Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CCDC94	55702	broad.mit.edu	37	19	4247149	4247149	+	Silent	SNP	G	G	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr19:4247149G>T	ENST00000262962.7	+	1	74	c.6G>T	c.(4-6)tcG>tcT	p.S2S		NM_018074.4	NP_060544.2	Q9BW85	CCD94_HUMAN	coiled-coil domain containing 94	2										NS(1)|endometrium(1)|lung(2)|ovary(1)|stomach(2)	7				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0348)|STAD - Stomach adenocarcinoma(1328;0.183)		CAAAGATGTCGGAGCGAAAAG	0.517000											OREG0025163	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	54					2.48551e-13	2.72604e-13	1	1	0
USP31	57478	broad.mit.edu	37	16	23098411	23098411	+	Splice_Site	SNP	A	A	C			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr16:23098411A>C	ENST00000219689.7	-	9	1622		c.e9+1			NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31						ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		aattttttttaCCTTTCTACT	0.388000													21	6					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222716982	222716982	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr1:222716982T>C	ENST00000343410.6	-	2	929	c.871A>G	c.(871-873)Att>Gtt	p.I291V		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	291					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		GAATAATAAATATAGAACTTG	0.463000													99	98					0	0	1	0	0
SMC4	10051	broad.mit.edu	37	3	160138554	160138554	+	Silent	SNP	A	A	G			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:160138554A>G	ENST00000357388.3	+	13	2335	c.1884A>G	c.(1882-1884)aaA>aaG	p.K628K	RP11-432B6.3_ENST00000483754.1_Intron|SMC4_ENST00000462787.1_Silent_p.K628K|SMC4_ENST00000469762.1_Silent_p.K603K|SMC4_ENST00000344722.5_Silent_p.K628K|SMC4_ENST00000360111.2_Silent_p.K628K	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	628	Flexible hinge.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TTGATGAAAAATACGACGTGG	0.373000													13	77					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25953365	25953365	+	Silent	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr15:25953365G>A	ENST00000356865.6	-	11	2538	c.2427C>T	c.(2425-2427)cgC>cgT	p.R809R		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	809					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TGCACAAGGTGCGCAGGCCTT	0.582000													13	48					0	0	1	0	0
C8orf76	84933	broad.mit.edu	37	8	124250060	124250060	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr8:124250060G>A	ENST00000276704.4	-	3	386	c.335C>T	c.(334-336)gCg>gTg	p.A112V	C8orf76_ENST00000521310.1_5'UTR|ZHX1-C8ORF76_ENST00000357082.4_Missense_Mutation_p.A80V	NM_032847.2	NP_116236.1	Q96K31	CH076_HUMAN	chromosome 8 open reading frame 76	112							binding			NS(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(4)	17	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			AATCTCCAGCGCCTCCATATG	0.423000													10	36					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34242499	34242499	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr20:34242499G>A	ENST00000374114.3	-	3	1009	c.746C>T	c.(745-747)cCg>cTg	p.P249L	RBM12_ENST00000374104.3_Missense_Mutation_p.P249L|CPNE1_ENST00000397445.1_Intron|RP1-309K20.6_ENST00000541176.2_Intron|RBM12_ENST00000359646.1_Missense_Mutation_p.P249L|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000352393.4_Intron|CPNE1_ENST00000397443.1_Intron|CPNE1_ENST00000397442.1_Intron|CPNE1_ENST00000397446.1_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	249	Pro-rich.					nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			CACAGGTGGCGGATTCAAGGG	0.547000													11	115					0	0	1	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136305585	136305585	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr9:136305585G>A	ENST00000371929.3	+	16	2351	c.1907G>A	c.(1906-1908)cGg>cAg	p.R636Q	ADAMTS13_ENST00000536611.1_Missense_Mutation_p.R308Q|ADAMTS13_ENST00000371916.1_3'UTR|ADAMTS13_ENST00000356589.2_Missense_Mutation_p.R605Q|ADAMTS13_ENST00000355699.2_Missense_Mutation_p.R636Q|ADAMTS13_ENST00000485925.1_3'UTR	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	636	Spacer.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		ACCGAGGACCGGCTGCCCCGC	0.637000													7	0					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70370981	70370981	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr13:70370981C>G	ENST00000377844.4	-	7	2287	c.1528G>C	c.(1528-1530)Gta>Cta	p.V510L	KLHL1_ENST00000545028.1_Missense_Mutation_p.V317L	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	510					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CCTCCAATTACAAAGAGTTTG	0.423000													53	64					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767603	77767603	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr8:77767603G>A	ENST00000521891.2	+	10	8894	c.8446G>A	c.(8446-8448)Gga>Aga	p.G2816R	ZFHX4_ENST00000455469.2_Missense_Mutation_p.G2771R|ZFHX4_ENST00000050961.6_Missense_Mutation_p.G2771R|ZFHX4_ENST00000518282.1_Missense_Mutation_p.G2790R	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2771						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CGCCACCACCGGAGACGAGGG	0.473000										HNSCC(33;0.089)			35	27					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228400285	228400285	+	Silent	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr1:228400285C>T	ENST00000570156.2	+	2	875	c.801C>T	c.(799-801)ccC>ccT	p.P267P	OBSCN_ENST00000366707.4_5'UTR|C1orf145_ENST00000295012.5_Intron|OBSCN_ENST00000422127.1_Silent_p.P267P|OBSCN_ENST00000284548.11_Silent_p.P267P|OBSCN_ENST00000366709.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	267	Ig-like 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGCCCAAGCCCGAGACGGTGT	0.687000													7	54					0	0	1	0	0
KBTBD12	166348	broad.mit.edu	37	3	127642758	127642758	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:127642758C>A	ENST00000405109.1	+	2	1321	c.854C>A	c.(853-855)tCa>tAa	p.S285*	KBTBD12_ENST00000343941.4_Intron|KBTBD12_ENST00000405256.1_Nonsense_Mutation_p.S285*|KBTBD12_ENST00000407609.3_Intron			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	285										endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						AACAATTCTTCAGGAATCAGA	0.438000													30	38					3.99451e-17	4.42869e-17	1	1	0
CYP2A13	1553	broad.mit.edu	37	19	41600941	41600941	+	Silent	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr19:41600941C>T	ENST00000330436.3	+	8	1239	c.1239C>T	c.(1237-1239)ccC>ccT	p.P413P		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	413					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	ACTTCAATCCCCAGCACTTCC	0.562000													36	61					0	0	1	0	0
HEPACAM	220296	broad.mit.edu	37	11	124792321	124792321	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr11:124792321C>T	ENST00000298251.4	-	6	1316	c.911G>A	c.(910-912)cGg>cAg	p.R304Q		NM_152722.4	NP_689935.2	Q14CZ8	HECAM_HUMAN	hepatic and glial cell adhesion molecule	304					cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		GGGGTTCTTCCGTTCCTGCTC	0.607000													37	87					0	0	1	0	0
SOX8	30812	broad.mit.edu	37	16	1034725	1034725	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr16:1034725C>T	ENST00000293894.3	+	3	795	c.680C>T	c.(679-681)cCg>cTg	p.P227L		NM_014587.3	NP_055402.2	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	227					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|lung(5)|prostate(2)|skin(1)	10		Hepatocellular(780;0.00308)				CCGCCCACCCCGCCCACCACC	0.731000													3	6					0	0	1	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098888	178098888	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr2:178098888T>G	ENST00000397062.3	-	2	711	c.157A>C	c.(157-159)Aaa>Caa	p.K53Q	NFE2L2_ENST00000464747.1_Missense_Mutation_p.K37Q|NFE2L2_ENST00000446151.2_Missense_Mutation_p.K37Q|NFE2L2_ENST00000397063.4_Missense_Mutation_p.K37Q|NFE2L2_ENST00000423513.1_Missense_Mutation_p.K37Q	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	53					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TTTTCAAGTTTTTTCTGTTTT	0.393000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			56	48					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1806089	1806089	+	Missense_Mutation	SNP	G	G	T	rs121913479		TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr4:1806089G>T	ENST00000340107.4	+	9	1370	c.1114G>T	c.(1114-1116)Ggc>Tgc	p.G372C	FGFR3_ENST00000481110.2_Missense_Mutation_p.G370C|FGFR3_ENST00000352904.1_Intron|FGFR3_ENST00000260795.2_Missense_Mutation_p.G370C|FGFR3_ENST00000440486.2_Missense_Mutation_p.G370C|FGFR3_ENST00000412135.2_Intron	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	370					bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.G370C(108)|p.A369_G370>VC(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	TGACGAGGCGGGCAGTGTGTA	0.687000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				89	78					7.49063e-41	8.58477e-41	1	1	0
XKR4	114786	broad.mit.edu	37	8	56435849	56435849	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr8:56435849C>T	ENST00000327381.6	+	3	1116	c.1016C>T	c.(1015-1017)gCg>gTg	p.A339V		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4							integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			GGTTTCACAGCGGCAGCTTCC	0.587000													6	27					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124382176	124382176	+	Silent	SNP	A	A	G	rs148244463		TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr8:124382176A>G	ENST00000287394.5	-	7	923	c.816T>C	c.(814-816)gaT>gaC	p.D272D	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	272	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			catcatcatcatcatcatcgt	0.363000													8	51					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113742940	113742940	+	Silent	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr13:113742940C>T	ENST00000397030.1	+	25	2968	c.2931C>T	c.(2929-2931)acC>acT	p.T977T	MCF2L_ENST00000375608.3_Silent_p.T974T|MCF2L_ENST00000375597.4_Silent_p.T942T|MCF2L_ENST00000375601.3_Silent_p.T948T|MCF2L_ENST00000535094.2_Silent_p.T944T|MCF2L_ENST00000434480.2_Silent_p.T950T|MCF2L_ENST00000423482.2_Silent_p.T942T|MCF2L_ENST00000375604.2_Silent_p.T1001T|MCF2L_ENST00000442652.2_Silent_p.T974T|MCF2L_ENST00000421756.1_Silent_p.T948T			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	974					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CGACCAGCACCAGGTGAGAAT	0.672000													3	3					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67331479	67331479	+	Silent	SNP	G	G	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr16:67331479G>T	ENST00000304372.5	-	7	1129	c.1074C>A	c.(1072-1074)atC>atA	p.I358I		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	358						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GCTCGTAGGTGATGTCCCTTT	0.512000													13	34					2.27111e-07	2.41305e-07	1	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146829392	146829392	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr7:146829392C>T	ENST00000361727.3	+	8	1655	c.1139C>T	c.(1138-1140)gCt>gTt	p.A380V		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	380					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTTTTCAACGCTACAAGTTAC	0.458000										HNSCC(39;0.1)			19	76					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56586092	56586092	+	Silent	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr18:56586092G>A	ENST00000336078.4	+	4	1349	c.573G>A	c.(571-573)acG>acA	p.T191T	ZNF532_ENST00000589288.1_Silent_p.T191T|ZNF532_ENST00000591083.1_Silent_p.T191T|ZNF532_ENST00000591230.1_Silent_p.T191T|ZNF532_ENST00000591808.1_Silent_p.T191T	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						GACTCTCTACGTCAGGCAATG	0.473000													59	41					0	0	1	0	0
ZNF549	256051	broad.mit.edu	37	19	58050032	58050032	+	Missense_Mutation	SNP	G	G	A	rs140955096		TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr19:58050032G>A	ENST00000376233.3	+	4	1841	c.1660G>A	c.(1660-1662)Gaa>Aaa	p.E554K	ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000601415.1_Intron|ZNF549_ENST00000240719.3_Missense_Mutation_p.E541K	NM_001199295.1	NP_001186224	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E541*(1)|p.E554*(1)		NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCACACTGGCGAAAAGCCCTG	0.448000													34	50					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400795	195400795	+	RNA	SNP	C	C	T	rs7615357	by1000genomes	TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:195400795C>T	ENST00000445430.1	+	0	1391																											GGGGCAAACTCGCTGTTGGAC	0.592000													3	19					0	0	1	0	0
GP9	2815	broad.mit.edu	37	3	128780644	128780644	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:128780644C>T	ENST00000307395.4	+	3	284	c.62C>T	c.(61-63)cCc>cTc	p.P21L		NM_000174.3	NP_000165.1	P14770	GPIX_HUMAN	glycoprotein IX (platelet)	21	LRRNT.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding			NS(1)|central_nervous_system(1)|lung(4)	6					Quinine(DB00468)	AAGGACTGCCCCAGCCCATGT	0.711000													11	5					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75969200	75969200	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr15:75969200C>T	ENST00000308508.5	-	10	5752	c.5660G>A	c.(5659-5661)gGc>gAc	p.G1887D	CTD-2026K11.1_ENST00000569467.1_RNA	NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1887	Cysteine-containing.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GGGCCCCAGGCCACCACCCAC	0.667000													7	2					0	0	1	0	0
IL10RA	3587	broad.mit.edu	37	11	117866399	117866399	+	Missense_Mutation	SNP	C	C	T	rs149491038		TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr11:117866399C>T	ENST00000227752.3	+	6	904	c.784C>T	c.(784-786)Cgc>Tgc	p.R262C	IL10RA_ENST00000545409.1_Missense_Mutation_p.R113C|IL10RA_ENST00000533700.1_3'UTR|IL10RA_ENST00000541785.1_Missense_Mutation_p.R242C	NM_001558.3	NP_001549.2	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha	262						integral to membrane|plasma membrane	interleukin-10 receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		GTATGTGCGGCGCCGAAAGAA	0.602000													9	18					0	0	1	0	0
SFXN2	118980	broad.mit.edu	37	10	104489106	104489106	+	Silent	SNP	A	A	G			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr10:104489106A>G	ENST00000369893.5	+	5	629	c.462A>G	c.(460-462)acA>acG	p.T154T		NM_178858.4	NP_849189.1	Q96NB2	SFXN2_HUMAN	sideroflexin 2					QMALSYFTATTTAVATAVGMNMLTKKAPPLVGRWVPFAAVA AANCVNIPMMRQQELIKGI -> KRRPWWAAGCPLPLWLRL TVSISP (in Ref. 2).	iron ion homeostasis	integral to membrane	cation transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|prostate(1)	13		Colorectal(252;0.207)		Epithelial(162;4.53e-09)|all cancers(201;1.2e-07)|BRCA - Breast invasive adenocarcinoma(275;0.218)		TCACAGCCACAACCACTGCTG	0.637000											OREG0020485	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	10					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25953366	25953366	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr15:25953366C>A	ENST00000356865.6	-	11	2537	c.2426G>T	c.(2425-2427)cGc>cTc	p.R809L		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	809					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCACAAGGTGCGCAGGCCTTC	0.582000													13	48					0.000219431	0.000228388	1	1	0
FLG	2312	broad.mit.edu	37	1	152275948	152275948	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr1:152275948C>T	ENST00000368799.1	-	3	11449	c.11414G>A	c.(11413-11415)gGa>gAa	p.G3805E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3805	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTTCTGGATCCTGACTGCCC	0.567000									Ichthyosis				69	303					0	0	1	0	0
PTGR1	22949	broad.mit.edu	37	9	114337106	114337106	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr9:114337106G>A	ENST00000407693.2	-	8	930	c.668C>T	c.(667-669)tCa>tTa	p.S223L	RP11-16L21.7_ENST00000450154.1_RNA|PTGR1_ENST00000538962.1_Missense_Mutation_p.S223L|PTGR1_ENST00000238248.3_Missense_Mutation_p.S100L|ZNF483_ENST00000358151.4_Intron|PTGR1_ENST00000309195.5_Missense_Mutation_p.S223L	NM_001146108.1	NP_001139580.1	Q14914	PTGR1_HUMAN	prostaglandin reductase 1	223					leukotriene metabolic process	cytoplasm	15-oxoprostaglandin 13-oxidase activity|2-alkenal reductase activity|alcohol dehydrogenase (NAD) activity|zinc ion binding			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)	11						AACAGTGTTTGAAAACTCTCC	0.383000													27	2					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71026115	71026115	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:71026115G>A	ENST00000318789.4	-	17	2032	c.1507C>T	c.(1507-1509)Cga>Tga	p.R503*	FOXP1_ENST00000491238.1_Nonsense_Mutation_p.R505*|FOXP1_ENST00000475937.1_Nonsense_Mutation_p.R503*|FOXP1_ENST00000468577.1_Nonsense_Mutation_p.R503*|FOXP1_ENST00000498215.1_Nonsense_Mutation_p.R503*|FOXP1_ENST00000484350.1_Nonsense_Mutation_p.R427*|FOXP1_ENST00000493089.1_Nonsense_Mutation_p.R502*	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	503					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GCGTTGCGTCGGAAGTAAGCA	0.428000			T	PAX5	ALL								22	36					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178951955	178951955	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:178951955A>G	ENST00000263967.3	+	21	3167	c.3010A>G	c.(3010-3012)Atg>Gtg	p.M1004V		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1004	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCTTTTCTCAATGATGCTTGG	0.388000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			25	39					0	0	1	0	0
OR8B3	390271	broad.mit.edu	37	11	124266950	124266950	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr11:124266950G>C	ENST00000354597.3	-	1	314	c.298C>G	c.(298-300)Cag>Gag	p.Q100E		NM_001005467.1	NP_001005467.1	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B, member 3	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AAAAACAGCTGAGTCATGCAC	0.368000													5	43					0	0	1	0	0
RHOB	388	broad.mit.edu	37	2	20647419	20647419	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr2:20647419G>T	ENST00000272233.4	+	1	585	c.193G>T	c.(193-195)Gac>Tac	p.D65Y		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	65					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GGGCCAGGAGGACTACGACCG	0.642000													46	43					5.2432e-18	5.877e-18	1	1	0
TNRC18	84629	broad.mit.edu	37	7	5347790	5347790	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr7:5347790C>T	ENST00000399537.4	-	30	9202	c.8854G>A	c.(8854-8856)Gag>Aag	p.E2952K	TNRC18_ENST00000430969.1_Missense_Mutation_p.E2952K			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2952	BAH.						DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GTGGTGGGCTCGTAGGTGCCC	0.677000													4	6					0	0	1	0	0
NACC1	112939	broad.mit.edu	37	19	13246329	13246329	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr19:13246329C>T	ENST00000292431.4	+	2	434	c.308C>T	c.(307-309)aCg>aTg	p.T103M		NM_052876.3	NP_443108.1	Q96RE7	NACC1_HUMAN	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	103					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body				endometrium(3)|large_intestine(2)|lung(3)|skin(1)	9						CTCATGTACACGGCTGGCTTC	0.627000													11	24					0	0	1	0	0
GOLGA6L17P	642402	broad.mit.edu	37	15	85053124	85053124	+	RNA	SNP	G	G	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr15:85053124G>T	ENST00000414190.2	-	0	328					NR_003246.2																						TAAATGTTTTGTTTTTTTTTT	0.353000													3	18					0.115264	0.117569	1	1	0
AHNAK2	113146	broad.mit.edu	37	14	105420733	105420733	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr14:105420733C>T	ENST00000333244.5	-	7	1174	c.1055G>A	c.(1054-1056)cGt>cAt	p.R352H		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	352						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GACCCCAGCACGGCCCACCCC	0.642000													13	23					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16967689	16967689	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr10:16967689G>A	ENST00000377833.4	-	42	6421	c.6356C>T	c.(6355-6357)tCt>tTt	p.S2119F		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2119	CUB 15.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GACGTGCCAAGAACAGTTGAG	0.498000													34	19					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371373	240371373	+	Silent	SNP	A	A	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr1:240371373A>T	ENST00000319653.9	+	5	3491	c.3261A>T	c.(3259-3261)ccA>ccT	p.P1087P		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1087	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCATACCCCCACCTCCCCCTC	0.726000													3	10					0	0	1	0	0
NAALADL2	254827	broad.mit.edu	37	3	175189438	175189438	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:175189438G>T	ENST00000454872.1	+	9	1673	c.1545G>T	c.(1543-1545)aaG>aaT	p.K515N	NAALADL2_ENST00000473253.1_3'UTR	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	515					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		ATTTCAAGAAGGTTCTTCAGA	0.343000													3	10					0.004672	0.00481358	1	1	0
SYNJ2	8871	broad.mit.edu	37	6	158492757	158492757	+	Silent	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr6:158492757C>T	ENST00000355585.4	+	15	2139	c.2064C>T	c.(2062-2064)gcC>gcT	p.A688A	SYNJ2_ENST00000367122.2_Silent_p.A688A|SYNJ2_ENST00000367121.3_Silent_p.A688A	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	688							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		ACCTGACGGCCGGGCAGTCCC	0.617000													13	19					0	0	1	0	0
KLHL3	26249	broad.mit.edu	37	5	136973012	136973012	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr5:136973012C>T	ENST00000508657.1	-	11	1910	c.1196G>A	c.(1195-1197)cGg>cAg	p.R399Q	KLHL3_ENST00000309755.4_Missense_Mutation_p.R431Q|KLHL3_ENST00000506873.1_Intron|KLHL3_ENST00000541417.1_Intron|KLHL3_ENST00000506491.1_Missense_Mutation_p.R349Q	NM_001257194.1	NP_001244123.1	Q9UH77	KLHL3_HUMAN	kelch-like family member 3	431						cytoplasm|cytoskeleton	actin binding|structural molecule activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		CACACTGCTCCGCCGCGTGTT	0.617000													8	30					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11144846	11144846	+	Silent	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr19:11144846C>T	ENST00000358026.2	+	28	4205	c.3921C>T	c.(3919-3921)gcC>gcT	p.A1307A	SMARCA4_ENST00000450717.3_Silent_p.A1274A|SMARCA4_ENST00000429416.3_Silent_p.A1307A|SMARCA4_ENST00000444061.3_Silent_p.A1274A|SMARCA4_ENST00000413806.3_Silent_p.A1274A|SMARCA4_ENST00000589677.1_Silent_p.A1274A|SMARCA4_ENST00000538456.3_3'UTR|SMARCA4_ENST00000590574.1_Silent_p.A1274A|SMARCA4_ENST00000344626.4_Silent_p.A1307A|SMARCA4_ENST00000541122.2_Silent_p.A1274A	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1307					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AGATGATCGCCCGGCACGAGG	0.612000			"""F, N, Mis"""		NSCLC								21	36					0	0	1	0	0
FUK	197258	broad.mit.edu	37	16	70509255	70509255	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr16:70509255G>A	ENST00000288078.6	+	19	2612	c.2380G>A	c.(2380-2382)Gcc>Acc	p.A794T	FUK_ENST00000378912.2_Missense_Mutation_p.A826T|FUK_ENST00000571514.1_Missense_Mutation_p.A285T	NM_145059.2	NP_659496.2	Q8N0W3	FUK_HUMAN	fucokinase	794						cytoplasm	ATP binding|fucokinase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(11)|ovary(2)|prostate(2)	23		Ovarian(137;0.0694)				TTCTGCAGGGGCCCTGCTGAA	0.627000													25	18					0	0	1	0	0
IDE	3416	broad.mit.edu	37	10	94215367	94215367	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr10:94215367T>C	ENST00000265986.6	-	24	2986	c.2930A>G	c.(2929-2931)gAc>gGc	p.D977G	IDE_ENST00000371581.5_Missense_Mutation_p.D422G|IDE_ENST00000496903.1_5'UTR	NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	977					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAAATTTATGTCATTTTGACA	0.323000													8	29					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40076785	40076785	+	Silent	SNP	A	A	G			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr12:40076785A>G	ENST00000324616.5	+	8	1213	c.1059A>G	c.(1057-1059)ccA>ccG	p.P353P	C12orf40_ENST00000405531.3_Silent_p.P353P|C12orf40_ENST00000398716.1_Silent_p.P276P	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	353										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						TTACAGTTCCAGAGTTGACTT	0.323000													14	11					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													5	103					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28844818	28844818	+	Silent	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr16:28844818C>T	ENST00000336783.4	+	15	2181	c.2014C>T	c.(2014-2016)Ctg>Ttg	p.L672L	ATXN2L_ENST00000395547.2_Silent_p.L672L|ATXN2L_ENST00000564304.1_Silent_p.L678L|ATXN2L_ENST00000570200.1_Silent_p.L672L|ATXN2L_ENST00000565845.1_3'UTR|ATXN2L_ENST00000340394.8_Silent_p.L672L|ATXN2L_ENST00000382686.4_Silent_p.L672L|ATXN2L_ENST00000325215.6_Silent_p.L672L|RP11-24N18.1_ENST00000563565.1_RNA	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	672						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						TACAAAGCCTCTGCTGTCTGT	0.458000													16	33					0	0	1	0	0
PYGO2	90780	broad.mit.edu	37	1	154931569	154931569	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr1:154931569G>C	ENST00000368457.2	-	3	1078	c.907C>G	c.(907-909)Cca>Gca	p.P303A	PYGO2_ENST00000368456.1_Missense_Mutation_p.P266A	NM_138300.3	NP_612157.1	Q9BRQ0	PYGO2_HUMAN	pygopus family PHD finger 2	303	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			endometrium(2)|large_intestine(2)|lung(3)|skin(2)|urinary_tract(1)	10	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTGGCATCTGGAGTGCCCCCA	0.672000													6	6					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884816	24884816	+	Silent	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr14:24884816C>T	ENST00000382554.3	+	9	4179	c.3861C>T	c.(3859-3861)ccC>ccT	p.P1287P		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1287					DNA integration	integral to membrane	DNA binding	p.P1287P(1)		breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TGCTCACCCCCGCGGCCTCCA	0.622000													5	110					0	0	1	0	0
RNF39	80352	broad.mit.edu	37	6	30043392	30043392	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr6:30043392C>A	ENST00000244360.6	-	1	272	c.175G>T	c.(175-177)Gaa>Taa	p.E59*	RNF39_ENST00000376751.3_Nonsense_Mutation_p.E59*	NM_025236.3	NP_079512.2	Q9H2S5	RNF39_HUMAN	ring finger protein 39	59						cytoplasm	zinc ion binding										GCCGCCCCTTCCGCGACCACC	0.677000													17	14					2.35188e-11	2.55204e-11	1	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144917523	144917523	+	Silent	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr1:144917523G>A	ENST00000529945.1	-	8	2509	c.2070C>T	c.(2068-2070)ctC>ctT	p.L690L	PDE4DIP_ENST00000369359.4_Silent_p.L664L|PDE4DIP_ENST00000530740.1_Silent_p.L664L|PDE4DIP_ENST00000369354.3_Silent_p.L527L|PDE4DIP_ENST00000369356.4_Silent_p.L527L|PDE4DIP_ENST00000369351.3_Silent_p.L527L|PDE4DIP_ENST00000313382.9_Silent_p.L593L|PDE4DIP_ENST00000479408.2_Silent_p.L314L|PDE4DIP_ENST00000313431.9_Silent_p.L690L|PDE4DIP_ENST00000369349.3_Silent_p.L527L			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	527					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CATTGGAGGAGAGGACATCGC	0.473000			T	PDGFRB	MPD								80	286					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11008369	11008369	+	Missense_Mutation	SNP	C	C	T	rs147303952		TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr1:11008369C>T	ENST00000377004.4	-	12	1822	c.1823G>A	c.(1822-1824)cGt>cAt	p.R608H	C1orf127_ENST00000377008.4_Missense_Mutation_p.R441H	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	459										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		TCCGGGAGAACGGTGAGAAAC	0.682000													29	36					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28844383	28844383	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr16:28844383C>A	ENST00000336783.4	+	14	1830	c.1663C>A	c.(1663-1665)Cag>Aag	p.Q555K	ATXN2L_ENST00000395547.2_Missense_Mutation_p.Q555K|ATXN2L_ENST00000564304.1_Missense_Mutation_p.Q561K|ATXN2L_ENST00000570200.1_Missense_Mutation_p.Q555K|ATXN2L_ENST00000340394.8_Missense_Mutation_p.Q555K|ATXN2L_ENST00000382686.4_Missense_Mutation_p.Q555K|ATXN2L_ENST00000325215.6_Missense_Mutation_p.Q555K|RP11-24N18.1_ENST00000563565.1_RNA	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	555						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						CTTCCAGCTTCAGCCCAGTAG	0.493000													39	82					1.8453e-21	2.09134e-21	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414379	20414379	+	Silent	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr9:20414379G>A	ENST00000380338.4	-	5	751	c.465C>T	c.(463-465)agC>agT	p.S155S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S152S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	155	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S155S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.532000			T	MLL	ALL								4	29					0	0	1	0	0
LYZ	4069	broad.mit.edu	37	12	69746059	69746059	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr12:69746059C>T	ENST00000261267.2	+	3	429	c.361C>T	c.(361-363)Cca>Tca	p.P121S	LYZ_ENST00000549690.1_Intron	NM_000239.2	NP_000230.1	P61626	LYSC_HUMAN	lysozyme	121					cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding			endometrium(2)|lung(1)|upper_aerodigestive_tract(1)	4	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			TGTCCGTGATCCACAAGGCAT	0.368000													18	401					0	0	1	0	0
PUSL1	126789	broad.mit.edu	37	1	1246021	1246021	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr1:1246021C>T	ENST00000379031.5	+	6	729	c.652C>T	c.(652-654)Cgg>Tgg	p.R218W	PUSL1_ENST00000470520.1_3'UTR	NM_153339.1	NP_699170.1	Q8N0Z8	PUSL1_HUMAN	pseudouridylate synthase-like 1	218					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			lung(3)|skin(1)|urinary_tract(1)	5	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CAGGAAGCTGCGGTTCTGGAA	0.592000													4	166					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74639685	74639685	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr17:74639685G>C	ENST00000156626.7	-	1	235	c.36C>G	c.(34-36)agC>agG	p.S12R	ST6GALNAC1_ENST00000589992.1_Missense_Mutation_p.S12R|ST6GALNAC1_ENST00000590878.1_5'UTR	NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	12					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						GGACGCCTTGGCTCAGGTGCC	0.557000													13	21					0	0	1	0	0
LYZ	4069	broad.mit.edu	37	12	69746969	69746969	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr12:69746969C>T	ENST00000549690.1	+	3	363	c.338C>T	c.(337-339)tCc>tTc	p.S113F	LYZ_ENST00000261267.2_Silent_p.V139V			P61626	LYSC_HUMAN	lysozyme	0					cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding			endometrium(2)|lung(1)|upper_aerodigestive_tract(1)	4	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			ACAGAGATGTCCGTCAGTATG	0.373000													31	630					0	0	1	0	0
CNOT10	25904	broad.mit.edu	37	3	32745388	32745388	+	Silent	SNP	A	A	G			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:32745388A>G	ENST00000328834.5	+	2	367	c.51A>G	c.(49-51)acA>acG	p.T17T	CNOT10_ENST00000538368.1_5'UTR|CNOT10_ENST00000331889.6_Silent_p.T17T|CNOT10_ENST00000454516.2_Silent_p.T77T	NM_015442.2	NP_056257.1	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	17					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(3)	23						ATGAAGGCACAGGTCAGTCCT	0.423000													7	22					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40398380	40398380	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr19:40398380C>T	ENST00000221347.6	-	14	6594	c.6587G>A	c.(6586-6588)cGc>cAc	p.R2196H		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	2196	VWFD 5.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CACGCGCAGGCGCACGAAGCT	0.687000													17	141					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20944671	20944671	+	Silent	SNP	T	T	C			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr16:20944671T>C	ENST00000261383.3	-	62	12155	c.12156A>G	c.(12154-12156)aaA>aaG	p.K4052K	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	4052					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCTCCCCAGGTTTCAGCCAAA	0.522000													66	39					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13415345	13415345	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:13415345C>T	ENST00000254508.5	-	12	1542	c.1460G>A	c.(1459-1461)tGg>tAg	p.W487*		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	487	Poly-Ser.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TGACGAAGACCAGCTGAAGTT	0.587000													10	15					0	0	1	0	0
FAM71C	196472	broad.mit.edu	37	12	100042312	100042312	+	Silent	SNP	G	G	C			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr12:100042312G>C	ENST00000324341.1	+	1	782	c.360G>C	c.(358-360)ctG>ctC	p.L120L	ANKS1B_ENST00000547010.1_Intron|ANKS1B_ENST00000329257.7_Intron|ANKS1B_ENST00000547776.2_Intron	NM_153364.3	NP_699195.1	Q8NEG0	FA71C_HUMAN	family with sequence similarity 71, member C	120										breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(2;0.00733)|Epithelial(2;0.0385)|all cancers(2;0.19)		TAACCAGGCTGCTTCCCTTGA	0.512000													20	52					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	73108737	73108737	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr6:73108737G>A	ENST00000264839.7	+	29	4348	c.4348G>A	c.(4348-4350)Gat>Aat	p.D1450N	RIMS1_ENST00000538414.1_Missense_Mutation_p.D407N|RIMS1_ENST00000520567.1_Missense_Mutation_p.D1251N|RIMS1_ENST00000431478.2_3'UTR|RIMS1_ENST00000491071.2_Missense_Mutation_p.D1390N|RIMS1_ENST00000348717.5_Missense_Mutation_p.D1384N|RIMS1_ENST00000517960.1_Missense_Mutation_p.D1384N|RIMS1_ENST00000518273.1_Missense_Mutation_p.D1280N|RIMS1_ENST00000414192.2_Missense_Mutation_p.D128N|RIMS1_ENST00000517827.1_Missense_Mutation_p.D735N|RIMS1_ENST00000401910.3_Missense_Mutation_p.D921N|RIMS1_ENST00000425662.2_Missense_Mutation_p.D669N|RIMS1_ENST00000522291.1_Missense_Mutation_p.D1200N|RIMS1_ENST00000521978.1_Missense_Mutation_p.D1601N|RIMS1_ENST00000523963.1_Missense_Mutation_p.D726N			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1601					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				AAAAACCCTTGATCCTTTGTA	0.368000													27	22					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96798943	96798943	+	Silent	SNP	G	G	C			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr14:96798943G>C	ENST00000359933.4	-	9	2150	c.1257C>G	c.(1255-1257)ctC>ctG	p.L419L		NM_018036.5	NP_060506	Q96BY7	ATG2B_HUMAN	autophagy related 2B	419										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GAAGAGAAGAGAGACTATGAG	0.403000													28	34					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74329260	74329260	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr2:74329260A>G	ENST00000409262.3	+	9	4940	c.4940A>G	c.(4939-4941)tAt>tGt	p.Y1647C		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1647							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GTGTCCTCCTATGCCTACACG	0.652000													4	6					0	0	1	0	0
ACTR3B	57180	broad.mit.edu	37	7	152497630	152497630	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr7:152497630G>T	ENST00000256001.8	+	3	249	c.115G>T	c.(115-117)Gag>Tag	p.E39*	ACTR3B_ENST00000377776.3_Nonsense_Mutation_p.E39*|ACTR3B_ENST00000397282.2_5'UTR|ACTR3B_ENST00000537264.1_Intron	NM_020445.5	NP_065178.1	Q9P1U1	ARP3B_HUMAN	ARP3 actin-related protein 3 homolog B (yeast)	39					regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding			breast(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	13		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)		TGCCATCAGAGAGTCAGCAAA	0.368000													3	61					1	1	1	1	0
ZAN	7455	broad.mit.edu	37	7	100361665	100361665	+	RNA	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr7:100361665C>T	ENST00000542585.1	+	0	4261				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCCTGCTGCACGTGAAGGCCG	0.602000													37	51					0	0	1	0	0
HTR1F	3355	broad.mit.edu	37	3	88040764	88040764	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:88040764C>T	ENST00000319595.4	+	1	919	c.865C>T	c.(865-867)Cgg>Tgg	p.R289W		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	289					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity	p.R289R(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	TACAAGAGAACGGAAAGCAGC	0.378000													5	24					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155264471	155264471	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr1:155264471C>T	ENST00000392414.3	-	6	787	c.674G>A	c.(673-675)gGg>gAg	p.G225E	PKLR_ENST00000342741.4_Missense_Mutation_p.G256E	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	256					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	CACCTGGGCCCCTGGCAAGTT	0.672000													14	25					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64640053	64640053	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:64640053G>A	ENST00000498707.1	-	8	1634	c.1292C>T	c.(1291-1293)aCg>aTg	p.T431M	ADAMTS9_ENST00000459780.1_Missense_Mutation_p.T431M|ADAMTS9_ENST00000295903.4_Missense_Mutation_p.T403M	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	431	Peptidase M12B.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ATGGGCGATCGTAAAAGCTGT	0.403000													71	90					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33518340	33518340	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr2:33518340C>T	ENST00000404816.2	+	20	3579	c.3226C>T	c.(3226-3228)Cac>Tac	p.H1076Y	LTBP1_ENST00000418533.2_Missense_Mutation_p.H750Y|LTBP1_ENST00000404525.1_Missense_Mutation_p.H697Y|LTBP1_ENST00000402934.1_Missense_Mutation_p.H697Y|LTBP1_ENST00000354476.3_Missense_Mutation_p.H1077Y|LTBP1_ENST00000390003.4_Missense_Mutation_p.H751Y|LTBP1_ENST00000498013.1_3'UTR|LTBP1_ENST00000272273.5_Missense_Mutation_p.H16Y|LTBP1_ENST00000407925.1_Missense_Mutation_p.H750Y			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1076	EGF-like 8; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GGACCACAAGCACTGTAGAGG	0.423000													22	35					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	30724739	30724739	+	Silent	SNP	T	T	C			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr4:30724739T>C	ENST00000361762.2	+	1	2703	c.1695T>C	c.(1693-1695)ggT>ggC	p.G565G	PCDH7_ENST00000543491.1_Silent_p.G565G	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	565	Cadherin 5.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						CAGACAGCGGTAAGAACGCCG	0.607000													20	26					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55494473	55494473	+	Silent	SNP	T	T	C	rs1654491		TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr19:55494473T>C	ENST00000543010.1	+	6	1550	c.1407T>C	c.(1405-1407)gaT>gaC	p.D469D	NLRP2_ENST00000263437.6_Silent_p.D466D|NLRP2_ENST00000427260.2_Silent_p.D446D|NLRP2_ENST00000538819.1_Silent_p.D445D|NLRP2_ENST00000339757.7_Silent_p.D447D|NLRP2_ENST00000537859.1_Silent_p.D447D|NLRP2_ENST00000391721.4_Silent_p.D445D|NLRP2_ENST00000448584.2_Silent_p.D469D	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	469	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		ACCGAGAGGATCTGGAAAGGC	0.677000													19	36					0	0	1	0	0
AKR7A2	8574	broad.mit.edu	37	1	19630776	19630776	+	Silent	SNP	A	A	G			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr1:19630776A>G	ENST00000235835.3	-	7	1044	c.1023T>C	c.(1021-1023)gaT>gaC	p.D341D		NM_003689.3	NP_003680.2	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	341					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GATTAAAGGCATCCACGACAG	0.597000													4	78					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400799	195400799	+	RNA	SNP	G	G	A	rs7635172	by1000genomes	TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr3:195400799G>A	ENST00000445430.1	+	0	1395																											CAAACTCGCTGTTGGACCTGG	0.597000													3	20					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19503196	19503196	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr5:19503196G>A	ENST00000507958.1	-	13	2525	c.1535C>T	c.(1534-1536)aCt>aTt	p.T512I	CDH18_ENST00000511273.1_Missense_Mutation_p.T512I|CDH18_ENST00000502796.1_Missense_Mutation_p.T512I|CDH18_ENST00000506372.1_Missense_Mutation_p.T512I|CDH18_ENST00000382275.1_Missense_Mutation_p.T512I|CDH18_ENST00000274170.4_Missense_Mutation_p.T512I			Q13634	CAD18_HUMAN	cadherin 18, type 2	512	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ATCTTTATCAGTGGCACTGAT	0.338000													27	34					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161470145	161470145	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr6:161470145G>A	ENST00000392142.4	+	3	989	c.841G>A	c.(841-843)Gac>Aac	p.D281N	MAP3K4_ENST00000366919.2_Missense_Mutation_p.D281N|MAP3K4_ENST00000366920.2_Missense_Mutation_p.D281N|MAP3K4_ENST00000348824.7_Missense_Mutation_p.D281N	NM_005922.2	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	281					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TAACGACCAGGACTTCTTTTT	0.428000													29	41					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56495733	56495733	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr12:56495733C>T	ENST00000267101.3	+	28	4363	c.3923C>T	c.(3922-3924)gCc>gTc	p.A1308V	ERBB3_ENST00000415288.2_Missense_Mutation_p.A1249V|ERBB3_ENST00000549832.1_Missense_Mutation_p.A428V|RP11-603J24.9_ENST00000548861.1_Intron|ERBB3_ENST00000450146.2_Missense_Mutation_p.A665V|ERBB3_ENST00000553131.1_Missense_Mutation_p.A549V	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	1308					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GTCCATTATGCCCGCCTAAAA	0.527000													4	140					0	0	1	0	0
KCTD18	130535	broad.mit.edu	37	2	201355082	201355082	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr2:201355082C>T	ENST00000359878.3	-	7	1532	c.1022G>A	c.(1021-1023)gGg>gAg	p.G341E	KCTD18_ENST00000409157.1_Missense_Mutation_p.G341E	NM_152387.2	NP_689600.2	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain containing 18	341						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						CTGAGGATGCCCAGGTGCCCC	0.632000													8	55					0	0	1	0	0
EFNB2	1948	broad.mit.edu	37	13	107145542	107145542	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr13:107145542C>A	ENST00000245323.4	-	5	997	c.848G>T	c.(847-849)gGc>gTc	p.G283V		NM_004093.3	NP_004084.1	P52799	EFNB2_HUMAN	ephrin-B2	283					cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					GGGCTCTGAGCCGTTGTTGTT	0.617000													23	31					2.89027e-11	3.10323e-11	1	1	0
PMS2P3	5387	broad.mit.edu	37	7	75142142	75142142	+	RNA	DEL	A	A	-	rs35519730		TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr7:75142142delA	ENST00000418756.1	-	0	991					NR_028059.1															lung(1)	1						tctcaaaaagaaaaaaaaaaa	0.418													4	9	---	---	---	---					
ABTB2	25841	broad.mit.edu	37	11	34378498	34378499	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr11:34378498_34378499insA	ENST00000435224.2	-	1	1056_1057	c.632_633insT	c.(631-633)ttcfs	p.F211fs	ABTB2_ENST00000298992.2_Frame_Shift_Ins_p.F25fs	NM_145804.2	NP_665803.2	A8K6S9	A8K6S9_HUMAN	ankyrin repeat and BTB (POZ) domain containing 2	25							DNA binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				CCATCCAGCGGAAAAAGCGACC	0.668													3	5	---	---	---	---					
GP2	2813	broad.mit.edu	37	16	20329597	20329598	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr16:20329597_20329598delGT	ENST00000302555.5	-	7	1311_1312	c.1162_1163delAC	c.(1162-1164)accfs	p.T388fs	GP2_ENST00000341642.5_Frame_Shift_Del_p.T241fs|GP2_ENST00000381360.5_Frame_Shift_Del_p.T244fs|GP2_ENST00000381362.4_Frame_Shift_Del_p.T391fs			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	391	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AAACCGGGAGGTGTCCCCTTGT	0.500													15	55	---	---	---	---					
SIGLEC12	89858	broad.mit.edu	37	19	52003600	52003600	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4U-01A-11D-A38G-08	TCGA-ZF-AA4U-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c45cc69-1933-4189-8f7f-66a2dc38862d	093de359-7643-4c9d-a88c-58c398319b9d	g.chr19:52003600delC	ENST00000598614.1	-	1	27	c.28delG	c.(28-30)gaafs	p.E11fs	SIGLEC12_ENST00000291707.3_Intron	NM_033329.1	NP_201586.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	0					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TCCCTCTCTTCATTTGCCCAT	0.622													11	14	---	---	---	---					
