Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF516	9658	broad.mit.edu	37	18	74091847	74091847	+	Silent	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr18:74091847C>A	ENST00000443185.2	-	4	2540	c.2223G>T	c.(2221-2223)cgG>cgT	p.R741R	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	741					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		TGGGGTCATCCCGCGTCGACC	0.597000													12	34					6.42651e-13	7.45475e-13	1	1	0
NKTR	4820	broad.mit.edu	37	3	42680097	42680097	+	Silent	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:42680097G>A	ENST00000232978.8	+	13	3089	c.2901G>A	c.(2899-2901)tcG>tcA	p.S967S	RP4-613B23.1_ENST00000445452.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	967					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GTTCCAATTCGGAAAACAATA	0.408000													4	91					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	248355	248355	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr12:248355C>G	ENST00000538872.1	+	4	1944	c.1826C>G	c.(1825-1827)tCa>tGa	p.S609*	IQSEC3_ENST00000326261.4_Nonsense_Mutation_p.S609*|IQSEC3_ENST00000382841.2_Nonsense_Mutation_p.S306*|RP11-598F7.4_ENST00000505893.2_RNA			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	609					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TCCGCCAAGTCAGGCTCGGAG	0.692000													2	2					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121981099	121981099	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:121981099C>G	ENST00000498619.1	+	4	1655	c.1217C>G	c.(1216-1218)aCc>aGc	p.T406S	CASR_ENST00000296154.5_Missense_Mutation_p.T406S|CASR_ENST00000490131.1_Missense_Mutation_p.T406S	NM_001178065.1	NP_001171536	P41180	CASR_HUMAN	calcium-sensing receptor	406					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AGTGTCGAGACCCCTTACATA	0.478000													13	83					0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57982879	57982879	+	Silent	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr11:57982879C>T	ENST00000309433.6	+	1	663	c.663C>T	c.(661-663)atC>atT	p.I221I		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				CAGTTATCATCTTCCCCTTTA	0.443000													52	52					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71756826	71756826	+	Silent	SNP	G	G	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr5:71756826G>C	ENST00000318442.5	-	2	988	c.498C>G	c.(496-498)ccC>ccG	p.P166P		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GGAATGGAGTGGGCGTTGGCT	0.637000													32	26					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152529166	152529166	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr2:152529166G>A	ENST00000397345.3	-	37	4218	c.4016C>T	c.(4015-4017)tCa>tTa	p.S1339L	NEB_ENST00000172853.10_Missense_Mutation_p.S1339L|NEB_ENST00000604864.1_Missense_Mutation_p.S1339L|NEB_ENST00000409198.1_Missense_Mutation_p.S1339L|NEB_ENST00000427231.2_Missense_Mutation_p.S1339L|NEB_ENST00000603639.1_Missense_Mutation_p.S1339L	NM_001164508.1	NP_001157980	P20929	NEBU_HUMAN	nebulin	1339					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTTTCCCTTTGACTTCTCATA	0.433000													52	59					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664141	22664141	+	RNA	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr22:22664141G>A	ENST00000426066.1	+	0	664					NR_027293.1																						AAATTTGAAGGTGCTGTGATT	0.448000													3	46					0	0	1	0	0
ZNF317	57693	broad.mit.edu	37	19	9271945	9271945	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:9271945G>C	ENST00000247956.6	+	7	1929	c.1624G>C	c.(1624-1626)Ggc>Cgc	p.G542R	ZNF317_ENST00000360385.3_Missense_Mutation_p.G510R	NM_020933.4	NP_065984.3	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	542					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	27						CTTCAGCATAGGCTCCAACCT	0.582000													28	50					0	0	1	0	0
TM9SF2	9375	broad.mit.edu	37	13	100172354	100172354	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr13:100172354G>A	ENST00000376387.4	+	3	494	c.304G>A	c.(304-306)Ggg>Agg	p.G102R	TM9SF2_ENST00000463709.1_3'UTR	NM_004800.1	NP_004791.1	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2	102					transport	endosome membrane|integral to plasma membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)	17	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					GGTACTATTCGGGGAAAGAAT	0.323000													31	59					0	0	1	0	0
RAB10	10890	broad.mit.edu	37	2	26332692	26332692	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr2:26332692G>T	ENST00000264710.4	+	3	743	c.244G>T	c.(244-246)Gca>Tca	p.A82S	RAB10_ENST00000462003.1_3'UTR	NM_016131.4	NP_057215.3	P61026	RAB10_HUMAN	RAB10, member RAS oncogene family	82					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTACAGAGGCGCAATGGGTAT	0.388000													4	75					0.150653	0.150653	1	1	0
GPR114	221188	broad.mit.edu	37	16	57608752	57608752	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr16:57608752C>T	ENST00000340339.4	+	11	1757	c.1234C>T	c.(1234-1236)Cac>Tac	p.H412Y	GPR114_ENST00000349457.3_Missense_Mutation_p.H412Y|GPR114_ENST00000394361.4_3'UTR	NM_153837.1	NP_722579.1	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114	412					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(5)|ovary(2)|stomach(1)|urinary_tract(1)	23						CCCCGTGGTGCACAGTGTCCT	0.701000													7	25					0	0	1	0	0
LTF	4057	broad.mit.edu	37	3	46484998	46484998	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:46484998T>A	ENST00000231751.4	-	13	1884	c.1589A>T	c.(1588-1590)gAg>gTg	p.E530V	LTF_ENST00000417439.1_Missense_Mutation_p.E528V|LTF_ENST00000426532.2_Missense_Mutation_p.E486V	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	530	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	CTCACCCTGCTCGTCGCCAAT	0.537000													11	142					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28493812	28493812	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr6:28493812G>A	ENST00000412168.2	+	1	111	c.22G>A	c.(22-24)Gtc>Atc	p.V8I	GPX6_ENST00000483058.1_Intron|GPX5_ENST00000469384.1_Missense_Mutation_p.V8I	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)	8					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	GTTAAGGGTCGTCCATCTGCT	0.507000													57	175					0	0	1	0	0
DBT	1629	broad.mit.edu	37	1	100661909	100661909	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:100661909C>G	ENST00000370132.4	-	11	1364	c.1351G>C	c.(1351-1353)Gat>Cat	p.D451H		NM_001918.3	NP_001909.3	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase E2						branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(1)	19		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		ACTCTGTGATCAGCTGACCAG	0.353000													41	72					0	0	1	0	0
ART4	420	broad.mit.edu	37	12	14982332	14982332	+	Silent	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr12:14982332G>A	ENST00000228936.4	-	3	1299	c.918C>T	c.(916-918)gtC>gtT	p.V306V	C12orf60_ENST00000527783.1_Intron	NM_021071.2	NP_066549.2	Q93070	NAR4_HUMAN	ADP-ribosyltransferase 4	306					arginine metabolic process|protein ADP-ribosylation	anchored to membrane|plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			large_intestine(5)|liver(1)|lung(3)|prostate(1)|skin(2)|stomach(3)	15						AAAAGATGATGACACTGGTCA	0.313000													24	17					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61830486	61830486	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr10:61830486T>C	ENST00000280772.2	-	37	10344	c.10153A>G	c.(10153-10155)Aat>Gat	p.N3385D	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTGTTCCCATTCTGGGCAATT	0.458000													15	77					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64676294	64676294	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr14:64676294G>A	ENST00000357395.3	+	103	18837	c.7693G>A	c.(7693-7695)Gag>Aag	p.E2565K	SYNE2_ENST00000555022.1_Missense_Mutation_p.E58K|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000554805.1_5'UTR|SYNE2_ENST00000358025.3_Missense_Mutation_p.E6180K|SYNE2_ENST00000394768.2_Missense_Mutation_p.E2565K|SYNE2_ENST00000554584.1_Missense_Mutation_p.E6142K|SYNE2_ENST00000344113.4_Missense_Mutation_p.E6180K|SYNE2_ENST00000555002.1_Missense_Mutation_p.E2814K			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6180					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GAAGAGGTTTGAGGTAAACAC	0.542000													15	17					0	0	1	0	0
SCARA5	286133	broad.mit.edu	37	8	27737193	27737193	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr8:27737193C>A	ENST00000354914.3	-	8	1729	c.1244G>T	c.(1243-1245)gGc>gTc	p.G415V	SCARA5_ENST00000380385.2_Missense_Mutation_p.G190V	NM_173833.5	NP_776194.2	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5 (putative)	415	SRCR.				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|large_intestine(6)|lung(5)|prostate(3)|skin(3)	18		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		ACACACGGTGCCCCAACGCCG	0.667000													4	31					5.50884e-06	6.00587e-06	1	1	0
DNMT1	1786	broad.mit.edu	37	19	10262140	10262140	+	Silent	SNP	T	T	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:10262140T>C	ENST00000340748.4	-	23	2386	c.2151A>G	c.(2149-2151)aaA>aaG	p.K717K	DNMT1_ENST00000359526.4_Silent_p.K733K|DNMT1_ENST00000540357.1_Silent_p.K717K			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	717					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CCTGGTGCATTTTTTTGGGTG	0.507000													16	133					0	0	1	0	0
CHERP	10523	broad.mit.edu	37	19	16634037	16634037	+	Silent	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:16634037C>T	ENST00000546361.2	-	11	1957	c.1806G>A	c.(1804-1806)ccG>ccA	p.P602P	CTD-3222D19.2_ENST00000409035.1_Intron|CHERP_ENST00000544299.1_5'UTR|CHERP_ENST00000198939.6_Silent_p.P613P	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	602	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						CAGCCCAAGGCGGGTGCTCGT	0.662000													16	71					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5141671	5141671	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr4:5141671A>G	ENST00000282908.5	+	2	514	c.92A>G	c.(91-93)aAa>aGa	p.K31R	STK32B_ENST00000510398.1_5'UTR|STK32B_ENST00000512636.1_5'UTR	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	31	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						GCCATTGGTAAAGGGAGTTTT	0.408000													9	124					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20795130	20795130	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr7:20795130C>A	ENST00000404938.2	+	28	4309	c.3657C>A	c.(3655-3657)aaC>aaA	p.N1219K	ABCB5_ENST00000258738.6_Missense_Mutation_p.N774K	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	774					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity	p.N774N(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						CAATTCAGAACGCAGATTTGA	0.448000													15	43					6.31663e-08	7.10008e-08	1	1	0
ATXN7L2	127002	broad.mit.edu	37	1	110032990	110032990	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:110032990G>A	ENST00000369870.3	+	9	1349	c.1334G>A	c.(1333-1335)cGg>cAg	p.R445Q		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	445										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		ATGCTGGAACGGCACCTCAGC	0.542000											OREG0013635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	52					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149885101	149885101	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:149885101A>G	ENST00000369146.3	-	2	782	c.292T>C	c.(292-294)Tat>Cat	p.Y98H	SV2A_ENST00000369145.1_Missense_Mutation_p.Y98H	NM_001278719.1|NM_014849.3	NP_001265648.1|NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	98					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	ATGCCCTGATATTCCCCTTCA	0.597000													41	67					0	0	1	0	0
DAZL	1618	broad.mit.edu	37	3	16640099	16640099	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:16640099C>T	ENST00000250863.8	-	2	357	c.70G>A	c.(70-72)Gca>Aca	p.A24T	DAZL_ENST00000399444.2_Missense_Mutation_p.A4T	NM_001190811.1	NP_001177740.1	Q92904	DAZL_HUMAN	deleted in azoospermia-like	4					germ cell development|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding|translation activator activity		RAF1/DAZL(2)	endometrium(1)|large_intestine(3)|lung(4)|prostate(3)	11						TCAGGATTTGCAGTAGACTGT	0.353000													39	168					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34101011	34101011	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr6:34101011C>T	ENST00000538487.2	-	2	706	c.263G>A	c.(262-264)cGc>cAc	p.R88H	GRM4_ENST00000374177.3_Intron|GRM4_ENST00000374181.4_Missense_Mutation_p.R88H	NM_000841.2|NM_001256811.1	NP_000832.1|NP_001243740.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4						activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	GTTGTTGATGCGATCCAGGGC	0.632000													10	28					0	0	1	0	0
DOK2	9046	broad.mit.edu	37	8	21767264	21767264	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr8:21767264C>A	ENST00000276420.4	-	5	1055	c.797G>T	c.(796-798)cGg>cTg	p.R266L	DOK2_ENST00000544659.1_Missense_Mutation_p.R112L	NM_003974.2	NP_003965.2	O60496	DOK2_HUMAN	docking protein 2, 56kDa	266	Pro-rich.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(3)|skin(1)	26				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GCTATCAGGCCGGGGCAGCGA	0.667000													4	39					0.00909568	0.00928784	1	1	0
EDEM2	55741	broad.mit.edu	37	20	33719490	33719490	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr20:33719490C>T	ENST00000540582.1	-	11	1397	c.676G>A	c.(676-678)Gga>Aga	p.G226R	EDEM2_ENST00000541621.1_Missense_Mutation_p.G46R|EDEM2_ENST00000374491.3_Missense_Mutation_p.G230R|EDEM2_ENST00000374492.3_Missense_Mutation_p.G267R|EDEM2_ENST00000542871.1_5'UTR			Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like 2	267					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	22			BRCA - Breast invasive adenocarcinoma(18;0.00936)			AGGATGGCTCCTTTCACCAAG	0.522000													69	145					0	0	1	0	0
PTK2	5747	broad.mit.edu	37	8	141685581	141685581	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr8:141685581T>C	ENST00000522684.1	-	28	2809	c.2580A>G	c.(2578-2580)atA>atG	p.I860M	PTK2_ENST00000521059.1_Missense_Mutation_p.I860M|PTK2_ENST00000430260.2_Missense_Mutation_p.I170M|PTK2_ENST00000395218.2_Missense_Mutation_p.I860M|PTK2_ENST00000538769.1_Missense_Mutation_p.I528M|PTK2_ENST00000519465.1_Missense_Mutation_p.I488M|PTK2_ENST00000517887.1_Missense_Mutation_p.I904M|PTK2_ENST00000535192.1_Missense_Mutation_p.I814M|PTK2_ENST00000340930.3_Missense_Mutation_p.I860M|PTK2_ENST00000519419.1_Missense_Mutation_p.I904M	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	860	Interaction with TGFB1I1.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			CAGGCTGATATATATGTTGGT	0.403000													22	23					0	0	1	0	0
PLSCR2	57047	broad.mit.edu	37	3	146171928	146171928	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:146171928C>A	ENST00000497985.1	-	7	1002	c.563G>T	c.(562-564)gGt>gTt	p.G188V	PLSCR2_ENST00000336685.2_Missense_Mutation_p.G115V	NM_001199978.1	NP_001186907.1	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	115					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity			endometrium(2)|large_intestine(5)|lung(7)|stomach(1)	15						TACTGGTACACCAGGAGGAGC	0.323000													6	48					5.9392e-07	6.52412e-07	1	1	0
RBM15	64783	broad.mit.edu	37	1	110888973	110888973	+	Silent	SNP	C	C	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:110888973C>G	ENST00000487146.2	+	2	2990	c.2907C>G	c.(2905-2907)ctC>ctG	p.L969L	RBM15_ENST00000369784.3_3'UTR	NM_001201545.1	NP_001188474.1	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	0					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		ATTCAAAGCTCTAATGGACCT	0.363000			T	MKL1	acute megakaryocytic leukemia								21	125					0	0	1	0	0
GLRA1	2741	broad.mit.edu	37	5	151202341	151202341	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr5:151202341T>G	ENST00000274576.4	-	9	1535	c.1243A>C	c.(1243-1245)Atc>Ctc	p.I415L	GLRA1_ENST00000545569.1_Missense_Mutation_p.I332L|GLRA1_ENST00000455880.2_Missense_Mutation_p.I423L	NM_000171.3|NM_001146040.1	NP_000162.2|NP_001139512.1	P23415	GLRA1_HUMAN	glycine receptor, alpha 1	423					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ATTTTGTCGATCTTCTTGGCC	0.502000													23	20					0	0	1	0	0
NADSYN1	55191	broad.mit.edu	37	11	71193919	71193919	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr11:71193919G>A	ENST00000319023.2	+	14	1363	c.1175G>A	c.(1174-1176)cGc>cAc	p.R392H	NADSYN1_ENST00000539574.1_Missense_Mutation_p.R132H|NADSYN1_ENST00000526039.2_3'UTR|NADSYN1_ENST00000530055.1_Missense_Mutation_p.R21H	NM_018161.4	NP_060631.2	Q6IA69	NADE_HUMAN	NAD synthetase 1	392	Ligase (By similarity).				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	25					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCTGATGTCCGCACCATCGTG	0.557000													5	20					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48603971	48603971	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:48603971C>T	ENST00000328333.8	-	112	8437	c.8330G>A	c.(8329-8331)cGa>cAa	p.R2777Q	COL7A1_ENST00000454817.1_Missense_Mutation_p.R2745Q	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2777	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTTCTCGCCTCGAGGACCGGC	0.667000													32	88					0	0	1	0	0
SPATA31D4	389761	broad.mit.edu	37	9	84549711	84549711	+	RNA	SNP	C	C	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr9:84549711C>G	ENST00000585776.1	-	0	1039				SPATA31D4_ENST00000341875.4_RNA																							TGTGCCACATCTAAACCCCAC	0.502000													5	5					0	0	1	0	0
DUSP4	1846	broad.mit.edu	37	8	29202944	29202944	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr8:29202944C>A	ENST00000240101.2	-	2	1662	c.103G>T	c.(103-105)Gcg>Tcg	p.A35S	DUSP4_ENST00000240100.2_Intron	NM_057158.3	NP_476499.1	Q13115	DUS4_HUMAN	dual specificity phosphatase 4	219					endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			endometrium(1)|large_intestine(1)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		ACACCTAACGCCATGCTGGGG	0.512000													12	28					2.27111e-07	2.53316e-07	1	1	0
HNRNPF	3185	broad.mit.edu	37	10	43882861	43882861	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr10:43882861G>C	ENST00000443950.2	-	3	958	c.472C>G	c.(472-474)Cag>Gag	p.Q158E	HNRNPF_ENST00000337970.3_Missense_Mutation_p.Q158E|HNRNPF_ENST00000544000.1_Missense_Mutation_p.Q158E|HNRNPF_ENST00000356053.3_Missense_Mutation_p.Q158E|HNRNPF_ENST00000357065.4_Missense_Mutation_p.Q158E	NM_001098208.1	NP_001091678.1	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	158	RRM 2.				regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|urinary_tract(1)	19						GAGGCAAACTGCACGAACGCT	0.507000													10	112					0	0	1	0	0
KANK2	25959	broad.mit.edu	37	19	11280572	11280572	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:11280572C>T	ENST00000432929.2	-	12	2867	c.2507G>A	c.(2506-2508)cGc>cAc	p.R836H	KANK2_ENST00000589894.1_Missense_Mutation_p.R828H|KANK2_ENST00000587317.1_5'UTR|KANK2_ENST00000355150.5_Missense_Mutation_p.R828H|KANK2_ENST00000589359.1_Missense_Mutation_p.R836H|KANK2_ENST00000586659.1_Missense_Mutation_p.R828H	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	828										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GATGTTCATGCGGGAATACAG	0.532000													8	41					0	0	1	0	0
DCAF13	25879	broad.mit.edu	37	8	104444893	104444893	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr8:104444893T>G	ENST00000297579.5	+	7	1442	c.1165T>G	c.(1165-1167)Tta>Gta	p.L389V	DCAF13_ENST00000521999.1_3'UTR	NM_015420.6	NP_056235.4	Q9NV06	DCA13_HUMAN	DDB1 and CUL4 associated factor 13	237					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						TCAGGTTATCTTAGATATGAG	0.323000													6	112					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61308157	61308157	+	Silent	SNP	T	T	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr18:61308157T>C	ENST00000341074.5	-	5	535	c.420A>G	c.(418-420)ccA>ccG	p.P140P	SERPINB4_ENST00000356424.6_Silent_p.P140P	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						GACTTTCTTCTGGAGCATTTG	0.393000													13	28					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8995649	8995649	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:8995649A>G	ENST00000397910.4	-	63	41542	c.41339T>C	c.(41338-41340)aTa>aCa	p.I13780T	MUC16_ENST00000380951.5_Missense_Mutation_p.I421T	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13782				Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGGCCAAATATCGAGGCTGG	0.458000													3	39					0	0	1	0	0
HIST1H3F	8968	broad.mit.edu	37	6	26250823	26250823	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr6:26250823G>C	ENST00000446824.2	-	1	12	c.11C>G	c.(10-12)aCg>aGg	p.T4R		NM_021018.2	NP_066298.1	P68431	H31_HUMAN	histone cluster 1, H3f	4					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			lung(6)|urinary_tract(1)	7						TGTTTGCTTCGTGCGTGCCAT	0.532000													10	62					0	0	1	0	0
PDIK1L	149420	broad.mit.edu	37	1	26448474	26448474	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:26448474C>A	ENST00000374271.4	+	4	719	c.432C>A	c.(430-432)ttC>ttA	p.F144L	PDIK1L_ENST00000374269.1_Missense_Mutation_p.F144L	NM_001243532.1|NM_001243533.1|NM_152835.4	NP_001230461.1|NP_001230462.1|NP_690048.1	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	144	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity			large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	7		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		ACACCAGCTTCATGCTTCAGC	0.438000													27	87					9.86323e-18	1.17227e-17	1	1	0
NAALADL1	10004	broad.mit.edu	37	11	64825410	64825410	+	Silent	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr11:64825410C>A	ENST00000358658.3	-	3	444	c.417G>T	c.(415-417)ggG>ggT	p.G139G	NAALADL1_ENST00000355369.2_Silent_p.G139G|NAALADL1_ENST00000355721.3_Silent_p.G139G|NAALADL1_ENST00000340252.4_Silent_p.G139G|NAALADL1_ENST00000356632.3_Silent_p.G139G|NAALADL1_ENST00000339885.2_Silent_p.G139G	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	139					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						CCCCTTGCTCCCCGGTCACGT	0.647000													56	40					6.3237e-29	7.57799e-29	1	1	0
TLR4	7099	broad.mit.edu	37	9	120475132	120475132	+	Silent	SNP	A	A	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr9:120475132A>G	ENST00000355622.6	+	3	827	c.726A>G	c.(724-726)gtA>gtG	p.V242V	TLR4_ENST00000394487.4_Silent_p.V202V|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	242					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						GTTTAAATGTAATGAAAACTT	0.348000													10	62					0	0	1	0	0
MAP2K3	5606	broad.mit.edu	37	17	21205510	21205510	+	Missense_Mutation	SNP	G	G	A	rs148304866		TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr17:21205510G>A	ENST00000342679.4	+	6	704	c.455G>A	c.(454-456)cGg>cAg	p.R152Q	MAP2K3_ENST00000361818.5_Missense_Mutation_p.R123Q|MAP2K3_ENST00000316920.6_Missense_Mutation_p.R123Q	NM_145109.2	NP_659731.1	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	152	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity								COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		AAGTTCTACCGGAAGGTGCTG	0.592000													5	22					0	0	1	0	0
IFNE	338376	broad.mit.edu	37	9	21481316	21481316	+	Silent	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr9:21481316C>T	ENST00000448696.3	-	1	996	c.378G>A	c.(376-378)ctG>ctA	p.L126L	MIR31HG_ENST00000304425.3_RNA	NM_176891.4	NP_795372.1	Q86WN2	IFNE_HUMAN	interferon, epsilon	126					defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			large_intestine(2)|lung(1)|skin(1)	4						TCTCTGCTTCCAGTCCCATGA	0.423000													18	168					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158735786	158735786	+	Silent	SNP	G	G	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:158735786G>T	ENST00000335094.2	-	1	706	c.687C>A	c.(685-687)ccC>ccA	p.P229P		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					CGGCAGCTGAGGGAATTCTGA	0.498000													13	98					0.0135373	0.0137266	1	1	0
BUB3	9184	broad.mit.edu	37	10	124922314	124922314	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr10:124922314G>T	ENST00000368865.4	+	7	1150	c.941G>T	c.(940-942)cGc>cTc	p.R314L	BUB3_ENST00000368859.2_Intron|BUB3_ENST00000368858.5_Missense_Mutation_p.R314L|BUB3_ENST00000538238.1_Missense_Mutation_p.R234L|BUB3_ENST00000481952.1_3'UTR	NM_004725.3	NP_004716.1	O43684	BUB3_HUMAN	BUB3 mitotic checkpoint protein	314					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|attachment of spindle microtubules to kinetochore|cell division|meiosis|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	condensed chromosome kinetochore|cytosol|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	9		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)				ATCTTCATTCGCCAAGTGACA	0.383000													11	40					0.000673444	0.000712769	1	1	0
LTF	4057	broad.mit.edu	37	3	46497361	46497361	+	Missense_Mutation	SNP	C	C	T	rs150810057		TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:46497361C>T	ENST00000231751.4	-	4	719	c.424G>A	c.(424-426)Gct>Act	p.A142T	LTF_ENST00000417439.1_Missense_Mutation_p.A142T|LTF_ENST00000426532.2_Missense_Mutation_p.A98T	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	142	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	TTCCATCCAGCGGTCCTGCGA	0.547000													4	60					0	0	1	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118352043	118352043	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr10:118352043A>G	ENST00000528052.1	+	4	391	c.320A>G	c.(319-321)gAc>gGc	p.D107G	PNLIPRP1_ENST00000480870.2_3'UTR|PNLIPRP1_ENST00000442761.1_Missense_Mutation_p.D107G|PNLIPRP1_ENST00000358834.4_Missense_Mutation_p.D107G|PNLIPRP1_ENST00000534537.1_Missense_Mutation_p.D107G			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	107					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		TGGGTGACAGACATGTGCAAG	0.463000													3	21					0	0	1	0	0
SCARA5	286133	broad.mit.edu	37	8	27737194	27737194	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr8:27737194C>T	ENST00000354914.3	-	8	1728	c.1243G>A	c.(1243-1245)Ggc>Agc	p.G415S	SCARA5_ENST00000380385.2_Missense_Mutation_p.G190S	NM_173833.5	NP_776194.2	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5 (putative)	415	SRCR.				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|large_intestine(6)|lung(5)|prostate(3)|skin(3)	18		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CACACGGTGCCCCAACGCCGG	0.662000													4	30					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24463709	24463709	+	Silent	SNP	C	C	T	rs142566825	by1000genomes	TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:24463709C>T	ENST00000270800.1	-	3	305	c.267G>A	c.(265-267)acG>acA	p.T89T		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	89	Fibronectin type-III 1.					integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		AGTAGAGCTCCGTGAGGTTGC	0.612000													6	47					0	0	1	0	0
MOB3C	148932	broad.mit.edu	37	1	47078823	47078823	+	Silent	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:47078823G>A	ENST00000371940.1	-	1	3314	c.240C>T	c.(238-240)gaC>gaT	p.D80D	MOB3C_ENST00000319928.3_Silent_p.D57D|MKNK1_ENST00000545730.1_Intron|MOB3C_ENST00000271139.8_Silent_p.D109D|MOB3C_ENST00000477318.1_5'UTR			Q70IA8	MOL2C_HUMAN	MOB kinase activator 3C	57							metal ion binding										CGATCCAGTCGTCGATGTTCT	0.612000													11	31					0	0	1	0	0
OR5B2	390190	broad.mit.edu	37	11	58190423	58190423	+	Silent	SNP	G	G	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr11:58190423G>C	ENST00000302581.2	-	1	363	c.312C>G	c.(310-312)gcC>gcG	p.A104A		NM_001005566.2	NP_001005566.1	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B, member 2	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CCGTGGCCAAGGCTACAAAGA	0.517000													46	31					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74091848	74091848	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr18:74091848C>A	ENST00000443185.2	-	4	2539	c.2222G>T	c.(2221-2223)cGg>cTg	p.R741L	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	741					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GGGGTCATCCCGCGTCGACCT	0.597000													12	36					6.42651e-13	7.45475e-13	1	1	0
CNTN6	27255	broad.mit.edu	37	3	1363411	1363411	+	Missense_Mutation	SNP	C	C	A	rs148406106		TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:1363411C>A	ENST00000446702.2	+	8	1466	c.839C>A	c.(838-840)gCt>gAt	p.A280D	CNTN6_ENST00000350110.2_Missense_Mutation_p.A280D|CNTN6_ENST00000539053.1_Missense_Mutation_p.A208D			Q9UQ52	CNTN6_HUMAN	contactin 6	280	Ig-like C2-type 3.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAATCCCAAGCTATCCTTGAA	0.458000													18	199					2.35188e-11	2.70653e-11	1	1	0
FAT1	2195	broad.mit.edu	37	4	187630308	187630308	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr4:187630308G>A	ENST00000441802.2	-	2	883	c.674C>T	c.(673-675)gCg>gTg	p.A225V		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	225	Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GCCACGGTCCGCAGCGAGGAT	0.488000										HNSCC(5;0.00058)			3	55					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974406	49974406	+	Silent	SNP	A	A	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr11:49974406A>G	ENST00000555099.1	+	1	464	c.432A>G	c.(430-432)ggA>ggG	p.G144G		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						TGCTAGTGGGAGTGTCATGGG	0.458000													14	51					0	0	1	0	0
DGAT1	8694	broad.mit.edu	37	8	145540729	145540729	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr8:145540729T>A	ENST00000332324.4	-	15	1477	c.1204A>T	c.(1204-1206)Atg>Ttg	p.M402L	DGAT1_ENST00000527438.1_5'UTR	NM_012079.4	NP_036211.2	O75907	DGAT1_HUMAN	diacylglycerol O-acyltransferase 1	402					triglyceride biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	9	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;7.67e-40)|all cancers(56;7.88e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			GTCCTGGCCATCCACTTGCTG	0.607000													8	42					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42531812	42531812	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr18:42531812C>A	ENST00000282030.5	+	4	2803	c.2507C>A	c.(2506-2508)gCc>gAc	p.A836D		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	836						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		AGACTGATGGCCAACTCCCCT	0.542000									Schinzel-Giedion syndrome				7	65					0.00198382	0.00205467	1	1	0
BDKRB2	624	broad.mit.edu	37	14	96707837	96707837	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr14:96707837A>T	ENST00000542454.2	+	3	4179	c.1091A>T	c.(1090-1092)cAg>cTg	p.Q364L	BDKRB2_ENST00000306005.3_Missense_Mutation_p.Q391L|BDKRB2_ENST00000539359.1_Missense_Mutation_p.Q364L|RP11-404P21.8_ENST00000553811.1_Intron|BDKRB2_ENST00000554311.1_Missense_Mutation_p.Q391L			P30411	BKRB2_HUMAN	bradykinin receptor B2	391					arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		GGGAGCAGACAGTGAGCAAAC	0.542000													4	18					0	0	1	0	0
PPM1G	5496	broad.mit.edu	37	2	27604474	27604474	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr2:27604474G>A	ENST00000344034.4	-	10	1897	c.1633C>T	c.(1633-1635)Cga>Tga	p.R545*	PPM1G_ENST00000350803.4_Nonsense_Mutation_p.R545*	NM_177983.2	NP_817092.1	O15355	PPM1G_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1G	545					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					TGCTAGTCTCGCTTGGCCTTC	0.527000													38	128					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108813884	108813884	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:108813884C>G	ENST00000232603.5	-	7	537	c.455G>C	c.(454-456)aGa>aCa	p.R152T	MORC1_ENST00000483760.1_Missense_Mutation_p.R152T	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	152					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTCTCTGGTTCTTATTAACCA	0.299000													14	61					0	0	1	0	0
NKG7	4818	broad.mit.edu	37	19	51875234	51875234	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:51875234G>A	ENST00000595217.1	-	2	545	c.380C>T	c.(379-381)tCt>tTt	p.S127F	NKG7_ENST00000221978.5_Silent_p.F133F|NKG7_ENST00000600427.1_Intron			Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	0						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AGCCCAGGTAGAAGGACCAGG	0.627000													17	68					0	0	1	0	0
ALG13	79868	broad.mit.edu	37	X	111000891	111000891	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chrX:111000891C>T	ENST00000394780.3	+	26	3061	c.3049C>T	c.(3049-3051)Cca>Tca	p.P1017S	ALG13_ENST00000251943.4_Missense_Mutation_p.P834S|ALG13_ENST00000470971.1_3'UTR	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	1017					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|lung(10)|skin(1)	13						AGAGAATTATCCAGTCTATAC	0.478000													12	9					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57754545	57754545	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr17:57754545T>C	ENST00000269122.3	+	17	3066	c.2792T>C	c.(2791-2793)aTt>aCt	p.I931T	CLTC_ENST00000579456.1_Intron|CLTC_ENST00000393043.1_Missense_Mutation_p.I931T	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	931	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CTGGAACTTATTAATGTGAGT	0.403000			T	"""ALK, TFE3"""	"""ALCL, renal """								9	41					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577559	7577559	+	Missense_Mutation	SNP	G	G	A	rs28934573		TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr17:7577559G>A	ENST00000420246.2	-	7	854	c.722C>T	c.(721-723)tCc>tTc	p.S241F	TP53_ENST00000413465.2_Missense_Mutation_p.S241F|TP53_ENST00000445888.2_Missense_Mutation_p.S241F|TP53_ENST00000359597.4_Missense_Mutation_p.S241F|TP53_ENST00000455263.2_Missense_Mutation_p.S241F|TP53_ENST00000269305.4_Missense_Mutation_p.S241F	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	241	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		S -> A (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> F (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934573).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(85)|p.S241C(26)|p.0?(8)|p.S241Y(8)|p.C242fs*5(6)|p.?(5)|p.S241del(5)|p.S148F(4)|p.N239_C242delNSSC(3)|p.N239_C242>S(1)|p.C238fs*21(1)|p.S241fs*22(1)|p.N239_C242del(1)|p.Y236_M243delYMCNSSCM(1)|p.S241_G245delSCMGG(1)|p.S148C(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCATGCAGGAACTGTTACA	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	31					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70065826	70065826	+	RNA	SNP	T	T	C	rs3169319	by1000genomes	TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr16:70065826T>C	ENST00000531894.1	-	0	796					NR_003610.1													p.M209V(4)									GATCCAAACATAGTGTTACAG	0.453000													3	64					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64825411	64825411	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr11:64825411C>A	ENST00000358658.3	-	3	443	c.416G>T	c.(415-417)gGg>gTg	p.G139V	NAALADL1_ENST00000355369.2_Missense_Mutation_p.G139V|NAALADL1_ENST00000355721.3_Missense_Mutation_p.G139V|NAALADL1_ENST00000340252.4_Missense_Mutation_p.G139V|NAALADL1_ENST00000356632.3_Missense_Mutation_p.G139V|NAALADL1_ENST00000339885.2_Missense_Mutation_p.G139V	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	139					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity	p.G139V(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						CCCTTGCTCCCCGGTCACGTT	0.652000													56	41					6.3237e-29	7.57799e-29	1	1	0
ISM2	145501	broad.mit.edu	37	14	77942241	77942241	+	Silent	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr14:77942241C>T	ENST00000393684.3	-	8	1540	c.1149G>A	c.(1147-1149)acG>acA	p.T383T	ISM2_ENST00000429906.1_Silent_p.T390T|ISM2_ENST00000342219.4_Silent_p.T471T|ISM2_ENST00000493585.1_3'UTR|ISM2_ENST00000412904.1_Silent_p.T390T			Q6H9L7	ISM2_HUMAN	isthmin 2	471						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						AGAAGCGCGCCGTGGGCTGGT	0.677000													20	12					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110479730	110479730	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr11:110479730T>G	ENST00000260283.4	-	9	1037	c.753A>C	c.(751-753)gaA>gaC	p.E251D	ARHGAP20_ENST00000524756.1_Missense_Mutation_p.E228D|ARHGAP20_ENST00000528829.1_Missense_Mutation_p.E215D|ARHGAP20_ENST00000533353.1_Missense_Mutation_p.E225D|ARHGAP20_ENST00000527598.1_Missense_Mutation_p.E215D|ARHGAP20_ENST00000357139.3_Missense_Mutation_p.E225D	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	251	Ras-associating.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		ATGGAGCCTCTTCTTTGCCAG	0.348000													21	99					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383415	22383415	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr15:22383415A>G	ENST00000328795.4	+	1	1034	c.943A>G	c.(943-945)Aga>Gga	p.R315G	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	315					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTTTATAATAAGAAACTGAGA	0.393000													6	18					0	0	1	0	0
NOM1	64434	broad.mit.edu	37	7	156755828	156755828	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr7:156755828A>G	ENST00000275820.3	+	6	1885	c.1870A>G	c.(1870-1872)Aac>Gac	p.N624D		NM_138400.1	NP_612409.1	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	624					RNA metabolic process	nucleolus	protein binding			endometrium(5)|kidney(4)|large_intestine(9)|lung(7)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GATGATCGACAACAGTCACCA	0.637000													7	26					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10079123	10079123	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:10079123C>T	ENST00000264828.3	-	59	4337	c.4252G>A	c.(4252-4254)Ggt>Agt	p.G1418S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1418	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CCTTTCTCACCAGCTTCTCCC	0.587000													51	61					0	0	1	0	0
SETD7	80854	broad.mit.edu	37	4	140450200	140450200	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr4:140450200C>G	ENST00000274031.3	-	4	1183	c.547G>C	c.(547-549)Gaa>Caa	p.E183Q	SETD7_ENST00000506866.2_Missense_Mutation_p.E183Q	NM_030648.2	NP_085151.1	Q8WTS6	SETD7_HUMAN	SET domain containing (lysine methyltransferase) 7	183					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	8	all_hematologic(180;0.156)					GGCATCAGTTCAAAGTGAGGC	0.443000													3	82					0	0	1	0	0
FAM124A	220108	broad.mit.edu	37	13	51825996	51825996	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr13:51825996G>A	ENST00000322475.8	+	3	628	c.493G>A	c.(493-495)Gtg>Atg	p.V165M	FAM124A_ENST00000280057.6_Missense_Mutation_p.V201M	NM_001242312.1	NP_001229241.1	Q86V42	F124A_HUMAN	family with sequence similarity 124A	165										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|skin(1)	26		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		CATCCGGCCCGTGCACTACGG	0.637000													7	8					0	0	1	0	0
ABRA	137735	broad.mit.edu	37	8	107782373	107782373	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr8:107782373C>A	ENST00000311955.3	-	1	100	c.46G>T	c.(46-48)Gcc>Tcc	p.A16S		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	16					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			TTCCGGAGGGCGCTCTTGGCT	0.612000													7	92					0.00621372	0.00638999	1	1	0
ROBO1	6091	broad.mit.edu	37	3	78988065	78988065	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:78988065C>T	ENST00000436010.2	-	2	1065	c.68G>A	c.(67-69)cGt>cAt	p.R23H	ROBO1_ENST00000464233.1_Missense_Mutation_p.R62H|ROBO1_ENST00000467549.1_Missense_Mutation_p.R23H|ROBO1_ENST00000495273.1_Missense_Mutation_p.R23H			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	62					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ATCTTCCTGACGAAGACGGGA	0.418000													4	66					0	0	1	0	0
HECTD3	79654	broad.mit.edu	37	1	45473170	45473170	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:45473170C>T	ENST00000372172.4	-	10	1489	c.1418G>A	c.(1417-1419)cGc>cAc	p.R473H	HECTD3_ENST00000372168.3_Missense_Mutation_p.R83H	NM_024602.5	NP_078878.3	Q5T447	HECD3_HUMAN	HECT domain containing E3 ubiquitin protein ligase 3	473					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|stomach(1)	28	Acute lymphoblastic leukemia(166;0.155)					GATGTATAGGCGTGGCATGAA	0.607000													7	57					0	0	1	0	0
AGO3	192669	broad.mit.edu	37	1	36479559	36479559	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:36479559G>A	ENST00000373191.4	+	11	1665	c.1316G>A	c.(1315-1317)cGa>cAa	p.R439Q	AGO3_ENST00000246314.6_Missense_Mutation_p.R205Q	NM_024852.3	NP_079128.2			argonaute RISC catalytic component 3									p.R439Q(1)									TGGGACATGCGAGGGAAACAA	0.408000													14	87					0	0	1	0	0
SLC25A23	79085	broad.mit.edu	37	19	6456534	6456534	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:6456534C>T	ENST00000301454.4	-	4	486	c.380G>A	c.(379-381)cGa>cAa	p.R127Q	SLC25A23_ENST00000334510.5_Missense_Mutation_p.R127Q	NM_024103.2	NP_077008.2	Q9BV35	SCMC3_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	127	EF-hand 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|pancreas(1)|skin(1)	17						TGTGCCGTCTCGGTCCATGCT	0.562000													33	9					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39382886	39382886	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr5:39382886T>C	ENST00000545653.1	-	9	1642	c.1112A>G	c.(1111-1113)aAa>aGa	p.K371R	DAB2_ENST00000509337.1_Missense_Mutation_p.K371R|DAB2_ENST00000320816.6_Missense_Mutation_p.K392R|DAB2_ENST00000339788.6_Intron	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	392					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			CGGGGAGGATTTGACAGAGAA	0.522000													8	79					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214837062	214837062	+	Silent	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:214837062C>T	ENST00000366955.3	+	20	9438	c.9270C>T	c.(9268-9270)gtC>gtT	p.V3090V		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	3186	Sufficient for centromere localization.|Sufficient for nuclear localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GCCTGAGGGTCAAGCGAGGCC	0.567000													7	29					0	0	1	0	0
ITGB3	3690	broad.mit.edu	37	17	45376748	45376748	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr17:45376748C>T	ENST00000559488.1	+	11	1781	c.1765C>T	c.(1765-1767)Cgt>Tgt	p.R589C	ITGB3_ENST00000435993.2_Missense_Mutation_p.R542C|ITGB3_ENST00000560629.1_Missense_Mutation_p.A577V	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	589	Cysteine-rich tandem repeats.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	CTGTACCACGCGTACTGACAC	0.607000													8	92					0	0	1	0	0
DCAF13	25879	broad.mit.edu	37	8	104444895	104444895	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr8:104444895A>T	ENST00000297579.5	+	7	1444	c.1167A>T	c.(1165-1167)ttA>ttT	p.L389F	DCAF13_ENST00000521999.1_3'UTR	NM_015420.6	NP_056235.4	Q9NV06	DCA13_HUMAN	DDB1 and CUL4 associated factor 13	237					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						AGGTTATCTTAGATATGAGAA	0.328000													6	119					0	0	1	0	0
ATAD2B	54454	broad.mit.edu	37	2	24056803	24056803	+	Silent	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr2:24056803G>A	ENST00000238789.5	-	14	2057	c.1714C>T	c.(1714-1716)Ctg>Ttg	p.L572L		NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	572							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATCAGGCAGGTTGAAGAGG	0.353000													3	40					0	0	1	0	0
SLC25A6	293	broad.mit.edu	37	X	1506239	1506239	+	Silent	SNP	G	G	A	rs143974718		TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chrX:1506239G>A	ENST00000381401.5	-	3	1386	c.672C>T	c.(670-672)gcC>gcT	p.A224A	SLC25A6_ENST00000475167.1_5'UTR	NM_001636.3	NP_001627.2	P12236	ADT3_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	224					active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|upper_aerodigestive_tract(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	ACACCACGCCGGCCACGGCCG	0.692000													21	24					0	0	1	0	0
LRIF1	55791	broad.mit.edu	37	1	111494532	111494532	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:111494532T>C	ENST00000369763.4	-	2	1364	c.974A>G	c.(973-975)aAa>aGa	p.K325R	RP11-96K19.2_ENST00000440689.1_RNA|LRIF1_ENST00000494675.1_Intron|LRIF1_ENST00000485275.2_Intron	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						TCCCAAATTTTTCCTATCTAC	0.338000													9	58					0	0	1	0	0
RTP1	132112	broad.mit.edu	37	3	186915464	186915464	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:186915464T>A	ENST00000312295.4	+	1	191	c.161T>A	c.(160-162)aTg>aAg	p.M54K	RP11-208N14.4_ENST00000356133.3_RNA	NM_153708.2	NP_714919.2	P59025	RTP1_HUMAN	receptor (chemosensory) transporter protein 1	54					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		TATGAGAAGATGGAGGAGGCA	0.502000													8	72					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								5	59					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89799951	89799951	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr16:89799951G>A	ENST00000289816.5	+	8	1429	c.1117G>A	c.(1117-1119)Gct>Act	p.A373T	ZNF276_ENST00000446326.2_Missense_Mutation_p.A234T|ZNF276_ENST00000443381.2_Missense_Mutation_p.A448T|ZNF276_ENST00000568064.1_Missense_Mutation_p.A356T	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GTACCGAGGCGCTGACGGCAT	0.622000													7	40					0	0	1	0	0
VRK2	7444	broad.mit.edu	37	2	58276000	58276000	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr2:58276000C>T	ENST00000435505.2	+	5	779	c.34C>T	c.(34-36)Cct>Tct	p.P12S	VRK2_ENST00000412104.2_Missense_Mutation_p.P12S|VRK2_ENST00000340157.4_Missense_Mutation_p.P12S|VRK2_ENST00000440705.2_Intron|VRK2_ENST00000417641.2_Missense_Mutation_p.P12S			Q86Y07	VRK2_HUMAN	vaccinia related kinase 2	12						integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	24						ATACAAACTTCCTATTCCATT	0.378000													14	56					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075090	9075090	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:9075090G>T	ENST00000397910.4	-	3	12559	c.12356C>A	c.(12355-12357)aCa>aAa	p.T4119K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4121	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGAGTCCCTGTCCAGGAGGC	0.498000													5	67					0.000602214	0.000642067	1	1	0
OR5T1	390155	broad.mit.edu	37	11	56043951	56043951	+	Silent	SNP	T	T	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr11:56043951T>G	ENST00000313033.2	+	1	923	c.837T>G	c.(835-837)acT>acG	p.T279T		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	279					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T279T(1)		NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					CCAGCTACACTTCGGACAATG	0.413000													13	140					0	0	1	0	0
HIPK3	10114	broad.mit.edu	37	11	33308581	33308581	+	Silent	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr11:33308581G>A	ENST00000303296.4	+	2	926	c.621G>A	c.(619-621)acG>acA	p.T207T	HIPK3_ENST00000456517.1_Silent_p.T207T|HIPK3_ENST00000379016.3_Silent_p.T207T|HIPK3_ENST00000525975.1_Silent_p.T207T	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	207	Protein kinase.				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						GTCGAGGCACGTTTGGCCAGG	0.393000													6	331					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39196714	39196714	+	Missense_Mutation	SNP	G	G	T	rs145839832		TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr6:39196714G>T	ENST00000359534.3	-	1	512	c.174C>A	c.(172-174)gaC>gaA	p.D58E		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	58					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						CTAGGATCTTGTCCAGGCCCT	0.562000													49	100					1.38658e-30	1.68953e-30	1	1	0
ZNF366	167465	broad.mit.edu	37	5	71756827	71756827	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr5:71756827G>T	ENST00000318442.5	-	2	987	c.497C>A	c.(496-498)cCc>cAc	p.P166H		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GAATGGAGTGGGCGTTGGCTG	0.632000													35	26					4.65686e-17	5.4898e-17	1	1	0
DAAM2	23500	broad.mit.edu	37	6	39855301	39855301	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr6:39855301C>T	ENST00000538976.1	+	16	2175	c.1993C>T	c.(1993-1995)Cgc>Tgc	p.R665C	DAAM2_ENST00000398904.2_Missense_Mutation_p.R665C|DAAM2_ENST00000274867.4_Missense_Mutation_p.R665C|RP11-61I13.3_ENST00000607675.1_RNA	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	665	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					CCTGGCTTCCCGCAAGGTCAA	0.517000													3	22					0	0	1	0	0
FETUB	26998	broad.mit.edu	37	3	186370395	186370395	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:186370395C>T	ENST00000265029.3	+	7	1225	c.1124C>T	c.(1123-1125)gCc>gTc	p.A375V	RP11-134F2.2_ENST00000455926.1_RNA|FETUB_ENST00000539949.1_Missense_Mutation_p.A227V|FETUB_ENST00000450521.1_Missense_Mutation_p.A375V|RP11-134F2.2_ENST00000428501.1_RNA|FETUB_ENST00000382134.3_Missense_Mutation_p.A310V|FETUB_ENST00000382136.3_Missense_Mutation_p.A338V	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	375						extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		GCCCAGAATGCCAGCCCTCTT	0.582000													19	35					0	0	1	0	0
SNHG24	101929369	broad.mit.edu	37	14	101434447	101434447	+	RNA	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr14:101434447C>T	ENST00000554693.2	+	0	135				SNORD114-11_ENST00000363738.1_RNA																							AGGGCTGATCCTGGACCAGTG	0.408000													7	16					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54784854	54784854	+	Silent	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chrX:54784854C>T	ENST00000218436.6	-	8	1682	c.1653G>A	c.(1651-1653)gaG>gaA	p.E551E		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	551					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										TGGGGGCTGGCTCCCCTGGGC	0.617000													4	9					0	0	1	0	0
TF	7018	broad.mit.edu	37	3	133467353	133467353	+	Silent	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:133467353C>T	ENST00000402696.3	+	2	626	c.141C>T	c.(139-141)agC>agT	p.S47S	TF_ENST00000264998.3_Intron|TFP1_ENST00000460564.1_RNA|TF_ENST00000475382.1_3'UTR	NM_001063.3	NP_001054	P02787	TRFE_HUMAN	transferrin	47	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	ATATGAAAAGCGTCATTCCAT	0.522000													6	33					0	0	1	0	0
RBM28	55131	broad.mit.edu	37	7	127978360	127978360	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr7:127978360T>C	ENST00000223073.2	-	5	599	c.485A>G	c.(484-486)aAa>aGa	p.K162R	RBM28_ENST00000415472.2_Intron	NM_018077.2	NP_060547.2	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28		RRM 2.				mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			breast(1)|kidney(7)|large_intestine(3)|lung(8)|ovary(2)	21						TAGGAGGTTTTTGAACTGAAC	0.418000													37	90					0	0	1	0	0
MOB3C	148932	broad.mit.edu	37	1	47078624	47078624	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:47078624A>T	ENST00000371940.1	-	1	3513	c.439T>A	c.(439-441)Tgg>Agg	p.W147R	MOB3C_ENST00000319928.3_Missense_Mutation_p.W124R|MKNK1_ENST00000545730.1_Intron|MOB3C_ENST00000271139.8_Missense_Mutation_p.W176R|MOB3C_ENST00000477318.1_5'UTR			Q70IA8	MOL2C_HUMAN	MOB kinase activator 3C	124							metal ion binding										CCTTCGATCCAGTCCATGAGC	0.652000													4	57					0	0	1	0	0
CYTH2	9266	broad.mit.edu	37	19	48973672	48973672	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:48973672G>A	ENST00000427476.1	+	2	382	c.82G>A	c.(82-84)Gag>Aag	p.E28K	CYTH2_ENST00000452733.2_Missense_Mutation_p.E28K|CTC-273B12.7_ENST00000595676.1_Missense_Mutation_p.E12K	NM_004228.6|NM_017457.5	NP_004219.3|NP_059431.1	Q99418	CYH2_HUMAN	cytohesin 2	28					actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						GCGGAAGCAGGAGCTGCTGGT	0.637000													76	65					0	0	1	0	0
SLC12A9	56996	broad.mit.edu	37	7	100456488	100456488	+	Silent	SNP	C	C	T	rs140425277		TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr7:100456488C>T	ENST00000354161.3	+	6	914	c.789C>T	c.(787-789)gcC>gcT	p.A263A	SLC12A9_ENST00000415287.1_Silent_p.A174A|SLC12A9_ENST00000275729.3_Silent_p.A174A|SLC12A9_ENST00000540482.1_Silent_p.A263A|SLC12A9_ENST00000428758.1_Silent_p.A263A	NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9	263						integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					CCACGGGAGCCGTGATGAATT	0.582000													10	60					0	0	1	0	0
ZNF354C	30832	broad.mit.edu	37	5	178506308	178506308	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr5:178506308G>C	ENST00000315475.6	+	5	1181	c.875G>C	c.(874-876)aGa>aCa	p.R292T		NM_014594.1	NP_055409.1	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|urinary_tract(3)	30	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		AAACATCTGAGAGTGCATACT	0.413000													10	87					0	0	1	0	0
PRRG4	79056	broad.mit.edu	37	11	32858222	32858222	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr11:32858222A>C	ENST00000257836.3	+	3	375	c.122A>C	c.(121-123)gAa>gCa	p.E41A		NM_024081.5	NP_076986.1	Q9BZD6	TMG4_HUMAN	proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)	41						extracellular region|Golgi apparatus|integral to membrane	calcium ion binding			large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	7	Breast(20;0.206)					TCAAAAGAAGAAGCAAACTTT	0.318000													119	41					0	0	1	0	0
CYTH2	9266	broad.mit.edu	37	19	48977495	48977495	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:48977495C>T	ENST00000427476.1	+	7	904	c.604C>T	c.(604-606)Ccc>Tcc	p.P202S	CYTH2_ENST00000452733.2_Missense_Mutation_p.P202S	NM_004228.6|NM_017457.5	NP_004219.3|NP_059431.1	Q99418	CYH2_HUMAN	cytohesin 2	202					actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						TCTCCACAATCCCAATGTCCG	0.627000													7	74					0	0	1	0	0
WTIP	126374	broad.mit.edu	37	19	34981329	34981329	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr19:34981329G>T	ENST00000590071.2	+	2	1053	c.716G>T	c.(715-717)tGc>tTc	p.C239F	WTIP_ENST00000270288.6_Missense_Mutation_p.C463F	NM_001080436.1	NP_001073905.1			Wilms tumor 1 interacting protein											NS(1)|large_intestine(2)|lung(1)	4	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			CAGCAGGCGTGCCAGGCAATG	0.592000													8	61					3.09899e-07	3.43017e-07	1	1	0
FMNL2	114793	broad.mit.edu	37	2	153484918	153484918	+	Silent	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr2:153484918G>A	ENST00000288670.9	+	18	2638	c.2271G>A	c.(2269-2271)aaG>aaA	p.K757K	FMNL2_ENST00000475377.2_Silent_p.K132K	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	757	FH2.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						GGGAAAGGAAGCCTCTGGAAA	0.468000													9	73					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95085752	95085752	+	Silent	SNP	A	A	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr14:95085752A>G	ENST00000467132.1	+	3	2012	c.864A>G	c.(862-864)gaA>gaG	p.E288E	SERPINA3_ENST00000393078.3_Silent_p.E288E|RP11-986E7.7_ENST00000553947.1_3'UTR|SERPINA3_ENST00000393080.4_Silent_p.E288E|SERPINA3_ENST00000482740.1_Silent_p.E70E			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	288					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		AGGAAGTGGAAGCCATGCTGC	0.577000													4	26					0	0	1	0	0
COX5A	9377	broad.mit.edu	37	15	75219205	75219205	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr15:75219205C>T	ENST00000322347.6	-	3	394	c.241G>A	c.(241-243)Gat>Aat	p.D81N	COX5A_ENST00000564811.1_Missense_Mutation_p.D81N|COX5A_ENST00000562233.1_Intron|COX5A_ENST00000568783.1_Missense_Mutation_p.D81N|COX5A_ENST00000568517.1_5'UTR|COX5A_ENST00000567270.1_Missense_Mutation_p.D42N	NM_004255.3	NP_004246.2	P20674	COX5A_HUMAN	cytochrome c oxidase subunit Va	81					respiratory electron transport chain	mitochondrial inner membrane	cytochrome-c oxidase activity|electron carrier activity|metal ion binding			endometrium(1)|large_intestine(1)|pancreas(1)	3						GGAACCATATCATAGGTAACA	0.388000													13	50					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158735787	158735787	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:158735787G>T	ENST00000335094.2	-	1	705	c.686C>A	c.(685-687)cCc>cAc	p.P229H		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					GGCAGCTGAGGGAATTCTGAG	0.502000													13	98					0.00185496	0.00194905	1	1	0
MKX	283078	broad.mit.edu	37	10	28030333	28030333	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr10:28030333A>G	ENST00000375790.5	-	3	721	c.289T>C	c.(289-291)Tac>Cac	p.Y97H	MKX_ENST00000419761.1_Missense_Mutation_p.Y97H			Q8IYA7	MKX_HUMAN	mohawk homeobox	97					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						TTGGTGGGGTACGGGTTGTCA	0.602000													12	57					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64636746	64636746	+	Silent	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:64636746G>A	ENST00000498707.1	-	9	1752	c.1410C>T	c.(1408-1410)acC>acT	p.T470T	ADAMTS9_ENST00000295903.4_Silent_p.T442T|ADAMTS9_ENST00000459780.1_Silent_p.T470T	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	470	Peptidase M12B.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TCCAGGGGTTGGTGTAGAAGT	0.408000													30	57					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42531813	42531813	+	Silent	SNP	C	C	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr18:42531813C>A	ENST00000282030.5	+	4	2804	c.2508C>A	c.(2506-2508)gcC>gcA	p.A836A		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	836						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GACTGATGGCCAACTCCCCTT	0.547000									Schinzel-Giedion syndrome				7	65					0.00198382	0.00205467	1	1	0
CDCA7L	55536	broad.mit.edu	37	7	21945172	21945172	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr7:21945172T>A	ENST00000406877.3	-	7	1278	c.999A>T	c.(997-999)ttA>ttT	p.L333F	CDCA7L_ENST00000465490.1_5'UTR|CDCA7L_ENST00000356195.5_Missense_Mutation_p.L299F|CDCA7L_ENST00000373934.4_Missense_Mutation_p.L287F	NM_018719.4	NP_061189.2	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like	333					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	29						CAACATTTTCTAAGTCCTCTT	0.408000													7	172					0	0	1	0	0
RSPO2	340419	broad.mit.edu	37	8	108972946	108972946	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr8:108972946C>T	ENST00000276659.5	-	4	1003	c.383G>A	c.(382-384)tGt>tAt	p.C128Y	RSPO2_ENST00000517781.1_Missense_Mutation_p.C65Y|RSPO2_ENST00000517939.1_Missense_Mutation_p.C61Y|RSPO2_ENST00000378439.2_Missense_Mutation_p.C65Y	NM_178565.4	NP_848660.3	Q6UXX9	RSPO2_HUMAN	R-spondin 2	128					Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			ACCATCTGGACATTCATCAAA	0.373000													8	99					0	0	1	0	0
KLHL28	54813	broad.mit.edu	37	14	45398298	45398298	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr14:45398298G>A	ENST00000396128.4	-	5	1768	c.1649C>T	c.(1648-1650)tCa>tTa	p.S550L	KLHL28_ENST00000355081.2_Missense_Mutation_p.S564L	NM_017658.3	NP_060128.2	Q9NXS3	KLH28_HUMAN	kelch-like family member 28	550										breast(2)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CCACGTATCTGAGATAGGATC	0.448000													27	39					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71346978	71346978	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr4:71346978T>C	ENST00000413702.1	+	4	805	c.517T>C	c.(517-519)Tct>Cct	p.S173P	MUC7_ENST00000514512.1_3'UTR|MUC7_ENST00000456088.1_Missense_Mutation_p.S173P|MUC7_ENST00000304887.5_Missense_Mutation_p.S173P	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	173	Thr-rich.					extracellular region	protein binding	p.S173P(3)		central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.522000													6	157					0	0	1	0	0
NMRK1	54981	broad.mit.edu	37	9	77698025	77698025	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr9:77698025T>G	ENST00000361092.4	-	2	243	c.7A>C	c.(7-9)Aca>Cca	p.T3P	NMRK1_ENST00000376808.4_Missense_Mutation_p.T3P|NMRK1_ENST00000376811.1_5'UTR	NM_017881.2	NP_060351.1	Q9NWW6	NRK1_HUMAN	nicotinamide riboside kinase 1	3					pyridine nucleotide biosynthetic process		ATP binding|metal ion binding|ribosylnicotinamide kinase activity										ATGATAAATGTTTTCATAATT	0.343000													7	31					0	0	1	0	0
DHDDS	79947	broad.mit.edu	37	1	26795524	26795525	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:26795524_26795525delCT	ENST00000360009.2	+	9	984_985	c.907_908delCT	c.(907-909)ctcfs	p.L303fs	DHDDS_ENST00000526219.1_Frame_Shift_Del_p.L263fs|DHDDS_ENST00000236342.7_Frame_Shift_Del_p.L302fs|DHDDS_ENST00000525682.2_Frame_Shift_Del_p.L268fs	NM_024887.3|NM_205861.2	NP_079163.2|NP_995583.1	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase	302							protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(5)|endometrium(2)|large_intestine(2)|lung(4)|stomach(1)|urinary_tract(1)	15		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		CTTGCACAAACTCTCGGCCAGA	0.634													9	41	---	---	---	---					
KCNN3	3782	broad.mit.edu	37	1	154680586	154680588	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:154680586_154680588delGCT	ENST00000271915.4	-	8	2375_2377	c.2060_2062delAGC	c.(2059-2064)cagctc>ctc	p.Q687del	KCNN3_ENST00000515643.1_5'UTR|KCNN3_ENST00000358505.2_In_Frame_Del_p.Q374del|KCNN3_ENST00000361147.4_In_Frame_Del_p.Q382del	NM_001204087.1|NM_002249.5	NP_001191016.1|NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3							integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			GCAGACAGGAGCTGCTGCTGCTG	0.640													8	137	---	---	---	---					
OR2T10	127069	broad.mit.edu	37	1	248756713	248756713	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr1:248756713delG	ENST00000330500.2	-	1	387	c.357delC	c.(355-357)gccfs	p.A119fs		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	119					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGCGGTCATAGGCCATGGCGG	0.562													2	4	---	---	---	---					
CD96	10225	broad.mit.edu	37	3	111197863	111197870	+	RNA	DEL	CACACACA	CACACACA	-	rs71968470		TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr3:111197863_111197870delCACACACA	ENST00000497896.1	-	0	208																											CGAACAGCCTcacacacacacacacaca	0.543													2	4	---	---	---	---					
FAM115C	285966	broad.mit.edu	37	7	143417404	143417405	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr7:143417404_143417405delCT	ENST00000441159.2	+	3	1318_1319	c.1252_1253delCT	c.(1252-1254)ctcfs	p.L418fs	FAM115C_ENST00000357344.4_Frame_Shift_Del_p.L418fs|FAM115C_ENST00000444908.2_Frame_Shift_Del_p.L418fs|FAM115C_ENST00000425618.2_Frame_Shift_Del_p.L137fs|FAM115C_ENST00000409703.3_Frame_Shift_Del_p.L254fs|FAM115C_ENST00000411935.1_Frame_Shift_Del_p.L254fs|FAM115C_ENST00000411497.2_Frame_Shift_Del_p.L137fs			A6NFQ2	F115C_HUMAN	family with sequence similarity 115, member C	418										endometrium(2)|large_intestine(4)|lung(2)|prostate(1)	9						CCGCAAGGCGCTCTCTCAATTC	0.530													5	6	---	---	---	---					
ZC3H3	23144	broad.mit.edu	37	8	144522387	144522389	+	In_Frame_Del	DEL	GAG	GAG	-	rs2272753	byFrequency	TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr8:144522387_144522389delGAG	ENST00000262577.5	-	11	2668_2670	c.2637_2639delCTC	c.(2635-2640)tcctca>tca	p.879_880SS>S		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	879	Poly-Ser.				mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			Gggaggggatgaggaggaggagg	0.655													2	4	---	---	---	---					
OVOS2	144203	broad.mit.edu	37	12	31269189	31269190	+	RNA	INS	-	-	ATCAT	rs35880498		TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr12:31269189_31269190insATCAT	ENST00000542490.1	-	0	165																				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(25)|prostate(3)|stomach(3)|urinary_tract(1)	41						CATGAGAACTCATTACCATGAT	0.351													2	4	---	---	---	---					
RB1	5925	broad.mit.edu	37	13	48954344	48954345	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr13:48954344_48954345insGC	ENST00000267163.4	+	16	1603_1604	c.1465_1466insGC	c.(1465-1467)tgcfs	p.C489fs		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	489	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(8)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTTATTGGCGTGCGCTCTTGAG	0.267		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			15	30	---	---	---	---					
DMXL2	23312	broad.mit.edu	37	15	51791053	51791054	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr15:51791053_51791054insT	ENST00000251076.5	-	18	4654_4655	c.4367_4368insA	c.(4366-4368)tatfs	p.Y1456fs	DMXL2_ENST00000543779.2_Frame_Shift_Ins_p.Y1456fs|DMXL2_ENST00000449909.3_Intron	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1456						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		TCTGATCTTCATAGCTCTGTGG	0.386													13	90	---	---	---	---					
HSD3B7	80270	broad.mit.edu	37	16	30997024	30997025	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr16:30997024_30997025delAG	ENST00000262520.6	+	2	335_336	c.45_46delAG	c.(43-48)acagggfs	p.G17fs	HSD3B7_ENST00000297679.5_Frame_Shift_Del_p.G17fs|HSD3B7_ENST00000353250.5_Frame_Shift_Del_p.G17fs|AC135048.1_ENST00000602217.1_Frame_Shift_Del_p.P170fs	NM_001142777.1	NP_001136249.1	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	17					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						ACCTGGTCACAGGGGGCTGTGG	0.663													4	7	---	---	---	---					
KAT7	11143	broad.mit.edu	37	17	47895328	47895329	+	Frame_Shift_Ins	INS	-	-	TGTT			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr17:47895328_47895329insTGTT	ENST00000503935.2	+	9	1678_1679	c.642_643insTGTT	c.(643-645)tgtfs	p.-216fs	KAT7_ENST00000259021.4_Frame_Shift_Ins_p.-372fs|KAT7_ENST00000513980.1_Intron|KAT7_ENST00000424009.2_Frame_Shift_Ins_p.-342fs|KAT7_ENST00000509773.1_Frame_Shift_Ins_p.-262fs|KAT7_ENST00000435742.2_Frame_Shift_Ins_p.-186fs|KAT7_ENST00000510819.1_Frame_Shift_Ins_p.-203fs|KAT7_ENST00000454930.2_Frame_Shift_Ins_p.-233fs			O95251	MYST2_HUMAN	K(lysine) acetyltransferase 7						DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding										TGTGTGAATTCTGTTTAAAATA	0.436													30	57	---	---	---	---					
TYMP	1890	broad.mit.edu	37	22	50968108	50968108	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chr22:50968108delC	ENST00000252029.3	-	2	193	c.31delG	c.(31-33)gccfs	p.A11fs	TYMP_ENST00000395680.1_Frame_Shift_Del_p.A11fs|TYMP_ENST00000395681.1_Frame_Shift_Del_p.A11fs|TYMP_ENST00000395678.3_Frame_Shift_Del_p.A11fs	NM_001113755.2|NM_001113756.2|NM_001257988.1|NM_001257989.1|NM_001953.4	NP_001107227.1|NP_001107228.1|NP_001244917.1|NP_001244918.1|NP_001944.1	P19971	TYPH_HUMAN	thymidine phosphorylase	11					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			large_intestine(1)|lung(2)|ovary(1)|prostate(1)	5		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	GCGGGTGGGGCCCCGGTTCCC	0.711													2	4	---	---	---	---					
POF1B	79983	broad.mit.edu	37	X	84634288	84634289	+	Frame_Shift_Ins	INS	-	-	C			TCGA-ZF-AA4T-01A-11D-A38G-08	TCGA-ZF-AA4T-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3804bc-d4c2-479c-9e1c-59f45b0e21f9	8ca994d3-3bce-4f10-9f39-9374f8b10915	g.chrX:84634288_84634289insC	ENST00000262753.4	-	2	316_317	c.171_172insG	c.(169-174)gggcccfs	p.P58fs	POF1B_ENST00000373145.3_Frame_Shift_Ins_p.P58fs	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	58							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TTGTTCATGGGCCCACTGTAGG	0.540													7	32	---	---	---	---					
