Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SMARCC2	6601	broad.mit.edu	37	12	56565666	56565666	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:56565666C>T	ENST00000394023.3	-	21	2087	c.1982G>A	c.(1981-1983)cGc>cAc	p.R661H	SMARCC2_ENST00000550164.1_Missense_Mutation_p.R661H|RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000347471.4_Missense_Mutation_p.R661H|SMARCC2_ENST00000267064.4_Missense_Mutation_p.R630H	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	630					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity	p.R630H(2)		breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GTCCTGTGTGCGGCTTCCCAC	0.532000													3	57					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100344863	100344863	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:100344863G>A	ENST00000262233.6	+	4	564	c.425G>A	c.(424-426)gGg>gAg	p.G142E	EML1_ENST00000327921.9_Missense_Mutation_p.G130E|EML1_ENST00000556758.1_3'UTR|EML1_ENST00000334192.4_Missense_Mutation_p.G161E	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	142						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GTGTCTCCTGGGGGTCGAAGG	0.478000													11	46					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45455843	45455843	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr15:45455843C>T	ENST00000321429.4	+	33	4769	c.4362C>T	c.(4360-4362)atC>atT	p.I1454I	CTD-2651B20.1_ENST00000558039.1_lincRNA|DUOX1_ENST00000389037.3_Silent_p.I1454I|DUOX1_ENST00000561166.1_Silent_p.I1100I	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	1454					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		ACATCTACATCACCCAGCTGG	0.587000											OREG0023103	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	31					0	0	1	0	0
TUBE1	51175	broad.mit.edu	37	6	112394097	112394097	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:112394097C>G	ENST00000368662.5	-	10	1036	c.958G>C	c.(958-960)Gat>Cat	p.D320H	TUBE1_ENST00000604814.1_5'UTR	NM_016262.4	NP_057346.1	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	320					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	12		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		AACATCTGATCCAATCTGCAA	0.368000													13	52					0	0	1	0	0
PDF	64146	broad.mit.edu	37	16	69362930	69362930	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:69362930C>T	ENST00000288022.1	-	2	751	c.727G>A	c.(727-729)Gac>Aac	p.D243N	RP11-343C2.12_ENST00000562949.1_3'UTR|COG8_ENST00000306875.4_3'UTR	NM_022341.1	NP_071736.1	Q9HBH1	DEFM_HUMAN	peptide deformylase (mitochondrial)	243					N-terminal protein amino acid modification|peptidyl-methionine modification|positive regulation of cell proliferation|translation	mitochondrion	iron ion binding|peptide deformylase activity			NS(1)|prostate(1)	2						AAGCTTTAGTCATTCACCTTC	0.488000													23	112					0	0	1	0	0
BCOR	54880	broad.mit.edu	37	X	39922007	39922007	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:39922007C>T	ENST00000342274.4	-	9	4425	c.4063G>A	c.(4063-4065)Gat>Aat	p.D1355N	BCOR_ENST00000378444.4_Missense_Mutation_p.D1389N|BCOR_ENST00000378455.4_Missense_Mutation_p.D1337N|BCOR_ENST00000397354.3_Missense_Mutation_p.D1355N|BCOR_ENST00000378463.1_Missense_Mutation_p.D232N	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	1389					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						ACCTTGCCATCGGCATTCTCC	0.577000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						9	22					0	0	1	0	0
ZNF793	390927	broad.mit.edu	37	19	38028237	38028237	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:38028237C>G	ENST00000445217.1	+	4	712	c.677C>G	c.(676-678)cCc>cGc	p.P226R	ZNF793_ENST00000542455.1_Missense_Mutation_p.P226R|ZNF793_ENST00000588578.1_3'UTR|ZNF793_ENST00000587143.1_Missense_Mutation_p.P226R|ZNF793_ENST00000589319.1_Intron			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACAGAAAAACCCCACGTCTGT	0.473000													3	12					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108156459	108156459	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:108156459G>A	ENST00000273353.3	-	26	3279	c.3223C>T	c.(3223-3225)Cgg>Tgg	p.R1075W		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1075						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						ATACTTTCCCGATTCAGCTTT	0.488000													14	118					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101786074	101786074	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:101786074C>T	ENST00000263468.8	+	1	329	c.59C>T	c.(58-60)tCg>tTg	p.S20L	ANGPTL5_ENST00000334289.3_Intron	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	20							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		ACTGAATCATCGGACAACCTC	0.677000													30	67					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112151535	112151535	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:112151535G>A	ENST00000412145.1	-	17	4391	c.1838C>T	c.(1837-1839)aCg>aTg	p.T613M	PTPN3_ENST00000262539.3_Missense_Mutation_p.T590M|PTPN3_ENST00000446349.1_Missense_Mutation_p.T568M|PTPN3_ENST00000394827.3_Missense_Mutation_p.T212M|PTPN3_ENST00000497739.1_5'UTR|PTPN3_ENST00000374541.2_Missense_Mutation_p.T744M	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	744					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						TGTGAGAGTCGTCAACATGAC	0.498000													22	24					0	0	1	0	0
LEMD3	23592	broad.mit.edu	37	12	65632588	65632588	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:65632588T>C	ENST00000308330.2	+	6	1941	c.1915T>C	c.(1915-1917)Tgc>Cgc	p.C639R		NM_001167614.1|NM_014319.4	NP_001161086.1|NP_055134.2	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	639	Poly-Leu.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	36			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		ATTGTTGTTATGCTTAGGTAA	0.348000													9	51					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92076984	92076984	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:92076984G>C	ENST00000256343.3	-	21	2594	c.2438C>G	c.(2437-2439)tCt>tGt	p.S813C		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	813					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				GCACTCAGTAGAGGCTGACCA	0.378000													11	40					0	0	1	0	0
AASDHPPT	60496	broad.mit.edu	37	11	105950307	105950307	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:105950307G>A	ENST00000278618.4	+	2	519	c.297G>A	c.(295-297)tcG>tcA	p.S99S		NM_015423.2	NP_056238.2	Q9NRN7	ADPPT_HUMAN	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	99					macromolecule biosynthetic process|pantothenate metabolic process	cytosol	holo-[acyl-carrier-protein] synthase activity|magnesium ion binding|protein binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)	17		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.78e-05)|Epithelial(105;0.00622)|all cancers(92;0.041)		AGGACTCATCGAATCCTTACC	0.383000													13	38					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113346449	113346449	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:113346449G>A	ENST00000452357.2	+	2	479	c.289G>A	c.(289-291)Gag>Aag	p.E97K	RP1-71H24.1_ENST00000552784.1_RNA|OAS1_ENST00000553185.1_Missense_Mutation_p.E97K|OAS1_ENST00000445409.2_Missense_Mutation_p.E97K|OAS1_ENST00000551241.1_Missense_Mutation_p.E97K|OAS1_ENST00000202917.5_Missense_Mutation_p.E97K	NM_002534.2	NP_002525.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	97					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						TCGCCGGGGAGAGTTCATCCA	0.557000													4	27					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688281	60688281	+	Missense_Mutation	SNP	G	G	A	rs139460584		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:60688281G>A	ENST00000335712.6	-	4	1993	c.1766C>T	c.(1765-1767)tCg>tTg	p.S589L	BCL11A_ENST00000358510.4_Missense_Mutation_p.S555L|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000538214.1_Missense_Mutation_p.S555L|BCL11A_ENST00000356842.4_Missense_Mutation_p.S589L|BCL11A_ENST00000537768.1_Missense_Mutation_p.S258L|BCL11A_ENST00000477659.1_5'UTR	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	589					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GCCGGCCACCGAGTCTTCGTC	0.677000			T	IGH@	B-CLL								12	19					0	0	1	0	0
PCGF2	7703	broad.mit.edu	37	17	36894838	36894838	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:36894838C>G	ENST00000580830.1	-	9	1137	c.436G>C	c.(436-438)Gag>Cag	p.E146Q	PCGF2_ENST00000581345.1_Missense_Mutation_p.E146Q|PCGF2_ENST00000578109.1_Missense_Mutation_p.R93P|PCGF2_ENST00000360797.2_Missense_Mutation_p.E146Q|PCGF2_ENST00000579882.1_Missense_Mutation_p.R147P|PCGF2_ENST00000585100.1_Missense_Mutation_p.R147P			P35227	PCGF2_HUMAN	polycomb group ring finger 2	146					negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	10	Breast(7;9.07e-22)					CCCTTCTTCTCGTCCCGGTCC	0.602000													4	45					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117718260	117718260	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:117718260C>G	ENST00000368508.3	-	7	795	c.597G>C	c.(595-597)ttG>ttC	p.L199F	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.L208F	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	199	Fibronectin type-III 2.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TATTCCTAATCAAAGGTGCAG	0.403000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								7	59					0	0	1	0	0
FSTL3	10272	broad.mit.edu	37	19	677931	677931	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:677931C>T	ENST00000166139.4	+	2	275	c.243C>T	c.(241-243)atC>atT	p.I81I		NM_005860.2	NP_005851.1	O95633	FSTL3_HUMAN	follistatin-like 3 (secreted glycoprotein)	81	TB.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoclast differentiation|ossification|positive regulation of cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	extracellular space|nucleus	activin binding|fibronectin binding						all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAACAAGATCAACCTCCTCG	0.622000			T	CCND1	B-CLL								16	38					0	0	1	0	0
TSR1	55720	broad.mit.edu	37	17	2234307	2234307	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:2234307C>T	ENST00000301364.5	-	9	2672	c.1593G>A	c.(1591-1593)caG>caA	p.Q531Q		NM_018128.4	NP_060598.3	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)						ribosome assembly	nucleolus	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	20						TAGTAAAGTTCTGAAACTGAA	0.393000													8	43					0	0	1	0	0
HSPB2	3316	broad.mit.edu	37	11	111784274	111784274	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:111784274G>A	ENST00000304298.3	+	2	792	c.204G>A	c.(202-204)agG>agA	p.R68R	HSPB2_ENST00000537382.1_Silent_p.R68R|CRYAB_ENST00000527950.1_Intron|CRYAB_ENST00000533475.1_Intron|HSPB2-C11orf52_ENST00000534100.1_Intron	NM_001541.3	NP_001532.1	Q16082	HSPB2_HUMAN	heat shock 27kDa protein 2	68					response to heat|response to unfolded protein	cytosol|nucleus	enzyme activator activity|protein binding			large_intestine(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(61;3.75e-11)|all_epithelial(67;2.33e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		CCGAGCTTAGGCTCAGTGAGG	0.617000													6	64					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170786725	170786725	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:170786725C>T	ENST00000436636.2	-	30	3955	c.3611G>A	c.(3610-3612)aGa>aAa	p.R1204K	TNIK_ENST00000470834.1_Missense_Mutation_p.R1167K|TNIK_ENST00000460047.1_Missense_Mutation_p.R1141K|TNIK_ENST00000488470.1_Missense_Mutation_p.R1149K|TNIK_ENST00000341852.6_Missense_Mutation_p.R1120K|TNIK_ENST00000475336.1_Missense_Mutation_p.R1112K|TNIK_ENST00000369326.5_Missense_Mutation_p.R1182K|TNIK_ENST00000357327.5_Missense_Mutation_p.R1175K|TNIK_ENST00000538048.1_Missense_Mutation_p.R1156K|TNIK_ENST00000284483.8_Missense_Mutation_p.R1196K	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	1204	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			AACCTTTAATCTTTGACCTTC	0.383000													11	57					0	0	1	0	0
RPTOR	57521	broad.mit.edu	37	17	78519460	78519460	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:78519460C>A	ENST00000306801.3	+	1	393	c.31C>A	c.(31-33)Ctg>Atg	p.L11M	RPTOR_ENST00000570891.1_Missense_Mutation_p.L11M|RPTOR_ENST00000544334.2_Missense_Mutation_p.L11M|RPTOR_ENST00000537330.1_5'UTR	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	11					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						ATCGCCTCTTCTGGGCCTGGG	0.527000													7	31					8.12818e-05	8.37449e-05	1	1	0
FOXO3	2309	broad.mit.edu	37	6	108985342	108985342	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:108985342G>A	ENST00000406360.1	+	2	1649	c.1306G>A	c.(1306-1308)Gga>Aga	p.G436R	FOXO3_ENST00000343882.6_Missense_Mutation_p.G436R|FOXO3_ENST00000540898.1_Missense_Mutation_p.G216R	NM_001455.3	NP_001446.1	O43524	FOXO3_HUMAN	forkhead box O3	436					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		CACGGTGTTCGGACCTTCATC	0.572000													5	47					0	0	1	0	0
PAH	5053	broad.mit.edu	37	12	103306626	103306626	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:103306626C>T	ENST00000553106.1	-	2	583	c.111G>A	c.(109-111)ctG>ctA	p.L37L	PAH_ENST00000307000.2_Silent_p.L32L|PAH_ENST00000551988.1_5'UTR	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	37	ACT.				catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	GTGAGAAGATCAGTGATATGG	0.368000													21	72					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165971968	165971968	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:165971968C>T	ENST00000360093.3	-	19	4002	c.3511G>A	c.(3511-3513)Gaa>Aaa	p.E1171K	SCN3A_ENST00000409101.3_Missense_Mutation_p.E1122K|SCN3A_ENST00000283254.7_Missense_Mutation_p.E1171K	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1171						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TGTTTACCTTCAGTAAAACAA	0.393000													8	63					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136700395	136700395	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:136700395G>A	ENST00000445907.2	+	3	1311	c.783G>A	c.(781-783)caG>caA	p.Q261Q	CHRM2_ENST00000402486.3_Silent_p.Q261Q|CHRM2_ENST00000320658.5_Silent_p.Q261Q|hsa-mir-490_ENST00000439694.1_RNA|hsa-mir-490_ENST00000593789.1_RNA|hsa-mir-490_ENST00000598184.1_RNA|hsa-mir-490_ENST00000586239.1_RNA|hsa-mir-490_ENST00000425981.2_RNA|hsa-mir-490_ENST00000597642.1_RNA|CHRM2_ENST00000453373.1_Silent_p.Q261Q|CHRM2_ENST00000401861.1_Silent_p.Q261Q|hsa-mir-490_ENST00000592183.1_RNA|CHRM2_ENST00000397608.3_Silent_p.Q261Q	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	261					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ACAAAATCCAGAATGGCAAAG	0.507000													8	19					0	0	1	0	0
PRRT1	80863	broad.mit.edu	37	6	32117452	32117452	+	Silent	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:32117452G>C	ENST00000211413.5	-	3	730	c.606C>G	c.(604-606)ctC>ctG	p.L202L	PRRT1_ENST00000375152.2_Silent_p.L121L|PRRT1_ENST00000375150.2_Silent_p.L121L|PRRT1_ENST00000467780.1_5'UTR	NM_030651.3	NP_085154.3	Q99946	PRRT1_HUMAN	proline-rich transmembrane protein 1	202					response to biotic stimulus	integral to membrane				breast(2)|endometrium(1)|kidney(1)|lung(2)	6						GCGGCGGGGGGAGAGTGGAGG	0.672000													4	11					0	0	1	0	0
ZNF773	374928	broad.mit.edu	37	19	58016740	58016740	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:58016740G>T	ENST00000599847.1	+	3	376	c.234G>T	c.(232-234)tgG>tgT	p.W78C	ZNF773_ENST00000282292.4_Missense_Mutation_p.W78C|ZNF773_ENST00000593916.1_Missense_Mutation_p.W77C|ZNF773_ENST00000598770.1_Missense_Mutation_p.W77C			Q6PK81	ZN773_HUMAN	zinc finger protein 773	78	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		TGCCTGCTTGGGAAGTTGTGA	0.517000													6	40					8.12818e-05	8.37449e-05	1	1	0
HERC1	8925	broad.mit.edu	37	15	64050523	64050523	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr15:64050523C>T	ENST00000443617.2	-	4	1159	c.1072G>A	c.(1072-1074)Gat>Aat	p.D358N		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	358					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TGAATGCTATCTGGGCTAGCA	0.418000													3	15					0	0	1	0	0
SF3B3	23450	broad.mit.edu	37	16	70562829	70562829	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:70562829C>T	ENST00000302516.5	+	3	335	c.124C>T	c.(124-126)Cgc>Tgc	p.R42C		NM_012426.4	NP_036558.3	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3, 130kDa	42					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(2)|endometrium(8)|kidney(2)|large_intestine(8)|liver(3)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	53		Ovarian(137;0.0694)				GGAGCTGCTTCGCCCAGACCC	0.473000													8	41					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62293819	62293819	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:62293819C>T	ENST00000378024.4	-	5	8344	c.8070G>A	c.(8068-8070)ttG>ttA	p.L2690L	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2690					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TAGGCCCTTTCAACTTTCCCT	0.473000													45	134					0	0	1	0	0
SOWAHB	345079	broad.mit.edu	37	4	77818017	77818017	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr4:77818017G>A	ENST00000334306.2	-	1	985	c.986C>T	c.(985-987)tCg>tTg	p.S329L		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	329																	TGGCAGCACCGACCAGGCGCG	0.647000													3	22					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236734738	236734738	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:236734738C>G	ENST00000366582.3	-	28	3975	c.3861G>C	c.(3859-3861)ttG>ttC	p.L1287F	HEATR1_ENST00000366581.2_Missense_Mutation_p.L1206F	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1287					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ACTGAACTATCAACTCCACGT	0.438000													13	37					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67692454	67692454	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr15:67692454G>A	ENST00000335894.4	+	14	1974	c.1908G>A	c.(1906-1908)atG>atA	p.M636I	IQCH_ENST00000358767.3_Missense_Mutation_p.M372I|IQCH_ENST00000546225.1_Missense_Mutation_p.M293I|IQCH_ENST00000360277.4_Missense_Mutation_p.M297I	NM_001031715.2	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H	636										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		CCTCACAGATGATAGAGCAGC	0.418000													6	29					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154176073	154176073	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:154176073G>A	ENST00000360256.4	-	13	2213	c.2013C>T	c.(2011-2013)ttC>ttT	p.F671F		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	671	F5/8 type A 2.|Plastocyanin-like 4.		Missing (in HEMA; severe).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	ATCCAGAGAAGAAGACAGAAA	0.418000													16	68					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73485668	73485668	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:73485668C>T	ENST00000314256.7	+	9	1273	c.879C>T	c.(877-879)ctC>ctT	p.L293L	KIAA0195_ENST00000579208.1_Intron|KIAA0195_ENST00000583795.1_Intron|KIAA0195_ENST00000375248.5_Silent_p.L303L	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	293					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCGGCTTCCTCATCACCAATG	0.627000													4	28					0	0	1	0	0
XPO6	23214	broad.mit.edu	37	16	28117727	28117727	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:28117727C>T	ENST00000304658.5	-	19	3089	c.2589G>A	c.(2587-2589)caG>caA	p.Q863Q	XPO6_ENST00000565698.1_Silent_p.Q849Q	NM_015171.3	NP_055986.1	Q96QU8	XPO6_HUMAN	exportin 6	863					protein export from nucleus		protein binding|protein transporter activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25						TGAGGAAAGTCTGTATGATTT	0.458000													12	52					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204423848	204423848	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:204423848C>T	ENST00000367187.3	-	13	2571	c.2015G>A	c.(2014-2016)cGa>cAa	p.R672Q	PIK3C2B_ENST00000496872.1_5'UTR|PIK3C2B_ENST00000424712.2_Missense_Mutation_p.R672Q	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	672					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GTGAGCTCTTCGGGTCTGCAG	0.572000													8	76					0	0	1	0	0
BARD1	580	broad.mit.edu	37	2	215661801	215661801	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:215661801C>G	ENST00000260947.4	-	2	333	c.199G>C	c.(199-201)Gag>Cag	p.E67Q	BARD1_ENST00000449967.2_5'UTR|BARD1_ENST00000471787.1_Intron	NM_000465.2|NM_001282543.1|NM_001282545.1|NM_001282548.1	NP_000456.2|NP_001269472.1|NP_001269474.1|NP_001269477.1	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	67	Interaction with BRCA1.				cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(2)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|prostate(4)|upper_aerodigestive_tract(1)	35		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AAGATGTGCTCACATCCTCCT	0.318000									Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				17	112					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44071008	44071008	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:44071008A>C	ENST00000359947.4	+	18	3623	c.3283A>C	c.(3283-3285)Aca>Cca	p.T1095P	PTPRF_ENST00000438120.1_Missense_Mutation_p.T1086P|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372413.3_Missense_Mutation_p.T1086P|PTPRF_ENST00000372414.3_Missense_Mutation_p.T1095P|PTPRF_ENST00000422171.2_Missense_Mutation_p.T443P	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1095	Fibronectin type-III 8.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GTCCATCCGCACAGCCCCCGA	0.632000													7	28					0	0	1	0	0
TMEM41A	90407	broad.mit.edu	37	3	185209349	185209349	+	Silent	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:185209349A>G	ENST00000421852.1	-	5	866	c.771T>C	c.(769-771)caT>caC	p.H257H	TMEM41A_ENST00000296254.3_3'UTR|TMEM41A_ENST00000475480.1_Intron	NM_080652.3	NP_542383.1	Q96HV5	TM41A_HUMAN	transmembrane protein 41A	257						integral to membrane				large_intestine(1)|lung(2)|skin(1)	4	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TACTGTGTATATGATTAGCAG	0.403000													6	45					0	0	1	0	0
PARVG	64098	broad.mit.edu	37	22	44602202	44602202	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr22:44602202G>A	ENST00000444313.3	+	14	1376	c.892G>A	c.(892-894)Gtg>Atg	p.V298M	PARVG_ENST00000422871.1_Missense_Mutation_p.V298M|PARVG_ENST00000415224.1_Missense_Mutation_p.V298M	NM_022141.5	NP_071424.1	Q9HBI0	PARVG_HUMAN	parvin, gamma		CH 2.				cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(10)	17		Ovarian(80;0.024)|all_neural(38;0.0299)				CGCAGATATCGTGAACAAGGA	0.592000													3	24					0	0	1	0	0
RNF168	165918	broad.mit.edu	37	3	196198909	196198909	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:196198909G>A	ENST00000318037.3	-	6	2091	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F		NM_152617.3	NP_689830.2	Q8IYW5	RN168_HUMAN	ring finger protein 168, E3 ubiquitin protein ligase	499					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)	20	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		TTTGCCTTTTGAAGTTCCCAT	0.448000													69	206					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256399	140256399	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:140256399G>A	ENST00000398631.2	+	1	1342	c.1342G>A	c.(1342-1344)Gtg>Atg	p.V448M	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018903.2|NM_031864.2	NP_061726.1|NP_114070.1												p.V448M(1)		NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGCCGACGTGAACGACAA	0.657000													10	68					0	0	1	0	0
ATP5B	506	broad.mit.edu	37	12	57037255	57037255	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:57037255C>A	ENST00000262030.3	-	5	774	c.724G>T	c.(724-726)Gaa>Taa	p.E242*	ATP5B_ENST00000552919.1_Nonsense_Mutation_p.E242*	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	242					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TCATTGCCTTCACGGGTCCTC	0.433000													16	76					1.15088e-07	1.219e-07	1	1	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	51					0	0	1	0	0
THYN1	29087	broad.mit.edu	37	11	134120220	134120220	+	Silent	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:134120220G>C	ENST00000341541.3	-	3	701	c.240C>G	c.(238-240)ctC>ctG	p.L80L	THYN1_ENST00000392594.3_Silent_p.L80L|THYN1_ENST00000392595.2_Silent_p.L80L|THYN1_ENST00000352327.5_Silent_p.L80L	NM_014174.2	NP_054893.1	Q9P016	THYN1_HUMAN	thymocyte nuclear protein 1	80						nucleus				endometrium(2)|kidney(1)|lung(3)|pancreas(1)	7	all_hematologic(175;0.127)	all_cancers(12;1.1e-21)|all_epithelial(12;3.77e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;1.68e-10)|all cancers(11;1.95e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00148)|Lung(977;0.207)		GCTGTGCTTTGAGATCCTCAA	0.478000													5	38					0	0	1	0	0
NFKBIZ	64332	broad.mit.edu	37	3	101573905	101573905	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:101573905G>A	ENST00000326172.5	+	7	1558		c.e7-1		NFKBIZ_ENST00000394054.2_Splice_Site|NFKBIZ_ENST00000326151.5_Splice_Site	NM_031419.3	NP_113607.1	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.?(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24						GATATCCACAGAGTGCCTTTC	0.438000													8	21					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5478390	5478390	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr18:5478390G>A	ENST00000341928.2	-	3	571	c.231C>T	c.(229-231)ctC>ctT	p.L77L	EPB41L3_ENST00000544123.1_Silent_p.L77L|EPB41L3_ENST00000342933.3_Silent_p.L77L|EPB41L3_ENST00000400111.3_Silent_p.L77L|RP11-286N3.1_ENST00000577527.1_RNA|EPB41L3_ENST00000540638.2_Silent_p.L77L	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	77					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						GCTGATATTCGAGCTGTTTTG	0.398000													6	49					0	0	1	0	0
CAPN1	823	broad.mit.edu	37	11	64950958	64950958	+	Silent	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:64950958C>G	ENST00000527323.1	+	3	591	c.351C>G	c.(349-351)ctC>ctG	p.L117L	CAPN1_ENST00000524773.1_Silent_p.L117L|CAPN1_ENST00000279247.6_Silent_p.L117L|CAPN1_ENST00000527469.1_3'UTR|CAPN1_ENST00000533820.1_Silent_p.L117L|CAPN1_ENST00000533129.1_Silent_p.L117L			P07384	CAN1_HUMAN	calpain 1, (mu/I) large subunit	117	Calpain catalytic.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		ACTGCTGGCTCTTGGCGGCCA	0.632000													4	20					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37881132	37881132	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:37881132G>C	ENST00000406381.2	+	22	2881	c.2371G>C	c.(2371-2373)Gac>Cac	p.D791H	ERBB2_ENST00000445658.2_Missense_Mutation_p.D545H|ERBB2_ENST00000269571.5_Missense_Mutation_p.D821H|ERBB2_ENST00000541774.1_Missense_Mutation_p.D806H|ERBB2_ENST00000584450.1_Missense_Mutation_p.D821H|ERBB2_ENST00000540147.1_Missense_Mutation_p.D791H|ERBB2_ENST00000584601.1_Missense_Mutation_p.D791H	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	821	Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.D821Y(1)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GGGCTCCCAGGACCTGCTGAA	0.587000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			8	22					0	0	1	0	0
ZCWPW1	55063	broad.mit.edu	37	7	100002662	100002662	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:100002662G>A	ENST00000398027.2	-	13	1472	c.1225C>T	c.(1225-1227)Caa>Taa	p.Q409*	ZCWPW1_ENST00000324725.6_Nonsense_Mutation_p.Q289*|ZCWPW1_ENST00000360951.4_Nonsense_Mutation_p.Q410*|ZCWPW1_ENST00000490721.1_Nonsense_Mutation_p.Q289*	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	409							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCTGCCTCTTGAGCCATCATC	0.463000													31	114					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67664936	67664936	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr15:67664936G>A	ENST00000335894.4	+	9	1307	c.1241G>A	c.(1240-1242)cGa>cAa	p.R414Q	IQCH_ENST00000358767.3_Missense_Mutation_p.R241Q|IQCH_ENST00000546225.1_Missense_Mutation_p.R162Q|IQCH_ENST00000360277.4_Missense_Mutation_p.R166Q	NM_001031715.2	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H	414										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		CATAAGACTCGACTAAAGAAG	0.448000													25	87					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87810920	87810920	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:87810920G>C	ENST00000398204.4	+	27	2724	c.2401G>C	c.(2401-2403)Ggt>Cgt	p.G801R	ADAM22_ENST00000398201.4_Splice_Site_p.G837R|ADAM22_ENST00000315984.7_Splice_Site_p.G801R|ADAM22_ENST00000398209.3_Splice_Site_p.G801R|ADAM22_ENST00000265727.7_Splice_Site_p.G837R	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	837					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CTCTTGGCAAGGTAGAGGCTG	0.418000													8	28					0	0	1	0	0
SIX1	6495	broad.mit.edu	37	14	61113247	61113247	+	Silent	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:61113247G>C	ENST00000247182.6	-	2	881	c.609C>G	c.(607-609)ctC>ctG	p.L203L	SIX1_ENST00000554986.1_Silent_p.L30L	NM_005982.3	NP_005973.1	Q15475	SIX1_HUMAN	SIX homeobox 1	203					branching involved in ureteric bud morphogenesis|embryonic cranial skeleton morphogenesis|epithelial cell differentiation|inner ear morphogenesis|mesonephric tubule formation|metanephric mesenchyme development|myoblast migration|negative regulation of neuron apoptosis|organ induction|pattern specification process|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|protein localization to nucleus|regulation of branch elongation involved in ureteric bud branching|regulation of neuron differentiation|skeletal muscle tissue development|thymus development|thyroid gland development	nucleolus|transcription factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.0201)		CCAGAGGAGAGAGTTGGTTCT	0.458000													10	44					0	0	1	0	0
LINC00610	399879	broad.mit.edu	37	11	36293257	36293257	+	RNA	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:36293257G>C	ENST00000355500.1	-	0	314																											ATGGCATCAGGTACCAAGATT	0.493000													4	10					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578268	7578268	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:7578268A>T	ENST00000420246.2	-	6	713	c.581T>A	c.(580-582)cTt>cAt	p.L194H	TP53_ENST00000359597.4_Missense_Mutation_p.L194H|TP53_ENST00000269305.4_Missense_Mutation_p.L194H|TP53_ENST00000574684.1_Intron|TP53_ENST00000413465.2_Missense_Mutation_p.L194H|TP53_ENST00000455263.2_Missense_Mutation_p.L194H|TP53_ENST00000445888.2_Missense_Mutation_p.L194H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	194	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		L -> F (in sporadic cancers; somatic mutation).|L -> H (in sporadic cancers; somatic mutation).|L -> I (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L194R(47)|p.L194P(8)|p.L194H(8)|p.0?(8)|p.?(6)|p.L101R(5)|p.L62R(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.L194fs*15(1)|p.L194fs*14(1)|p.L101H(1)|p.L194fs*52(1)|p.P98_E105>Q(1)|p.A189fs*53(1)|p.L62H(1)|p.I195fs*52(1)|p.H193_I195>AP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACTCGGATAAGATGCTGAGG	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			3	17					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24523498	24523498	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:24523498C>T	ENST00000342740.5	+	4	388	c.234C>T	c.(232-234)ctC>ctT	p.L78L	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	78										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		TCAACACGCTCAGTCAGAATC	0.592000													5	42					0	0	1	0	0
LRRC37A2	474170	broad.mit.edu	37	17	44626463	44626463	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:44626463A>G	ENST00000576629.1	+	10	4453	c.3958A>G	c.(3958-3960)Aaa>Gaa	p.K1320E	ARL17A_ENST00000573185.1_Intron|ARL17A_ENST00000329240.4_Intron|ARL17A_ENST00000445552.2_Intron|ARL17A_ENST00000337845.7_Intron|LRRC37A2_ENST00000333412.3_Missense_Mutation_p.K1320E			A6NM11	L37A2_HUMAN	leucine rich repeat containing 37, member A2	1320						integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|pancreas(4)|prostate(2)	15		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		CAGAACACCCAAAGTCAAAAA	0.438000													16	123					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141285796	141285796	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr8:141285796C>G	ENST00000389328.4	-	15	2547	c.2533G>C	c.(2533-2535)Gag>Cag	p.E845Q	TRAPPC9_ENST00000389327.3_Missense_Mutation_p.E738Q|TRAPPC9_ENST00000438773.2_Missense_Mutation_p.E747Q	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	747					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						TCCAGTTTCTCCAATGGTTCC	0.373000													6	37					0	0	1	0	0
PLEKHB2	55041	broad.mit.edu	37	2	131890540	131890540	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:131890540G>A	ENST00000403716.1	+	6	959	c.399G>A	c.(397-399)acG>acA	p.T133T	PLEKHB2_ENST00000303908.3_Silent_p.T133T|PLEKHB2_ENST00000409279.1_Silent_p.T133T|PLEKHB2_ENST00000234115.6_Silent_p.T133T|PLEKHB2_ENST00000409158.1_Silent_p.T133T|PLEKHB2_ENST00000439822.2_Intron|PLEKHB2_ENST00000438882.2_Silent_p.T133T|PLEKHB2_ENST00000538982.1_Silent_p.T85T|PLEKHB2_ENST00000404460.1_Silent_p.T133T|PLEKHB2_ENST00000409612.1_Silent_p.T133T	NM_001100623.1|NM_001267062.1|NM_001267063.1|NM_001267064.1|NM_001267065.1|NM_001267066.1|NM_017958.2	NP_001094093.1|NP_001253991.1|NP_001253992.1|NP_001253993.1|NP_001253994.1|NP_001253995.1|NP_060428.2	Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	133						membrane	protein binding	p.T133T(2)		large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		CACCATACACGGCCTATGCTG	0.572000													5	26					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123852642	123852642	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:123852642C>G	ENST00000373855.1	+	4	567	c.307C>G	c.(307-309)Ctg>Gtg	p.L103V	CNTRL_ENST00000373865.2_Missense_Mutation_p.L103V|CNTRL_ENST00000238341.5_Missense_Mutation_p.L103V			Q7Z7A1	CNTRL_HUMAN	centriolin	103					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GATAAAATCTCTGAACCTTTC	0.328000													30	46					0	0	1	0	0
G3BP2	9908	broad.mit.edu	37	4	76582796	76582796	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr4:76582796G>T	ENST00000359707.4	-	4	1081	c.296C>A	c.(295-297)tCt>tAt	p.S99Y	G3BP2_ENST00000395719.3_Missense_Mutation_p.S99Y|G3BP2_ENST00000357854.3_Missense_Mutation_p.S99Y|G3BP2_ENST00000502654.1_5'UTR	NM_203505.2	NP_987101.1	Q9UN86	G3BP2_HUMAN	GTPase activating protein (SH3 domain) binding protein 2	99	NTF2.				cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	27			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TCCACTGTTAGACAGCAAACC	0.388000													6	78					5.9392e-07	6.25179e-07	1	1	0
RIMS4	140730	broad.mit.edu	37	20	43386371	43386371	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr20:43386371C>T	ENST00000372851.3	-	4	457	c.391G>A	c.(391-393)Gag>Aag	p.E131K	RIMS4_ENST00000541604.2_Missense_Mutation_p.E132K	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	131	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				ATGTCCACCTCCAACTGACCG	0.592000													6	52					0	0	1	0	0
LCMT1	51451	broad.mit.edu	37	16	25180478	25180478	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:25180478C>T	ENST00000399069.3	+	8	891	c.736C>T	c.(736-738)Cgg>Tgg	p.R246W	LCMT1_ENST00000380966.4_Missense_Mutation_p.R191W|LCMT1_ENST00000572869.1_3'UTR	NM_016309.2	NP_057393.2	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1	246							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity								GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	TGAAAACCTGCGGAGACGCCA	0.483000													11	55					0	0	1	0	0
SWAP70	23075	broad.mit.edu	37	11	9715828	9715828	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:9715828G>A	ENST00000318950.6	+	2	338	c.235G>A	c.(235-237)Gaa>Aaa	p.E79K	SWAP70_ENST00000447399.2_Missense_Mutation_p.E79K	NM_015055.2	NP_055870.2	Q9UH65	SWP70_HUMAN	SWAP switching B-cell complex 70kDa subunit	79						cytoplasm|lamellipodium|nucleus|plasma membrane	calcium ion binding|DNA binding			NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	11				all cancers(16;1.21e-10)|Epithelial(150;2.81e-09)|BRCA - Breast invasive adenocarcinoma(625;0.00649)		GTTCATTTTGGAAAAGGTATG	0.453000													19	80					0	0	1	0	0
BTN3A3	10384	broad.mit.edu	37	6	26444277	26444277	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:26444277G>T	ENST00000244519.2	+	4	421	c.178G>T	c.(178-180)Gca>Tca	p.A60S	BTN3A3_ENST00000361232.3_Missense_Mutation_p.A18S|BTN3A3_ENST00000339789.4_Missense_Mutation_p.A18S	NM_006994.4	NP_008925.1	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3	60	Ig-like V-type 1.					integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						GACCATGAGTGCAGAGACCAT	0.572000													5	94					5.68852e-11	6.08207e-11	1	1	0
OR5B21	219968	broad.mit.edu	37	11	58275518	58275518	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:58275518G>T	ENST00000360374.2	-	1	60	c.61C>A	c.(61-63)Ctt>Att	p.L21I		NM_001005218.1	NP_001005218.1	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B, member 21	21					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GGTATCTGAAGATTGGGGTCA	0.468000													8	34					5.4927e-09	5.836e-09	1	1	0
PAAF1	80227	broad.mit.edu	37	11	73610216	73610216	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:73610216G>A	ENST00000544909.1	+	3	568	c.311G>A	c.(310-312)aGa>aAa	p.R104K	PAAF1_ENST00000536003.1_Missense_Mutation_p.R86K|PAAF1_ENST00000544552.1_Missense_Mutation_p.R86K|PAAF1_ENST00000543079.1_3'UTR|PAAF1_ENST00000535604.1_5'UTR|PAAF1_ENST00000376384.5_Missense_Mutation_p.R86K|PAAF1_ENST00000541951.1_5'UTR|PAAF1_ENST00000310571.3_Missense_Mutation_p.R103K			Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	103					interspecies interaction between organisms	proteasome complex	protein binding	p.G105delG(1)		breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(11;7.42e-05)					ATTTCCAGCAGAGGAGGTCTT	0.383000													6	28					0	0	1	0	0
NUP160	23279	broad.mit.edu	37	11	47827865	47827865	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:47827865C>T	ENST00000378460.2	-	20	2493		c.e20-1		NUP160_ENST00000530326.1_Splice_Site|NUP160_ENST00000528071.1_Splice_Site	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						GGACTAGATACTTAAAAAGAA	0.323000													4	24					0	0	1	0	0
RIMBP3	85376	broad.mit.edu	37	22	20458133	20458133	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr22:20458133C>T	ENST00000426804.1	-	1	3653	c.3169G>A	c.(3169-3171)Gag>Aag	p.E1057K		NM_015672.1	NP_056487.1			RIMS binding protein 3											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			AGCCGCACCTCCACCCGCGCC	0.642000													3	21					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74305039	74305039	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:74305039C>G	ENST00000377044.4	-	22	4359	c.3820G>C	c.(3820-3822)Gaa>Caa	p.E1274Q	TMEM2_ENST00000377066.5_Missense_Mutation_p.E1211Q|TMEM2_ENST00000396272.3_Missense_Mutation_p.E267Q	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	1274						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AAATACTCTTCAATGCGACTG	0.483000													56	77					0	0	1	0	0
PAN2	9924	broad.mit.edu	37	12	56721411	56721411	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:56721411G>A	ENST00000425394.2	-	6	1032	c.656C>T	c.(655-657)tCc>tTc	p.S219F	PAN2_ENST00000257931.5_Missense_Mutation_p.S219F|PAN2_ENST00000440411.3_Missense_Mutation_p.S219F|PAN2_ENST00000548043.1_Missense_Mutation_p.S219F	NM_001127460.2	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	219					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						GTCTCTCAGGGAAACCTAGAA	0.448000													3	41					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27803987	27803987	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:27803987C>G	ENST00000408964.2	+	1	4599	c.4548C>G	c.(4546-4548)atC>atG	p.I1516M		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1516										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					GAGGAAGAATCCTACCTGGTT	0.483000													5	40					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29086403	29086403	+	RNA	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:29086403C>T	ENST00000564580.1	+	0	107																											GCGGCCGCTTCGCCCTCTGCA	0.642000													4	4					0	0	1	0	0
MAPKAP1	79109	broad.mit.edu	37	9	128201227	128201227	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:128201227C>G	ENST00000265960.3	-	12	1840	c.1508G>C	c.(1507-1509)aGa>aCa	p.R503T	MAPKAP1_ENST00000373511.2_Missense_Mutation_p.R456T|MAPKAP1_ENST00000394063.1_Missense_Mutation_p.R311T|MAPKAP1_ENST00000373503.3_Missense_Mutation_p.R311T|MAPKAP1_ENST00000350766.3_Missense_Mutation_p.R467T|MAPKAP1_ENST00000373498.1_Missense_Mutation_p.R503T|MAPKAP1_ENST00000373497.5_Missense_Mutation_p.R216T|MAPKAP1_ENST00000483937.1_5'UTR	NM_001006617.1	NP_001006618.1	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated protein 1	503	Interaction with ATF2.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(15)|ovary(3)	23						GTTCAGTTTTCTTTGTTTTTG	0.522000													58	45					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20986704	20986704	+	Nonsense_Mutation	SNP	G	G	A	rs150583804		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:20986704G>A	ENST00000261383.3	-	51	8109	c.8110C>T	c.(8110-8112)Caa>Taa	p.Q2704*	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2704	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGTTGAGGTTGAAGAGCTGTC	0.478000													12	74					0	0	1	0	0
EIF2S3	1968	broad.mit.edu	37	X	24086096	24086096	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:24086096G>A	ENST00000253039.4	+	9	1136	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K		NM_001415.3	NP_001406.1	P41091	IF2G_HUMAN	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	295						cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(1)	12						CCAGGAGATAGAAGTAAGACC	0.353000													15	92					0	0	1	0	0
LRRFIP1	9208	broad.mit.edu	37	2	238671322	238671322	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:238671322G>A	ENST00000244815.5	+	10	1134	c.894G>A	c.(892-894)gaG>gaA	p.E298E	LRRFIP1_ENST00000289175.6_Silent_p.E266E|LRRFIP1_ENST00000308482.9_Intron|LRRFIP1_ENST00000392000.4_Silent_p.E322E	NM_004735.3	NP_004726.2	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1	322					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		ACAATACTGAGAAAGAACAAC	0.443000													8	33					0	0	1	0	0
DHX36	170506	broad.mit.edu	37	3	154042138	154042138	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:154042138C>G	ENST00000496811.1	-	1	148	c.68G>C	c.(67-69)gGa>gCa	p.G23A	DHX36_ENST00000329463.5_Missense_Mutation_p.G23A|DHX36_ENST00000544526.1_Missense_Mutation_p.G23A|DHX36_ENST00000308361.6_Missense_Mutation_p.G23A	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	23	Gly-rich.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGGCCCCCCTCCATAGCCCCC	0.692000													3	14					0	0	1	0	0
SEPSECS	51091	broad.mit.edu	37	4	25157673	25157673	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr4:25157673G>A	ENST00000382103.2	-	4	605	c.533C>T	c.(532-534)tCc>tTc	p.S178F	SEPSECS_ENST00000302922.3_Missense_Mutation_p.S99F	NM_016955.3	NP_058651.3	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	178					selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding			endometrium(1)|large_intestine(4)|lung(2)|stomach(1)	8		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	AGTGATCATGGATTTAAAGCA	0.308000													8	57					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127485735	127485735	+	Silent	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:127485735A>G	ENST00000262461.2	+	13	2241	c.2052A>G	c.(2050-2052)gcA>gcG	p.A684A	SLC12A2_ENST00000343225.4_Silent_p.A684A	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	684					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCTTCCTTGCATCATATGCAT	0.299000													5	79					0	0	1	0	0
IGHV3-30	28439	broad.mit.edu	37	14	106791144	106791144	+	RNA	SNP	G	G	A	rs71278954		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:106791144G>A	ENST00000390613.2	-	0	291																											TCCATCATATGATATAACTGC	0.507000													14	182					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44922802	44922802	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:44922802C>T	ENST00000377967.4	+	16	1704	c.1663C>T	c.(1663-1665)Cag>Tag	p.Q555*	KDM6A_ENST00000382899.4_Nonsense_Mutation_p.Q562*|KDM6A_ENST00000536777.1_Nonsense_Mutation_p.Q510*|KDM6A_ENST00000543216.1_Nonsense_Mutation_p.Q476*	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	555					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.0(2)|p.Q555*(2)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TAGCGTCTCTCAGCCTGGAGT	0.567000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								4	25					0	0	1	0	0
SRD5A1	6715	broad.mit.edu	37	5	6633847	6633847	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:6633847G>A	ENST00000274192.5	+	1	392	c.158G>A	c.(157-159)cGg>cAg	p.R53Q	SRD5A1_ENST00000504286.1_3'UTR|SRD5A1_ENST00000538824.1_Missense_Mutation_p.G62R|SRD5A1_ENST00000537411.1_Missense_Mutation_p.G62R	NM_001047.2	NP_001038.1	P18405	S5A1_HUMAN	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	53				Missing (in Ref. 4; AAF14869).	androgen biosynthetic process|cell differentiation|sex determination|sex differentiation	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|electron carrier activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19					Dutasteride(DB01126)|Finasteride(DB01216)	GTGCCGGCGCGGGCCGCCTGG	0.731000													7	7					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159183182	159183182	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:159183182G>C	ENST00000297239.9	+	15	1683	c.1489G>C	c.(1489-1491)Gat>Cat	p.D497H	SYTL3_ENST00000360448.3_Missense_Mutation_p.D429H|SYTL3_ENST00000367081.3_Missense_Mutation_p.D223H			Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	497	C2 2.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TGTGCGGCCAGATGGCACCTT	0.443000													7	31					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94933616	94933616	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:94933616C>T	ENST00000337425.5	-	3	860	c.786G>A	c.(784-786)gaG>gaA	p.E262E	SERPINA9_ENST00000448305.2_Silent_p.E164E|SERPINA9_ENST00000298845.7_Silent_p.E162E|SERPINA9_ENST00000380365.3_Silent_p.E244E|SERPINA9_ENST00000424550.2_Silent_p.E113E|SERPINA9_ENST00000546329.1_Silent_p.E226E	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	244					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		AAGCGAACTGCTCTTTCTGGT	0.522000													4	23					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99662162	99662162	+	Silent	SNP	G	G	A	rs137962077	by1000genomes	TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:99662162G>A	ENST00000373034.4	-	1	3109	c.1434C>T	c.(1432-1434)cgC>cgT	p.R478R	PCDH19_ENST00000420881.2_Silent_p.R478R|PCDH19_ENST00000255531.7_Silent_p.R478R	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	478	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						GGTCGGGGTCGCGAGCAGACA	0.567000													6	39					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51096798	51096798	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:51096798T>A	ENST00000395542.2	-	12	2425	c.2241A>T	c.(2239-2241)agA>agT	p.R747S	COBL_ENST00000265136.7_Missense_Mutation_p.R665S			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	665										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					GGGAATTCACTCTCTCTGTGG	0.478000													4	77					0	0	1	0	0
ACSBG2	81616	broad.mit.edu	37	19	6166014	6166014	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:6166014C>T	ENST00000588304.1	+	7	1022	c.576C>T	c.(574-576)ctC>ctT	p.L192L	ACSBG2_ENST00000591741.1_3'UTR|ACSBG2_ENST00000588485.1_Silent_p.L55L|ACSBG2_ENST00000586696.1_Silent_p.L242L|ACSBG2_ENST00000252669.5_Silent_p.L242L|ACSBG2_ENST00000591403.1_Silent_p.L242L			Q5FVE4	ACBG2_HUMAN	acyl-CoA synthetase bubblegum family member 2	242					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(3)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GAGTGATGCTCAGTCATGACA	0.557000											OREG0025194	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	26					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95111296	95111296	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr10:95111296G>C	ENST00000371501.4	-	34	3818	c.3696C>G	c.(3694-3696)ttC>ttG	p.F1232L	MYOF_ENST00000358334.5_Missense_Mutation_p.F1219L|MYOF_ENST00000359263.4_Missense_Mutation_p.F1232L|MYOF_ENST00000371502.4_Missense_Mutation_p.F1232L			Q9NZM1	MYOF_HUMAN	myoferlin	1232					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CCACAGGAGAGAAAATGCTTC	0.433000													19	43					0	0	1	0	0
PEX6	5190	broad.mit.edu	37	6	42946153	42946153	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:42946153C>T	ENST00000304611.8	-	1	805	c.736G>A	c.(736-738)Gaa>Aaa	p.E246K	PEX6_ENST00000244546.4_Missense_Mutation_p.E246K	NM_000287.3	NP_000278.3	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	246					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(3)	15			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			CAGCGAGGTTCTAGGACCTGC	0.637000													10	27					0	0	1	0	0
ZNF551	90233	broad.mit.edu	37	19	58199365	58199365	+	Silent	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:58199365C>G	ENST00000282296.5	+	3	1907	c.1722C>G	c.(1720-1722)ctC>ctG	p.L574L	ZNF551_ENST00000356715.4_Silent_p.L558L|AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000594684.1_Intron|ZNF551_ENST00000596085.1_Intron			Q7Z340	ZN551_HUMAN	zinc finger protein 551	574					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTGCTAGCCTCATTCAACACC	0.468000													24	86					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241570154	241570154	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:241570154G>C	ENST00000319838.5	+	6	1727	c.785G>C	c.(784-786)aGc>aCc	p.S262T	GPR35_ENST00000438013.2_Missense_Mutation_p.S293T|GPR35_ENST00000407714.1_Missense_Mutation_p.S262T|GPR35_ENST00000403859.1_Missense_Mutation_p.S262T|GPR35_ENST00000430267.1_Missense_Mutation_p.S262T	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	262						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		TACATAACCAGCAAGCTCTCA	0.632000													8	66					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50314000	50314000	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr20:50314000G>A	ENST00000338821.5	-	5	722	c.458C>T	c.(457-459)tCt>tTt	p.S153F	ATP9A_ENST00000402822.1_Intron|ATP9A_ENST00000311637.5_Intron	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	153					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TTGGATGTTAGAACTCTTCAC	0.438000													39	80					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123847425	123847425	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr10:123847425C>T	ENST00000369005.1	+	4	5750	c.5410C>T	c.(5410-5412)Cac>Tac	p.H1804Y	TACC2_ENST00000358010.1_Intron|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515273.1_Missense_Mutation_p.H1804Y|TACC2_ENST00000453444.2_Missense_Mutation_p.H1804Y|TACC2_ENST00000515603.1_Missense_Mutation_p.H1804Y|TACC2_ENST00000334433.3_Missense_Mutation_p.H1804Y	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1804						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TGACGAAACTCACGACCCGAA	0.562000													10	30					0	0	1	0	0
DHX36	170506	broad.mit.edu	37	3	154042035	154042035	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:154042035C>T	ENST00000496811.1	-	1	251	c.171G>A	c.(169-171)ctG>ctA	p.L57L	DHX36_ENST00000329463.5_Silent_p.L57L|DHX36_ENST00000544526.1_Silent_p.L57L|DHX36_ENST00000308361.6_Silent_p.L57L	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	57	Gly-rich.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CGCGGCCTTTCAGGTGCCCGG	0.652000													14	86					0	0	1	0	0
XKRX	402415	broad.mit.edu	37	X	100170026	100170026	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:100170026G>A	ENST00000468904.1	-	2	1510	c.382C>T	c.(382-384)Cct>Tct	p.P128S	XKRX_ENST00000328526.5_Silent_p.T230T|XKRX_ENST00000372956.2_Silent_p.T217T			Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related, X-linked	0						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(3)	22						TATTGCAAAGGGTGGCCCCAT	0.433000													4	45					0	0	1	0	0
TTF2	8458	broad.mit.edu	37	1	117638919	117638919	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:117638919C>T	ENST00000369466.4	+	20	3228	c.3184C>T	c.(3184-3186)Cag>Tag	p.Q1062*		NM_003594.3	NP_003585.3	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase II		Helicase C-terminal.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(24)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	50	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		CAGAGGCCCTCAGGTACAAGC	0.433000													8	29					0	0	1	0	0
C1orf109	54955	broad.mit.edu	37	1	38149000	38149000	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:38149000G>C	ENST00000358011.4	-	4	754	c.565C>G	c.(565-567)Ctt>Gtt	p.L189V	C1orf109_ENST00000464085.1_Missense_Mutation_p.L189V|C1orf109_ENST00000609516.1_5'UTR	NM_017850.1	NP_060320.1	Q9NX04	CA109_HUMAN	chromosome 1 open reading frame 109	189										lung(2)|prostate(2)	4		Myeloproliferative disorder(586;0.0393)				CCTTGTACAAGATCTTGGTGT	0.483000													19	70					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11741061	11741061	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:11741061G>C	ENST00000381486.2	+	16	2769	c.2469G>C	c.(2467-2469)caG>caC	p.Q823H	GREB1_ENST00000234142.5_Missense_Mutation_p.Q823H	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	823						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ATGCACTGCAGACACAGCACA	0.582000													11	47					0	0	1	0	0
PMS2	5395	broad.mit.edu	37	7	6035197	6035197	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:6035197A>T	ENST00000265849.7	-	8	976	c.871T>A	c.(871-873)Ttt>Att	p.F291I	PMS2_ENST00000469652.1_Intron|PMS2_ENST00000382321.4_Intron|PMS2_ENST00000406569.3_Missense_Mutation_p.F291I|PMS2_ENST00000441476.2_Missense_Mutation_p.F185I	NM_000535.5	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	291					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CGGTTGATAAAGAAAAACTGT	0.368000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				9	91					0	0	1	0	0
METTL8	79828	broad.mit.edu	37	2	172187201	172187201	+	Missense_Mutation	SNP	G	G	A	rs142842112	byFrequency	TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:172187201G>A	ENST00000375258.4	-	7	943	c.728C>T	c.(727-729)tCg>tTg	p.S243L		NM_024770.3	NP_079046.2	B3KW44	B3KW44_HUMAN	methyltransferase like 8								methyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	11						TCTGTAGGACGAGTGTGACTG	0.378000													6	39					0	0	1	0	0
AASDHPPT	60496	broad.mit.edu	37	11	105962117	105962117	+	Silent	SNP	A	A	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:105962117A>C	ENST00000278618.4	+	4	828	c.606A>C	c.(604-606)ctA>ctC	p.L202L	RP11-677I18.3_ENST00000532422.1_RNA	NM_015423.2	NP_056238.2	Q9NRN7	ADPPT_HUMAN	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	202					macromolecule biosynthetic process|pantothenate metabolic process	cytosol	holo-[acyl-carrier-protein] synthase activity|magnesium ion binding|protein binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)	17		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.78e-05)|Epithelial(105;0.00622)|all cancers(92;0.041)		AATTTGATCTATCTCCATTAA	0.363000													9	65					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55638880	55638880	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:55638880G>A	ENST00000370830.3	-	4	1692	c.994C>T	c.(994-996)Cat>Tat	p.H332Y	BMP5_ENST00000446683.2_Missense_Mutation_p.H332Y	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	332					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GAGTCCTGATGAGAGCTGGAT	0.468000													13	89					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232568191	232568191	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:232568191G>A	ENST00000366630.1	-	15	4416	c.4058C>T	c.(4057-4059)tCa>tTa	p.S1353L	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.S1353L|SIPA1L2_ENST00000308942.4_Missense_Mutation_p.S427L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1353	Ser-rich.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				ACAGTGAGCTGAAGGGCTTCC	0.498000													12	32					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534481	92534481	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:92534481G>A	ENST00000298047.6	+	9	8319	c.8302G>A	c.(8302-8304)Gac>Aac	p.D2768N	FAT3_ENST00000525166.1_Missense_Mutation_p.D2618N|FAT3_ENST00000409404.2_Missense_Mutation_p.D2768N			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2768	Cadherin 25.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TATTAAGCTTGACAAACGCCT	0.453000										TCGA Ovarian(4;0.039)			12	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179590656	179590656	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:179590656T>A	ENST00000589042.1	-	70	20617	c.20393A>T	c.(20392-20394)aAg>aTg	p.K6798M	TTN_ENST00000591111.1_Missense_Mutation_p.K6481M|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.K5554M	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6481	Ig-like 49.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGTTGCCGCTTGTCTTTGTA	0.423000													4	27					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088259	9088259	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:9088259C>T	ENST00000397910.4	-	1	3759	c.3556G>A	c.(3556-3558)Gaa>Aaa	p.E1186K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1186	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CGACTAGTTTCAACTGTGTCC	0.458000													9	63					0	0	1	0	0
FGD3	89846	broad.mit.edu	37	9	95772611	95772611	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:95772611C>T	ENST00000375482.3	+	7	1417	c.921C>T	c.(919-921)ctC>ctT	p.L307L	FGD3_ENST00000416701.2_Silent_p.L307L|FGD3_ENST00000337352.6_Silent_p.L307L	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	307	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						AGCTGCTGCTCAAGGACTATC	0.662000													12	18					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25940240	25940240	+	Silent	SNP	G	G	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr15:25940240G>T	ENST00000356865.6	-	14	2925	c.2814C>A	c.(2812-2814)ggC>ggA	p.G938G		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	938					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CTCTCTGGAGGCCTCTGGACT	0.612000													9	26					0.000978159	0.00100476	1	1	0
PIK3C3	5289	broad.mit.edu	37	18	39595442	39595442	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr18:39595442C>T	ENST00000262039.4	+	12	1414	c.1328C>T	c.(1327-1329)tCc>tTc	p.S443F	PIK3C3_ENST00000398870.3_Missense_Mutation_p.S380F	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	443					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						TTTTTCAGCTCCCAAATTATA	0.388000										TSP Lung(28;0.18)			7	37					0	0	1	0	0
COASY	80347	broad.mit.edu	37	17	40714723	40714723	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:40714723C>T	ENST00000393818.2	+	1	539	c.83C>T	c.(82-84)tCg>tTg	p.S28L	COASY_ENST00000449624.1_Intron|COASY_ENST00000421097.2_Missense_Mutation_p.S28L|COASY_ENST00000590958.1_Missense_Mutation_p.S57L|COASY_ENST00000420359.1_Missense_Mutation_p.S28L	NM_025233.6	NP_079509.5	Q13057	COASY_HUMAN	CoA synthase	28					coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)	21		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		ATCCTGACCTCGGCGGCCCGG	0.701000													3	28					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	53986424	53986424	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:53986424C>T	ENST00000312233.2	-	6	1650	c.1084G>A	c.(1084-1086)Gac>Aac	p.D362N		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	362					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GCCTCGGTGTCAGGGCCCGCA	0.652000													4	8					0	0	1	0	0
NPIPB4	440345	broad.mit.edu	37	16	21848691	21848691	+	Silent	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:21848691G>C	ENST00000451409.1	-	7	1295	c.468C>G	c.(466-468)ctC>ctG	p.L156L	NPIPB4_ENST00000357370.5_Intron|NPIPB4_ENST00000415645.2_Silent_p.L339L|NPIPB4_ENST00000537951.1_Silent_p.L123L					nuclear pore complex interacting protein family, member B4																		GAGGTGTCTTGAGTTTATCAT	0.562000													17	93					0	0	1	0	0
GNA13	10672	broad.mit.edu	37	17	63049731	63049731	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:63049731G>A	ENST00000439174.2	-	2	644	c.399C>T	c.(397-399)gcC>gcT	p.A133A	GNA13_ENST00000541118.1_Silent_p.A38A	NM_006572.4	NP_006563.2	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein), alpha 13	133					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(14)|kidney(2)|large_intestine(4)|lung(6)|urinary_tract(1)	34						CCATTCCTTGGGCTGCCATGG	0.488000													19	183					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99565820	99565820	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:99565820G>A	ENST00000411734.1	-	3	567	c.562C>T	c.(562-564)Cgg>Tgg	p.R188W	AZGP1_ENST00000292401.4_Missense_Mutation_p.R191W			P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	191					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					AGGTATTTCCGCAGAGTCGCA	0.552000													4	65					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125072431	125072431	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr8:125072431C>T	ENST00000522917.1	+	23	3091	c.2885C>T	c.(2884-2886)tCt>tTt	p.S962F	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6-AS2_ENST00000601180.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.S962F	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	962						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GTTCCTCCTTCTGGGCTGCAA	0.557000													11	44					0	0	1	0	0
C14orf105	55195	broad.mit.edu	37	14	57960354	57960354	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:57960354G>A	ENST00000216445.3	-	1	216	c.80C>T	c.(79-81)tCg>tTg	p.S27L	C14orf105_ENST00000534126.1_Missense_Mutation_p.S27L|C14orf105_ENST00000422976.2_Missense_Mutation_p.S27L|C14orf105_ENST00000526336.1_Missense_Mutation_p.S27L	NM_001283057.1|NM_018168.2	NP_001269986.1|NP_060638.2	Q9NVL8	CN105_HUMAN	chromosome 14 open reading frame 105	27										breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)	11						ACGGCCAGCCGAGGGAGTCTC	0.458000													12	51					0	0	1	0	0
MORC4	79710	broad.mit.edu	37	X	106186370	106186370	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:106186370G>C	ENST00000355610.4	-	15	2025	c.1751C>G	c.(1750-1752)aCa>aGa	p.T584R	MORC4_ENST00000535534.1_Missense_Mutation_p.T332R|MORC4_ENST00000255495.7_Missense_Mutation_p.T584R	NM_001085354.2|NM_024657.4	NP_001078823.1|NP_078933.3	Q8TE76	MORC4_HUMAN	MORC family CW-type zinc finger 4	584							ATP binding|zinc ion binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	28						AGAAGGTGTTGTCATCTCATT	0.453000													10	122					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3838515	3838515	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:3838515C>T	ENST00000309890.7	-	17	2731	c.2581G>A	c.(2581-2583)Gag>Aag	p.E861K	ATP2A3_ENST00000397039.1_Missense_Mutation_p.E45K|ATP2A3_ENST00000397043.3_Missense_Mutation_p.E861K|ATP2A3_ENST00000397035.3_Missense_Mutation_p.E861K|ATP2A3_ENST00000352011.3_Missense_Mutation_p.E861K|ATP2A3_ENST00000397041.3_Missense_Mutation_p.E861K|ATP2A3_ENST00000359983.3_Missense_Mutation_p.E861K	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	861					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		TGAGGTCCCTCGGCGTCATAC	0.597000											OREG0024094	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	15					0	0	1	0	0
ATP5B	506	broad.mit.edu	37	12	57036459	57036459	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:57036459C>G	ENST00000262030.3	-	6	999	c.949G>C	c.(949-951)Gag>Cag	p.E317Q	ATP5B_ENST00000552919.1_Intron|ATP5B_ENST00000550162.1_5'UTR	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	317					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCTCTTACCTCTGAACCAGCC	0.458000													10	33					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71493662	71493662	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:71493662G>A	ENST00000296755.7	+	5	4778	c.4480G>A	c.(4480-4482)Gaa>Aaa	p.E1494K		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1494						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GGCTCTGGATGAAAGGAAATT	0.398000													23	80					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	50					0	0	1	0	0
AGBL5	60509	broad.mit.edu	37	2	27282095	27282095	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:27282095C>T	ENST00000360131.4	+	11	2071	c.1912C>T	c.(1912-1914)Cgg>Tgg	p.R638W	AGBL5_ENST00000323064.8_Missense_Mutation_p.R638W	NM_021831.5	NP_068603.4	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5	638					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	28	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACCTTGAGTCGGGCACGAAG	0.532000													8	113					0	0	1	0	0
GTF2F1	2962	broad.mit.edu	37	19	6380394	6380394	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:6380394C>T	ENST00000394456.5	-	13	1916	c.1452G>A	c.(1450-1452)ctG>ctA	p.L484L	GTF2F1_ENST00000429701.2_Silent_p.L399L	NM_002096.2	NP_002087.2	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1, 74kDa	484					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)	16						GCTCGCTGCTCAGCCCTGTCT	0.557000													28	103					0	0	1	0	0
KIAA1731	85459	broad.mit.edu	37	11	93455128	93455128	+	Silent	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:93455128A>G	ENST00000325212.6	+	20	6021	c.5859A>G	c.(5857-5859)acA>acG	p.T1953T	KIAA1731_ENST00000531700.1_Silent_p.T133T|KIAA1731_ENST00000344196.4_Silent_p.T133T|KIAA1731_ENST00000411936.1_Silent_p.T1953T			Q9C0D2	K1731_HUMAN	KIAA1731	1953						centrosome				breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)	11		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AGGCTAAAACACTGTCTTATG	0.398000													3	28					0	0	1	0	0
ZNF214	7761	broad.mit.edu	37	11	7021225	7021225	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:7021225G>C	ENST00000278314.4	-	3	2004	c.1689C>G	c.(1687-1689)ttC>ttG	p.F563L	ZNF214_ENST00000536068.1_Missense_Mutation_p.F563L	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	563					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		AGCTATGACTGAAACCTTTAC	0.393000													14	49					0	0	1	0	0
CMAS	55907	broad.mit.edu	37	12	22208204	22208204	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:22208204G>C	ENST00000229329.2	+	2	512	c.382G>C	c.(382-384)Gaa>Caa	p.E128Q		NM_018686.4	NP_061156.1	Q8NFW8	NEUA_HUMAN	cytidine monophosphate N-acetylneuraminic acid synthetase	128					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24						TGCCATCATAGAATTTCTTAA	0.299000													7	27					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75896747	75896747	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:75896747C>T	ENST00000274364.6	+	11	1479	c.1182C>T	c.(1180-1182)ctC>ctT	p.L394L	IQGAP2_ENST00000379730.3_5'UTR	NM_006633.2	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	394					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AGAATCAACTCAGAAGCCCCG	0.448000													7	38					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97427280	97427280	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:97427280C>T	ENST00000377075.2	+	1	642	c.544C>T	c.(544-546)Ctc>Ttc	p.L182F		NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	182					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane		p.L182V(1)		breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						GTTCCTGCCTCTCTGGCTGCA	0.622000													13	75					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205568336	205568336	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:205568336C>T	ENST00000367147.4	+	9	1539	c.1446C>T	c.(1444-1446)atC>atT	p.I482I	MFSD4_ENST00000536357.1_Silent_p.I395I|MFSD4_ENST00000478555.1_3'UTR|MFSD4_ENST00000539267.1_3'UTR	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	482					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CCTTCTATATCTTGCTCCTGT	0.498000													15	86					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104742552	104742552	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:104742552G>A	ENST00000334877.4	+	17	2641	c.2107G>A	c.(2107-2109)Gaa>Aaa	p.E703K	KMT2E_ENST00000257745.4_Missense_Mutation_p.E703K|KMT2E_ENST00000334914.7_5'UTR|KMT2E_ENST00000311117.3_Missense_Mutation_p.E703K					lysine (K)-specific methyltransferase 2E																		AATAGAACCAGAAACTGAAAC	0.348000													17	61					0	0	1	0	0
SCO1	6341	broad.mit.edu	37	17	10595195	10595195	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:10595195C>A	ENST00000255390.5	-	4	709	c.649G>T	c.(649-651)Gtg>Ttg	p.V217L	SCO1_ENST00000577427.1_Missense_Mutation_p.V186L	NM_004589.2	NP_004580.1	O75880	SCO1_HUMAN	SCO1 cytochrome c oxidase assembly protein	217					cellular copper ion homeostasis|copper ion transport|generation of precursor metabolites and energy|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|urinary_tract(1)	10						ATACCTTTCACATAATTTGCG	0.348000													4	27					2.56e-06	2.66994e-06	1	1	0
TRIOBP	11078	broad.mit.edu	37	22	38121328	38121328	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr22:38121328C>G	ENST00000406386.3	+	7	3020	c.2765C>G	c.(2764-2766)tCt>tGt	p.S922C		NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	922					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CCCCGAACCTCTTCCCCATCT	0.592000													4	48					0	0	1	0	0
ZRANB3	84083	broad.mit.edu	37	2	135965023	135965023	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:135965023G>A	ENST00000401392.1	-	19	3196	c.2984C>T	c.(2983-2985)tCa>tTa	p.S995L	ZRANB3_ENST00000412849.1_5'UTR|ZRANB3_ENST00000536680.1_Missense_Mutation_p.S995L|ZRANB3_ENST00000264159.6_Missense_Mutation_p.S997L			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	997						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		TGGGAGCTTTGAAGTCCAGGT	0.383000													16	116					0	0	1	0	0
RNMTL1	55178	broad.mit.edu	37	17	694988	694988	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:694988G>A	ENST00000304478.4	+	4	1048	c.942G>A	c.(940-942)atG>atA	p.M314I		NM_018146.2	NP_060616.1	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	314					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		AACGAGTGATGAAGTTTCACA	0.493000													8	31					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102816510	102816510	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr4:102816510G>A	ENST00000504592.1	+	10	1325	c.907G>A	c.(907-909)Gag>Aag	p.E303K	BANK1_ENST00000508653.1_Missense_Mutation_p.E185K|BANK1_ENST00000428908.1_Missense_Mutation_p.E185K|BANK1_ENST00000322953.4_Missense_Mutation_p.E318K|BANK1_ENST00000444316.2_Missense_Mutation_p.E288K			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	318	DBB.			S -> R (in Ref. 4; BAF84822).	B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		ATTCAAACATGAGATACCATA	0.294000													4	58					0	0	1	0	0
RUSC1	23623	broad.mit.edu	37	1	155292593	155292593	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:155292593C>T	ENST00000368352.5	+	2	1180	c.1029C>T	c.(1027-1029)ctC>ctT	p.L343L	RUSC1-AS1_ENST00000450199.1_RNA|RUSC1-AS1_ENST00000443642.1_RNA|RUSC1_ENST00000368354.3_Silent_p.L343L	NM_001105203.1	NP_001098673.1	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1	343						cytoplasm|nucleolus	SH3/SH2 adaptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(2)|skin(1)|urinary_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			GTGACTGGCTCATAGTCTTCT	0.672000													4	13					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21993557	21993557	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:21993557G>A	ENST00000327430.3	-	2	599	c.305C>T	c.(304-306)tCt>tTt	p.S102F	SALL2_ENST00000450879.2_Missense_Mutation_p.S100F|SALL2_ENST00000538754.1_Missense_Mutation_p.S100F|SALL2_ENST00000317492.5_Missense_Mutation_p.S102F	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	102							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GGAGGACCCAGAATCTGGGGG	0.617000													8	41					0	0	1	0	0
LARP1B	55132	broad.mit.edu	37	4	129043145	129043145	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr4:129043145C>T	ENST00000326639.6	+	11	1537	c.1326C>T	c.(1324-1326)gaC>gaT	p.D442D	LARP1B_ENST00000427266.1_Silent_p.D442D|LARP1B_ENST00000512292.1_Silent_p.D442D|LARP1B_ENST00000264584.5_Silent_p.D395D|LARP1B_ENST00000354456.3_5'UTR|LARP1B_ENST00000441387.1_Silent_p.D442D	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	442							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						AAATTGATGACCAAGACTTAA	0.353000													8	47					0	0	1	0	0
RPTOR	57521	broad.mit.edu	37	17	78519457	78519457	+	Missense_Mutation	SNP	C	C	T	rs149692261		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:78519457C>T	ENST00000306801.3	+	1	390	c.28C>T	c.(28-30)Ctt>Ttt	p.L10F	RPTOR_ENST00000570891.1_Missense_Mutation_p.L10F|RPTOR_ENST00000544334.2_Missense_Mutation_p.L10F|RPTOR_ENST00000537330.1_5'UTR	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	10					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						GCAATCGCCTCTTCTGGGCCT	0.527000													6	32					0	0	1	0	0
INPP4A	3631	broad.mit.edu	37	2	99182131	99182131	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:99182131G>A	ENST00000409016.4	+	21	2476	c.2079G>A	c.(2077-2079)atG>atA	p.M693I	INPP4A_ENST00000545415.1_Missense_Mutation_p.M693I|INPP4A_ENST00000409851.3_Missense_Mutation_p.M727I|INPP4A_ENST00000409540.3_Missense_Mutation_p.M693I|INPP4A_ENST00000409463.1_Intron|INPP4A_ENST00000523221.1_Missense_Mutation_p.M732I|INPP4A_ENST00000074304.5_Missense_Mutation_p.M732I			Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa						signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						TGGAGGACATGAGCCTTGGGA	0.597000													3	36					0	0	1	0	0
AQP11	282679	broad.mit.edu	37	11	77301496	77301496	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:77301496C>T	ENST00000313578.3	+	1	817	c.459C>T	c.(457-459)ttC>ttT	p.F153F	AQP11_ENST00000528638.1_Intron	NM_173039.2	NP_766627.1	Q8NBQ7	AQP11_HUMAN	aquaporin 11	153						cell surface|integral to membrane	transporter activity			kidney(2)|large_intestine(1)|lung(5)	8	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			AGAGGAGCTTCGCTTGCAAGA	0.572000													13	23					0	0	1	0	0
RLIM	51132	broad.mit.edu	37	X	73812302	73812302	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:73812302C>T	ENST00000332687.6	-	4	1066	c.848G>A	c.(847-849)aGa>aAa	p.R283K	RLIM_ENST00000349225.2_Missense_Mutation_p.R283K	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	283					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AAAAAGACCTCTACTTAGCAA	0.473000													11	61					0	0	1	0	0
CCDC150	284992	broad.mit.edu	37	2	197541388	197541388	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:197541388G>A	ENST00000389175.4	+	12	1508	c.1373G>A	c.(1372-1374)gGt>gAt	p.G458D	CCDC150_ENST00000423093.2_Missense_Mutation_p.G126D|CCDC150_ENST00000272831.7_Missense_Mutation_p.G126D|CCDC150_ENST00000472405.2_3'UTR	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	458										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						AGATTGCGAGGTGAATTGGAA	0.408000													4	30					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51847342	51847342	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:51847342G>C	ENST00000453097.2	+	5	650	c.433G>C	c.(433-435)Gat>Cat	p.D145H	SLC4A8_ENST00000535225.2_Missense_Mutation_p.D92H|SLC4A8_ENST00000358657.3_Missense_Mutation_p.D172H|SLC4A8_ENST00000394856.1_Missense_Mutation_p.D92H|SLC4A8_ENST00000514353.3_Missense_Mutation_p.D92H	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	145					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		GTTTGAAGAAGATGTTGAAGA	0.423000													4	54					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14406742	14406742	+	Silent	SNP	C	C	T	rs147339578		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:14406742C>T	ENST00000344204.4	+	33	4944	c.4920C>T	c.(4918-4920)atC>atT	p.I1640I	TRIO_ENST00000537187.1_Silent_p.I1640I	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	1640					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					CGATTTCCATCGCCTCACGGA	0.562000													13	64					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25313651	25313651	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr22:25313651G>A	ENST00000400358.4	+	23	3012	c.2955G>A	c.(2953-2955)ctG>ctA	p.L985L	SGSM1_ENST00000400359.4_Silent_p.L1040L	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	1040	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						TGTTTGAGCTGATGCATCAGA	0.502000													5	26					0	0	1	0	0
RASA2	5922	broad.mit.edu	37	3	141272768	141272768	+	Silent	SNP	A	A	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:141272768A>C	ENST00000286364.3	+	6	632	c.597A>C	c.(595-597)ctA>ctC	p.L199L	RASA2_ENST00000452898.1_Silent_p.L199L			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	199	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						CAGTTTCTCTAGTGGGCCCTT	0.323000													8	105					0	0	1	0	0
ACBD5	91452	broad.mit.edu	37	10	27497271	27497271	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr10:27497271G>A	ENST00000396271.3	-	10	1434	c.1308C>T	c.(1306-1308)ctC>ctT	p.L436L	ACBD5_ENST00000375905.4_Silent_p.L401L|ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000375901.1_Silent_p.L327L|ACBD5_ENST00000375897.3_Silent_p.L259L|ACBD5_ENST00000375888.1_Silent_p.L445L	NM_001271512.1|NM_145698.3	NP_001258441.1|NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	445					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						TCTGCTCATTGAGGCTGCCTC	0.577000													13	63					0	0	1	0	0
GLDC	2731	broad.mit.edu	37	9	6592150	6592150	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:6592150G>A	ENST00000321612.6	-	11	1625	c.1475C>T	c.(1474-1476)tCa>tTa	p.S492L		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	492					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TACTGCAGATGACTCACAACC	0.398000													37	54					0	0	1	0	0
RXRG	6258	broad.mit.edu	37	1	165386384	165386384	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:165386384G>C	ENST00000359842.5	-	4	818	c.516C>G	c.(514-516)atC>atG	p.I172M	RXRG_ENST00000470566.1_5'UTR	NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	172					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GACACGTGTAGATGAGGTCCT	0.478000													8	58					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178928079	178928079	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:178928079G>A	ENST00000263967.3	+	8	1514	c.1357G>A	c.(1357-1359)Gaa>Aaa	p.E453K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	453	C2 PI3K-type.		E -> Q (in cancer; shows an increase in lipid kinase activity; may disrupt the interaction of the C2 PI3K-type domain with the iSH2 region of the p85 regulatory subunit).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E453K(11)|p.E453Q(5)|p.H450fs*9(1)|p.G451_L456>V(1)|p.P449_L455del(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCATGGATTAGAAGATTTGCT	0.348000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			26	98					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27683963	27683963	+	Silent	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:27683963C>G	ENST00000374040.3	-	22	3422	c.3162G>C	c.(3160-3162)ctG>ctC	p.L1054L	MAP3K6_ENST00000357582.2_Silent_p.L1062L|MAP3K6_ENST00000493901.1_Silent_p.L1062L			O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	1062					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GCCGTCCTTGCAGCGCCCGCA	0.672000											OREG0013282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	32					0	0	1	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26157254	26157254	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:26157254G>C	ENST00000304218.3	+	1	696	c.636G>C	c.(634-636)aaG>aaC	p.K212N		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	212					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						CCAAGCCAAAGAAGGCGGCAG	0.542000													4	24					0	0	1	0	0
SLC16A3	9123	broad.mit.edu	37	17	80196829	80196829	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:80196829C>T	ENST00000581287.1	+	4	3697	c.1375C>T	c.(1375-1377)Cac>Tac	p.H459Y	SLC16A3_ENST00000582743.1_Missense_Mutation_p.H459Y|SLC16A3_ENST00000392341.1_Missense_Mutation_p.H459Y|SLC16A3_ENST00000392339.1_Missense_Mutation_p.H459Y	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	459					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	GGAGGTGGTTCACACCCCGGA	0.587000													5	39					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44929487	44929487	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:44929487C>T	ENST00000377967.4	+	17	2628	c.2587C>T	c.(2587-2589)Cag>Tag	p.Q863*	KDM6A_ENST00000382899.4_Nonsense_Mutation_p.Q870*|KDM6A_ENST00000536777.1_Nonsense_Mutation_p.Q818*|KDM6A_ENST00000543216.1_Nonsense_Mutation_p.Q784*	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	863					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.Q863*(2)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						GGAAGAATCTCAGAGCCCCAT	0.463000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								5	19					0	0	1	0	0
SCAF11	9169	broad.mit.edu	37	12	46316822	46316822	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:46316822G>A	ENST00000465950.1	-	3	4286	c.3077C>T	c.(3076-3078)tCg>tTg	p.S1026L	SCAF11_ENST00000549162.1_Missense_Mutation_p.S1149L|SCAF11_ENST00000369367.3_Missense_Mutation_p.S1341L|SCAF11_ENST00000550629.1_5'UTR|SCAF11_ENST00000419565.2_Missense_Mutation_p.S1341L			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1341					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						ACTTGATGACGAAGTATTACC	0.468000													31	140					0	0	1	0	0
TNS4	84951	broad.mit.edu	37	17	38641231	38641231	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:38641231C>T	ENST00000254051.6	-	5	1475	c.1317G>A	c.(1315-1317)atG>atA	p.M439I		NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4	439					apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			TCACGAACTTCATGGTGGGCT	0.547000													9	31					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	23887621	23887621	+	Silent	SNP	G	G	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:23887621G>T	ENST00000546136.1	-	5	770	c.768C>A	c.(766-768)atC>atA	p.I256I	SOX5_ENST00000545921.1_Silent_p.I259I|SOX5_ENST00000541536.1_Silent_p.I256I|SOX5_ENST00000537393.1_Silent_p.I234I|SOX5_ENST00000309359.1_Silent_p.I256I|SOX5_ENST00000381381.2_Silent_p.I256I|SOX5_ENST00000451604.2_Silent_p.I269I			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	269					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						TTCTGACCTGGATCTGTTGCT	0.313000													3	51					1	1	1	1	0
PVRL3	25945	broad.mit.edu	37	3	110852616	110852616	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:110852616A>G	ENST00000485303.1	+	6	1479	c.1204A>G	c.(1204-1206)Att>Gtt	p.I402V	PVRL3_ENST00000493615.1_Intron|PVRL3_ENST00000319792.3_3'UTR	NM_001243286.1|NM_015480.2	NP_001230215.1|NP_056295.1	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3	402					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(3)	19						GGATGACACAATTGCCACGAT	0.448000													16	81					0	0	1	0	0
CLDN9	9080	broad.mit.edu	37	16	3063894	3063894	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:3063894C>T	ENST00000445369.2	+	1	1438	c.531C>T	c.(529-531)ggC>ggT	p.G177G		NM_020982.3	NP_066192.1	O95484	CLD9_HUMAN	claudin 9	177					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|lung(5)|prostate(2)	10						TTATGCTGGGCGGGGGGCTCC	0.721000													6	9					0	0	1	0	0
RPL29	6159	broad.mit.edu	37	3	52028115	52028115	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:52028115G>A	ENST00000466397.1	-	4	270	c.130C>T	c.(130-132)Cgc>Tgc	p.R44C	RPL29_ENST00000479017.1_Missense_Mutation_p.R44C|RPL29_ENST00000495383.1_Missense_Mutation_p.R44C|RPL29_ENST00000475248.1_Missense_Mutation_p.R44C|RPL29_ENST00000294189.6_Missense_Mutation_p.R44C			P47914	RL29_HUMAN	ribosomal protein L29	44					embryo implantation|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|protein binding|RNA binding|structural constituent of ribosome			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TTGGCAAAGCGCATGTTCCTC	0.552000													3	27					0	0	1	0	0
HNRNPA1	3178	broad.mit.edu	37	12	54675244	54675244	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:54675244G>A	ENST00000546500.1	+	2	705	c.90G>A	c.(88-90)ctG>ctA	p.L30L	RP11-968A15.8_ENST00000553061.1_RNA|HNRNPA1_ENST00000547276.1_Silent_p.L30L|HNRNPA1_ENST00000340913.6_Silent_p.L30L|HNRNPA1_ENST00000330752.8_Silent_p.L30L			P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	30	Globular A domain.|RRM 1.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20						ATGAGAGCCTGAGGAGCCATT	0.502000													13	39					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123111188	123111188	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr4:123111188G>A	ENST00000264501.4	+	10	1228	c.855G>A	c.(853-855)gtG>gtA	p.V285V	KIAA1109_ENST00000455637.1_Silent_p.V285V|KIAA1109_ENST00000388738.3_Silent_p.V285V			Q2LD37	K1109_HUMAN	KIAA1109	285					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GTTTTGTGGTGATGCAGTCAA	0.388000													3	55					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505849	195505849	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:195505849G>A	ENST00000463781.3	-	2	13061	c.12602C>T	c.(12601-12603)gCa>gTa	p.A4201V	MUC4_ENST00000475231.1_Missense_Mutation_p.A4201V|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	964					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACCTGTGGATGCTGAGGAAGT	0.592000													3	3					0	0	1	0	0
SETDB1	9869	broad.mit.edu	37	1	150900269	150900269	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:150900269C>T	ENST00000271640.5	+	2	269	c.79C>T	c.(79-81)Cag>Tag	p.Q27*	SETDB1_ENST00000459773.1_3'UTR|SETDB1_ENST00000368963.1_Nonsense_Mutation_p.Q27*|SETDB1_ENST00000368962.2_Nonsense_Mutation_p.Q27*|SETDB1_ENST00000368969.4_Nonsense_Mutation_p.Q27*	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	27					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGAGCTGCAACAGGCAGTGGT	0.493000													7	62					0	0	1	0	0
CLDN6	9074	broad.mit.edu	37	16	3065984	3065984	+	Silent	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:3065984C>G	ENST00000396925.1	-	3	467	c.39G>C	c.(37-39)ctG>ctC	p.L13L	CLDN6_ENST00000572154.1_Silent_p.L13L|CLDN6_ENST00000328796.4_Silent_p.L13L			P56747	CLD6_HUMAN	claudin 6	13					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity	p.L13L(1)		kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	10						CCAGCAGTGTCAGGACGACTC	0.607000													6	16					0	0	1	0	0
APOL5	80831	broad.mit.edu	37	22	36122361	36122361	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr22:36122361G>A	ENST00000249044.2	+	3	246	c.246G>A	c.(244-246)ctG>ctA	p.L82L		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5	82					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|skin(2)|urinary_tract(1)	19						TTGAAGAGCTGATGCGATGTG	0.418000													6	38					0	0	1	0	0
WIF1	11197	broad.mit.edu	37	12	65461483	65461483	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:65461483C>T	ENST00000286574.4	-	5	1000	c.626G>A	c.(625-627)tGt>tAt	p.C209Y		NM_007191.4	NP_009122.2	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1	209	EGF-like 1.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			cervix(1)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	21			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		ACCTTTCTCACAGTGAGGTCC	0.512000			T	HMGA2	pleomorphic salivary gland adenoma								5	35					0	0	1	0	0
RPL4	6124	broad.mit.edu	37	15	66794206	66794206	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr15:66794206C>T	ENST00000307961.6	-	5	558	c.466G>A	c.(466-468)Gat>Aat	p.D156N	RPL4_ENST00000568588.1_Missense_Mutation_p.D62N	NM_000968.3	NP_000959.2	P36578	RL4_HUMAN	ribosomal protein L4	156					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|stomach(1)|urinary_tract(1)	17						TCAACTTTATCTTCAACTACC	0.368000													4	37					0	0	1	0	0
ZNF277	11179	broad.mit.edu	37	7	111846782	111846782	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:111846782C>A	ENST00000421043.1	+	1	31	c.11C>A	c.(10-12)tCc>tAc	p.S4Y	ZNF277_ENST00000450657.1_Missense_Mutation_p.S4Y|ZNF277_ENST00000361822.3_Missense_Mutation_p.S4Y			Q9NRM2	ZN277_HUMAN	zinc finger protein 277	4						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	15						ATGGCTGCTTCCAAGACCCAG	0.647000													6	11					0.00198382	0.00203162	1	1	0
HARS	3035	broad.mit.edu	37	5	140057555	140057555	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:140057555C>G	ENST00000504366.1	-	5	2180	c.361G>C	c.(361-363)Gag>Cag	p.E121Q	HARS_ENST00000448240.1_Missense_Mutation_p.E28Q|HARS_ENST00000438307.2_Missense_Mutation_p.E150Q|HARS_ENST00000457527.2_Missense_Mutation_p.E170Q|HARS_ENST00000504156.1_Missense_Mutation_p.E190Q|HARS_ENST00000307633.3_Missense_Mutation_p.E130Q|HARS_ENST00000431330.2_Missense_Mutation_p.E76Q|HARS_ENST00000415192.2_Missense_Mutation_p.E116Q			P12081	SYHC_HUMAN	histidyl-tRNA synthetase	190					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	TTCAGGCACTCTGCATCAGGG	0.537000													6	21					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18859157	18859157	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:18859157T>C	ENST00000446231.2	-	37	6234	c.5822A>G	c.(5821-5823)aAc>aGc	p.N1941S	SMG1_ENST00000389467.3_Missense_Mutation_p.N1941S			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	1941	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CATGGTGGGGTTTGCAGAGGA	0.353000													14	62					0	0	1	0	0
B3GNT2	10678	broad.mit.edu	37	2	62450252	62450252	+	Silent	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:62450252C>G	ENST00000301998.4	+	2	1149	c.897C>G	c.(895-897)ctC>ctG	p.L299L	B3GNT2_ENST00000405767.1_Silent_p.L299L	NM_006577.5	NP_006568.2	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	299						Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)	18	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			ACTCTGGCCTCTACCCACCCT	0.527000													6	71					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51661656	51661656	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:51661656C>T	ENST00000409535.2	+	3	352	c.227C>T	c.(226-228)tCa>tTa	p.S76L		NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)							nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TCAACTACCTCATCTCAGTCT	0.567000													3	5					0	0	1	0	0
MTMR9	66036	broad.mit.edu	37	8	11162471	11162471	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr8:11162471G>A	ENST00000221086.3	+	4	1012	c.539G>A	c.(538-540)cGa>cAa	p.R180Q	MTMR9_ENST00000526292.1_Missense_Mutation_p.R95Q	NM_015458.3	NP_056273.2	Q96QG7	MTMR9_HUMAN	myotubularin related protein 9	180	Myotubularin phosphatase.					cytoplasm	phosphatase activity|protein binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(2)	16			STAD - Stomach adenocarcinoma(15;0.215)	COAD - Colon adenocarcinoma(149;0.0678)		GCTACATTTCGACATGGAGGG	0.458000													5	77					0	0	1	0	0
CCDC89	220388	broad.mit.edu	37	11	85396147	85396147	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:85396147C>T	ENST00000316398.3	-	1	1173	c.1027G>A	c.(1027-1029)Gaa>Aaa	p.E343K		NM_152723.1	NP_689936.1	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	343						cytoplasm|nucleus				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	15		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				AGCCTGAGTTCATCGTAGGCC	0.522000													12	40					0	0	1	0	0
FGL1	2267	broad.mit.edu	37	8	17726465	17726465	+	Missense_Mutation	SNP	C	C	T	rs147845891		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr8:17726465C>T	ENST00000398056.2	-	8	1366	c.551G>A	c.(550-552)cGt>cAt	p.R184H	FGL1_ENST00000398054.1_Missense_Mutation_p.R184H|FGL1_ENST00000381841.2_Missense_Mutation_p.R184H|FGL1_ENST00000427924.1_Missense_Mutation_p.R184H|FGL1_ENST00000381840.2_Missense_Mutation_p.R184H|FGL1_ENST00000522444.1_Missense_Mutation_p.R184H|FGL1_ENST00000518650.1_Missense_Mutation_p.R184H			Q08830	FGL1_HUMAN	fibrinogen-like 1	184	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)	13				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		TTGTGCATAACGGCTATTTTT	0.289000													4	62					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	86115927	86115927	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:86115927C>T	ENST00000383699.3	+	10	1836	c.1209C>T	c.(1207-1209)ttC>ttT	p.F403F	CADM2_ENST00000405615.2_Silent_p.F436F|CADM2_ENST00000407528.2_Silent_p.F434F	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	434					adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		AAGAGTATTTCATTTAAGATG	0.413000													12	47					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48586058	48586058	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:48586058C>T	ENST00000323776.5	+	1	314	c.152C>T	c.(151-153)tCc>tTc	p.S51F	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.S14F|MYCBPAP_ENST00000419930.1_Missense_Mutation_p.S51F	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	14					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			AAGAAGGATTCCCGCCTCAGA	0.617000													6	30					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432631	73432631	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:73432631C>T	ENST00000263666.4	-	10	3200	c.3086G>A	c.(3085-3087)aGg>aAg	p.R1029K	PDZRN3_ENST00000466780.1_Missense_Mutation_p.R686K|PDZRN3_ENST00000462146.2_Missense_Mutation_p.R686K|PDZRN3_ENST00000535920.1_Missense_Mutation_p.R751K|PDZRN3_ENST00000479530.1_Missense_Mutation_p.R746K	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	1029							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TTTCTTATTCCTCTTCTTCAT	0.458000													32	106					0	0	1	0	0
GORAB	92344	broad.mit.edu	37	1	170508626	170508626	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:170508626G>A	ENST00000367763.3	+	2	432	c.412G>A	c.(412-414)Gag>Aag	p.E138K	GORAB_ENST00000465717.1_3'UTR|GORAB_ENST00000367762.1_Missense_Mutation_p.E138K	NM_152281.2	NP_689494.2	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting	138						Golgi apparatus|nucleus				endometrium(2)|large_intestine(3)|liver(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	17						ACTGGGACTTGAGAATTCCCA	0.438000													5	45					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168838887	168838887	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:168838887G>A	ENST00000464456.1	-	6	1725	c.525C>T	c.(523-525)ctC>ctT	p.L175L	MECOM_ENST00000392736.3_Silent_p.L175L|MECOM_ENST00000494292.1_Silent_p.L363L|MECOM_ENST00000472280.1_Silent_p.L176L|MECOM_ENST00000460814.1_Silent_p.L175L|MECOM_ENST00000468789.1_Silent_p.L175L|MECOM_ENST00000264674.3_Silent_p.L240L|MECOM_ENST00000433243.2_Silent_p.L176L	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TGTGTTGTTTGAGGCCCGACG	0.552000													10	24					0	0	1	0	0
CTNND1	1500	broad.mit.edu	37	11	57575892	57575892	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:57575892C>T	ENST00000524630.1	+	13	2617	c.2104C>T	c.(2104-2106)Caa>Taa	p.Q702*	CTNND1_ENST00000361391.6_Nonsense_Mutation_p.Q702*|CTNND1_ENST00000527467.1_Nonsense_Mutation_p.Q385*|CTNND1_ENST00000526938.1_Nonsense_Mutation_p.Q708*|CTNND1_ENST00000529873.1_Nonsense_Mutation_p.Q648*|CTNND1_ENST00000361332.4_Nonsense_Mutation_p.Q702*|CTNND1_ENST00000426142.2_Nonsense_Mutation_p.Q601*|CTNND1_ENST00000534579.1_Nonsense_Mutation_p.Q648*|CTNND1_ENST00000530748.1_Nonsense_Mutation_p.Q654*|CTNND1_ENST00000528621.1_Nonsense_Mutation_p.Q648*|CTNND1_ENST00000528232.1_Nonsense_Mutation_p.Q607*|CTNND1_ENST00000532844.1_Nonsense_Mutation_p.Q654*|CTNND1_ENST00000358694.6_Nonsense_Mutation_p.Q702*|CTNND1_ENST00000529919.1_Nonsense_Mutation_p.Q708*|CTNND1_ENST00000360682.6_Nonsense_Mutation_p.Q708*|CTNND1_ENST00000415361.2_Nonsense_Mutation_p.Q607*|CTNND1_ENST00000532463.1_Nonsense_Mutation_p.Q601*|CTNND1_ENST00000525902.1_Nonsense_Mutation_p.Q385*|CTNND1_ENST00000399050.4_Nonsense_Mutation_p.Q708*|CTNND1_ENST00000399039.4_Nonsense_Mutation_p.Q708*|CTNND1_ENST00000526772.1_Nonsense_Mutation_p.Q379*|CTNND1_ENST00000428599.2_Nonsense_Mutation_p.Q702*|CTNND1_ENST00000529986.1_Nonsense_Mutation_p.Q601*|CTNND1_ENST00000532245.1_Nonsense_Mutation_p.Q601*|CTNND1_ENST00000532787.1_Nonsense_Mutation_p.Q601*|CTNND1_ENST00000361796.4_Nonsense_Mutation_p.Q702*|CTNND1_ENST00000526357.1_Nonsense_Mutation_p.Q648*|CTNND1_ENST00000531014.1_Nonsense_Mutation_p.Q379*|CTNND1_ENST00000529526.1_Nonsense_Mutation_p.Q648*|CTNND1_ENST00000533667.1_Nonsense_Mutation_p.Q379*|CTNND1_ENST00000532649.1_Nonsense_Mutation_p.Q648*|CTNND1_ENST00000530094.1_Nonsense_Mutation_p.Q601*			O60716	CTND1_HUMAN	catenin (cadherin-associated protein), delta 1	708					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(5)|endometrium(8)|kidney(4)|large_intestine(7)|liver(2)|lung(16)|ovary(1)|upper_aerodigestive_tract(2)	45		all_epithelial(135;0.155)				TGCTCTGCGTCAAGAGAAGGC	0.463000													13	52					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118758404	118758404	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:118758404A>G	ENST00000376300.2	-	4	493	c.356T>C	c.(355-357)gTt>gCt	p.V119A	CCDC93_ENST00000319432.5_Missense_Mutation_p.V119A|AC009303.1_ENST00000588042.1_RNA|AC009303.1_ENST00000590516.1_RNA	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	119										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						CACCTGAACAACAGGAAATAT	0.498000													3	35					0	0	1	0	0
PRPF4	9128	broad.mit.edu	37	9	116053819	116053819	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:116053819C>T	ENST00000374199.4	+	14	1846	c.1445C>T	c.(1444-1446)tCc>tTc	p.S482F	PRPF4_ENST00000374198.4_Missense_Mutation_p.S483F			O43172	PRP4_HUMAN	pre-mRNA processing factor 4	483						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	23						CCAGGCTGGTCCCCGCTGAAG	0.522000													25	24					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49652821	49652821	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:49652821C>T	ENST00000334186.4	+	28	3721	c.3372C>T	c.(3370-3372)ttC>ttT	p.F1124F	PPFIA3_ENST00000602351.1_Silent_p.F1115F	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	1124						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CCAAGTCTTTCAGCCGCTCCC	0.622000													3	10					0	0	1	0	0
C16orf11	146325	broad.mit.edu	37	16	615070	615070	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:615070G>A	ENST00000409413.3	+	3	1758	c.1479G>A	c.(1477-1479)ttG>ttA	p.L493L		NM_145270.2	NP_660313.1	P0CG20	CP011_HUMAN	chromosome 16 open reading frame 11	493										central_nervous_system(1)|endometrium(1)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10						GTCCCGTGTTGACCGGGGGCA	0.721000													5	12					0	0	1	0	0
TAF5L	27097	broad.mit.edu	37	1	229730829	229730829	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:229730829C>T	ENST00000258281.2	-	5	1150	c.985G>A	c.(985-987)Gat>Aat	p.D329N	TAF5L_ENST00000366676.1_Missense_Mutation_p.D329N	NM_014409.3	NP_055224.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	329					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				CCTGCATTATCATCCTCATCA	0.507000													3	27					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1807889	1807889	+	Missense_Mutation	SNP	A	A	G	rs78311289		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr4:1807889A>G	ENST00000340107.4	+	14	2210	c.1954A>G	c.(1954-1956)Aag>Gag	p.K652E	FGFR3_ENST00000352904.1_Missense_Mutation_p.K538E|FGFR3_ENST00000440486.2_Missense_Mutation_p.K650E|FGFR3_ENST00000412135.2_Missense_Mutation_p.K538E|FGFR3_ENST00000481110.2_Missense_Mutation_p.K651E|FGFR3_ENST00000260795.2_Missense_Mutation_p.K650E	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	650	Protein kinase.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.K650E(46)|p.K650Q(5)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CTACTACAAGAAGACGACCAA	0.667000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				6	6					0	0	1	0	0
ITPKC	80271	broad.mit.edu	37	19	41235171	41235171	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:41235171C>G	ENST00000263370.2	+	3	1353	c.1320C>G	c.(1318-1320)agC>agG	p.S440R		NM_025194.2	NP_079470.1	Q96DU7	IP3KC_HUMAN	inositol-trisphosphate 3-kinase C	440						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	14			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			AGCAGCGCAGCCTGGAGCAGC	0.537000													7	7					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32640936	32640936	+	Silent	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:32640936C>G	ENST00000421745.2	+	10	2711	c.2577C>G	c.(2575-2577)ctC>ctG	p.L859L		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	859					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TTACCTCGCTCATTTTGCTTC	0.388000													4	24					0	0	1	0	0
TXLNB	167838	broad.mit.edu	37	6	139564325	139564325	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:139564325C>T	ENST00000358430.3	-	10	1625	c.1393G>A	c.(1393-1395)Gaa>Aaa	p.E465K	RP1-225E12.3_ENST00000585874.1_RNA	NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	465						cytoplasm				breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TCATCCTTTTCAGATATTTCT	0.448000													14	87					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155385707	155385707	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:155385707C>T	ENST00000368346.3	-	6	6475	c.5836G>A	c.(5836-5838)Gaa>Aaa	p.E1946K	ASH1L_ENST00000392403.3_Missense_Mutation_p.E1946K			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1946					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			ACTGGTGCTTCATTAAAGCTA	0.338000													9	53					0	0	1	0	0
ECHS1	1892	broad.mit.edu	37	10	135184203	135184203	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr10:135184203C>T	ENST00000368547.3	-	2	502	c.147G>A	c.(145-147)ttG>ttA	p.L49L		NM_004092.3	NP_004083.3	P30084	ECHM_HUMAN	enoyl CoA hydratase, short chain, 1, mitochondrial	49					fatty acid beta-oxidation	mitochondrial matrix	enoyl-CoA hydratase activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|skin(1)	10		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;1.62e-06)|OV - Ovarian serous cystadenocarcinoma(35;5.75e-06)|Epithelial(32;7.58e-06)		TCAGTTGGATCAACCCCACGG	0.527000													4	15					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168289964	168289964	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:168289964G>A	ENST00000366806.2	+	7	1109	c.967G>A	c.(967-969)Gag>Aag	p.E323K	MLLT4_ENST00000351017.4_Missense_Mutation_p.E323K|MLLT4_ENST00000400822.3_Missense_Mutation_p.E322K|MLLT4_ENST00000392108.3_Missense_Mutation_p.E323K|MLLT4_ENST00000447894.2_Missense_Mutation_p.E323K|MLLT4_ENST00000392112.1_Missense_Mutation_p.E322K|MLLT4_ENST00000344191.4_Missense_Mutation_p.E323K			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	323	Ras-associating 2.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TGATGATGATGAGTGTCCTTT	0.358000			T	MLL	AL								29	89					0	0	1	0	0
ZNF718	255403	broad.mit.edu	37	4	155048	155048	+	RNA	SNP	A	A	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr4:155048A>T	ENST00000510175.1	+	0	483							Q3SXZ3	ZN718_HUMAN	zinc finger protein 718						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		AACACAAAAGAATTCATACTG	0.363000													4	33					0	0	1	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204380339	204380339	+	Silent	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:204380339G>C	ENST00000367188.4	-	1	580	c.201C>G	c.(199-201)ctC>ctG	p.L67L	RP11-739N20.2_ENST00000443515.1_RNA	NM_032833.3	NP_116222.3	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	67					regulation of translation					breast(3)|cervix(1)|kidney(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(2)|skin(1)|urinary_tract(3)	34	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			GGAGCTGGGAGAGCAGTTTCG	0.567000													7	56					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121882	38121882	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr22:38121882C>T	ENST00000406386.3	+	7	3574	c.3319C>T	c.(3319-3321)Cag>Tag	p.Q1107*		NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1107					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CGAGCCCCTTCAGCTCCCTGC	0.642000													12	58					0	0	1	0	0
EDC4	23644	broad.mit.edu	37	16	67914796	67914796	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:67914796G>A	ENST00000358933.5	+	18	2673	c.2434G>A	c.(2434-2436)Gag>Aag	p.E812K		NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	812					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CTCCCTCCTGGAGGCAGCCTT	0.662000													15	47					0	0	1	0	0
SEC31B	25956	broad.mit.edu	37	10	102269090	102269090	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr10:102269090C>G	ENST00000370345.3	-	4	479	c.382G>C	c.(382-384)Gac>Cac	p.D128H	SEC31B_ENST00000370329.5_Missense_Mutation_p.D128H|NDUFB8_ENST00000531258.1_Intron|SEC31B_ENST00000451524.1_Missense_Mutation_p.D128H|NDUFB8_ENST00000557395.1_Intron|SEC31B_ENST00000535773.1_Intron	NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	128					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		GGATTCAAGTCGAGGGCTCTG	0.498000											OREG0020441	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	148					0	0	1	0	0
PNLDC1	154197	broad.mit.edu	37	6	160237056	160237056	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:160237056G>A	ENST00000610273.1	+	13	1189	c.1018G>A	c.(1018-1020)Gag>Aag	p.E340K	PNLDC1_ENST00000392167.3_Missense_Mutation_p.E351K	NM_001271862.1|NM_173516.1	NP_001258791.1|NP_775787.1	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain containing 1							integral to membrane|nucleus	nucleic acid binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	31		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		GAGCAGGTGTGAGAAATATGG	0.463000													5	73					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	192994603	192994603	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:192994603G>A	ENST00000342358.4	-	29	3449	c.3332C>T	c.(3331-3333)aCa>aTa	p.T1111I	ATP13A5_ENST00000495496.1_5'UTR	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	1111					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CCTCCACGATGTTATGGTTGG	0.308000													9	37					0	0	1	0	0
OCEL1	79629	broad.mit.edu	37	19	17339731	17339731	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:17339731C>T	ENST00000215061.4	+	6	836	c.792C>T	c.(790-792)ttC>ttT	p.F264F	OCEL1_ENST00000601529.1_3'UTR|OCEL1_ENST00000597836.1_Silent_p.F208F	NM_024578.1	NP_078854.1	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	264										central_nervous_system(2)|endometrium(2)|kidney(1)|lung(2)	7						CCGTGTACTTCTAAGTGCCCC	0.547000													5	25					0	0	1	0	0
ZNF383	163087	broad.mit.edu	37	19	37734533	37734533	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:37734533C>T	ENST00000589413.1	+	8	1978	c.1395C>T	c.(1393-1395)ctC>ctT	p.L465L	ZNF383_ENST00000352998.3_Silent_p.L465L|ZNF383_ENST00000590503.1_Silent_p.L465L			Q8NA42	ZN383_HUMAN	zinc finger protein 383	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)	15			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GCTCGGATCTCATTCGTCATC	0.368000													8	59					0	0	1	0	0
KDM3A	55818	broad.mit.edu	37	2	86693911	86693911	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:86693911C>T	ENST00000409556.1	+	11	1789	c.1424C>T	c.(1423-1425)tCa>tTa	p.S475L	KDM3A_ENST00000312912.5_Missense_Mutation_p.S475L|KDM3A_ENST00000542128.1_Missense_Mutation_p.S423L|KDM3A_ENST00000409064.1_Missense_Mutation_p.S475L|KDM3A_ENST00000485171.1_Intron			Q9Y4C1	KDM3A_HUMAN	lysine (K)-specific demethylase 3A	475					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(3)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(3)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	47						GTAGAACCTTCAGCTTTAGCT	0.393000													13	49					0	0	1	0	0
MYOG	4656	broad.mit.edu	37	1	203053814	203053814	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:203053814C>T	ENST00000241651.4	-	2	588	c.514G>A	c.(514-516)Gag>Aag	p.E172K		NM_002479.5	NP_002470.2	P15173	MYOG_HUMAN	myogenin (myogenic factor 4)	172					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|urinary_tract(1)	12						CTGCCCCACTCTGGACTGCAG	0.612000													4	5					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	214878727	214878727	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:214878727G>C	ENST00000331683.5	+	13	1548	c.1453G>C	c.(1453-1455)Gag>Cag	p.E485Q	SPAG16_ENST00000374309.3_Missense_Mutation_p.E391Q	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	485					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		GAACAGCATTGAGTTTTTTCC	0.363000													11	65					0	0	1	0	0
PIWIL4	143689	broad.mit.edu	37	11	94301962	94301962	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:94301962A>G	ENST00000299001.6	+	2	365	c.154A>G	c.(154-156)Atc>Gtc	p.I52V	RP11-867G2.8_ENST00000536540.1_RNA|RP11-867G2.8_ENST00000537874.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	52					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AACAAGCAGGATCTCAACCAA	0.448000													4	40					0	0	1	0	0
ZNF609	23060	broad.mit.edu	37	15	64791901	64791901	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr15:64791901A>C	ENST00000326648.3	+	1	411	c.283A>C	c.(283-285)Agt>Cgt	p.S95R	ZNF609_ENST00000416172.1_Missense_Mutation_p.S95R	NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	95						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AAGGAGTAAGAGTGGCAAAGA	0.532000													9	25					0	0	1	0	0
EXD3	54932	broad.mit.edu	37	9	140267374	140267374	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:140267374C>G	ENST00000340951.4	-	5	640	c.445G>C	c.(445-447)Gag>Cag	p.E149Q	EXD3_ENST00000479452.1_Missense_Mutation_p.E149Q|EXD3_ENST00000342129.4_5'UTR|EXD3_ENST00000475006.1_5'UTR	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	149					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						AACCTGCCCTCGTGGTGGAGG	0.687000													3	40					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66461183	66461183	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:66461183C>T	ENST00000404260.3	+	29	6493	c.6185C>T	c.(6184-6186)tCc>tTc	p.S2062F	MAST4_ENST00000405643.1_Missense_Mutation_p.S1880F|MAST4_ENST00000403625.2_Missense_Mutation_p.S2059F|MAST4_ENST00000261569.7_Missense_Mutation_p.S1865F|MAST4_ENST00000403666.1_Missense_Mutation_p.S1870F			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	2062						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGAGACAACTCCTCTCTGCAC	0.617000													3	29					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113678963	113678963	+	Silent	SNP	C	C	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr13:113678963C>A	ENST00000397030.1	+	3	305	c.268C>A	c.(268-270)Cgg>Agg	p.R90R	MCF2L_ENST00000375604.2_Silent_p.R114R|MCF2L_ENST00000375601.3_Silent_p.R61R|MCF2L_ENST00000397024.1_Silent_p.R55R|MCF2L_ENST00000375597.4_Silent_p.R55R|MCF2L_ENST00000423482.2_Silent_p.R55R|MCF2L_ENST00000421756.1_Silent_p.R61R|MCF2L_ENST00000434480.2_Silent_p.R63R|MCF2L_ENST00000535094.2_Silent_p.R57R|MCF2L_ENST00000375608.3_Silent_p.R87R|MCF2L_ENST00000442652.2_Silent_p.R87R			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	87	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CCCAGGTGGGCGGGGGCAGGA	0.612000													5	31					3.59834e-05	3.74139e-05	1	1	0
ARSD	414	broad.mit.edu	37	X	2827914	2827914	+	Silent	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:2827914C>G	ENST00000381154.1	-	8	1317	c.1242G>C	c.(1240-1242)ctG>ctC	p.L414L		NM_001669.3	NP_001660.2	P51689	ARSD_HUMAN	arylsulfatase D	414						lysosome	arylsulfatase activity|metal ion binding			large_intestine(3)|lung(3)	6		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACACGTCCATCAGGCTCGTGG	0.622000													7	31					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201981084	201981084	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:201981084G>A	ENST00000359651.3	+	2	3355		c.e2-1		ELF3_ENST00000495848.1_Splice_Site|ELF3_ENST00000367283.3_Splice_Site|RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367284.5_Splice_Site			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )						epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						GGCCCTTGCAGAGAAGGCCAG	0.537000													6	68					0	0	1	0	0
VRK2	7444	broad.mit.edu	37	2	58311247	58311247	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:58311247A>T	ENST00000435505.2	+	6	905	c.160A>T	c.(160-162)Aaa>Taa	p.K54*	VRK2_ENST00000412104.2_Nonsense_Mutation_p.K54*|VRK2_ENST00000417641.2_Nonsense_Mutation_p.K54*|VRK2_ENST00000440705.2_Nonsense_Mutation_p.K31*|VRK2_ENST00000340157.4_Nonsense_Mutation_p.K54*			Q86Y07	VRK2_HUMAN	vaccinia related kinase 2	54	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	24						TAAACCAGAGAAAGATGCAAG	0.328000													6	62					0	0	1	0	0
FAM221A	340277	broad.mit.edu	37	7	23731102	23731102	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:23731102G>A	ENST00000344962.4	+	4	613	c.524G>A	c.(523-525)aGa>aAa	p.R175K	FAM221A_ENST00000409653.1_Missense_Mutation_p.R117K|FAM221A_ENST00000409994.3_Missense_Mutation_p.R117K|FAM221A_ENST00000409192.3_Missense_Mutation_p.R175K	NM_199136.3	NP_954587.2	A4D161	CG046_HUMAN	family with sequence similarity 221, member A	175																	AAGCAAGAAAGATTGGCTCAG	0.488000													20	59					0	0	1	0	0
TRAV6	6956	broad.mit.edu	37	14	22237207	22237207	+	RNA	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:22237207A>G	ENST00000390428.3	+	0	291																											AATGAGAAAGAAAAAAGGAAA	0.438000													8	50					0	0	1	0	0
GPATCH3	63906	broad.mit.edu	37	1	27219934	27219934	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:27219934C>T	ENST00000361720.5	-	4	1080	c.1057G>A	c.(1057-1059)Gat>Aat	p.D353N		NM_022078.2	NP_071361.2	Q96I76	GPTC3_HUMAN	G patch domain containing 3	353						intracellular	nucleic acid binding			endometrium(2)|large_intestine(1)|lung(11)|skin(1)	15		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		GTCTGTTCATCAAAATCTGTA	0.418000													14	171					0	0	1	0	0
SPRR3	6707	broad.mit.edu	37	1	152975642	152975642	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:152975642G>T	ENST00000331860.3	+	3	296	c.146G>T	c.(145-147)gGa>gTa	p.G49V	SPRR3_ENST00000542696.1_Missense_Mutation_p.G49V|SPRR3_ENST00000295367.4_Missense_Mutation_p.G49V	NM_005416.2	NP_005407.1	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	49	14 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	11	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCACAACCTGGAAACACAAAG	0.547000													3	20					0.004672	0.00477021	1	1	0
LYPD3	27076	broad.mit.edu	37	19	43967856	43967856	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:43967856C>A	ENST00000244333.3	-	3	365	c.277G>T	c.(277-279)Ggc>Tgc	p.G93C		NM_014400.2	NP_055215.2	O95274	LYPD3_HUMAN	LY6/PLAUR domain containing 3	93	UPAR/Ly6 1.					anchored to plasma membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|upper_aerodigestive_tract(2)	11		Prostate(69;0.0153)				AGATCCAGGCCGCGGTCATTC	0.642000													3	19					1	1	1	1	0
MB21D2	151963	broad.mit.edu	37	3	192516176	192516176	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:192516176C>T	ENST00000392452.2	-	2	1795	c.1475G>A	c.(1474-1476)tGa>tAa	p.*492*		NM_178496.3	NP_848591.2	Q8IYB1	M21D2_HUMAN	Mab-21 domain containing 2	0										endometrium(3)|kidney(1)|large_intestine(4)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	31						AGCTAACACTCAGAAAAATTT	0.388000													13	58					0	0	1	0	0
GBP2	2634	broad.mit.edu	37	1	89579891	89579891	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:89579891C>T	ENST00000370466.3	-	7	1225	c.957G>A	c.(955-957)caG>caA	p.Q319Q	GBP2_ENST00000463660.1_5'UTR	NM_004120.3	NP_004111.2	P32456	GBP2_HUMAN	guanylate binding protein 2, interferon-inducible	319					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(1)	20		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		AGTTCTCTATCTGGGCCAAGG	0.577000													4	36					0	0	1	0	0
AMBRA1	55626	broad.mit.edu	37	11	46456527	46456527	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:46456527G>A	ENST00000458649.2	-	13	3111	c.2693C>T	c.(2692-2694)tCt>tTt	p.S898F	AMBRA1_ENST00000533727.1_Missense_Mutation_p.S779F|AMBRA1_ENST00000314845.3_Missense_Mutation_p.S808F|AMBRA1_ENST00000528950.1_Missense_Mutation_p.S869F|AMBRA1_ENST00000298834.3_Missense_Mutation_p.S838F|AMBRA1_ENST00000426438.1_Missense_Mutation_p.S869F|AMBRA1_ENST00000534300.1_Missense_Mutation_p.S838F			Q9C0C7	AMRA1_HUMAN	autophagy/beclin-1 regulator 1	898					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				NS(1)|breast(3)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	39				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		GCCATCTGCAGAAATGTCACA	0.517000													3	18					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96609733	96609733	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr10:96609733C>A	ENST00000371321.3	+	8	1291	c.1209C>A	c.(1207-1209)aaC>aaA	p.N403K	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	403					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	AATTTCCCAACCCAGAGATGT	0.383000													9	86					0.0477658	0.0483344	1	1	0
BEND2	139105	broad.mit.edu	37	X	18234766	18234766	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:18234766G>C	ENST00000380033.4	-	2	245	c.113C>G	c.(112-114)tCc>tGc	p.S38C	BEND2_ENST00000380030.3_Missense_Mutation_p.S38C	NM_153346.4	NP_699177.2	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	38										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(11)|liver(1)|lung(21)|ovary(3)|prostate(1)	49						GTCATTAGTGGAATTATCTGC	0.393000													11	37					0	0	1	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112778290	112778290	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:112778290G>A	ENST00000374530.3	+	7	733	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	PALM2-AKAP2_ENST00000302798.7_Missense_Mutation_p.E185K|AKAP2_ENST00000555236.1_Missense_Mutation_p.E185K|AKAP2_ENST00000510514.5_Missense_Mutation_p.E185K	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		0							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						GAACGCCACAGAAACATCCGG	0.473000													8	13					0	0	1	0	0
TNFAIP8	25816	broad.mit.edu	37	5	118728866	118728866	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:118728866C>T	ENST00000504771.2	+	2	2164	c.387C>T	c.(385-387)tcC>tcT	p.S129S	TNFAIP8_ENST00000503646.1_Silent_p.S129S|TNFAIP8_ENST00000415806.2_3'UTR|TNFAIP8_ENST00000274456.6_Silent_p.S119S|TNFAIP8_ENST00000504642.1_Silent_p.S131S|TNFAIP8_ENST00000513374.1_Silent_p.S141S	NM_014350.2	NP_055165.2	O95379	TFIP8_HUMAN	tumor necrosis factor, alpha-induced protein 8	129					anti-apoptosis|apoptosis|negative regulation of anti-apoptosis	cytoplasm	caspase inhibitor activity|protein binding			ovary(1)	1		all_cancers(142;0.0317)|Prostate(80;0.111)|Breast(839;0.231)		Epithelial(69;4.63e-83)|OV - Ovarian serous cystadenocarcinoma(64;1.39e-82)|all cancers(49;4.88e-75)|GBM - Glioblastoma multiforme(465;0.00338)|BRCA - Breast invasive adenocarcinoma(61;0.0148)|COAD - Colon adenocarcinoma(49;0.0829)		ATGTGTTATCCAGGCTGTTAA	0.418000													9	48					0	0	1	0	0
AP1M2	10053	broad.mit.edu	37	19	10692495	10692495	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:10692495G>A	ENST00000590923.1	-	4	410	c.327C>T	c.(325-327)atC>atT	p.I109I	AP1M2_ENST00000250244.6_Silent_p.I109I			Q9Y6Q5	AP1M2_HUMAN	adaptor-related protein complex 1, mu 2 subunit	109					cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			endometrium(4)|large_intestine(1)|lung(1)|ovary(2)|urinary_tract(1)	9			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			ACTCGTAGACGATGACAAAGT	0.567000													6	16					0	0	1	0	0
NUP88	4927	broad.mit.edu	37	17	5322721	5322721	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:5322721G>A	ENST00000573584.1	-	1	759	c.250C>T	c.(250-252)Cgg>Tgg	p.R84W		NM_002532.4	NP_002523.2	Q99567	NUP88_HUMAN	nucleoporin 88kDa	84					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			endometrium(4)|kidney(4)|large_intestine(4)|lung(3)	15						CTGGGGCCCCGAAGGCGAACG	0.637000													12	24					0	0	1	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140797678	140797678	+	Silent	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:140797678A>G	ENST00000398594.2	+	1	252	c.252A>G	c.(250-252)ttA>ttG	p.L84L	PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGGGACTTACTTGTGAAGG	0.498000													13	55					0	0	1	0	0
WDR43	23160	broad.mit.edu	37	2	29152518	29152518	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:29152518A>G	ENST00000407426.3	+	11	1435	c.1379A>G	c.(1378-1380)aAt>aGt	p.N460S		NM_015131.1	NP_055946.1	Q15061	WDR43_HUMAN	WD repeat domain 43	460						nucleolus				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	20	Acute lymphoblastic leukemia(172;0.155)					CTCCAGACGAATAGCTTTCCA	0.348000													4	25					0	0	1	0	0
ACAP2	23527	broad.mit.edu	37	3	195102686	195102686	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:195102686G>A	ENST00000326793.6	-	3	407	c.177C>T	c.(175-177)ttC>ttT	p.F59F		NM_012287.5	NP_036419.3	Q15057	ACAP2_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	59	BAR.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	27						TCCCATTCATGAACTGTTTAT	0.318000													20	51					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37356576	37356576	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:37356576C>G	ENST00000373091.3	-	2	253	c.237G>C	c.(235-237)ttG>ttC	p.L79F	GRIK3_ENST00000373093.4_Missense_Mutation_p.L79F	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	79					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGTCATAGGTCAAGGTTGTGT	0.542000													6	78					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43625175	43625175	+	Silent	SNP	G	G	A	rs141394008		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr22:43625175G>A	ENST00000360835.4	-	9	1113	c.987C>T	c.(985-987)ttC>ttT	p.F329F		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1		EGF-like 8; calcium-binding (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				AGGTCCGCTCGAAGGAGCACT	0.617000											OREG0026614	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	16					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47408940	47408940	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:47408940C>G	ENST00000398879.1	-	17	1669	c.1303G>C	c.(1303-1305)Gaa>Caa	p.E435Q	TNS3_ENST00000311160.9_Missense_Mutation_p.E435Q|TNS3_ENST00000355730.3_Intron			Q68CZ2	TENS3_HUMAN	tensin 3	435						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						CCAGGATCTTCCAGGCCAAAG	0.607000													5	33					0	0	1	0	0
FAM161B	145483	broad.mit.edu	37	14	74404787	74404787	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:74404787C>T	ENST00000286544.3	-	6	1816	c.1618G>A	c.(1618-1620)Gat>Aat	p.D540N	RP5-1021I20.5_ENST00000555916.1_RNA|FAM161B_ENST00000534936.1_Missense_Mutation_p.D477N	NM_152445.2	NP_689658.2			family with sequence similarity 161, member B											breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)	21						ATACTCTCATCTGCTTTGTTC	0.418000													30	121					0	0	1	0	0
NBPF3	84224	broad.mit.edu	37	1	21798217	21798217	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:21798217G>A	ENST00000318220.6	+	8	1482	c.434G>A	c.(433-435)cGa>cAa	p.R145Q	NBPF3_ENST00000342104.5_Missense_Mutation_p.R201Q|NBPF3_ENST00000454000.2_Missense_Mutation_p.R131Q|NBPF3_ENST00000318249.5_Missense_Mutation_p.R201Q			Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	201						cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	20		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CGGGACCTCCGAGAACAGCTG	0.602000													10	98					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37623551	37623551	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr21:37623551G>C	ENST00000399151.3	+	22	5175	c.5090G>C	c.(5089-5091)aGa>aCa	p.R1697T		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1697					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane		p.R1697T(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						GTGTGGAGCAGAAAGAAAGCC	0.418000													4	46					0	0	1	0	0
MRPL35	51318	broad.mit.edu	37	2	86437695	86437695	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:86437695C>T	ENST00000337109.4	+	4	505	c.471C>T	c.(469-471)ctC>ctT	p.L157L	MRPL35_ENST00000254644.8_Silent_p.L157L|MRPL35_ENST00000409180.1_Silent_p.L157L|MRPL35_ENST00000605125.1_3'UTR	NM_016622.3	NP_057706.2	Q9NZE8	RM35_HUMAN	mitochondrial ribosomal protein L35	157					translation	mitochondrial ribosome	structural constituent of ribosome	p.L157L(1)		cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(4)|skin(1)|stomach(1)|urinary_tract(2)	14						AGAGTAAACTCTTAGATAAAA	0.388000													10	33					0	0	1	0	0
RIMKLA	284716	broad.mit.edu	37	1	42880478	42880478	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:42880478G>C	ENST00000431473.3	+	5	1138	c.1009G>C	c.(1009-1011)Gag>Cag	p.E337Q		NM_173642.3	NP_775913.2	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family member A	337					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						GGGAGTTGCAGAGAGCGTCTA	0.562000													13	28					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101777720	101777720	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:101777720T>G	ENST00000375001.3	+	10	1798	c.1375T>G	c.(1375-1377)Tta>Gta	p.L459V		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	459	4 X tandem repeats.|Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				TGAAGACAGTTTAACAACAGC	0.577000													6	25					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	26101081	26101081	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:26101081T>C	ENST00000435504.4	-	1	304	c.11A>G	c.(10-12)aAg>aGg	p.K4R	ASXL2_ENST00000336112.4_5'UTR|ASXL2_ENST00000272341.4_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTACGTCCCTTTTCCCTCAT	0.667000													3	47					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13829755	13829755	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:13829755G>A	ENST00000265104.4	-	38	6412	c.6308C>T	c.(6307-6309)tCa>tTa	p.S2103L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2103	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CATGGCCACTGAGCGGAAATT	0.453000									Kartagener syndrome				13	67					0	0	1	0	0
ZNF92	168374	broad.mit.edu	37	7	64864592	64864592	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:64864592C>G	ENST00000328747.7	+	4	1764	c.1565C>G	c.(1564-1566)tCa>tGa	p.S522*	ZNF92_ENST00000450302.2_Nonsense_Mutation_p.S453*|ZNF92_ENST00000357512.2_Nonsense_Mutation_p.S490*|ZNF92_ENST00000431504.1_Nonsense_Mutation_p.S446*	NM_152626.2	NP_689839.1	Q03936	ZNF92_HUMAN	zinc finger protein 92	522						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				AACCAGTCCTCAAACCTTACT	0.348000													9	53					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23870046	23870046	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:23870046G>A	ENST00000405093.3	-	13	1352	c.1282C>T	c.(1282-1284)Ctg>Ttg	p.L428L	MYH6_ENST00000356287.3_Silent_p.L428L	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	428	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCCTTGGCCAGAGCCCCGATG	0.582000													7	34					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049681	107049681	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:107049681T>C	ENST00000409886.3	-	16	2353	c.2266A>G	c.(2266-2268)Aac>Gac	p.N756D	RGPD3_ENST00000304514.7_Missense_Mutation_p.N756D	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	756					intracellular transport		binding	p.N756D(6)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TCACTATAGTTTTCGAGTTCC	0.373000													4	396					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86960029	86960029	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:86960029A>G	ENST00000234701.3	+	12	2191	c.1840A>G	c.(1840-1842)Att>Gtt	p.I614V	CLCA1_ENST00000394711.1_Missense_Mutation_p.I614V			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	614					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		TTATGCAAATATTCGCCAAGG	0.493000													7	18					0	0	1	0	0
FAM91A1	157769	broad.mit.edu	37	8	124812070	124812070	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr8:124812070C>G	ENST00000334705.7	+	18	2000	c.1754C>G	c.(1753-1755)tCa>tGa	p.S585*	FAM91A1_ENST00000521166.1_Nonsense_Mutation_p.S585*	NM_144963.2	NP_659400	Q658Y4	F91A1_HUMAN	family with sequence similarity 91, member A1	585										breast(4)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			GTTCCTACCTCAAATGTGCTC	0.313000													27	93					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46279860	46279860	+	Silent	SNP	G	G	A	rs151060280	byFrequency	TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr20:46279860G>A	ENST00000372004.3	+	20	3990	c.3774G>A	c.(3772-3774)caG>caA	p.Q1258Q	NCOA3_ENST00000341724.6_Silent_p.Q1188Q|NCOA3_ENST00000371998.3_Silent_p.Q1262Q|NCOA3_ENST00000371997.3_Silent_p.Q1253Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1262	Acetyltransferase.|Poly-Gln.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding	p.Q1262Q(1)		breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcagcaacagc	0.567000													3	31					0	0	1	0	0
NBEAL1	65065	broad.mit.edu	37	2	204074025	204074025	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:204074025G>A	ENST00000449802.1	+	52	8011	c.7678G>A	c.(7678-7680)Gaa>Aaa	p.E2560K		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	2560							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CTCCAGCACTGAAGAAAAGAC	0.423000													7	69					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173901378	173901378	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:173901378G>A	ENST00000264111.6	+	29	2995	c.2808G>A	c.(2806-2808)ggG>ggA	p.G936G	RAPGEF4_ENST00000539331.1_Silent_p.G784G|RAPGEF4_ENST00000538974.1_Silent_p.G766G|RAPGEF4_ENST00000540783.1_Silent_p.G784G|RAPGEF4_ENST00000397087.3_Silent_p.G793G|RAPGEF4_ENST00000397081.3_Silent_p.G937G|RAPGEF4_ENST00000409036.1_Intron|RAPGEF4_ENST00000535187.1_Silent_p.G717G			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	937	Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CTCATGAGGGGAACAAGACGT	0.294000													4	45					0	0	1	0	0
SPAG9	9043	broad.mit.edu	37	17	49071168	49071168	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:49071168G>A	ENST00000262013.7	-	19	2563	c.2355C>T	c.(2353-2355)ttC>ttT	p.F785F	SPAG9_ENST00000510283.1_Silent_p.F628F|SPAG9_ENST00000505279.1_Silent_p.F775F|SPAG9_ENST00000357122.4_Silent_p.F771F	NM_001130528.2	NP_001124000.1	O60271	JIP4_HUMAN	sperm associated antigen 9	785					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			TGCAAACAGTGAAACTGTCTA	0.463000													8	37					0	0	1	0	0
CLPSL2	389383	broad.mit.edu	37	6	35745245	35745245	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:35745245G>A	ENST00000360454.2	+	2	98	c.94G>A	c.(94-96)Gac>Aac	p.D32N	CLPSL2_ENST00000403376.3_Missense_Mutation_p.D32N|CLPSL2_ENST00000481904.1_3'UTR			Q6UWE3	CF126_HUMAN	colipase-like 2	32					digestion|lipid catabolic process	extracellular region	enzyme activator activity										GAAAATCACAGACAGGTGCTT	0.587000													14	39					0	0	1	0	0
TMEM19	55266	broad.mit.edu	37	12	72091096	72091096	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:72091096G>A	ENST00000266673.5	+	4	1013	c.419G>A	c.(418-420)gGa>gAa	p.G140E	TMEM19_ENST00000549735.1_Missense_Mutation_p.G140E|RP11-293I14.2_ENST00000548802.1_3'UTR	NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	140						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		TTCTGTAATGGAGCTGTACCC	0.463000													29	87					0	0	1	0	0
FIGNL1	63979	broad.mit.edu	37	7	50513580	50513580	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:50513580G>A	ENST00000419119.1	-	2	2959	c.1406C>T	c.(1405-1407)tCc>tTc	p.S469F	FIGNL1_ENST00000433017.1_Missense_Mutation_p.S469F|FIGNL1_ENST00000395556.2_Missense_Mutation_p.S469F|FIGNL1_ENST00000356889.4_Missense_Mutation_p.S469F			Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	469					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	29	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				AGAAGTTAAGGATGAAGCAGA	0.443000													8	53					0	0	1	0	0
TMEM17	200728	broad.mit.edu	37	2	62733174	62733174	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:62733174C>T	ENST00000335390.5	-	1	302	c.91G>A	c.(91-93)Gag>Aag	p.E31K		NM_198276.2	NP_938017.2	Q86X19	TMM17_HUMAN	transmembrane protein 17	31						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	9	Lung NSC(7;0.0274)|all_lung(7;0.0568)		LUSC - Lung squamous cell carcinoma(7;1.31e-05)|Epithelial(17;0.169)			CCCGGACCCTCATTGGACTCT	0.637000													3	10					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20193903	20193903	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:20193903C>T	ENST00000263754.4	+	18	2840	c.2385C>T	c.(2383-2385)gtC>gtT	p.V795V		NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	795	Bromo.				cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						TACAGCGAGTCTTTACCAATT	0.383000													16	43					0	0	1	0	0
FAM46D	169966	broad.mit.edu	37	X	79698075	79698075	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:79698075C>T	ENST00000538312.1	+	5	371	c.37C>T	c.(37-39)Caa>Taa	p.Q13*	FAM46D_ENST00000308293.5_Nonsense_Mutation_p.Q13*	NM_001170574.1	NP_001164045.1	Q8NEK8	FA46D_HUMAN	family with sequence similarity 46, member D	13										kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23						CACTTGGGATCAAGTTATAAC	0.363000													5	31					0	0	1	0	0
BRCA1	672	broad.mit.edu	37	17	41244679	41244679	+	Missense_Mutation	SNP	G	G	C	rs80357961		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:41244679G>C	ENST00000309486.4	-	9	3008	c.1981C>G	c.(1981-1983)Cag>Gag	p.Q661E	BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000346315.3_Missense_Mutation_p.Q957E|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000491747.2_Intron|BRCA1_ENST00000357654.3_Missense_Mutation_p.Q957E|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000493795.1_Missense_Mutation_p.Q910E|BRCA1_ENST00000354071.3_Missense_Mutation_p.Q957E|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000471181.2_Missense_Mutation_p.Q957E|BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000591849.1_Intron	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	957					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCTCTGAACTGAGATGATAGA	0.393000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			21	133					0	0	1	0	0
SNRPA1	6627	broad.mit.edu	37	15	101827177	101827177	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr15:101827177C>T	ENST00000254193.6	-	5	467	c.395G>A	c.(394-396)aGa>aAa	p.R132K	SNRPA1_ENST00000560856.1_5'UTR	NM_003090.2	NP_003081.2	P09661	RU2A_HUMAN	small nuclear ribonucleoprotein polypeptide A'	132	LRRCT.					catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6	Lung NSC(78;0.00156)|all_lung(78;0.00195)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00113)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CACATACAATCTGTAATGCTT	0.373000													13	96					0	0	1	0	0
TFRC	7037	broad.mit.edu	37	3	195802106	195802106	+	Silent	SNP	G	G	A	rs41300443	byFrequency	TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:195802106G>A	ENST00000360110.4	-	3	331	c.162C>T	c.(160-162)gcC>gcT	p.A54A	TFRC_ENST00000392396.3_Silent_p.A54A|TFRC_ENST00000420415.1_Intron|TFRC_ENST00000540528.1_Intron|TFRC_ENST00000535031.1_Intron	NM_001128148.1	NP_001121620.1	P02786	TFR1_HUMAN	transferrin receptor	54	Mediates interaction with SH3BP4.				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		TTGTGACATTGGCCTTTGTGT	0.433000			T	BCL6	NHL								32	71					0	0	1	0	0
USP48	84196	broad.mit.edu	37	1	22030035	22030035	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:22030035G>C	ENST00000308271.9	-	21	3240	c.2592C>G	c.(2590-2592)atC>atG	p.I864M	USP48_ENST00000529637.1_Missense_Mutation_p.I876M|USP48_ENST00000400301.1_Missense_Mutation_p.I864M|USP48_ENST00000374732.3_Missense_Mutation_p.I402M	NM_032236.5	NP_115612.4	Q86UV5	UBP48_HUMAN	ubiquitin specific peptidase 48	864					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(14)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		TATGGACATAGATGGTGGCTT	0.433000													22	103					0	0	1	0	0
IGHV5-51	28388	broad.mit.edu	37	14	107034806	107034806	+	RNA	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr14:107034806C>T	ENST00000390626.2	-	0	332																											ATGGACTTGTCGGCTGAGATG	0.582000													5	69					0	0	1	0	0
TBC1D10C	374403	broad.mit.edu	37	11	67172885	67172885	+	Missense_Mutation	SNP	C	C	T	rs141022722		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:67172885C>T	ENST00000312390.5	+	4	297	c.268C>T	c.(268-270)Cgg>Tgg	p.R90W	TBC1D10C_ENST00000526387.1_Missense_Mutation_p.R90W|TBC1D10C_ENST00000542590.1_Missense_Mutation_p.R90W	NM_198517.3	NP_940919.1	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	90						intracellular	Rab GTPase activator activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GATGCAGTGCCGGAAAGGCAT	0.647000													3	10					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32164700	32164700	+	Splice_Site	SNP	A	A	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:32164700A>G	ENST00000375023.3	-	28	5339		c.e28+1		NOTCH4_ENST00000443903.2_Splice_Site	NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4						cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						TCCTCTACATACCCCATTTAT	0.542000													15	83					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45872380	45872380	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:45872380G>A	ENST00000391945.4	-	3	208	c.131C>T	c.(130-132)tCa>tTa	p.S44L	ERCC2_ENST00000221481.6_Missense_Mutation_p.S44L|ERCC2_ENST00000391940.4_Missense_Mutation_p.S20L|ERCC2_ENST00000391944.3_Missense_Mutation_p.S44L|ERCC2_ENST00000485403.2_Missense_Mutation_p.S20L	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	44	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCCGGTGCCTGAGGGCATCTC	0.587000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				14	53					0	0	1	0	0
LRPPRC	10128	broad.mit.edu	37	2	44162006	44162006	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:44162006G>A	ENST00000260665.7	-	24	2573	c.2516C>T	c.(2515-2517)tCt>tTt	p.S839F		NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	839					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AAGAGCAGTAGATAGGTCGCC	0.358000													23	26					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610589	47610589	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:47610589G>A	ENST00000371891.3	+	9	1200	c.1169G>A	c.(1168-1170)gGa>gAa	p.G390E	CYP4A22_ENST00000371890.3_Missense_Mutation_p.G292E|CYP4A22_ENST00000294337.3_Missense_Mutation_p.G390E|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000485117.1_3'UTR	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	390						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CCAGGCATTGGAAGAGAGCTC	0.572000													3	22					0	0	1	0	0
DBF4	10926	broad.mit.edu	37	7	87506068	87506068	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:87506068G>A	ENST00000265728.1	+	1	525	c.21G>A	c.(19-21)agG>agA	p.R7R		NM_006716.3	NP_006707.1	Q9UBU7	DBF4A_HUMAN	DBF4 homolog (S. cerevisiae)	7					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|skin(3)	28	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				GAGCCATGAGGATCCACAGTA	0.597000													3	13					0	0	1	0	0
SH2D4A	63898	broad.mit.edu	37	8	19192208	19192208	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr8:19192208C>G	ENST00000265807.3	+	4	764	c.353C>G	c.(352-354)tCt>tGt	p.S118C	SH2D4A_ENST00000519207.1_Missense_Mutation_p.S118C|SH2D4A_ENST00000518040.1_Missense_Mutation_p.S73C	NM_001174160.1|NM_022071.3	NP_001167631.1|NP_071354.2	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	118						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|stomach(1)	16				Colorectal(111;0.0732)		AAAACTCACTCTGAAGAATTC	0.388000													15	26					0	0	1	0	0
SIK3	23387	broad.mit.edu	37	11	116797980	116797980	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:116797980C>A	ENST00000375300.1	-	4	576	c.571G>T	c.(571-573)Gct>Tct	p.A191S	SIK3_ENST00000542607.1_Missense_Mutation_p.A133S|SIK3_ENST00000446921.2_Missense_Mutation_p.A191S|SIK3_ENST00000292055.4_Missense_Mutation_p.A133S|SIK3_ENST00000375288.1_5'UTR|SIK3_ENST00000434315.2_Missense_Mutation_p.A32S			Q9Y2K2	SIK3_HUMAN	SIK family kinase 3	133	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	57						AAATTTTCAGCTTTTAAATCA	0.418000													4	65					0.00909568	0.00923144	1	1	0
OR10J1	26476	broad.mit.edu	37	1	159410055	159410055	+	Silent	SNP	G	G	A	rs149860482		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:159410055G>A	ENST00000423932.3	+	1	544	c.507G>A	c.(505-507)acG>acA	p.T169T	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	169					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TAGCAATAACGCAAGTGACAT	0.502000													12	97					0	0	1	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110035681	110035681	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:110035681C>G	ENST00000453089.2	+	5	2659	c.1778C>G	c.(1777-1779)tCt>tGt	p.S593C	ZC3H12C_ENST00000278590.3_Missense_Mutation_p.S624C|ZC3H12C_ENST00000528673.1_Missense_Mutation_p.S625C			Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	624							endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		TCCGTAGCTTCTGACTGCAGC	0.512000													4	24					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183732067	183732067	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:183732067G>A	ENST00000334444.6	-	2	354	c.114C>T	c.(112-114)ttC>ttT	p.F38F	ABCC5_ENST00000427120.2_Silent_p.F38F|ABCC5_ENST00000265586.6_Silent_p.F38F|ABCC5_ENST00000392579.2_Silent_p.F38F|ABCC5_ENST00000382494.2_Silent_p.F38F|ABCC5_ENST00000446941.2_Silent_p.F38F	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	38						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GAGTTCTCCTGAACTTGGAAT	0.428000													13	43					0	0	1	0	0
WDR44	54521	broad.mit.edu	37	X	117576206	117576206	+	Splice_Site	SNP	G	G	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:117576206G>T	ENST00000254029.3	+	16	2561		c.e16-1		WDR44_ENST00000371822.5_Splice_Site|WDR44_ENST00000371825.3_Splice_Site	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44							cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						TTTATTTTTAGCATTTGAAAT	0.408000													8	81					3.09899e-07	3.27222e-07	1	1	0
VGLL3	389136	broad.mit.edu	37	3	87017893	87017893	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:87017893G>T	ENST00000398399.2	-	3	1147	c.784C>A	c.(784-786)Ctg>Atg	p.L262M	VGLL3_ENST00000383698.3_Missense_Mutation_p.L262M	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	262					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GGCATCAGCAGAGGCCCATAG	0.597000													6	18					4.096e-09	4.36564e-09	1	1	0
ABCC5	10057	broad.mit.edu	37	3	183643492	183643492	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr3:183643492C>T	ENST00000334444.6	-	29	4303	c.4063G>A	c.(4063-4065)Gaa>Aaa	p.E1355K	ABCC5_ENST00000265586.6_Missense_Mutation_p.E1312K	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	1355	ABC transporter 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCTGTGGCTTCATCTAAAATC	0.408000													12	44					0	0	1	0	0
NUDT12	83594	broad.mit.edu	37	5	102888061	102888061	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:102888061C>A	ENST00000230792.2	-	6	1231	c.1135G>T	c.(1135-1137)Gtt>Ttt	p.V379F	NUDT12_ENST00000507423.1_Missense_Mutation_p.V361F	NM_031438.2	NP_113626.1	Q9BQG2	NUD12_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 12	379	Nudix hydrolase.					nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity			endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|urinary_tract(1)	12		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		ACATGGCCAACTTTGACTCCA	0.418000													3	49					0.150653	0.151995	1	1	0
TRERF1	55809	broad.mit.edu	37	6	42222655	42222655	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:42222655C>A	ENST00000541110.1	-	13	3218	c.2650G>T	c.(2650-2652)Gaa>Taa	p.E884*	TRERF1_ENST00000372922.4_Nonsense_Mutation_p.E864*|TRERF1_ENST00000340840.2_Nonsense_Mutation_p.E781*|TRERF1_ENST00000372917.4_Nonsense_Mutation_p.E781*|TRERF1_ENST00000354325.2_Nonsense_Mutation_p.E781*			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	864	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGCAGCATTTCCAGAGCAACC	0.507000													15	71					1.3612e-06	1.42842e-06	1	1	0
KMT2E	55904	broad.mit.edu	37	7	104753155	104753155	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:104753155C>T	ENST00000334877.4	+	26	5360	c.4826C>T	c.(4825-4827)tCt>tTt	p.S1609F	SRPK2_ENST00000493638.1_Intron|KMT2E_ENST00000257745.4_Missense_Mutation_p.S1651F|KMT2E_ENST00000311117.3_Missense_Mutation_p.S1651F					lysine (K)-specific methyltransferase 2E																		CAGCAACACTCTGTAGCACAT	0.582000													10	33					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25000724	25000724	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr13:25000724C>G	ENST00000381989.3	-	33	4964	c.4859G>C	c.(4858-4860)aGa>aCa	p.R1620T		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1620	Interaction with the major vault protein.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		GAGACATTCTCTTCCTTTTAC	0.368000													8	46					0	0	1	0	0
OR6K3	391114	broad.mit.edu	37	1	158687162	158687162	+	Silent	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:158687162C>G	ENST00000368146.1	-	1	791	c.792G>C	c.(790-792)ccG>ccC	p.P264P	OR6K3_ENST00000368145.1_Silent_p.P248P			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	264			P -> L (in dbSNP:rs28568406).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					CAAAGAATATCGGGAAGACCA	0.453000													13	38					0	0	1	0	0
C12orf43	64897	broad.mit.edu	37	12	121454196	121454196	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:121454196C>T	ENST00000288757.3	-	1	104	c.82G>A	c.(82-84)Gag>Aag	p.E28K	C12orf43_ENST00000536407.2_Missense_Mutation_p.E28K|C12orf43_ENST00000537817.1_5'UTR|C12orf43_ENST00000445832.3_5'UTR|C12orf43_ENST00000539736.1_Missense_Mutation_p.E28K|C12orf43_ENST00000366211.2_5'UTR	NM_022895.1	NP_075046.1	Q96C57	CL043_HUMAN	chromosome 12 open reading frame 43	28								p.E28Q(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATTGCCGCCTCGCGGCACCGC	0.637000													3	19					0	0	1	0	0
CHM	1121	broad.mit.edu	37	X	85218981	85218981	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:85218981T>A	ENST00000357749.2	-	5	420	c.391A>T	c.(391-393)Aca>Tca	p.T131S	CHM_ENST00000467744.2_Intron|CHM_ENST00000537751.1_5'UTR	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	131					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				GCAGCTTCTGTGGAGTTTGCA	0.428000													15	51					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163693224	163693224	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr2:163693224A>T	ENST00000332142.5	-	2	229	c.130T>A	c.(130-132)Tgc>Agc	p.C44S	KCNH7_ENST00000328032.4_Missense_Mutation_p.C44S	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	44	PAS.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CCATCGTTGCAATAAATGATG	0.433000													16	50					0	0	1	0	0
ACE2	59272	broad.mit.edu	37	X	15610443	15610443	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:15610443C>G	ENST00000427411.1	-	4	564	c.348G>C	c.(346-348)ttG>ttC	p.L116F	ACE2_ENST00000252519.3_Missense_Mutation_p.L116F	NM_021804.2	NP_068576.1	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2	116					angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	32	Hepatocellular(33;0.183)				Moexipril(DB00691)	GAATTGTGTTCAACTGCAAAT	0.313000													24	83					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159184535	159184535	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr6:159184535G>A	ENST00000297239.9	+	16	1911	c.1717G>A	c.(1717-1719)Ggt>Agt	p.G573S	SYTL3_ENST00000360448.3_Missense_Mutation_p.G505S|SYTL3_ENST00000367081.3_Missense_Mutation_p.G299S			Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	573					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		AACCAGACTTGGTTCAAGTAA	0.483000													16	26					0	0	1	0	0
SUV420H1	51111	broad.mit.edu	37	11	67957455	67957455	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr11:67957455G>A	ENST00000304363.4	-	2	442	c.89C>T	c.(88-90)tCa>tTa	p.S30L	SUV420H1_ENST00000405515.1_Missense_Mutation_p.S30L|SUV420H1_ENST00000402185.2_Missense_Mutation_p.S30L|SUV420H1_ENST00000401547.2_Missense_Mutation_p.S30L|SUV420H1_ENST00000402789.1_Missense_Mutation_p.S30L	NM_017635.3	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	30					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						CTGTAATTTTGATTGATTCTG	0.463000													42	140					0	0	1	0	0
AIF1L	83543	broad.mit.edu	37	9	133989974	133989974	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr9:133989974G>A	ENST00000372309.3	+	5	403	c.249G>A	c.(247-249)atG>atA	p.M83I	AIF1L_ENST00000247291.3_Missense_Mutation_p.M57I|AIF1L_ENST00000372302.1_Missense_Mutation_p.M57I|AIF1L_ENST00000372301.2_Start_Codon_SNP_p.M1I|AIF1L_ENST00000372312.3_Missense_Mutation_p.M62I|AIF1L_ENST00000372297.2_Start_Codon_SNP_p.M1I|AIF1L_ENST00000372300.1_Missense_Mutation_p.M57I|AIF1L_ENST00000372298.1_Missense_Mutation_p.M57I	NM_001185095.1	NP_001172024.1	Q9BQI0	AIF1L_HUMAN	allograft inflammatory factor 1-like	57	EF-hand 2; degenerate.					actin cytoskeleton|cytoplasm|focal adhesion|ruffle membrane	actin filament binding|calcium ion binding			lung(2)	2						AGAAGTACATGGAGTTTGACC	0.517000													7	106					0	0	1	0	0
FAM13B	51306	broad.mit.edu	37	5	137321065	137321065	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:137321065C>T	ENST00000033079.3	-	10	1511	c.1060G>A	c.(1060-1062)Gat>Aat	p.D354N	FAM13B_ENST00000420893.2_Missense_Mutation_p.D354N|FAM13B_ENST00000425075.2_Missense_Mutation_p.D236N	NM_016603.2	NP_057687.2	Q9NYF5	FA13B_HUMAN	family with sequence similarity 13, member B	354					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(4)|kidney(2)|lung(5)	11						ATAATATCATCAGCAATATCA	0.328000													12	66					0	0	1	0	0
SLC13A4	26266	broad.mit.edu	37	7	135387595	135387595	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr7:135387595C>T	ENST00000354042.4	-	6	1317	c.628G>A	c.(628-630)Gag>Aag	p.E210K		NM_012450.2	NP_036582.2	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 4	210						integral to plasma membrane	sodium:sulfate symporter activity	p.E210K(1)|p.E210*(1)		breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	24						GGCCATACCTCGTTGTGCATC	0.522000													11	68					0	0	1	0	0
METTL23	124512	broad.mit.edu	37	17	74729619	74729619	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr17:74729619G>A	ENST00000341249.6	+	5	756	c.424G>A	c.(424-426)Gaa>Aaa	p.E142K	METTL23_ENST00000590964.1_Missense_Mutation_p.E75K|METTL23_ENST00000588822.1_Missense_Mutation_p.E75K|METTL23_ENST00000586738.1_3'UTR|METTL23_ENST00000586752.1_Missense_Mutation_p.E75K|METTL23_ENST00000586200.1_Missense_Mutation_p.E23K|RP11-318A15.7_ENST00000587459.1_Intron|METTL23_ENST00000588302.1_3'UTR|METTL23_ENST00000591571.1_3'UTR|METTL23_ENST00000588783.1_3'UTR	NM_001206984.1	NP_001193913.1	Q86XA0	MET23_HUMAN	methyltransferase like 23	142						integral to membrane	methyltransferase activity			large_intestine(2)|lung(1)	3						CTGGTCACTTGAAGCTTTACT	0.348000													37	128					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3831263	3831263	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr16:3831263G>A	ENST00000262367.5	-	7	2427	c.1618C>T	c.(1618-1620)Cag>Tag	p.Q540*	CREBBP_ENST00000382070.3_Nonsense_Mutation_p.Q502*	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	540					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GGGGGCTGCTGATCTGTTGTT	0.403000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						8	19					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86189082	86189082	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr15:86189082G>A	ENST00000394518.2	+	10	4366	c.4271G>A	c.(4270-4272)aGa>aAa	p.R1424K	AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000361243.2_Missense_Mutation_p.R1424K|RP11-815J21.4_ENST00000558980.1_RNA	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1424					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GGACTGGGCAGAGAGTGTACC	0.368000													13	63					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63009810	63009810	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr15:63009810G>A	ENST00000561311.1	+	23	3029	c.2799G>A	c.(2797-2799)caG>caA	p.Q933Q	TLN2_ENST00000306829.6_Silent_p.Q933Q			Q9Y4G6	TLN2_HUMAN	talin 2	933	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						CAGCCACACAGACCATCGCCG	0.557000													3	8					0	0	1	0	0
LRRC14	9684	broad.mit.edu	37	8	145746448	145746448	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr8:145746448C>T	ENST00000292524.1	+	4	1214	c.1068C>T	c.(1066-1068)ttC>ttT	p.F356F	LRRC14_ENST00000529022.1_Silent_p.F356F	NM_001272036.1|NM_014665.2	NP_001258965.1|NP_055480.1	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	356										endometrium(1)|lung(3)|prostate(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGGCACCCTTCCAGGGTCTGT	0.597000													10	37					0	0	1	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204380099	204380099	+	Silent	SNP	G	G	A			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:204380099G>A	ENST00000367188.4	-	1	820	c.441C>T	c.(439-441)atC>atT	p.I147I	RP11-739N20.2_ENST00000443515.1_RNA	NM_032833.3	NP_116222.3	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	147					regulation of translation					breast(3)|cervix(1)|kidney(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(2)|skin(1)|urinary_tract(3)	34	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			ATTGCCAGTGGATCCCCTCCT	0.567000													4	75					0	0	1	0	0
SHANK3	85358	broad.mit.edu	37	22	51154122	51154122	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr22:51154122C>G	ENST00000414786.2	+	20	2476	c.2249C>G	c.(2248-2250)cCa>cGa	p.P750R	SHANK3_ENST00000445220.2_Missense_Mutation_p.P766R|SHANK3_ENST00000262795.3_Missense_Mutation_p.P780R			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	780										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CAGGGCCTCCCAGGCCCAGAG	0.642000													10	58					0	0	1	0	0
TSSK1B	83942	broad.mit.edu	37	5	112770104	112770104	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr5:112770104C>G	ENST00000390666.3	-	1	624	c.433G>C	c.(433-435)Gac>Cac	p.D145H	MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000416046.2_RNA|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	145	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		AAGTCCTTGTCAAGGAGAAGG	0.547000													5	33					0	0	1	0	0
TFCP2	7024	broad.mit.edu	37	12	51512554	51512554	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:51512554C>T	ENST00000307660.4	-	2	844	c.124G>A	c.(124-126)Gat>Aat	p.D42N	TFCP2_ENST00000548115.1_Splice_Site_p.D42N|TFCP2_ENST00000549867.1_Splice_Site_p.D42N|TFCP2_ENST00000257915.5_Splice_Site_p.D42N	NM_001173453.1	NP_001166924.1	Q12800	TFCP2_HUMAN	transcription factor CP2	42					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	23						GCAAGGACATCACTAAAATAA	0.378000													21	74					0	0	1	0	0
PTPN7	5778	broad.mit.edu	37	1	202123440	202123440	+	Silent	SNP	C	C	T			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:202123440C>T	ENST00000309017.3	-	6	1568	c.795G>A	c.(793-795)ggG>ggA	p.G265G	PTPN7_ENST00000544762.1_Intron|PTPN7_ENST00000492977.1_5'UTR|PTPN7_ENST00000308986.5_Silent_p.G160G|PTPN7_ENST00000543735.1_5'UTR|PTPN7_ENST00000367279.4_Silent_p.G199G	NM_001199797.1|NM_002832.3	NP_001186726.1|NP_002823.3	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type 7	160	Tyrosine-protein phosphatase.					cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|soft_tissue(1)|urinary_tract(1)	13						CCTTCTCCTTCCCGTCATAGC	0.597000													4	15					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803276	142803278	+	RNA	DEL	AAC	AAC	-			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr1:142803276_142803278delAAC	ENST00000423385.1	-	0	1687_1689																											ACCAAACCAAaacaacaacaaca	0.345													2	4	---	---	---	---					
SLC39A5	283375	broad.mit.edu	37	12	56630264	56630272	+	In_Frame_Del	DEL	CAGGCAGCT	CAGGCAGCT	-	rs143285853		TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:56630264_56630272delCAGGCAGCT	ENST00000266980.4	+	7	1323_1331	c.1030_1038delCAGGCAGCT	c.(1030-1038)caggcagctdel	p.QAA344del	SLC39A5_ENST00000454355.2_In_Frame_Del_p.QAA344del	NM_001135195.1	NP_001128667.1	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (zinc transporter), member 5	344					zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			NS(1)|cervix(6)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TCAGCCCCTACAGGCAGCTCCAGGTGACT	0.536													7	24	---	---	---	---					
RAB21	23011	broad.mit.edu	37	12	72148989	72148989	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr12:72148989delA	ENST00000261263.3	+	1	336	c.80delA	c.(79-81)gaafs	p.E27fs		NM_014999.2	NP_055814.1	Q9UL25	RAB21_HUMAN	RAB21, member RAS oncogene family	27					protein transport|small GTPase mediated signal transduction	cleavage furrow|cytoplasmic vesicle membrane|early endosome membrane|endoplasmic reticulum membrane|Golgi membrane	GDP binding|GTP binding|GTPase activity|protein binding			large_intestine(1)|lung(4)|prostate(1)	6						CTGCTGGGGGAAGGCTGCGTG	0.716													2	4	---	---	---	---					
SPRED3	399473	broad.mit.edu	37	19	38882864	38882866	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chr19:38882864_38882866delCCT	ENST00000587013.1	+	3	569_571	c.491_493delCCT	c.(490-495)ccctcc>ccc	p.S172del	SPRED3_ENST00000587564.2_3'UTR|SPRED3_ENST00000338502.4_In_Frame_Del_p.S128del|SPRED3_ENST00000586301.1_In_Frame_Del_p.S128del			Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	128					multicellular organismal development					central_nervous_system(2)|large_intestine(1)|lung(5)|skin(1)	9	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TCACTCAccccctcctcctcctc	0.645													3	6	---	---	---	---					
STAG2	10735	broad.mit.edu	37	X	123171472	123171480	+	Splice_Site	DEL	AGGTAAGAT	AGGTAAGAT	-			TCGA-ZF-A9RG-01A-21D-A42E-08	TCGA-ZF-A9RG-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69daea4-d849-4a78-8ee3-3463829dceda	1c783347-b3b6-4b41-a92b-d81def8ce2a3	g.chrX:123171472_123171480delAGGTAAGAT	ENST00000371160.1	+	6	674_675	c.384_385delAGGTAAGAT	c.(382-387)aaaggt>aagt	p.G129del	STAG2_ENST00000371144.3_Splice_Site_p.G129del|STAG2_ENST00000354548.5_Splice_Site_p.G60del|STAG2_ENST00000371157.3_Splice_Site_p.G129del|STAG2_ENST00000218089.9_Splice_Site_p.G129del|STAG2_ENST00000371145.3_Splice_Site_p.G129del|STAG2_ENST00000469481.1_Intron	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	129					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						CAGGCTGTAAAGGTAAGATATATTTATTT	0.359													7	89	---	---	---	---					
