transferase activity|tRNA binding			large_intestine(2)|lung(1)|urinary_tract(1)	4						CACCTGTCACGATGTGCGTGG	0.716000													10	2					0	0	1	0	0
CXorf23	256643	broad.mit.edu	37	X	19984595	19984595	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:19984595G>A	ENST00000379687.3	-	2	247	c.214C>T	c.(214-216)Cag>Tag	p.Q72*	CXorf23_ENST00000379682.4_Nonsense_Mutation_p.Q72*|CXorf23_ENST00000356980.3_Nonsense_Mutation_p.Q72*	NM_198279.3	NP_938020.2	A2AJT9	CX023_HUMAN	chromosome X open reading frame 23	72						mitochondrion				endometrium(2)|large_intestine(1)|lung(6)|skin(1)|urinary_tract(1)	11						TCATAAGACTGGTAATATATA	0.408000													45	103					0	0	1	0	0
SLC41A1	254428	broad.mit.edu	37	1	205764534	205764534	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:205764534C>G	ENST00000367137.3	-	9	2159	c.1145G>C	c.(1144-1146)gGa>gCa	p.G382A	SLC41A1_ENST00000468057.1_5'UTR	NM_173854.4	NP_776253.3	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 (magnesium transporter), member 1	382						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	17	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			AGAGTTCTCTCCGGGCATTCC	0.607000													11	32					0	0	1	0	0
DTX3L	151636	broad.mit.edu	37	3	122288058	122288058	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:122288058G>C	ENST00000296161.4	+	3	1311	c.1122G>C	c.(1120-1122)atG>atC	p.M374I	DTX3L_ENST00000383661.3_Intron	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	374					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		CCAATTACATGATGAATGTAA	0.368000													38	68					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207679266	207679266	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:207679266G>C	ENST00000367049.4	+	2	139	c.139G>C	c.(139-141)Gaa>Caa	p.E47Q	CR1_ENST00000367051.1_Missense_Mutation_p.E47Q|CR1_ENST00000400960.2_Missense_Mutation_p.E47Q|CR1_ENST00000367053.1_Missense_Mutation_p.E47Q|CR1_ENST00000367050.4_3'UTR|CR1_ENST00000367052.1_Missense_Mutation_p.E47Q	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	47	Sushi 1.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CAATGCCCCAGAATGGCTTCC	0.428000													12	112					0	0	1	0	0
ZNF653	115950	broad.mit.edu	37	19	11594542	11594542	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:11594542G>A	ENST00000293771.5	-	9	1939	c.1803C>T	c.(1801-1803)gtC>gtT	p.V601V	CTC-398G3.6_ENST00000585656.1_Intron	NM_138783.3	NP_620138.2	Q96CK0	ZN653_HUMAN	zinc finger protein 653	601					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	17						TGTGGAACTTGACGCTGTCCA	0.607000													11	11					0	0	1	0	0
MUC21	394263	broad.mit.edu	37	6	30954637	30954637	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:30954637G>A	ENST00000376296.3	+	2	926	c.685G>A	c.(685-687)Gag>Aag	p.E229K	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	229	28 X 15 AA approximate tandem repeats.|Ser-rich.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						CACCAACTCTGAGTCCAGCAC	0.627000													67	181					0	0	1	0	0
C9orf72	203228	broad.mit.edu	37	9	27548392	27548392	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr9:27548392G>C	ENST00000380003.3	-	11	1351	c.1288C>G	c.(1288-1290)Ctt>Gtt	p.L430V	C9orf72_ENST00000488117.1_5'UTR	NM_001256054.1|NM_018325.3	NP_001242983.1|NP_060795.1	Q96LT7	CI072_HUMAN	chromosome 9 open reading frame 72	430										breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|pancreas(1)	23		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		AGGTTCCGAAGAGATTTAAAG	0.318000													63	22					0	0	1	0	0
RASSF3	283349	broad.mit.edu	37	12	65085318	65085318	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr12:65085318G>T	ENST00000542104.1	+	4	646	c.526G>T	c.(526-528)Gac>Tac	p.D176Y	RASSF3_ENST00000336061.2_Missense_Mutation_p.D176Y	NM_178169.3	NP_835463.1	Q86WH2	RASF3_HUMAN	Ras association (RalGDS/AF-6) domain family member 3	176	Ras-associating.				signal transduction	cytoplasm|microtubule	identical protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10			Lung(2;0.00133)|LUAD - Lung adenocarcinoma(6;0.0665)|LUSC - Lung squamous cell carcinoma(43;0.132)	GBM - Glioblastoma multiforme(28;0.0611)		GCCCAGAACAGACACACTTAG	0.443000													14	51					1.5739e-10	1.6441e-10	1	1	0
MAPKAPK3	7867	broad.mit.edu	37	3	50685381	50685381	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:50685381C>G	ENST00000446044.1	+	13	1649	c.1053C>G	c.(1051-1053)atC>atG	p.I351M	MAPKAPK3_ENST00000357955.2_Missense_Mutation_p.I351M	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	351					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity	p.I351I(1)		central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		AGGTGAAGATCAAGGACCTGA	0.552000													19	45					0	0	1	0	0
UPF1	5976	broad.mit.edu	37	19	18963051	18963051	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:18963051C>T	ENST00000262803.5	+	6	1190	c.918C>T	c.(916-918)ttC>ttT	p.F306F	UPF1_ENST00000599848.1_Silent_p.F306F|UPF1_ENST00000600310.1_3'UTR	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	306	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						AGAACATATTCGGGCCCCTGG	0.632000													50	26					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76532578	76532578	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:76532578C>G	ENST00000307431.8	+	16	2734	c.2349C>G	c.(2347-2349)ctC>ctG	p.L783L	CNTNAP4_ENST00000476707.1_Silent_p.L787L|CNTNAP4_ENST00000377504.4_Silent_p.L735L|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000478060.1_Silent_p.L711L	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	784	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GGCCTCTGCTCTGCCAGGGAG	0.413000													9	46					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11272295	11272295	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:11272295G>C	ENST00000409790.1	+	24	3140	c.2910G>C	c.(2908-2910)agG>agC	p.R970S	CLEC16A_ENST00000381822.2_Missense_Mutation_p.R57S	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	970								p.0?(1)		breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						ACGTGGCCAGGAGCGCAGCCG	0.627000													29	86					0	0	1	0	0
AQR	9716	broad.mit.edu	37	15	35155072	35155072	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr15:35155072C>G	ENST00000156471.5	-	33	4250	c.4025G>C	c.(4024-4026)aGa>aCa	p.R1342T		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	1342						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TCCTACCTTTCTAGTAGTTGG	0.388000													26	31					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34087923	34087923	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:34087923G>C	ENST00000397527.1	+	28	4543	c.3823G>C	c.(3823-3825)Gat>Cat	p.D1275H	CEP250_ENST00000342580.4_Missense_Mutation_p.D1219H	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1275	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GCGTCTAACTGATACTGAGGC	0.512000													36	97					0	0	1	0	0
GPR50-AS1	100128688	broad.mit.edu	37	X	150345081	150345081	+	RNA	SNP	G	G	C			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:150345081G>C	ENST00000454196.1	-	0	541																											CTGACTCTCAGAGAGGGAGGC	0.582000													7	22					0	0	1	0	0
SMG5	23381	broad.mit.edu	37	1	156237957	156237957	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:156237957C>G	ENST00000361813.5	-	9	1001	c.857G>C	c.(856-858)aGg>aCg	p.R286T	SMG5_ENST00000368267.5_Missense_Mutation_p.R286T	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	286					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					CACTAGCAACCTTTTAATGTC	0.468000													80	116					0	0	1	0	0
MSH5-SAPCD1	100532732	broad.mit.edu	37	6	31711711	31711711	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:31711711C>T	ENST00000493662.2	+	6	502	c.446C>T	c.(445-447)tCt>tTt	p.S149F	MSH5_ENST00000375740.3_Missense_Mutation_p.S149F|MSH5_ENST00000375750.3_Missense_Mutation_p.S149F|MSH5_ENST00000375742.3_Missense_Mutation_p.S149F|MSH5_ENST00000375755.3_Missense_Mutation_p.S149F|MSH5_ENST00000375703.3_Missense_Mutation_p.S149F|MSH5_ENST00000534153.4_Missense_Mutation_p.S149F|MSH5_ENST00000482280.1_3'UTR																							CGCCTCCTTTCTGGAAACTAC	0.458000													94	193					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72827194	72827194	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr16:72827194G>A	ENST00000268489.5	-	9	10059	c.9387C>T	c.(9385-9387)ctC>ctT	p.L3129L	ZFHX3_ENST00000397992.5_Silent_p.L2215L	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3129					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				AGGGGCTGTTGAGGCCCGGGA	0.547000													96	52					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167250742	167250742	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:167250742G>A	ENST00000308378.3	-	8	1227	c.922C>T	c.(922-924)Cta>Tta	p.L308L	WDR49_ENST00000476376.1_Silent_p.L133L|WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Silent_p.L372L	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	308										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						TTGTTCCATAGAACAATTTCT	0.373000													18	27					0	0	1	0	0
FASTKD5	60493	broad.mit.edu	37	20	3129477	3129477	+	Silent	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:3129477G>A	ENST00000380266.3	-	2	561	c.240C>T	c.(238-240)ttC>ttT	p.F80F	UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000217173.2_Intron|UBOX5_ENST00000348031.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	80					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						AAGTCTTGCTGAATTCCAAAC	0.478000													13	39					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71209105	71209105	+	Silent	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:71209105C>T	ENST00000554752.2	-	6	1529	c.1530G>A	c.(1528-1530)ctG>ctA	p.L510L	MAP3K9_ENST00000554146.1_Silent_p.L247L|MAP3K9_ENST00000555993.2_Silent_p.L510L|MAP3K9_ENST00000381250.4_Silent_p.L510L|MAP3K9_ENST00000553414.1_Silent_p.L204L	NM_001284230.1	NP_001271159.1	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	510					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CCTTGAGCTTCAGCCGGCTCT	0.592000													21	52					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156638326	156638326	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:156638326G>A	ENST00000296518.7	+	8	1797	c.1588G>A	c.(1588-1590)Gat>Aat	p.D530N	GUCY1A3_ENST00000513574.1_Missense_Mutation_p.D530N|GUCY1A3_ENST00000393832.3_Missense_Mutation_p.D272N|GUCY1A3_ENST00000511108.1_Missense_Mutation_p.D530N|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.D530N|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.D530N|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.D530N			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	530	Guanylate cyclase.			GDAYCVA -> AMPIVWL (in Ref. 1; CAA47145).	blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		GACCATTGGCGATGCCTATTG	0.408000													15	55					0	0	1	0	0
CEP85	64793	broad.mit.edu	37	1	26570761	26570761	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:26570761G>A	ENST00000252992.4	+	3	291	c.160G>A	c.(160-162)Gac>Aac	p.D54N	CEP85_ENST00000451429.2_Intron	NM_001281517.1|NM_022778.2	NP_001268446.1|NP_073615.2	Q6P2H3	CEP85_HUMAN	centrosomal protein 85kDa	54						centrosome|nucleolus|spindle pole				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(11)|skin(2)	25						AAGTGTAGCCGACAGTGGGGA	0.483000													8	32					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46263969	46263969	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr4:46263969C>T	ENST00000510861.1	-	9	1206	c.1033G>A	c.(1033-1035)Gat>Aat	p.D345N	GABRA2_ENST00000514090.1_Missense_Mutation_p.D345N|GABRA2_ENST00000356504.1_Missense_Mutation_p.D345N|GABRA2_ENST00000381620.4_Missense_Mutation_p.D345N|GABRA2_ENST00000507069.1_Missense_Mutation_p.D345N|GABRA2_ENST00000515082.1_Missense_Mutation_p.D345N|GABRA2_ENST00000540012.1_Missense_Mutation_p.D290N			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	345					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTCTTCCCATCCCAAGCCCAT	0.378000													10	36					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149489793	149489793	+	RNA	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:149489793G>A	ENST00000378016.2	+	0	5849							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGCCAGTGCCGTGGCATCCAC	0.692000													8	17					0	0	1	0	0
ZNF81	347344	broad.mit.edu	37	X	47774577	47774577	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chrX:47774577C>T	ENST00000376954.1	+	6	900	c.532C>T	c.(532-534)Cca>Tca	p.P178S	ZNF81_ENST00000338637.7_Missense_Mutation_p.P178S			P51508	ZNF81_HUMAN	zinc finger protein 81	178						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(1)|lung(1)|skin(1)	4		all_lung(315;0.0973)				ATTTGTTCATCCAAGCCCAAA	0.313000													15	35					0	0	1	0	0
GNB1	2782	broad.mit.edu	37	1	1737960	1737960	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:1737960G>A	ENST00000378609.4	-	6	552	c.221C>T	c.(220-222)tCg>tTg	p.S74L		NM_001282539.1|NM_002074.3	NP_001269468.1|NP_002065.1	P62873	GBB1_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 1	74					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	12	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		ACCATCCTGCGAGGCACTGAC	0.483000													4	18					0	0	1	0	0
ZC3H13	23091	broad.mit.edu	37	13	46594629	46594629	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:46594629G>A	ENST00000242848.4	-	5	751	c.403C>T	c.(403-405)Cca>Tca	p.P135S	ZC3H13_ENST00000282007.3_Missense_Mutation_p.P135S			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	135							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCACTTTCTGGAGTTCTTTCC	0.313000													5	35					0	0	1	0	0
RALY	22913	broad.mit.edu	37	20	32664968	32664968	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:32664968G>A	ENST00000375114.3	+	7	1323	c.745G>A	c.(745-747)Gag>Aag	p.E249K	RALY_ENST00000246194.3_Missense_Mutation_p.E265K	NM_007367.3	NP_031393.2	Q9UKM9	RALY_HUMAN	RALY heterogeneous nuclear ribonucleoprotein	265	Epitope (recognized by BKRF1 antibodies).|Poly-Gly.					catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|RNA binding			kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12						CACAACTTCTGAGGCAGGCCT	0.711000													8	48					0	0	1	0	0
AIP	9049	broad.mit.edu	37	11	67250653	67250653	+	Silent	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr11:67250653C>G	ENST00000279146.3	+	1	142	c.24C>G	c.(22-24)ctC>ctG	p.L8L		NM_003977.2	NP_003968.2	O00170	AIP_HUMAN	aryl hydrocarbon receptor interacting protein	8					protein maturation by protein folding|protein targeting to mitochondrion	nucleus	signal transducer activity|transcription coactivator activity|transcription factor binding|unfolded protein binding			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(2)	7						TCGCAAGACTCCGGGAGGACG	0.582000									Familial Isolated Pituitary Adenoma				10	32					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37353605	37353605	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr20:37353605G>A	ENST00000217420.1	+	1	501	c.238G>A	c.(238-240)Gag>Aag	p.E80K		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	80					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	AGCGCCCGTCGAGGGAGACAT	0.662000													8	25					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101212742	101212742	+	Nonsense_Mutation	SNP	G	G	C	rs138298776		TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr3:101212742G>C	ENST00000394095.2	-	3	214	c.161C>G	c.(160-162)tCa>tGa	p.S54*	SENP7_ENST00000394094.2_Nonsense_Mutation_p.S54*|SENP7_ENST00000358203.3_Nonsense_Mutation_p.S21*|SENP7_ENST00000348610.3_Nonsense_Mutation_p.S21*|SENP7_ENST00000314261.7_Nonsense_Mutation_p.S54*|SENP7_ENST00000394091.1_Nonsense_Mutation_p.S21*	NM_001282802.1|NM_020654.3	NP_001269731.1|NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	54					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CCAGCGTTCTGAGCTTCTGAA	0.299000													27	60					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215813322	215813322	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:215813322C>G	ENST00000272895.7	-	47	7321	c.7102G>C	c.(7102-7104)Gaa>Caa	p.E2368Q	ABCA12_ENST00000389661.4_Missense_Mutation_p.E2050Q|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2368	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GTACTCACTTCTTTAATATCC	0.433000													8	24					0	0	1	0	0
BABAM1	29086	broad.mit.edu	37	19	17379718	17379718	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr19:17379718G>A	ENST00000359435.4	+	2	296	c.103G>A	c.(103-105)Gag>Aag	p.E35K	BABAM1_ENST00000601043.1_Missense_Mutation_p.E35K|BABAM1_ENST00000448635.2_3'UTR|BABAM1_ENST00000447614.2_Missense_Mutation_p.E35K|BABAM1_ENST00000598188.1_Missense_Mutation_p.E35K|CTD-2278I10.6_ENST00000596542.1_5'UTR|BABAM1_ENST00000595632.1_Missense_Mutation_p.E35K	NM_001033549.1	NP_001028721.1	Q9NWV8	BABA1_HUMAN	BRISC and BRCA1 A complex member 1	35					chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|protein K63-linked deubiquitination|response to ionizing radiation	BRCA1-A complex|BRISC complex|cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5						TGAAGGGGCTGAGGACCGGGC	0.672000													6	1					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11562905	11562905	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr1:11562905delC	ENST00000294484.6	+	3	1405	c.1267delC	c.(1267-1269)cagfs	p.Q423fs	PTCHD2_ENST00000389575.3_Frame_Shift_Del_p.Q423fs	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	423					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GGCTAAGTTTCAGAGCTTCGT	0.542													10	49	---	---	---	---					
PNKD	25953	broad.mit.edu	37	2	219209216	219209218	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr2:219209216_219209218delGTG	ENST00000273077.4	+	9	958_960	c.907_909delGTG	c.(907-909)gtgdel	p.V304del	AC021016.8_ENST00000411433.1_RNA|PNKD_ENST00000258362.3_In_Frame_Del_p.V280del|PNKD_ENST00000436005.2_In_Frame_Del_p.V244del	NM_015488.4	NP_056303.3	Q8N490	PNKD_HUMAN	paroxysmal nonkinesigenic dyskinesia	304						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	10		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTTTGCAGGTGTGGTGGAGCCCG	0.616													2	4	---	---	---	---					
ZNRD1-AS1	80862	broad.mit.edu	37	6	29975230	29975243	+	RNA	DEL	CGGATACCGCGGCT	CGGATACCGCGGCT	-			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr6:29975230_29975243delCGGATACCGCGGCT	ENST00000376797.3	-	0	1172				ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA																							TGGACCGCCGCGGATACCGCGGCTCAGATTACCC	0.640													9	32	---	---	---	---					
ATP6V0E2	155066	broad.mit.edu	37	7	149576569	149576570	+	In_Frame_Ins	INS	-	-	AGTCTTCCC			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr7:149576569_149576570insAGTCTTCCC	ENST00000421974.2	+	3	1396_1397	c.445_446insAGTCTTCCC	c.(445-447)aag>aAGTCTTCCCag	p.155_156insSSQ	ATP6V0E2_ENST00000606024.1_In_Frame_Ins_p.106_107insSSQ|ATP6V0E2_ENST00000479613.1_In_Frame_Ins_p.129_130insSSQ|ATP6V0E2_ENST00000456496.2_3'UTR|ATP6V0E2_ENST00000425642.2_3'UTR|ATP6V0E2-AS1_ENST00000464939.1_RNA|ATP6V0E2_ENST00000495408.1_3'UTR	NM_001100592.1	NP_001094062.1	Q8NHE4	VA0E2_HUMAN	ATPase, H+ transporting V0 subunit e2	0					ATP hydrolysis coupled proton transport|cell growth|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|vacuolar acidification	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuole	ATPase activity, coupled to transmembrane movement of ions|hydrogen ion transmembrane transporter activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00256)			TGGTTCCTGGAAGTCTTCCCAG	0.673													3	5	---	---	---	---					
TPTE2P1	646405	broad.mit.edu	37	13	25527490	25527491	+	RNA	INS	-	-	AAAAAG			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr13:25527490_25527491insAAAAAG	ENST00000429698.1	-	0	282																											AGGAAGGTTCTAAAAAAAATTT	0.252													3	3	---	---	---	---					
SNHG24	101929369	broad.mit.edu	37	14	101438564	101438564	+	RNA	DEL	A	A	-			TCGA-ZF-A9R7-01A-11D-A38G-08	TCGA-ZF-A9R7-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c28dc94-0858-4791-858d-ae3ee12b4969	f8237edf-efc1-4fe6-a91e-b0e1c78f2a5a	g.chr14:101438564delA	ENST00000554693.2	+	0	299																											TATCTAGTTTAAAAAAAATCA	0.398													7	14	---	---	---	---					
