Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZMYM2	7750	broad.mit.edu	37	13	20608406	20608406	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr13:20608406C>G	ENST00000382869.3	+	11	2232	c.1981C>G	c.(1981-1983)Cag>Gag	p.Q661E	ZMYM2_ENST00000382883.3_Missense_Mutation_p.Q143E|ZMYM2_ENST00000382874.2_Missense_Mutation_p.Q661E|ZMYM2_ENST00000382871.2_Missense_Mutation_p.Q661E	NM_001190965.1|NM_003453.3|NM_197968.2	NP_001177894.1|NP_003444.1|NP_932072.1	Q9UBW7	ZMYM2_HUMAN	zinc finger, MYM-type 2	661					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CAAAGTGCATCAGTTCTGCAG	0.363000													16	22					0	0	1	0	0
CSAG1	158511	broad.mit.edu	37	X	151909197	151909197	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chrX:151909197G>T	ENST00000370287.3	+	5	554	c.226G>T	c.(226-228)Ggc>Tgc	p.G76C	CSAG1_ENST00000452779.2_Missense_Mutation_p.G76C|CSAG1_ENST00000370291.2_3'UTR	NM_153478.1	NP_705611.1	Q6PB30	CSAG1_HUMAN	chondrosarcoma associated gene 1	76										central_nervous_system(1)|kidney(1)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAACAAAAGGCTCTCCCTA	0.512000													38	21					1.58521e-26	1.83054e-26	1	1	0
PRDM9	56979	broad.mit.edu	37	5	23526872	23526872	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr5:23526872C>T	ENST00000296682.3	+	11	1857	c.1675C>T	c.(1675-1677)Cgg>Tgg	p.R559W		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	559					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.R559R(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GGAGTGTGGGCGGGGCTTTAG	0.527000										HNSCC(3;0.000094)			20	77					0	0	1	0	0
RNASE4	6038	broad.mit.edu	37	14	21161760	21161760	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr14:21161760G>A	ENST00000553909.1	+	2	227	c.37G>A	c.(37-39)Gtg>Atg	p.V13M	RP11-903H12.3_ENST00000554286.1_RNA|ANG_ENST00000554073.1_Intron|RNASE4_ENST00000397995.2_Intron|ANG_ENST00000397990.4_Missense_Mutation_p.V13M|RNASE4_ENST00000555597.1_Intron|RNASE4_ENST00000304704.4_5'UTR|ANG_ENST00000336811.6_Missense_Mutation_p.V13M|RNASE4_ENST00000555835.1_Intron	NM_001282192.1	NP_001269121.1																					GTTGGTCTTCGTGCTGGGTCT	0.577000													22	43					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49791133	49791133	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr10:49791133G>T	ENST00000249601.4	-	2	395	c.99C>A	c.(97-99)caC>caA	p.H33Q	ARHGAP22_ENST00000435790.2_Missense_Mutation_p.H39Q|ARHGAP22_ENST00000417912.2_Missense_Mutation_p.H33Q|ARHGAP22_ENST00000491108.1_5'UTR	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	33					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GGCCCAGCCTGTGAGGGCACG	0.622000													4	173					0.248553	0.251142	1	1	0
NFASC	23114	broad.mit.edu	37	1	204956556	204956556	+	Silent	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:204956556C>T	ENST00000367172.4	+	24	3130	c.2802C>T	c.(2800-2802)gcC>gcT	p.A934A	NFASC_ENST00000338586.6_Silent_p.A934A|NFASC_ENST00000404907.1_Silent_p.A930A|NFASC_ENST00000539706.1_Silent_p.A930A|NFASC_ENST00000367170.4_Silent_p.A934A|NFASC_ENST00000367171.4_Silent_p.A919A|NFASC_ENST00000495396.1_3'UTR|NFASC_ENST00000367169.4_Silent_p.A827A|NFASC_ENST00000338515.6_Silent_p.A934A|NFASC_ENST00000404076.1_Silent_p.A913A|NFASC_ENST00000339876.6_Silent_p.A827A|NFASC_ENST00000513543.1_Silent_p.A930A|NFASC_ENST00000401399.1_Silent_p.A827A|NFASC_ENST00000360049.4_Silent_p.A930A			O94856	NFASC_HUMAN	neurofascin	934	Fibronectin type-III 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TACCCAGTGCCCCTAGGCGTT	0.537000													9	26					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122399901	122399901	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr3:122399901C>G	ENST00000474629.2	+	1	437	c.171C>G	c.(169-171)ttC>ttG	p.F57L		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	57					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		TCCTGGTGTTCTTCTACCCGG	0.672000													10	10					0	0	1	0	0
GPRC5D	55507	broad.mit.edu	37	12	13102644	13102644	+	Silent	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr12:13102644C>T	ENST00000228887.1	-	1	674	c.675G>A	c.(673-675)ctG>ctA	p.L225L	RP11-392P7.6_ENST00000542078.1_RNA|RP11-392P7.6_ENST00000545914.1_RNA|RP11-392P7.6_ENST00000540198.1_RNA|RP11-392P7.6_ENST00000543515.2_RNA|GPRC5D_ENST00000396333.3_Silent_p.L225L|RP11-392P7.6_ENST00000536029.1_RNA|RP11-392P7.6_ENST00000394742.3_RNA	NM_018654.1	NP_061124.1	Q9NZD1	GPC5D_HUMAN	G protein-coupled receptor, family C, group 5, member D	225						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(2)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GGTTGCCTCTCAGGAGCATGG	0.567000													17	47					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803552	142803552	+	RNA	SNP	T	T	A	rs141013493	by1000genomes	TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:142803552T>A	ENST00000423385.1	-	0	1413																											TCCTGATGAATCTGCAGTCAG	0.269000													5	83					0	0	1	0	0
RECQL5	9400	broad.mit.edu	37	17	73658559	73658559	+	Splice_Site	SNP	C	C	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr17:73658559C>A	ENST00000420326.2	-	4	930	c.771G>T	c.(769-771)ggG>ggT	p.G257G	RECQL5_ENST00000423245.2_Splice_Site_p.G230G|RECQL5_ENST00000340830.5_Splice_Site_p.G257G|RECQL5_ENST00000584999.1_Splice_Site_p.G257G|RECQL5_ENST00000317905.5_Splice_Site_p.G257G	NM_001003715.3|NM_001003716.3	NP_001003715.1|NP_001003716.1	O94762	RECQ5_HUMAN	RecQ protein-like 5	257	Helicase C-terminal.				DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			breast(1)|cervix(3)|endometrium(3)|kidney(7)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	36	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			AATGCCTCACCCCTTTATCAG	0.478000								Other identified genes with known or suspected DNA repair function					66	198					3.4266e-16	3.91036e-16	1	1	0
CEBPA	1050	broad.mit.edu	37	19	33792453	33792453	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr19:33792453C>T	ENST00000498907.2	-	1	1017	c.868G>A	c.(868-870)Gag>Aag	p.E290K	CTD-2540B15.7_ENST00000587312.1_RNA	NM_004364.3	NP_004355.2	P49715	CEBPA_HUMAN	CCAAT/enhancer binding protein (C/EBP), alpha	290					cytokine-mediated signaling pathway|generation of precursor metabolites and energy|interspecies interaction between organisms|positive regulation of transcription from RNA polymerase III promoter		sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding	p.E290*(1)|p.H200_K352>Q(1)|p.?(1)		cervix(1)|haematopoietic_and_lymphoid_tissue(912)|lung(5)|prostate(1)|stomach(1)	920	Esophageal squamous(110;0.137)					TTGTTGCGCTCGCGCCGCACC	0.682000			"""Mis, N, F"""		"""AML, MDS"""				Acute Myeloid Leukemia, Familial, associated with CEBPA germline mutation				13	26					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73376573	73376573	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr9:73376573T>A	ENST00000377110.3	-	8	1459	c.1216A>T	c.(1216-1218)Acc>Tcc	p.T406S	TRPM3_ENST00000377101.1_Missense_Mutation_p.T253S|TRPM3_ENST00000357533.2_Missense_Mutation_p.T408S|TRPM3_ENST00000396280.5_Missense_Mutation_p.T253S|TRPM3_ENST00000423814.3_Missense_Mutation_p.T433S|TRPM3_ENST00000358082.3_Missense_Mutation_p.T278S|TRPM3_ENST00000377106.1_Missense_Mutation_p.T278S|TRPM3_ENST00000396292.4_Missense_Mutation_p.T278S|TRPM3_ENST00000360823.2_Missense_Mutation_p.T278S|TRPM3_ENST00000396285.1_Missense_Mutation_p.T253S|TRPM3_ENST00000377105.1_Missense_Mutation_p.T253S|TRPM3_ENST00000408909.2_Missense_Mutation_p.T253S|TRPM3_ENST00000377111.2_Missense_Mutation_p.T406S			Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3							integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TGAGCTTGGGTTCGAGTGTAT	0.438000													6	25					0	0	1	0	0
PAK2	5062	broad.mit.edu	37	3	196533474	196533474	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr3:196533474C>G	ENST00000327134.3	+	6	815	c.493C>G	c.(493-495)Ccc>Gcc	p.P165A		NM_002577.4	NP_002568.2	Q13177	PAK2_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 2	165					axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			breast(1)|cervix(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	12	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		AACAGAAGCACCCGCAGTAGT	0.493000													11	27					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15975538	15975538	+	Silent	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr17:15975538C>T	ENST00000268712.3	-	29	4073	c.3816G>A	c.(3814-3816)ctG>ctA	p.L1272L	NCOR1_ENST00000395857.3_Intron|NCOR1_ENST00000395851.1_Silent_p.L1288L	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1272	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTCGGCATATCAGCCCTTCCA	0.378000													10	33					0	0	1	0	0
ZMYND12	84217	broad.mit.edu	37	1	42898923	42898923	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:42898923G>C	ENST00000372565.3	-	7	1135	c.866C>G	c.(865-867)aCt>aGt	p.T289S	ZMYND12_ENST00000475426.1_5'UTR|ZMYND12_ENST00000433602.2_Missense_Mutation_p.T179S	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	289						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CAAGATTGAAGTCAGGATGCG	0.433000													5	152					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71508020	71508020	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr4:71508020C>T	ENST00000396073.3	+	9	1158	c.877C>T	c.(877-879)Cct>Tct	p.P293S	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	293					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			TGGCCCACTCCCTGCAGTCAA	0.512000													20	25					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15326078	15326078	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr10:15326078C>T	ENST00000378116.4	-	2	130	c.124G>A	c.(124-126)Gac>Aac	p.D42N		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	42						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GTGCTGGCGTCGCTGATGTGC	0.542000													3	35					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125047530	125047530	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr8:125047530C>T	ENST00000522917.1	+	19	2505	c.2299C>T	c.(2299-2301)Cga>Tga	p.R767*	FER1L6-AS1_ENST00000518567.1_RNA|FER1L6_ENST00000399018.1_Nonsense_Mutation_p.R767*	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	767						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCCTGGGAAACGACCGGCTGG	0.493000													17	47					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140070222	140070222	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr9:140070222C>T	ENST00000323927.2	-	11	1962	c.1958G>A	c.(1957-1959)cGc>cAc	p.R653H	ANAPC2_ENST00000487917.1_5'UTR	NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	653					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		AGACAGCGTGCGGTCGGCCAG	0.662000													9	18					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47954001	47954001	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr21:47954001C>A	ENST00000318711.7	+	12	1700	c.1517C>A	c.(1516-1518)aCa>aAa	p.T506K	DIP2A_ENST00000457905.3_Missense_Mutation_p.T505K|DIP2A_ENST00000435722.3_Missense_Mutation_p.T505K|DIP2A_ENST00000466639.1_Missense_Mutation_p.T462K|DIP2A_ENST00000417564.2_Missense_Mutation_p.T505K|DIP2A_ENST00000427143.2_Missense_Mutation_p.T441K|DIP2A_ENST00000400274.1_Missense_Mutation_p.T501K	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	505					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GCCCAGGACACAGGGACTGGG	0.502000													4	22					0.184627	0.188514	1	1	0
KIAA1143	57456	broad.mit.edu	37	3	44803050	44803050	+	Silent	SNP	C	C	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr3:44803050C>A	ENST00000296121.4	-	1	104	c.45G>T	c.(43-45)ccG>ccT	p.P15P		NM_020696.3	NP_065747.1	Q96AT1	K1143_HUMAN	KIAA1143	15										NS(1)|breast(1)|central_nervous_system(1)|large_intestine(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.00847)|KIRC - Kidney renal clear cell carcinoma(197;0.0465)|Kidney(197;0.0582)		CCAGAAACGCCGGCTCGGCTG	0.602000													3	31					0.115264	0.120222	1	1	0
OSR1	130497	broad.mit.edu	37	2	19552087	19552087	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr2:19552087C>G	ENST00000536433.1	-	2	3860	c.750G>C	c.(748-750)aaG>aaC	p.K250N	OSR1_ENST00000272223.2_Missense_Mutation_p.K250N			Q8TAX0	OSR1_HUMAN	odd-skipped related transciption factor 1	250					chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|heart development|mesangial cell development|mesonephric duct morphogenesis|metanephric cap mesenchymal cell proliferation involved in metanephros development|metanephric glomerulus vasculature development|metanephric interstitial cell development|metanephric mesenchymal cell differentiation|metanephric nephron tubule development|metanephric smooth muscle tissue development|middle ear morphogenesis|negative regulation of apoptosis|negative regulation of nephron tubule epithelial cell differentiation|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|pattern specification involved in metanephros development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of gastrulation|positive regulation of transcription from RNA polymerase II promoter|pronephros development|renal vesicle progenitor cell differentiation|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|stem cell differentiation|transcription, DNA-dependent|ureter urothelium development|ureteric bud development	nucleolus	nucleic acid binding|zinc ion binding			breast(1)|large_intestine(2)|lung(4)|ovary(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	Acute lymphoblastic leukemia(84;0.221)				AGTGTAGCGTCTTGTGGACAG	0.517000													45	63					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551442	248551442	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:248551442T>A	ENST00000355728.2	+	1	533	c.533T>A	c.(532-534)tTc>tAc	p.F178Y		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AATCACTTTTTCTGTGAGGCA	0.532000													4	36					0	0	1	0	0
NDUFA8	4702	broad.mit.edu	37	9	124914591	124914591	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr9:124914591C>G	ENST00000537618.1	-	2	257	c.148G>C	c.(148-150)Gag>Cag	p.E50Q	NDUFA8_ENST00000373768.3_Missense_Mutation_p.E50Q			P51970	NDUA8_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa	50	CHCH 1.				mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9					NADH(DB00157)	GGATCTTTCTCTTCCCAGCGG	0.458000													12	33					0	0	1	0	0
ARID4A	5926	broad.mit.edu	37	14	58831239	58831239	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr14:58831239C>T	ENST00000355431.3	+	20	2805	c.2432C>T	c.(2431-2433)tCa>tTa	p.S811L	ARID4A_ENST00000348476.3_Missense_Mutation_p.S811L|ARID4A_ENST00000395168.3_Missense_Mutation_p.S811L|ARID4A_ENST00000431317.2_Missense_Mutation_p.S811L	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	811					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						AAGATTTCATCATTTGGCCAG	0.333000													15	43					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37880257	37880257	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr17:37880257C>G	ENST00000406381.2	+	21	2721	c.2211C>G	c.(2209-2211)atC>atG	p.I737M	ERBB2_ENST00000584601.1_Missense_Mutation_p.I737M|ERBB2_ENST00000584450.1_Missense_Mutation_p.I767M|ERBB2_ENST00000269571.5_Missense_Mutation_p.I767M|ERBB2_ENST00000540147.1_Missense_Mutation_p.I737M|ERBB2_ENST00000541774.1_Missense_Mutation_p.I752M|ERBB2_ENST00000445658.2_Missense_Mutation_p.I491M	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	767	Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.I767M(2)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ACAAAGAAATCTTAGACGTAA	0.542000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			7	12					0	0	1	0	0
SMC4	10051	broad.mit.edu	37	3	160148907	160148907	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr3:160148907G>C	ENST00000357388.3	+	20	3479	c.3028G>C	c.(3028-3030)Gat>Cat	p.D1010H	SMC4_ENST00000469762.1_Missense_Mutation_p.D985H|SMC4_ENST00000344722.5_Missense_Mutation_p.D1010H|RP11-432B6.3_ENST00000483754.1_Intron|SMC4_ENST00000360111.2_Intron|SMC4_ENST00000462787.1_Intron	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	1010					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TCTTCAAAAAGATGCACTTAG	0.328000													36	33					0	0	1	0	0
ZACN	353174	broad.mit.edu	37	17	74076414	74076414	+	Silent	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr17:74076414C>T	ENST00000334586.5	+	5	536	c.453C>T	c.(451-453)ctC>ctT	p.L151L	ZACN_ENST00000392503.2_Intron	NM_180990.3	NP_851321.2	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	151					response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity	p.L150L(1)		breast(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	11						ACCTGGCCCTCGCCACGGAGA	0.632000													12	68					0	0	1	0	0
EPN1	29924	broad.mit.edu	37	19	56206575	56206575	+	Silent	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr19:56206575C>T	ENST00000411543.2	+	11	2389	c.1842C>T	c.(1840-1842)ctC>ctT	p.L614L	EPN1_ENST00000085079.7_Silent_p.L502L|EPN1_ENST00000270460.6_Silent_p.L528L	NM_001130071.1	NP_001123543.1	Q9Y6I3	EPN1_HUMAN	epsin 1	528					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	17		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		CCGCGACGCTCACCCTGAACC	0.677000													9	21					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179454225	179454225	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr2:179454225C>T	ENST00000589042.1	-	304	62451	c.62227G>A	c.(62227-62229)Gtg>Atg	p.V20743M	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V18175M|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V11803M|TTN_ENST00000460472.2_Missense_Mutation_p.V11678M|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V11870M|TTN_ENST00000591111.1_Missense_Mutation_p.V19102M|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19102	Fibronectin type-III 50.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGTTTGCACTCTGAACTCA	0.398000													28	14					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994573	140994573	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chrX:140994573T>G	ENST00000285879.4	+	4	1669	c.1383T>G	c.(1381-1383)agT>agG	p.S461R	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	461							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTTTCCAGAGTTCCCCTGAGA	0.483000										HNSCC(15;0.026)			13	118					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120306960	120306960	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr12:120306960G>C	ENST00000392521.2	-	3	197	c.142C>G	c.(142-144)Cga>Gga	p.R48G	CIT_ENST00000261833.7_Missense_Mutation_p.R48G	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	48					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		ATCCCTTCTCGGGAAAGAGGA	0.433000													10	124					0	0	1	0	0
C4B	721	broad.mit.edu	37	6	31996297	31996297	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr6:31996297G>A	ENST00000435363.2	+	25	3302	c.3218G>A	c.(3217-3219)gGc>gAc	p.G1073D	C4B_ENST00000425700.2_Missense_Mutation_p.G1073D	NM_001002029.3	NP_001002029.3	P0C0L5	CO4B_HUMAN	complement component 4B (Chido blood group)	1073			D -> G (in allotype C4B1 and allotype C4B3; dbSNP:rs2258218).		complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity										TTGTCACGGGGCAGCAGCACC	0.617000													3	16					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102446830	102446830	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr14:102446830G>T	ENST00000360184.4	+	5	1068	c.904G>T	c.(904-906)Gat>Tat	p.D302Y		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	302	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CCTGACTCTGGATATCTTGAA	0.443000													4	42					0.00909568	0.00959001	1	1	0
MUC5B	727897	broad.mit.edu	37	11	1271261	1271261	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr11:1271261C>G	ENST00000447027.1	+	31	13218	c.13160C>G	c.(13159-13161)tCc>tGc	p.S4387C	MUC5B_ENST00000529681.1_Missense_Mutation_p.S4384C			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4384	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACCCCCTCCTCCACTCCGGGG	0.667000													37	71					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22828017	22828017	+	Silent	SNP	A	A	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:22828017A>G	ENST00000404138.1	+	5	1375	c.864A>G	c.(862-864)ggA>ggG	p.G288G	ZBTB40_ENST00000375647.4_Silent_p.G288G|ZBTB40_ENST00000374651.4_Intron	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	288					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GTGAAGGAGGACATTCAGCAT	0.438000													19	37					0	0	1	0	0
FBXO46	23403	broad.mit.edu	37	19	46216543	46216543	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr19:46216543G>C	ENST00000317683.3	-	2	344	c.211C>G	c.(211-213)Ccg>Gcg	p.P71A		NM_001080469.1	NP_001073938.1	Q6PJ61	FBX46_HUMAN	F-box protein 46	71							protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	15		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		GAGAGGAGCGGAGCCGGCTGG	0.642000													15	52					0	0	1	0	0
NOL8	55035	broad.mit.edu	37	9	95077919	95077919	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr9:95077919C>T	ENST00000545558.1	-	7	1480	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K	NOL8_ENST00000442668.2_Missense_Mutation_p.E330K|NOL8_ENST00000542053.1_Missense_Mutation_p.E262K|NOL8_ENST00000535387.1_Missense_Mutation_p.E330K|NOL8_ENST00000358855.4_Missense_Mutation_p.E262K			Q76FK4	NOL8_HUMAN	nucleolar protein 8	330					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						GGATCACTTTCAGATTCATTT	0.353000													9	10					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63532475	63532475	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr17:63532475G>A	ENST00000307078.5	-	8	2417	c.2104C>T	c.(2104-2106)Cgc>Tgc	p.R702C	AXIN2_ENST00000375702.5_Missense_Mutation_p.R637C	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	702					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						GCTAGCCTGCGACAGGCCTCC	0.657000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				4	14					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432680	73432680	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr3:73432680T>G	ENST00000263666.4	-	10	3151	c.3037A>C	c.(3037-3039)Aag>Cag	p.K1013Q	PDZRN3_ENST00000462146.2_Missense_Mutation_p.K670Q|PDZRN3_ENST00000535920.1_Missense_Mutation_p.K735Q|PDZRN3_ENST00000479530.1_Missense_Mutation_p.K730Q|PDZRN3_ENST00000466780.1_Missense_Mutation_p.K670Q	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	1013							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TTCATCTCCTTCCTGTCATCG	0.502000													4	110					0	0	1	0	0
SAMD4B	55095	broad.mit.edu	37	19	39868164	39868164	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr19:39868164G>T	ENST00000314471.6	+	10	2179	c.1144G>T	c.(1144-1146)Gag>Tag	p.E382*	SAMD4B_ENST00000596368.1_Intron|SAMD4B_ENST00000598913.1_Nonsense_Mutation_p.E382*	NM_018028.2	NP_060498.2	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	382							protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(2)	15	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CGCTCTGCAGGAGCTGCAGCA	0.607000													3	58					1	1	1	1	0
CUL9	23113	broad.mit.edu	37	6	43160845	43160845	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr6:43160845G>A	ENST00000252050.4	+	9	2371	c.2287G>A	c.(2287-2289)Gag>Aag	p.E763K	CUL9_ENST00000354495.3_Missense_Mutation_p.E653K|CUL9_ENST00000372647.2_Missense_Mutation_p.E763K	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	763					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						GACCAAGCACGAGTGGCGGCC	0.587000													5	204					0	0	1	0	0
MEF2A	4205	broad.mit.edu	37	15	100215643	100215643	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr15:100215643G>C	ENST00000354410.5	+	7	1285	c.656G>C	c.(655-657)gGa>gCa	p.G219A	MEF2A_ENST00000449277.2_Missense_Mutation_p.G149A|MEF2A_ENST00000338042.6_Missense_Mutation_p.G217A|MEF2A_ENST00000557942.1_Missense_Mutation_p.G217A|MEF2A_ENST00000557785.1_Missense_Mutation_p.G217A|MEF2A_ENST00000453228.2_Missense_Mutation_p.G217A|MEF2A_ENST00000558812.1_Missense_Mutation_p.G149A	NM_005587.2	NP_005578.2	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A	219					apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			endometrium(2)|large_intestine(2)|lung(7)|ovary(1)	12	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			GTGCCAAATGGAGCTGGAAGC	0.428000													21	36					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59271368	59271368	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr12:59271368C>G	ENST00000320743.3	-	15	2636	c.2350G>C	c.(2350-2352)Gtg>Ctg	p.V784L	LRIG3_ENST00000379141.4_Missense_Mutation_p.V724L	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	784						integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			GTGGGGATCACACTGAGGCGC	0.532000			T	ROS1	NSCLC								3	50					0	0	1	0	0
OR2AG1	144125	broad.mit.edu	37	11	6807092	6807092	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr11:6807092C>G	ENST00000307401.4	+	1	845	c.824C>G	c.(823-825)tCt>tGt	p.S275C		NM_001004489.2	NP_001004489.1	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG, member 1	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AACATCATCTCTGTTTTCTAC	0.498000													20	31					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41768138	41768138	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr13:41768138G>C	ENST00000379483.3	-	1	564	c.256C>G	c.(256-258)Cgc>Ggc	p.R86G		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	86	BTB.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		AGCACGTTGCGATTGCAGGAA	0.612000													25	12					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115226976	115226976	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:115226976C>T	ENST00000369538.3	-	4	525	c.478G>A	c.(478-480)Gaa>Aaa	p.E160K	AMPD1_ENST00000353928.6_Missense_Mutation_p.E131K|AMPD1_ENST00000520113.2_Missense_Mutation_p.E164K	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	131					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TCAAAATCTTCAACTGTAACC	0.418000													12	17					0	0	1	0	0
KIAA0753	9851	broad.mit.edu	37	17	6493171	6493171	+	Missense_Mutation	SNP	C	C	T	rs61735434		TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr17:6493171C>T	ENST00000361413.3	-	18	3072	c.2714G>A	c.(2713-2715)cGt>cAt	p.R905H	KIAA0753_ENST00000575027.1_5'UTR|KIAA0753_ENST00000589033.1_Missense_Mutation_p.R361H|KIAA0753_ENST00000542606.1_Missense_Mutation_p.R606H|KIAA0753_ENST00000572370.1_Missense_Mutation_p.R606H	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	905						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		CTGCTCAAAACGACTACAGTA	0.507000													10	38					0	0	1	0	0
KIAA1143	57456	broad.mit.edu	37	3	44803049	44803049	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr3:44803049C>A	ENST00000296121.4	-	1	105	c.46G>T	c.(46-48)Gcg>Tcg	p.A16S		NM_020696.3	NP_065747.1	Q96AT1	K1143_HUMAN	KIAA1143	16										NS(1)|breast(1)|central_nervous_system(1)|large_intestine(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.00847)|KIRC - Kidney renal clear cell carcinoma(197;0.0465)|Kidney(197;0.0582)		GCCAGAAACGCCGGCTCGGCT	0.602000													4	31					0.150653	0.155462	1	1	0
OR8B2	26595	broad.mit.edu	37	11	124252925	124252925	+	Silent	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr11:124252925G>C	ENST00000375013.2	-	1	333	c.315C>G	c.(313-315)ctC>ctG	p.L105L		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TGACGAAAAAGAGAAAGAAAA	0.393000													11	42					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3788653	3788653	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr16:3788653A>C	ENST00000262367.5	-	26	5110	c.4301T>G	c.(4300-4302)cTg>cGg	p.L1434R	CREBBP_ENST00000382070.3_Missense_Mutation_p.L1396R	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1434	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.L1434P(1)		NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AATACTATCCAGATAAGAAAT	0.433000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						5	12					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228560599	228560599	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:228560599G>T	ENST00000570156.2	+	105	25065	c.24991G>T	c.(24991-24993)Gtg>Ttg	p.V8331L	OBSCN_ENST00000422127.1_Missense_Mutation_p.V7374L|OBSCN_ENST00000366707.4_Missense_Mutation_p.V5008L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7374					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GTCAGAGGATGTGGACGCGCT	0.687000													5	9					1.23904e-05	1.36576e-05	1	1	0
TRA2B	6434	broad.mit.edu	37	3	185636210	185636210	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr3:185636210G>C	ENST00000453386.2	-	8	1074	c.799C>G	c.(799-801)Cct>Gct	p.P267A	TRA2B_ENST00000382191.4_Missense_Mutation_p.P167A	NM_004593.2	NP_004584.1	P62995	TRA2B_HUMAN	transformer 2 beta homolog (Drosophila)	267	Arg/Ser-rich (RS2 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	18						CTATAGTAAGGAGAAGGTGAC	0.348000													17	45					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102446829	102446829	+	Silent	SNP	G	G	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr14:102446829G>T	ENST00000360184.4	+	5	1067	c.903G>T	c.(901-903)ctG>ctT	p.L301L		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	301	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TCCTGACTCTGGATATCTTGA	0.448000													4	44					0.00909568	0.00959001	1	1	0
TRA2B	6434	broad.mit.edu	37	3	185636168	185636168	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr3:185636168G>C	ENST00000453386.2	-	8	1116	c.841C>G	c.(841-843)Cga>Gga	p.R281G	TRA2B_ENST00000382191.4_Missense_Mutation_p.R181G	NM_004593.2	NP_004584.1	P62995	TRA2B_HUMAN	transformer 2 beta homolog (Drosophila)	281	Arg/Ser-rich (RS2 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	18						GAGTATGATCGAGATCTGGAA	0.368000													19	49					0	0	1	0	0
TMEM168	64418	broad.mit.edu	37	7	112423860	112423860	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr7:112423860C>G	ENST00000312814.6	-	2	1581	c.1021G>C	c.(1021-1023)Gat>Cat	p.D341H	TMEM168_ENST00000454074.1_Missense_Mutation_p.D341H	NM_022484.4	NP_071929.3	Q9H0V1	TM168_HUMAN	transmembrane protein 168							integral to membrane|transport vesicle				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|stomach(1)	32						ATGATTCTATCAAGGCTATTG	0.368000													44	69					0	0	1	0	0
DDX19B	11269	broad.mit.edu	37	16	70359561	70359561	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr16:70359561A>C	ENST00000288071.6	+	7	822	c.577A>C	c.(577-579)Aag>Cag	p.K193Q	DDX19B_ENST00000355992.3_Missense_Mutation_p.K162Q|DDX19B_ENST00000393657.2_Missense_Mutation_p.K84Q|RP11-529K1.3_ENST00000567706.1_Missense_Mutation_p.K193Q|DDX19B_ENST00000451014.3_Missense_Mutation_p.K167Q|RP11-529K1.2_ENST00000562077.1_RNA|DDX19B_ENST00000568625.1_Missense_Mutation_p.K84Q|DDX19B_ENST00000563392.1_Missense_Mutation_p.K84Q|DDX19B_ENST00000563206.1_Missense_Mutation_p.K198Q	NM_007242.5	NP_009173.1	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B	193	Helicase ATP-binding.				mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|prostate(1)	9		Ovarian(137;0.0694)				CCCTGAACTGAAGCTAGCTTA	0.388000													8	155					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63672422	63672422	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr11:63672422G>A	ENST00000402010.2	+	16	2420	c.1841G>A	c.(1840-1842)gGt>gAt	p.G614D	MARK2_ENST00000508192.1_Missense_Mutation_p.G559D|MARK2_ENST00000509502.2_Missense_Mutation_p.G580D|MARK2_ENST00000502399.3_Missense_Mutation_p.G613D|MARK2_ENST00000413835.2_Missense_Mutation_p.G560D|MARK2_ENST00000377810.3_Missense_Mutation_p.G526D|MARK2_ENST00000350490.7_Missense_Mutation_p.G559D|MARK2_ENST00000408948.3_Missense_Mutation_p.G526D|MARK2_ENST00000377809.4_Missense_Mutation_p.G614D|MARK2_ENST00000425897.2_Missense_Mutation_p.G534D|MARK2_ENST00000513765.2_Missense_Mutation_p.G581D|MARK2_ENST00000315032.8_Missense_Mutation_p.G614D|MARK2_ENST00000361128.5_Missense_Mutation_p.G560D	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	614					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						TTGCCCTACGGTGTGACCCCA	0.637000													4	84					0	0	1	0	0
SEPT7	989	broad.mit.edu	37	7	35930362	35930362	+	Silent	SNP	T	T	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr7:35930362T>C	ENST00000494488.2	+	10	915	c.915T>C	c.(913-915)taT>taC	p.Y305Y	SEPT7_ENST00000399035.3_Silent_p.Y318Y|SEPT7_ENST00000432293.2_Intron|SEPT7_ENST00000350320.6_Silent_p.Y318Y|SEPT7_ENST00000399034.2_Silent_p.Y320Y|SEPT7_ENST00000435235.1_Silent_p.Y266Y			Q16181	SEPT7_HUMAN	septin 7	319					cilium morphogenesis|cytokinesis|mitosis|protein heterooligomerization|regulation of embryonic cell shape	cilium axoneme|cleavage furrow|condensed chromosome kinetochore|midbody|nucleus|septin complex|spindle|stress fiber	GTP binding|protein binding|structural molecule activity	p.Y320Y(3)		central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)	14						CTGTGACTTATAATGGAGTTG	0.323000													4	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179466775	179466775	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr2:179466775G>T	ENST00000589042.1	-	284	55447	c.55223C>A	c.(55222-55224)cCa>cAa	p.P18408Q	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P15840Q|TTN_ENST00000359218.5_Missense_Mutation_p.P9468Q|TTN_ENST00000460472.2_Missense_Mutation_p.P9343Q|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P9535Q|TTN_ENST00000591111.1_Missense_Mutation_p.P16767Q|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16767	Fibronectin type-III 33.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATGATTTTGGTGTTGGGCG	0.413000													9	69					0.000274275	0.000298929	1	1	0
NUP205	23165	broad.mit.edu	37	7	135276234	135276234	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr7:135276234C>G	ENST00000285968.6	+	11	1536	c.1510C>G	c.(1510-1512)Ctg>Gtg	p.L504V	NUP205_ENST00000440390.2_Intron	NM_015135.2	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	504					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						AATGGGTGACCTGTTGCCTCC	0.403000													16	33					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153907309	153907309	+	Silent	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:153907309C>T	ENST00000361217.4	-	18	3118	c.2700G>A	c.(2698-2700)caG>caA	p.Q900Q		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	900	Gln-rich.							p.Q788Q(1)|p.Q900Q(1)		NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgttgctgctgctgct	0.642000													4	60					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179422059	179422059	+	Silent	SNP	G	G	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr2:179422059G>A	ENST00000589042.1	-	329	88154	c.87930C>T	c.(87928-87930)ttC>ttT	p.F29310F	TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Silent_p.F26742F|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000359218.5_Silent_p.F20370F|TTN_ENST00000460472.2_Silent_p.F20245F|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Silent_p.F20437F|TTN_ENST00000591111.1_Silent_p.F27669F|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	27669	Ig-like 134.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATACACCCTGAATTCATAAA	0.418000													16	73					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33944984	33944984	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:33944984C>G	ENST00000361328.3	+	2	248	c.95C>G	c.(94-96)tCa>tGa	p.S32*	ZSCAN20_ENST00000373413.2_Nonsense_Mutation_p.S32*|ZSCAN20_ENST00000480917.1_3'UTR	NM_145238.3	NP_660281	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	32					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TCTTGGGGATCAGAATCCAAA	0.567000													12	35					0	0	1	0	0
STEAP1	26872	broad.mit.edu	37	7	89793976	89793976	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr7:89793976G>C	ENST00000297205.2	+	5	1148	c.948G>C	c.(946-948)aaG>aaC	p.K316N	STEAP2-AS1_ENST00000478318.2_RNA	NM_012449.2	NP_036581.1	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the prostate 1	316					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			kidney(2)|large_intestine(3)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	14	all_hematologic(106;0.112)					TGAGGAAGAAGATACTGAAGA	0.353000													5	53					0	0	1	0	0
AHRR	57491	broad.mit.edu	37	5	434243	434243	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr5:434243G>A	ENST00000316418.5	+	12	1498	c.1454G>A	c.(1453-1455)cGg>cAg	p.R485Q	AHRR_ENST00000505113.1_Missense_Mutation_p.R467Q|AHRR_ENST00000506456.1_Missense_Mutation_p.R323Q|AHRR_ENST00000512529.1_Missense_Mutation_p.R313Q	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			TACTCCAGCCGGACCAGCAGA	0.687000													3	44					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71068906	71068906	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr8:71068906G>A	ENST00000452400.2	-	11	1875	c.1694C>T	c.(1693-1695)tCc>tTc	p.S565F	NCOA2_ENST00000524223.1_Intron	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	565					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			ATTAACTGGGGAGTTTTGCAA	0.507000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								6	81					0	0	1	0	0
S100PBP	64766	broad.mit.edu	37	1	33291869	33291869	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:33291869G>C	ENST00000373475.5	+	3	423	c.169G>C	c.(169-171)Gag>Cag	p.E57Q	S100PBP_ENST00000398243.3_Missense_Mutation_p.E57Q|S100PBP_ENST00000373476.1_Missense_Mutation_p.E57Q|S100PBP_ENST00000356689.3_3'UTR	NM_022753.3	NP_073590.2	Q96BU1	S1PBP_HUMAN	S100P binding protein	57						nucleus	calcium-dependent protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|stomach(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CACAGAGGAAGAGATTGATGC	0.453000													11	67					0	0	1	0	0
VAMP8	8673	broad.mit.edu	37	2	85808784	85808784	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr2:85808784T>C	ENST00000263864.5	+	3	404	c.248T>C	c.(247-249)aTt>aCt	p.I83T	VAMP8_ENST00000432071.1_Missense_Mutation_p.I57T|VAMP8_ENST00000409760.1_3'UTR	NM_003761.4	NP_003752.2	Q9BV40	VAMP8_HUMAN	vesicle-associated membrane protein 8	83					post-Golgi vesicle-mediated transport	early endosome|integral to membrane|membrane fraction|plasma membrane|secretory granule membrane				breast(1)|endometrium(2)|large_intestine(1)|stomach(2)	6						ATCTGCGTGATTGTTTTTATC	0.478000													113	156					0	0	1	0	0
EXOC6	54536	broad.mit.edu	37	10	94688173	94688173	+	Silent	SNP	G	G	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr10:94688173G>A	ENST00000371552.4	+	9	980	c.951G>A	c.(949-951)tcG>tcA	p.S317S	EXOC6_ENST00000443748.2_Silent_p.S299S|EXOC6_ENST00000371547.4_Silent_p.S338S|EXOC6_ENST00000260762.6_Silent_p.S322S	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	322					protein transport|vesicle docking involved in exocytosis	exocyst		p.S322S(1)|p.S317S(1)		cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				AACCCCAGTCGAATATGGTAA	0.338000													11	33					0	0	1	0	0
FBLIM1	54751	broad.mit.edu	37	1	16095061	16095061	+	Silent	SNP	C	C	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:16095061C>G	ENST00000375766.3	+	5	1117	c.477C>G	c.(475-477)ctC>ctG	p.L159L	FBLIM1_ENST00000441801.2_Silent_p.L159L|FBLIM1_ENST00000400773.1_Intron|FBLIM1_ENST00000332305.5_Intron|FBLIM1_ENST00000375771.1_Silent_p.L159L	NM_017556.2	NP_060026.2	Q8WUP2	FBLI1_HUMAN	filamin binding LIM protein 1	159	Pro-rich.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	16		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		CCGGTCCCCTCAGGCCCATGG	0.647000													3	25					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198265452	198265452	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr2:198265452T>C	ENST00000335508.6	-	18	2796	c.2705A>G	c.(2704-2706)gAa>gGa	p.E902G		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa						nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTAGTCTGTTCTTGGAAAGC	0.318000			Mis		myelodysplastic syndrome								20	16					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963952	88963952	+	Silent	SNP	T	T	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr7:88963952T>C	ENST00000333190.4	+	4	2265	c.1656T>C	c.(1654-1656)taT>taC	p.Y552Y		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	552						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGAGGAAATATAATTTGGACT	0.343000										HNSCC(36;0.09)			3	53					0	0	1	0	0
HIST2H2BE	8349	broad.mit.edu	37	1	149858166	149858166	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:149858166G>C	ENST00000369155.2	-	1	66	c.25C>G	c.(25-27)Ccg>Gcg	p.P9A		NM_003528.2	NP_003519.1	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	9					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	14	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TTAGGGGCCGGAGCGGATTTT	0.517000													170	42					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91770134	91770134	+	Silent	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr14:91770134C>T	ENST00000389857.6	-	20	3632	c.3546G>A	c.(3544-3546)tcG>tcA	p.S1182S		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1182					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CGTACTCGGCCGATTGCCGCT	0.637000													5	22					0	0	1	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75926239	75926239	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr8:75926239T>A	ENST00000262207.4	+	5	996	c.528T>A	c.(526-528)agT>agA	p.S176R	CRISPLD1_ENST00000523524.1_5'UTR|CRISPLD1_ENST00000517786.1_Intron	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	176						extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			GGGCAACTAGTAACAGAATCG	0.408000													17	52					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106209357	106209357	+	RNA	SNP	T	T	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr14:106209357T>A	ENST00000390548.2	-	0	51																											CCCCCAGAGGTGCTCTTGGAG	0.672000													8	18					0	0	1	0	0
ZNF609	23060	broad.mit.edu	37	15	64970407	64970407	+	Silent	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr15:64970407C>T	ENST00000326648.3	+	5	3623	c.3495C>T	c.(3493-3495)cgC>cgT	p.R1165R		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	1165						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AGCGGGACCGCAAATTGAAGG	0.532000													7	27					0	0	1	0	0
LRRC34	151827	broad.mit.edu	37	3	169514140	169514140	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr3:169514140T>G	ENST00000522526.2	-	8	1267	c.830A>C	c.(829-831)gAt>gCt	p.D277A	LRRC34_ENST00000316515.7_Missense_Mutation_p.D264A|LRRC34_ENST00000522830.1_Missense_Mutation_p.D248A|LRRC34_ENST00000524327.1_5'UTR|LRRC34_ENST00000446859.1_Missense_Mutation_p.D309A			Q8IZ02	LRC34_HUMAN	leucine rich repeat containing 34	264										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(2)	10	all_cancers(22;4.12e-22)|all_epithelial(15;7.54e-27)|all_lung(20;1.63e-16)|Lung NSC(18;6.92e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			CACCATTCCATCATGAGTTAT	0.323000													29	37					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75115175	75115175	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr2:75115175C>T	ENST00000290573.2	+	16	2965	c.2365C>T	c.(2365-2367)Cag>Tag	p.Q789*	HK2_ENST00000409174.1_Nonsense_Mutation_p.Q761*	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	789	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						GTTCTTGTCTCAGATTGAGAG	0.502000													16	71					0	0	1	0	0
MYF6	4618	broad.mit.edu	37	12	81101624	81101624	+	Silent	SNP	C	C	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr12:81101624C>A	ENST00000228641.3	+	1	348	c.126C>A	c.(124-126)tcC>tcA	p.S42S		NM_002469.2	NP_002460.1	P23409	MYF6_HUMAN	myogenic factor 6 (herculin)	42					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						GTACCTTGTCCCCCTGCCAGG	0.602000													21	32					3.62473e-10	4.08836e-10	1	1	0
CDK12	51755	broad.mit.edu	37	17	37627275	37627275	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr17:37627275C>T	ENST00000447079.4	+	2	1223	c.1190C>T	c.(1189-1191)gCt>gTt	p.A397V	CDK12_ENST00000430627.2_Missense_Mutation_p.A397V	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	397					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						AGTCTGGGAGCTGAACTCAGT	0.448000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			4	43					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71508833	71508833	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr4:71508833A>G	ENST00000396073.3	+	9	1971	c.1690A>G	c.(1690-1692)Aga>Gga	p.R564G	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	564					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			TCCTGCTGGAAGAAATACTTG	0.438000													4	205					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	130988406	130988406	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr9:130988406T>C	ENST00000393594.3	+	10	1343	c.1289T>C	c.(1288-1290)aTg>aCg	p.M430T	DNM1_ENST00000341179.7_Intron|DNM1_ENST00000372923.3_Intron|DNM1_ENST00000475805.1_Missense_Mutation_p.M430T|DNM1_ENST00000486160.1_Missense_Mutation_p.M430T			Q05193	DYN1_HUMAN	dynamin 1	430					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						TGTGTGGATATGGTAGTCAGT	0.572000													10	25					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282139	152282139	+	Silent	SNP	C	C	A			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr1:152282139C>A	ENST00000368799.1	-	3	5258	c.5223G>T	c.(5221-5223)ggG>ggT	p.G1741G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1741	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGATGGGGCCCAGCCTGTC	0.587000									Ichthyosis				8	461					3.09899e-07	3.45519e-07	1	1	0
GZMK	3003	broad.mit.edu	37	5	54326341	54326341	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr5:54326341G>T	ENST00000231009.2	+	3	362	c.292G>T	c.(292-294)Gag>Tag	p.E98*	CTD-2313F11.1_ENST00000609699.1_RNA|CTD-2313F11.1_ENST00000609792.1_RNA|CTD-2313F11.1_ENST00000595218.1_RNA|CTD-2313F11.1_ENST00000596137.1_RNA	NM_002104.2	NP_002095.1	P49863	GRAK_HUMAN	granzyme K (granzyme 3; tryptase II)	98	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)	15		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				ACAAACACTGGAGATCAAAAA	0.393000													121	54					1.81606e-51	2.12238e-51	1	1	0
NACA	4666	broad.mit.edu	37	12	57114946	57114946	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr12:57114946A>G	ENST00000454682.1	-	3	649	c.368T>C	c.(367-369)aTa>aCa	p.I123T	NACA_ENST00000393891.4_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Missense_Mutation_p.I123T|NACA_ENST00000548563.1_Intron|NACA_ENST00000546392.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	55	NAC-A/B.				interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						AGTTGGAGCTATCATGGGAGA	0.557000			T	BCL6	NHL								3	17					0	0	1	0	0
PTMA	5757	broad.mit.edu	37	2	232577170	232577171	+	Frame_Shift_Ins	INS	-	-	AT			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr2:232577170_232577171insAT	ENST00000409115.3	+	4	427_428	c.229_230insAT	c.(229-231)gatfs	p.D77fs	PTMA_ENST00000466801.1_3'UTR|PTMA_ENST00000409321.1_Frame_Shift_Ins_p.D98fs|PTMA_ENST00000410064.1_Frame_Shift_Ins_p.D103fs|PTMA_ENST00000341369.7_Frame_Shift_Ins_p.D78fs|PTMA_ENST00000409683.1_Frame_Shift_Ins_p.D74fs	NM_002823.4	NP_002814.3	P06454	PTMA_HUMAN	prothymosin, alpha	78	Asp/Glu-rich (acidic).				transcription, DNA-dependent	nucleus				lung(3)|ovary(1)|prostate(1)|skin(1)	6		Renal(207;0.0112)|all_hematologic(139;0.0315)|Acute lymphoblastic leukemia(138;0.0921)|all_lung(227;0.142)		Epithelial(121;1.75e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00221)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		AGAGGATGGAGATGAAGATGAG	0.545													16	22	---	---	---	---					
MLXIPL	51085	broad.mit.edu	37	7	73012016	73012016	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr7:73012016delC	ENST00000313375.3	-	9	1146	c.1099delG	c.(1099-1101)gacfs	p.D367fs	MLXIPL_ENST00000434326.1_Frame_Shift_Del_p.D274fs|MLXIPL_ENST00000414749.2_Frame_Shift_Del_p.D367fs|MLXIPL_ENST00000429400.2_Frame_Shift_Del_p.D367fs|MLXIPL_ENST00000395189.1_Frame_Shift_Del_p.D274fs|MLXIPL_ENST00000354613.1_Frame_Shift_Del_p.D367fs	NM_032951.2|NM_032953.2	NP_116569.1|NP_116571.1	Q9NP71	WBS14_HUMAN	MLX interacting protein-like	367					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			cervix(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13		Lung NSC(55;0.0659)|all_lung(88;0.152)				GCGCTGGAGTCCAAGGGGCCA	0.652													10	17	---	---	---	---					
GTF2I	2969	broad.mit.edu	37	7	74149837	74149840	+	Frame_Shift_Del	DEL	AAGA	AAGA	-			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr7:74149837_74149840delAAGA	ENST00000324896.4	+	17	1787_1790	c.1398_1401delAAGA	c.(1396-1401)ttaagafs	p.LR466fs	GTF2I_ENST00000346152.4_Frame_Shift_Del_p.LR445fs|GTF2I_ENST00000416070.1_Frame_Shift_Del_p.LR425fs|GTF2I_ENST00000353920.4_Frame_Shift_Del_p.LR446fs	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi	466					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						TCACTAAATTAAGAAAGATGGTGG	0.275													2	4	---	---	---	---					
ZFAT	57623	broad.mit.edu	37	8	135596075	135596077	+	Splice_Site	DEL	CAT	CAT	-			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr8:135596075_135596077delCAT	ENST00000520727.1	-	11	3148_3150	c.2849_2851delATG	c.(2848-2853)gatggg>ggg	p.D950del	ZFAT_ENST00000523399.1_Splice_Site_p.D900del|ZFAT_ENST00000517307.1_5'UTR|ZFAT_ENST00000377838.3_Splice_Site_p.D962del|ZFAT_ENST00000520356.1_Splice_Site_p.D950del|ZFAT_ENST00000429442.2_Splice_Site_p.D950del|ZFAT_ENST00000520214.1_Splice_Site_p.D950del	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	962					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			ATTTACTCACCATCTGCAGTGTG	0.443													8	14	---	---	---	---					
METTL21B	25895	broad.mit.edu	37	12	58168420	58168420	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr12:58168420delG	ENST00000333012.5	+	3	345	c.298delG	c.(298-300)ggtfs	p.G100fs	METTL21B_ENST00000548256.1_Frame_Shift_Del_p.G58fs|METTL21B_ENST00000552307.1_3'UTR|METTL21B_ENST00000300209.8_Intron|RP11-571M6.15_ENST00000471530.1_Intron|RP11-571M6.15_ENST00000553083.1_Intron|METTL21B_ENST00000551420.1_Intron	NM_206914.1	NP_996797.1	Q96AZ1	MT21B_HUMAN	methyltransferase like 21B	0						integral to membrane|intracellular	methyltransferase activity			endometrium(1)|lung(1)	2						aggagcttatggtctagtgag	0.448													2	4	---	---	---	---					
SUPT20H	55578	broad.mit.edu	37	13	37598509	37598512	+	Frame_Shift_Del	DEL	TTGA	TTGA	-			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr13:37598509_37598512delTTGA	ENST00000360252.4	-	18	1647_1650	c.1400_1403delTCAA	c.(1399-1404)atcaaafs	p.IK467fs	SUPT20H_ENST00000475892.1_Frame_Shift_Del_p.IK466fs|SUPT20H_ENST00000464744.1_Frame_Shift_Del_p.IK467fs|SUPT20H_ENST00000542180.1_Frame_Shift_Del_p.IK430fs|SUPT20H_ENST00000350612.6_Frame_Shift_Del_p.IK466fs|SUPT20H_ENST00000356185.3_Frame_Shift_Del_p.IK467fs	NM_001278481.1|NM_001278482.1|NM_017569.3	NP_001265410.1|NP_001265411.1|NP_060039.1			suppressor of Ty 20 homolog (S. cerevisiae)																		TGAGGGAAGTTTGATTGGTGGGGG	0.348													19	25	---	---	---	---					
MYH1	4619	broad.mit.edu	37	17	10399677	10399677	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr17:10399677delT	ENST00000226207.5	-	34	4940	c.4846delA	c.(4846-4848)attfs	p.I1616fs	CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA|RP11-799N11.1_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1616						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TTGAGCCTAATGGCATCATTC	0.478													7	126	---	---	---	---					
EFCAB5	374786	broad.mit.edu	37	17	28417687	28417688	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr17:28417687_28417688delTC	ENST00000394835.3	+	20	4124_4125	c.3932_3933delTC	c.(3931-3933)atcfs	p.I1311fs	EFCAB5_ENST00000394832.2_Intron|EFCAB5_ENST00000320856.5_Frame_Shift_Del_p.I1187fs|RP11-1148O4.2_ENST00000582938.1_RNA	NM_198529.3	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	1311							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						AAAAAATATATCTTAGGTATCG	0.356													19	48	---	---	---	---					
CEP76	79959	broad.mit.edu	37	18	12699828	12699829	+	Splice_Site	INS	-	-	T			TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr18:12699828_12699829insT	ENST00000262127.2	-	3	520_521		c.e3+1		CEP76_ENST00000423709.2_Splice_Site|PSMG2_ENST00000585331.2_Intron|CEP76_ENST00000586887.1_Splice_Site	NM_024899.2	NP_079175.2	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa						G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding	p.T99fs*90(1)		endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AATATACATACTTTTTTTTAAT	0.317													2	4	---	---	---	---					
CTD-2245F17.3	0	broad.mit.edu	37	19	53703995	53703996	+	RNA	DEL	TT	TT	-	rs113703393		TCGA-ZF-AA4R-01A-11D-A38G-08	TCGA-ZF-AA4R-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1027053d-438e-4f01-9655-b6e2e8376e66	a60524a1-b806-4678-ad16-69f1629ed79f	g.chr19:53703995_53703996delTT	ENST00000597550.1	+	0	232																											TGTTTCCCCCtttttttttttt	0.475													3	5	---	---	---	---					
