Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
H3F3A	3020	broad.mit.edu	37	1	226253371	226253371	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:226253371C>T	ENST00000366814.3	+	3	264	c.143C>T	c.(142-144)gCg>gTg	p.A48V	H3F3A_ENST00000366813.1_Missense_Mutation_p.A48V|H3F3A_ENST00000366815.3_Missense_Mutation_p.A48V|H3F3A_ENST00000366816.1_Missense_Mutation_p.A48V					H3 histone, family 3A											central_nervous_system(116)|endometrium(2)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	123	Breast(184;0.179)			GBM - Glioblastoma multiforme(131;0.203)		GGTACTGTGGCGCTCCGTGAA	0.403000			Mis		glioma								7	52					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8934113	8934113	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:8934113C>A	ENST00000256707.3	-	12	1284	c.1103G>T	c.(1102-1104)gGa>gTa	p.G368V	KIDINS220_ENST00000473731.1_Missense_Mutation_p.G368V|KIDINS220_ENST00000427284.1_Missense_Mutation_p.G368V|KIDINS220_ENST00000418530.1_Missense_Mutation_p.G326V|KIDINS220_ENST00000319688.5_Missense_Mutation_p.G369V	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	368					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GGGAGTATCTCCTTTCTGTAA	0.353000													13	45					2.61681e-11	3.0485e-11	1	1	0
CCNI2	645121	broad.mit.edu	37	5	132084084	132084084	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:132084084C>T	ENST00000378731.1	+	2	526	c.475C>T	c.(475-477)Cgg>Tgg	p.R159W		NM_001039780.2	NP_001034869.1	Q6ZMN8	CCNI2_HUMAN	cyclin I family, member 2	159					regulation of cyclin-dependent protein kinase activity		protein kinase binding			haematopoietic_and_lymphoid_tissue(1)|prostate(1)|urinary_tract(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTGGCTCCTGCGGCTTCAGAA	0.572000													4	100					0	0	1	0	0
ARFGAP2	84364	broad.mit.edu	37	11	47187881	47187881	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:47187881C>T	ENST00000524782.1	-	15	1711	c.1483G>A	c.(1483-1485)Ggt>Agt	p.G495S	ARFGAP2_ENST00000319543.6_Missense_Mutation_p.G226S|ARFGAP2_ENST00000426335.2_Missense_Mutation_p.G359S|ARFGAP2_ENST00000419701.2_Missense_Mutation_p.G388S|ARFGAP2_ENST00000395449.3_5'UTR	NM_001242832.1|NM_032389.4	NP_001229761.1|NP_115765.2	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating protein 2	495	Required for interaction with coatomer.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						GACTTGACACCCTGCTTAAAC	0.552000													9	100					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224463439	224463439	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:224463439C>T	ENST00000305409.2	-	2	794	c.562G>A	c.(562-564)Gaa>Aaa	p.E188K		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	188					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		GTATATTGTTCCTCCACTATT	0.443000													28	132					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142658955	142658955	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:142658955C>T	ENST00000355265.2	-	2	482	c.8G>A	c.(7-9)gGt>gAt	p.G3D	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	3					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TTGGTCCCCACCTTCCTGAAG	0.552000													23	100					0	0	1	0	0
CLPTM1L	81037	broad.mit.edu	37	5	1331945	1331945	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:1331945C>G	ENST00000320895.5	-	8	1202	c.945G>C	c.(943-945)aaG>aaC	p.K315N	CLPTM1L_ENST00000320927.6_Missense_Mutation_p.K315N|CLPTM1L_ENST00000507807.1_Missense_Mutation_p.K182N	NM_030782.3	NP_110409.2	Q96KA5	CLP1L_HUMAN	CLPTM1-like	315					apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		TCATGCTCTTCTTCTTCTTCC	0.532000													5	36					0	0	1	0	0
IDO1	3620	broad.mit.edu	37	8	39780080	39780080	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:39780080C>A	ENST00000518237.1	+	6	1086	c.447C>A	c.(445-447)gaC>gaA	p.D149E	IDO1_ENST00000522495.1_Missense_Mutation_p.D149E|RP11-44K6.3_ENST00000517623.1_RNA	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	149					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	GGAACATGGACGTTTTGTTCT	0.358000													8	21					0.307466	0.307916	1	1	0
TRPC1	7220	broad.mit.edu	37	3	142509908	142509908	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:142509908G>T	ENST00000273482.6	+	7	1634	c.1243G>T	c.(1243-1245)Gac>Tac	p.D415Y	TRPC1_ENST00000476941.1_Missense_Mutation_p.D449Y	NM_003304.4	NP_003295.1	P48995	TRPC1_HUMAN	transient receptor potential cation channel, subfamily C, member 1	449					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity	p.D415Y(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(2)|stomach(3)|urinary_tract(1)	37						AGGGTTGGAAGACTTTTTAGA	0.343000													3	54					1	1	1	1	0
TNFAIP8L2	79626	broad.mit.edu	37	1	151131418	151131418	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:151131418G>A	ENST00000368910.3	+	2	371	c.245G>A	c.(244-246)aGt>aAt	p.S82N		NM_024575.4	NP_078851.2	Q6P589	TP8L2_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 2	82					innate immune response					lung(1)|skin(2)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTTGGCCCCAGTGAGCTGGCC	0.617000													12	35					0	0	1	0	0
INVS	27130	broad.mit.edu	37	9	103015222	103015222	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:103015222G>A	ENST00000262457.2	+	10	1453	c.1268G>A	c.(1267-1269)gGa>gAa	p.G423E	INVS_ENST00000262456.2_Missense_Mutation_p.G423E|INVS_ENST00000541287.1_Missense_Mutation_p.G327E	NM_014425.3	NP_055240.2	Q9Y283	INVS_HUMAN	inversin	423					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Acute lymphoblastic leukemia(62;0.056)				GACCAAGATGGACATTCTCTT	0.368000													5	37					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7949320	7949320	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:7949320A>G	ENST00000309838.2	-	1	889	c.890T>C	c.(889-891)aTg>aCg	p.M297T		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGCCCTCTTCATCTCACTATT	0.423000													16	82					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128903486	128903486	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:128903486T>C	ENST00000375990.3	+	18	2292	c.1889T>C	c.(1888-1890)aTc>aCc	p.I630T	UGGT1_ENST00000259253.6_Missense_Mutation_p.I654T			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	654					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TTAGAAACCATCACAATGCAT	0.468000													21	74					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32734865	32734865	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:32734865G>C	ENST00000421745.2	+	52	10175	c.10041G>C	c.(10039-10041)atG>atC	p.M3347I		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	3347					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TAGAAGGAATGATGGCAAGTG	0.418000													5	164					0	0	1	0	0
ZNF714	148206	broad.mit.edu	37	19	21300016	21300016	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:21300016G>A	ENST00000596143.1	+	5	871	c.546G>A	c.(544-546)aaG>aaA	p.K182K	ZNF714_ENST00000596053.1_Intron|ZNF714_ENST00000601416.1_3'UTR|ZNF714_ENST00000291770.7_3'UTR	NM_182515.3	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	183					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|urinary_tract(2)	18						AAGTGTTTAAGCGGTTCTCAA	0.368000													8	95					0	0	1	0	0
ATP6V1G3	127124	broad.mit.edu	37	1	198505855	198505855	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:198505855C>G	ENST00000309309.7	-	3	188		c.e3-1		ATP6V1G3_ENST00000367381.1_Intron|ATP6V1G3_ENST00000367382.1_Intron|ATP6V1G3_ENST00000489986.1_Intron|ATP6V1G3_ENST00000281087.2_Intron	NM_133326.1	NP_579872.1	Q96LB4	VATG3_HUMAN	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3						cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)	7						AGATGCAGAACTTACAGCAGG	0.333000													10	99					0	0	1	0	0
ACTG1	71	broad.mit.edu	37	17	79478100	79478100	+	Silent	SNP	G	G	A	rs77274428		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:79478100G>A	ENST00000575842.1	-	4	1263	c.837C>T	c.(835-837)ttC>ttT	p.F279F	ACTG1_ENST00000331925.2_Silent_p.F279F|ACTG1_ENST00000575087.1_Silent_p.F279F|AC139149.1_ENST00000584254.1_RNA|ACTG1_ENST00000573283.1_Silent_p.F279F			P63261	ACTG_HUMAN	actin, gamma 1	279					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|lung(8)|ovary(2)|prostate(5)|urinary_tract(1)	29	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			TGATGGAGTTGAAGGTGGTCT	0.557000													37	86					0	0	1	0	0
TMEM219	124446	broad.mit.edu	37	16	29979543	29979543	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:29979543G>A	ENST00000566848.1	+	3	1020	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	TMEM219_ENST00000561899.2_Missense_Mutation_p.E185K|TMEM219_ENST00000414689.2_Missense_Mutation_p.E185K|TMEM219_ENST00000279396.6_Missense_Mutation_p.E185K			Q86XT9	TM219_HUMAN	transmembrane protein 219	185						integral to membrane				large_intestine(1)|lung(1)|prostate(2)	4						CTGGAGCCATGAAGGCCTTGT	0.567000													17	73					0	0	1	0	0
DNAI2	64446	broad.mit.edu	37	17	72308166	72308166	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:72308166G>A	ENST00000579490.1	+	11	1825	c.1690G>A	c.(1690-1692)Gag>Aag	p.E564K	DNAI2_ENST00000446837.2_Missense_Mutation_p.E507K|DNAI2_ENST00000582036.1_Missense_Mutation_p.E495K|DNAI2_ENST00000307504.5_Missense_Mutation_p.E364K|DNAI2_ENST00000311014.6_Missense_Mutation_p.E507K			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2	507					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GACCCGGCGAGAGAAGATCCT	0.652000									Kartagener syndrome				4	39					0	0	1	0	0
ZNF732	654254	broad.mit.edu	37	4	266334	266334	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:266334C>G	ENST00000419098.1	-	4	322	c.312G>C	c.(310-312)gaG>gaC	p.E104D		NM_001137608.1	NP_001131080.1	B4DXR9	ZN732_HUMAN	zinc finger protein 732	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(2)	3						GTCCACATTTCTCATATCTTC	0.343000													4	9					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160289269	160289269	+	Splice_Site	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:160289269T>C	ENST00000392783.2	-	9	2394	c.1899A>G	c.(1897-1899)tcA>tcG	p.S633S	BAZ2B_ENST00000355831.2_Splice_Site_p.S633S|BAZ2B_ENST00000343439.5_Splice_Site_p.S631S|BAZ2B_ENST00000392782.1_Splice_Site_p.S631S	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	633	Asp/Glu-rich (acidic).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						GAAAATAACCTGATTGGCTGT	0.308000													3	38					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52524266	52524266	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr13:52524266T>C	ENST00000242839.4	-	11	2763	c.2607A>G	c.(2605-2607)ggA>ggG	p.G869G	ATP7B_ENST00000344297.5_Silent_p.G707G|ATP7B_ENST00000400370.3_Silent_p.G439G|ATP7B_ENST00000448424.2_Silent_p.G791G|ATP7B_ENST00000400366.3_Silent_p.G758G|ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000418097.2_Silent_p.G869G|ATP7B_ENST00000417240.2_Silent_p.G141G	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	869			G -> R (in WD).|G -> V (in WD).		ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TTACAGTGCTTCCGGGTTTCT	0.507000									Wilson disease				3	45					0	0	1	0	0
FKBP4	2288	broad.mit.edu	37	12	2907949	2907949	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:2907949C>T	ENST00000001008.4	+	4	658	c.471C>T	c.(469-471)cgC>cgT	p.R157R	RP4-816N1.6_ENST00000547834.1_RNA|RP4-816N1.7_ENST00000547042.1_RNA	NM_002014.3	NP_002005.1	Q02790	FKBP4_HUMAN	FK506 binding protein 4, 59kDa	157					negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(1)	14			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	TACAGACTCGCGGTGAAGGCT	0.483000													5	55					0	0	1	0	0
FOXN2	3344	broad.mit.edu	37	2	48602108	48602108	+	Silent	SNP	C	C	T	rs144420824	by1000genomes	TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:48602108C>T	ENST00000340553.3	+	7	1083	c.822C>T	c.(820-822)taC>taT	p.Y274Y		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	274					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			AGAGGAGTTACGGCAATGCAT	0.388000													4	39					0	0	1	0	0
ELP2	55250	broad.mit.edu	37	18	33754520	33754520	+	Silent	SNP	A	A	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:33754520A>C	ENST00000358232.6	+	22	2460	c.2397A>C	c.(2395-2397)gcA>gcC	p.A799A	ELP2_ENST00000423854.2_Silent_p.A729A|ELP2_ENST00000351393.6_Silent_p.A773A|ELP2_ENST00000350494.6_Silent_p.A794A|ELP2_ENST00000542824.1_Silent_p.A729A|ELP2_ENST00000442325.2_Silent_p.A864A	NM_018255.2	NP_060725.1	Q6IA86	ELP2_HUMAN	elongator acetyltransferase complex subunit 2	799					regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				NS(1)|breast(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|urinary_tract(2)	30						AGAAGGAAGCAGAAGGTGCTG	0.383000													13	31					0	0	1	0	0
D2HGDH	728294	broad.mit.edu	37	2	242681915	242681915	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:242681915G>A	ENST00000321264.4	+	4	625	c.416G>A	c.(415-417)aGc>aAc	p.S139N	D2HGDH_ENST00000342518.6_Missense_Mutation_p.S139N|D2HGDH_ENST00000537090.1_Missense_Mutation_p.S139N|D2HGDH_ENST00000403782.1_Missense_Mutation_p.S5N	NM_152783.3	NP_689996.4	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase	139	FAD-binding PCMH-type.				2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding			breast(1)|endometrium(3)|lung(10)|skin(1)|urinary_tract(1)	16		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GTGGGTGGCAGCGTCCCCGTC	0.647000													6	39					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44596230	44596230	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:44596230C>A	ENST00000372299.3	+	3	1030	c.972C>A	c.(970-972)ttC>ttA	p.F324L	KLF17_ENST00000476802.1_3'UTR	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	324					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					CATGGTCTTTCTTCCGTTCTG	0.468000													21	84					6.33239e-15	7.47877e-15	1	1	0
PLK3	1263	broad.mit.edu	37	1	45271311	45271311	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:45271311C>A	ENST00000372201.4	+	15	2141	c.1902C>A	c.(1900-1902)cgC>cgA	p.R634R	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	634	POLO box 2.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					AGCGACTCCGCTATGCTCTGC	0.637000													6	62					0.00116845	0.0012201	1	1	0
ZNF609	23060	broad.mit.edu	37	15	64966179	64966179	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:64966179C>T	ENST00000326648.3	+	4	1254	c.1126C>T	c.(1126-1128)Cgt>Tgt	p.R376C	ZNF609_ENST00000559364.1_3'UTR	NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	376						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CAAACGCATGCGTCCCAACAG	0.512000													6	112					0	0	1	0	0
PITPNC1	26207	broad.mit.edu	37	17	65688747	65688747	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:65688747A>T	ENST00000335257.6	+	9	1089	c.742A>T	c.(742-744)Aaa>Taa	p.K248*	PITPNC1_ENST00000581322.1_Nonsense_Mutation_p.K248*|PITPNC1_ENST00000580974.1_3'UTR|PITPNC1_ENST00000299954.9_3'UTR			Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein, cytoplasmic 1	248					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			breast(1)|kidney(2)|large_intestine(3)|liver(2)|lung(4)|prostate(2)|skin(3)	17	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			CACCAACAAGAAAATCGGCAT	0.483000													4	89					0	0	1	0	0
FBXL12	54850	broad.mit.edu	37	19	9922216	9922216	+	Missense_Mutation	SNP	C	C	A	rs145046400		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:9922216C>A	ENST00000247977.4	-	3	578	c.337G>T	c.(337-339)Gac>Tac	p.D113Y	FBXL12_ENST00000589626.1_3'UTR|FBXL12_ENST00000585379.1_Missense_Mutation_p.D60Y|FBXL12_ENST00000588922.1_3'UTR|FBXL12_ENST00000586651.1_3'UTR|FBXL12_ENST00000592067.1_3'UTR|FBXL12_ENST00000591009.1_Missense_Mutation_p.D60Y	NM_017703.1	NP_060173.1	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12	113							protein binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(2)	10						ATGCTCAGGTCGGCCACGTGC	0.652000													15	99					1.15088e-07	1.30306e-07	1	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76350421	76350421	+	Splice_Site	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:76350421G>T	ENST00000307431.8	+	3	578		c.e3+1		CNTNAP4_ENST00000469589.1_Splice_Site|CNTNAP4_ENST00000478060.1_Splice_Site|CNTNAP4_ENST00000377504.4_Splice_Site|CNTNAP4_ENST00000476707.1_Splice_Site	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4						cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AGAAGAGATGGTAAGTCTGCT	0.433000													6	16					3.59834e-05	3.9001e-05	1	1	0
SPPL3	121665	broad.mit.edu	37	12	121248685	121248685	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:121248685A>G	ENST00000353487.2	-	2	531	c.28T>C	c.(28-30)Tat>Cat	p.Y10H		NM_139015.4	NP_620584.2	Q8TCT6	PSL4_HUMAN	signal peptide peptidase like 3	10						integral to membrane	aspartic-type endopeptidase activity					all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ACCAGGGAATAGGCCCTAGAG	0.378000													21	82					0	0	1	0	0
NBPF12	149013	broad.mit.edu	37	1	146466002	146466002	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:146466002T>A	ENST00000442909.2	+	82	10713	c.9877T>A	c.(9877-9879)Ttt>Att	p.F3293I	NBPF12_ENST00000309471.8_3'UTR|NBPF12_ENST00000446760.2_3'UTR					neuroblastoma breakpoint family, member 12											ovary(2)	2						CAGAAGTGTGTTTTACTCATT	0.448000													19	202					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179439394	179439394	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:179439394T>C	ENST00000589042.1	-	326	71689	c.71465A>G	c.(71464-71466)tAt>tGt	p.Y23822C	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.Y14882C|TTN_ENST00000460472.2_Missense_Mutation_p.Y14757C|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.Y14949C|TTN_ENST00000591111.1_Missense_Mutation_p.Y22181C|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.Y21254C|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22181	Fibronectin type-III 73.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTAAATGGATAGTTGGCAAC	0.463000													13	64					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67649690	67649690	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:67649690C>T	ENST00000335894.4	+	7	711	c.645C>T	c.(643-645)ttC>ttT	p.F215F	IQCH_ENST00000358767.3_Silent_p.F42F|IQCH_ENST00000546225.1_5'UTR	NM_001031715.2	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H	215										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		CAGCCACTTTCACTATACCTC	0.408000													7	29					0	0	1	0	0
UCKL1	54963	broad.mit.edu	37	20	62577212	62577212	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:62577212C>A	ENST00000369908.5	-	4	782	c.483G>T	c.(481-483)aaG>aaT	p.K161N	UCKL1_ENST00000358711.3_Missense_Mutation_p.K176N|UCKL1_ENST00000354216.6_Missense_Mutation_p.K176N|UCKL1_ENST00000492660.1_5'UTR|UCKL1_ENST00000369892.3_Missense_Mutation_p.K176N	NM_001193379.1	NP_001180308.1	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	176					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity			endometrium(3)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CCTTGACACTCTTCCCCTGCT	0.582000													31	150					2.46105e-21	2.94724e-21	1	1	0
TRAK2	66008	broad.mit.edu	37	2	202260126	202260126	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:202260126A>C	ENST00000332624.3	-	8	1239	c.811T>G	c.(811-813)Tca>Gca	p.S271A	TRAK2_ENST00000430254.1_Missense_Mutation_p.S271A	NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	271						early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						CTCTTCCCTGACAATTCTTCA	0.358000													16	113					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43292282	43292282	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:43292282C>T	ENST00000374518.5	+	10	1653	c.1590C>T	c.(1588-1590)tgC>tgT	p.C530C		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor						ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AAGAGGACTGCACTGCAGGAG	0.522000													6	38					0	0	1	0	0
AIFM2	84883	broad.mit.edu	37	10	71876426	71876426	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:71876426G>C	ENST00000307864.1	-	7	934	c.721C>G	c.(721-723)Ctc>Gtc	p.L241V	AIFM2_ENST00000373248.1_Missense_Mutation_p.L241V|AIFM2_ENST00000482166.1_5'UTR	NM_001198696.1|NM_032797.5	NP_001185625.1|NP_116186.1	Q9BRQ8	AIFM2_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 2	241					apoptotic mitochondrial changes|chromosome condensation|induction of apoptosis	cytosol|integral to membrane|mitochondrial outer membrane	DNA binding|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|urinary_tract(2)	16						CCGGTGCAGAGAATCACCAGG	0.582000											OREG0020234	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	64					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768114	57768114	+	Silent	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:57768114C>G	ENST00000371030.2	+	1	2040	c.2040C>G	c.(2038-2040)gtC>gtG	p.V680V		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	680						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GGACCCCTGTCCATGAGGACA	0.617000													3	27					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151829821	151829821	+	Silent	SNP	G	G	C	rs143448521		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:151829821G>C	ENST00000535741.1	-	10	1823	c.1350C>G	c.(1348-1350)ctC>ctG	p.L450L	LRBA_ENST00000510413.1_Silent_p.L450L|LRBA_ENST00000357115.3_Silent_p.L450L|LRBA_ENST00000507224.1_Silent_p.L450L			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	450						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					CCTGGAGCATGAGTGCATGTG	0.378000													14	69					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54806528	54806528	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:54806528C>T	ENST00000306858.7	+	5	2875	c.2759C>T	c.(2758-2760)tCc>tTc	p.S920F		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	920										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AGGCCAACGTCCAGTGAGCTT	0.438000													7	71					0	0	1	0	0
DDT	1652	broad.mit.edu	37	22	24313771	24313771	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:24313771C>T	ENST00000404092.1	-	5	600	c.368G>A	c.(367-369)gGc>gAc	p.G123D	DDTL_ENST00000215770.5_3'UTR|DDT_ENST00000350608.3_Missense_Mutation_p.G109D|DDT_ENST00000398344.4_Missense_Mutation_p.G109D			P30046	DOPD_HUMAN	D-dopachrome tautomerase	109					melanin biosynthetic process	cytoplasm	D-dopachrome decarboxylase activity|dopachrome isomerase activity|protein binding										CCCTATCTTGCCAATCTGCCA	0.483000													4	55					0	0	1	0	0
USP37	57695	broad.mit.edu	37	2	219423304	219423304	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:219423304C>A	ENST00000258399.3	-	4	485	c.73G>T	c.(73-75)Gga>Tga	p.G25*	USP37_ENST00000338465.5_Nonsense_Mutation_p.G25*|USP37_ENST00000418019.1_Nonsense_Mutation_p.G25*|USP37_ENST00000415516.1_Intron|USP37_ENST00000454775.1_Nonsense_Mutation_p.G25*	NM_020935.2	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	25					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TCAAAGGATCCTTCTTTCCAC	0.348000													6	173					8.12818e-05	8.6997e-05	1	1	0
HIVEP3	59269	broad.mit.edu	37	1	42041253	42041253	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:42041253C>T	ENST00000372584.1	-	4	6183	c.5169G>A	c.(5167-5169)caG>caA	p.Q1723Q	HIVEP3_ENST00000247584.5_Silent_p.Q1723Q|HIVEP3_ENST00000429157.2_Silent_p.Q1723Q|HIVEP3_ENST00000372583.1_Silent_p.Q1723Q|HIVEP3_ENST00000460604.1_5'UTR	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1723					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GCTCCCCTCTCTGGGAGGCAG	0.552000													5	172					0	0	1	0	0
FNBP1	23048	broad.mit.edu	37	9	132686250	132686250	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:132686250G>C	ENST00000420781.1	-	10	1231	c.1013C>G	c.(1012-1014)gCc>gGc	p.A338G	FNBP1_ENST00000446176.2_Missense_Mutation_p.A348G|FNBP1_ENST00000355681.3_Intron|FNBP1_ENST00000478129.1_Intron			Q96RU3	FNBP1_HUMAN	formin binding protein 1	348	Required for self-association and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding						Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		Agagggtgaggcagaggcagg	0.537000			T	MLL	AML								4	10					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38770982	38770982	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:38770982C>G	ENST00000359357.3	+	20	2532	c.2278C>G	c.(2278-2280)Cta>Gta	p.L760V	DNAH8_ENST00000441566.1_Missense_Mutation_p.L760V|DNAH8_ENST00000449981.2_Missense_Mutation_p.L977V					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GGCTGACATTCTAAACCACAA	0.318000													8	42					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25470279	25470279	+	RNA	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:25470279C>A	ENST00000453082.2	+	0	1047					NR_003343.1																						CCCTGGTCTCCTGCACTGAGC	0.562000													10	67					2.17888e-05	2.38043e-05	1	1	0
LPCAT3	10162	broad.mit.edu	37	12	7086336	7086336	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:7086336C>A	ENST00000261407.4	-	12	1521	c.1436G>T	c.(1435-1437)aGg>aTg	p.R479M	LPCAT3_ENST00000535021.1_5'UTR	NM_005768.5	NP_005759.4	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	479					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	17						CTTCTCTTTCCTTGGCACCAT	0.393000													16	50					2.31682e-05	2.52309e-05	1	1	0
FAM86A	196483	broad.mit.edu	37	16	5145470	5145470	+	Missense_Mutation	SNP	G	G	A	rs143508087		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:5145470G>A	ENST00000427587.4	-	2	210	c.142C>T	c.(142-144)Cgg>Tgg	p.R48W	FAM86A_ENST00000587133.1_Missense_Mutation_p.R48W|FAM86A_ENST00000458008.4_Missense_Mutation_p.R48W	NM_201400.2	NP_958802.1	Q96G04	FA86A_HUMAN	family with sequence similarity 86, member A	48								p.R48W(1)		endometrium(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	12						AAAATATCCCGCAGCAGCTCA	0.488000													17	96					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35873689	35873689	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:35873689G>C	ENST00000314607.6	+	26	3957	c.3877G>C	c.(3877-3879)Gag>Cag	p.E1293Q	ZMYM4_ENST00000373297.2_Missense_Mutation_p.E1204Q	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	1293					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTTTATCCAAGAGGTGCGGAG	0.408000													7	141					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70098687	70098687	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:70098687G>T	ENST00000370598.1	+	32	5294	c.4473G>T	c.(4471-4473)gaG>gaT	p.E1491D	BAI3_ENST00000238918.8_Missense_Mutation_p.E697D|BAI3_ENST00000546190.1_Missense_Mutation_p.E455D	NM_001704.2	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1491					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				TAGACACAGAGGCAAAGGATG	0.453000													5	31					0.00116845	0.0012201	1	1	0
RTF1	23168	broad.mit.edu	37	15	41771355	41771355	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:41771355G>A	ENST00000389629.4	+	16	1885	c.1873G>A	c.(1873-1875)Ggt>Agt	p.G625S		NM_015138.4	NP_055953.3	Q92541	RTF1_HUMAN	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	625					histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	18		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		TGCAAAATACGGTTCTGGAGT	0.493000													14	68					0	0	1	0	0
RCBTB2	1102	broad.mit.edu	37	13	49075883	49075883	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr13:49075883C>A	ENST00000344532.3	-	12	1662	c.1239G>T	c.(1237-1239)aaG>aaT	p.K413N	RCBTB2_ENST00000430805.2_Missense_Mutation_p.K418N|RCBTB2_ENST00000544492.1_Missense_Mutation_p.K139N	NM_001268.2	NP_001259.1	O95199	RCBT2_HUMAN	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	413	BTB 1.						Ran guanyl-nucleotide exchange factor activity			breast(5)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(3)	31		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		CTTACCGAATCTTGAGAAGGA	0.368000													5	45					3.59834e-05	3.9001e-05	1	1	0
RNF2	6045	broad.mit.edu	37	1	185069351	185069351	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:185069351C>T	ENST00000367510.3	+	7	1217	c.929C>T	c.(928-930)tCt>tTt	p.S310F	RNF2_ENST00000367509.4_Missense_Mutation_p.S238F	NM_007212.3	NP_009143.1	Q99496	RING2_HUMAN	ring finger protein 2	310					histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(3)|endometrium(2)|large_intestine(4)|lung(3)|skin(2)	14		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		GGCTCTTTTTCTTTGGAATTG	0.323000													18	87					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48695694	48695694	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:48695694G>A	ENST00000352832.5	+	30	5687	c.5315G>A	c.(5314-5316)gGc>gAc	p.G1772D	CACNA1G_ENST00000514079.1_Missense_Mutation_p.G1813D|CACNA1G_ENST00000507510.2_Missense_Mutation_p.G1806D|CACNA1G_ENST00000442258.2_Missense_Mutation_p.G1765D|CACNA1G_ENST00000507609.1_Missense_Mutation_p.G1799D|CACNA1G_ENST00000505165.1_Missense_Mutation_p.G1806D|CACNA1G_ENST00000513689.2_Missense_Mutation_p.G1761D|CACNA1G_ENST00000514181.1_Missense_Mutation_p.G1781D|CACNA1G_ENST00000507336.1_Missense_Mutation_p.G1795D|CACNA1G_ENST00000512389.1_Missense_Mutation_p.G1795D|CACNA1G_ENST00000510366.1_Missense_Mutation_p.G1754D|CACNA1G_ENST00000359106.5_Missense_Mutation_p.G1806D|CACNA1G_ENST00000510115.1_Missense_Mutation_p.G1772D|CACNA1G_ENST00000515765.1_Missense_Mutation_p.G1795D|CACNA1G_ENST00000507896.1_Missense_Mutation_p.G1795D|CACNA1G_ENST00000503485.1_Missense_Mutation_p.G1772D|CACNA1G_ENST00000354983.4_Missense_Mutation_p.G1772D|CACNA1G_ENST00000515411.1_Missense_Mutation_p.G1788D|CACNA1G_ENST00000502264.1_Missense_Mutation_p.G1783D|CACNA1G_ENST00000514717.1_Missense_Mutation_p.G1749D|CACNA1G_ENST00000429973.2_Missense_Mutation_p.G1788D|CACNA1G_ENST00000513964.1_Missense_Mutation_p.G1761D|CACNA1G_ENST00000360761.4_Missense_Mutation_p.G1783D|CACNA1G_ENST00000358244.5_Missense_Mutation_p.G1772D|CACNA1G_ENST00000515165.1_Missense_Mutation_p.G1806D	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1806					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	AATTGGAATGGCATTATGAAG	0.552000													10	71					0	0	1	0	0
CHML	1122	broad.mit.edu	37	1	241798343	241798343	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:241798343T>C	ENST00000366553.1	-	1	889	c.726A>G	c.(724-726)ggA>ggG	p.G242G	OPN3_ENST00000469376.1_Intron|OPN3_ENST00000366554.2_Intron|OPN3_ENST00000331838.5_Intron	NM_001821.3	NP_001812.2	P26374	RAE2_HUMAN	choroideremia-like (Rab escort protein 2)	242					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(4)|skin(3)|stomach(1)	26	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CAATTAGCAATCCTTGAGAAT	0.333000													3	54					0	0	1	0	0
SYNGR4	23546	broad.mit.edu	37	19	48879560	48879560	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:48879560G>A	ENST00000344846.2	+	5	940	c.690G>A	c.(688-690)atG>atA	p.M230I	SYNGR4_ENST00000601610.1_3'UTR	NM_012451.3	NP_036583.2	O95473	SNG4_HUMAN	synaptogyrin 4	230						integral to membrane				breast(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_epithelial(76;5.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|Prostate(7;0.0143)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		GGCTTGCTATGATGCCTGACA	0.517000													8	26					0	0	1	0	0
TMEM252	169693	broad.mit.edu	37	9	71155530	71155530	+	Silent	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:71155530A>G	ENST00000377311.3	-	1	253	c.201T>C	c.(199-201)acT>acC	p.T67T		NM_153237.1	NP_694969.1			transmembrane protein 252																		CTTTGCTTTCAGTCACCTGGC	0.557000													6	27					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849558	98849558	+	RNA	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:98849558G>T	ENST00000554295.1	-	0	1365					NR_033801.1																						GCTCTGCCCAGGAAGACAGCA	0.478000													10	40					0.00621372	0.00641023	1	1	0
ADH1A	124	broad.mit.edu	37	4	100200705	100200705	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:100200705T>A	ENST00000209668.2	-	8	1094	c.981A>T	c.(979-981)gaA>gaT	p.E327D	RP11-696N14.1_ENST00000506160.1_RNA|RP11-696N14.1_ENST00000500358.2_RNA	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	327					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	TTGGGACACATTCTTTACTTT	0.313000													6	112					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43316397	43316397	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:43316397G>C	ENST00000331495.3	+	11	1381	c.1045G>C	c.(1045-1047)Gag>Cag	p.E349Q	FMNL1_ENST00000592006.1_3'UTR|FMNL1_ENST00000328118.3_Missense_Mutation_p.E349Q|CTD-2020K17.3_ENST00000587534.1_RNA	NM_005892.3	NP_005883	O95466	FMNL_HUMAN	formin-like 1	349	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						CCTGCAATATGAGTTCACCCA	0.552000													3	69					0	0	1	0	0
C19orf10	56005	broad.mit.edu	37	19	4668610	4668610	+	Silent	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:4668610A>G	ENST00000262947.3	-	2	257	c.222T>C	c.(220-222)aaT>aaC	p.N74N	C19orf10_ENST00000599630.1_Silent_p.N74N	NM_019107.3	NP_061980.1	Q969H8	CS010_HUMAN	chromosome 19 open reading frame 10	74						ER-Golgi intermediate compartment|extracellular region				haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.015)		AACTCACCTCATTGGTCCCTC	0.403000													4	43					0	0	1	0	0
SOX9	6662	broad.mit.edu	37	17	70119709	70119709	+	Silent	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:70119709A>G	ENST00000245479.2	+	3	1083	c.711A>G	c.(709-711)ccA>ccG	p.P237P		NM_000346.3	NP_000337.1	P48436	SOX9_HUMAN	SRY (sex determining region Y)-box 9	237					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(5)|pancreas(1)|upper_aerodigestive_tract(2)	26		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			CACCGACCCCACCCACCACCC	0.627000													20	128					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44592115	44592115	+	Silent	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:44592115G>C	ENST00000322927.2	-	9	1630	c.1530C>G	c.(1528-1530)ctC>ctG	p.L510L	ZNF335_ENST00000426788.1_Silent_p.L355L	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	510					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				CCCGCACCTTGAGCGAGGACC	0.612000													9	54					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154157487	154157487	+	Silent	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:154157487A>G	ENST00000360256.4	-	14	4778	c.4578T>C	c.(4576-4578)ccT>ccC	p.P1526P		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1526	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TAGTTTCCGTAGGGAATAGGT	0.468000													29	62					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113303575	113303575	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:113303575G>C	ENST00000264852.4	+	8	1592	c.866G>C	c.(865-867)cGa>cCa	p.R289P	SIDT1_ENST00000393830.3_Missense_Mutation_p.R289P	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	289						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						AATCTACAGCGAAAAAAGAAC	0.353000													24	68					0	0	1	0	0
C9orf171	389799	broad.mit.edu	37	9	135374932	135374932	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:135374932A>G	ENST00000343036.2	+	4	625	c.577A>G	c.(577-579)Atg>Gtg	p.M193V	C9orf171_ENST00000393215.3_Missense_Mutation_p.M157V|C9orf171_ENST00000393216.2_Missense_Mutation_p.M157V	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	193										large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						TGACCGGCGCATGAAGAAAGA	0.622000													32	57					0	0	1	0	0
ACTBL2	345651	broad.mit.edu	37	5	56777857	56777857	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:56777857C>A	ENST00000423391.1	-	1	779	c.678G>T	c.(676-678)caG>caT	p.Q226H	CTD-2023N9.1_ENST00000506106.1_RNA	NM_001017992.3	NP_001017992.1	Q562R1	ACTBL_HUMAN	actin, beta-like 2	226						cytoplasm|cytoskeleton	ATP binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(3)|pancreas(1)|prostate(2)	28		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		TGACCATCTCCTGCTCAAAGT	0.557000													7	51					3.09899e-07	3.46298e-07	1	1	0
SERAC1	84947	broad.mit.edu	37	6	158549208	158549208	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:158549208C>T	ENST00000367102.2	-	10	1088	c.947G>A	c.(946-948)aGa>aAa	p.R316K	SERAC1_ENST00000367101.1_Missense_Mutation_p.R316K|SERAC1_ENST00000367104.3_Missense_Mutation_p.R316K			Q96JX3	SRAC1_HUMAN	serine active site containing 1	316					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds			endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	15		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		CATTATATTTCTCTGTACTTT	0.393000													10	60					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	95993700	95993700	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:95993700A>G	ENST00000324765.8	+	3	628	c.281A>G	c.(280-282)tAt>tGt	p.Y94C	DIAPH2_ENST00000373054.4_Missense_Mutation_p.Y83C|DIAPH2_ENST00000373049.4_Missense_Mutation_p.Y94C|DIAPH2_ENST00000355827.4_Missense_Mutation_p.Y94C|DIAPH2_ENST00000373061.3_Missense_Mutation_p.Y94C			O60879	DIAP2_HUMAN	diaphanous-related formin 2	94					cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						CAGCCATTATATGATGAACGA	0.318000													12	31					0	0	1	0	0
PDE6C	5146	broad.mit.edu	37	10	95372703	95372703	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:95372703G>A	ENST00000371447.3	+	1	359	c.221G>A	c.(220-222)gGc>gAc	p.G74D		NM_006204.3	NP_006195.3	P51160	PDE6C_HUMAN	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	74					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.123)				GAGGAGGGGGGCACCCCAGAG	0.662000													6	35					0	0	1	0	0
TCEB3	6924	broad.mit.edu	37	1	24077835	24077835	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:24077835C>G	ENST00000418390.2	+	4	1089	c.818C>G	c.(817-819)tCt>tGt	p.S273C	TCEB3_ENST00000609199.1_Missense_Mutation_p.S247C	NM_003198.2	NP_003189.2	Q14241	ELOA1_HUMAN	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)	273					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		GAGCACAAATCTTCCCACAAG	0.542000											OREG0013232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	57					0	0	1	0	0
CASP2	835	broad.mit.edu	37	7	143000971	143000971	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:143000971G>A	ENST00000310447.5	+	9	1303	c.1062G>A	c.(1060-1062)ccG>ccA	p.P354P	CASP2_ENST00000493642.1_3'UTR	NM_032982.3|NM_032983.3	NP_116764.2|NP_116765.2	P42575	CASP2_HUMAN	caspase 2, apoptosis-related cysteine peptidase	354					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(164;0.059)					AAAAGTTGCCGAAGATGAGAC	0.498000													4	14					0	0	1	0	0
OR51A7	119687	broad.mit.edu	37	11	4929160	4929160	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:4929160G>A	ENST00000359350.4	+	1	561	c.561G>A	c.(559-561)ctG>ctA	p.L187L	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	187					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCATGAAGCTGGCCTGCTCTG	0.398000													10	119					0	0	1	0	0
KIT	3815	broad.mit.edu	37	4	55597512	55597512	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:55597512G>T	ENST00000288135.5	+	15	2257	c.2160G>T	c.(2158-2160)gaG>gaT	p.E720D		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	720	Protein kinase.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GTACTAATGAGTACATGGACA	0.458000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				7	37					3.09899e-07	3.46298e-07	1	1	0
CPZ	8532	broad.mit.edu	37	4	8613821	8613821	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:8613821G>A	ENST00000429646.2	+	6	2912	c.119G>A	c.(118-120)aGg>aAg	p.R40K	CPZ_ENST00000382480.2_Missense_Mutation_p.R295K|CPZ_ENST00000315782.6_Missense_Mutation_p.R421K|CPZ_ENST00000360986.4_Missense_Mutation_p.R432K			Q66K79	CBPZ_HUMAN	carboxypeptidase Z	432	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						TCGGAGAATAGGTGTGGAGGC	0.587000													3	16					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156346536	156346536	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:156346536C>T	ENST00000274532.2	-	9	1125	c.1069G>A	c.(1069-1071)Gat>Aat	p.D357N	TIMD4_ENST00000406964.1_Missense_Mutation_p.D59N|TIMD4_ENST00000407087.3_Missense_Mutation_p.D329N	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	357						integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTTTTACTATCTCCAATGTAG	0.428000													9	56					0	0	1	0	0
CDC14B	8555	broad.mit.edu	37	9	99266040	99266040	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:99266040G>A	ENST00000375241.1	-	14	1943	c.1492C>T	c.(1492-1494)Cgt>Tgt	p.R498C	CDC14B_ENST00000463569.1_3'UTR|CDC14B_ENST00000375240.3_Missense_Mutation_p.R459C|CDC14B_ENST00000265659.2_Intron|CDC14B_ENST00000375242.3_Missense_Mutation_p.R461C	NM_003671.3|NM_033331.2	NP_003662.1|NP_201588.1	O60729	CC14B_HUMAN	cell division cycle 14B	498					activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)	15		Acute lymphoblastic leukemia(62;0.0559)				TTTACTTAACGCAAGACTGTT	0.383000													7	77					0	0	1	0	0
OAZ3	51686	broad.mit.edu	37	1	151740664	151740664	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:151740664T>C	ENST00000321531.5	+	4	466	c.299T>C	c.(298-300)tTc>tCc	p.F100S	RP11-98D18.3_ENST00000512280.1_RNA|OAZ3_ENST00000479764.1_Intron|OAZ3_ENST00000453029.2_Missense_Mutation_p.F113S|OAZ3_ENST00000400999.1_5'UTR|OAZ3_ENST00000315067.8_Missense_Mutation_p.F100S			Q9UMX2	OAZ3_HUMAN	ornithine decarboxylase antizyme 3	97					cellular nitrogen compound metabolic process|regulation of cellular amino acid metabolic process|spermatogenesis	cytosol|nucleus	ornithine decarboxylase inhibitor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)	9	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)		L-Ornithine(DB00129)	CGTCGACTCTTCTTGGATATC	0.557000													4	25					0	0	1	0	0
TLK2	11011	broad.mit.edu	37	17	60663572	60663572	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:60663572A>G	ENST00000582809.1	+	17	1701	c.998A>G	c.(997-999)aAg>aGg	p.K333R	TLK2_ENST00000542523.1_Missense_Mutation_p.K450R|TLK2_ENST00000343388.7_Missense_Mutation_p.K450R|TLK2_ENST00000346027.5_Missense_Mutation_p.K482R|TLK2_ENST00000326270.9_Missense_Mutation_p.K504R			Q86UE8	TLK2_HUMAN	tousled-like kinase 2	504					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						GATGAGAAAAAGGAGAATTAC	0.313000													6	44					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579324	7579324	+	Silent	SNP	A	A	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:7579324A>T	ENST00000420246.2	-	4	495	c.363T>A	c.(361-363)tcT>tcA	p.S121S	TP53_ENST00000413465.2_Silent_p.S121S|TP53_ENST00000269305.4_Silent_p.S121S|TP53_ENST00000445888.2_Silent_p.S121S|TP53_ENST00000455263.2_Silent_p.S121S|TP53_ENST00000359597.4_Silent_p.S121S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	121	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		S -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.G59fs*23(3)|p.S121fs*27(1)|p.V73fs*9(1)|p.G105_T125del21(1)|p.G112_V122delGFLHSGTAKSV(1)|p.V122fs*46(1)|p.Y107fs*44(1)|p.P13fs*18(1)|p.S33fs*23(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCAAGTCACAGACTTGGCTG	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	35					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34100906	34100906	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:34100906A>G	ENST00000538487.2	-	2	811	c.368T>C	c.(367-369)gTg>gCg	p.V123A	GRM4_ENST00000374181.4_Missense_Mutation_p.V123A|GRM4_ENST00000374177.3_Intron	NM_000841.2|NM_001256811.1	NP_000832.1|NP_001243740.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4						activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	GAGCGCCTGCACAAAGGTCAG	0.627000													4	21					0	0	1	0	0
ABHD8	79575	broad.mit.edu	37	19	17411732	17411732	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:17411732C>G	ENST00000247706.3	-	2	933	c.694G>C	c.(694-696)Gag>Cag	p.E232Q	MRPL34_ENST00000600434.1_Intron|MRPL34_ENST00000595444.1_Intron	NM_024527.4	NP_078803.4	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	232							hydrolase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)|urinary_tract(1)	9						CGCATGTCCTCAGCCAGCGCA	0.617000													22	98					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42165058	42165058	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:42165058C>T	ENST00000444063.1	+	16	1995	c.1863C>T	c.(1861-1863)cgC>cgT	p.R621R	L3MBTL1_ENST00000373134.1_Silent_p.R626R|L3MBTL1_ENST00000418998.1_Silent_p.R689R|L3MBTL1_ENST00000373135.3_Silent_p.R621R|L3MBTL1_ENST00000427442.2_Silent_p.R689R			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	621					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						GAATTGGACGCCCTCCGAAGT	0.562000													14	50					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89522729	89522729	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:89522729C>G	ENST00000370473.4	-	7	1182	c.963G>C	c.(961-963)caG>caC	p.Q321H		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	321					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		AGTTCTCTATCTGGGCCAAGG	0.567000													15	65					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10699863	10699863	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:10699863C>T	ENST00000377022.3	-	21	4733	c.4416G>A	c.(4414-4416)acG>acA	p.T1472T	RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.2	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	1472					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TGTACATGTGCGTGCGCCCGC	0.602000													4	11					0	0	1	0	0
EBP	10682	broad.mit.edu	37	X	48382311	48382311	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:48382311G>T	ENST00000495186.1	+	2	975	c.152G>T	c.(151-153)gGt>gTt	p.G51V	EBP_ENST00000276096.6_3'UTR	NM_006579.2	NP_006570.1	Q15125	EBP_HUMAN	emopamil binding protein (sterol isomerase)	51					cholesterol biosynthetic process|skeletal system development	endoplasmic reticulum membrane|integral to plasma membrane	cholestenol delta-isomerase activity|drug transmembrane transporter activity|steroid delta-isomerase activity|transmembrane receptor activity			NS(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|stomach(1)	11						CTGTTGTCAGGTCGTGCTGCG	0.567000													15	45					0.000308642	0.000327783	1	1	0
MUC1	4582	broad.mit.edu	37	1	155160660	155160660	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:155160660C>T	ENST00000368398.3	-	3	211	c.188G>A	c.(187-189)tGc>tAc	p.C63Y	MUC1_ENST00000368395.1_Silent_p.L289L|MUC1_ENST00000457295.2_Silent_p.L78L|MUC1_ENST00000343256.5_Missense_Mutation_p.C63Y|MUC1_ENST00000368390.3_Silent_p.L69L|MUC1_ENST00000368389.2_Silent_p.L87L|MUC1_ENST00000368393.3_Silent_p.L87L|MUC1_ENST00000462215.1_5'UTR|MUC1_ENST00000368392.3_Silent_p.L78L|MUC1_ENST00000342482.4_Intron|MUC1_ENST00000338684.5_Intron|MUC1_ENST00000368396.4_Silent_p.L78L|MUC1_ENST00000337604.5_Silent_p.L87L|MUC1_ENST00000438413.1_Intron	NM_001204292.1|NM_001204294.1	NP_001191221.1|NP_001191223.1	P15941	MUC1_HUMAN	mucin 1, cell surface associated	0						apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|skin(2)	10	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGTCTCTCTGCAGCTCTTGGT	0.483000			T	IGH@	B-NHL								20	63					0	0	1	0	0
ALDH3B1	221	broad.mit.edu	37	11	67790064	67790064	+	Splice_Site	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:67790064C>A	ENST00000539229.1	+	10	1061	c.945C>A	c.(943-945)gcC>gcA	p.A315A	ALDH3B1_ENST00000007633.8_Splice_Site_p.A315A|ALDH3B1_ENST00000342456.6_Splice_Site_p.A279A|ALDH3B1_ENST00000434449.1_3'UTR|ALDH3B1_ENST00000316367.6_Intron	NM_001161473.1	NP_001154945.1	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3 family, member B1	317					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase									NADH(DB00157)	TGCCTGCAGCCCCCACGGTGC	0.667000													8	35					0.0381472	0.0386551	1	1	0
HSP90AA1	3320	broad.mit.edu	37	14	102550783	102550783	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:102550783C>G	ENST00000334701.7	-	7	1747	c.1466G>C	c.(1465-1467)aGa>aCa	p.R489T	HSP90AA1_ENST00000441629.2_Missense_Mutation_p.R188T|HSP90AA1_ENST00000216281.8_Missense_Mutation_p.R367T	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	367					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	GATGAAAACTCTGCGTACATA	0.363000													6	53					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33589760	33589760	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:33589760G>A	ENST00000262873.7	+	42	5904	c.5812G>A	c.(5812-5814)Gcc>Acc	p.A1938T		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1896						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GGAGCAGCAGGCCAACACCAA	0.627000													5	48					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248344246	248344246	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:248344246T>C	ENST00000359682.2	+	1	959	c.959T>C	c.(958-960)gTt>gCt	p.V320A		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	320					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AAACTTTATGTTTTGCTGTTT	0.378000													4	178					0	0	1	0	0
C9orf106	414318	broad.mit.edu	37	9	132084516	132084516	+	RNA	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:132084516G>C	ENST00000316786.1	+	0	477							Q8NAJ2	CI106_HUMAN	chromosome 9 open reading frame 106											large_intestine(1)|lung(1)|ovary(1)|skin(1)	4		Ovarian(14;0.00556)|Medulloblastoma(224;0.235)				CCCAGGCTTGGAGCAAGCAGC	0.617000													4	42					0	0	1	0	0
SPOCK2	9806	broad.mit.edu	37	10	73826744	73826744	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:73826744T>C	ENST00000373109.2	-	8	1288	c.844A>G	c.(844-846)Atc>Gtc	p.I282V	SPOCK2_ENST00000536168.1_Missense_Mutation_p.I282V|SPOCK2_ENST00000317376.4_Missense_Mutation_p.I282V|SPOCK2_ENST00000460053.1_5'UTR	NM_001244950.1	NP_001231879.1	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	282					extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						AAGGGACGGATGCAGACCTCG	0.587000													4	64					0	0	1	0	0
CAND1	55832	broad.mit.edu	37	12	67696168	67696168	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:67696168T>C	ENST00000545606.1	+	8	1503	c.1066T>C	c.(1066-1068)Tgc>Cgc	p.C356R		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	356					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		AGCTGCGAAGTGCTTGGATGC	0.413000													19	108					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34192804	34192804	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:34192804C>T	ENST00000297161.2	+	16	2351	c.1977C>T	c.(1975-1977)tgC>tgT	p.C659C	BMPER_ENST00000426693.1_Silent_p.C659C	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	659	TIL.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						ACAAGCCGTGCGTTGCTGGGT	0.522000													24	82					0	0	1	0	0
ANKFY1	51479	broad.mit.edu	37	17	4098278	4098278	+	Missense_Mutation	SNP	G	G	A	rs62064367		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:4098278G>A	ENST00000341657.4	-	10	1402	c.1367C>T	c.(1366-1368)gCg>gTg	p.A456V	ANKFY1_ENST00000574367.1_Missense_Mutation_p.A456V|ANKFY1_ENST00000433651.1_Missense_Mutation_p.A456V|ANKFY1_ENST00000570535.1_Missense_Mutation_p.A498V	NM_016376.3	NP_057460.3	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	456						endosome membrane	metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|liver(1)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						TTTACCTGTCGCCGTGTCAGG	0.557000													4	28					0	0	1	0	0
FAM153A	285596	broad.mit.edu	37	5	177156509	177156509	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:177156509C>T	ENST00000440605.3	-	16	962	c.679G>A	c.(679-681)Gag>Aag	p.E227K	FAM153A_ENST00000393518.3_Intron|FAM153A_ENST00000510276.1_Missense_Mutation_p.E227K|FAM153A_ENST00000513554.1_Intron	NM_173663.3	NP_775934.3	Q9UHL3	F153A_HUMAN	family with sequence similarity 153, member A	227										kidney(6)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|stomach(1)	11	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTGGCTTCCTCAGAGACTGTC	0.453000													38	174					0	0	1	0	0
SLC4A10	57282	broad.mit.edu	37	2	162821630	162821630	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:162821630G>C	ENST00000375514.5	+	23	3336	c.3049G>C	c.(3049-3051)Gat>Cat	p.D1017H	SLC4A10_ENST00000415876.2_Missense_Mutation_p.D1006H|SLC4A10_ENST00000272716.5_Missense_Mutation_p.D1006H|SLC4A10_ENST00000421911.1_Missense_Mutation_p.D1036H|SLC4A10_ENST00000446997.1_Missense_Mutation_p.D1036H	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	1036					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						CAGCTGGTTGGATGATTTGAT	0.358000													9	41					0	0	1	0	0
TTC8	123016	broad.mit.edu	37	14	89307233	89307233	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:89307233C>A	ENST00000338104.6	+	3	312	c.260C>A	c.(259-261)cCt>cAt	p.P87H	TTC8_ENST00000354441.6_Intron|TTC8_ENST00000346301.4_Missense_Mutation_p.P87H|TTC8_ENST00000345383.5_Missense_Mutation_p.P87H|TTC8_ENST00000536576.1_5'UTR|TTC8_ENST00000380656.2_Missense_Mutation_p.P97H			Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8	97					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						TTGAAACTCCCTGGAACTAAT	0.388000													5	46					0.00198382	0.00206209	1	1	0
TTN	7273	broad.mit.edu	37	2	179403819	179403819	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:179403819T>C	ENST00000589042.1	-	353	99067	c.98843A>G	c.(98842-98844)aAc>aGc	p.N32948S	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.N24008S|TTN_ENST00000460472.2_Missense_Mutation_p.N23883S|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.N24075S|TTN_ENST00000591111.1_Missense_Mutation_p.N31307S|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.N30380S|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31307							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAGTCTTGTTGTGTCTGAC	0.507000													12	68					0	0	1	0	0
ZNF25	219749	broad.mit.edu	37	10	38242099	38242099	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:38242099C>G	ENST00000302609.7	-	6	539	c.327G>C	c.(325-327)caG>caC	p.Q109H	ZNF25_ENST00000374633.1_5'UTR	NM_145011.2	NP_659448.1	P17030	ZNF25_HUMAN	zinc finger protein 25	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				TATGAGTTTTCTGATGTTTTG	0.428000													11	54					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39795196	39795196	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:39795196G>A	ENST00000373272.2	+	18	2486	c.2081G>A	c.(2080-2082)cGg>cAg	p.R694Q	PLCG1_ENST00000373271.1_Missense_Mutation_p.R694Q|PLCG1_ENST00000244007.3_Missense_Mutation_p.R694Q	NM_002660.2	NP_002651.2	P19174	PLCG1_HUMAN	phospholipase C, gamma 1	694	SH2 2.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(16)|skin(6)|urinary_tract(2)	46		Myeloproliferative disorder(115;0.00878)				TTCCTGGTGCGGAAGCGGAAT	0.607000													8	26					0	0	1	0	0
NRIP1	8204	broad.mit.edu	37	21	16338311	16338311	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr21:16338311C>T	ENST00000400202.1	-	3	2915	c.2203G>A	c.(2203-2205)Gat>Aat	p.D735N	NRIP1_ENST00000400199.1_Missense_Mutation_p.D735N|NRIP1_ENST00000318948.4_Missense_Mutation_p.D735N			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	735	Repression domain 3.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		GTACTTTCATCTCTTAAGGGA	0.393000													17	69					0	0	1	0	0
PDE10A	10846	broad.mit.edu	37	6	165806233	165806233	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:165806233G>A	ENST00000366882.1	-	17	1682	c.1528C>T	c.(1528-1530)Cgg>Tgg	p.R510W	PDE10A_ENST00000539869.2_Missense_Mutation_p.R520W|PDE10A_ENST00000354448.4_Missense_Mutation_p.R510W			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	510					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GGAACCCGCCGATAGTTCTTC	0.418000													12	47					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32712275	32712275	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:32712275C>A	ENST00000265074.8	+	1	736	c.393C>A	c.(391-393)atC>atA	p.I131I	NPR3_ENST00000415167.2_Silent_p.I131I|NPR3_ENST00000415685.2_Intron|NPR3_ENST00000434067.2_Intron	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	131					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	CAGACCTTATCCTGGGGCCAG	0.682000													16	76					6.31663e-08	7.18752e-08	1	1	0
GSPT2	23708	broad.mit.edu	37	X	51486903	51486903	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:51486903C>T	ENST00000340438.4	+	1	423	c.181C>T	c.(181-183)Cct>Tct	p.P61S		NM_018094.4	NP_060564.2	Q8IYD1	ERF3B_HUMAN	G1 to S phase transition 2	61					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Ovarian(276;0.236)					GCCCTTCGTGCCTAACGTACA	0.687000													5	12					0	0	1	0	0
TARBP1	6894	broad.mit.edu	37	1	234565225	234565225	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:234565225G>A	ENST00000040877.1	-	16	2807	c.2808C>T	c.(2806-2808)ctC>ctT	p.L936L		NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	936					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			AAAGAACTGTGAGGGCTTCTA	0.423000													16	91					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7230630	7230630	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:7230630T>C	ENST00000379938.2	+	10	2835	c.2298T>C	c.(2296-2298)cgT>cgC	p.R766R	RREB1_ENST00000349384.6_Silent_p.R766R|RREB1_ENST00000379933.3_Silent_p.R766R|RREB1_ENST00000334984.6_Silent_p.R766R	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	766					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				AGCACTATCGTGCCCTGCGCA	0.697000													9	13					0	0	1	0	0
CPNE1	8904	broad.mit.edu	37	20	34219208	34219208	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:34219208G>A	ENST00000317619.3	-	11	1177	c.783C>T	c.(781-783)atC>atT	p.I261I	CPNE1_ENST00000397446.1_Silent_p.I261I|CPNE1_ENST00000352393.4_Silent_p.I261I|CPNE1_ENST00000317677.5_Silent_p.I266I|CPNE1_ENST00000397443.1_Silent_p.I261I|CPNE1_ENST00000397445.1_Silent_p.I261I|CPNE1_ENST00000397442.1_Silent_p.I261I			Q99829	CPNE1_HUMAN	copine I	261					lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			breast(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			TCTTGACACGGATAGTTCCAG	0.478000													13	90					0	0	1	0	0
RBP5	83758	broad.mit.edu	37	12	7280888	7280888	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:7280888A>G	ENST00000266560.3	-	2	366	c.200T>C	c.(199-201)gTg>gCg	p.V67A	RBP5_ENST00000542370.1_Missense_Mutation_p.V67A	NM_031491.2	NP_113679.1	P82980	RET5_HUMAN	retinol binding protein 5, cellular	67						cytoplasm	retinal binding|retinol binding|transporter activity			autonomic_ganglia(1)|endometrium(4)|large_intestine(1)|lung(3)|ovary(1)	10					Vitamin A(DB00162)	CTCCACTCCCACATCAAACTG	0.592000													8	25					0	0	1	0	0
CSF2RA	1438	broad.mit.edu	37	X	1401600	1401600	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:1401600C>T	ENST00000381524.3	+	3	190	c.4C>T	c.(4-6)Ctt>Ttt	p.L2F	CSF2RA_ENST00000432318.2_Missense_Mutation_p.L2F|CSF2RA_ENST00000361536.3_Missense_Mutation_p.L2F|CSF2RA_ENST00000355432.3_Missense_Mutation_p.L2F|CSF2RA_ENST00000381529.3_Missense_Mutation_p.L2F|CSF2RA_ENST00000381500.1_Missense_Mutation_p.L2F|CSF2RA_ENST00000417535.2_Missense_Mutation_p.L2F|CSF2RA_ENST00000501036.2_5'UTR|CSF2RA_ENST00000381509.3_Missense_Mutation_p.L2F|CSF2RA_ENST00000355805.2_Missense_Mutation_p.L2F|CSF2RA_ENST00000494969.2_Missense_Mutation_p.L2F			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	2						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	CAGCACCATGCTTCTCCTGGT	0.537000													15	179					0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38395978	38395978	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:38395978G>A	ENST00000377698.3	+	2	386	c.233G>A	c.(232-234)cGg>cAg	p.R78Q		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	78					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	GATGTGGATCGGGCCGTGAAA	0.657000													12	52					0	0	1	0	0
ASIC5	51802	broad.mit.edu	37	4	156763401	156763401	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:156763401G>A	ENST00000537611.2	-	6	1013	c.967C>T	c.(967-969)Cac>Tac	p.H323Y		NM_017419.2	NP_059115.1	Q9NY37	ACCN5_HUMAN	acid-sensing (proton-gated) ion channel family member 5	323						integral to membrane|plasma membrane											TTTTTTATGTGCTGGGCTTTG	0.418000													6	115					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40900287	40900287	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:40900287C>T	ENST00000324001.7	-	7	4242	c.3972G>A	c.(3970-3972)gaG>gaA	p.E1324E	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	1324					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCTTGGCCTTCTCACCCTCCT	0.677000													3	11					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95683790	95683790	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:95683790G>A	ENST00000433389.2	+	11	1533	c.1343G>A	c.(1342-1344)cGc>cAc	p.R448H	ESRP1_ENST00000454170.2_Missense_Mutation_p.R448H|ESRP1_ENST00000358397.5_Missense_Mutation_p.R448H|ESRP1_ENST00000423620.2_Missense_Mutation_p.R448H	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	448	RRM 3.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding	p.R448L(2)	ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						GACTGTATACGCCTTCGAGGT	0.502000													7	57					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	182910829	182910829	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:182910829T>C	ENST00000328913.3	-	27	3271	c.2974A>G	c.(2974-2976)Act>Gct	p.T992A	MCF2L2_ENST00000468976.1_5'UTR|MCF2L2_ENST00000473233.1_Missense_Mutation_p.T992A	NM_015078.2	NP_055893	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	992					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TCCTTGCTAGTGGTAGCTCTT	0.502000													5	109					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20649500	20649500	+	RNA	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:20649500G>T	ENST00000428453.1	-	0	2698																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CTCTGTGTCCGAATCCTCTGC	0.577000													14	122					3.99206e-14	4.69856e-14	1	1	0
FAT4	79633	broad.mit.edu	37	4	126371549	126371549	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:126371549C>A	ENST00000394329.3	+	9	9391	c.9378C>A	c.(9376-9378)taC>taA	p.Y3126*	FAT4_ENST00000335110.5_Nonsense_Mutation_p.Y1424*	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3126	Cadherin 30.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGATTAAGTACAGCATTTCTT	0.408000													12	58					0.00185496	0.00193107	1	1	0
TEX15	56154	broad.mit.edu	37	8	30702515	30702515	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:30702515G>A	ENST00000256246.2	-	1	4093	c.4019C>T	c.(4018-4020)gCt>gTt	p.A1340V		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1340										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TGTCACTGCAGCGGCTGATAA	0.388000													4	110					0	0	1	0	0
LRRC8B	23507	broad.mit.edu	37	1	90049856	90049856	+	Silent	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:90049856C>G	ENST00000330947.2	+	5	2007	c.1647C>G	c.(1645-1647)ctC>ctG	p.L549L	RP5-1007M22.2_ENST00000443562.1_RNA|LRRC8B_ENST00000439853.1_Silent_p.L549L|LRRC8B_ENST00000358200.4_Silent_p.L549L	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	549						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		AGAGCAGCCTCTCCCGGATCC	0.458000													3	69					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196309547	196309547	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:196309547C>G	ENST00000367433.5	-	16	1808	c.1707G>C	c.(1705-1707)caG>caC	p.Q569H	KCNT2_ENST00000451324.2_Missense_Mutation_p.Q180H|KCNT2_ENST00000367431.4_Missense_Mutation_p.Q519H|KCNT2_ENST00000609185.1_Missense_Mutation_p.Q519H|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000294725.9_Missense_Mutation_p.Q569H	NM_198503.2	NP_940905.2	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	569						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity	p.Q569Q(1)		NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TGCTTTTTCTCTGCTGGTCTT	0.343000													4	83					0	0	1	0	0
SMPD1	6609	broad.mit.edu	37	11	6415175	6415175	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:6415175G>A	ENST00000342245.4	+	5	1558	c.1390G>A	c.(1390-1392)Gaa>Aaa	p.E464K	SMPD1_ENST00000356761.2_Missense_Mutation_p.E408K|SMPD1_ENST00000527275.1_Missense_Mutation_p.E463K|SMPD1_ENST00000299397.3_Missense_Mutation_p.E420K	NM_000543.4|NM_001007593.2	NP_000534.3|NP_001007594.2	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid lysosomal	462					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(3)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	TCATGTGGATGAATTTGAGGT	0.517000													10	61					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169938339	169938339	+	Translation_Start_Site	SNP	A	A	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:169938339A>T	ENST00000421653.1	+	0	332				DHRS9_ENST00000412271.1_Missense_Mutation_p.D83V|DHRS9_ENST00000357546.2_Missense_Mutation_p.D83V|DHRS9_ENST00000436483.2_Missense_Mutation_p.D83V|DHRS9_ENST00000327239.4_Missense_Mutation_p.D83V|DHRS9_ENST00000432060.2_Missense_Mutation_p.D143V|DHRS9_ENST00000428522.1_Missense_Mutation_p.D83V|DHRS9_ENST00000602501.1_Missense_Mutation_p.D83V			Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9						9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						GTGCTTCTGGATGTGACCGAC	0.493000													8	37					0	0	1	0	0
MCM4	4173	broad.mit.edu	37	8	48875394	48875394	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:48875394C>A	ENST00000262105.2	+	5	781	c.572C>A	c.(571-573)cCt>cAt	p.P191H	MCM4_ENST00000523944.1_Missense_Mutation_p.P191H	NM_005914.3	NP_005905.2	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	191					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(7)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	44		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				ATTACTGAACCTCTATACATG	0.318000													22	111					2.89027e-11	3.35565e-11	1	1	0
EIF3L	51386	broad.mit.edu	37	22	38273924	38273924	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:38273924C>A	ENST00000412331.2	+	11	1903	c.1321C>A	c.(1321-1323)Ctg>Atg	p.L441M	EIF3L_ENST00000406934.1_Missense_Mutation_p.L343M|EIF3L_ENST00000381683.6_Missense_Mutation_p.L393M	NM_016091.3	NP_057175.1	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3, subunit L	441						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			kidney(2)|large_intestine(3)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						AGAGCCCTTCCTGCAGCAGCT	0.512000													3	57					0.004672	0.00482703	1	1	0
MGA	23269	broad.mit.edu	37	15	41988424	41988424	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:41988424G>A	ENST00000219905.7	+	3	1397	c.1216G>A	c.(1216-1218)Gag>Aag	p.E406K	MGA_ENST00000570161.1_Missense_Mutation_p.E406K|MGA_ENST00000568630.1_3'UTR|MGA_ENST00000545763.1_Missense_Mutation_p.E406K|MGA_ENST00000389936.4_Missense_Mutation_p.E406K|MGA_ENST00000566586.1_Missense_Mutation_p.E406K	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	406						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GAAACAGGAAGAGACAGATGA	0.423000													5	47					0	0	1	0	0
WDR81	124997	broad.mit.edu	37	17	1636047	1636047	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:1636047G>A	ENST00000409644.1	+	6	4411	c.4411G>A	c.(4411-4413)Gcc>Acc	p.A1471T	WDR81_ENST00000437219.2_Missense_Mutation_p.A268T|WDR81_ENST00000419248.1_Missense_Mutation_p.A244T|WDR81_ENST00000545662.1_Missense_Mutation_p.A102T|RP11-961A15.1_ENST00000576540.1_RNA|WDR81_ENST00000446363.1_Missense_Mutation_p.A110T|WDR81_ENST00000309182.5_Missense_Mutation_p.A420T	NM_001163809.1	NP_001157281.1	B3KXU1	B3KXU1_HUMAN	WD repeat domain 81	244										cervix(1)|endometrium(1)|kidney(3)|lung(6)|ovary(2)|prostate(2)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CGTGGACCCCGCCCTGCTGGA	0.627000													9	25					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25150118	25150118	+	Silent	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:25150118G>C	ENST00000332271.5	-	8	1256	c.840C>G	c.(838-840)ctC>ctG	p.L280L	PIWIL3_ENST00000533313.1_Silent_p.L171L|PIWIL3_ENST00000527701.1_Silent_p.L171L|PIWIL3_ENST00000532537.2_5'UTR	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	280					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						CATCGGCACAGAGGGTAATGC	0.423000													12	51					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10541667	10541667	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:10541667G>A	ENST00000583535.1	-	27	3509	c.3422C>T	c.(3421-3423)gCc>gTc	p.A1141V	MYH3_ENST00000226209.7_Missense_Mutation_p.A1141V	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1141					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CAGCTCCCGGGCATAGTCGCT	0.637000													3	40					0	0	1	0	0
LCP2	3937	broad.mit.edu	37	5	169689861	169689861	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:169689861G>C	ENST00000046794.5	-	12	1418	c.803C>G	c.(802-804)tCg>tGg	p.S268W	LCP2_ENST00000521416.1_Missense_Mutation_p.S63W	NM_005565.3	NP_005556.1	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	268					immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	23	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		CGCTGGAATCGAGGGCTGCAA	0.423000													6	47					0	0	1	0	0
SLC25A12	8604	broad.mit.edu	37	2	172690501	172690501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:172690501G>A	ENST00000422440.2	-	8	854	c.817C>T	c.(817-819)Cag>Tag	p.Q273*	SLC25A12_ENST00000392592.4_Nonsense_Mutation_p.Q166*	NM_003705.4	NP_003696.2	O75746	CMC1_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 12	273					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|upper_aerodigestive_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	TCTGCAAGCTGATATAGAATA	0.333000													20	97					0	0	1	0	0
LRRC4	64101	broad.mit.edu	37	7	127670496	127670496	+	Silent	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:127670496G>C	ENST00000249363.3	-	2	455	c.198C>G	c.(196-198)ctC>ctG	p.L66L	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	66	LRRNT.					cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		GGACCTCGGAGAGGCCCCGGC	0.647000													9	57					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19181066	19181066	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:19181066C>T	ENST00000375371.3	-	3	919	c.898G>A	c.(898-900)Gcc>Acc	p.A300T	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	300					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GACTCGGAGGCGATCCACACG	0.647000													3	19					0	0	1	0	0
ESR1	2099	broad.mit.edu	37	6	152201851	152201851	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:152201851G>C	ENST00000440973.1	+	5	1075	c.705G>C	c.(703-705)aaG>aaC	p.K235N	ESR1_ENST00000443427.1_Missense_Mutation_p.K235N|ESR1_ENST00000338799.5_Missense_Mutation_p.K235N|ESR1_ENST00000406599.1_Intron|ESR1_ENST00000456483.2_Missense_Mutation_p.K235N|ESR1_ENST00000427531.2_Missense_Mutation_p.K62N|ESR1_ENST00000206249.3_Missense_Mutation_p.K235N	NM_001122742.1	NP_001116214.1	P03372	ESR1_HUMAN	estrogen receptor 1	235	Mediates interaction with DNTTIP2.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(19)|ovary(1)|prostate(2)|skin(1)	49		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	ACAGGAGGAAGAGCTGCCAGG	0.498000													10	53					0	0	1	0	0
ATL1	51062	broad.mit.edu	37	14	51095136	51095136	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:51095136C>T	ENST00000441560.2	+	13	1988	c.1507C>T	c.(1507-1509)Ctg>Ttg	p.L503L	ATL1_ENST00000358385.6_Silent_p.L503L|ATL1_ENST00000354525.4_Silent_p.L503L|ATL1_ENST00000357032.3_Silent_p.L503L	NM_001127713.1	NP_001121185.1	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1	503	Sufficient for membrane association.				axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			central_nervous_system(1)|cervix(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(3)	18						ATACCGAGAGCTGGGAGCTGT	0.458000													13	48					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152420152	152420152	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:152420152G>A	ENST00000397345.3	-	119	18863	c.18661C>T	c.(18661-18663)Cac>Tac	p.H6221Y	NEB_ENST00000604864.1_Missense_Mutation_p.H6221Y|NEB_ENST00000172853.10_Missense_Mutation_p.H4520Y|NEB_ENST00000427231.2_Missense_Mutation_p.H6221Y|NEB_ENST00000603639.1_Missense_Mutation_p.H6221Y|NEB_ENST00000409198.1_Missense_Mutation_p.H4520Y	NM_001164508.1	NP_001157980	P20929	NEBU_HUMAN	nebulin	6203					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCCAGACAGTGAACCACACCA	0.443000													33	172					0	0	1	0	0
NR4A1	3164	broad.mit.edu	37	12	52450304	52450304	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:52450304C>T	ENST00000545748.1	+	5	2190	c.1195C>T	c.(1195-1197)Cgg>Tgg	p.R399W	NR4A1_ENST00000243050.1_Missense_Mutation_p.R345W|NR4A1_ENST00000394825.1_Missense_Mutation_p.R345W|NR4A1_ENST00000360284.3_Missense_Mutation_p.R358W|NR4A1_ENST00000394824.2_Missense_Mutation_p.R345W|NR4A1_ENST00000550082.1_Missense_Mutation_p.R358W			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	345					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CCTGAAGGGGCGGCGGGGCCG	0.627000													14	92					0	0	1	0	0
AMFR	267	broad.mit.edu	37	16	56443414	56443414	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:56443414C>T	ENST00000290649.5	-	3	645	c.435G>A	c.(433-435)gtG>gtA	p.V145V	RP11-413H22.2_ENST00000563090.1_RNA	NM_001144.5	NP_001135.3	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor, E3 ubiquitin protein ligase	145					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17						ACCACATGACCACCTCTTCCA	0.393000													13	71					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124457563	124457563	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:124457563C>G	ENST00000329446.4	-	3	725	c.694G>C	c.(694-696)Gag>Cag	p.E232Q		NM_001010912.1	NP_001010912.1	Q5SQS8	CJ120_HUMAN	chromosome 10 open reading frame 120	232										endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|skin(2)|stomach(1)|urinary_tract(1)	21		all_neural(114;0.169)|Glioma(114;0.222)				TTTTTTCCCTCTGCCTCCTCT	0.378000													16	29					0	0	1	0	0
RS1	6247	broad.mit.edu	37	X	18675762	18675762	+	Missense_Mutation	SNP	C	C	T	rs62645883	byFrequency	TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:18675762C>T	ENST00000379984.3	-	2	116	c.76G>A	c.(76-78)Gag>Aag	p.E26K		NM_000330.3	NP_000321.1	O15537	XLRS1_HUMAN	retinoschisin 1	26					cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				cervix(1)|endometrium(4)|large_intestine(5)|lung(2)|ovary(2)|skin(1)	15	Hepatocellular(33;0.183)					TTACATACCTCGGTAGACGAT	0.333000													12	39					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71886083	71886083	+	Missense_Mutation	SNP	G	G	A	rs143163327		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:71886083G>A	ENST00000258104.3	+	43	4991	c.4714G>A	c.(4714-4716)Gcc>Acc	p.A1572T	DYSF_ENST00000409366.1_Missense_Mutation_p.A1594T|DYSF_ENST00000409744.1_Missense_Mutation_p.A1580T|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000429174.2_Missense_Mutation_p.A1593T|DYSF_ENST00000394120.2_Missense_Mutation_p.A1573T|DYSF_ENST00000410020.3_Missense_Mutation_p.A1611T|DYSF_ENST00000413539.2_Missense_Mutation_p.A1603T|DYSF_ENST00000409651.1_Missense_Mutation_p.A1604T|DYSF_ENST00000410041.1_Missense_Mutation_p.A1590T|DYSF_ENST00000409582.3_Missense_Mutation_p.A1610T|DYSF_ENST00000409762.1_Missense_Mutation_p.A1589T	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1572	C2 5.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding	p.A1572T(1)		autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CCAGCTGGCCGCCCAGGGACC	0.547000													15	70					0	0	1	0	0
IP6K3	117283	broad.mit.edu	37	6	33694614	33694614	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:33694614G>T	ENST00000451316.1	-	5	1018	c.483C>A	c.(481-483)acC>acA	p.T161T	IP6K3_ENST00000293756.4_Silent_p.T161T	NM_001142883.1	NP_001136355.1	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	161					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity			skin(1)	1						GGTTTCCGTTGGTGTCTTCCA	0.632000													11	88					0.0135373	0.0139026	1	1	0
ACAD8	27034	broad.mit.edu	37	11	134131681	134131681	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:134131681G>A	ENST00000281182.4	+	9	1095	c.989G>A	c.(988-990)cGg>cAg	p.R330Q	ACAD8_ENST00000537423.1_Missense_Mutation_p.R253Q|ACAD8_ENST00000524547.1_3'UTR|ACAD8_ENST00000374752.4_Missense_Mutation_p.R203Q|ACAD8_ENST00000543332.1_3'UTR	NM_014384.2	NP_055199.1	Q9UKU7	ACAD8_HUMAN	acyl-CoA dehydrogenase family, member 8	330					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		GTGGCCGCGCGGCTGATGGTC	0.562000													4	32					0	0	1	0	0
TTLL11	158135	broad.mit.edu	37	9	124751555	124751555	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:124751555C>T	ENST00000321582.5	-	4	1645	c.1458G>A	c.(1456-1458)acG>acA	p.T486T	TTLL11_ENST00000474723.1_5'UTR|TTLL11_ENST00000373776.3_Silent_p.T486T	NM_001139442.1	NP_001132914.1	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	486	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(3)|skin(1)	18						GCGCGATGACCGTCTTAATCA	0.537000													13	59					0	0	1	0	0
SERINC3	10955	broad.mit.edu	37	20	43139973	43139973	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:43139973G>A	ENST00000342374.4	-	4	589	c.432C>T	c.(430-432)atC>atT	p.I144I	SERINC3_ENST00000255175.1_Silent_p.I144I|SERINC3_ENST00000541235.1_Silent_p.I89I	NM_006811.2	NP_006802.1	Q13530	SERC3_HUMAN	serine incorporator 3	144						integral to membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(2)|lung(8)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			AGCCAACCATGATTCCAATAA	0.348000													8	42					0	0	1	0	0
HSD11B1L	374875	broad.mit.edu	37	19	5687833	5687833	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:5687833G>A	ENST00000581521.1	+	10	1213	c.738G>A	c.(736-738)acG>acA	p.T246T	RPL36_ENST00000582380.2_Intron|HSD11B1L_ENST00000581773.1_Silent_p.T246T|HSD11B1L_ENST00000339423.2_Silent_p.T246T|HSD11B1L_ENST00000577917.1_Intron|HSD11B1L_ENST00000583928.1_Silent_p.T112T|HSD11B1L_ENST00000423665.2_Intron|HSD11B1L_ENST00000301382.4_Silent_p.T165T|HSD11B1L_ENST00000581893.1_Silent_p.T112T|RPL36_ENST00000579649.1_Intron|RPL36_ENST00000577222.1_Intron|HSD11B1L_ENST00000411793.2_Intron|HSD11B1L_ENST00000342970.2_Silent_p.T159T			Q7Z5J1	DHI1L_HUMAN	hydroxysteroid (11-beta) dehydrogenase 1-like	0						extracellular region	binding|oxidoreductase activity										gcggcgccacgcgcgcggccg	0.746000													3	8					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111697648	111697648	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:111697648G>C	ENST00000435970.1	-	15	2492	c.1676C>G	c.(1675-1677)tCa>tGa	p.S559*	REV3L_ENST00000368802.3_Nonsense_Mutation_p.S637*|REV3L_ENST00000368805.1_Nonsense_Mutation_p.S637*|REV3L_ENST00000358835.3_Nonsense_Mutation_p.S637*			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	637					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AGAATTTTCTGAATGAACAGT	0.318000								DNA polymerases (catalytic subunits)					12	55					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90136680	90136680	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:90136680G>A	ENST00000405460.2	+	78	16993	c.16897G>A	c.(16897-16899)Gat>Aat	p.D5633N	GPR98_ENST00000425867.2_Missense_Mutation_p.D1294N	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5633					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGGGCTTGCAGATCAGCTACA	0.463000													8	50					0	0	1	0	0
MATN2	4147	broad.mit.edu	37	8	99045363	99045363	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:99045363T>C	ENST00000254898.5	+	17	2906	c.2675T>C	c.(2674-2676)tTa>tCa	p.L892S	MATN2_ENST00000521689.1_Missense_Mutation_p.L873S|MATN2_ENST00000522025.2_Missense_Mutation_p.L608S|MATN2_ENST00000520016.1_Missense_Mutation_p.L892S|MATN2_ENST00000524308.1_Missense_Mutation_p.L851S|RPL30_ENST00000518164.1_Intron	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	892						proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			GACAATCTTTTACGGTCTACA	0.363000													6	11					0	0	1	0	0
TRIM4	89122	broad.mit.edu	37	7	99490167	99490167	+	Silent	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:99490167A>G	ENST00000355947.2	-	7	1251	c.1122T>C	c.(1120-1122)gtT>gtC	p.V374V	TRIM4_ENST00000349062.2_Silent_p.V348V	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	374	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				CTGAGGTGAAAACGTTTTTTC	0.458000													24	83					0	0	1	0	0
MARK3	4140	broad.mit.edu	37	14	103931903	103931903	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:103931903C>G	ENST00000429436.2	+	8	1060	c.550C>G	c.(550-552)Cta>Gta	p.L184V	MARK3_ENST00000553942.1_Missense_Mutation_p.L184V|MARK3_ENST00000416682.2_Missense_Mutation_p.L207V|MARK3_ENST00000216288.7_Missense_Mutation_p.L184V|MARK3_ENST00000303622.9_Missense_Mutation_p.L184V|MARK3_ENST00000440884.3_Intron|MARK3_ENST00000335102.5_Missense_Mutation_p.L207V|MARK3_ENST00000561071.1_Intron	NM_001128918.1|NM_001128919.1	NP_001122390.1|NP_001122391.1	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	184	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30		Melanoma(154;0.155)	Epithelial(46;0.241)			GGCTGAAAATCTATTGTTAGA	0.348000													11	73					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	712749	712749	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:712749C>T	ENST00000382303.1	+	7	2635	c.1983C>T	c.(1981-1983)gcC>gcT	p.A661A	KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382293.3_Silent_p.A503A|KANK1_ENST00000382297.2_Silent_p.A661A	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	661					negative regulation of actin filament polymerization	cytoplasm		p.A503A(1)|p.A661A(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TGGAAGCTGCCGTCATGGCAG	0.577000													3	14					0	0	1	0	0
NPHP1	4867	broad.mit.edu	37	2	110922195	110922195	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:110922195C>G	ENST00000316534.4	-	8	914	c.841G>C	c.(841-843)Gag>Cag	p.E281Q	NPHP1_ENST00000393272.3_Missense_Mutation_p.E281Q|NPHP1_ENST00000355301.4_Intron|NPHP1_ENST00000417665.1_Intron|NPHP1_ENST00000445609.2_Intron			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	281					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						TCCACAGTCTCCATCCTATTT	0.458000													48	165					0	0	1	0	0
ZNF217	7764	broad.mit.edu	37	20	52198759	52198759	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:52198759C>T	ENST00000371471.2	-	2	1032	c.607G>A	c.(607-609)Gtc>Atc	p.V203I	ZNF217_ENST00000302342.3_Missense_Mutation_p.V203I			O75362	ZN217_HUMAN	zinc finger protein 217	203					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			TGCACCTGGACGACCTCGTTG	0.483000													10	151					0	0	1	0	0
RHBDL3	162494	broad.mit.edu	37	17	30648058	30648058	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:30648058C>T	ENST00000269051.4	+	9	1039	c.1025C>T	c.(1024-1026)gCg>gTg	p.A342V	RHBDL3_ENST00000538145.1_Missense_Mutation_p.A334V|RHBDL3_ENST00000536287.1_Missense_Mutation_p.A244V	NM_138328.2	NP_612201.1	P58872	RHBL3_HUMAN	rhomboid, veinlet-like 3 (Drosophila)	342					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)|skin(1)	16		Breast(31;0.116)|Ovarian(249;0.182)				AGCTTTGTGGCGCACTTGGGT	0.642000													9	50					0	0	1	0	0
HMMR	3161	broad.mit.edu	37	5	162909657	162909657	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:162909657G>A	ENST00000393915.4	+	13	1538	c.1395G>A	c.(1393-1395)gcG>gcA	p.A465A	HMMR_ENST00000432118.2_Silent_p.A378A|HMMR_ENST00000358715.3_Silent_p.A464A|HMMR_ENST00000353866.3_Silent_p.A449A	NM_001142556.1|NM_012484.2	NP_001136028.1|NP_036616.2	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor (RHAMM)	464						cell surface|cytoplasm	hyaluronic acid binding			cervix(1)|kidney(3)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	23	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		GCTATAAAGCGTTAACAGCCA	0.348000													7	59					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79971671	79971671	+	Silent	SNP	A	A	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:79971671A>C	ENST00000373275.4	-	20	2526	c.2310T>G	c.(2308-2310)tcT>tcG	p.S770S	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	770										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						GAGTAGTGTAAGATGGCTTTT	0.353000													23	35					0	0	1	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161167820	161167820	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:161167820G>A	ENST00000367996.5	-	1	1026	c.598C>T	c.(598-600)Ctt>Ttt	p.L200F	ADAMTS4_ENST00000367995.3_Missense_Mutation_p.L200F	NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4						proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GGGCTTCCAAGAGGAGCCTTG	0.627000													3	46					0	0	1	0	0
CAMK1G	57172	broad.mit.edu	37	1	209783233	209783233	+	Silent	SNP	G	G	C	rs56379151	byFrequency	TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:209783233G>C	ENST00000009105.1	+	9	1031	c.786G>C	c.(784-786)ccG>ccC	p.P262P	CAMK1G_ENST00000361322.2_Silent_p.P262P|CAMK1G_ENST00000494990.1_3'UTR			Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	262	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|large_intestine(8)|lung(8)|stomach(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		AGAAGGATCCGAACGAGCGGT	0.498000													9	53					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140552932	140552932	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:140552932C>T	ENST00000231137.3	+	1	690	c.516C>T	c.(514-516)atC>atT	p.I172I		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		172	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTACACCATCAGCCCCAATG	0.468000													3	41					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45817735	45817735	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr21:45817735G>C	ENST00000397928.1	+	13	2483	c.2038G>C	c.(2038-2040)Gag>Cag	p.E680Q	TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000397932.2_Missense_Mutation_p.E680Q|TRPM2_ENST00000300482.5_Missense_Mutation_p.E680Q|TRPM2_ENST00000300481.9_Missense_Mutation_p.E660Q	NM_003307.3	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	680						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GGCGCTGGCGGAGGAGTATGA	0.647000													7	15					0	0	1	0	0
KBTBD12	166348	broad.mit.edu	37	3	127703061	127703061	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:127703061G>A	ENST00000405109.1	+	6	2279	c.1812G>A	c.(1810-1812)atG>atA	p.M604I	KBTBD12_ENST00000492025.1_3'UTR|KBTBD12_ENST00000343941.4_Missense_Mutation_p.M179I|KBTBD12_ENST00000405256.1_Missense_Mutation_p.M604I|KBTBD12_ENST00000407609.3_Missense_Mutation_p.M211I			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	604										endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						TAGCCAGGATGAATCCCCGAG	0.502000													37	76					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83838630	83838630	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:83838630C>A	ENST00000349129.2	+	16	2004	c.1744C>A	c.(1744-1746)Cct>Act	p.P582T	DOPEY1_ENST00000237163.5_Missense_Mutation_p.P563T|DOPEY1_ENST00000369739.3_Missense_Mutation_p.P573T	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	582					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TCATGAAAATCCTACTGAAGT	0.358000													7	55					0.000157383	0.000167925	1	1	0
PTPRN2	5799	broad.mit.edu	37	7	157370773	157370773	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:157370773G>A	ENST00000389413.3	-	17	2572	c.2469C>T	c.(2467-2469)ggC>ggT	p.G823G	PTPRN2_ENST00000404321.2_Silent_p.G875G|PTPRN2_ENST00000389418.4_Silent_p.G852G|PTPRN2_ENST00000409483.1_Silent_p.G814G|PTPRN2_ENST00000389416.4_Silent_p.G835G	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	852	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		ACTGCCGGACGCCGTTCTCCG	0.632000													12	27					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30361941	30361941	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:30361941C>T	ENST00000327564.7	+	6	2131	c.2070C>T	c.(2068-2070)cgC>cgT	p.R690R	LRRC37B_ENST00000584368.1_Silent_p.R624R|LRRC37B_ENST00000394713.3_Silent_p.R612R|LRRC37B_ENST00000341671.7_Silent_p.R663R|LRRC37B_ENST00000543378.2_Silent_p.R581R			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	663						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TTCTCAATCGCAATCCTCTGA	0.323000													5	67					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74639139	74639139	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:74639139G>A	ENST00000253159.8	+	23	4365		c.e23+1		ZNF236_ENST00000320610.9_Splice_Site	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236						cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TACGTTGCAGGTATGACACCT	0.433000													14	77					0	0	1	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40843425	40843425	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:40843425C>T	ENST00000264638.4	+	15	2457	c.2240C>T	c.(2239-2241)aCc>aTc	p.T747I	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	747	Fibrinogen C-terminal.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GGACTGCTGACCTTTGTGGAC	0.592000													9	43					0	0	1	0	0
AGAP10	728127	broad.mit.edu	37	10	47207813	47207813	+	Splice_Site	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:47207813T>C	ENST00000355232.3	-	5	3482	c.470A>G	c.(469-471)cAt>cGt	p.H157R	AGAP10_ENST00000413193.2_Splice_Site_p.H228R|RP11-144G6.12_ENST00000605970.1_RNA|AGAP10_ENST00000452145.2_Splice_Site_p.H132R					ArfGAP with GTPase domain, ankyrin repeat and PH domain 10									p.H228R(20)		endometrium(5)|kidney(3)|lung(1)|prostate(2)|urinary_tract(1)	12						TTTACTTACATGGTTTGTACA	0.294000													5	60					0	0	1	0	0
ZNF280D	54816	broad.mit.edu	37	15	56924104	56924104	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:56924104G>A	ENST00000559237.1	-	21	3176	c.2493C>T	c.(2491-2493)caC>caT	p.H831H	ZNF280D_ENST00000267807.7_Silent_p.H844H	NM_001002843.1	NP_001002843.1	Q6N043	Z280D_HUMAN	zinc finger protein 280D	844					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(4)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	30				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		CCTGACAAACGTGTTGTATTT	0.363000													23	103					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52889675	52889675	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:52889675C>T	ENST00000371544.3	-	30	5130		c.e30-1		ZCCHC11_ENST00000257177.4_Splice_Site	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11						miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						GCACATCTGTCTGTTGGATAC	0.448000													4	16					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138764842	138764842	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:138764842C>A	ENST00000242351.5	-	4	1161	c.845G>T	c.(844-846)aGg>aTg	p.R282M	ZC3HAV1_ENST00000464606.1_Missense_Mutation_p.R282M|ZC3HAV1_ENST00000471652.1_Missense_Mutation_p.R282M	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	282					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						CAGGGAAGCCCTGTGGCTGAT	0.587000													28	94					9.39395e-14	1.10375e-13	1	1	0
TAAR9	134860	broad.mit.edu	37	6	132859631	132859631	+	RNA	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:132859631A>G	ENST00000434551.1	+	0	203					NM_175057.3	NP_778227.3	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9 (gene/pseudogene)							plasma membrane	G-protein coupled receptor activity					Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		ACACCTACAAACTTTCTGATT	0.517000													10	69					0	0	1	0	0
FAM171B	165215	broad.mit.edu	37	2	187626804	187626804	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:187626804C>A	ENST00000304698.5	+	8	1938	c.1735C>A	c.(1735-1737)Cga>Aga	p.R579R		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	579						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						ACCAGTAAATCGAGAGAACTT	0.453000													6	29					0.0293803	0.0298156	1	1	0
DOCK1	1793	broad.mit.edu	37	10	128817063	128817063	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:128817063G>A	ENST00000280333.6	+	13	1337	c.1228G>A	c.(1228-1230)Gct>Act	p.A410T	RP11-223P11.2_ENST00000420941.2_RNA|RP11-223P11.3_ENST00000594614.1_RNA|RP11-223P11.3_ENST00000595456.1_RNA|RP11-223P11.3_ENST00000599979.1_RNA|RP11-223P11.3_ENST00000594559.1_RNA|RP11-223P11.3_ENST00000601826.1_RNA|RP11-223P11.3_ENST00000601242.1_RNA	NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	410					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CACAGCTGTGGCTCGAAAAAC	0.493000													5	19					0	0	1	0	0
GPRIN1	114787	broad.mit.edu	37	5	176026205	176026205	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:176026205G>C	ENST00000303991.4	-	2	808	c.631C>G	c.(631-633)Ctt>Gtt	p.L211V		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	211						growth cone|plasma membrane				NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGGATCCAAGATCTTCCTTT	0.498000													17	74					0	0	1	0	0
STAT5A	6776	broad.mit.edu	37	17	40460320	40460320	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:40460320G>A	ENST00000345506.4	+	17	2673	c.2031G>A	c.(2029-2031)gaG>gaA	p.E677E	STAT5A_ENST00000587646.1_Silent_p.E165E|STAT5A_ENST00000452307.2_Silent_p.E674E|STAT5A_ENST00000588868.1_Silent_p.E646E|STAT5A_ENST00000546010.2_Silent_p.E647E|STAT5A_ENST00000590949.1_Silent_p.E677E	NM_003152.3	NP_003143.2	P42229	STA5A_HUMAN	signal transducer and activator of transcription 5A	677	SH2.				2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		CCAAGGATGAGGTCTTCTCCA	0.597000													6	57					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12946095	12946095	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:12946095T>C	ENST00000276297.4	-	16	4602	c.4193A>G	c.(4192-4194)gAt>gGt	p.D1398G	DLC1_ENST00000510318.1_5'UTR|DLC1_ENST00000358919.2_Missense_Mutation_p.D961G|DLC1_ENST00000512044.2_Missense_Mutation_p.D995G|DLC1_ENST00000520226.1_Missense_Mutation_p.D887G	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	1398	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CACTTTTGAATCCAACAGGTC	0.453000													25	74					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8115837	8115837	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:8115837G>A	ENST00000379328.3	+	6	1754	c.1186G>A	c.(1186-1188)Gcc>Acc	p.A396T	GATA3_ENST00000461472.1_3'UTR|GATA3_ENST00000346208.3_Missense_Mutation_p.A395T	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	395					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						TAACCCGGCCGCCCTCTCCAG	0.562000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						18	46					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181721334	181721334	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:181721334C>G	ENST00000526775.1	+	26	3895	c.3730C>G	c.(3730-3732)Cta>Gta	p.L1244V	CACNA1E_ENST00000357570.5_Missense_Mutation_p.L1214V|CACNA1E_ENST00000358338.5_Missense_Mutation_p.L1195V|CACNA1E_ENST00000367567.4_Missense_Mutation_p.L870V|CACNA1E_ENST00000360108.3_Missense_Mutation_p.L1244V|CACNA1E_ENST00000367570.1_Missense_Mutation_p.L1263V|CACNA1E_ENST00000367573.2_Missense_Mutation_p.L1263V	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1263					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GCTCCGAGTTCTAAGGCCACT	0.517000													19	37					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152553691	152553691	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:152553691C>T	ENST00000397345.3	-	16	1643	c.1441G>A	c.(1441-1443)Gca>Aca	p.A481T	NEB_ENST00000604864.1_Missense_Mutation_p.A481T|NEB_ENST00000172853.10_Missense_Mutation_p.A481T|NEB_ENST00000427231.2_Missense_Mutation_p.A481T|NEB_ENST00000603639.1_Missense_Mutation_p.A481T|NEB_ENST00000409198.1_Missense_Mutation_p.A481T	NM_001164508.1	NP_001157980	P20929	NEBU_HUMAN	nebulin	481					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTTAATTGCTTCATATTCT	0.373000													5	35					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	131010949	131010949	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:131010949C>G	ENST00000341179.7	+	19	2085	c.1993C>G	c.(1993-1995)Ctt>Gtt	p.L665V	DNM1_ENST00000475805.1_Missense_Mutation_p.L665V|DNM1_ENST00000486160.1_Missense_Mutation_p.L665V|DNM1_ENST00000393594.3_Missense_Mutation_p.L665V|DNM1_ENST00000372923.3_Missense_Mutation_p.L665V	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	665	GED.				receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						CATCCGGAATCTTGTGGACTC	0.542000													7	157					0	0	1	0	0
C2orf43	60526	broad.mit.edu	37	2	20939904	20939904	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:20939904C>T	ENST00000237822.3	-	5	609	c.530G>A	c.(529-531)aGa>aAa	p.R177K	C2orf43_ENST00000381090.3_Missense_Mutation_p.R177K|C2orf43_ENST00000403006.2_Missense_Mutation_p.R47K|C2orf43_ENST00000435420.2_Missense_Mutation_p.R129K|C2orf43_ENST00000440866.2_Intron|C2orf43_ENST00000541941.1_Missense_Mutation_p.R47K	NM_001282721.1|NM_021925.2	NP_001269650.1|NP_068744.1	Q9H6V9	CB043_HUMAN	chromosome 2 open reading frame 43	177										endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|stomach(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTGGCAATTCTGCCATTGGG	0.403000													16	60					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47408207	47408207	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:47408207C>T	ENST00000398879.1	-	17	2402	c.2036G>A	c.(2035-2037)gGc>gAc	p.G679D	TNS3_ENST00000311160.9_Missense_Mutation_p.G679D|TNS3_ENST00000355730.3_Missense_Mutation_p.G439D			Q68CZ2	TENS3_HUMAN	tensin 3	679			G -> S (in dbSNP:rs7808646).			focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						CAGCTCTGGGCCGGCTCCATT	0.632000													26	183					0	0	1	0	0
OXR1	55074	broad.mit.edu	37	8	107718944	107718944	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:107718944G>C	ENST00000445937.1	+	9	1456	c.1195G>C	c.(1195-1197)Gaa>Caa	p.E399Q	OXR1_ENST00000517566.2_Missense_Mutation_p.E399Q|OXR1_ENST00000442977.2_Missense_Mutation_p.E400Q|OXR1_ENST00000452423.2_5'UTR|OXR1_ENST00000531443.1_Missense_Mutation_p.E399Q|OXR1_ENST00000497705.1_Missense_Mutation_p.E332Q|OXR1_ENST00000312046.6_Missense_Mutation_p.E392Q	NM_018002.3	NP_060472.2	Q8N573	OXR1_HUMAN	oxidation resistance 1	400					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion				NS(2)|breast(2)|endometrium(2)|large_intestine(9)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			ATCTGATACTGAACATTCTAC	0.363000													8	63					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152277373	152277373	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:152277373C>G	ENST00000368799.1	-	3	10024	c.9989G>C	c.(9988-9990)aGt>aCt	p.S3330T	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3330	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGTGTCTACTGTCTCTGAC	0.577000									Ichthyosis				90	441					0	0	1	0	0
ZNF600	162966	broad.mit.edu	37	19	53270675	53270675	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:53270675C>G	ENST00000338230.3	-	3	601	c.334G>C	c.(334-336)Gag>Cag	p.E112Q		NM_198457.2	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		GTAGACTTCTCAAATTGATTA	0.383000													8	193					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152467029	152467029	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:152467029C>T	ENST00000397345.3	-	80	12221		c.e80+1		NEB_ENST00000604864.1_Splice_Site|NEB_ENST00000172853.10_Splice_Site|NEB_ENST00000427231.2_Splice_Site|NEB_ENST00000603639.1_Splice_Site|NEB_ENST00000409198.1_Splice_Site	NM_001164508.1	NP_001157980	P20929	NEBU_HUMAN	nebulin						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		AAGGTACTCACGTCACTGGCG	0.493000													9	55					0	0	1	0	0
COQ5	84274	broad.mit.edu	37	12	120966937	120966937	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:120966937G>A	ENST00000288532.6	-	1	48	c.8C>T	c.(7-9)gCc>gTc	p.A3V	COQ5_ENST00000445328.2_Missense_Mutation_p.A3V	NM_032314.3	NP_115690.3	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	3					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(3)	20	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTCCCGGGGGCCGCCATCTT	0.657000													7	18					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092503	30092503	+	RNA	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:30092503G>T	ENST00000567636.1	+	0	878					NR_003558.1																						TAGGTGAGATGAAGGCATGGT	0.527000													4	81					0.150653	0.151538	1	1	0
SMCHD1	23347	broad.mit.edu	37	18	2762210	2762210	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:2762210C>A	ENST00000320876.6	+	36	4880	c.4542C>A	c.(4540-4542)gtC>gtA	p.V1514V	SMCHD1_ENST00000261598.8_Silent_p.V1514V|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1514					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						GGACCTTGGTCAGAGATCTAC	0.363000													11	49					5.16669e-11	5.98846e-11	1	1	0
UBR4	23352	broad.mit.edu	37	1	19439088	19439088	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:19439088C>G	ENST00000375267.2	-	78	11734	c.11731G>C	c.(11731-11733)Gat>Cat	p.D3911H	UBR4_ENST00000375218.3_3'UTR|UBR4_ENST00000375226.2_Missense_Mutation_p.D3887H|UBR4_ENST00000375254.3_Missense_Mutation_p.D3911H|UBR4_ENST00000375217.2_Missense_Mutation_p.D3904H			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	3911					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGATTATAATCAAAGAGCTCC	0.577000													10	46					0	0	1	0	0
DNAJC28	54943	broad.mit.edu	37	21	34860871	34860871	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr21:34860871G>C	ENST00000314399.3	-	2	1268	c.830C>G	c.(829-831)tCt>tGt	p.S277C	DNAJC28_ENST00000381947.3_Missense_Mutation_p.S277C|DNAJC28_ENST00000402202.1_Missense_Mutation_p.S277C	NM_017833.3	NP_060303.2	Q9NX36	DJC28_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 28	277							heat shock protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(5)|skin(1)|urinary_tract(1)	18						TTTTTTCCTAGACACTAAAAT	0.373000													4	134					0	0	1	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100657184	100657184	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:100657184T>C	ENST00000268070.4	-	13	1861	c.1756A>G	c.(1756-1758)Agt>Ggt	p.S586G		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	586	TSP type-1 1.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		TGTTCTACACTGGCACCCGGG	0.627000													4	22					0	0	1	0	0
MAP3K7	6885	broad.mit.edu	37	6	91281501	91281501	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:91281501A>T	ENST00000369329.3	-	2	307	c.146T>A	c.(145-147)gTt>gAt	p.V49D	MAP3K7_ENST00000369332.3_Missense_Mutation_p.V49D|MAP3K7_ENST00000369325.3_Missense_Mutation_p.V49D|MAP3K7_ENST00000369327.3_Missense_Mutation_p.V49D	NM_145331.2	NP_663304.1	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	49	Protein kinase.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		TTTGCAAACAACTCCAAAGGC	0.353000													3	50					0	0	1	0	0
RAD17	5884	broad.mit.edu	37	5	68682081	68682081	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:68682081G>T	ENST00000509734.1	+	9	1484	c.806G>T	c.(805-807)aGg>aTg	p.R269M	RAD17_ENST00000521422.1_Missense_Mutation_p.R93M|RAD17_ENST00000354868.5_Missense_Mutation_p.R258M|RAD17_ENST00000305138.4_Missense_Mutation_p.R258M|RAD17_ENST00000380774.3_Missense_Mutation_p.R269M|RAD17_ENST00000282891.6_Missense_Mutation_p.R172M|RAD17_ENST00000354312.3_Missense_Mutation_p.R258M|RAD17_ENST00000504177.1_Intron|RAD17_ENST00000358030.2_Missense_Mutation_p.R93M|RAD17_ENST00000345306.6_Missense_Mutation_p.R258M|RAD17_ENST00000361732.2_Missense_Mutation_p.R258M			O75943	RAD17_HUMAN	RAD17 homolog (S. pombe)	269					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding						Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		AATAATCAAAGGTTATTGTTT	0.303000								Other conserved DNA damage response genes					12	107					1.08611e-07	1.23176e-07	1	1	0
AP5S1	55317	broad.mit.edu	37	20	3804755	3804755	+	Silent	SNP	G	G	A	rs141669377	byFrequency	TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:3804755G>A	ENST00000246041.2	+	3	633	c.414G>A	c.(412-414)acG>acA	p.T138T	AP5S1_ENST00000379567.2_Silent_p.T138T|AP5S1_ENST00000379573.2_3'UTR			Q9NUS5	CT029_HUMAN	adaptor-related protein complex 5, sigma 1 subunit	138					double-strand break repair via homologous recombination		protein binding										CTGAGGGCACGCTCCGGCTGC	0.662000													8	26					0	0	1	0	0
TBC1D15	64786	broad.mit.edu	37	12	72274297	72274297	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:72274297C>G	ENST00000550746.1	+	4	317	c.253C>G	c.(253-255)Cat>Gat	p.H85D	TBC1D15_ENST00000393309.3_5'UTR|TBC1D15_ENST00000485960.2_Missense_Mutation_p.H85D|TBC1D15_ENST00000319106.8_Missense_Mutation_p.H93D	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	85							protein binding|Rab GTPase activator activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGAAAGAGGTCATCGAGGATC	0.328000													5	16					0	0	1	0	0
PDHA1	5160	broad.mit.edu	37	X	19371236	19371236	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:19371236C>T	ENST00000379806.5	+	6	714	c.569C>T	c.(568-570)tCg>tTg	p.S190L	PDHA1_ENST00000422285.2_Missense_Mutation_p.S152L|PDHA1_ENST00000540249.1_Missense_Mutation_p.S152L|PDHA1_ENST00000379805.3_Missense_Mutation_p.S152L|PDHA1_ENST00000545074.1_Missense_Mutation_p.S159L	NM_001173454.1	NP_001166925.1	P08559	ODPA_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 1	152					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)	18	Hepatocellular(33;0.183)				NADH(DB00157)	AAAGGAGGATCGATGCACATG	0.498000													13	53					0	0	1	0	0
FABP12	646486	broad.mit.edu	37	8	82439285	82439285	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:82439285C>T	ENST00000360464.4	-	3	380	c.318G>A	c.(316-318)acG>acA	p.T106T	RP11-257P3.3_ENST00000523380.1_RNA	NM_001105281.1	NP_001098751.1	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	106							lipid binding|transporter activity			large_intestine(1)|lung(3)	4						CCAGCTTTCTCGTTATGGTGG	0.413000													5	22					0	0	1	0	0
PPP1R3C	5507	broad.mit.edu	37	10	93390004	93390004	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:93390004C>G	ENST00000238994.5	-	2	718	c.634G>C	c.(634-636)Gat>Cat	p.D212H		NM_005398.5	NP_005389.1	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory subunit 3C	212	CBM21.|Interaction with EPM2A.						protein serine/threonine phosphatase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(1)	12		Colorectal(252;0.235)				GTATCACTATCTGTGCCACCA	0.398000													17	70					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6096551	6096551	+	Missense_Mutation	SNP	G	G	A	rs141690919		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:6096551G>A	ENST00000217289.4	-	3	1080	c.292C>T	c.(292-294)Cgc>Tgc	p.R98C	FERMT1_ENST00000536936.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	98	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						AGACGAAGGCGCAGCATTTTA	0.478000													15	81					0	0	1	0	0
ZNF829	374899	broad.mit.edu	37	19	37382527	37382527	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:37382527A>G	ENST00000520965.1	-	6	1475	c.1409T>C	c.(1408-1410)tTt>tCt	p.F470S	ZNF829_ENST00000391711.3_Missense_Mutation_p.F389S|ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000432005.2_Intron	NM_001171979.1	NP_001165450.1	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GCCTTTATTAAAGGCCTTCCC	0.393000													18	72					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	41988718	41988718	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:41988718G>A	ENST00000219905.7	+	3	1691	c.1510G>A	c.(1510-1512)Gaa>Aaa	p.E504K	MGA_ENST00000570161.1_Missense_Mutation_p.E504K|MGA_ENST00000568630.1_3'UTR|MGA_ENST00000545763.1_Missense_Mutation_p.E504K|MGA_ENST00000389936.4_Missense_Mutation_p.E504K|MGA_ENST00000566586.1_Missense_Mutation_p.E504K	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	504						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TATGTTGGCAGAATTGGAATA	0.408000													11	62					0	0	1	0	0
PIWIL2	55124	broad.mit.edu	37	8	22210508	22210508	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:22210508C>G	ENST00000356766.6	+	21	2588	c.2440C>G	c.(2440-2442)Cgt>Ggt	p.R814G	PIWIL2_ENST00000521356.1_Missense_Mutation_p.R814G|PIWIL2_ENST00000454009.2_Missense_Mutation_p.R814G	NM_018068.3	NP_060538.2	Q8TC59	PIWL2_HUMAN	piwi-like RNA-mediated gene silencing 2	814	Piwi.				DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(14)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	46				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		TGTGGTGTACCGTGATGGAGT	0.478000													8	40					0	0	1	0	0
SERPINE1	5054	broad.mit.edu	37	7	100773885	100773885	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:100773885T>C	ENST00000223095.4	+	3	612	c.455T>C	c.(454-456)gTg>gCg	p.V152A	SERPINE1_ENST00000445463.2_Missense_Mutation_p.V137A	NM_000602.4	NP_000593.1	P05121	PAI1_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	152					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)	20	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	TTTTCAGAGGTGGAGAGAGCC	0.542000													15	214					0	0	1	0	0
RMDN1	51115	broad.mit.edu	37	8	87498829	87498829	+	Missense_Mutation	SNP	C	C	T	rs78015199		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:87498829C>T	ENST00000406452.3	-	4	538	c.379G>A	c.(379-381)Gat>Aat	p.D127N	RMDN1_ENST00000523911.1_Missense_Mutation_p.D83N|RMDN1_ENST00000519966.1_Missense_Mutation_p.D127N|RMDN1_ENST00000430676.2_Missense_Mutation_p.D127N|CPNE3_ENST00000198765.4_Intron	NM_016033.2	NP_057117.2			regulator of microtubule dynamics 1																		TGAGCTACATCACGTGATGCC	0.368000													15	88					0	0	1	0	0
NUFIP2	57532	broad.mit.edu	37	17	27613641	27613641	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:27613641C>T	ENST00000225388.4	-	2	1429	c.1371G>A	c.(1369-1371)atG>atA	p.M457I	NUFIP2_ENST00000579665.1_Intron	NM_020772.2	NP_065823.1	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein interacting protein 2	457						nucleus|polysomal ribosome	protein binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	24			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			AAGTTAGACTCATGTCCTGGA	0.433000													13	89					0	0	1	0	0
FOXN3	1112	broad.mit.edu	37	14	89647108	89647108	+	Missense_Mutation	SNP	C	C	T	rs140477845		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:89647108C>T	ENST00000345097.4	-	6	970	c.854G>A	c.(853-855)cGa>cAa	p.R285Q	FOXN3_ENST00000557258.1_Missense_Mutation_p.R263Q|FOXN3_ENST00000261302.5_Missense_Mutation_p.R285Q|FOXN3_ENST00000555353.1_Missense_Mutation_p.R263Q	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	285					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						AAACAGCCCTCGGCTCAGGAC	0.592000													6	28					0	0	1	0	0
S100A7	6278	broad.mit.edu	37	1	153430437	153430437	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:153430437C>T	ENST00000368723.3	-	3	261	c.151G>A	c.(151-153)Ggc>Agc	p.G51S	S100A7_ENST00000368722.1_Missense_Mutation_p.G51S	NM_002963.3	NP_002954.2	P31151	S10A7_HUMAN	S100 calcium binding protein A7	51	EF-hand 2.				angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TAATTTGTGCCCTTTTTGTCC	0.413000													20	65					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19673943	19673943	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:19673943G>A	ENST00000328041.6	+	13	1562	c.1365G>A	c.(1363-1365)ccG>ccA	p.P455P	RP4-718D20.3_ENST00000598694.1_RNA|RP4-718D20.3_ENST00000609846.1_RNA|RP4-718D20.3_ENST00000435992.2_RNA|RP4-718D20.3_ENST00000600889.1_RNA|RP4-718D20.3_ENST00000608476.1_RNA|RP4-718D20.3_ENST00000609610.1_RNA|RP4-718D20.3_ENST00000593770.1_RNA	NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	455						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TCACCTGGCCGCTGAGTTTCG	0.458000											OREG0025804	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	70					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904324	55904324	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:55904324T>G	ENST00000301529.1	-	1	870	c.871A>C	c.(871-873)Agc>Cgc	p.S291R		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					TTCCTCAGGCTGTAGATCAAG	0.353000													12	62					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070607	114070607	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:114070607T>C	ENST00000462705.1	-	11	920	c.99A>G	c.(97-99)gtA>gtG	p.V33V	ZBTB20_ENST00000357258.3_Silent_p.V33V|ZBTB20_ENST00000471418.1_Silent_p.V33V|ZBTB20_ENST00000393785.2_Silent_p.V33V|ZBTB20_ENST00000481632.1_Silent_p.V33V|ZBTB20_ENST00000464560.1_Silent_p.V33V|ZBTB20_ENST00000474710.1_Silent_p.V106V	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	106					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		TGCGCACCGTTACGTCACAGA	0.607000													4	48					0	0	1	0	0
MTMR2	8898	broad.mit.edu	37	11	95598836	95598836	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:95598836A>G	ENST00000346299.5	-	3	531	c.191T>C	c.(190-192)cTg>cCg	p.L64P	MTMR2_ENST00000409459.1_5'UTR|MTMR2_ENST00000393223.3_5'UTR|MTMR2_ENST00000352297.7_5'UTR|MTMR2_ENST00000484818.1_5'UTR	NM_016156.5	NP_057240.3	Q13614	MTMR2_HUMAN	myotubularin related protein 2	64						nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	19		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AGACTCCCTCAGGACCTGGGG	0.363000													4	74					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21062353	21062353	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:21062353C>T	ENST00000255882.6	-	55	6377	c.6291G>A	c.(6289-6291)caG>caA	p.Q2097Q	PI4KA_ENST00000414196.3_Silent_p.Q849Q|PI4KA_ENST00000572273.1_Silent_p.Q2039Q	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	2039					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding	p.Q2039Q(2)		breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GGATGTCATTCTGATAGTACT	0.602000													19	71					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36006473	36006473	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr13:36006473C>T	ENST00000540320.1	+	39	6781	c.6247C>T	c.(6247-6249)Cgc>Tgc	p.R2083C	NBEA_ENST00000400445.3_Missense_Mutation_p.R2083C|NBEA_ENST00000310336.4_Missense_Mutation_p.R2083C|NBEA_ENST00000379939.2_Missense_Mutation_p.R2080C			Q8NFP9	NBEA_HUMAN	neurobeachin	2083						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding	p.R2083C(1)		NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ACGATTTGTTCGCAATGCATT	0.408000													4	20					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92577489	92577489	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:92577489C>A	ENST00000298047.6	+	18	10973	c.10956C>A	c.(10954-10956)cgC>cgA	p.R3652R	FAT3_ENST00000409404.2_Silent_p.R3652R|FAT3_ENST00000525166.1_Silent_p.R3502R			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3652	Cadherin 33.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCACCATCCGCTTTGAAAATG	0.567000										TCGA Ovarian(4;0.039)			6	90					0.00116845	0.0012201	1	1	0
SLC52A3	113278	broad.mit.edu	37	20	744203	744203	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:744203C>T	ENST00000381944.3	-	3	1253	c.1012G>A	c.(1012-1014)Gcc>Acc	p.A338T	SLC52A3_ENST00000217254.7_Missense_Mutation_p.A338T|SLC52A3_ENST00000473664.1_Intron			Q9NQ40	RFT2_HUMAN	solute carrier family 52 (riboflavin transporter), member 3	338					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity										CTGAGGGTGGCAGCCAGGTGG	0.602000													13	51					0	0	1	0	0
U2SURP	23350	broad.mit.edu	37	3	142741354	142741354	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:142741354C>A	ENST00000473835.2	+	11	958	c.868C>A	c.(868-870)Ctg>Atg	p.L290M	U2SURP_ENST00000397933.2_5'UTR|U2SURP_ENST00000493598.2_Missense_Mutation_p.L289M	NM_001080415.1	NP_001073884.1	O15042	SR140_HUMAN	U2 snRNP-associated SURP domain containing	290	RRM.				RNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	31						TGAAGAAATGCTGTGCCAAGA	0.328000													16	57					2.48551e-13	2.91536e-13	1	1	0
CGN	57530	broad.mit.edu	37	1	151502552	151502552	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:151502552G>A	ENST00000271636.7	+	12	2407	c.2274G>A	c.(2272-2274)gcG>gcA	p.A758A		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	752	Glu-rich.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTGGGGAAGCGGTGGAGGCAC	0.602000													11	52					0	0	1	0	0
SHCBP1	79801	broad.mit.edu	37	16	46617538	46617538	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:46617538T>C	ENST00000303383.3	-	12	1849	c.1583A>G	c.(1582-1584)aAg>aGg	p.K528R		NM_024745.4	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	528										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				CATGGATATCTTGGGAATGTC	0.328000													53	122					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331490	85331490	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:85331490C>T	ENST00000440886.1	-	1	352	c.314G>A	c.(313-315)cGt>cAt	p.R105H	LPAR3_ENST00000370611.3_Missense_Mutation_p.R105H|LPAR3_ENST00000491034.1_5'UTR			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	105					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						AAGCCCCTGACGGAGAAACCA	0.502000													5	211					0	0	1	0	0
C1orf174	339448	broad.mit.edu	37	1	3807332	3807332	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:3807332G>A	ENST00000361605.3	-	3	517	c.419C>T	c.(418-420)tCc>tTc	p.S140F	C1orf174_ENST00000486765.1_5'UTR	NM_207356.2	NP_997239.2	Q8IYL3	CA174_HUMAN	chromosome 1 open reading frame 174	140										endometrium(1)|large_intestine(5)|lung(4)|prostate(1)	11	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_cancers(23;5.09e-25)|all_epithelial(116;9.35e-17)|all_lung(118;1.09e-06)|Lung NSC(185;0.000139)|all_neural(13;0.00287)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0219)|all_hematologic(16;0.027)|Colorectal(325;0.0276)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;1.55e-39)|OV - Ovarian serous cystadenocarcinoma(86;5.99e-23)|GBM - Glioblastoma multiforme(42;2.22e-17)|Colorectal(212;1.08e-05)|COAD - Colon adenocarcinoma(227;5.49e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000365)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.19)		TTTTGGCACGGACAGGCCATC	0.572000													9	42					0	0	1	0	0
MAN1A2	10905	broad.mit.edu	37	1	118065449	118065449	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:118065449A>T	ENST00000356554.3	+	13	2531	c.1796A>T	c.(1795-1797)tAt>tTt	p.Y599F		NM_006699.3	NP_006690.1	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	599					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	27	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		ATTTTCAGATATTTGTATCTG	0.393000													9	106					0	0	1	0	0
HIPK1	204851	broad.mit.edu	37	1	114511080	114511080	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:114511080C>A	ENST00000369558.1	+	13	2813	c.2581C>A	c.(2581-2583)Ctg>Atg	p.L861M	HIPK1_ENST00000406344.1_Missense_Mutation_p.L467M|HIPK1_ENST00000369561.4_Missense_Mutation_p.L827M|HIPK1_ENST00000426820.2_Missense_Mutation_p.L861M|HIPK1_ENST00000369555.2_Missense_Mutation_p.L816M|HIPK1_ENST00000369559.4_Missense_Mutation_p.L861M|HIPK1_ENST00000369554.2_Missense_Mutation_p.L816M|HIPK1_ENST00000369553.1_Missense_Mutation_p.L467M|HIPK1_ENST00000340480.4_Missense_Mutation_p.L487M			Q86Z02	HIPK1_HUMAN	homeodomain interacting protein kinase 1	861					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTAGATGTTCTGCCTTCCCA	0.463000													14	93					5.01169e-05	5.38934e-05	1	1	0
HIST1H4C	8364	broad.mit.edu	37	6	26104345	26104345	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:26104345G>T	ENST00000377803.2	+	1	242	c.170G>T	c.(169-171)gGt>gTt	p.G57V		NM_003542.3	NP_003533.1	P62805	H4_HUMAN	histone cluster 1, H4c	57					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)	7						GAGACTCGAGGTGTGCTTAAG	0.522000													13	67					4.3838e-07	4.89072e-07	1	1	0
NHLRC4	283948	broad.mit.edu	37	16	618117	618117	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:618117T>A	ENST00000424439.2	+	2	727	c.70T>A	c.(70-72)Ttt>Att	p.F24I	PIGQ_ENST00000409527.2_Intron|NHLRC4_ENST00000540585.1_Missense_Mutation_p.F24I			P0CG21	NHLC4_HUMAN	NHL repeat containing 4	24																	GAGTGAGGAGTTTGGGGATGT	0.692000													5	15					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112177244	112177244	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:112177244G>A	ENST00000457016.1	+	16	6333	c.5953G>A	c.(5953-5955)Gaa>Aaa	p.E1985K	APC_ENST00000508376.2_Missense_Mutation_p.E1985K|APC_ENST00000257430.4_Missense_Mutation_p.E1985K|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	1985	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TAAAGAAAATGAACCTATCAA	0.398000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			12	44					0	0	1	0	0
NAGK	55577	broad.mit.edu	37	2	71299818	71299818	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:71299818A>G	ENST00000418807.3	+	4	414	c.250A>G	c.(250-252)Aac>Gac	p.N84D	NAGK_ENST00000428360.2_3'UTR|NAGK_ENST00000443872.2_5'UTR|NAGK_ENST00000443938.2_Missense_Mutation_p.N135D|NAGK_ENST00000455662.2_Missense_Mutation_p.N181D|NAGK_ENST00000244204.6_Missense_Mutation_p.N135D			Q9UJ70	NAGK_HUMAN	N-acetylglucosamine kinase	135					N-acetylglucosamine metabolic process|N-acetylmannosamine metabolic process		ATP binding|N-acetylglucosamine kinase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|urinary_tract(1)	18					N-Acetyl-D-glucosamine(DB00141)	CAGGCTCATCAACCCTGATGG	0.602000													3	28					0	0	1	0	0
OXNAD1	92106	broad.mit.edu	37	3	16327924	16327924	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:16327924G>A	ENST00000285083.5	+	5	724	c.259G>A	c.(259-261)Gat>Aat	p.D87N	OXNAD1_ENST00000435829.2_Missense_Mutation_p.D105N|OXNAD1_ENST00000544043.1_Missense_Mutation_p.D105N|OXNAD1_ENST00000605932.1_Missense_Mutation_p.D87N|OXNAD1_ENST00000606098.1_Missense_Mutation_p.D87N	NM_138381.3	NP_612390.1	Q96HP4	OXND1_HUMAN	oxidoreductase NAD-binding domain containing 1	87	FAD-binding FR-type.						oxidoreductase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|skin(2)	13						GCTTGTTGCTGATCAAGACTT	0.443000													12	44					0	0	1	0	0
CSH2	1443	broad.mit.edu	37	17	61950662	61950662	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:61950662G>T	ENST00000336844.5	-	2	199	c.48C>A	c.(46-48)ctC>ctA	p.L16L	CSH2_ENST00000560142.1_Silent_p.L16L|CSH2_ENST00000392886.2_Silent_p.L16L|CSH2_ENST00000345366.7_Silent_p.L16L	NM_022644.3	NP_072170.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2	16					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			endometrium(2)|large_intestine(1)|lung(3)	6						AGGGCAGGCAGAGCAGGGCAA	0.642000													8	84					5.4927e-09	6.29181e-09	1	1	0
TBC1D10B	26000	broad.mit.edu	37	16	30369984	30369984	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:30369984C>G	ENST00000409939.3	-	8	1877	c.1797G>C	c.(1795-1797)gaG>gaC	p.E599D		NM_015527.3	NP_056342.3	Q4KMP7	TB10B_HUMAN	TBC1 domain family, member 10B	599						cytoplasm	Rab GTPase activator activity			endometrium(2)|kidney(1)|lung(2)|urinary_tract(1)	6			Colorectal(24;0.193)			ACAGGCCTACCTCATGCACCA	0.602000													3	12					0	0	1	0	0
DNAJC21	134218	broad.mit.edu	37	5	34954775	34954775	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:34954775G>A	ENST00000382021.2	+	13	1914	c.1687G>A	c.(1687-1689)Gca>Aca	p.A563T	DNAJC21_ENST00000303525.7_Missense_Mutation_p.A531T|DNAJC21_ENST00000342382.4_Missense_Mutation_p.A518T	NM_194283.3	NP_919259.3	Q5F1R6	DJC21_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 21	518					protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			TTTAAACAGCGCAACAAGTAG	0.388000													14	78					0	0	1	0	0
DPY19L3	147991	broad.mit.edu	37	19	32902171	32902171	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:32902171A>G	ENST00000342179.5	+	3	345	c.130A>G	c.(130-132)Att>Gtt	p.I44V	DPY19L3_ENST00000392250.2_Missense_Mutation_p.I44V|DPY19L3_ENST00000586987.1_Missense_Mutation_p.I44V|DPY19L3_ENST00000587077.2_Missense_Mutation_p.I44V	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	44						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					ATTATGGAAGATTTTGTCATT	0.328000													4	62					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35518832	35518832	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:35518832T>C	ENST00000353139.5	-	42	5693	c.5212A>G	c.(5212-5214)Aga>Gga	p.R1738G	ACACA_ENST00000394406.2_Missense_Mutation_p.R1701G|ACACA_ENST00000335166.5_Missense_Mutation_p.R1623G|ACACA_ENST00000360679.3_Missense_Mutation_p.R1643G	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	1701	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TCGGAAGCTCTGAGAAATAAC	0.448000													11	77					0	0	1	0	0
NRN1L	123904	broad.mit.edu	37	16	67919746	67919746	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:67919746G>A	ENST00000339176.3	+	2	300	c.201G>A	c.(199-201)gaG>gaA	p.E67E	NRN1L_ENST00000576147.1_5'UTR|CTC-479C5.10_ENST00000572067.1_lincRNA	NM_198443.1	NP_940845.1	Q496H8	NRN1L_HUMAN	neuritin 1-like	67						anchored to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)	7		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		GCGAGCTGGAGACCATCTGCA	0.607000													8	73					0	0	1	0	0
MELK	9833	broad.mit.edu	37	9	36630325	36630325	+	Silent	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:36630325C>G	ENST00000543751.1	+	8	745	c.600C>G	c.(598-600)ctC>ctG	p.L200L	MELK_ENST00000536860.1_Silent_p.L184L|MELK_ENST00000536987.1_Silent_p.L101L|MELK_ENST00000538311.1_Silent_p.L38L|MELK_ENST00000541717.1_Silent_p.L232L|MELK_ENST00000487398.1_3'UTR|MELK_ENST00000298048.2_Silent_p.L232L|MELK_ENST00000536329.1_Silent_p.L161L|MELK_ENST00000545008.1_Silent_p.L161L	NM_001256689.1	NP_001243618.1	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	232	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			CCAAGTGGCTCTCTCCCAGTA	0.333000													6	170					0	0	1	0	0
COBLL1	22837	broad.mit.edu	37	2	165578680	165578680	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:165578680G>A	ENST00000375458.2	-	6	1122	c.901C>T	c.(901-903)Cca>Tca	p.P301S	COBLL1_ENST00000392717.2_Missense_Mutation_p.P339S|COBLL1_ENST00000409184.3_Missense_Mutation_p.P339S|COBLL1_ENST00000491126.2_Intron|COBLL1_ENST00000194871.6_Missense_Mutation_p.P367S|COBLL1_ENST00000342193.4_Missense_Mutation_p.P301S	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	339										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						TGAGATGCTGGCATCGGGGGC	0.522000													11	59					0	0	1	0	0
ZFP14	57677	broad.mit.edu	37	19	36851383	36851383	+	Missense_Mutation	SNP	C	C	A	rs150854351		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:36851383C>A	ENST00000270001.7	-	4	304	c.189G>T	c.(187-189)aaG>aaT	p.K63N	ZFP14_ENST00000589280.1_Missense_Mutation_p.K64N	NM_020917.2	NP_065968.1	Q9HCL3	ZFP14_HUMAN	ZFP14 zinc finger protein	63	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					TCCCAGGTTCCTTCCTTTCTT	0.418000													9	47					0.010729	0.0110351	1	1	0
THYN1	29087	broad.mit.edu	37	11	134118854	134118854	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:134118854C>T	ENST00000341541.3	-	6	942		c.e6-1		THYN1_ENST00000392595.2_Splice_Site|THYN1_ENST00000392594.3_Splice_Site|THYN1_ENST00000352327.5_Intron	NM_014174.2	NP_054893.1	Q9P016	THYN1_HUMAN	thymocyte nuclear protein 1							nucleus				endometrium(2)|kidney(1)|lung(3)|pancreas(1)	7	all_hematologic(175;0.127)	all_cancers(12;1.1e-21)|all_epithelial(12;3.77e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;1.68e-10)|all cancers(11;1.95e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00148)|Lung(977;0.207)		GTACATCCACCTATGTGACAA	0.463000													19	71					0	0	1	0	0
VPREB3	29802	broad.mit.edu	37	22	24095144	24095144	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:24095144G>T	ENST00000248948.3	-	2	395	c.291C>A	c.(289-291)gcC>gcA	p.A97A	VPREB3_ENST00000398465.3_Silent_p.A81A	NM_013378.2	NP_037510.1	Q9UKI3	VPRE3_HUMAN	pre-B lymphocyte 3	97	Ig-like.					endoplasmic reticulum				large_intestine(1)|lung(1)|skin(1)	3		Medulloblastoma(6;7.87e-06)|all_neural(6;0.00334)				TGAGGACACAGGCATTGTGGG	0.592000													8	34					0.000157383	0.000167925	1	1	0
TMEM106A	113277	broad.mit.edu	37	17	41367889	41367889	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:41367889A>G	ENST00000331615.3	+	5	595	c.358A>G	c.(358-360)Att>Gtt	p.I120V	TMEM106A_ENST00000588659.1_Missense_Mutation_p.I120V|TMEM106A_ENST00000536052.1_Missense_Mutation_p.I120V|TMEM106A_ENST00000592564.1_3'UTR|TMEM106A_ENST00000541594.1_Missense_Mutation_p.I72V	NM_145041.1	NP_659478.1	Q96A25	T106A_HUMAN	transmembrane protein 106A	120						integral to membrane				NS(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11		Breast(137;0.0164)		BRCA - Breast invasive adenocarcinoma(366;0.0917)		CCGGTCCGTCATTGTGCAGCC	0.567000													35	170					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12315827	12315827	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:12315827C>A	ENST00000256186.2	+	3	1140	c.849C>A	c.(847-849)ccC>ccA	p.P283P		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	283					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		CTCTAGAGCCCCTCCTTTCCA	0.587000													8	25					1.12685e-05	1.23701e-05	1	1	0
GABRB2	2561	broad.mit.edu	37	5	160721218	160721218	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:160721218C>T	ENST00000274547.2	-	11	1626	c.1409G>A	c.(1408-1410)cGc>cAc	p.R470H	GABRB2_ENST00000517901.1_Missense_Mutation_p.R369H|GABRB2_ENST00000393959.1_Missense_Mutation_p.R470H|GABRB2_ENST00000517547.1_Missense_Mutation_p.R272H|GABRB2_ENST00000353437.6_Missense_Mutation_p.R432H|GABRB2_ENST00000520240.1_Missense_Mutation_p.R432H	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	470					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTGGGAGGCGCGTCTCCTCAG	0.507000													8	68					0	0	1	0	0
TES	26136	broad.mit.edu	37	7	115892473	115892473	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:115892473C>T	ENST00000358204.4	+	6	1235	c.1020C>T	c.(1018-1020)taC>taT	p.Y340Y	AC002066.1_ENST00000446355.2_RNA|AC073130.3_ENST00000444244.1_RNA|TES_ENST00000393481.2_Silent_p.Y331Y|TES_ENST00000537767.1_Silent_p.Y98Y	NM_015641.3	NP_056456.1	Q9UGI8	TES_HUMAN	testis derived transcript (3 LIM domains)	340	LIM zinc-binding 2.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding			endometrium(4)|large_intestine(4)|lung(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	12	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			GGGAGATATACGTGATGGTCA	0.468000													26	92					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169229287	169229287	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:169229287G>C	ENST00000393743.3	-	4	425	c.134C>G	c.(133-135)tCa>tGa	p.S45*		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	45							ATP binding|ATP-dependent helicase activity|RNA binding	p.S45L(2)		breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		GATAAGTAATGAATCCCCATC	0.308000													13	61					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31566371	31566371	+	Splice_Site	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:31566371T>C	ENST00000389082.5	-	13	2944	c.2680A>G	c.(2680-2682)Aag>Gag	p.K894E	DENND5B_ENST00000536562.1_Splice_Site_p.K929E|DENND5B_ENST00000306833.6_Splice_Site_p.K929E	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	894	RUN 1.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						GTATCTTACTTGGTGAGTGGT	0.413000													5	46					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	187004099	187004099	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:187004099C>G	ENST00000296795.3	+	4	1363	c.1259C>G	c.(1258-1260)tCa>tGa	p.S420*	TLR3_ENST00000504367.1_Nonsense_Mutation_p.S143*	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3						activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		AATAAAATCTCAAAAATAGAG	0.408000													13	63					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50912914	50912914	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:50912914G>T	ENST00000440232.2	+	17	2198	c.2145G>T	c.(2143-2145)gaG>gaT	p.E715D	POLD1_ENST00000595904.1_Missense_Mutation_p.E741D|POLD1_ENST00000599857.1_Missense_Mutation_p.E715D	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	715					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		CGTGCCTGGAGATCTCACAGG	0.667000								DNA polymerases (catalytic subunits)					7	55					3.09899e-07	3.46298e-07	1	1	0
IDE	3416	broad.mit.edu	37	10	94228654	94228654	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:94228654C>G	ENST00000265986.6	-	19	2358	c.2302G>C	c.(2302-2304)Gaa>Caa	p.E768Q	IDE_ENST00000496903.1_5'UTR|IDE_ENST00000371581.5_Missense_Mutation_p.E213Q	NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	768					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGCTGAACTTCTCTATACCGA	0.433000													6	24					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111367	7111367	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:7111367G>A	ENST00000306904.5	+	1	1203	c.1016G>A	c.(1015-1017)gGc>gAc	p.G339D		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	339	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TACTCGAGGGGCCGACACCGG	0.662000													5	20					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102551683	102551683	+	Missense_Mutation	SNP	C	C	G	rs140980766		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:102551683C>G	ENST00000334701.7	-	5	1262	c.981G>C	c.(979-981)gaG>gaC	p.E327D	HSP90AA1_ENST00000441629.2_Missense_Mutation_p.E26D|HSP90AA1_ENST00000216281.8_Missense_Mutation_p.E205D	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	205					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding	p.E327D(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	TCTTCACAATCTCCTTTATTC	0.378000													7	41					0	0	1	0	0
METTL4	64863	broad.mit.edu	37	18	2567049	2567049	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:2567049G>C	ENST00000319888.6	-	2	965	c.167C>G	c.(166-168)tCt>tGt	p.S56C	METTL4_ENST00000574538.1_Missense_Mutation_p.S56C			Q8N3J2	METL4_HUMAN	methyltransferase like 4	56					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						ACAGACTCCAGAGGAGGACAC	0.398000													4	39					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177250038	177250038	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:177250038C>A	ENST00000361539.4	+	8	2038	c.1726C>A	c.(1726-1728)Ctc>Atc	p.L576I	BRINP2_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1			bone morphogenetic protein/retinoic acid inducible neural-specific 2	576																	GCAGATCTGTCTCACCAAGAA	0.572000													5	23					0.000602214	0.000633666	1	1	0
IFT122	55764	broad.mit.edu	37	3	129182458	129182458	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:129182458C>T	ENST00000296266.3	+	7	750	c.558C>T	c.(556-558)atC>atT	p.I186I	IFT122_ENST00000348417.2_Silent_p.I135I|IFT122_ENST00000504021.1_Silent_p.I88I|IFT122_ENST00000507564.1_Silent_p.I186I|IFT122_ENST00000440957.2_5'UTR|IFT122_ENST00000431818.2_5'UTR|IFT122_ENST00000349441.2_Silent_p.I83I|IFT122_ENST00000347300.2_Silent_p.I135I	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	135					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						GCAGCAAGATCATCTGCTGCA	0.408000													5	61					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96127845	96127845	+	Missense_Mutation	SNP	G	G	C	rs142077174		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:96127845G>C	ENST00000453304.1	-	11	2184	c.1836C>G	c.(1834-1836)tgC>tgG	p.C612W		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	612	ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TGGGGTCTGCGCAGTGATGCA	0.572000													19	100					0	0	1	0	0
TGFBR2	7048	broad.mit.edu	37	3	30691947	30691947	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:30691947C>G	ENST00000295754.5	+	3	831	c.449C>G	c.(448-450)tCa>tGa	p.S150*	TGFBR2_ENST00000359013.4_Nonsense_Mutation_p.S175*	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	150					activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						ATCATCTTCTCAGAAGGTGAG	0.433000													10	53					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142459835	142459835	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:142459835G>A	ENST00000486171.1	+	4	470	c.453G>A	c.(451-453)acG>acA	p.T151T	PRSS1_ENST00000311737.7_Silent_p.T137T			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	137	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity	p.T137T(2)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			CCACTGGCACGAAGTGCCTCA	0.552000													18	74					0	0	1	0	0
PPP1R18	170954	broad.mit.edu	37	6	30652939	30652939	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:30652939C>A	ENST00000274853.3	-	1	2733	c.857G>T	c.(856-858)gGg>gTg	p.G286V	PPP1R18_ENST00000399199.3_Missense_Mutation_p.G286V|PPP1R18_ENST00000488324.1_Intron	NM_133471.3	NP_597728.1	Q6NYC8	PHTNS_HUMAN	protein phosphatase 1, regulatory subunit 18	286						cytoplasm|cytoskeleton	actin binding										TGGAGCTACCCCTGGAACTGG	0.557000													19	86					8.34094e-07	9.27523e-07	1	1	0
NTRK2	4915	broad.mit.edu	37	9	87317107	87317107	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:87317107C>A	ENST00000304053.6	+	3	729	c.246C>A	c.(244-246)atC>atA	p.I82I	NTRK2_ENST00000395882.1_Silent_p.I82I|NTRK2_ENST00000277120.3_Silent_p.I82I|NTRK2_ENST00000376208.1_Silent_p.I82I|NTRK2_ENST00000376214.1_Silent_p.I82I|NTRK2_ENST00000395866.2_5'UTR|NTRK2_ENST00000323115.4_Silent_p.I82I|NTRK2_ENST00000376213.1_Silent_p.I82I|NTRK2_ENST00000359847.3_Silent_p.I82I	NM_001018065.2	NP_001018075.1	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	82					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						TAGAAATCATCAACGAAGATG	0.443000										TSP Lung(25;0.17)			6	54					2.0095e-06	2.22736e-06	1	1	0
CACNA1G	8913	broad.mit.edu	37	17	48683430	48683430	+	Missense_Mutation	SNP	G	G	T	rs34008213		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:48683430G>T	ENST00000416767.4	+	23	4496	c.4468G>T	c.(4468-4470)Ggg>Tgg	p.G1490W	CACNA1G_ENST00000514079.1_Intron|CACNA1G_ENST00000507510.2_Intron|CACNA1G_ENST00000442258.2_Intron|CACNA1G_ENST00000507609.1_Intron|CACNA1G_ENST00000505165.1_Intron|CACNA1G_ENST00000513689.2_Intron|CACNA1G_ENST00000514181.1_Intron|CACNA1G_ENST00000507336.1_Intron|CACNA1G_ENST00000512389.1_Intron|CACNA1G_ENST00000510366.1_Intron|CACNA1G_ENST00000359106.5_Intron|CACNA1G_ENST00000510115.1_Intron|CACNA1G_ENST00000515765.1_Intron|CACNA1G_ENST00000507896.1_Intron|CACNA1G_ENST00000503485.1_Intron|CACNA1G_ENST00000354983.4_Intron|CACNA1G_ENST00000515411.1_Intron|CACNA1G_ENST00000502264.1_Intron|CACNA1G_ENST00000514717.1_Intron|CACNA1G_ENST00000429973.2_Intron|CACNA1G_ENST00000513964.1_Intron|CACNA1G_ENST00000360761.4_Intron|CACNA1G_ENST00000358244.5_Intron|CACNA1G_ENST00000515165.1_Intron|CACNA1G_ENST00000352832.5_Intron			O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	979					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGAGGCTGGAGGGGGCACAGG	0.612000													9	37					4.36969e-10	5.03065e-10	1	1	0
CHAF1B	8208	broad.mit.edu	37	21	37785282	37785282	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr21:37785282C>A	ENST00000314103.5	+	12	1313	c.1162C>A	c.(1162-1164)Cca>Aca	p.P388T		NM_005441.2	NP_005432.1	Q13112	CAF1B_HUMAN	chromatin assembly factor 1, subunit B (p60)						cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(2)	20						GAAAGAGAAGCCAGTTTTGAA	0.493000													6	35					8.12818e-05	8.6997e-05	1	1	0
HPR	3250	broad.mit.edu	37	16	72107850	72107850	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:72107850C>A	ENST00000540303.2	+	2	97	c.65C>A	c.(64-66)tCa>tAa	p.S22*	HPR_ENST00000228226.8_Nonsense_Mutation_p.S59*|HPR_ENST00000356967.5_Nonsense_Mutation_p.S22*|HPR_ENST00000561690.1_Nonsense_Mutation_p.S22*	NM_020995.3	NP_066275.3	P00739	HPTR_HUMAN	haptoglobin-related protein	22					proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|stomach(1)|urinary_tract(2)	20		Ovarian(137;0.125)				GCACTGTACTCAGGCAATGAT	0.537000													4	87					0.184627	0.185168	1	1	0
BTAF1	9044	broad.mit.edu	37	10	93778679	93778679	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:93778679C>G	ENST00000265990.6	+	34	5158	c.4850C>G	c.(4849-4851)tCa>tGa	p.S1617*	BTAF1_ENST00000544642.1_Nonsense_Mutation_p.S445*	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	1617					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity	p.S1617*(1)		central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				CCTAAGCTCTCAGCTTTGAAA	0.353000													14	90					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177911106	177911106	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:177911106C>T	ENST00000308284.6	-	16	2040	c.1951G>A	c.(1951-1953)Gaa>Aaa	p.E651K	RP4-798P15.3_ENST00000354921.3_RNA	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	651					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						CCAATGGCTTCGCAGTAATGC	0.507000													8	54					0	0	1	0	0
SNX32	254122	broad.mit.edu	37	11	65620391	65620391	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:65620391C>T	ENST00000308342.6	+	12	1545	c.1120C>T	c.(1120-1122)Ctc>Ttc	p.L374F		NM_152760.2	NP_689973.2	Q86XE0	SNX32_HUMAN	sorting nexin 32	374					cell communication|protein transport		phosphatidylinositol binding			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				READ - Rectum adenocarcinoma(159;0.171)		TCGAAAGAATCTCATTGAGCT	0.627000													13	92					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210557883	210557883	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:210557883A>T	ENST00000360351.4	+	7	1495	c.989A>T	c.(988-990)aAg>aTg	p.K330M	MAP2_ENST00000361559.4_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.K326M|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000392194.1_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	330					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GATGTCATGAAGAATGAAATA	0.438000													8	58					0	0	1	0	0
ACAT1	38	broad.mit.edu	37	11	108009625	108009625	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:108009625G>A	ENST00000265838.4	+	6	527	c.436G>A	c.(436-438)Gat>Aat	p.D146N		NM_000019.3	NP_000010.1	P24752	THIL_HUMAN	acetyl-CoA acetyltransferase 1	146					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(3)|prostate(2)	10		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)	TTCTGCGCAGGATGTGATGGT	0.413000													28	104					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78073343	78073343	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:78073343G>T	ENST00000397545.4	+	20	3225	c.3198G>T	c.(3196-3198)gtG>gtT	p.V1066V		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1066					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CAGAGATCGTGGCCCTGCAGA	0.572000													11	72					4.68919e-08	5.34458e-08	1	1	0
SLIT2	9353	broad.mit.edu	37	4	20544219	20544219	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:20544219C>G	ENST00000504154.1	+	21	2498	c.2246C>G	c.(2245-2247)cCg>cGg	p.P749R	SLIT2_ENST00000273739.5_Missense_Mutation_p.P753R|SLIT2_ENST00000503837.1_Missense_Mutation_p.P745R|SLIT2_ENST00000509394.2_3'UTR|SLIT2_ENST00000503823.1_Missense_Mutation_p.P741R	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	749	LRRNT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding	p.P749>?(1)		NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AAGGTCTTGCCGAAAGGTATT	0.408000													31	150					0	0	1	0	0
ACSL1	2180	broad.mit.edu	37	4	185691610	185691610	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:185691610T>C	ENST00000515030.1	-	11	1261	c.936A>G	c.(934-936)ccA>ccG	p.P312P	ACSL1_ENST00000504342.1_Silent_p.P312P|ACSL1_ENST00000281455.2_Silent_p.P312P|ACSL1_ENST00000504900.1_Silent_p.P312P|ACSL1_ENST00000507295.1_Silent_p.P278P|ACSL1_ENST00000454703.2_Silent_p.P141P|ACSL1_ENST00000513317.1_Intron|ACSL1_ENST00000437665.3_Silent_p.P141P			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	312					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AAGTATCATCTGGGCAAGGAT	0.433000													8	43					0	0	1	0	0
SSRP1	6749	broad.mit.edu	37	11	57094906	57094906	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:57094906G>T	ENST00000278412.2	-	15	2131	c.1865C>A	c.(1864-1866)tCt>tAt	p.S622Y	RP11-872D17.4_ENST00000534162.1_RNA	NM_003146.2	NP_003137.1	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	622					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|prostate(4)	23						TCACCTCTTAGAAGACTCGCC	0.468000													25	129					2.50493e-22	3.00504e-22	1	1	0
ROS1	6098	broad.mit.edu	37	6	117662378	117662378	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:117662378G>A	ENST00000368508.3	-	30	5197	c.4999C>T	c.(4999-5001)Cca>Tca	p.P1667S	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.P1661S	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1667	Fibronectin type-III 8.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GTGTTCTCTGGAACCAAGGAA	0.413000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								18	60					0	0	1	0	0
SLC27A2	11001	broad.mit.edu	37	15	50489836	50489836	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:50489836C>A	ENST00000267842.5	+	2	850	c.618C>A	c.(616-618)atC>atA	p.I206I	SLC27A2_ENST00000380902.4_Silent_p.I206I|SLC27A2_ENST00000544960.1_5'UTR	NM_003645.3	NP_003636.2	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid transporter), member 2	206					bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		CTGAACCTATCCCAGAGTCAT	0.398000													15	57					0.000308642	0.000327783	1	1	0
ADGRG1	9289	broad.mit.edu	37	16	57685486	57685486	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:57685486C>G	ENST00000562631.1	+	3	971	c.439C>G	c.(439-441)Cag>Gag	p.Q147E	GPR56_ENST00000562558.1_Missense_Mutation_p.Q147E|GPR56_ENST00000379696.3_Missense_Mutation_p.Q147E|GPR56_ENST00000456916.1_Missense_Mutation_p.Q147E|GPR56_ENST00000379694.4_Intron|GPR56_ENST00000567835.1_Missense_Mutation_p.Q147E|GPR56_ENST00000568909.1_Missense_Mutation_p.Q147E|GPR56_ENST00000388813.5_Missense_Mutation_p.Q147E|GPR56_ENST00000544297.1_5'UTR|GPR56_ENST00000568908.1_Missense_Mutation_p.Q147E|GPR56_ENST00000538815.1_Missense_Mutation_p.Q147E|GPR56_ENST00000540164.2_Missense_Mutation_p.Q147E|GPR56_ENST00000564912.1_3'UTR|GPR56_ENST00000388812.4_Missense_Mutation_p.Q147E			Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56	147					brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	15						GTGGAGCCCTCAGAACATCAG	0.612000													8	32					0	0	1	0	0
NBPF3	84224	broad.mit.edu	37	1	21798100	21798100	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:21798100T>C	ENST00000318220.6	+	8	1365	c.317T>C	c.(316-318)cTg>cCg	p.L106P	NBPF3_ENST00000454000.2_Missense_Mutation_p.L92P|NBPF3_ENST00000318249.5_Missense_Mutation_p.L162P|NBPF3_ENST00000342104.5_Missense_Mutation_p.L162P			Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	162						cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	20		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GAACGAGAGCTGACCCAGTTA	0.478000													16	213					0	0	1	0	0
RABEP2	79874	broad.mit.edu	37	16	28926079	28926079	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:28926079G>A	ENST00000358201.4	-	4	1045	c.457C>T	c.(457-459)Cgg>Tgg	p.R153W	RABEP2_ENST00000357573.6_Missense_Mutation_p.R153W|RABEP2_ENST00000544477.1_Missense_Mutation_p.R82W	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	153					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						ACGATCTCCCGCAGCTTCTCC	0.622000													11	69					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53573345	53573345	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:53573345C>T	ENST00000601421.1	-	3	1210	c.334G>A	c.(334-336)Gac>Aac	p.D112N	ZNF160_ENST00000418871.1_Missense_Mutation_p.D148N|ZNF160_ENST00000599056.1_Missense_Mutation_p.D148N|ZNF160_ENST00000429604.1_Missense_Mutation_p.D148N			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	148					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		TTTCCTGTGTCATCTCTCCAT	0.423000													21	136					0	0	1	0	0
SKIV2L	6499	broad.mit.edu	37	6	31929329	31929329	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:31929329G>A	ENST00000375394.2	+	9	908	c.795G>A	c.(793-795)gcG>gcA	p.A265A	SKIV2L_ENST00000544581.1_Silent_p.A72A	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	265						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						TCCAGGAAGCGTCCACAGCTG	0.567000													17	83					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15295171	15295171	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:15295171C>T	ENST00000263388.2	-	16	2576	c.2501G>A	c.(2500-2502)aGc>aAc	p.S834N		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	834	EGF-like 21; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			GCAGGTGCAGCTGAAACTCCC	0.627000													5	28					0	0	1	0	0
ASAH2	56624	broad.mit.edu	37	10	52003077	52003077	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:52003077C>T	ENST00000395526.4	-	3	394	c.395G>A	c.(394-396)gGc>gAc	p.G132D	ASAH2_ENST00000447815.1_Missense_Mutation_p.G132D|ASAH2_ENST00000329428.6_Missense_Mutation_p.G113D	NM_019893.2	NP_063946.2	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2						apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity			large_intestine(1)|lung(9)|urinary_tract(1)	11						GGTGAGGATGCCCTGTGCATT	0.498000													7	63					0	0	1	0	0
MMS22L	253714	broad.mit.edu	37	6	97626452	97626452	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:97626452T>C	ENST00000275053.4	-	18	2811	c.2546A>G	c.(2545-2547)tAc>tGc	p.Y849C	MMS22L_ENST00000369251.2_Missense_Mutation_p.Y809C	NM_198468.2	NP_940870.2	Q6ZRQ5	MMS22_HUMAN	MMS22-like, DNA repair protein	849					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding			breast(1)|endometrium(9)|kidney(2)|large_intestine(12)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	50						CTGTTTCATGTACTCTTTTTC	0.254000													13	43					0	0	1	0	0
CLEC4E	26253	broad.mit.edu	37	12	8689799	8689799	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:8689799G>C	ENST00000299663.3	-	4	449	c.284C>G	c.(283-285)tCt>tGt	p.S95C	CLEC4E_ENST00000446457.2_Intron|CLEC4E_ENST00000545274.1_Intron	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	95	C-type lectin.					integral to membrane	sugar binding	p.S95Y(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					GGTGTCAGTAGAAAAGAAGTA	0.468000													14	37					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29274592	29274592	+	Silent	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:29274592C>G	ENST00000377160.2	+	1	190	c.126C>G	c.(124-126)ctC>ctG	p.L42L		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	42					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L42L(1)		endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						GCAACCTCCTCATTATCACCA	0.458000													21	66					0	0	1	0	0
TMEM260	54916	broad.mit.edu	37	14	57072403	57072403	+	Splice_Site	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:57072403T>C	ENST00000261556.6	+	5	758		c.e5+2		TMEM260_ENST00000536419.1_Splice_Site|TMEM260_ENST00000538838.1_Splice_Site	NM_017799.3	NP_060269.3			transmembrane protein 260																		AAAAAGAAGGTACGTTTTTGA	0.289000													15	54					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5968294	5968294	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:5968294C>A	ENST00000399933.3	-	3	1936	c.1937G>T	c.(1936-1938)gGa>gTa	p.G646V	KIAA2026_ENST00000381461.2_Missense_Mutation_p.G646V	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	646										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		ACTGTGACTTCCATTTACATG	0.343000													12	37					3.07112e-06	3.39309e-06	1	1	0
AP5Z1	9907	broad.mit.edu	37	7	4825973	4825973	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:4825973G>A	ENST00000348624.4	+	10	1319	c.1225G>A	c.(1225-1227)Gaa>Aaa	p.E409K	AP5Z1_ENST00000401897.1_Missense_Mutation_p.E409K	NM_014855.2	NP_055670.1	O43299	K0415_HUMAN	adaptor-related protein complex 5, zeta 1 subunit	409					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										GCTGGCCTTTGAATTCATCCA	0.567000													30	103					0	0	1	0	0
GPR6	2830	broad.mit.edu	37	6	110301379	110301379	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:110301379G>A	ENST00000414000.2	+	3	1348	c.1109G>A	c.(1108-1110)cGt>cAt	p.R370H	GPR6_ENST00000275169.3_Missense_Mutation_p.R355H			P46095	GPR6_HUMAN	G protein-coupled receptor 6	355						integral to plasma membrane				breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		GTGCCCTTTCGTTCCAGGTCT	0.592000													10	78					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117099573	117099573	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:117099573C>T	ENST00000307564.4	-	22	4242	c.4081G>A	c.(4081-4083)Gca>Aca	p.A1361T	AKNA_ENST00000223791.3_Missense_Mutation_p.A821T|AKNA_ENST00000374079.4_Missense_Mutation_p.A306T|AKNA_ENST00000492875.1_5'UTR|AKNA_ENST00000374075.5_Missense_Mutation_p.A1280T|AKNA_ENST00000374088.3_Missense_Mutation_p.A1361T	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GTAGGTCCTGCAGGCGCATAG	0.652000													18	37					0	0	1	0	0
ZNF808	388558	broad.mit.edu	37	19	53058407	53058407	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:53058407G>C	ENST00000359798.4	+	5	2418	c.2238G>C	c.(2236-2238)caG>caC	p.Q746H		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	746					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CGTTCAGTCAGAAGGCAACCC	0.458000													28	141					0	0	1	0	0
ZNF324	25799	broad.mit.edu	37	19	58982420	58982420	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:58982420G>A	ENST00000536459.2	+	4	1270	c.561G>A	c.(559-561)agG>agA	p.R187R	ZNF324_ENST00000535298.1_5'UTR|ZNF324_ENST00000196482.3_Silent_p.R187R			O75467	Z324A_HUMAN	zinc finger protein 324	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TGCTGGGGAGGCAGCCCAGGA	0.667000													3	17					0	0	1	0	0
SWI5	375757	broad.mit.edu	37	9	131038546	131038546	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:131038546C>T	ENST00000320188.5	+	1	122	c.122C>T	c.(121-123)tCt>tTt	p.S41F	SWI5_ENST00000418976.1_5'UTR|SWI5_ENST00000495313.1_Intron|SWI5_ENST00000608796.1_5'UTR|SWI5_ENST00000419867.2_5'UTR	NM_001040011.1	NP_001035100.1	Q1ZZU3	SWI5_HUMAN	SWI5 recombination repair homolog (yeast)						double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding										GCGCAGCTTTCTGTGCGCCAG	0.677000													11	16					0	0	1	0	0
GALNT9	50614	broad.mit.edu	37	12	132688236	132688236	+	Splice_Site	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:132688236C>A	ENST00000328957.8	-	7	1077		c.e7-1		GALNT9_ENST00000535228.1_Splice_Site|GALNT9_ENST00000397325.2_Splice_Site|GALNT9_ENST00000541995.1_Splice_Site	NM_001122636.1	NP_001116108.1	Q9HCQ5	GALT9_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)						protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(1)|large_intestine(2)|lung(5)	9	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)		ACTGCCACACCTGCGGGGAGA	0.687000													4	36					0.000602214	0.000633666	1	1	0
BRCA1	672	broad.mit.edu	37	17	41245549	41245549	+	Nonsense_Mutation	SNP	G	G	A	rs80356889		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:41245549G>A	ENST00000309486.4	-	9	2138	c.1111C>T	c.(1111-1113)Caa>Taa	p.Q371*	BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000493795.1_Nonsense_Mutation_p.Q620*|BRCA1_ENST00000357654.3_Nonsense_Mutation_p.Q667*|BRCA1_ENST00000491747.2_Intron|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000471181.2_Nonsense_Mutation_p.Q667*|BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000346315.3_Nonsense_Mutation_p.Q667*|BRCA1_ENST00000354071.3_Nonsense_Mutation_p.Q667*	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	667					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCCATGAGTTGTAGGTTTCTG	0.398000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			17	64					0	0	1	0	0
SDHB	6390	broad.mit.edu	37	1	17349116	17349116	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:17349116C>A	ENST00000375499.3	-	7	902	c.752G>T	c.(751-753)aGg>aTg	p.R251M		NM_003000.2	NP_002991.2	P21912	DHSB_HUMAN	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	251					respiratory electron transport chain|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	2 iron, 2 sulfur cluster binding|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|protein binding|succinate dehydrogenase (ubiquinone) activity|ubiquinone binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)	10		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0049)|COAD - Colon adenocarcinoma(227;1.18e-05)|BRCA - Breast invasive adenocarcinoma(304;2.41e-05)|Kidney(64;0.000188)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)	Succinic acid(DB00139)	AGGACAGGTCCTTGTGCAGTT	0.552000			"""Mis, N, F"""			"""paraganglioma, pheochromocytoma"""			Familial Paragangliomas;Cowden syndrome;Carney-Stratakis syndrome				25	78					3.65163e-15	4.32015e-15	1	1	0
LRMP	4033	broad.mit.edu	37	12	25249925	25249925	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:25249925C>T	ENST00000354454.3	+	14	1517	c.688C>T	c.(688-690)Cag>Tag	p.Q230*	LRMP_ENST00000548766.1_Nonsense_Mutation_p.Q230*|RP11-713N11.4_ENST00000555862.1_RNA|LRMP_ENST00000547044.1_Nonsense_Mutation_p.Q230*	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	286					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					GTTTCTTAGCCAGTGTGCAGC	0.408000													5	115					0	0	1	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88967719	88967719	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:88967719G>T	ENST00000375961.2	-	2	610	c.396C>A	c.(394-396)tcC>tcA	p.S132S	ZCCHC6_ENST00000375963.3_Silent_p.S132S|ZCCHC6_ENST00000375960.2_Silent_p.S132S|ZCCHC6_ENST00000277141.6_5'UTR			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	132					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						TTTCTTGAAAGGAGTCTTTTC	0.408000													4	174					0.014758	0.0150884	1	1	0
MUC4	4585	broad.mit.edu	37	3	195516804	195516804	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:195516804G>T	ENST00000463781.3	-	2	2106	c.1647C>A	c.(1645-1647)tcC>tcA	p.S549S	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.S549S	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	554					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGCTGTGGGAGGAGTATGTGG	0.552000													25	203					2.90539e-05	3.15904e-05	1	1	0
AHCYL2	23382	broad.mit.edu	37	7	129028913	129028913	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:129028913T>C	ENST00000325006.3	+	3	546	c.492T>C	c.(490-492)gaT>gaC	p.D164D	AHCYL2_ENST00000490911.1_Silent_p.D61D|AHCYL2_ENST00000472554.1_3'UTR|AHCYL2_ENST00000446212.1_Silent_p.D62D|AHCYL2_ENST00000446544.2_Silent_p.D163D|AHCYL2_ENST00000474594.1_Silent_p.D61D|AHCYL2_ENST00000531335.2_Silent_p.D83D	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	164					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						CATATACAGATAGCTCTGATG	0.418000													13	58					0	0	1	0	0
BRD3	8019	broad.mit.edu	37	9	136918507	136918507	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:136918507C>T	ENST00000303407.7	-	2	278	c.93G>A	c.(91-93)aaG>aaA	p.K31K	BRD3_ENST00000357885.2_Silent_p.K31K|BRD3_ENST00000371834.2_Silent_p.K31K	NM_007371.3	NP_031397.1	Q15059	BRD3_HUMAN	bromodomain containing 3	31						nucleus	protein binding		BRD3/C15orf55(3)	kidney(1)|skin(1)|stomach(4)	6				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		TGCGGCCGGGCTTGCTGGGGT	0.682000			T	C15orf55	lethal midline carcinoma of young people								18	29					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83344295	83344295	+	Silent	SNP	G	G	A	rs138430783		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:83344295G>A	ENST00000398309.2	-	14	2054	c.1584C>T	c.(1582-1584)tcC>tcT	p.S528S	DLG2_ENST00000537455.1_Silent_p.S282S|DLG2_ENST00000376104.2_Silent_p.S633S|DLG2_ENST00000398304.1_Silent_p.S10S|DLG2_ENST00000376106.3_Silent_p.S10S|DLG2_ENST00000543673.1_Silent_p.S633S|DLG2_ENST00000530800.1_Silent_p.S37S|DLG2_ENST00000531015.1_Silent_p.S495S|DLG2_ENST00000418306.2_Silent_p.S425S|DLG2_ENST00000532653.1_Silent_p.S528S|DLG2_ENST00000426717.2_Silent_p.S10S|DLG2_ENST00000524982.1_Silent_p.S528S|DLG2_ENST00000280241.8_Silent_p.S567S|DLG2_ENST00000404783.3_Silent_p.S10S|DLG2_ENST00000330014.6_Silent_p.S467S	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	528						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GCAGGGATCCGGACCCGGAGC	0.463000													6	42					0	0	1	0	0
MEIS2	4212	broad.mit.edu	37	15	37184639	37184639	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:37184639T>C	ENST00000338564.5	-	13	1594	c.1148A>G	c.(1147-1149)gAc>gGc	p.D383G	MEIS2_ENST00000424352.2_3'UTR|MEIS2_ENST00000219869.9_3'UTR|MEIS2_ENST00000382766.2_Missense_Mutation_p.D383G|MEIS2_ENST00000397624.3_3'UTR|MEIS2_ENST00000559085.1_3'UTR|MEIS2_ENST00000557796.2_3'UTR|MEIS2_ENST00000340545.5_3'UTR|MEIS2_ENST00000561208.1_Missense_Mutation_p.D390G|MEIS2_ENST00000444725.1_3'UTR|MEIS2_ENST00000397620.2_3'UTR	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	390					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		AGAAACGTAGTCCCCTGGCAT	0.448000													12	147					0	0	1	0	0
C3orf36	80111	broad.mit.edu	37	3	133647234	133647234	+	Silent	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:133647234G>C	ENST00000408895.2	-	1	1422	c.414C>G	c.(412-414)ctC>ctG	p.L138L		NM_025041.2	NP_079317.2	Q3SXR2	CC036_HUMAN	chromosome 3 open reading frame 36	138										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	6						CAGATGAGAAGAGAGAGAAGG	0.567000													7	43					0	0	1	0	0
TFAP2C	7022	broad.mit.edu	37	20	55209228	55209228	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:55209228C>T	ENST00000201031.2	+	5	1069	c.826C>T	c.(826-828)Cgg>Tgg	p.R276W	TFAP2C_ENST00000544508.1_Missense_Mutation_p.R107W	NM_003222.3	NP_003213.1	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	276					cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			Colorectal(105;0.229)			AAATGGAGGCCGGTCCTTGCG	0.448000													17	53					0	0	1	0	0
PCNXL4	64430	broad.mit.edu	37	14	60581890	60581890	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:60581890C>T	ENST00000406854.1	+	4	1622	c.1068C>T	c.(1066-1068)tgC>tgT	p.C356C	PCNXL4_ENST00000406949.1_Silent_p.C122C|PCNXL4_ENST00000404681.2_Silent_p.C356C|PCNXL4_ENST00000317623.4_Silent_p.C122C					pecanex-like 4 (Drosophila)																		GGAAGGAATGCCTTTTCTACA	0.383000													14	83					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194182907	194182907	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:194182907C>T	ENST00000439040.1	-	3	804	c.13G>A	c.(13-15)Gaa>Aaa	p.E5K	ATP13A3_ENST00000256031.4_Missense_Mutation_p.E5K			Q9H7F0	AT133_HUMAN	ATPase type 13A3	5					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		GTCTTCCTTTCTTCCCTGTCC	0.398000													22	51					0	0	1	0	0
NOP58	51602	broad.mit.edu	37	2	203160400	203160400	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:203160400C>T	ENST00000264279.5	+	10	1137	c.911C>T	c.(910-912)tCt>tTt	p.S304F		NM_015934.3	NP_057018.1	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein	304	Nop.				cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(4)|prostate(2)	16						TTTGTAGGTTCTCTTTTAAAT	0.388000													17	100					0	0	1	0	0
SMC2	10592	broad.mit.edu	37	9	106887295	106887295	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:106887295G>A	ENST00000286398.7	+	18	2648	c.2360G>A	c.(2359-2361)aGa>aAa	p.R787K	SMC2_ENST00000374787.3_Missense_Mutation_p.R787K|SMC2_ENST00000303219.8_Missense_Mutation_p.R787K|SMC2_ENST00000374793.3_Missense_Mutation_p.R787K	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	787					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						GAAGCTGAAAGAGAGCGAGAA	0.338000													12	77					0	0	1	0	0
RAPH1	65059	broad.mit.edu	37	2	204304414	204304414	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:204304414C>T	ENST00000319170.5	-	14	3798	c.3499G>A	c.(3499-3501)Gct>Act	p.A1167T	RAPH1_ENST00000374493.3_Missense_Mutation_p.A1219T|RAPH1_ENST00000457812.1_Intron|ABI2_ENST00000295851.5_3'UTR	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	1167					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TTGAGGTCAGCCAGGAATCCA	0.547000													7	68					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106075602	106075602	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:106075602C>G	ENST00000278071.2	-	3	660	c.208G>C	c.(208-210)Gag>Cag	p.E70Q	ITPRIP_ENST00000358187.2_Missense_Mutation_p.E70Q|ITPRIP_ENST00000337478.1_Missense_Mutation_p.E70Q	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	70						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						GCCACCTGCTCCAGTGCCTCC	0.642000													10	67					0	0	1	0	0
SCGB1D1	10648	broad.mit.edu	37	11	61959661	61959661	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:61959661G>C	ENST00000306238.3	+	2	258	c.189G>C	c.(187-189)aaG>aaC	p.K63N		NM_006552.1	NP_006543.1	O95968	SG1D1_HUMAN	secretoglobin, family 1D, member 1	63						extracellular space	binding			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|stomach(1)	9						TGGAAGTGAAGAAATGCGTGG	0.433000													8	71					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45804756	45804756	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:45804756G>T	ENST00000357450.4	-	2	132	c.133C>A	c.(133-135)Ctt>Att	p.L45I	SMC1B_ENST00000404354.3_Missense_Mutation_p.L45I	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	45					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		ACAAAACTAAGTGCATCCATT	0.338000													5	94					0.000602214	0.000633666	1	1	0
PRDM12	59335	broad.mit.edu	37	9	133542071	133542071	+	Silent	SNP	C	C	T	rs143960255		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:133542071C>T	ENST00000253008.2	+	2	360	c.300C>T	c.(298-300)ctC>ctT	p.L100L		NM_021619.2	NP_067632.2	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	100	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GCGAGGGCCTCGGCATCTTCT	0.642000													8	73					0	0	1	0	0
UHRF1	29128	broad.mit.edu	37	19	4950909	4950909	+	RNA	SNP	T	T	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:4950909T>G	ENST00000592666.1	+	0	2295							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		AGTCCGGGTTTCTCGTGTGGC	0.637000													21	54					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79973272	79973272	+	Splice_Site	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:79973272G>T	ENST00000360280.3	+	57	8213		c.e57-1		VPS13A_ENST00000357409.5_Splice_Site|VPS13A_ENST00000376634.4_Splice_Site|VPS13A_ENST00000376636.3_Splice_Site	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)						Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TATTTTCTTAGATCCAAAATC	0.328000													6	38					0.00116845	0.0012201	1	1	0
IFT140	9742	broad.mit.edu	37	16	1630804	1630804	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:1630804C>T	ENST00000426508.2	-	13	1843	c.1480G>A	c.(1480-1482)Gtt>Att	p.V494I	IFT140_ENST00000439987.2_5'UTR|LA16c-395F10.2_ENST00000563162.1_RNA	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	494										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				ACCGTGTAAACGTTTTCTTCA	0.498000													6	41					0	0	1	0	0
IGSF3	3321	broad.mit.edu	37	1	117120153	117120153	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:117120153G>A	ENST00000369486.3	-	11	4131	c.3366C>T	c.(3364-3366)aaC>aaT	p.N1122N	IGSF3_ENST00000318837.6_Silent_p.N1142N|IGSF3_ENST00000369483.1_Silent_p.N1142N	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	1122						integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		AGAGTGCGTCGTTGGAGCAGA	0.488000													8	28					0	0	1	0	0
MED23	9439	broad.mit.edu	37	6	131925327	131925327	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:131925327C>A	ENST00000403834.3	-	15	1938	c.1765G>T	c.(1765-1767)Gga>Tga	p.G589*	MED23_ENST00000368060.3_Nonsense_Mutation_p.G583*|MED23_ENST00000368058.1_Nonsense_Mutation_p.G589*|MED23_ENST00000539158.1_Intron|MED23_ENST00000545957.1_Nonsense_Mutation_p.G224*|MED23_ENST00000540546.1_Nonsense_Mutation_p.G589*|MED23_ENST00000368068.3_Nonsense_Mutation_p.G583*|MED23_ENST00000354577.4_Nonsense_Mutation_p.G589*|MED23_ENST00000368053.4_Nonsense_Mutation_p.G589*			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	583					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		CTGATAAATCCTTTGATGCCC	0.413000													8	60					1.12685e-05	1.23701e-05	1	1	0
CAMTA1	23261	broad.mit.edu	37	1	7811401	7811401	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:7811401G>A	ENST00000303635.7	+	20	5039	c.4832G>A	c.(4831-4833)gGc>gAc	p.G1611D	CAMTA1_ENST00000439411.2_Missense_Mutation_p.G1597D|CAMTA1_ENST00000476864.1_Missense_Mutation_p.G175D	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1611	IQ 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AAGAAATGTGGCAAAAGACGG	0.483000			T	WWTR1	epitheliod hemangioendothelioma								4	118					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57760814	57760814	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:57760814G>A	ENST00000269122.3	+	26	4382	c.4108G>A	c.(4108-4110)Gaa>Aaa	p.E1370K	CLTC_ENST00000393043.1_Missense_Mutation_p.E1370K|CLTC_ENST00000579456.1_Missense_Mutation_p.E307K	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	1370	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CAAGTATGAAGAATATGATAA	0.373000			T	"""ALK, TFE3"""	"""ALCL, renal """								4	30					0	0	1	0	0
EPS8	2059	broad.mit.edu	37	12	15800125	15800125	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:15800125A>T	ENST00000281172.5	-	15	1940	c.1504T>A	c.(1504-1506)Tcc>Acc	p.S502T	EPS8_ENST00000543612.1_Missense_Mutation_p.S502T|EPS8_ENST00000543523.1_Missense_Mutation_p.S502T|EPS8_ENST00000540613.1_Missense_Mutation_p.S242T|EPS8_ENST00000542903.1_Missense_Mutation_p.S242T	NM_004447.5	NP_004438.3	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway substrate 8	502					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		TCCAGGTGGGATCCTCTTGTG	0.453000													13	56					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73240177	73240177	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:73240177C>T	ENST00000377110.3	-	13	1946	c.1703G>A	c.(1702-1704)gGg>gAg	p.G568E	TRPM3_ENST00000358082.3_Missense_Mutation_p.G440E|TRPM3_ENST00000396292.4_Missense_Mutation_p.G440E|TRPM3_ENST00000423814.3_Missense_Mutation_p.G595E|TRPM3_ENST00000357533.2_Missense_Mutation_p.G582E|TRPM3_ENST00000377105.1_Missense_Mutation_p.G427E|TRPM3_ENST00000396280.5_Missense_Mutation_p.G427E|TRPM3_ENST00000408909.2_Missense_Mutation_p.G427E|TRPM3_ENST00000377106.1_Missense_Mutation_p.G440E|TRPM3_ENST00000396285.1_Missense_Mutation_p.G415E|TRPM3_ENST00000377111.2_Missense_Mutation_p.G568E|TRPM3_ENST00000360823.2_Missense_Mutation_p.G440E			Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3							integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GCGATAAGCCCCGCCCATCAG	0.572000													6	27					0	0	1	0	0
WNT9A	7483	broad.mit.edu	37	1	228111878	228111878	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:228111878T>C	ENST00000272164.5	-	3	586	c.576A>G	c.(574-576)cgA>cgG	p.R192R		NM_003395.2	NP_003386.1	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family, member 9A	192					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Prostate(94;0.0405)				CCACACGGGCTCGCAGATCCT	0.617000													4	75					0	0	1	0	0
ATP2C1	27032	broad.mit.edu	37	3	130718463	130718463	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:130718463G>T	ENST00000510168.1	+	27	3139	c.2589G>T	c.(2587-2589)ccG>ccT	p.P863P	ATP2C1_ENST00000508532.1_Silent_p.P863P|ATP2C1_ENST00000507488.2_Silent_p.P847P|ATP2C1_ENST00000504948.1_Silent_p.P847P|ATP2C1_ENST00000422190.2_Silent_p.P863P|ATP2C1_ENST00000505330.1_Silent_p.P847P|ATP2C1_ENST00000359644.3_Silent_p.P863P|ATP2C1_ENST00000504381.1_Silent_p.P808P|ATP2C1_ENST00000428331.2_Silent_p.P863P|ATP2C1_ENST00000533801.2_Silent_p.P858P|ATP2C1_ENST00000328560.8_Silent_p.P863P|ATP2C1_ENST00000513801.1_Silent_p.P847P|ATP2C1_ENST00000393221.4_Silent_p.P897P			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	863					actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	ACTTTCCTCCGCTTCAGAAGG	0.348000									Hailey-Hailey disease				8	65					5.18039e-06	5.70509e-06	1	1	0
SMARCA1	6594	broad.mit.edu	37	X	128622975	128622975	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:128622975G>C	ENST00000371122.4	-	16	2165	c.2036C>G	c.(2035-2037)tCt>tGt	p.S679C	SMARCA1_ENST00000371121.3_Missense_Mutation_p.S667C|SMARCA1_ENST00000371123.1_Missense_Mutation_p.S667C	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	679					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						ACTCTCTTTAGAAGCAAAAAC	0.363000													3	27					0	0	1	0	0
GNPTG	84572	broad.mit.edu	37	16	1411766	1411766	+	Silent	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:1411766C>G	ENST00000204679.4	+	4	244	c.201C>G	c.(199-201)ctC>ctG	p.L67L		NM_032520.4	NP_115909.1	Q9UJJ9	GNPTG_HUMAN	N-acetylglucosamine-1-phosphate transferase, gamma subunit	67						extracellular region|Golgi apparatus	protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	7		Hepatocellular(780;0.0893)				TCTTCCGACTCTCGGGCAAGT	0.607000													3	33					0	0	1	0	0
ARHGEF1	9138	broad.mit.edu	37	19	42392170	42392170	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:42392170G>A	ENST00000599846.1	+	2	142	c.17G>A	c.(16-18)cGa>cAa	p.R6Q	ARHGEF1_ENST00000378152.4_Missense_Mutation_p.R21Q|ARHGEF1_ENST00000337665.4_Missense_Mutation_p.R21Q|ARHGEF1_ENST00000354532.3_Missense_Mutation_p.R6Q|ARHGEF1_ENST00000347545.4_Missense_Mutation_p.R6Q|ARHGEF1_ENST00000596957.1_Intron			Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor (GEF) 1	6					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		GACTTCGCCCGAGGGGCGGTG	0.657000													6	30					0	0	1	0	0
SLC7A9	11136	broad.mit.edu	37	19	33355033	33355033	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:33355033G>C	ENST00000023064.4	-	4	638	c.447C>G	c.(445-447)atC>atG	p.I149M	SLC7A9_ENST00000590341.1_Missense_Mutation_p.I149M|SLC7A9_ENST00000587772.1_Missense_Mutation_p.I149M	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	149					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	ATTTCACAACGATTTGAGGAG	0.597000													8	35					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087408	47087408	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:47087408C>T	ENST00000374312.1	+	3	1044	c.625C>T	c.(625-627)Cac>Tac	p.H209Y	NPY4R_ENST00000395716.1_Missense_Mutation_p.H209Y	NM_005972.4	NP_005963.4			neuropeptide Y receptor Y4																		GCCACTGGCTCACCACCGCAC	0.582000													4	142					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42470513	42470513	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:42470513C>A	ENST00000318006.5	-	10	1025	c.863G>T	c.(862-864)aGc>aTc	p.S288I	VPS39_ENST00000348544.4_Missense_Mutation_p.S299I	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	299	CNH.				protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		AAAATGATTGCTGGCCACATA	0.433000													14	55					1.49906e-05	1.64034e-05	1	1	0
ZNF611	81856	broad.mit.edu	37	19	53210069	53210069	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:53210069C>T	ENST00000543227.1	-	6	513	c.239G>A	c.(238-240)gGc>gAc	p.G80D	ZNF611_ENST00000453741.2_Missense_Mutation_p.G11D|ZNF611_ENST00000600943.1_Silent_p.R62R|ZNF611_ENST00000602162.1_Missense_Mutation_p.G11D|ZNF611_ENST00000319783.1_Missense_Mutation_p.G80D|ZNF611_ENST00000595798.1_Missense_Mutation_p.G11D|ZNF611_ENST00000540744.1_Missense_Mutation_p.G80D|ZNF611_ENST00000596702.1_3'UTR	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	80	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TTCTGTATTGCCTTGCCCTGT	0.363000													11	211					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43314959	43314959	+	Missense_Mutation	SNP	C	C	T	rs138651184	byFrequency	TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:43314959C>T	ENST00000331495.3	+	9	1183	c.847C>T	c.(847-849)Cgg>Tgg	p.R283W	FMNL1_ENST00000592006.1_3'UTR|FMNL1_ENST00000328118.3_Missense_Mutation_p.R283W	NM_005892.3	NP_005883	O95466	FMNL_HUMAN	formin-like 1	283	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						GTGCTTGGTGCGGGGAGGACA	0.587000													27	118					0	0	1	0	0
TRAV38-1	28644	broad.mit.edu	37	14	22739860	22739860	+	RNA	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:22739860C>T	ENST00000390464.2	+	0	10																											CAGCATGACACGAGTTAGCTT	0.512000													7	36					0	0	1	0	0
SSTR1	6751	broad.mit.edu	37	14	38679306	38679306	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:38679306G>A	ENST00000267377.2	+	3	1329	c.712G>A	c.(712-714)Gct>Act	p.A238T		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	238					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GCCCGTGGGGGCTATCTGCCT	0.607000													4	35					0	0	1	0	0
TMEM119	338773	broad.mit.edu	37	12	108985879	108985879	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:108985879T>A	ENST00000392806.3	-	2	449	c.281A>T	c.(280-282)tAc>tTc	p.Y94F		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	94						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						CAGCATCACGTACTGGCGGAA	0.622000													9	43					0	0	1	0	0
RNF216	54476	broad.mit.edu	37	7	5780604	5780604	+	Splice_Site	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:5780604C>A	ENST00000425013.2	-	4	1097	c.873G>T	c.(871-873)acG>acT	p.T291T	RNF216_ENST00000389902.3_Splice_Site_p.T348T	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	291					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TAAAACTTACCGTTTCTTTCA	0.343000													11	64					1.08611e-07	1.23176e-07	1	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971018	21971018	+	Missense_Mutation	SNP	G	G	T	rs104894104		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:21971018G>T	ENST00000579755.1	-	2	675	c.383C>A	c.(382-384)gCc>gAc	p.A128D	CDKN2A_ENST00000304494.5_Missense_Mutation_p.P114T|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000497750.1_Missense_Mutation_p.P63T|CDKN2A_ENST00000530628.2_Missense_Mutation_p.A128D|CDKN2A_ENST00000578845.2_Missense_Mutation_p.P63T|CDKN2A_ENST00000498628.2_Missense_Mutation_p.P63T|CDKN2A_ENST00000579122.1_Missense_Mutation_p.P114T|CDKN2A_ENST00000446177.1_Missense_Mutation_p.P114T|CDKN2A_ENST00000361570.3_Missense_Mutation_p.A169D|CDKN2A_ENST00000498124.1_Missense_Mutation_p.P114T|CDKN2A_ENST00000494262.1_Missense_Mutation_p.P63T|CDKN2A_ENST00000479692.2_Missense_Mutation_p.P63T			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	0					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.P114S(2)|p.H83fs*2(2)|p.0(1)|p.A68fs*3(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		AGGTCCACGGGCAGACGGCCC	0.726000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			7	17					3.09899e-07	3.46298e-07	1	1	0
ROS1	6098	broad.mit.edu	37	6	117645493	117645493	+	Splice_Site	SNP	A	A	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:117645493A>C	ENST00000368508.3	-	34	5840		c.e34+1		GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Splice_Site	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase						transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TATTATACTTACCAAAGGTCA	0.284000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								3	57					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	41988466	41988466	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:41988466G>C	ENST00000219905.7	+	3	1439	c.1258G>C	c.(1258-1260)Gat>Cat	p.D420H	MGA_ENST00000570161.1_Missense_Mutation_p.D420H|MGA_ENST00000568630.1_3'UTR|MGA_ENST00000545763.1_Missense_Mutation_p.D420H|MGA_ENST00000389936.4_Missense_Mutation_p.D420H|MGA_ENST00000566586.1_Missense_Mutation_p.D420H	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	420						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CAGTGATGATGATCCTATACT	0.438000													13	48					0	0	1	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49377381	49377381	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:49377381C>A	ENST00000200453.5	+	2	1160	c.891C>A	c.(889-891)ccC>ccA	p.P297P		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	297	Glu-rich.			P -> L (in Ref. 2; CAG33540).	apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		CCCAGAGGCCCCAGCTCAAGT	0.602000													9	36					0.0477658	0.0482589	1	1	0
ETV3L	440695	broad.mit.edu	37	1	157068581	157068581	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:157068581G>A	ENST00000454449.2	-	3	687	c.403C>T	c.(403-405)Cgg>Tgg	p.R135W		NM_001004341.2	NP_001004341.1	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	135						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Hepatocellular(266;0.158)	Prostate(1639;0.184)				GGCGGCGCCCGCACTTCCCAC	0.577000													16	69					0	0	1	0	0
C6orf118	168090	broad.mit.edu	37	6	165703464	165703464	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:165703464C>G	ENST00000230301.8	-	7	1233	c.1213G>C	c.(1213-1215)Gag>Cag	p.E405Q	C6orf118_ENST00000494696.2_5'UTR|C6orf118_ENST00000543069.1_3'UTR	NM_144980.3	NP_659417.2	Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	405										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		GCTTGTATCTCATCCCACTTA	0.343000													18	103					0	0	1	0	0
RBP1	5947	broad.mit.edu	37	3	139257789	139257789	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:139257789G>A	ENST00000483943.2	-	2	272	c.272C>T	c.(271-273)gCc>gTc	p.A91V	RP11-319G6.1_ENST00000515247.1_RNA|RBP1_ENST00000492918.1_Missense_Mutation_p.A91V|RBP1_ENST00000232219.2_Missense_Mutation_p.A91V	NM_001130993.1	NP_001124465.1	P09455	RET1_HUMAN	retinol binding protein 1, cellular	29						cytoplasm	retinal binding|retinol binding|transporter activity			endometrium(1)|large_intestine(2)|lung(1)|prostate(1)	5					Vitamin A(DB00162)	TTTGCGCAAGGCCACATTGAC	0.562000													5	94					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	160994700	160994700	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:160994700G>C	ENST00000283249.2	-	9	1355	c.1118C>G	c.(1117-1119)tCt>tGt	p.S373C	ITGB6_ENST00000428609.2_Missense_Mutation_p.S331C|ITGB6_ENST00000409872.1_Missense_Mutation_p.S373C|ITGB6_ENST00000409967.2_Missense_Mutation_p.S373C	NM_001282353.1|NM_001282354.1|NM_001282388.1	NP_001269282.1|NP_001269283.1|NP_001269317.1	P18564	ITB6_HUMAN	integrin, beta 6	373					cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						TTCCACCTCAGACCGCAGTTC	0.413000													12	78					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48956349	48956349	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:48956349T>C	ENST00000294954.7	-	3	272	c.251A>G	c.(250-252)gAt>gGt	p.D84G	LHCGR_ENST00000405626.1_Missense_Mutation_p.D84G|LHCGR_ENST00000401907.1_Missense_Mutation_p.D84G|LHCGR_ENST00000344775.3_Missense_Mutation_p.D84G|LHCGR_ENST00000403273.1_Missense_Mutation_p.D84G|STON1-GTF2A1L_ENST00000402114.2_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	84					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	TTCCAGGGAATCAATCTGAGA	0.408000													15	90					0	0	1	0	0
CHRM4	1132	broad.mit.edu	37	11	46407253	46407253	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:46407253G>A	ENST00000433765.2	-	1	854	c.855C>T	c.(853-855)cgC>cgT	p.R285R		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	285					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	CAGCCACGGGGCGCGGTGGCG	0.687000													5	26					0	0	1	0	0
TEKT3	64518	broad.mit.edu	37	17	15207410	15207410	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:15207410C>A	ENST00000395930.1	-	9	1502	c.1316G>T	c.(1315-1317)aGg>aTg	p.R439M	TEKT3_ENST00000462175.1_5'UTR|TEKT3_ENST00000338696.2_Missense_Mutation_p.R439M	NM_031898.2	NP_114104.1	Q9BXF9	TEKT3_HUMAN	tektin 3	439					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				endometrium(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	23				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		CTCTGCATCCCTCAGGCGCTG	0.532000													8	34					0.000274275	0.00029219	1	1	0
GPR50	9248	broad.mit.edu	37	X	150349125	150349125	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:150349125C>T	ENST00000218316.3	+	2	1139	c.1070C>T	c.(1069-1071)gCt>gTt	p.A357V		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	357	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					GCCTGTCCTGCTGTGGAGGAA	0.622000													12	41					0	0	1	0	0
EHD1	10938	broad.mit.edu	37	11	64645744	64645744	+	Missense_Mutation	SNP	C	C	A	rs3205255		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:64645744C>A	ENST00000320631.3	-	1	447	c.193G>T	c.(193-195)Ggg>Tgg	p.G65W	EHD1_ENST00000359393.2_Missense_Mutation_p.G65W	NM_001282445.1|NM_006795.2	NP_001269374.1|NP_006786.2	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	65					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						CTGTACTGCCCCACGAGGAGC	0.632000													10	58					3.86212e-05	4.15967e-05	1	1	0
CD33	945	broad.mit.edu	37	19	51728762	51728762	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:51728762G>C	ENST00000262262.4	+	2	347	c.326G>C	c.(325-327)aGg>aCg	p.R109T	CD33_ENST00000436584.2_Intron|CD33_ENST00000391796.3_Missense_Mutation_p.R109T|CD33_ENST00000421133.2_Intron	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule	109	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	GTAGACGCCAGGAGGAGGGAT	0.507000													13	66					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187629483	187629483	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:187629483T>C	ENST00000441802.2	-	2	1708	c.1499A>G	c.(1498-1500)tAc>tGc	p.Y500C		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	500	Cadherin 4.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TGCGATACTGTATGTCACGTA	0.493000										HNSCC(5;0.00058)			9	110					0	0	1	0	0
SARS2	54938	broad.mit.edu	37	19	39421124	39421124	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:39421124C>T	ENST00000221431.6	-	1	412	c.253G>A	c.(253-255)Gac>Aac	p.D85N	CTC-360G5.8_ENST00000599996.1_Intron|SARS2_ENST00000448145.2_Intron|SARS2_ENST00000600042.1_Missense_Mutation_p.D85N|SARS2_ENST00000430193.3_Missense_Mutation_p.D85N	NM_017827.3	NP_060297.1	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2, mitochondrial	85					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GCGGGCAGGTCCGCCGAGCGC	0.677000											OREG0025455|OREG0032101	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)|type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	10	46					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	95993712	95993712	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:95993712C>G	ENST00000324765.8	+	3	640	c.293C>G	c.(292-294)tCt>tGt	p.S98C	DIAPH2_ENST00000373054.4_Missense_Mutation_p.S87C|DIAPH2_ENST00000373049.4_Missense_Mutation_p.S98C|DIAPH2_ENST00000355827.4_Missense_Mutation_p.S98C|DIAPH2_ENST00000373061.3_Missense_Mutation_p.S98C			O60879	DIAP2_HUMAN	diaphanous-related formin 2	98	GBD/FH3.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						GATGAACGATCTTTGAATTTG	0.343000													11	35					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134147328	134147328	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:134147328G>A	ENST00000389887.5	+	2	2628	c.132G>A	c.(130-132)gcG>gcA	p.A44A	GLB1L3_ENST00000431683.2_Silent_p.A44A			Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	44					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TTGGAAGAGCGCATCCGTCCC	0.502000													15	111					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47037250	47037250	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:47037250G>A	ENST00000450053.3	+	14	2124	c.1945G>A	c.(1945-1947)Gcc>Acc	p.A649T	NBEAL2_ENST00000292309.5_Missense_Mutation_p.A649T|NBEAL2_ENST00000383740.2_5'UTR	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	649							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CTTCACGGCGGCCGGGACCCT	0.602000													3	34					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138200359	138200359	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:138200359C>G	ENST00000237289.4	+	7	1843	c.1777C>G	c.(1777-1779)Caa>Gaa	p.Q593E		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	593	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)|p.Q593*(1)|p.P587fs*93(1)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		CTGCCTGTCTCAAGCTGCACG	0.607000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								14	60					0	0	1	0	0
GCNT3	9245	broad.mit.edu	37	15	59911493	59911493	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:59911493C>G	ENST00000396065.1	+	3	1504	c.1056C>G	c.(1054-1056)taC>taG	p.Y352*	GCNT3_ENST00000560585.1_Nonsense_Mutation_p.Y352*	NM_004751.2	NP_004742.1	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin type	352					protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ACCCCAAGTACGACATCTCAG	0.537000													20	73					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43934544	43934544	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:43934544C>T	ENST00000282406.4	+	11	1936	c.1826C>T	c.(1825-1827)gCg>gTg	p.A609V		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	609						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CTTTAGAAGGCGACCCAAATA	0.493000													8	88					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30012000	30012000	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:30012000G>A	ENST00000346128.6	-	20	3458	c.2984C>T	c.(2983-2985)tCg>tTg	p.S995L	TJP1_ENST00000356107.6_Missense_Mutation_p.S995L|TJP1_ENST00000545208.2_Intron|TJP1_ENST00000400011.2_Intron	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	995					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		ATCTACATGCGACGACAATGA	0.443000													4	109					0	0	1	0	0
RECQL4	9401	broad.mit.edu	37	8	145737616	145737616	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:145737616G>A	ENST00000428558.2	-	19	3188	c.3147C>T	c.(3145-3147)gaC>gaT	p.D1049D	RECQL4_ENST00000532237.1_5'UTR	NM_004260.3	NP_004251.3	O94761	RECQ4_HUMAN	RecQ protein-like 4	1049					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CACATATCTGGTCCTTCTCCT	0.647000			"""N, F, S"""			"""osteosarcoma, skin basal and sqamous cell"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Rothmund-Thomson syndrome;RAPADILINO syndrome;Baller-Gerold syndrome				5	18					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102134098	102134098	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:102134098T>C	ENST00000369138.1	+	6	1311	c.821T>C	c.(820-822)gTt>gCt	p.V274A	GRIK2_ENST00000358361.3_Missense_Mutation_p.V274A|GRIK2_ENST00000318991.6_Missense_Mutation_p.V274A|GRIK2_ENST00000369137.3_Missense_Mutation_p.V274A|GRIK2_ENST00000369134.4_Missense_Mutation_p.V225A|GRIK2_ENST00000421544.1_Missense_Mutation_p.V274A|GRIK2_ENST00000413795.1_Missense_Mutation_p.V274A	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	274					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TACAGTGGTGTTAACATGACA	0.423000													13	35					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112326054	112326054	+	Silent	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:112326054A>G	ENST00000206423.3	-	7	3428	c.2475T>C	c.(2473-2475)gtT>gtC	p.V825V	CCDC80_ENST00000439685.2_Silent_p.V825V	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	825										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						ACACTCCCCCAACTTCCTCTC	0.363000													7	61					0	0	1	0	0
PSPH	5723	broad.mit.edu	37	7	56079471	56079471	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:56079471C>G	ENST00000395471.3	-	8	1467	c.662G>C	c.(661-663)gGa>gCa	p.G221A	PSPH_ENST00000275605.3_Missense_Mutation_p.G221A|PSPH_ENST00000459834.1_5'UTR			P78330	SERB_HUMAN	phosphoserine phosphatase	221					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(1)|skin(1)	11	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTCCAGTTCTCCCAGCAGCTC	0.388000													5	55					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99514792	99514792	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:99514792G>A	ENST00000261037.3	+	5	2427	c.2047G>A	c.(2047-2049)Gag>Aag	p.E683K	COL8A1_ENST00000273342.4_Missense_Mutation_p.E683K	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	683	C1q.|Nonhelical region (NC1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						CAAGAACAACGAGCCCGTGAT	0.562000													12	42					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30936329	30936329	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:30936329G>A	ENST00000355537.3	+	2	2007	c.1860G>A	c.(1858-1860)ctG>ctA	p.L620L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	620					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AGTATAACCTGCAGGGTCCTG	0.582000													23	133					0	0	1	0	0
PVRL2	5819	broad.mit.edu	37	19	45368628	45368628	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:45368628G>A	ENST00000252483.5	+	2	189	c.189G>A	c.(187-189)ctG>ctA	p.L63L	PVRL2_ENST00000252485.4_Silent_p.L63L	NM_001042724.1	NP_001036189.1	Q92692	PVRL2_HUMAN	poliovirus receptor-related 2 (herpesvirus entry mediator B)	63	Ig-like V-type.				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(6)|lung(5)	13	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		TTCCTGGACTGTACATCTCCC	0.652000													7	28					0	0	1	0	0
RAPGEFL1	51195	broad.mit.edu	37	17	38348913	38348913	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:38348913C>T	ENST00000436615.3	+	12	1584	c.1094C>T	c.(1093-1095)cCt>cTt	p.P365L	RAPGEFL1_ENST00000544503.1_Missense_Mutation_p.P414L|RAPGEFL1_ENST00000264644.6_Missense_Mutation_p.P365L|RAPGEFL1_ENST00000456989.2_Missense_Mutation_p.P420L	NM_016339.3	NP_057423.1	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor (GEF)-like 1	571					G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)	15						ATGAAGCCCCCTGTGATTCCC	0.532000													10	217					0	0	1	0	0
KRTAP10-5	386680	broad.mit.edu	37	21	46000443	46000443	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr21:46000443T>C	ENST00000400372.1	-	1	38	c.13A>G	c.(13-15)Acc>Gcc	p.T5A	TSPEAR_ENST00000323084.4_Intron	NM_198694.2	NP_941967.2	P60370	KR105_HUMAN	keratin associated protein 10-5	5						keratin filament				endometrium(2)|kidney(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	14						ACGGACATGGTGCACGCGGCC	0.652000													8	52					0	0	1	0	0
KCNH3	23416	broad.mit.edu	37	12	49950153	49950153	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:49950153G>A	ENST00000257981.6	+	13	2729	c.2469G>A	c.(2467-2469)agG>agA	p.R823R		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	823					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						GGGTTCACAGGGTAGTAGATG	0.612000													3	57					0	0	1	0	0
NOX4	50507	broad.mit.edu	37	11	89133467	89133467	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:89133467G>A	ENST00000535633.1	-	10	1165	c.855C>T	c.(853-855)gtC>gtT	p.V285V	NOX4_ENST00000413594.2_Silent_p.V330V|NOX4_ENST00000343727.5_Silent_p.V285V|NOX4_ENST00000531342.1_Intron|NOX4_ENST00000424319.1_Silent_p.V285V|NOX4_ENST00000263317.4_Silent_p.V309V|NOX4_ENST00000534731.1_Silent_p.V309V|NOX4_ENST00000375979.3_Intron|NOX4_ENST00000525196.1_Intron|NOX4_ENST00000542487.1_Silent_p.V285V|NOX4_ENST00000527626.1_Silent_p.V143V|NOX4_ENST00000528341.1_Silent_p.V284V|NOX4_ENST00000527956.1_Silent_p.V285V|NOX4_ENST00000532825.1_Silent_p.V285V	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4	309	Ferric oxidoreductase.|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AAATGATGGTGACTGGCTTAT	0.428000													5	80					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	978034	978034	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:978034G>T	ENST00000537687.1	+	9	3785	c.3142G>T	c.(3142-3144)Gaa>Taa	p.E1048*	WNK1_ENST00000574564.1_Nonsense_Mutation_p.E347*|WNK1_ENST00000535572.1_Intron|WNK1_ENST00000315939.6_Intron|WNK1_ENST00000530271.2_Nonsense_Mutation_p.E1133*|WNK1_ENST00000340908.4_Intron	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	806					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			AGGAAGCCCAGAATATTCCAG	0.498000													13	72					2.27111e-07	2.55873e-07	1	1	0
MCPH1	79648	broad.mit.edu	37	8	6302795	6302795	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:6302795G>A	ENST00000344683.5	+	8	1628	c.1552G>A	c.(1552-1554)Gca>Aca	p.A518T	MCPH1_ENST00000522905.1_Missense_Mutation_p.A470T|MCPH1_ENST00000519480.1_Missense_Mutation_p.A518T	NM_024596.3	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin 1	518						microtubule organizing center			AGPAT5/MCPH1(2)	central_nervous_system(1)|large_intestine(4)|skin(1)	6		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		GAAAGAAGACGCATGCCCAGA	0.488000													19	56					0	0	1	0	0
SLC16A7	9194	broad.mit.edu	37	12	60173277	60173277	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:60173277C>T	ENST00000261187.4	+	5	1418	c.1254C>T	c.(1252-1254)agC>agT	p.S418S	SLC16A7_ENST00000552432.1_Silent_p.S418S|SLC16A7_ENST00000547379.1_Silent_p.S418S|SLC16A7_ENST00000543448.1_Silent_p.S319S|SLC16A7_ENST00000552024.1_Silent_p.S418S	NM_004731.4	NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	418						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	TAGCAGCAAGCGTGTGGCTGC	0.413000													3	45					0	0	1	0	0
TMEM39A	55254	broad.mit.edu	37	3	119176954	119176954	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:119176954G>A	ENST00000319172.5	-	3	667	c.247C>T	c.(247-249)Ctg>Ttg	p.L83L	TMEM39A_ENST00000486159.1_5'UTR	NM_018266.1	NP_060736.1	Q9NV64	TM39A_HUMAN	transmembrane protein 39A	83						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	13				GBM - Glioblastoma multiforme(114;0.244)		GCAACCAACAGGTAGATGAAA	0.413000													16	62					0	0	1	0	0
TESK2	10420	broad.mit.edu	37	1	45810775	45810775	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:45810775G>A	ENST00000372086.3	-	11	1853	c.1453C>T	c.(1453-1455)Cgc>Tgc	p.R485C	TESK2_ENST00000486676.1_5'UTR|TESK2_ENST00000372084.1_Missense_Mutation_p.R456C|TESK2_ENST00000538496.1_Missense_Mutation_p.R402C|TESK2_ENST00000341771.6_Missense_Mutation_p.R456C	NM_007170.2	NP_009101.2	Q96S53	TESK2_HUMAN	testis-specific kinase 2	485					actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	32	Acute lymphoblastic leukemia(166;0.155)					CTACTTAGGCGTGGTGGGGGC	0.557000													20	108					0	0	1	0	0
HSD11B1	3290	broad.mit.edu	37	1	209905860	209905860	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:209905860G>A	ENST00000367028.2	+	6	766	c.597G>A	c.(595-597)aaG>aaA	p.K199K	HSD11B1_ENST00000261465.1_Silent_p.K199K|HSD11B1_ENST00000367027.3_Silent_p.K199K	NM_001206741.1	NP_001193670.1	P28845	DHI1_HUMAN	hydroxysteroid (11-beta) dehydrogenase 1	199					glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase|11-beta-hydroxysteroid dehydrogenase (NADP+) activity|binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	16				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	CCATCAGAAAGGAATATTCAG	0.383000													8	143					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134084313	134084313	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:134084313G>T	ENST00000264360.5	+	4	3805	c.2979G>T	c.(2977-2979)caG>caT	p.Q993H		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CAGAAGCCCAGCCTGGGGCAG	0.547000													25	117					2.44723e-14	2.88529e-14	1	1	0
GP2	2813	broad.mit.edu	37	16	20326023	20326023	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:20326023C>T	ENST00000302555.5	-	10	1651	c.1502G>A	c.(1501-1503)gGt>gAt	p.G501D	GP2_ENST00000381360.5_Splice_Site_p.G357D|GP2_ENST00000381362.4_Splice_Site_p.G504D|GP2_ENST00000341642.5_Splice_Site_p.G354D			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	504						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AGACTGTGCACCTGTGAACAA	0.512000													7	30					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215845305	215845305	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:215845305C>T	ENST00000272895.7	-	31	4861	c.4642G>A	c.(4642-4644)Gcc>Acc	p.A1548T	ABCA12_ENST00000389661.4_Missense_Mutation_p.A1230T	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1548	ABC transporter 1.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCCAGGAAGGCGATGCGGTCA	0.512000													11	47					0	0	1	0	0
CA5A	763	broad.mit.edu	37	16	87960473	87960473	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:87960473C>T	ENST00000309893.2	-	2	286	c.221G>A	c.(220-222)aGc>aAc	p.S74N	CA5A_ENST00000568801.1_5'UTR	NM_001739.1	NP_001730.1	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial	74					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding			large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(80;0.0513)		GTCATAGACGCTGTCCCTCCA	0.597000													4	19					0	0	1	0	0
FAM86DP	692099	broad.mit.edu	37	3	75478359	75478359	+	RNA	SNP	G	G	A	rs73842006	by1000genomes	TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:75478359G>A	ENST00000459803.1	-	0	306					NR_024241.1																						CATACAGCTCGTCCAAAGCCT	0.547000													3	17					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67649700	67649700	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:67649700C>T	ENST00000335894.4	+	7	721	c.655C>T	c.(655-657)Cgg>Tgg	p.R219W	IQCH_ENST00000358767.3_Missense_Mutation_p.R46W|IQCH_ENST00000546225.1_5'UTR	NM_001031715.2	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H	219										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		CACTATACCTCGGGAACCACC	0.398000													8	33					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50667018	50667018	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:50667018T>A	ENST00000355832.5	-	21	4403	c.4325A>T	c.(4324-4326)gAt>gTt	p.D1442V	RP11-123B3.2_ENST00000423283.1_RNA|ERCC6_ENST00000542458.1_Missense_Mutation_p.D812V	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	1442					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						GGCCTGGCCATCAGTGTGGGC	0.527000								Direct reversal of damage;Nucleotide excision repair (NER)					13	72					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216017670	216017670	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:216017670C>G	ENST00000366943.2	-	46	9610	c.9224G>C	c.(9223-9225)aGa>aCa	p.R3075T	USH2A_ENST00000307340.3_Missense_Mutation_p.R3075T			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3075	Fibronectin type-III 17.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGACAGGTCTCTCAGAATAAA	0.378000										HNSCC(13;0.011)			9	45					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67680647	67680647	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:67680647G>A	ENST00000334583.6	+	7	825	c.497G>A	c.(496-498)tGt>tAt	p.C166Y	RLTPR_ENST00000545661.1_Missense_Mutation_p.C166Y	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	166										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GAGGCTCTGTGTGACTACAAT	0.552000													5	177					0	0	1	0	0
RHOB	388	broad.mit.edu	37	2	20647415	20647415	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:20647415G>T	ENST00000272233.4	+	1	581	c.189G>T	c.(187-189)caG>caT	p.Q63H		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	63					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		CGGCGGGCCAGGAGGACTACG	0.652000													16	80					1.52009e-12	1.7769e-12	1	1	0
CDH26	60437	broad.mit.edu	37	20	58558037	58558037	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:58558037C>G	ENST00000348616.4	+	5	753	c.453C>G	c.(451-453)ttC>ttG	p.F151L	CDH26_ENST00000244047.5_Missense_Mutation_p.F151L	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	151	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CCTTGATTTTCAACATTAGGA	0.413000													19	112					0	0	1	0	0
MAN2B2	23324	broad.mit.edu	37	4	6621665	6621665	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:6621665G>A	ENST00000285599.3	+	18	2862	c.2826G>A	c.(2824-2826)caG>caA	p.Q942Q	MAN2B2_ENST00000504248.1_Silent_p.Q891Q	NM_015274.1	NP_056089.1	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	942					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	30						CTGTGCTGCAGGCGCTGGGGT	0.657000													7	47					0	0	1	0	0
ITGB7	3695	broad.mit.edu	37	12	53585655	53585655	+	Silent	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:53585655G>C	ENST00000267082.5	-	15	2535	c.2304C>G	c.(2302-2304)ctC>ctG	p.L768L	ITGB7_ENST00000338737.4_Silent_p.L620L|ITGB7_ENST00000422257.3_Silent_p.L768L|ITGB7_ENST00000550743.2_Silent_p.L620L	NM_000889.1	NP_000880.1	P26010	ITB7_HUMAN	integrin, beta 7	768					cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			NS(2)|breast(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GCTTCCAGTTGAGTTGTTGCT	0.592000													3	56					0	0	1	0	0
GALNT3	2591	broad.mit.edu	37	2	166621536	166621536	+	Silent	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:166621536A>G	ENST00000392701.3	-	3	1321	c.546T>C	c.(544-546)ccT>ccC	p.P182P		NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	182					protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						TGGGCAGGGGAGGGCAGCGCT	0.383000													13	44					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204588349	204588349	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:204588349C>A	ENST00000367175.1	-	1	2984	c.772G>T	c.(772-774)Gaa>Taa	p.E258*	LRRN2_ENST00000367176.3_Nonsense_Mutation_p.E258*|LRRN2_ENST00000367177.3_Nonsense_Mutation_p.E258*			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	258					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GGCACCTGTTCCAGTGCCCGC	0.637000													12	40					4.36969e-10	5.03065e-10	1	1	0
PPP1R10	5514	broad.mit.edu	37	6	30570103	30570103	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:30570103C>T	ENST00000376511.2	-	19	2875	c.2323G>A	c.(2323-2325)Ggt>Agt	p.G775S		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	775	Gly-rich.				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						CCCATGCCACCGCCAGGGCCT	0.672000													25	127					0	0	1	0	0
PI16	221476	broad.mit.edu	37	6	36922641	36922641	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:36922641G>C	ENST00000373674.3	+	1	433	c.105G>C	c.(103-105)ttG>ttC	p.L35F		NM_001199159.1|NM_153370.2	NP_001186088.1|NP_699201.2	Q6UXB8	PI16_HUMAN	peptidase inhibitor 16	35						extracellular region|integral to membrane	peptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGAAACGTTTGATGGTGGAGC	0.612000													7	37					0	0	1	0	0
DND1	373863	broad.mit.edu	37	5	140052115	140052115	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:140052115G>A	ENST00000542735.1	-	3	562	c.519C>T	c.(517-519)agC>agT	p.S173S		NM_194249.2	NP_919225.1	Q8IYX4	DND1_HUMAN	DND microRNA-mediated repression inhibitor 1	173	RRM 2.				multicellular organismal development|negative regulation of gene silencing by miRNA	cytoplasm|nucleus	AU-rich element binding|nucleotide binding			central_nervous_system(1)|prostate(4)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGGTCCGGGGCTGGGCAGCA	0.721000													4	7					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48314884	48314884	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:48314884C>G	ENST00000435803.1	+	17	5645	c.5621C>G	c.(5620-5622)tCa>tGa	p.S1874*		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1874					transport	integral to membrane	ATP binding|ATPase activity	p.S1819*(1)|p.S1874*(1)		breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCACCATGTTCAAATGAAAGC	0.423000													5	44					0	0	1	0	0
DDX43	55510	broad.mit.edu	37	6	74116130	74116130	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:74116130G>C	ENST00000370336.4	+	7	1009	c.851G>C	c.(850-852)gGa>gCa	p.G284A	DDX43_ENST00000539829.1_3'UTR	NM_018665.2	NP_061135.2	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	284	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						GATCTTATAGGAGTAGCCCAG	0.423000													13	45					0	0	1	0	0
DAPK3	1613	broad.mit.edu	37	19	3964871	3964871	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:3964871T>C	ENST00000545797.2	-	3	424	c.181A>G	c.(181-183)Atc>Gtc	p.I61V	DAPK3_ENST00000301264.3_Missense_Mutation_p.I61V			O43293	DAPK3_HUMAN	death-associated protein kinase 3	61	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|skin(2)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCGCTCGATCTCCTCCCGG	0.627000													6	56					0	0	1	0	0
TJP2	9414	broad.mit.edu	37	9	71831288	71831288	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:71831288G>A	ENST00000377245.4	+	3	356	c.148G>A	c.(148-150)Gga>Aga	p.G50R	TJP2_ENST00000539225.1_Missense_Mutation_p.G81R|TJP2_ENST00000377259.1_Missense_Mutation_p.G27R|TJP2_ENST00000265384.7_Missense_Mutation_p.G50R|TJP2_ENST00000348208.4_Missense_Mutation_p.G50R|TJP2_ENST00000453658.2_Missense_Mutation_p.G27R|TJP2_ENST00000535702.1_Missense_Mutation_p.G54R	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	50	PDZ 1.				cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						TGCAGTGTCCGGAGGCAGAGA	0.453000													8	50					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150730953	150730953	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:150730953C>A	ENST00000358849.4	+	2	450	c.357C>A	c.(355-357)ctC>ctA	p.L119L	ABCB8_ENST00000493338.1_3'UTR|ABCB8_ENST00000477719.1_Silent_p.L119L|ABCB8_ENST00000477092.1_Silent_p.L119L|ABCB8_ENST00000542328.1_Intron|ABCB8_ENST00000498578.1_Silent_p.L119L|ABCB8_ENST00000356058.4_Silent_p.L156L|ABCB8_ENST00000297504.6_Silent_p.L136L	NM_001282291.1|NM_001282293.1|NM_007188.3	NP_001269220.1|NP_001269222.1|NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	136						ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACTGGAAGCTCTTCTGGCAGT	0.632000													7	49					5.18039e-06	5.70509e-06	1	1	0
VMP1	81671	broad.mit.edu	37	17	57915699	57915699	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:57915699G>C	ENST00000262291.4	+	11	1328	c.1018G>C	c.(1018-1020)Gag>Cag	p.E340Q	VMP1_ENST00000588617.1_3'UTR|VMP1_ENST00000537567.1_Missense_Mutation_p.E206Q|VMP1_ENST00000536180.1_Missense_Mutation_p.E243Q|VMP1_ENST00000539763.1_Missense_Mutation_p.E148Q|VMP1_ENST00000545362.1_Missense_Mutation_p.E284Q	NM_030938.3	NP_112200.2	Q96GC9	VMP1_HUMAN	vacuole membrane protein 1	340					autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|skin(2)	16						GCCATTTCAGGAGTACCTGGA	0.502000													6	47					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160289481	160289481	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:160289481C>A	ENST00000392783.2	-	9	2182	c.1687G>T	c.(1687-1689)Ggg>Tgg	p.G563W	BAZ2B_ENST00000355831.2_Missense_Mutation_p.G563W|BAZ2B_ENST00000343439.5_Missense_Mutation_p.G561W|BAZ2B_ENST00000392782.1_Missense_Mutation_p.G561W	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	563					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.G563R(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						TTTTCCTTCCCTTGACTATGC	0.448000													26	109					3.6726e-16	4.35248e-16	1	1	0
KIAA0825	285600	broad.mit.edu	37	5	93856216	93856216	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:93856216T>A	ENST00000513200.3	-	4	779	c.707A>T	c.(706-708)aAt>aTt	p.N236I	KIAA0825_ENST00000329378.7_Missense_Mutation_p.N236I|KIAA0825_ENST00000312498.7_Missense_Mutation_p.N236I|KIAA0825_ENST00000427991.2_Missense_Mutation_p.N236I	NM_001145678.1	NP_001139150.1	Q8IV33	K0825_HUMAN	KIAA0825	236										breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|pancreas(1)|prostate(1)|skin(1)	13						TACATCTAAATTTGAATCTCT	0.308000													6	48					0	0	1	0	0
UNC93B1	81622	broad.mit.edu	37	11	67766695	67766695	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:67766695G>C	ENST00000227471.2	-	5	714	c.635C>G	c.(634-636)tCc>tGc	p.S212C	UNC93B1_ENST00000530331.1_5'UTR	NM_030930.2	NP_112192.2	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1 (C. elegans)	212					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome											GGGCGCGTGGGAGCCCCGCGG	0.602000													9	56					0	0	1	0	0
MGAT5	4249	broad.mit.edu	37	2	135012105	135012105	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:135012105C>T	ENST00000409645.1	+	2	383	c.131C>T	c.(130-132)tCc>tTc	p.S44F	MGAT5_ENST00000281923.2_Missense_Mutation_p.S44F|MGAT5_ENST00000468758.1_3'UTR			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	44					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		GAAAGCAGCTCCATGCTGCGC	0.517000													4	24					0	0	1	0	0
NF2	4771	broad.mit.edu	37	22	30035145	30035145	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:30035145G>A	ENST00000338641.4	+	3	748	c.307G>A	c.(307-309)Gag>Aag	p.E103K	NF2_ENST00000361166.4_Missense_Mutation_p.E103K|NF2_ENST00000361676.4_Missense_Mutation_p.E61K|NF2_ENST00000403999.3_Missense_Mutation_p.E103K|NF2_ENST00000334961.7_Intron|NF2_ENST00000403435.1_Missense_Mutation_p.E103K|NF2_ENST00000397789.3_Missense_Mutation_p.E103K|NF2_ENST00000361452.4_Intron|NF2_ENST00000353887.4_Intron|NF2_ENST00000413209.2_Missense_Mutation_p.E103K|NF2_ENST00000347330.5_Intron	NM_000268.3|NM_016418.5|NM_181832.2	NP_000259.1|NP_057502.2|NP_861970.1	P35240	MERL_HUMAN	neurofibromin 2 (merlin)	103	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(3)|p.H95fs*3(1)|p.V86_Q111>E(1)|p.L97fs*17(1)		NS(1)|bone(2)|breast(5)|central_nervous_system(21)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(17)|large_intestine(9)|liver(1)|lung(9)|meninges(372)|ovary(2)|pituitary(1)|pleura(9)|prostate(1)|skin(7)|soft_tissue(303)|stomach(2)|thyroid(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	776						ATTTTATCCTGAGAATGCTGA	0.438000			"""D, Mis, N, F, S, O"""		"""meningioma, acoustic neuroma, renal """	"""meningioma, acoustic neuroma"""			Neurofibromatosis, type 2				11	63					0	0	1	0	0
PELI2	57161	broad.mit.edu	37	14	56763459	56763459	+	Missense_Mutation	SNP	G	G	A	rs28504146	byFrequency	TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:56763459G>A	ENST00000267460.4	+	6	1124	c.838G>A	c.(838-840)Gcc>Acc	p.A280T		NM_021255.2	NP_067078.1	Q9HAT8	PELI2_HUMAN	pellino E3 ubiquitin protein ligase family member 2	280					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			kidney(6)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	22						GATTAACGCCGCCCGGCCTCA	0.577000													11	21					0	0	1	0	0
NCK2	8440	broad.mit.edu	37	2	106497939	106497939	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:106497939G>A	ENST00000233154.4	+	4	824	c.382G>A	c.(382-384)Gat>Aat	p.D128N	NCK2_ENST00000522586.1_Intron|NCK2_ENST00000451463.2_Intron|NCK2_ENST00000393349.2_Missense_Mutation_p.D128N	NM_003581.4	NP_003572.2	O43639	NCK2_HUMAN	NCK adaptor protein 2	128	SH3 2.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						CGAGCGGGAGGATGAGTTGTC	0.657000													6	49					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9391690	9391690	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:9391690C>T	ENST00000378501.2	+	21	1985	c.1970C>T	c.(1969-1971)gCg>gTg	p.A657V	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378493.1_Missense_Mutation_p.A657V|PLCB4_ENST00000278655.4_Missense_Mutation_p.A657V|PLCB4_ENST00000334005.3_Missense_Mutation_p.A657V|PLCB4_ENST00000414679.2_Missense_Mutation_p.A669V|PLCB4_ENST00000378473.3_Missense_Mutation_p.A669V	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	657	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						ACAGATTTAGCGATGCAATTG	0.373000													15	44					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70849104	70849104	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:70849104G>A	ENST00000358731.4	+	35	7420	c.7157G>A	c.(7156-7158)cGt>cAt	p.R2386H	BDP1_ENST00000380675.2_Missense_Mutation_p.V460I	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	2386					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GCCAAAAAACGTTCACTCACT	0.373000													8	54					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137110	40137110	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:40137110G>T	ENST00000278198.2	-	2	2696	c.733C>A	c.(733-735)Ctt>Att	p.L245I	LRRC4C_ENST00000527150.1_Missense_Mutation_p.L245I|LRRC4C_ENST00000528697.1_Missense_Mutation_p.L245I|LRRC4C_ENST00000530763.1_Missense_Mutation_p.L245I			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	245					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				AGTTTTTGAAGGTGCATCAAA	0.448000													5	68					0.000602214	0.000633666	1	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28327086	28327086	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr21:28327086G>A	ENST00000284987.5	-	2	1330	c.1209C>T	c.(1207-1209)caC>caT	p.H403H		NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	403	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding	p.H403H(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						TGAAGGCTGCGTGGAGGCCAT	0.498000													4	54					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69434021	69434021	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:69434021G>T	ENST00000317746.2	-	1	224	c.182C>A	c.(181-183)tCt>tAt	p.S61Y		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	61					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						GACAAGAATAGAAGCCGAAGA	0.358000													46	249					1.48734e-19	1.77496e-19	1	1	0
PPWD1	23398	broad.mit.edu	37	5	64867842	64867842	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:64867842C>T	ENST00000261308.5	+	5	770	c.698C>T	c.(697-699)cCa>cTa	p.P233L	PPWD1_ENST00000538977.1_Missense_Mutation_p.P77L|PPWD1_ENST00000535264.1_Missense_Mutation_p.P203L	NM_015342.3	NP_056157.1	Q96BP3	PPWD1_HUMAN	peptidylprolyl isomerase domain and WD repeat containing 1	233					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	19		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00451)		CGGCTAAACCCAGTTTACAAA	0.398000													15	94					0	0	1	0	0
PHC3	80012	broad.mit.edu	37	3	169896669	169896669	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:169896669C>T	ENST00000495893.2	-	2	103	c.72G>A	c.(70-72)gtG>gtA	p.V24V	PHC3_ENST00000497658.1_Silent_p.V24V|PHC3_ENST00000481639.1_Silent_p.V24V|PHC3_ENST00000467570.1_Silent_p.V24V|PHC3_ENST00000494943.1_Silent_p.V12V|PHC3_ENST00000474275.1_Silent_p.V12V	NM_024947.3	NP_079223.3	Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)		Poly-Thr.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTGTTGTTGACACAGAAGATG	0.473000													37	215					0	0	1	0	0
MTURN	222166	broad.mit.edu	37	7	30197143	30197143	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:30197143G>C	ENST00000324453.8	+	3	702	c.375G>C	c.(373-375)caG>caC	p.Q125H	C7orf41_ENST00000324489.5_Missense_Mutation_p.Q92H|C7orf41_ENST00000455738.1_Missense_Mutation_p.Q92H|C7orf41_ENST00000415604.1_Missense_Mutation_p.Q125H|C7orf41_ENST00000409688.1_Missense_Mutation_p.Q84H	NM_152793.2	NP_690006.2	Q8N3F0	CG041_HUMAN		125								p.Q125Q(1)		NS(1)|large_intestine(2)	3						ACCACCCCCAGATGGGGGTCA	0.582000													19	77					0	0	1	0	0
SERPINA5	5104	broad.mit.edu	37	14	95057194	95057194	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:95057194G>A	ENST00000329597.7	+	5	1209	c.999G>A	c.(997-999)ctG>ctA	p.L333L	SERPINA5_ENST00000553780.1_Silent_p.L333L|SERPINA5_ENST00000554276.1_Silent_p.L333L|SERPINA5_ENST00000554866.1_Silent_p.L333L	NM_000624.5	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	333					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	ATGCTGATCTGTCCGGCATCA	0.488000													19	100					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62713245	62713245	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:62713245C>A	ENST00000371153.4	-	9	3160	c.2782G>T	c.(2782-2784)Gat>Tat	p.D928Y	KANK4_ENST00000354381.3_Missense_Mutation_p.D300Y|KANK4_ENST00000371150.1_Missense_Mutation_p.D284Y|KANK4_ENST00000317477.4_Missense_Mutation_p.D66Y	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	928										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						GAGGATCCATCGTGGTCCTGC	0.627000													11	59					0.00136819	0.0014265	1	1	0
NPC1L1	29881	broad.mit.edu	37	7	44578734	44578734	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:44578734C>A	ENST00000289547.4	-	2	1317	c.1262G>T	c.(1261-1263)aGg>aTg	p.R421M	NPC1L1_ENST00000381160.3_Missense_Mutation_p.R421M|NPC1L1_ENST00000546276.1_Missense_Mutation_p.R421M|NPC1L1_ENST00000423141.1_Missense_Mutation_p.R421M	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	421					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	AGAGTCATACCTGTAGCTGGA	0.592000													11	54					4.68919e-08	5.34458e-08	1	1	0
HCRTR2	3062	broad.mit.edu	37	6	55147195	55147195	+	Silent	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:55147195C>G	ENST00000370862.3	+	7	1614	c.1278C>G	c.(1276-1278)ctC>ctG	p.L426L		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	426					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAGTTGTGCTCACTAGCATAA	0.443000													3	28					0	0	1	0	0
POLR2F	5435	broad.mit.edu	37	22	38421637	38421637	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:38421637C>A	ENST00000405557.1	+	5	422	c.345C>A	c.(343-345)gcC>gcA	p.A115A	POLR2F_ENST00000407936.1_Intron			P61218	RPAB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide F	0					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA binding|DNA-directed RNA polymerase activity			breast(1)|urinary_tract(2)	3	Melanoma(58;0.045)					acgcactggcccacagcctag	0.567000													3	15					0.115264	0.116112	1	1	0
PMPCA	23203	broad.mit.edu	37	9	139310759	139310759	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:139310759G>A	ENST00000371717.3	+	6	558	c.549G>A	c.(547-549)atG>atA	p.M183I	PMPCA_ENST00000399219.3_Missense_Mutation_p.M52I|PMPCA_ENST00000462616.1_3'UTR|PMPCA_ENST00000371720.1_3'UTR	NM_001282946.1|NM_015160.1	NP_001269875.1|NP_055975.1	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	183					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|urinary_tract(1)	14		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		AAGTCGAGATGACGCGGATGG	0.547000													7	60					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114304979	114304979	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:114304979T>C	ENST00000309235.5	+	6	1922	c.1764T>C	c.(1762-1764)ttT>ttC	p.F588F	ZNF483_ENST00000358151.4_Intron	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	588					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						GAAAAGCCTTTAGGCAGAATT	0.403000													3	79					0	0	1	0	0
PAM	5066	broad.mit.edu	37	5	102343301	102343301	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:102343301G>A	ENST00000438793.3	+	19	2625	c.2155G>A	c.(2155-2157)Gtg>Atg	p.V719M	PAM_ENST00000346918.2_Missense_Mutation_p.V719M|PAM_ENST00000274392.9_Missense_Mutation_p.V622M|PAM_ENST00000379787.4_Missense_Mutation_p.V99M|PAM_ENST00000348126.2_Missense_Mutation_p.V612M|PAM_ENST00000304400.7_Missense_Mutation_p.V719M|PAM_ENST00000455264.2_Missense_Mutation_p.V719M	NM_000919.3|NM_001177306.1|NM_138766.2	NP_000910.2|NP_001170777.1|NP_620121.1	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	719	Peptidyl-alpha-hydroxyglycine alpha- amidating lyase (By similarity).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	CAAAGAATTTGTGAGAGAGAT	0.388000													4	78					0	0	1	0	0
PWWP2A	114825	broad.mit.edu	37	5	159520823	159520823	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:159520823G>A	ENST00000456329.3	-	2	868	c.834C>T	c.(832-834)atC>atT	p.I278I	PWWP2A_ENST00000523662.1_Silent_p.I278I|PWWP2A_ENST00000307063.7_Silent_p.I278I	NM_052927.2	NP_443159.1	Q96N64	PWP2A_HUMAN	PWWP domain containing 2A	278	Pro-rich.									kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATGTGTCCCTGATAAACAAAG	0.483000													14	120					0	0	1	0	0
FAM83A	84985	broad.mit.edu	37	8	124195347	124195347	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:124195347C>A	ENST00000518448.1	+	2	2265	c.251C>A	c.(250-252)aCc>aAc	p.T84N	FAM83A_ENST00000276699.6_Missense_Mutation_p.T84N|FAM83A_ENST00000536633.1_Missense_Mutation_p.T84N|FAM83A_ENST00000318462.6_Missense_Mutation_p.T84N|FAM83A_ENST00000522648.1_Missense_Mutation_p.T84N|FAM83A_ENST00000546351.1_Missense_Mutation_p.T84N			Q86UY5	FA83A_HUMAN	family with sequence similarity 83, member A	84										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(2)|skin(1)	17	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			CCCCCAGACACCCTGGGAGGG	0.682000													4	67					2.56e-06	2.83296e-06	1	1	0
DDHD1	80821	broad.mit.edu	37	14	53619005	53619005	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:53619005C>T	ENST00000357758.3	-	1	995	c.812G>A	c.(811-813)gGa>gAa	p.G271E	DDHD1_ENST00000395606.1_Missense_Mutation_p.G271E|DDHD1_ENST00000323669.5_Missense_Mutation_p.G271E	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	271					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					GTAGCACTCTCCTTGGGTCAC	0.662000													4	19					0	0	1	0	0
EIF4E3	317649	broad.mit.edu	37	3	71733849	71733849	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:71733849C>A	ENST00000425534.3	-	7	666	c.659G>T	c.(658-660)gGa>gTa	p.G220V	EIF4E3_ENST00000448225.1_Missense_Mutation_p.G114V|EIF4E3_ENST00000389826.3_Missense_Mutation_p.G114V|EIF4E3_ENST00000468147.1_5'UTR|EIF4E3_ENST00000295612.3_Missense_Mutation_p.G114V|EIF4E3_ENST00000421769.2_Missense_Mutation_p.G114V	NM_001134651.1	NP_001128123.1	Q8N5X7	IF4E3_HUMAN	eukaryotic translation initiation factor 4E family member 3						regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity			large_intestine(1)|lung(3)	4		Prostate(10;0.0166)		BRCA - Breast invasive adenocarcinoma(55;2.56e-05)|Epithelial(33;2.9e-05)|Lung(16;9.28e-05)|LUSC - Lung squamous cell carcinoma(21;0.00227)		TTTTCCACGTCCACCTTCAAA	0.393000													6	43					0.0293803	0.0298156	1	1	0
PCDHB12	56124	broad.mit.edu	37	5	140589863	140589863	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:140589863G>A	ENST00000239450.2	+	1	1573	c.1384G>A	c.(1384-1386)Gag>Aag	p.E462K	PCDHB12_ENST00000541609.1_Missense_Mutation_p.E125K	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		462	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCGTCCGCGAGAACAACAG	0.617000													19	125					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25254227	25254227	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:25254227A>T	ENST00000354454.3	+	15	1686	c.857A>T	c.(856-858)aAt>aTt	p.N286I	LRMP_ENST00000548766.1_Missense_Mutation_p.N286I|LRMP_ENST00000547044.1_Missense_Mutation_p.N286I	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	342					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					CTTCTGCAGAATGAAAGGTCT	0.348000													5	60					0	0	1	0	0
ANKIB1	54467	broad.mit.edu	37	7	91936755	91936755	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:91936755C>T	ENST00000265742.3	+	3	647	c.271C>T	c.(271-273)Caa>Taa	p.Q91*		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	91							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TATGGGACCTCAAATTATGAT	0.403000													9	37					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57552247	57552247	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:57552247G>C	ENST00000243077.3	+	11	2090	c.1624G>C	c.(1624-1626)Gat>Cat	p.D542H		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	542					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCGGGGCATGGATATGGGGGC	0.587000													3	45					0	0	1	0	0
KIAA1257	57501	broad.mit.edu	37	3	128712054	128712054	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:128712054C>T	ENST00000265068.5	-	2	261	c.94G>A	c.(94-96)Gac>Aac	p.D32N	KIAA1257_ENST00000511438.1_Missense_Mutation_p.D32N|KIAA1257_ENST00000510149.1_Intron	NM_020741.2	NP_065792.1	Q9ULG3	K1257_HUMAN	KIAA1257	32										breast(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(2)	14						TCCTCCACGTCACACTCGCTC	0.597000													11	36					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100996773	100996773	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:100996773C>A	ENST00000325455.5	-	2	3207	c.1754G>T	c.(1753-1755)gGg>gTg	p.G585V	PGR_ENST00000534013.1_5'UTR|PGR_ENST00000263463.5_Missense_Mutation_p.G585V	NM_000926.4|NM_001202474.1|NM_001271162.1	NP_000917.3|NP_001189403.1|NP_001258091.1	P06401	PRGR_HUMAN	progesterone receptor	585					cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CTTACAGCTCCCACAGGTAAG	0.428000													3	53					0.004672	0.00482703	1	1	0
COBL	23242	broad.mit.edu	37	7	51111333	51111333	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:51111333G>A	ENST00000395542.2	-	10	1583	c.1399C>T	c.(1399-1401)Ctg>Ttg	p.L467L	COBL_ENST00000265136.7_Silent_p.L385L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	385										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					GCCTCTGACAGCACCTGCGGG	0.627000													8	35					0	0	1	0	0
WDR25	79446	broad.mit.edu	37	14	100996170	100996170	+	Nonsense_Mutation	SNP	C	C	G	rs144635721		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:100996170C>G	ENST00000335290.6	+	7	1653	c.1427C>G	c.(1426-1428)tCa>tGa	p.S476*	WDR25_ENST00000402312.3_Nonsense_Mutation_p.S476*|WDR25_ENST00000554998.1_Nonsense_Mutation_p.S476*|WDR25_ENST00000542471.2_Nonsense_Mutation_p.S219*|WDR25_ENST00000557502.1_3'UTR	NM_024515.4	NP_078791.3	Q64LD2	WDR25_HUMAN	WD repeat domain 25	476										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|skin(1)	20		Melanoma(154;0.212)				GAGGGCTACTCAGTGGGCTGC	0.647000													3	35					0	0	1	0	0
SUSD5	26032	broad.mit.edu	37	3	33195406	33195406	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:33195406A>G	ENST00000309558.3	-	5	1135	c.718T>C	c.(718-720)Tcc>Ccc	p.S240P		NM_015551.1	NP_056366.1	O60279	SUSD5_HUMAN	sushi domain containing 5	240					cell adhesion	integral to membrane	hyaluronic acid binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TCCTCAGAGGAGTCTCCCTGA	0.522000													6	30					0	0	1	0	0
ONECUT2	9480	broad.mit.edu	37	18	55143752	55143752	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:55143752C>T	ENST00000491143.2	+	2	1344	c.1312C>T	c.(1312-1314)Cgc>Tgc	p.R438C		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	438					organ morphogenesis	nucleus	sequence-specific DNA binding	p.R438C(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		TGACCTCCAACGCCGAACACT	0.522000													7	31					0	0	1	0	0
RMI2	116028	broad.mit.edu	37	16	11444624	11444624	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:11444624G>A	ENST00000572173.1	+	5	877	c.232G>A	c.(232-234)Gat>Aat	p.D78N	RMI2_ENST00000381820.2_Missense_Mutation_p.D78N|RMI2_ENST00000312499.5_Missense_Mutation_p.D141N|RMI2_ENST00000576027.1_3'UTR			Q96E14	RMI2_HUMAN	RecQ mediated genome instability 2	141					DNA replication	nucleus	DNA binding			endometrium(1)|kidney(1)|ovary(1)	3						GGAGGTAGAAGATTTACACAG	0.433000													7	42					0	0	1	0	0
ARFIP2	23647	broad.mit.edu	37	11	6498959	6498959	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:6498959C>A	ENST00000254584.2	-	7	942	c.859G>T	c.(859-861)Gaa>Taa	p.E287*	ARFIP2_ENST00000396777.3_Nonsense_Mutation_p.E287*|ARFIP2_ENST00000423813.2_Nonsense_Mutation_p.E249*|ARFIP2_ENST00000445086.2_Nonsense_Mutation_p.E202*	NM_012402.3	NP_036534.1	P53365	ARFP2_HUMAN	ADP-ribosylation factor interacting protein 2	287	AH.				actin cytoskeleton organization|cellular component movement|lamellipodium assembly|ruffle organization|small GTPase mediated signal transduction	cell cortex|plasma membrane|ruffle	GTP binding|GTP-dependent protein binding|Rac GTPase binding			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|pancreas(1)|prostate(1)|skin(2)	15		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;3.41e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTGTTTTCTTCCAGGAACTTG	0.547000													11	19					0.00400662	0.00415839	1	1	0
GYS1	2997	broad.mit.edu	37	19	49484799	49484799	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:49484799C>T	ENST00000323798.3	-	8	1353	c.1157G>A	c.(1156-1158)cGc>cAc	p.R386H	GYS1_ENST00000541188.1_Missense_Mutation_p.R306H|GYS1_ENST00000540532.1_3'UTR|GYS1_ENST00000263276.6_Missense_Mutation_p.R322H|GYS1_ENST00000544287.1_Missense_Mutation_p.R19H	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	386					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		AAGCTGTTTGCGCACAGCTTG	0.567000													7	41					0	0	1	0	0
HIPK3	10114	broad.mit.edu	37	11	33308254	33308254	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:33308254G>A	ENST00000303296.4	+	2	599	c.294G>A	c.(292-294)caG>caA	p.Q98Q	HIPK3_ENST00000456517.1_Silent_p.Q98Q|HIPK3_ENST00000525975.1_Silent_p.Q98Q|HIPK3_ENST00000379016.3_Silent_p.Q98Q	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	98					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						TAGCAGCTCAGGCACAGCAAG	0.493000													4	68					0	0	1	0	0
FXN	2395	broad.mit.edu	37	9	71687607	71687607	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:71687607G>A	ENST00000377270.3	+	5	1086	c.562G>A	c.(562-564)Gca>Aca	p.A188T	FXN_ENST00000396366.2_Silent_p.P190P|FXN_ENST00000396364.3_Intron|FXN_ENST00000498653.1_Missense_Mutation_p.A113T	NM_000144.4	NP_000135.2	Q16595	FRDA_HUMAN	frataxin	188					cellular iron ion homeostasis|cellular response to hydrogen peroxide|heme biosynthetic process|ion transport|iron incorporation into metallo-sulfur cluster|negative regulation of apoptosis|negative regulation of release of cytochrome c from mitochondria|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity|protein autoprocessing|regulation of ferrochelatase activity|response to iron ion	cytosol|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferric iron binding|ferrous iron binding|ferroxidase activity|iron chaperone activity|protein binding			large_intestine(1)|lung(1)	2						GCTGCTGGCCGCAGAGCTCAC	0.493000													8	68					0	0	1	0	0
UVSSA	57654	broad.mit.edu	37	4	1379728	1379728	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:1379728G>A	ENST00000389851.4	+	14	2556	c.2109G>A	c.(2107-2109)caG>caA	p.Q703Q	UVSSA_ENST00000511216.1_Silent_p.Q703Q|UVSSA_ENST00000512728.1_Silent_p.Q254Q|UVSSA_ENST00000507531.1_Silent_p.Q703Q|UVSSA_ENST00000511563.1_Silent_p.Q254Q	NM_020894.2	NP_065945.2	Q2YD98	K1530_HUMAN	UV-stimulated scaffold protein A	703																	TTTCAAACCAGTTTAACTACG	0.567000													5	27					0	0	1	0	0
LIPF	8513	broad.mit.edu	37	10	90438298	90438298	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:90438298C>T	ENST00000394375.3	+	11	1200	c.1087C>T	c.(1087-1089)Ctt>Ttt	p.L363F	LIPF_ENST00000238983.4_Missense_Mutation_p.L353F|LIPF_ENST00000355843.2_Missense_Mutation_p.L330F|LIPF_ENST00000608620.1_Missense_Mutation_p.L320F	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	353					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		AGATGTTGGCCTTTTGCTTCC	0.463000													16	92					0	0	1	0	0
MPP2	4355	broad.mit.edu	37	17	41958128	41958128	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:41958128C>T	ENST00000269095.4	-	10	1385	c.1081G>A	c.(1081-1083)Gtg>Atg	p.V361M	MPP2_ENST00000520305.1_Missense_Mutation_p.V222M|MPP2_ENST00000461854.1_Missense_Mutation_p.V385M|MPP2_ENST00000377184.3_Missense_Mutation_p.V378M|MPP2_ENST00000536246.1_Missense_Mutation_p.V350M|MPP2_ENST00000523501.1_Missense_Mutation_p.V350M|MPP2_ENST00000518766.1_Missense_Mutation_p.V406M	NM_001278370.1|NM_001278381.1|NM_005374.3	NP_001265299.1|NP_001265310.1|NP_005365	Q14168	MPP2_HUMAN	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	385					signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|liver(1)|lung(4)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CGCCGTCCCACGCCCTGAGCC	0.612000											OREG0024443	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	38					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29997772	29997772	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:29997772G>C	ENST00000308893.4	+	16	3222	c.2179G>C	c.(2179-2181)Gag>Cag	p.E727Q	TAOK2_ENST00000416441.2_Missense_Mutation_p.E554Q|TAOK2_ENST00000279394.3_Missense_Mutation_p.E727Q|TAOK2_ENST00000543033.1_Missense_Mutation_p.E727Q	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	727					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity	p.E727*(2)		breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						GCGTGAGCAAGAGTTGCGGCA	0.677000													11	55					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586513	20586513	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:20586513T>C	ENST00000315543.4	+	1	948	c.948T>C	c.(946-948)atT>atC	p.I316I		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TGAATCCAATTATCTATACTC	0.353000													6	51					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160016602	160016602	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:160016602T>C	ENST00000327245.5	-	24	4593	c.3747A>G	c.(3745-3747)acA>acG	p.T1249T		NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1249					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CACTTACCCATGTCTTCATTT	0.438000													7	33					0	0	1	0	0
TRDN	10345	broad.mit.edu	37	6	123892070	123892070	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:123892070G>A	ENST00000334268.4	-	2	547	c.230C>T	c.(229-231)tCa>tTa	p.S77L	TRDN_ENST00000398178.3_Missense_Mutation_p.S77L|TRDN_ENST00000546248.1_Missense_Mutation_p.S77L|TRDN_ENST00000542443.1_Missense_Mutation_p.S77L			Q13061	TRDN_HUMAN	triadin	77					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		GAACTTACCTGAAAAGTTTTT	0.393000													6	45					0	0	1	0	0
TRAPPC11	60684	broad.mit.edu	37	4	184626154	184626154	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:184626154C>A	ENST00000334690.6	+	27	3188	c.2986C>A	c.(2986-2988)Ccc>Acc	p.P996T	TRAPPC11_ENST00000357207.4_Missense_Mutation_p.P996T|TRAPPC11_ENST00000512476.1_Missense_Mutation_p.P602T	NM_021942.5	NP_068761.4	Q7Z392	CD041_HUMAN	trafficking protein particle complex 11	996																	GGAGAATATCCCCATCATCAC	0.388000													14	155					1.05317e-09	1.21044e-09	1	1	0
UBLCP1	134510	broad.mit.edu	37	5	158705319	158705319	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:158705319A>G	ENST00000296786.6	+	9	1084	c.758A>G	c.(757-759)gAc>gGc	p.D253G		NM_145049.3	NP_659486.2	Q8WVY7	UBCP1_HUMAN	ubiquitin-like domain containing CTD phosphatase 1	253	FCP1 homology.					nucleus	phosphoprotein phosphatase activity			endometrium(1)|kidney(3)|large_intestine(4)|ovary(1)	9	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATGTTTGATGACATAGGGAGA	0.353000													14	72					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12726318	12726318	+	Missense_Mutation	SNP	G	G	A	rs139261871	by1000genomes	TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:12726318G>A	ENST00000376221.1	+	4	796	c.796G>A	c.(796-798)Gcc>Acc	p.A266T		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	266						integral to membrane	carboxylesterase activity	p.A266T(2)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		CTGGCGTGACGCCATCTTGAA	0.502000													24	95					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102549577	102549577	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:102549577C>T	ENST00000334701.7	-	10	2196	c.1915G>A	c.(1915-1917)Gaa>Aaa	p.E639K	HSP90AA1_ENST00000441629.2_Missense_Mutation_p.E338K|HSP90AA1_ENST00000216281.8_Missense_Mutation_p.E517K	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	517					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	TAGATCACTTCTAAGCCATGT	0.438000													10	92					0	0	1	0	0
OBFC1	79991	broad.mit.edu	37	10	105657467	105657467	+	Missense_Mutation	SNP	C	C	T	rs139991163		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:105657467C>T	ENST00000224950.3	-	7	759	c.592G>A	c.(592-594)Gcc>Acc	p.A198T	OBFC1_ENST00000369764.1_Missense_Mutation_p.A198T|OBFC1_ENST00000466828.1_5'UTR	NM_024928.4	NP_079204.2	Q9H668	STN1_HUMAN	oligonucleotide/oligosaccharide-binding fold containing 1	198					positive regulation of DNA replication|telomere maintenance via telomere lengthening		protein binding|single-stranded telomeric DNA binding			large_intestine(3)|lung(7)|ovary(1)|pancreas(2)	13		Colorectal(252;0.178)		Epithelial(162;3.39e-10)|all cancers(201;1.32e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0151)		AGGTCCAGGGCGCCTGGATTG	0.448000													6	62					0	0	1	0	0
CD244	51744	broad.mit.edu	37	1	160808287	160808287	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:160808287A>G	ENST00000368034.4	-	5	965	c.788T>C	c.(787-789)tTg>tCg	p.L263S	CD244_ENST00000481677.1_5'UTR|CD244_ENST00000368033.3_Missense_Mutation_p.L268S|CD244_ENST00000322302.7_Missense_Mutation_p.L171S|CD244_ENST00000368032.2_Missense_Mutation_p.L263S	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	268					blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GTAAATTGTCAAAAATTCCTT	0.478000													22	85					0	0	1	0	0
RPA4	29935	broad.mit.edu	37	X	96139744	96139744	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:96139744T>C	ENST00000373040.3	+	1	838	c.435T>C	c.(433-435)atT>atC	p.I145I	DIAPH2_ENST00000373054.4_Intron|DIAPH2_ENST00000373049.4_Intron|DIAPH2_ENST00000355827.4_Intron|DIAPH2_ENST00000373061.3_Intron|DIAPH2_ENST00000324765.8_Intron	NM_013347.4	NP_037479.1	Q13156	RFA4_HUMAN	replication protein A4, 30kDa	145					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	13						TATTGAAAATTCATGTCCTAG	0.448000								Other identified genes with known or suspected DNA repair function					11	37					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	712373	712373	+	Missense_Mutation	SNP	C	C	T	rs149011172		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:712373C>T	ENST00000382303.1	+	7	2259	c.1607C>T	c.(1606-1608)aCg>aTg	p.T536M	KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382293.3_Missense_Mutation_p.T378M|KANK1_ENST00000382297.2_Missense_Mutation_p.T536M	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	536					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		CTGGTGGACACGTGTGTTGGG	0.542000													15	46					0	0	1	0	0
CYB561D2	11068	broad.mit.edu	37	3	50390809	50390809	+	Silent	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:50390809C>G	ENST00000418577.1	+	3	879	c.303C>G	c.(301-303)ctC>ctG	p.L101L	CYB561D2_ENST00000424512.1_Silent_p.L101L|XXcos-LUCA11.5_ENST00000606589.1_Intron|CYB561D2_ENST00000419046.1_3'UTR|CYB561D2_ENST00000232508.5_Silent_p.L101L|CYB561D2_ENST00000425346.1_Silent_p.L101L			O14569	C56D2_HUMAN	cytochrome b561 family, member D2	101	Cytochrome b561.				electron transport chain|transport	integral to membrane	metal ion binding			endometrium(1)|lung(1)|urinary_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TGCTGGGCCTCGGCCTTGTCA	0.652000													4	38					0	0	1	0	0
RNF44	22838	broad.mit.edu	37	5	175956034	175956034	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:175956034C>G	ENST00000274811.4	-	11	1818	c.1294G>C	c.(1294-1296)Gag>Cag	p.E432Q	RNF44_ENST00000537487.1_Missense_Mutation_p.E351Q	NM_014901.4	NP_055716.1	Q7L0R7	RNF44_HUMAN	ring finger protein 44	432							zinc ion binding			endometrium(2)|lung(3)|prostate(1)|skin(1)|stomach(1)	8	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGCCTCACTCAGCCTCCCTG	0.687000													3	15					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179621091	179621091	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:179621091C>T	ENST00000589042.1	-	46	11336	c.11112G>A	c.(11110-11112)gaG>gaA	p.E3704E	TTN_ENST00000360870.5_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Silent_p.E3533E|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3388	Ig-like 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTCAGTCTCTCGGATTCCT	0.393000													14	51					0	0	1	0	0
ARMCX2	9823	broad.mit.edu	37	X	100911930	100911930	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:100911930G>T	ENST00000328766.5	-	5	1098	c.645C>A	c.(643-645)acC>acA	p.T215T	ARMCX2_ENST00000330154.2_Silent_p.T215T|ARMCX2_ENST00000356824.4_Silent_p.T215T	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	215	Ala-rich.					integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						CAGCTGCCTCGGTAGGCGATG	0.647000													7	26					5.68852e-11	6.58216e-11	1	1	0
CREB5	9586	broad.mit.edu	37	7	28848874	28848874	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:28848874G>A	ENST00000357727.2	+	9	1487	c.1097G>A	c.(1096-1098)cGg>cAg	p.R366Q	CREB5_ENST00000396298.2_Missense_Mutation_p.R227Q|CREB5_ENST00000409603.1_Missense_Mutation_p.R333Q|CREB5_ENST00000396299.2_Missense_Mutation_p.R333Q|CREB5_ENST00000396300.2_Missense_Mutation_p.R359Q	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	366					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						GGGGGGCGCCGGCGAAGGGTG	0.632000													11	53					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54967285	54967285	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:54967285G>T	ENST00000326764.5	+	9	1644	c.1165G>T	c.(1165-1167)Ggt>Tgt	p.G389C	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	352	Ser-rich.						protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		CGGGGCTGGGGGTGCCGGTCG	0.687000													11	37					6.42651e-13	7.52506e-13	1	1	0
CYB561D2	11068	broad.mit.edu	37	3	50391055	50391055	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:50391055C>T	ENST00000418577.1	+	3	1125	c.549C>T	c.(547-549)ttC>ttT	p.F183F	CYB561D2_ENST00000424512.1_Silent_p.F183F|XXcos-LUCA11.5_ENST00000606589.1_Intron|CYB561D2_ENST00000232508.5_Silent_p.F183F|CYB561D2_ENST00000425346.1_Silent_p.F183F			O14569	C56D2_HUMAN	cytochrome b561 family, member D2	183	Cytochrome b561.				electron transport chain|transport	integral to membrane	metal ion binding			endometrium(1)|lung(1)|urinary_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		CACTCTGGTTCACTGCCTCTG	0.567000													33	127					0	0	1	0	0
MROH6	642475	broad.mit.edu	37	8	144654243	144654243	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:144654243G>A	ENST00000398882.3	-	2	663	c.407C>T	c.(406-408)tCc>tTc	p.S136F		NM_001100878.1	NP_001094348.1			maestro heat-like repeat family member 6																		CAGGGCTGAGGACAGGGTGAG	0.657000													5	22					0	0	1	0	0
NAT10	55226	broad.mit.edu	37	11	34156814	34156814	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:34156814G>T	ENST00000257829.3	+	19	2210	c.2004G>T	c.(2002-2004)caG>caT	p.Q668H	NAT10_ENST00000531159.2_Missense_Mutation_p.Q596H|NAT10_ENST00000527971.1_Intron	NM_024662.2	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 (GCN5-related)	668	N-acetyltransferase.					nucleolus	ATP binding|N-acetyltransferase activity|protein binding			endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				AGACACCACAGGAAATTCACA	0.512000													9	78					2.74318e-10	3.16877e-10	1	1	0
RAG1	5896	broad.mit.edu	37	11	36597335	36597335	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:36597335G>T	ENST00000299440.5	+	2	2593	c.2481G>T	c.(2479-2481)gaG>gaT	p.E827D		NM_000448.2	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	827					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				CTTCCAAAGAGGAAAGGAAAA	0.468000									Familial Hemophagocytic Lymphohistiocytosis				10	42					4.68919e-08	5.34458e-08	1	1	0
CACNG4	27092	broad.mit.edu	37	17	65021114	65021114	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:65021114C>T	ENST00000262138.3	+	3	445	c.443C>T	c.(442-444)gCa>gTa	p.A148V		NM_014405.3	NP_055220.1	Q9UBN1	CCG4_HUMAN	calcium channel, voltage-dependent, gamma subunit 4	148					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(3)	19	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			TTCGTGGCTGCAGGTGAGCCG	0.657000													5	37					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6966191	6966191	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:6966191G>T	ENST00000389658.3	-	49	7098	c.7005C>A	c.(7003-7005)acC>acA	p.T2335T		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2335	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAGGTGAAAAGGTATTAAAAA	0.463000													6	18					0.0293803	0.0298156	1	1	0
CIRH1A	84916	broad.mit.edu	37	16	69167477	69167477	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:69167477A>G	ENST00000563094.1	+	2	149	c.115A>G	c.(115-117)Act>Gct	p.T39A	CIRH1A_ENST00000352319.4_Missense_Mutation_p.T39A|CIRH1A_ENST00000314423.7_Missense_Mutation_p.T39A			Q969X6	CIR1A_HUMAN	cirrhosis, autosomal recessive 1A (cirhin)	39						nucleolus	protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(108;0.125)		AACAGATGGCACTGTGGAAAT	0.388000													8	93					0	0	1	0	0
FYN	2534	broad.mit.edu	37	6	112025286	112025286	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:112025286C>T	ENST00000354650.3	-	7	1069	c.463G>A	c.(463-465)Ggc>Agc	p.G155S	FYN_ENST00000229471.4_Missense_Mutation_p.G155S|FYN_ENST00000368678.4_Missense_Mutation_p.G155S|FYN_ENST00000368682.3_Missense_Mutation_p.G155S|FYN_ENST00000356013.2_Missense_Mutation_p.G155S|FYN_ENST00000229470.5_Missense_Mutation_p.G106S|FYN_ENST00000368667.2_Missense_Mutation_p.G155S|FYN_ENST00000538466.1_Missense_Mutation_p.G155S|FYN_ENST00000476769.2_5'UTR	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	155	SH2.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TCTTTTCGGCCAAGTTTTCCA	0.383000													13	71					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145568068	145568068	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:145568068C>T	ENST00000296575.3	+	1	896	c.241C>T	c.(241-243)Cgg>Tgg	p.R81W	HHIP-AS1_ENST00000512359.1_RNA|HHIP_ENST00000434550.2_Missense_Mutation_p.R81W	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	81						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		CTGCTGCCTGCGGAGTGACAG	0.617000													5	56					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538475	4538475	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:4538475T>C	ENST00000306390.6	-	2	981	c.521A>G	c.(520-522)aAc>aGc	p.N174S	CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	174						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGAGGCGGTTCCCAGACAG	0.617000													6	120					0	0	1	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839278	100839278	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:100839278C>T	ENST00000379423.3	-	6	832	c.772G>A	c.(772-774)Gca>Aca	p.A258T	MOGAT3_ENST00000223114.4_Silent_p.E325E|MOGAT3_ENST00000440203.2_3'UTR			Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	0					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(3)	22	Lung NSC(181;0.168)|all_lung(186;0.215)					TTTCCTTGTGCTCCTCGAAGA	0.657000													11	36					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75130444	75130444	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:75130444G>A	ENST00000356357.4	-	20	2966	c.2451C>T	c.(2449-2451)tgC>tgT	p.C817C	AREL1_ENST00000557401.1_Intron	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		CAAAGCCCTCGCAACCCTCGC	0.542000													14	96					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3116332	3116332	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:3116332C>T	ENST00000356443.4	-	21	3633	c.3300G>A	c.(3298-3300)ctG>ctA	p.L1100L	MYOM1_ENST00000261606.7_Silent_p.L1004L|MYOM1_ENST00000400569.3_Silent_p.L1100L	NM_003803.3|NM_019856.1	NP_003794.3|NP_062830.1	P52179	MYOM1_HUMAN	myomesin 1	1100	Fibronectin type-III 5.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CTCTTACCTTCAGGTATACGT	0.458000													3	18					0	0	1	0	0
NKAPL	222698	broad.mit.edu	37	6	28227933	28227933	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:28227933G>C	ENST00000343684.3	+	1	836	c.784G>C	c.(784-786)Gaa>Caa	p.E262Q		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	262										breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						GGACTTGTCAGAAGCTACCTG	0.368000													6	19					0	0	1	0	0
FAM122A	116224	broad.mit.edu	37	9	71395699	71395699	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:71395699G>A	ENST00000394264.3	+	1	736	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	PIP5K1B_ENST00000265382.3_Intron|PIP5K1B_ENST00000541509.1_Intron	NM_138333.3	NP_612206.3	Q96E09	F122A_HUMAN	family with sequence similarity 122A	207										endometrium(1)|lung(2)	3						AAGAAAATGTGAAATGGAAAC	0.468000													19	85					0	0	1	0	0
SKIL	6498	broad.mit.edu	37	3	170108923	170108923	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:170108923C>G	ENST00000458537.3	+	5	2480	c.1771C>G	c.(1771-1773)Caa>Gaa	p.Q591E	SKIL_ENST00000259119.4_Missense_Mutation_p.Q591E|SKIL_ENST00000426052.2_Missense_Mutation_p.Q571E|SKIL_ENST00000413427.2_Missense_Mutation_p.Q545E	NM_001145097.2|NM_001248008.1|NM_005414.4	NP_001138569.1|NP_001234937.1|NP_005405.2	P12757	SKIL_HUMAN	SKI-like oncogene	591					cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(12)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	25	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TGAACATGCTCAAAGAATGGA	0.323000													6	42					0	0	1	0	0
CPNE1	8904	broad.mit.edu	37	20	34219050	34219050	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:34219050G>A	ENST00000317619.3	-	12	1241	c.847C>T	c.(847-849)Cag>Tag	p.Q283*	CPNE1_ENST00000397446.1_Nonsense_Mutation_p.Q283*|CPNE1_ENST00000352393.4_Nonsense_Mutation_p.Q283*|CPNE1_ENST00000317677.5_Nonsense_Mutation_p.Q288*|CPNE1_ENST00000397443.1_Nonsense_Mutation_p.Q283*|CPNE1_ENST00000397445.1_Nonsense_Mutation_p.Q283*|CPNE1_ENST00000397442.1_Nonsense_Mutation_p.Q283*			Q99829	CPNE1_HUMAN	copine I	283					lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			breast(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			AAGTTGATCTGACAGCCTCCC	0.527000													20	125					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27324745	27324745	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:27324745C>T	ENST00000407991.1	-	5	1058		c.e5+1		CHRNA2_ENST00000240132.2_Splice_Site|CHRNA2_ENST00000520933.2_Splice_Site	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)							cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	TGGCTTCCTACTTGTTGTAGA	0.587000													4	34					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10447205	10447205	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:10447205T>A	ENST00000326756.3	-	3	1186	c.748A>T	c.(748-750)Act>Tct	p.T250S		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						TGAAATGTAGTCCGTGGATTG	0.428000													8	132					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79732690	79732690	+	Silent	SNP	C	C	T	rs144412842		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:79732690C>T	ENST00000338008.5	+	3	366	c.186C>T	c.(184-186)tgC>tgT	p.C62C	ZFYVE16_ENST00000510158.1_Silent_p.C62C|ZFYVE16_ENST00000505560.1_Silent_p.C62C	NM_001284236.1|NM_014733.3	NP_001271165.1|NP_055548	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	62					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		ACCAAGAGTGCGTTAATAGTT	0.388000													6	58					0	0	1	0	0
CHMP1B	57132	broad.mit.edu	37	18	11851857	11851857	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:11851857A>T	ENST00000526991.2	+	1	463	c.347A>T	c.(346-348)gAc>gTc	p.D116V	GNAL_ENST00000269162.5_Intron|GNAL_ENST00000535121.1_Intron|GNAL_ENST00000423027.3_Intron|GNAL_ENST00000334049.6_Intron|RP11-78A19.3_ENST00000586474.1_RNA	NM_020412.4	NP_065145.2	Q7LBR1	CHM1B_HUMAN	charged multivesicular body protein 1B	116					cell cycle|cell division|protein transport	cytosol|late endosome membrane	protein domain specific binding			endometrium(1)|lung(1)|urinary_tract(1)	3						GCTTTGATGGACAAATTCGAG	0.517000													21	104					0	0	1	0	0
IMMT	10989	broad.mit.edu	37	2	86389171	86389171	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:86389171C>T	ENST00000410111.3	-	8	1211	c.824G>A	c.(823-825)cGc>cAc	p.R275H	IMMT_ENST00000449247.2_Missense_Mutation_p.R264H|IMMT_ENST00000442664.2_Missense_Mutation_p.R274H|IMMT_ENST00000490238.1_5'UTR|IMMT_ENST00000254636.5_Missense_Mutation_p.R176H|IMMT_ENST00000409051.2_Missense_Mutation_p.R228H	NM_001100169.1|NM_001100170.1|NM_006839.2	NP_001093639.1|NP_001093640.1|NP_006830.2	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial	275						integral to mitochondrial inner membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CTCCACTGTGCGCCACTGAGC	0.388000													4	4					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144941425	144941425	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:144941425C>T	ENST00000525985.1	-	2	6068	c.5997G>A	c.(5995-5997)gaG>gaA	p.E1999E				P58107	EPIPL_HUMAN	epiplakin 1	1999						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTCCGCCTTCTCGATGAGCT	0.637000													6	31					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9964871	9964871	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:9964871C>A	ENST00000264833.4	-	6	1541	c.1356G>T	c.(1354-1356)ggG>ggT	p.G452G	OLFM2_ENST00000590841.1_Silent_p.G374G	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	452						extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						CTCAGGGGTCCCCAGAGGTGC	0.622000													11	35					0.000673444	0.000707529	1	1	0
RERE	473	broad.mit.edu	37	1	8420263	8420263	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:8420263C>G	ENST00000337907.3	-	19	3938	c.3304G>C	c.(3304-3306)Gag>Cag	p.E1102Q	RERE_ENST00000400907.2_Intron|RERE_ENST00000377464.1_Missense_Mutation_p.E834Q|RERE_ENST00000476556.1_Missense_Mutation_p.E548Q|RERE_ENST00000400908.2_Missense_Mutation_p.E1102Q	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1102	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TCAGGCTCCTCAGCGTCGTCC	0.687000													4	4					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	41988414	41988414	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:41988414G>A	ENST00000219905.7	+	3	1387	c.1206G>A	c.(1204-1206)gtG>gtA	p.V402V	MGA_ENST00000570161.1_Silent_p.V402V|MGA_ENST00000568630.1_3'UTR|MGA_ENST00000545763.1_Silent_p.V402V|MGA_ENST00000389936.4_Silent_p.V402V|MGA_ENST00000566586.1_Silent_p.V402V	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	402						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GGGTCACTGTGAAACAGGAAG	0.423000													8	48					0	0	1	0	0
ZNF224	7767	broad.mit.edu	37	19	44611954	44611954	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:44611954G>C	ENST00000336976.6	+	6	1895	c.1641G>C	c.(1639-1641)aaG>aaC	p.K547N	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	547					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				AATGTGGGAAGAGTTTTGGCT	0.418000													11	62					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119912262	119912262	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:119912262C>G	ENST00000464295.1	-	4	688	c.243G>C	c.(241-243)aaG>aaC	p.K81N	GPR156_ENST00000315843.3_Missense_Mutation_p.K81N|GPR156_ENST00000461057.1_Missense_Mutation_p.K81N			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	81						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		GACTGGACATCTTCACAATCC	0.483000													3	44					0	0	1	0	0
TLX2	3196	broad.mit.edu	37	2	74742049	74742049	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:74742049G>A	ENST00000233638.7	+	1	439	c.116G>A	c.(115-117)cGc>cAc	p.R39H	TLX2_ENST00000497238.1_Intron	NM_016170.4	NP_057254.1	O43763	TLX2_HUMAN	T-cell leukemia homeobox 2	39	Gly-rich.			LGRGGQGHGENG -> WVAGQVIGEWA (in Ref. 2; CAA05636).		nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|ovary(1)	2						GGCCTGGGTCGCGGGGGCCAG	0.692000													3	14					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63030528	63030528	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:63030528A>G	ENST00000561311.1	+	29	3913	c.3683A>G	c.(3682-3684)gAt>gGt	p.D1228G	TLN2_ENST00000559908.1_3'UTR|TLN2_ENST00000306829.6_Missense_Mutation_p.D1228G			Q9Y4G6	TLN2_HUMAN	talin 2	1228					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						CTGCTTGTGGATTCGGTGAGA	0.517000													14	56					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9020804	9020804	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:9020804A>G	ENST00000397910.4	-	20	37501	c.37298T>C	c.(37297-37299)gTt>gCt	p.V12433A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12435	SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGAGGGCCAACACTGGTGTT	0.547000													28	95					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156643193	156643193	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:156643193C>T	ENST00000296518.7	+	9	1929	c.1720C>T	c.(1720-1722)Cga>Tga	p.R574*	GUCY1A3_ENST00000455639.2_Nonsense_Mutation_p.R574*|GUCY1A3_ENST00000393832.3_Nonsense_Mutation_p.R316*|GUCY1A3_ENST00000506455.1_Nonsense_Mutation_p.R574*|GUCY1A3_ENST00000513574.1_Nonsense_Mutation_p.R574*|GUCY1A3_ENST00000511108.1_Nonsense_Mutation_p.R574*|GUCY1A3_ENST00000511507.1_Nonsense_Mutation_p.R574*			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	574	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CTTTCAGATGCGAATTGGACT	0.398000													34	283					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176722266	176722266	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:176722266C>T	ENST00000439151.2	+	23	7942	c.7897C>T	c.(7897-7899)Cgg>Tgg	p.R2633W	NSD1_ENST00000347982.4_Missense_Mutation_p.R2364W|NSD1_ENST00000354179.4_Missense_Mutation_p.R2364W|NSD1_ENST00000361032.4_Missense_Mutation_p.R2530W	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2633					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGCCTCATCACGGGCAGGGCT	0.577000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			6	50					0	0	1	0	0
CASP3	836	broad.mit.edu	37	4	185550579	185550579	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:185550579G>T	ENST00000308394.4	-	8	943	c.681C>A	c.(679-681)gcC>gcA	p.A227A	CASP3_ENST00000393588.4_3'UTR|CASP3_ENST00000523916.1_Silent_p.A227A|CASP3_ENST00000517513.1_3'UTR|CASP3_ENST00000393585.2_3'UTR	NM_004346.3	NP_004337.2	P42574	CASP3_HUMAN	caspase 3, apoptosis-related cysteine peptidase	227					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|negative regulation of apoptosis|nerve growth factor receptor signaling pathway|nuclear fragmentation involved in apoptotic nuclear change|proteolysis|response to tumor necrosis factor	cytosol|mitochondrion|nucleoplasm|plasma membrane	cysteine-type endopeptidase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.057)|all_hematologic(60;0.0592)		all cancers(43;2.05e-27)|Epithelial(43;4.27e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.04e-11)|Colorectal(24;2e-05)|STAD - Stomach adenocarcinoma(60;2.35e-05)|GBM - Glioblastoma multiforme(59;4.94e-05)|COAD - Colon adenocarcinoma(29;0.00017)|BRCA - Breast invasive adenocarcinoma(30;0.000218)|LUSC - Lung squamous cell carcinoma(40;0.00904)|READ - Rectum adenocarcinoma(43;0.161)	Melatonin(DB01065)|Minocycline(DB01017)|Simvastatin(DB00641)	CAAGCTTGTCGGCATACTGTT	0.413000													12	70					2.27111e-07	2.55873e-07	1	1	0
LRFN3	79414	broad.mit.edu	37	19	36430655	36430655	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:36430655C>T	ENST00000588831.1	+	3	1382	c.328C>T	c.(328-330)Cgt>Tgt	p.R110C	LRFN3_ENST00000246529.3_Missense_Mutation_p.R110C			Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III domain containing 3	110					cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane				cervix(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	12	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCGGGCCCTGCGTGCCCTGCA	0.687000													8	36					0	0	1	0	0
ISM1	140862	broad.mit.edu	37	20	13279672	13279672	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:13279672A>G	ENST00000262487.4	+	6	967	c.961A>G	c.(961-963)Agc>Ggc	p.S321G	TASP1_ENST00000539805.1_Intron	NM_080826.1	NP_543016.1	B1AKI9	ISM1_HUMAN	isthmin 1, angiogenesis inhibitor		AMOP.					extracellular region				NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(8)|lung(5)|urinary_tract(1)	17						TGACCTGCCCAGCTGCCCCTG	0.577000													3	28					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74365248	74365248	+	Silent	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:74365248G>C	ENST00000377044.4	-	2	581	c.42C>G	c.(40-42)ctC>ctG	p.L14L	TMEM2_ENST00000377066.5_Silent_p.L14L	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	14						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TCTGAGGTTGGAGGAAAGCAG	0.453000													7	42					0	0	1	0	0
EDC4	23644	broad.mit.edu	37	16	67914112	67914112	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:67914112C>T	ENST00000358933.5	+	17	2329	c.2090C>T	c.(2089-2091)cCg>cTg	p.P697L		NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	697					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CCCAAGGGGCCGGGCCAGGTG	0.667000													5	45					0	0	1	0	0
NDC80	10403	broad.mit.edu	37	18	2616573	2616573	+	Nonstop_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:2616573A>G	ENST00000261597.4	+	17	2111	c.1929A>G	c.(1927-1929)tgA>tgG	p.*643W		NM_006101.2	NP_006092.1	O14777	NDC80_HUMAN	NDC80 kinetochore complex component	0					attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			NS(1)|biliary_tract(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)|urinary_tract(2)	22						CTGAAGAATGAAGATAAAATG	0.284000													4	41					0	0	1	0	0
PREPL	9581	broad.mit.edu	37	2	44559681	44559681	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:44559681C>T	ENST00000541738.1	-	8	1389	c.1003G>A	c.(1003-1005)Gaa>Aaa	p.E335K	PREPL_ENST00000410081.1_Missense_Mutation_p.E424K|PREPL_ENST00000409411.1_Missense_Mutation_p.E335K|PREPL_ENST00000260648.6_Missense_Mutation_p.E424K|PREPL_ENST00000409957.1_Missense_Mutation_p.E335K|PREPL_ENST00000409272.1_Missense_Mutation_p.E424K|PREPL_ENST00000378520.3_Intron|PREPL_ENST00000378511.3_Missense_Mutation_p.E362K|PREPL_ENST00000409936.1_Missense_Mutation_p.E424K	NM_001171617.1	NP_001165088.1	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like	424					proteolysis	cytosol	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(19)|ovary(1)|prostate(1)|skin(2)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGTTTGCCTTCTGCAAACTTG	0.413000													12	73					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239281	5239281	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:5239281T>A	ENST00000274181.7	+	15	2310	c.2172T>A	c.(2170-2172)aaT>aaA	p.N724K	ADAMTS16_ENST00000513709.1_3'UTR	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	724	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						GATGTGACAATGTCCTTGGAT	0.488000													29	192					0	0	1	0	0
USP37	57695	broad.mit.edu	37	2	219350409	219350409	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:219350409G>A	ENST00000258399.3	-	16	2060	c.1648C>T	c.(1648-1650)Cac>Tac	p.H550Y	USP37_ENST00000418019.1_Missense_Mutation_p.H550Y|USP37_ENST00000454775.1_Missense_Mutation_p.H550Y|USP37_ENST00000415516.1_Missense_Mutation_p.H478Y|USP37_ENST00000475553.1_5'UTR	NM_020935.2	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	550					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TTAAATTTGTGCCTGACAAGA	0.338000													14	71					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86123700	86123700	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:86123700G>A	ENST00000394518.2	+	7	2496	c.2401G>A	c.(2401-2403)Gca>Aca	p.A801T	AKAP13_ENST00000361243.2_Missense_Mutation_p.A801T	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	801					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity	p.A801T(1)		NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						CAAGGATGACGCACTTTCTTT	0.443000													32	117					0	0	1	0	0
MTSS1	9788	broad.mit.edu	37	8	125575163	125575163	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:125575163A>G	ENST00000518547.1	-	10	1368	c.895T>C	c.(895-897)Tac>Cac	p.Y299H	NDUFB9_ENST00000522532.1_Intron|MTSS1_ENST00000325064.5_Missense_Mutation_p.Y303H|MTSS1_ENST00000524090.1_Missense_Mutation_p.Y189H|MTSS1_ENST00000354184.4_Missense_Mutation_p.Y99H|MTSS1_ENST00000431961.2_Missense_Mutation_p.Y99H|MTSS1_ENST00000378017.3_Missense_Mutation_p.Y299H|MTSS1_ENST00000395508.2_Missense_Mutation_p.Y33H|MTSS1_ENST00000523587.1_5'UTR	NM_001282971.1|NM_014751.4	NP_001269900.1|NP_055566.3	O43312	MTSS1_HUMAN	metastasis suppressor 1	299	Ser-rich.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CGGTAGCGGTAATGTGAGCTG	0.617000													5	21					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33545228	33545228	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:33545228C>G	ENST00000242067.6	+	20	2790	c.2269C>G	c.(2269-2271)Ctg>Gtg	p.L757V	BBS9_ENST00000396127.2_Missense_Mutation_p.L722V|BBS9_ENST00000350941.3_Missense_Mutation_p.L717V|BBS9_ENST00000355070.2_Missense_Mutation_p.L752V|BBS9_ENST00000354265.4_Missense_Mutation_p.L722V	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	757					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding	p.L757L(2)	BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			AGCGGCATTTCTGCCGCTACA	0.488000									Bardet-Biedl syndrome				11	32					0	0	1	0	0
EDA	1896	broad.mit.edu	37	X	69253281	69253281	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:69253281G>A	ENST00000374552.4	+	7	1069	c.827G>A	c.(826-828)cGc>cAc	p.R276H	EDA_ENST00000524573.1_Missense_Mutation_p.R273H|EDA_ENST00000374553.2_Missense_Mutation_p.R276H	NM_001399.4	NP_001390.1	Q92838	EDA_HUMAN	ectodysplasin A	276					cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|urinary_tract(1)	14						GACTGGTCTCGCATCACTATG	0.483000											OREG0019847	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	56					0	0	1	0	0
OR51F1	256892	broad.mit.edu	37	11	4790464	4790464	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:4790464G>A	ENST00000380383.1	-	1	704	c.705C>T	c.(703-705)ctC>ctT	p.L235L	OR51F1_ENST00000343430.3_Silent_p.L228L|MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	228						integral to membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		AGGCAATTCTGAGGACAGAGT	0.458000													4	74					0	0	1	0	0
RSRC2	65117	broad.mit.edu	37	12	122995696	122995696	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:122995696C>G	ENST00000331738.7	-	7	910	c.765G>C	c.(763-765)aaG>aaC	p.K255N	RSRC2_ENST00000354654.2_Missense_Mutation_p.K207N|RSRC2_ENST00000392442.2_5'UTR	NM_023012.5	NP_075388.2	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2	255										breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|urinary_tract(2)	24	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		CAACCATTTCCTTTTCTCGCT	0.279000													7	35					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129921190	129921190	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:129921190C>T	ENST00000368654.3	-	4	617	c.242G>A	c.(241-243)cGg>cAg	p.R81Q	MKI67_ENST00000368653.3_Missense_Mutation_p.R81Q	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	81					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				ATGTTTTAGCCGTACAGGCTC	0.348000													7	54					0	0	1	0	0
PDPR	55066	broad.mit.edu	37	16	70190472	70190472	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:70190472C>G	ENST00000288050.4	+	19	3287	c.2330C>G	c.(2329-2331)tCa>tGa	p.S777*	PDPR_ENST00000567046.1_Nonsense_Mutation_p.S135*|PDPR_ENST00000542659.1_Nonsense_Mutation_p.S122*|PDPR_ENST00000568530.1_Nonsense_Mutation_p.S777*|RP11-296I10.3_ENST00000566989.1_RNA|PDPR_ENST00000398122.3_Nonsense_Mutation_p.S677*|PDPR_ENST00000562100.1_3'UTR	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	777					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		GACCATGATTCAGACCTAGAC	0.547000													69	119					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35584003	35584003	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:35584003G>A	ENST00000287272.2	+	9	1450	c.1430G>A	c.(1429-1431)gGt>gAt	p.G477D	UNC5D_ENST00000453357.2_Missense_Mutation_p.G541D|UNC5D_ENST00000420357.1_Missense_Mutation_p.G479D|UNC5D_ENST00000416672.1_Missense_Mutation_p.G551D|UNC5D_ENST00000449677.1_Missense_Mutation_p.G122D|UNC5D_ENST00000404895.2_Missense_Mutation_p.G546D			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	546					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AGGACAACTGGTGTCTTTGGC	0.418000													7	130					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39969396	39969396	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:39969396C>T	ENST00000321562.4	+	1	214	c.110C>T	c.(109-111)gCc>gTc	p.A37V		NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	37					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		gccagcccggccgggggcccc	0.701000													12	34					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90333727	90333727	+	Silent	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:90333727C>G	ENST00000300060.6	-	20	3028	c.2715G>C	c.(2713-2715)gtG>gtC	p.V905V		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	905	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	ATCGTCGTGTCACTGCCTGGA	0.577000													4	37					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105418737	105418737	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:105418737G>T	ENST00000333244.5	-	7	3170	c.3051C>A	c.(3049-3051)atC>atA	p.I1017I	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1017						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCAAGGCCTTGATGGACTTCC	0.587000													9	319					3.86212e-05	4.15967e-05	1	1	0
JAK1	3716	broad.mit.edu	37	1	65301159	65301159	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:65301159C>A	ENST00000342505.4	-	24	3537	c.3289G>T	c.(3289-3291)Ggc>Tgc	p.G1097C		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	1097	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		GTCATCTGGCCATGGGTTGGG	0.403000			Mis		ALL								19	85					4.63292e-17	5.50964e-17	1	1	0
BCR	613	broad.mit.edu	37	22	23524036	23524036	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:23524036C>A	ENST00000305877.8	+	1	1640	c.889C>A	c.(889-891)Ctg>Atg	p.L297M	BCR_ENST00000398512.5_Missense_Mutation_p.L297M|BCR_ENST00000359540.3_Missense_Mutation_p.L297M	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	297	Binding to ABL SH2-domain.|Kinase.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						GGGCCCGCTCCTGCGCAGCCA	0.667000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								4	27					0.184627	0.185168	1	1	0
MGA	23269	broad.mit.edu	37	15	41988400	41988400	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:41988400G>T	ENST00000219905.7	+	3	1373	c.1192G>T	c.(1192-1194)Gaa>Taa	p.E398*	MGA_ENST00000570161.1_Nonsense_Mutation_p.E398*|MGA_ENST00000568630.1_3'UTR|MGA_ENST00000545763.1_Nonsense_Mutation_p.E398*|MGA_ENST00000389936.4_Nonsense_Mutation_p.E398*|MGA_ENST00000566586.1_Nonsense_Mutation_p.E398*	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	398						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TGAGTGCCCAGAAGGGGTCAC	0.443000													7	51					0.0477658	0.0482589	1	1	0
DYSF	8291	broad.mit.edu	37	2	71801376	71801376	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:71801376T>C	ENST00000258104.3	+	30	3500	c.3223T>C	c.(3223-3225)Ttt>Ctt	p.F1075L	DYSF_ENST00000409366.1_Missense_Mutation_p.F1076L|DYSF_ENST00000409744.1_Missense_Mutation_p.F1062L|DYSF_ENST00000429174.2_Missense_Mutation_p.F1075L|DYSF_ENST00000394120.2_Missense_Mutation_p.F1076L|DYSF_ENST00000410020.3_Missense_Mutation_p.F1093L|DYSF_ENST00000413539.2_Missense_Mutation_p.F1106L|DYSF_ENST00000409651.1_Missense_Mutation_p.F1107L|DYSF_ENST00000410041.1_Missense_Mutation_p.F1093L|DYSF_ENST00000409582.3_Missense_Mutation_p.F1092L|DYSF_ENST00000409762.1_Missense_Mutation_p.F1092L	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1075	Arg-rich.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CGCCTCTCTTTTTGGCTGGAA	0.672000													24	107					0	0	1	0	0
ARMC8	25852	broad.mit.edu	37	3	137956206	137956206	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:137956206T>C	ENST00000469044.1	+	8	936	c.665T>C	c.(664-666)gTa>gCa	p.V222A	ARMC8_ENST00000358441.2_Missense_Mutation_p.V208A|ARMC8_ENST00000393058.3_Missense_Mutation_p.V212A|ARMC8_ENST00000489213.1_Missense_Mutation_p.V180A|ARMC8_ENST00000481646.1_Missense_Mutation_p.V208A|ARMC8_ENST00000491704.1_Missense_Mutation_p.V180A|ARMC8_ENST00000538260.1_Missense_Mutation_p.V191A|ARMC8_ENST00000471453.1_Missense_Mutation_p.V208A|ARMC8_ENST00000470821.1_Missense_Mutation_p.V222A|ARMC8_ENST00000485396.1_Missense_Mutation_p.V149A|ARMC8_ENST00000461822.1_Missense_Mutation_p.V222A	NM_001267041.1|NM_001267042.1	NP_001253970.1|NP_001253971.1	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8	222							binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(5)|upper_aerodigestive_tract(1)	16						AACCCCCAGGTATCGATGACC	0.338000													6	100					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30358185	30358185	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:30358185G>C	ENST00000340513.4	+	6	924	c.396G>C	c.(394-396)caG>caC	p.Q132H	TPX2_ENST00000300403.6_Missense_Mutation_p.Q132H			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	132					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			ATTTGGAACAGAAAGAAAAGC	0.333000													15	31					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110383093	110383093	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:110383093G>T	ENST00000360185.4	-	15	1717	c.1553C>A	c.(1552-1554)tCc>tAc	p.S518Y	GIT2_ENST00000553118.1_Intron|GIT2_ENST00000457474.2_Intron|GIT2_ENST00000355312.3_Missense_Mutation_p.S568Y|GIT2_ENST00000338373.5_Missense_Mutation_p.S470Y|TCHP_ENST00000550780.1_Intron|GIT2_ENST00000356259.4_Intron|GIT2_ENST00000343646.5_Intron|GIT2_ENST00000551209.1_Missense_Mutation_p.S517Y|GIT2_ENST00000354574.4_Intron|GIT2_ENST00000361006.5_Intron	NM_014776.3	NP_055591.2	Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	568					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						CCTCGACCAGGAAAGTGTGGA	0.547000													4	30					0.014758	0.0150884	1	1	0
BMS1P20	96610	broad.mit.edu	37	22	22661272	22661272	+	RNA	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:22661272C>T	ENST00000426066.1	+	0	360					NR_027293.1																						CTGGGATGTACGTCTGCGTTG	0.488000													3	59					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579325	7579325	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:7579325G>T	ENST00000420246.2	-	4	494	c.362C>A	c.(361-363)tCt>tAt	p.S121Y	TP53_ENST00000413465.2_Missense_Mutation_p.S121Y|TP53_ENST00000269305.4_Missense_Mutation_p.S121Y|TP53_ENST00000445888.2_Missense_Mutation_p.S121Y|TP53_ENST00000455263.2_Missense_Mutation_p.S121Y|TP53_ENST00000359597.4_Missense_Mutation_p.S121Y	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	121	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		S -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.G59fs*23(3)|p.S121fs*27(1)|p.V73fs*9(1)|p.G105_T125del21(1)|p.G112_V122delGFLHSGTAKSV(1)|p.H115fs*27(1)|p.Y107fs*44(1)|p.S121fs*2(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.S121F(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAAGTCACAGACTTGGCTGT	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	36					3.57192e-18	4.25525e-18	1	1	0
GRIA2	2891	broad.mit.edu	37	4	158281151	158281151	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:158281151A>C	ENST00000296526.7	+	13	2472	c.2147A>C	c.(2146-2148)aAg>aCg	p.K716T	GRIA2_ENST00000507898.1_Missense_Mutation_p.K669T|GRIA2_ENST00000264426.9_Missense_Mutation_p.K716T|GRIA2_ENST00000449365.1_Missense_Mutation_p.K669T|GRIA2_ENST00000393815.2_Missense_Mutation_p.K669T	NM_000826.3	NP_000817	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	716					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AGAGTGCGGAAGTCCAAAGGG	0.493000													4	47					0	0	1	0	0
AHCY	191	broad.mit.edu	37	20	32878392	32878392	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:32878392G>A	ENST00000538132.1	-	7	1121	c.735C>T	c.(733-735)gtC>gtT	p.V245V	AHCY_ENST00000217426.2_Silent_p.V273V	NM_001161766.1	NP_001155238.1	P23526	SAHH_HUMAN	adenosylhomocysteinase	273					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding			endometrium(6)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						CTGTGGTGGTGACAAAGATGT	0.597000													6	136					0	0	1	0	0
TFEB	7942	broad.mit.edu	37	6	41652546	41652546	+	Missense_Mutation	SNP	C	C	T	rs148691652		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:41652546C>T	ENST00000230323.4	-	10	1523	c.1222G>A	c.(1222-1224)Gag>Aag	p.E408K	TFEB_ENST00000403298.4_Missense_Mutation_p.E408K|TFEB_ENST00000358871.2_Missense_Mutation_p.E422K|TFEB_ENST00000373033.1_Missense_Mutation_p.E408K|TFEB_ENST00000420312.1_Missense_Mutation_p.E323K	NM_001271945.1|NM_007162.2	NP_001258874.1|NP_009093.1	P19484	TFEB_HUMAN	transcription factor EB	408	Pro-rich.				embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	11	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GGGGGACCCTCGTCCTCCCTG	0.682000			T	ALPHA	renal (childhood epithelioid)								8	25					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207172283	207172283	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:207172283G>A	ENST00000374423.3	+	5	3417	c.3031G>A	c.(3031-3033)Gta>Ata	p.V1011I		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1011							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TCATTATTCAGTAACTGAACC	0.338000													8	39					0	0	1	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745833	77745833	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:77745833T>C	ENST00000409088.3	-	3	1576	c.1162A>G	c.(1162-1164)Acc>Gcc	p.T388A	LRRTM4_ENST00000409884.1_Missense_Mutation_p.T388A|LRRTM4_ENST00000409282.1_Missense_Mutation_p.T389A|LRRTM4_ENST00000409911.1_Missense_Mutation_p.T389A|LRRTM4_ENST00000409093.1_Missense_Mutation_p.T388A	NM_001282928.1|NM_024993.4	NP_001269857.1|NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	388						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		TTGAAGATGGTAGGTCTAGGG	0.483000													4	44					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44108963	44108963	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:44108963C>T	ENST00000262419.6	-	15	3667	c.3197G>A	c.(3196-3198)cGc>cAc	p.R1066H	KANSL1_ENST00000572904.1_Missense_Mutation_p.R1066H|KANSL1_ENST00000574590.1_Missense_Mutation_p.R1066H|KANSL1_ENST00000432791.1_Missense_Mutation_p.R1066H|KANSL1_ENST00000393476.3_Missense_Mutation_p.R360H|KANSL1_ENST00000575318.1_Missense_Mutation_p.R1002H	NM_001193466.1	NP_001180395	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	1066						MLL1 complex	protein binding	p.R1066L(1)									GCCTGAGGTGCGTCGAGTGCA	0.687000													4	28					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19175909	19175909	+	Missense_Mutation	SNP	C	C	T	rs143077243		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:19175909C>T	ENST00000375371.3	-	4	1414	c.1393G>A	c.(1393-1395)Gtc>Atc	p.V465I	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	465					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TAGGAGGCGACGCTCTGGAAG	0.602000													7	34					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105441885	105441885	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:105441885C>A	ENST00000351513.2	-	5	970	c.838G>T	c.(838-840)Gat>Tat	p.D280Y		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	280					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGAGTGCCATCTGTGCCAAGA	0.468000													7	85					2.0095e-06	2.22736e-06	1	1	0
ERBB2IP	55914	broad.mit.edu	37	5	65372200	65372200	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:65372200C>T	ENST00000284037.5	+	24	4409	c.4020C>T	c.(4018-4020)gtC>gtT	p.V1340V	ERBB2IP_ENST00000380939.2_Silent_p.V1288V|ERBB2IP_ENST00000380935.1_Silent_p.V1230V|ERBB2IP_ENST00000416865.2_Silent_p.V538V|ERBB2IP_ENST00000380936.1_Intron|ERBB2IP_ENST00000380938.2_Silent_p.V1299V|ERBB2IP_ENST00000508515.1_Silent_p.V1230V|ERBB2IP_ENST00000506030.1_Silent_p.V1347V|ERBB2IP_ENST00000380943.2_Silent_p.V1299V|ERBB2IP_ENST00000503913.1_3'UTR|ERBB2IP_ENST00000511297.1_Silent_p.V1295V	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	1340	PDZ.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		CAGGTGGTGTCGGGGGTAGAG	0.338000													3	71					0	0	1	0	0
FBXO47	494188	broad.mit.edu	37	17	37099048	37099048	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:37099048C>T	ENST00000378079.2	-	9	1265	c.1066G>A	c.(1066-1068)Gta>Ata	p.V356I		NM_001008777.2	NP_001008777.2	Q5MNV8	FBX47_HUMAN	F-box protein 47	356										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	20						AAAAAGACTACGAGCCTTGCC	0.403000													8	60					0	0	1	0	0
FBXO18	84893	broad.mit.edu	37	10	5951128	5951128	+	Silent	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:5951128A>G	ENST00000379999.5	+	6	1148	c.1044A>G	c.(1042-1044)acA>acG	p.T348T	FBXO18_ENST00000470089.1_3'UTR|FBXO18_ENST00000362091.4_Silent_p.T297T|FBXO18_ENST00000397269.3_5'UTR	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	297					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						ACAGATACACAGCCACCACTA	0.562000													14	42					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586533	20586533	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:20586533A>G	ENST00000315543.4	+	1	968	c.968A>G	c.(967-969)aAa>aGa	p.K323R		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CTGAGAAACAAAGAAATGAAG	0.378000													5	50					0	0	1	0	0
EFR3A	23167	broad.mit.edu	37	8	132991142	132991142	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:132991142T>G	ENST00000254624.5	+	13	1600	c.1375T>G	c.(1375-1377)Tct>Gct	p.S459A	EFR3A_ENST00000519656.1_Missense_Mutation_p.S423A|EFR3A_ENST00000334503.4_Missense_Mutation_p.S459A	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	459						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			ACTGCCAGGGTCTTTCCTGGA	0.418000													9	53					0	0	1	0	0
ECD	11319	broad.mit.edu	37	10	74897807	74897807	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:74897807G>C	ENST00000372979.4	-	12	1649	c.1443C>G	c.(1441-1443)atC>atG	p.I481M	ECD_ENST00000454759.2_Missense_Mutation_p.I438M|ECD_ENST00000430082.2_Missense_Mutation_p.I514M	NM_007265.2	NP_009196.1	O95905	SGT1_HUMAN	ecdysoneless homolog (Drosophila)	481					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(51;0.0119)					CATCAAAAGTGATTGGAGCCT	0.313000													7	28					0	0	1	0	0
GYS1	2997	broad.mit.edu	37	19	49489125	49489125	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:49489125G>C	ENST00000323798.3	-	4	856	c.660C>G	c.(658-660)ttC>ttG	p.F220L	GYS1_ENST00000541188.1_Missense_Mutation_p.F140L|GYS1_ENST00000540532.1_Missense_Mutation_p.F140L|GYS1_ENST00000263276.6_Missense_Mutation_p.F156L|GYS1_ENST00000544287.1_Intron	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	220					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		GGTTGTTGTAGAAGTCCACGG	0.632000													7	42					0	0	1	0	0
PLA2G4B	100137049	broad.mit.edu	37	15	42136730	42136730	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:42136730G>T	ENST00000542534.2	+	17	1674	c.1634G>T	c.(1633-1635)gGg>gTg	p.G545V	PLA2G4B_ENST00000452633.1_Missense_Mutation_p.G314V|JMJD7-PLA2G4B_ENST00000382448.4_Missense_Mutation_p.G545V|PLA2G4B_ENST00000458483.1_Missense_Mutation_p.G314V|JMJD7-PLA2G4B_ENST00000342159.4_Missense_Mutation_p.G545V	NM_005090.3	NP_005081.1			phospholipase A2, group IVB (cytosolic)														all_cancers(109;1.84e-13)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		all cancers(2;1.08e-30)|Epithelial(2;1.43e-22)|OV - Ovarian serous cystadenocarcinoma(18;1.13e-17)|GBM - Glioblastoma multiforme(94;9.77e-07)|Colorectal(2;0.0129)|COAD - Colon adenocarcinoma(120;0.0371)		TCCCTGTATGGGCAGCTGGCT	0.617000													23	103					2.89027e-11	3.35565e-11	1	1	0
SEC14L2	23541	broad.mit.edu	37	22	30803541	30803541	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:30803541G>A	ENST00000312932.9	+	5	632	c.372G>A	c.(370-372)aaG>aaA	p.K124K	SEC14L2_ENST00000402592.3_Intron|SEC14L2_ENST00000405717.3_Silent_p.K124K|SEC14L2_ENST00000403484.1_Silent_p.K50K|SEC14L2_ENST00000459728.1_3'UTR	NM_012429.3	NP_036561.1	O76054	S14L2_HUMAN	SEC14-like 2 (S. cerevisiae)	124	CRAL-TRIO.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	phospholipid binding|transporter activity|vitamin E binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|urinary_tract(1)	10					Vitamin E(DB00163)	TGAGGACCAAGATGCGGGAGT	0.547000													6	50					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209165	140209165	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:140209165C>T	ENST00000529310.1	+	1	1603	c.1489C>T	c.(1489-1491)Cgg>Tgg	p.R497W	PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.R497W|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018909.2|NM_031848.2|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGTGGAGCGGCGGGTGGG	0.672000													13	80					0	0	1	0	0
PAQR4	124222	broad.mit.edu	37	16	3021896	3021896	+	Missense_Mutation	SNP	G	G	A	rs142699591		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:3021896G>A	ENST00000318782.8	+	3	1199	c.769G>A	c.(769-771)Ggc>Agc	p.G257S	PAQR4_ENST00000293978.8_Missense_Mutation_p.G218S|PKMYT1_ENST00000431515.2_Intron|PAQR4_ENST00000576565.1_Missense_Mutation_p.G190S|PAQR4_ENST00000574988.1_Missense_Mutation_p.G190S|PAQR4_ENST00000572687.1_Missense_Mutation_p.G183S	NM_001284513.1|NM_152341.3	NP_001271442.1|NP_689554.2	Q8N4S7	PAQR4_HUMAN	progestin and adipoQ receptor family member IV	257						integral to membrane	receptor activity	p.G257L(1)		kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	8						GCTGCACGCCGGCGTCGTGCC	0.672000													5	28					0	0	1	0	0
SMR3B	10879	broad.mit.edu	37	4	71255388	71255388	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:71255388G>C	ENST00000304915.3	+	3	212	c.63G>C	c.(61-63)gaG>gaC	p.E21D	SMR3B_ENST00000504825.1_Missense_Mutation_p.E21D	NM_006685.3	NP_006676.1			submaxillary gland androgen regulated protein 3B											large_intestine(2)|lung(3)|skin(2)	7		all_hematologic(202;0.196)				AGCCTGGTGAGAGTCAAAGAG	0.468000													3	69					0	0	1	0	0
OR10G9	219870	broad.mit.edu	37	11	123894478	123894478	+	Silent	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:123894478C>A	ENST00000375024.1	+	1	759	c.759C>A	c.(757-759)ccC>ccA	p.P253P		NM_001001953.1	NP_001001953.1	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G, member 9	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(33)|prostate(2)|skin(4)|stomach(8)|urinary_tract(1)	61		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTTTTGTTCCCTGTGTTTTCA	0.537000													18	121					2.98393e-07	3.35631e-07	1	1	0
TGIF2LX	90316	broad.mit.edu	37	X	89177637	89177637	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:89177637G>A	ENST00000561129.2	+	1	683	c.553G>A	c.(553-555)Gga>Aga	p.G185R	TGIF2LX_ENST00000283891.5_Missense_Mutation_p.G185R			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	185						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						GAAGCTCACCGGAATAGCCCA	0.557000													6	15					0	0	1	0	0
ZNF699	374879	broad.mit.edu	37	19	9406292	9406292	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:9406292G>C	ENST00000591998.1	-	6	2016	c.1788C>G	c.(1786-1788)ttC>ttG	p.F596L	ZNF699_ENST00000308650.3_Missense_Mutation_p.F596L			Q32M78	ZN699_HUMAN	zinc finger protein 699	596					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGGGACAACTGAAAGCTTTTC	0.438000													14	58					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168067275	168067275	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:168067275G>A	ENST00000409195.1	+	4	682	c.593G>A	c.(592-594)gGa>gAa	p.G198E	XIRP2_ENST00000295237.9_Missense_Mutation_p.G198E|XIRP2_ENST00000409605.1_5'UTR|XIRP2_ENST00000409756.2_Missense_Mutation_p.G198E|XIRP2_ENST00000409043.1_Missense_Mutation_p.G198E|XIRP2_ENST00000409273.1_5'UTR|XIRP2_ENST00000409728.1_Missense_Mutation_p.G231E|XIRP2_ENST00000420519.1_Missense_Mutation_p.G231E	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	23					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CCTGAGAGTGGATTTGCAGAA	0.512000													29	135					0	0	1	0	0
SLC26A4	5172	broad.mit.edu	37	7	107355883	107355883	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:107355883G>C	ENST00000265715.3	+	21	2559	c.2335G>C	c.(2335-2337)Gca>Cca	p.A779P	SLC26A4_ENST00000541474.1_Missense_Mutation_p.A340P|SLC26A4_ENST00000543100.1_Missense_Mutation_p.A348P|SLC26A4_ENST00000544569.1_Missense_Mutation_p.A366P	NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	779					regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						GCGTACACTTGCATCCTGAAA	0.373000									Pendred syndrome				14	94					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113506789	113506789	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:113506789C>G	ENST00000505019.1	-	14	4134	c.4009G>C	c.(4009-4011)Gag>Cag	p.E1337Q		NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	0										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TTCAGTTTCTCTCCCTTCAAT	0.343000													3	34					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102446263	102446263	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:102446263T>C	ENST00000360184.4	+	4	890	c.726T>C	c.(724-726)ctT>ctC	p.L242L		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	242	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CAACATTTCTTAATCAGTTAC	0.348000													4	101					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47977622	47977622	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr21:47977622G>C	ENST00000318711.7	+	31	3940	c.3757G>C	c.(3757-3759)Gag>Cag	p.E1253Q	DIP2A_ENST00000400274.1_Missense_Mutation_p.E1248Q|DIP2A_ENST00000417564.2_Missense_Mutation_p.E1252Q	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	1252					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CTCTGTGATGGAGATGTGCAC	0.642000													7	36					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104079654	104079654	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:104079654G>A	ENST00000374874.3	+	7	1260	c.821G>A	c.(820-822)tGt>tAt	p.C274Y	LPPR1_ENST00000395056.2_Missense_Mutation_p.C274Y	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		274						integral to membrane	catalytic activity										CAGGGAATGTGTGTGGTTCAT	0.512000													7	122					0	0	1	0	0
CLPP	8192	broad.mit.edu	37	19	6361912	6361912	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:6361912G>A	ENST00000245816.4	+	2	354	c.231G>A	c.(229-231)tcG>tcA	p.S77S	CTB-180A7.3_ENST00000595644.1_RNA|CLPP_ENST00000596605.1_5'UTR|CLPP_ENST00000596149.1_5'UTR	NM_006012.2	NP_006003.1	Q16740	CLPP_HUMAN	caseinolytic mitochondrial matrix peptidase proteolytic subunit	77					proteolysis	mitochondrial matrix	ATP binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(2)|ovary(2)	6						ACATCTACTCGCGGCTGCTGC	0.731000													6	26					0	0	1	0	0
TCL1A	8115	broad.mit.edu	37	14	96180286	96180286	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:96180286C>T	ENST00000402399.1	-	1	247	c.118G>A	c.(118-120)Gag>Aag	p.E40K	RP11-164H13.1_ENST00000553445.1_RNA|TCL1A_ENST00000556450.1_Missense_Mutation_p.E40K|RP11-164H13.1_ENST00000547644.2_RNA|TCL1A_ENST00000555202.1_Missense_Mutation_p.E40K|TCL1A_ENST00000554012.1_Missense_Mutation_p.E40K	NM_021966.2	NP_068801.1	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	40					multicellular organismal development	endoplasmic reticulum|microsome				haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		GGCTGTACCTCGATGGTTAAG	0.632000			T	TRA@	T-CLL								11	50					0	0	1	0	0
COL8A2	1296	broad.mit.edu	37	1	36563218	36563218	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:36563218C>T	ENST00000397799.1	-	4	2288	c.2064G>A	c.(2062-2064)acG>acA	p.T688T	COL8A2_ENST00000303143.4_Silent_p.T688T|COL8A2_ENST00000481785.1_Silent_p.T623T			P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2	688	C1q.|Nonhelical region (NC1).				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			NS(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGATGTACTCCGTGGAGTAGA	0.647000													12	40					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197664327	197664327	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:197664327C>T	ENST00000263956.3	-	1	98	c.9G>A	c.(7-9)ggG>ggA	p.G3G	GTF3C3_ENST00000409364.3_Silent_p.G3G	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	3						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						CCGGACTGAACCCTGACATGT	0.557000													6	93					0	0	1	0	0
SYNGR2	9144	broad.mit.edu	37	17	76167066	76167066	+	Missense_Mutation	SNP	G	G	A	rs140124425		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:76167066G>A	ENST00000225777.3	+	2	327	c.268G>A	c.(268-270)Gcg>Acg	p.A90T	SYNGR2_ENST00000585591.1_Missense_Mutation_p.A90T|SYNGR2_ENST00000592456.1_3'UTR|SYNGR2_ENST00000589711.1_Intron|SYNGR2_ENST00000590201.1_Missense_Mutation_p.A34T|SYNGR2_ENST00000588282.1_Missense_Mutation_p.A90T			O43760	SNG2_HUMAN	synaptogyrin 2	90	MARVEL.					integral to plasma membrane				endometrium(2)|large_intestine(1)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	7			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			GGTGGTCGACGCGTATTTCCC	0.577000													16	56					0	0	1	0	0
FOXA3	3171	broad.mit.edu	37	19	46375625	46375625	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:46375625C>G	ENST00000302177.2	+	2	559	c.362C>G	c.(361-363)tCc>tGc	p.S121C		NM_004497.2	NP_004488.2	P55318	FOXA3_HUMAN	forkhead box A3	121					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	13		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		CCACCGTATTCCTATATCTCA	0.612000													6	71					0	0	1	0	0
MPPED1	758	broad.mit.edu	37	22	43821217	43821217	+	Splice_Site	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:43821217T>C	ENST00000417669.2	+	2	668		c.e2+2		MPPED1_ENST00000443721.1_Splice_Site|MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000414469.2_Intron|MPPED1_ENST00000542779.1_Splice_Site|MPPED1_ENST00000538182.1_Splice_Site			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1								hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				TGTGCAGATGTAAGTGGGACC	0.637000													4	26					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52643360	52643360	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:52643360C>T	ENST00000356770.4	-	15	2442	c.2440G>A	c.(2440-2442)Gaa>Aaa	p.E814K	PBRM1_ENST00000409114.3_Missense_Mutation_p.E861K|PBRM1_ENST00000409767.1_Missense_Mutation_p.E861K|PBRM1_ENST00000409057.1_Missense_Mutation_p.E846K|PBRM1_ENST00000394830.3_Missense_Mutation_p.E846K|PBRM1_ENST00000296302.7_Missense_Mutation_p.E846K|PBRM1_ENST00000337303.4_Missense_Mutation_p.E846K|PBRM1_ENST00000410007.1_Missense_Mutation_p.E846K			Q86U86	PB1_HUMAN	polybromo 1	846	Bromo 6.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.E846*(2)|p.E814*(1)		breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TCCAATACTTCAAACATATGC	0.328000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								5	66					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130331463	130331463	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:130331463C>T	ENST00000299164.2	+	2	1037	c.1037C>T	c.(1036-1038)tCt>tTt	p.S346F		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	346	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		AGAAGCTGCTCTGTCATTGAG	0.607000													6	88					0	0	1	0	0
PNN	5411	broad.mit.edu	37	14	39649941	39649941	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:39649941C>T	ENST00000216832.4	+	9	1095	c.1028C>T	c.(1027-1029)gCg>gTg	p.A343V	PNN_ENST00000557680.1_Intron	NM_002687.3	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	343	Glu-rich.			A -> G (in Ref. 1; AAB48304).	cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)|stomach(1)	27	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		aaggaaatagcgattgttcat	0.453000													4	12					0	0	1	0	0
NPS	594857	broad.mit.edu	37	10	129350727	129350727	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:129350727T>C	ENST00000398023.1	+	3	114	c.94T>C	c.(94-96)Tct>Cct	p.S32P		NM_001030013.1	NP_001025184.1	P0C0P6	NPS_HUMAN	neuropeptide S	32					neuropeptide signaling pathway	extracellular region				haematopoietic_and_lymphoid_tissue(1)|lung(4)	5						TTGCCAGGTGTCTGGAAAATC	0.388000													6	324					0	0	1	0	0
IMPA2	3613	broad.mit.edu	37	18	12028871	12028871	+	Silent	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:12028871A>G	ENST00000269159.3	+	7	872	c.630A>G	c.(628-630)gcA>gcG	p.A210A	IMPA2_ENST00000588927.1_Silent_p.A21A|IMPA2_ENST00000589238.1_Silent_p.A21A	NM_014214.2	NP_055029.1	O14732	IMPA2_HUMAN	inositol(myo)-1(or 4)-monophosphatase 2	210					inositol phosphate dephosphorylation|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|skin(2)|stomach(2)|urinary_tract(1)	12					Lithium(DB01356)	CCACATTGGCACTCTGCCACC	0.612000													8	101					0	0	1	0	0
ADNP2	22850	broad.mit.edu	37	18	77896105	77896105	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:77896105C>T	ENST00000262198.4	+	4	3264	c.2809C>T	c.(2809-2811)Cgc>Tgc	p.R937C		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	937					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R937C(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CCATTTGGTGCGCTGCAGAAG	0.557000													24	52					0	0	1	0	0
CTSL3P	392360	broad.mit.edu	37	9	90396120	90396120	+	RNA	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:90396120C>T	ENST00000354530.2	+	0	496					NR_027917.1																						tggggaatctcagcagagtcc	0.458000													5	47					0	0	1	0	0
IGHV1-18	28468	broad.mit.edu	37	14	106641659	106641659	+	RNA	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:106641659G>A	ENST00000390605.2	-	0	313																											TGGTGACTCTGCCCTGGAGCT	0.552000													37	196					0	0	1	0	0
PDE3B	5140	broad.mit.edu	37	11	14865508	14865508	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:14865508C>T	ENST00000282096.4	+	12	2809	c.2456C>T	c.(2455-2457)gCc>gTc	p.A819V	PDE3B_ENST00000455098.2_Missense_Mutation_p.A768V	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	819	Catalytic (By similarity).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GTGGCAGCTGCCATGCATGAT	0.408000													19	88					0	0	1	0	0
VPS37A	137492	broad.mit.edu	37	8	17143899	17143899	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:17143899C>T	ENST00000324849.4	+	11	1831	c.1157C>T	c.(1156-1158)gCg>gTg	p.A386V	VPS37A_ENST00000521829.1_Missense_Mutation_p.A361V	NM_001145152.1|NM_152415.2	NP_001138624.1|NP_689628.2	Q8NEZ2	VP37A_HUMAN	vacuolar protein sorting 37 homolog A (S. cerevisiae)	386	VPS37 C-terminal.				cellular membrane organization|endosome transport|protein transport	centrosome|late endosome membrane|nucleus				autonomic_ganglia(1)|breast(1)|kidney(2)|large_intestine(1)|lung(4)|skin(1)	10				Colorectal(111;0.0553)|COAD - Colon adenocarcinoma(73;0.212)		CTTCAGCAGGCGATAGCAATG	0.358000													5	23					0	0	1	0	0
SLC25A47	283600	broad.mit.edu	37	14	100795151	100795151	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:100795151C>T	ENST00000361529.3	+	5	494	c.416C>T	c.(415-417)tCg>tTg	p.S139L	SLC25A47_ENST00000557052.1_5'UTR	NM_207117.2	NP_997000.2	Q6Q0C1	S2547_HUMAN	solute carrier family 25, member 47	139					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	13						CTTTCGGCCTCGGGGCCGTTG	0.682000													7	37					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518193	113518193	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:113518193G>C	ENST00000284601.3	-	4	3022	c.2954C>G	c.(2953-2955)tCa>tGa	p.S985*		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	985					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TCTACTACCTGATGTCACTAT	0.368000													18	73					0	0	1	0	0
DHCR7	1717	broad.mit.edu	37	11	71146714	71146714	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:71146714C>T	ENST00000355527.3	-	9	1411	c.1135G>A	c.(1135-1137)Gag>Aag	p.E379K	DHCR7_ENST00000407721.2_Missense_Mutation_p.E379K	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	379					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	TAGGAGCACTCGATGACCTTG	0.647000									Smith-Lemli-Opitz syndrome				7	25					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160109736	160109736	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:160109736A>G	ENST00000361216.3	+	22	3085	c.2996A>G	c.(2995-2997)gAt>gGt	p.D999G	ATP1A2_ENST00000392233.3_Missense_Mutation_p.D988G	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	999					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TTCATCTATGATGAGGTCCGA	0.582000													27	120					0	0	1	0	0
WDR35	57539	broad.mit.edu	37	2	20130270	20130270	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:20130270G>C	ENST00000345530.3	-	26	3156	c.3041C>G	c.(3040-3042)tCt>tGt	p.S1014C	WDR35_ENST00000416055.2_Missense_Mutation_p.S487C|WDR35_ENST00000281405.4_Missense_Mutation_p.S1003C	NM_001006657.1	NP_001006658.1	Q9P2L0	WDR35_HUMAN	WD repeat domain 35	1014										breast(1)|endometrium(5)|kidney(8)|large_intestine(8)|lung(16)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCTGTTGTAGACAGAACTTC	0.493000													11	63					0	0	1	0	0
HIPK4	147746	broad.mit.edu	37	19	40890038	40890038	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:40890038G>A	ENST00000291823.2	-	2	758	c.474C>T	c.(472-474)gaC>gaT	p.D158D		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	158	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			CGGATCCGAAGTCAATCACCT	0.637000													11	43					0	0	1	0	0
SLC18A3	6572	broad.mit.edu	37	10	50820304	50820304	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:50820304C>T	ENST00000374115.3	+	1	1958	c.1518C>T	c.(1516-1518)ggC>ggT	p.G506G	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	506					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						CTGTGTCTGGCCAGGACGGCG	0.647000													6	78					0	0	1	0	0
OR6Q1	219952	broad.mit.edu	37	11	57798643	57798643	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:57798643C>G	ENST00000302622.3	+	1	242	c.219C>G	c.(217-219)atC>atG	p.I73M	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				GCCTTGAAATCTGGTACACTT	0.478000													32	137					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897037	175897037	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:175897037G>T	ENST00000359240.3	+	5	1031	c.361G>T	c.(361-363)Ggg>Tgg	p.G121W	ADAM29_ENST00000404450.4_Missense_Mutation_p.G121W|ADAM29_ENST00000514159.1_Missense_Mutation_p.G121W|ADAM29_ENST00000445694.1_Missense_Mutation_p.G121W	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	121					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TACCTGTTTTGGGGGTTTTCA	0.428000													9	95					0.00448238	0.00464513	1	1	0
UPF1	5976	broad.mit.edu	37	19	18968215	18968215	+	Silent	SNP	C	C	T	rs149225517		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:18968215C>T	ENST00000262803.5	+	15	2327	c.2055C>T	c.(2053-2055)ttC>ttT	p.F685F	UPF1_ENST00000599848.1_Silent_p.F696F	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	696					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						AGTCGCTCTTCGAGCGCCTGG	0.637000													8	47					0	0	1	0	0
LARP4B	23185	broad.mit.edu	37	10	909737	909737	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:909737C>T	ENST00000316157.3	-	4	416	c.376G>A	c.(376-378)Gct>Act	p.A126T		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	126							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						AGAGCGAGAGCGTTCATGTCT	0.522000													24	71					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30675470	30675470	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:30675470G>T	ENST00000376406.3	-	8	3533	c.2886C>A	c.(2884-2886)gcC>gcA	p.A962A	MDC1_ENST00000376405.2_Intron|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	962				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TTGGGCTGGAGGCCTGCCCTT	0.637000								Other conserved DNA damage response genes					11	55					2.80697e-09	3.22073e-09	1	1	0
DHX9	1660	broad.mit.edu	37	1	182827872	182827872	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:182827872A>G	ENST00000367549.3	+	10	1015	c.905A>G	c.(904-906)gAa>gGa	p.E302G		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	302	Interaction with BRCA1.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						TAATAGCCTGAAGATCCTTCT	0.413000													6	94					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111217049	111217049	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:111217049G>A	ENST00000369769.2	-	1	606	c.383C>T	c.(382-384)aCg>aTg	p.T128M		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	128						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCCAGCAGCGTCTCGGGGAA	0.662000													11	80					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79421055	79421055	+	Missense_Mutation	SNP	G	G	A	rs149692526	by1000genomes	TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:79421055G>A	ENST00000264895.6	+	61	9736	c.9296G>A	c.(9295-9297)cGa>cAa	p.R3099Q		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3094	Calx-beta 5.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CCAAAGAGCCGAGTCTTGAAG	0.478000													4	103					0	0	1	0	0
PSMB7	5695	broad.mit.edu	37	9	127119181	127119181	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:127119181T>C	ENST00000259457.3	-	7	597	c.584A>G	c.(583-585)aAg>aGg	p.K195R	PSMB7_ENST00000536392.1_3'UTR|PSMB7_ENST00000498485.1_5'UTR	NM_002799.3	NP_002790.1	Q99436	PSB7_HUMAN	proteasome (prosome, macropain) subunit, beta type, 7	195					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			breast(1)|endometrium(1)|kidney(1)|lung(1)|pancreas(1)	5						CACCAGATTCTTGGCTTCCTC	0.547000													9	65					0	0	1	0	0
SAMD8	142891	broad.mit.edu	37	10	76935909	76935909	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:76935909G>A	ENST00000372687.4	+	5	963	c.878G>A	c.(877-879)tGt>tAt	p.C293Y	SAMD8_ENST00000542569.1_Missense_Mutation_p.C293Y|SAMD8_ENST00000372690.3_Missense_Mutation_p.C356Y			Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8						sphingomyelin biosynthetic process	integral to membrane				NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	12	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GTTCACACATGTGGAGATTAC	0.413000													4	195					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57485051	57485051	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:57485051T>C	ENST00000371100.4	+	11	3366	c.2814T>C	c.(2812-2814)gaT>gaC	p.D938D	GNAS_ENST00000371095.3_Silent_p.D281D|GNAS_ENST00000313949.7_3'UTR|GNAS_ENST00000265620.7_Silent_p.D280D|GNAS_ENST00000371085.3_Silent_p.D295D|GNAS_ENST00000371075.3_3'UTR|GNAS_ENST00000306090.10_Silent_p.D281D|GNAS_ENST00000371102.4_Silent_p.D924D|GNAS_ENST00000354359.7_Silent_p.D296D|GNAS_ENST00000464624.2_3'UTR	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	295					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			ACAAGCAAGATCTGCTCGCTG	0.527000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			13	93					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18862967	18862967	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:18862967C>T	ENST00000317977.6	+	4	742	c.171C>T	c.(169-171)atC>atT	p.I57I	SLC5A10_ENST00000417251.2_Silent_p.I113I|SLC5A10_ENST00000395645.3_Silent_p.I113I|SLC5A10_ENST00000395642.1_Silent_p.I57I|SLC5A10_ENST00000395647.2_Silent_p.I113I|SLC5A10_ENST00000395643.2_Silent_p.I113I	NM_001282417.1	NP_001269346.1	A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	113					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						CCATCTACATCTCCTCAGAGG	0.607000													6	25					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9871715	9871715	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:9871715C>T	ENST00000256190.8	-	22	2798	c.2661G>A	c.(2659-2661)gaG>gaA	p.E887E	RP11-1H15.2_ENST00000533659.1_RNA	NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	887	GRAM.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CTCGAAGACCCTCACAGACAA	0.463000													17	70					0	0	1	0	0
KIF5B	3799	broad.mit.edu	37	10	32323666	32323666	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:32323666G>A	ENST00000302418.4	-	11	1520	c.1063C>T	c.(1063-1065)Cgg>Tgg	p.R355W		NM_004521.2	NP_004512.1	P33176	KINH_HUMAN	kinesin family member 5B	355					stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				ATAGTGTTCCGCAGGATCTTA	0.343000			T	"""RET, ALK"""	NSCLC								5	63					0	0	1	0	0
CA6	765	broad.mit.edu	37	1	9009441	9009441	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:9009441A>G	ENST00000480186.3	+	2	204	c.199A>G	c.(199-201)Aat>Gat	p.N67D	CA6_ENST00000377443.2_Missense_Mutation_p.N67D|CA6_ENST00000476083.1_Intron|CA6_ENST00000377436.3_Missense_Mutation_p.N67D|CA6_ENST00000377442.2_Intron			P23280	CAH6_HUMAN	carbonic anhydrase VI						one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(5)	16	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGGGGCTCAATATGACAGG	0.602000													6	27					0	0	1	0	0
NPTN	27020	broad.mit.edu	37	15	73889661	73889661	+	Silent	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:73889661G>T	ENST00000345330.4	-	2	338	c.141C>A	c.(139-141)gcC>gcA	p.A47A	NPTN_ENST00000287226.8_Silent_p.A47A|NPTN_ENST00000562924.1_Intron|NPTN_ENST00000564551.1_Intron|NPTN_ENST00000563691.1_Silent_p.A47A|NPTN_ENST00000351217.6_Intron|NPTN_ENST00000545878.1_Silent_p.A47A|NPTN_ENST00000542234.1_Intron	NM_001161363.1|NM_012428.3	NP_001154835.1|NP_036560.1	Q9Y639	NPTN_HUMAN	neuroplastin	47	Ig-like 1.				elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	13						ACAGCTCAAAGGCGTCCCCCG	0.562000													6	43					0.0215528	0.0220024	1	1	0
GPRC6A	222545	broad.mit.edu	37	6	117130529	117130529	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:117130529G>C	ENST00000310357.3	-	2	467	c.446C>G	c.(445-447)tCa>tGa	p.S149*	GPRC6A_ENST00000530250.1_Nonsense_Mutation_p.S149*|GPRC6A_ENST00000368549.3_Nonsense_Mutation_p.S149*	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	149					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AGTTATTTCTGAGTACCCAGA	0.403000													17	79					0	0	1	0	0
CYB561D2	11068	broad.mit.edu	37	3	50391063	50391063	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:50391063C>A	ENST00000418577.1	+	3	1133	c.557C>A	c.(556-558)tCt>tAt	p.S186Y	CYB561D2_ENST00000424512.1_Missense_Mutation_p.S186Y|XXcos-LUCA11.5_ENST00000606589.1_Intron|CYB561D2_ENST00000232508.5_Missense_Mutation_p.S186Y|CYB561D2_ENST00000425346.1_Missense_Mutation_p.S186Y			O14569	C56D2_HUMAN	cytochrome b561 family, member D2	186	Cytochrome b561.				electron transport chain|transport	integral to membrane	metal ion binding			endometrium(1)|lung(1)|urinary_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TTCACTGCCTCTGTCACTGGT	0.557000													30	120					5.91797e-21	7.07471e-21	1	1	0
CRAMP1L	57585	broad.mit.edu	37	16	1691168	1691168	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:1691168G>C	ENST00000454337.1	+	3	220	c.220G>C	c.(220-222)Gaa>Caa	p.E74Q	CRAMP1L_ENST00000397412.3_Silent_p.L269L|CRAMP1L_ENST00000293925.5_Silent_p.L269L|CRAMP1L_ENST00000436138.3_Silent_p.L266L																							CAACAAAGCTGAATGAACTCA	0.368000													15	66					0	0	1	0	0
EEF1D	1936	broad.mit.edu	37	8	144671271	144671271	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:144671271G>A	ENST00000532741.1	-	1	1359	c.1131C>T	c.(1129-1131)tgC>tgT	p.C377C	EEF1D_ENST00000442189.2_Silent_p.C327C|EEF1D_ENST00000528610.1_Intron|EEF1D_ENST00000526838.1_Intron|EEF1D_ENST00000529272.1_Intron|EEF1D_ENST00000419152.2_Intron|EEF1D_ENST00000395119.3_Intron|EEF1D_ENST00000423316.2_Silent_p.C327C|EEF1D_ENST00000531621.1_Intron|EEF1D_ENST00000317198.6_Intron|EEF1D_ENST00000532400.1_Intron|EEF1D_ENST00000524624.1_Intron			P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	0					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			breast(2)|cervix(1)|endometrium(1)|kidney(4)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CGTGGTGGCGGCACTCGGCGC	0.692000													3	8					0	0	1	0	0
HGS	9146	broad.mit.edu	37	17	79655766	79655766	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:79655766C>G	ENST00000329138.4	+	5	459	c.324C>G	c.(322-324)atC>atG	p.I108M		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	108	VHS.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			GTAACAAGATCCTGTACCTGA	0.597000													11	14					0	0	1	0	0
AGO2	27161	broad.mit.edu	37	8	141559307	141559307	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:141559307C>T	ENST00000220592.5	-	12	1606	c.1494G>A	c.(1492-1494)gcG>gcA	p.A498A	AGO2_ENST00000519980.1_Silent_p.A498A	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		CCACGCTGTCCGCCCCCTGCG	0.632000													5	34					0	0	1	0	0
ZNF816	125893	broad.mit.edu	37	19	53453802	53453802	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:53453802C>G	ENST00000357666.4	-	5	1526	c.1226G>C	c.(1225-1227)aGa>aCa	p.R409T	ZNF321P_ENST00000391777.3_Intron|ZNF816_ENST00000434371.2_Intron|ZNF816_ENST00000444460.2_Missense_Mutation_p.R409T	NM_001031665.2	NP_001026835.1	Q0VGE8	ZN816_HUMAN	zinc finger protein 816	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(10)|lung(9)|stomach(1)|urinary_tract(2)	27						AAGGTGTGATCTGCGAATGTA	0.393000													12	127					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158902258	158902258	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:158902258C>T	ENST00000367097.3	+	8	2780	c.1423C>T	c.(1423-1425)Cgg>Tgg	p.R475W	TULP4_ENST00000367094.2_Missense_Mutation_p.R475W	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	475					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CCTCAAAGGGCGGCGCATCAG	0.647000													7	30					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22186673	22186673	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:22186673C>G	ENST00000374695.3	-	40	5090	c.5011G>C	c.(5011-5013)Gag>Cag	p.E1671Q		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1671					angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CACTTACTCTCTGGCAGGCAC	0.647000													5	18					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94983445	94983445	+	Missense_Mutation	SNP	T	T	C	rs34897570		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:94983445T>C	ENST00000357742.4	+	17	2126	c.2126T>C	c.(2125-2127)aTc>aCc	p.I709T	MCTP2_ENST00000451018.3_Intron	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	709					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CTATATATGATCCCCTTGGCA	0.413000													26	125					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24923171	24923171	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:24923171G>T	ENST00000329468.2	+	1	2631	c.2157G>T	c.(2155-2157)aaG>aaT	p.K719N		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TCTCCAAGAAGTACCTCCCAT	0.527000													15	100					1.49906e-05	1.64034e-05	1	1	0
KIAA0947	23379	broad.mit.edu	37	5	5462936	5462936	+	Silent	SNP	T	T	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:5462936T>C	ENST00000296564.7	+	13	3711	c.3489T>C	c.(3487-3489)acT>acC	p.T1163T		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	1163										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						ACATAAGTACTTTTTCTGAGC	0.418000													3	15					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86198906	86198906	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:86198906C>A	ENST00000394518.2	+	11	4728	c.4633C>A	c.(4633-4635)Cct>Act	p.P1545T	AKAP13_ENST00000361243.2_Missense_Mutation_p.P1545T|AKAP13_ENST00000560579.1_3'UTR|RP11-815J21.4_ENST00000558980.1_RNA	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1545					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						CACTGAAGTGCCTGCAAACTG	0.577000													11	47					3.86212e-05	4.15967e-05	1	1	0
ZNF567	163081	broad.mit.edu	37	19	37211037	37211037	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:37211037C>T	ENST00000585696.1	+	3	2548	c.1318C>T	c.(1318-1320)Cat>Tat	p.H440Y	ZNF567_ENST00000588311.1_Missense_Mutation_p.H440Y|ZNF567_ENST00000536254.2_Missense_Mutation_p.H471Y|ZNF567_ENST00000360729.4_Missense_Mutation_p.H440Y|ZNF567_ENST00000392163.2_Missense_Mutation_p.H440Y|ZNF850_ENST00000589390.1_Intron			Q8N184	ZN567_HUMAN	zinc finger protein 567	471					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TCAGAGAACACATACAGGGGA	0.428000													14	84					0	0	1	0	0
TBX5	6910	broad.mit.edu	37	12	114832653	114832653	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:114832653C>T	ENST00000310346.4	-	6	1222	c.556G>A	c.(556-558)Gtg>Atg	p.V186M	TBX5_ENST00000349716.5_Missense_Mutation_p.V136M|TBX5_ENST00000526441.1_Missense_Mutation_p.V186M|TBX5_ENST00000405440.2_Missense_Mutation_p.V186M	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	186					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TCCGCTTTCACGATGTGTAAT	0.363000													36	157					0	0	1	0	0
DHRS11	79154	broad.mit.edu	37	17	34951594	34951594	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:34951594G>A	ENST00000251312.5	+	2	553	c.341G>A	c.(340-342)tGg>tAg	p.W114*	DHRS11_ENST00000590554.1_Nonsense_Mutation_p.W35*|DHRS11_ENST00000394445.1_3'UTR	NM_024308.3	NP_077284.2	Q6UWP2	DHR11_HUMAN	dehydrogenase/reductase (SDR family) member 11	114						extracellular region	binding|oxidoreductase activity			endometrium(1)|lung(4)	5						ACCAGTGGTTGGAAGGACATG	0.572000													3	34					0	0	1	0	0
ZNF200	7752	broad.mit.edu	37	16	3282457	3282457	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:3282457C>T	ENST00000431561.3	-	4	1042	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	ZNF200_ENST00000414144.2_Missense_Mutation_p.E144K|ZNF200_ENST00000396871.4_Missense_Mutation_p.E144K|ZNF200_ENST00000396870.4_Missense_Mutation_p.E144K|ZNF200_ENST00000396868.3_Missense_Mutation_p.E143K|ZNF200_ENST00000575948.1_Missense_Mutation_p.E144K	NM_001145447.1|NM_003454.3	NP_001138919.1|NP_003445.2	P98182	ZN200_HUMAN	zinc finger protein 200	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	17						CTGTCATCTTCCTTCTCTGAC	0.453000													23	124					0	0	1	0	0
DLL1	28514	broad.mit.edu	37	6	170592091	170592091	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:170592091G>A	ENST00000366756.3	-	10	2484	c.2151C>T	c.(2149-2151)tgC>tgT	p.C717C		NM_005618.3	NP_005609.3	O00548	DLL1_HUMAN	delta-like 1 (Drosophila)	717					cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			NS(2)|breast(1)|endometrium(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	33		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		TTGCTATGACGCACTCATCCT	0.552000													17	112					0	0	1	0	0
AMHR2	269	broad.mit.edu	37	12	53819354	53819354	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:53819354C>T	ENST00000257863.4	+	5	698	c.618C>T	c.(616-618)tcC>tcT	p.S206S	AMHR2_ENST00000550311.1_Silent_p.S206S|AMHR2_ENST00000379791.3_Silent_p.S206S	NM_001164690.1|NM_020547.2	NP_001158162.1|NP_065434.1	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II	206	Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding	p.S206S(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|skin(2)	34					Adenosine triphosphate(DB00171)	TGTGTTTCTCCCAGGTGCCCC	0.617000													3	30					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2760755	2760755	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:2760755C>T	ENST00000344100.3	+	32	3961	c.3961C>T	c.(3961-3963)Cac>Tac	p.H1321Y	CACNA1C_ENST00000399655.1_Intron|CACNA1C_ENST00000399644.1_Intron|CACNA1C_ENST00000399603.1_Intron|CACNA1C_ENST00000327702.7_Intron|CACNA1C_ENST00000399637.1_Intron|CACNA1C_ENST00000399621.1_Intron|CACNA1C_ENST00000399617.1_Intron|CACNA1C_ENST00000399649.1_Intron|CACNA1C_ENST00000399634.1_Intron|CACNA1C_ENST00000402845.3_Intron|CACNA1C_ENST00000399641.1_Intron|CACNA1C_ENST00000347598.4_Intron|CACNA1C_ENST00000399597.1_Intron|CACNA1C_ENST00000399638.1_Intron|CACNA1C_ENST00000335762.5_Intron|CACNA1C_ENST00000406454.3_Intron|CACNA1C_ENST00000399595.1_Intron|CACNA1C_ENST00000399591.1_Intron|CACNA1C_ENST00000399629.1_Intron|CACNA1C_ENST00000399606.1_Intron|CACNA1C_ENST00000399601.1_Intron			Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1363					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CTCCTGTTCTCACCCCCCTCT	0.612000													11	43					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23186033	23186033	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:23186033G>A	ENST00000389131.3	-	6	1381	c.1012C>T	c.(1012-1014)Cgc>Tgc	p.R338C		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	338	SRCR 3.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		ACCTCCACGCGGCCCTCCCCG	0.622000													17	39					0	0	1	0	0
CRTC3	64784	broad.mit.edu	37	15	91172566	91172566	+	Silent	SNP	C	C	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:91172566C>T	ENST00000420329.2	+	11	1215	c.1068C>T	c.(1066-1068)aaC>aaT	p.N356N	RP11-387D10.2_ENST00000559531.1_RNA|CRTC3_ENST00000268184.6_Silent_p.N356N	NM_001042574.2|NM_022769.4	NP_001036039.1|NP_073606.3	Q6UUV7	CRTC3_HUMAN	CREB regulated transcription coactivator 3	356					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	breast(1)|endometrium(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CTGTTCCCAACGCATCTGCTC	0.552000			T	MAML2	salivary gland mucoepidermoid								5	154					0	0	1	0	0
VEZT	55591	broad.mit.edu	37	12	95694441	95694441	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:95694441G>A	ENST00000436874.1	+	12	2437	c.2332G>A	c.(2332-2334)Gaa>Aaa	p.E778K	VEZT_ENST00000356859.4_3'UTR|VEZT_ENST00000261219.6_Missense_Mutation_p.E730K	NM_017599.3	NP_060069.3	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane protein	778						acrosomal vesicle|adherens junction|integral to membrane|nucleus				endometrium(2)|kidney(3)|large_intestine(1)|lung(14)|ovary(2)|upper_aerodigestive_tract(1)	23						TGAGATAGAAGAAAAGTAAGA	0.353000													4	16					0	0	1	0	0
HGS	9146	broad.mit.edu	37	17	79662979	79662979	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:79662979G>A	ENST00000329138.4	+	15	1478	c.1343G>A	c.(1342-1344)gGc>gAc	p.G448D		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	448	Interaction with SNAP25 and TRAK2 (By similarity).|Interaction with SNX1 (By similarity).				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			TCCATCAACGGCATGCACCCG	0.652000													3	29					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62713149	62713149	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:62713149C>G	ENST00000371153.4	-	9	3256	c.2878G>C	c.(2878-2880)Gac>Cac	p.D960H	KANK4_ENST00000354381.3_Missense_Mutation_p.D332H|KANK4_ENST00000371150.1_Missense_Mutation_p.D316H|KANK4_ENST00000317477.4_Missense_Mutation_p.D98H	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	960										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						CTCACCTTGTCAGTCAGGCTG	0.602000													3	47					0	0	1	0	0
TIGD7	91151	broad.mit.edu	37	16	3349228	3349228	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:3349228G>T	ENST00000396862.1	-	2	3215	c.1387C>A	c.(1387-1389)Caa>Aaa	p.Q463K	TIGD7_ENST00000268674.2_Missense_Mutation_p.Q463K	NM_033208.3	NP_149985.2	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	463					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						CCTCCTTTTTGAACAACTTCC	0.398000													5	161					0.0293803	0.0298156	1	1	0
SHKBP1	92799	broad.mit.edu	37	19	41083167	41083167	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:41083167G>A	ENST00000291842.5	+	2	166	c.117G>A	c.(115-117)tgG>tgA	p.W39*	SHKBP1_ENST00000600733.1_Nonsense_Mutation_p.W39*	NM_138392.3	NP_612401.2	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	39	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(3)|urinary_tract(1)	29			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTCTCACCTGGATCCCAGACT	0.612000													8	45					0	0	1	0	0
IL20RA	53832	broad.mit.edu	37	6	137323065	137323065	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:137323065A>G	ENST00000367748.1	-	6	1545	c.959T>C	c.(958-960)tTa>tCa	p.L320S	IL20RA_ENST00000316649.5_Missense_Mutation_p.L431S|IL20RA_ENST00000541547.1_Missense_Mutation_p.L382S	NM_001278723.1	NP_001265652.1	Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha	431						integral to membrane	receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)		CGACTCCAATAATGTTCCTTG	0.532000													3	61					0	0	1	0	0
PRAM1	84106	broad.mit.edu	37	19	8564305	8564305	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:8564305C>A	ENST00000423345.4	-	2	907	c.387G>T	c.(385-387)aaG>aaT	p.K129N	PRAM1_ENST00000255612.3_Missense_Mutation_p.K129N			Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	177	8 X 12 AA repeats of K-P-P-[PQ]-P-[EQ]- [VAF]-T-D-L-P-K.|Pro-rich.						lipid binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)	19						GTGGGAACTTCTTGGAGAGGT	0.652000													15	65					1.02788e-11	1.19949e-11	1	1	0
OTUD7B	56957	broad.mit.edu	37	1	149916332	149916332	+	Silent	SNP	G	G	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:149916332G>A	ENST00000369135.4	-	12	2250	c.1956C>T	c.(1954-1956)atC>atT	p.I652I		NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B						negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			CTCCATTCATGATCTTCCTCT	0.562000													5	75					0	0	1	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202418189	202418189	+	Silent	SNP	C	C	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:202418189C>G	ENST00000608999.1	+	13	1893	c.1740C>G	c.(1738-1740)ctC>ctG	p.L580L	PPP1R12B_ENST00000336894.4_Silent_p.L580L	NM_001197131.1|NM_002481.3	NP_001184060.1|NP_002472.2	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory subunit 12B						regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(17)|ovary(4)|skin(3)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(75;0.166)			GCACCCCGCTCTGTGTGATCA	0.493000													4	50					0	0	1	0	0
HP1BP3	50809	broad.mit.edu	37	1	21100060	21100060	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:21100060delT	ENST00000312239.5	-	5	533	c.394delA	c.(394-396)acafs	p.T132fs	HP1BP3_ENST00000375003.2_5'UTR	NM_016287.3	NP_057371.2	Q5SSJ5	HP1B3_HUMAN	heterochromatin protein 1, binding protein 3	132					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(2)|skin(2)|urinary_tract(1)	16		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		GAAGGAATTGTTTTTTTCACT	0.413													7	41	---	---	---	---					
SH3BGRL3	83442	broad.mit.edu	37	1	26606675	26606675	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:26606675delC	ENST00000270792.5	+	1	1009	c.29delC	c.(28-30)tcgfs	p.S10fs	SH3BGRL3_ENST00000319041.6_Frame_Shift_Del_p.S10fs	NM_031286.3	NP_112576.1	Q9H299	SH3L3_HUMAN	SH3 domain binding glutamic acid-rich protein like 3	10	Glutaredoxin.				cell redox homeostasis	cytoplasm|nucleus	electron carrier activity|protein disulfide oxidoreductase activity						all_cancers(24;1.16e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.22e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00751)|READ - Rectum adenocarcinoma(331;0.0649)		TACAGCACGTCGGTCACCGGC	0.721													2	4	---	---	---	---					
THRAP3	9967	broad.mit.edu	37	1	36762331	36762332	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:36762331_36762332insA	ENST00000354618.5	+	9	2487_2488	c.2263_2264insA	c.(2263-2265)gaafs	p.E755fs	THRAP3_ENST00000469141.2_Frame_Shift_Ins_p.E755fs	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	755					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AAGGTCAGCTGAAAAAACAGAG	0.431			T	USP6	aneurysmal bone cysts								9	46	---	---	---	---					
PTCH2	8643	broad.mit.edu	37	1	45292664	45292664	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:45292664delG	ENST00000447098.2	-	17	2616	c.2605delC	c.(2605-2607)ctgfs	p.L869fs	PTCH2_ENST00000372192.3_Frame_Shift_Del_p.L869fs	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	869					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					GCCAGACCCAGGGGGTCACTG	0.602									Basal Cell Nevus syndrome				30	195	---	---	---	---					
ST6GALNAC3	256435	broad.mit.edu	37	1	77094396	77094396	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:77094396delG	ENST00000328299.3	+	5	971	c.823delG	c.(823-825)gggfs	p.G276fs		NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	276					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						TGCCCCATATGGGGGTCATAG	0.378													8	75	---	---	---	---					
ELTD1	64123	broad.mit.edu	37	1	79385987	79385988	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:79385987_79385988insA	ENST00000370742.3	-	10	1404_1405	c.1341_1342insT	c.(1339-1344)tttaccfs	p.T448fs		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	448					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		AACCAGAAGGTAAAAATGCATA	0.322													20	86	---	---	---	---					
CCDC18	343099	broad.mit.edu	37	1	93683367	93683368	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:93683367_93683368insA	ENST00000343253.7	+	14	2402_2403	c.1900_1901insA	c.(1900-1902)gaafs	p.E634fs	CCDC18_ENST00000557479.1_Frame_Shift_Ins_p.E753fs|CCDC18_ENST00000338949.4_Intron|CCDC18_ENST00000401026.3_Frame_Shift_Ins_p.E635fs|CCDC18_ENST00000334652.5_5'UTR			Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18	634										breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TTTAGCCTTTGAAAAAGCAAAG	0.297													11	86	---	---	---	---					
PIAS3	10401	broad.mit.edu	37	1	145585532	145585533	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:145585532_145585533insG	ENST00000393045.2	+	14	1887_1888	c.1797_1798insG	c.(1798-1800)gggfs	p.G600fs	PIAS3_ENST00000369298.1_Frame_Shift_Ins_p.G565fs	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	600					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTGTGGCCCCTGGGGGGGCCTT	0.663													8	59	---	---	---	---					
DYRK3	8444	broad.mit.edu	37	1	206821938	206821938	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:206821938delG	ENST00000367106.1	+	4	1808	c.1335delG	c.(1333-1335)gtgfs	p.V445fs	DYRK3_ENST00000367108.3_Frame_Shift_Del_p.V445fs|DYRK3_ENST00000489878.1_Intron|DYRK3_ENST00000367109.2_Frame_Shift_Del_p.V465fs			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	465	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.V430V(1)|p.V465V(1)		central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			TTGTGCTTGTGGGGGGTCGCT	0.527													33	178	---	---	---	---					
PLXNA2	5362	broad.mit.edu	37	1	208391176	208391176	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:208391176delG	ENST00000367033.3	-	2	849	c.92delC	c.(91-93)ccafs	p.P31fs		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	31					axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GCCGGCTGCTGGGGGGGCCAG	0.652													9	75	---	---	---	---					
PARP1	142	broad.mit.edu	37	1	226576366	226576366	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:226576366delT	ENST00000366794.5	-	5	851	c.708delA	c.(706-708)aaafs	p.K236fs		NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	236					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		CCTTTAGGGCTTTTTCAAGCT	0.428								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					10	61	---	---	---	---					
CDC42BPA	8476	broad.mit.edu	37	1	227300483	227300483	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:227300483delT	ENST00000366769.3	-	13	3070	c.1779delA	c.(1777-1779)aaafs	p.K593fs	CDC42BPA_ENST00000366765.3_Frame_Shift_Del_p.K593fs|CDC42BPA_ENST00000535525.1_Frame_Shift_Del_p.K593fs|CDC42BPA_ENST00000334218.5_Frame_Shift_Del_p.K593fs|CDC42BPA_ENST00000366767.3_Intron|CDC42BPA_ENST00000366766.2_Frame_Shift_Del_p.K593fs|CDC42BPA_ENST00000366764.2_Frame_Shift_Del_p.K593fs	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	593					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				CAAGTTTCTGTTTTTGGGTGT	0.468													10	236	---	---	---	---					
SMYD3	64754	broad.mit.edu	37	1	246490502	246490503	+	Splice_Site	INS	-	-	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr1:246490502_246490503insT	ENST00000490107.1	-	5	570_571		c.e5+1		SMYD3_ENST00000403792.3_Splice_Site|SMYD3_ENST00000541742.1_Splice_Site|SMYD3_ENST00000388985.4_Splice_Site	NM_001167740.1	NP_001161212.1	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3							cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			breast(3)|large_intestine(5)|lung(8)|skin(1)	17	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		TTAACACTTACTTTTGCAAAGG	0.376													22	71	---	---	---	---					
MSH6	2956	broad.mit.edu	37	2	48026207	48026209	+	In_Frame_Del	DEL	CTA	CTA	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:48026207_48026209delCTA	ENST00000234420.5	+	4	1237_1239	c.1085_1087delCTA	c.(1084-1089)cctact>cct	p.T363del	MSH6_ENST00000540021.1_In_Frame_Del_p.T233del|FBXO11_ENST00000405808.1_Intron|MSH6_ENST00000538136.1_In_Frame_Del_p.T61del	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6						determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGTAGTCGCCCTACTGTTTGGTA	0.448			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				13	79	---	---	---	---					
H3F3AP4	440926	broad.mit.edu	37	2	175585079	175585079	+	RNA	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr2:175585079delA	ENST00000442996.1	+	0	217																											TTTCATTCTCAAAAAAAAAAA	0.368											OREG0015078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	5	---	---	---	---					
OR5K4	403278	broad.mit.edu	37	3	98072930	98072930	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:98072930delC	ENST00000354924.2	+	1	233	c.233delC	c.(232-234)accfs	p.T78fs	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005517.1	NP_001005517.1	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K, member 4	78					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	21						TGTGCTGTTACCCCCAAGATG	0.418													88	287	---	---	---	---					
LINC00882	100302640	broad.mit.edu	37	3	106825051	106825051	+	RNA	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:106825051delT	ENST00000484698.1	-	0	295																											TTCGACCCTCTTTTTGGCTGT	0.473													9	88	---	---	---	---					
CCDC80	151887	broad.mit.edu	37	3	112335584	112335584	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:112335584delT	ENST00000206423.3	-	5	3247	c.2294delA	c.(2293-2295)aagfs	p.K765fs	CCDC80_ENST00000439685.2_Frame_Shift_Del_p.K765fs	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	765										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						CAGGGACTGCTTTTTGTCCTC	0.433													12	89	---	---	---	---					
P2RY12	64805	broad.mit.edu	37	3	151056522	151056523	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:151056522_151056523insA	ENST00000302632.3	-	3	410_411	c.111_112insT	c.(109-114)tttgttfs	p.V38fs	MED12L_ENST00000474524.1_Intron|MED12L_ENST00000491549.1_Intron|MED12L_ENST00000273432.4_Intron	NM_022788.4|NM_176876.2	NP_073625.1|NP_795345.1	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y, G-protein coupled, 12	38					platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	17			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)	ATAAGTCCAACAAAAAACAGGA	0.431													11	64	---	---	---	---					
EHHADH	1962	broad.mit.edu	37	3	184910529	184910529	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr3:184910529delT	ENST00000231887.3	-	7	1732	c.1657delA	c.(1657-1659)aggfs	p.R553fs	EHHADH_ENST00000456310.1_Frame_Shift_Del_p.R457fs	NM_001166415.1|NM_001966.3	NP_001159887.1|NP_001957.2	Q08426	ECHP_HUMAN	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	553	3-hydroxyacyl-CoA dehydrogenase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(2)|skin(3)	24	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	CTATTACCCCTTTTTCGGGCA	0.478													16	82	---	---	---	---					
WDFY3	23001	broad.mit.edu	37	4	85676452	85676453	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:85676452_85676453insA	ENST00000322366.6	-	34	5932_5933	c.5525_5526insT	c.(5524-5526)ttafs	p.L1842fs	WDFY3_ENST00000295888.4_Frame_Shift_Ins_p.L1842fs			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1842						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTCCCAATAATAAAAAAACAGC	0.421													11	64	---	---	---	---					
LARP7	51574	broad.mit.edu	37	4	113570754	113570754	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:113570754delA	ENST00000509061.1	+	11	1530	c.1227delA	c.(1225-1227)ttafs	p.L409fs	LARP7_ENST00000344442.5_Frame_Shift_Del_p.L402fs|MIR302B_ENST00000510655.1_RNA|LARP7_ENST00000324052.6_Frame_Shift_Del_p.L402fs	NM_001267039.1	NP_001253968.1	Q4G0J3	LARP7_HUMAN	La ribonucleoprotein domain family, member 7	402					RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding	p.T405fs*5(2)		endometrium(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	17		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		TGGCTTCTTTAAAAAAAACAA	0.333													11	31	---	---	---	---					
FNIP2	57600	broad.mit.edu	37	4	159789994	159789994	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr4:159789994delA	ENST00000264433.6	+	13	2281	c.2206delA	c.(2206-2208)aaafs	p.K737fs	FNIP2_ENST00000379346.3_Frame_Shift_Del_p.K760fs	NM_020840.1	NP_065891.1	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	737	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		AAGCCGCATGAAAAAAATGGA	0.522													18	82	---	---	---	---					
DHX29	54505	broad.mit.edu	37	5	54593119	54593119	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:54593119delT	ENST00000251636.5	-	3	517	c.369delA	c.(367-369)aaafs	p.K123fs		NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	123							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				ATACCTGCAATTTTTTGGCAG	0.313													12	35	---	---	---	---					
SMIM15	643155	broad.mit.edu	37	5	60455819	60455819	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:60455819delT	ENST00000339020.3	-	3	605	c.180delA	c.(178-180)aaafs	p.K60fs	SMIM15_ENST00000507416.1_Frame_Shift_Del_p.K60fs	NM_001048249.3	NP_001041714.1			small integral membrane protein 15																		TTTCTTGGCGTTTTTGCTTCT	0.418													21	93	---	---	---	---					
IPO11	51194	broad.mit.edu	37	5	61770244	61770245	+	Splice_Site	INS	-	-	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:61770244_61770245insT	ENST00000325324.6	+	8	879_880	c.710_711insT	c.(709-714)ggtttt>ggTtttt	p.GF237fs	IPO11_ENST00000409296.3_Splice_Site_p.GF277fs|KIF2A_ENST00000509663.2_Intron	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	237				G -> V (in Ref. 2; BAG63985).		cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		CTTTTCTAGGGTTTTTTACATG	0.277													12	104	---	---	---	---					
GTF2H2B	653238	broad.mit.edu	37	5	69717512	69717512	+	RNA	DEL	G	G	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:69717512delG	ENST00000513202.1	+	0	275					NR_033417.1																						TTTTTTTTGTGGGGGGGGATA	0.303													10	41	---	---	---	---					
ARHGEF28	64283	broad.mit.edu	37	5	73181827	73181827	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:73181827delA	ENST00000545377.1	+	25	3384	c.3208delA	c.(3208-3210)aaafs	p.K1070fs	ARHGEF28_ENST00000512883.1_Frame_Shift_Del_p.K34fs|ARHGEF28_ENST00000513042.2_Frame_Shift_Del_p.K1070fs|ARHGEF28_ENST00000426542.2_Frame_Shift_Del_p.K1070fs|ARHGEF28_ENST00000296799.4_Frame_Shift_Del_p.K757fs|ARHGEF28_ENST00000296794.6_Frame_Shift_Del_p.K1070fs|ARHGEF28_ENST00000437974.1_Frame_Shift_Del_p.K1070fs|ARHGEF28_ENST00000287898.5_Frame_Shift_Del_p.K1070fs	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		CACGAAGCTCAAAAATGGACA	0.363													14	32	---	---	---	---					
CHD1	1105	broad.mit.edu	37	5	98206408	98206409	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:98206408_98206409insT	ENST00000284049.3	-	28	4109_4110	c.3960_3961insA	c.(3958-3963)aaagaafs	p.E1321fs	CHD1_ENST00000511067.1_5'UTR	NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1321					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding	p.E1321fs*22(1)		NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	GAAAGAGCTTCTTTTTTTGCAA	0.381													16	103	---	---	---	---					
PCDHB10	56126	broad.mit.edu	37	5	140574349	140574350	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:140574349_140574350insG	ENST00000239446.4	+	1	2408_2409	c.2224_2225insG	c.(2224-2226)aggfs	p.R742fs		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		742					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGACGTGAGGGGCGCTGAG	0.629													19	137	---	---	---	---					
LARS	51520	broad.mit.edu	37	5	145523014	145523014	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr5:145523014delC	ENST00000394434.2	-	19	2004	c.1838delG	c.(1837-1839)ggtfs	p.G613fs	LARS_ENST00000545646.1_Frame_Shift_Del_p.G567fs|LARS_ENST00000510191.1_Frame_Shift_Del_p.G559fs|LARS_ENST00000274562.9_Frame_Shift_Del_p.G586fs	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	613					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	ATGCAAGTTACCCCCCTGCAA	0.453													42	254	---	---	---	---					
NRM	11270	broad.mit.edu	37	6	30657966	30657967	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:30657966_30657967insG	ENST00000259953.4	-	3	538_539	c.187_188insC	c.(187-189)ctgfs	p.L63fs	NRM_ENST00000376421.5_Frame_Shift_Ins_p.L63fs|NRM_ENST00000376420.5_Frame_Shift_Ins_p.L63fs|NRM_ENST00000470733.1_5'UTR	NM_007243.2	NP_009174.1	Q8IXM6	NRM_HUMAN	nurim (nuclear envelope membrane protein)	63						integral to membrane|nuclear inner membrane				large_intestine(1)|lung(2)	3						ATCCCATGCCAGGGGGGCAAGG	0.569													7	40	---	---	---	---					
MDC1	9656	broad.mit.edu	37	6	30671965	30671965	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:30671965delG	ENST00000376406.3	-	10	5642	c.4995delC	c.(4993-4995)cccfs	p.P1665fs	MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Frame_Shift_Del_p.P1401fs	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1665					cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						ACTGGTCTGTGGGGGTAAAAG	0.537								Other conserved DNA damage response genes					24	104	---	---	---	---					
AARS2	57505	broad.mit.edu	37	6	44272425	44272425	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:44272425delC	ENST00000244571.4	-	12	1711	c.1709delG	c.(1708-1710)ggcfs	p.G570fs	TMEM151B_ENST00000438774.2_Intron|RP11-444E17.6_ENST00000505802.1_Intron	NM_020745.3	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	570					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	TGAAGCCTGGCCCCCCTGTTC	0.617											OREG0017473	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	33	---	---	---	---					
CDC5L	988	broad.mit.edu	37	6	44371655	44371656	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:44371655_44371656insA	ENST00000371477.3	+	6	948_949	c.649_650insA	c.(649-651)gaafs	p.E217fs		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	217					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AATCCCATTTGAAAAAAAGCCT	0.401													16	66	---	---	---	---					
RUNX2	860	broad.mit.edu	37	6	45390487	45390504	+	In_Frame_Del	DEL	GGCGGCGGCGGCGGCTGC	GGCGGCGGCGGCGGCTGC	-	rs11498192		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr6:45390487_45390504delGGCGGCGGCGGCGGCTGC	ENST00000371438.1	+	2	574_591	c.216_233delGGCGGCGGCGGCGGCTGC	c.(214-234)gaggcggcggcggcggctgcg>gag	p.AAAAAA79del	RUNX2_ENST00000359524.5_In_Frame_Del_p.AAAAAA65del|RUNX2_ENST00000465038.2_In_Frame_Del_p.AAAAAA79del|RUNX2_ENST00000371436.6_In_Frame_Del_p.AAAAAA79del|RUNX2_ENST00000352853.5_In_Frame_Del_p.AAAAAA147del|RUNX2_ENST00000576263.1_In_Frame_Del_p.AAAAAA79del|RUNX2_ENST00000371432.3_In_Frame_Del_p.AAAAAA65del|RUNX2_ENST00000541979.1_In_Frame_Del_p.AAAAAA147del	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	79	Poly-Ala.		Missing.		negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						agcagcaggaggcggcggcggcggctgcggcggcggcg	0.729													8	10	---	---	---	---					
LRGUK	136332	broad.mit.edu	37	7	133906656	133906656	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:133906656delA	ENST00000285928.2	+	16	2038	c.1969delA	c.(1969-1971)aaafs	p.K658fs		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	658							ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						ACTTTCAGCCAAAAAAACACC	0.388													10	46	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149504082	149504082	+	RNA	DEL	G	G	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr7:149504082delG	ENST00000378016.2	+	0	8903							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AACAACTGGTGGGTCACAGCG	0.662													2	4	---	---	---	---					
ATP6V1H	51606	broad.mit.edu	37	8	54708340	54708341	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:54708340_54708341insA	ENST00000355221.3	-	8	1241_1242	c.682_683insT	c.(682-684)tcafs	p.S228fs	ATP6V1H_ENST00000520188.1_Frame_Shift_Ins_p.S206fs|ATP6V1H_ENST00000396774.2_Frame_Shift_Ins_p.S246fs|ATP6V1H_ENST00000359530.2_Frame_Shift_Ins_p.S246fs	NM_213619.2	NP_998784.1	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H	246					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism			endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|urinary_tract(1)	18		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			GAGCCATATTGAAAAAATCATT	0.381													13	59	---	---	---	---					
EFR3A	23167	broad.mit.edu	37	8	132982802	132982802	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:132982802delG	ENST00000254624.5	+	10	1296	c.1071delG	c.(1069-1071)cagfs	p.Q357fs	EFR3A_ENST00000334503.4_Frame_Shift_Del_p.Q357fs|EFR3A_ENST00000519656.1_Frame_Shift_Del_p.Q321fs	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	357						plasma membrane	binding	p.S348fs*15(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			ATGATTTACAGGGGGGATCTG	0.403													18	73	---	---	---	---					
MIR30D	407033	broad.mit.edu	37	8	135817139	135817139	+	RNA	DEL	G	G	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr8:135817139delG	ENST00000362283.1	-	0	49					NR_029599.1																						ACATCTGACTGAAAGCTTAGC	0.428													9	212	---	---	---	---					
PLGRKT	55848	broad.mit.edu	37	9	5361173	5361173	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:5361173delT	ENST00000223864.2	-	5	448	c.227delA	c.(226-228)aagfs	p.K77fs		NM_018465.3	NP_060935.2	Q9HBL7	CI046_HUMAN	plasminogen receptor, C-terminal lysine transmembrane protein	77						integral to membrane											GGCTGGCTTCTTTTTTTTAAT	0.343													17	50	---	---	---	---					
PGM5P2	595135	broad.mit.edu	37	9	69082101	69082102	+	RNA	INS	-	-	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:69082101_69082102insT	ENST00000591037.1	-	0	1444					NR_002836.2																						TATCAATTTTATTTTTTAGGAA	0.302													4	9	---	---	---	---					
ACTL7B	10880	broad.mit.edu	37	9	111618046	111618047	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:111618046_111618047insT	ENST00000374667.3	-	1	1192_1193	c.164_165insA	c.(163-165)gacfs	p.D55fs		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	55						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						GGGAGCCCAGGTCGATGATGAC	0.663													17	105	---	---	---	---					
TOR1A	1861	broad.mit.edu	37	9	132584978	132584978	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:132584978delT	ENST00000351698.4	-	2	374	c.326delA	c.(325-327)aatfs	p.N109fs	TOR1A_ENST00000473084.1_5'UTR	NM_000113.2	NP_000104.1	O14656	TOR1A_HUMAN	torsin family 1, member A (torsin A)	109					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20		Ovarian(14;0.00556)				GCTGACGAAATTTTTGCCGGT	0.468													15	169	---	---	---	---					
USP20	10868	broad.mit.edu	37	9	132641854	132641854	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:132641854delC	ENST00000315480.4	+	24	2673	c.2515delC	c.(2515-2517)cccfs	p.P840fs	USP20_ENST00000358355.1_Frame_Shift_Del_p.P840fs|USP20_ENST00000372429.3_Frame_Shift_Del_p.P840fs|USP20_ENST00000472108.1_3'UTR			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	840	DUSP 2.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				TGTTGCAGAGCCCCCCGGGCC	0.667													11	101	---	---	---	---					
CEL	1056	broad.mit.edu	37	9	135946988	135946988	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr9:135946988delC	ENST00000372080.4	+	11	2124	c.2108delC	c.(2107-2109)gccfs	p.A703fs	CEL_ENST00000351304.7_Frame_Shift_Del_p.A634fs	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	700	17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GACTCCGGGGCCCCCCCCGTG	0.821													2	4	---	---	---	---					
RTKN2	219790	broad.mit.edu	37	10	63958149	63958149	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:63958149delT	ENST00000373789.3	-	12	1444	c.1348delA	c.(1348-1350)attfs	p.I450fs	RTKN2_ENST00000315289.2_Frame_Shift_Del_p.I252fs|RTKN2_ENST00000395265.1_Frame_Shift_Del_p.I471fs	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2	450					signal transduction	intracellular		p.I450fs*67(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					GTCTCTTCAATTTTTTTTTGT	0.333													9	63	---	---	---	---					
AGAP11	119385	broad.mit.edu	37	10	88754500	88754501	+	RNA	INS	-	-	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:88754500_88754501insA	ENST00000444431.1	+	0	255				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										TGGATGCAGTTAAAAAATGAAA	0.302													3	6	---	---	---	---					
BLNK	29760	broad.mit.edu	37	10	97960799	97960799	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:97960799delC	ENST00000224337.5	-	14	1091	c.950delG	c.(949-951)ggafs	p.G317fs	BLNK_ENST00000371176.2_Frame_Shift_Del_p.G294fs|BLNK_ENST00000413476.2_Frame_Shift_Del_p.G317fs|BLNK_ENST00000427367.2_Frame_Shift_Del_p.G317fs	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	317					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		AGTTGGGTTTCCCCCTTCTGT	0.403													9	87	---	---	---	---					
TAF5	6877	broad.mit.edu	37	10	105139367	105139368	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:105139367_105139368insT	ENST00000369839.3	+	4	1139_1140	c.1116_1117insT	c.(1117-1119)tttfs	p.F373fs	TAF5_ENST00000351396.4_Frame_Shift_Ins_p.F373fs	NM_006951.3	NP_008882.2	Q15542	TAF5_HUMAN	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	373					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding	p.F374fs*4(1)		breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)	15		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		ACTTGTAGGTATTTTTTGGTTT	0.287													8	26	---	---	---	---					
MKI67	4288	broad.mit.edu	37	10	129904535	129904535	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr10:129904535delT	ENST00000368654.3	-	13	5944	c.5569delA	c.(5569-5571)atafs	p.I1857fs	MKI67_ENST00000368653.3_Frame_Shift_Del_p.I1497fs	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1857	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTGCAGAGTATTTTTTTGGTA	0.483													9	240	---	---	---	---					
PATL1	219988	broad.mit.edu	37	11	59425145	59425146	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:59425145_59425146insG	ENST00000300146.9	-	5	562_563	c.478_479insC	c.(478-480)cagfs	p.Q160fs		NM_152716.2	NP_689929.2	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog 1 (yeast)	160	Pro-rich.|Region N; interaction with decapping machinery.			Q -> H (in Ref. 2; BAG54601).	cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			central_nervous_system(1)|endometrium(2)|lung(5)|ovary(1)|prostate(2)	11						TTCTGGACCCTGGGGGGGCCTC	0.455													12	30	---	---	---	---					
C11orf57	55216	broad.mit.edu	37	11	111953289	111953289	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:111953289delA	ENST00000532163.1	+	6	1154	c.388delA	c.(388-390)aaafs	p.K132fs	C11orf57_ENST00000280352.9_Frame_Shift_Del_p.K160fs|C11orf57_ENST00000420986.2_Frame_Shift_Del_p.K160fs|C11orf57_ENST00000393047.3_Frame_Shift_Del_p.K161fs			Q6ZUT1	CK057_HUMAN	chromosome 11 open reading frame 57	160										autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	12		all_cancers(61;9.8e-15)|all_epithelial(67;6.57e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.6e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;7.01e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0521)		GAAATCCCACAAAAAAAAGCA	0.393													12	51	---	---	---	---					
SORL1	6653	broad.mit.edu	37	11	121483537	121483538	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr11:121483537_121483538insA	ENST00000260197.7	+	40	5544_5545	c.5415_5416insA	c.(5416-5418)aaafs	p.K1806fs	SORL1_ENST00000532694.1_Frame_Shift_Ins_p.K652fs|SORL1_ENST00000527934.1_Frame_Shift_Ins_p.K421fs|SORL1_ENST00000525532.1_Frame_Shift_Ins_p.K750fs|SORL1_ENST00000534286.1_Frame_Shift_Ins_p.K716fs	NM_003105.5	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1806	Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TATTGTCACACAAAGGTAACAC	0.525													7	16	---	---	---	---					
C1S	716	broad.mit.edu	37	12	7171653	7171653	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:7171653delC	ENST00000406697.1	+	8	1102	c.474delC	c.(472-474)tgcfs	p.C158fs	C1S_ENST00000328916.3_Frame_Shift_Del_p.C158fs|C1S_ENST00000402681.3_5'UTR|C1S_ENST00000360817.5_Frame_Shift_Del_p.C158fs			P09871	C1S_HUMAN	complement component 1, s subcomponent	158	EGF-like; calcium-binding.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TCTGCTCCTGCCCCCCGGAAT	0.453													19	104	---	---	---	---					
ASUN	55726	broad.mit.edu	37	12	27066991	27066992	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:27066991_27066992insT	ENST00000261191.7	-	13	2025_2026	c.1489_1490insA	c.(1489-1491)acafs	p.T497fs	ASUN_ENST00000539625.1_Frame_Shift_Ins_p.T396fs	NM_018164.2	NP_060634.2	Q9NVM9	M89BB_HUMAN	asunder spermatogenesis regulator	497					cell division|mitosis|regulation of mitotic cell cycle		protein binding										GTTGTATATTGTTTTTTGACAG	0.312													13	76	---	---	---	---					
ALG10B	144245	broad.mit.edu	37	12	38714286	38714286	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:38714286delA	ENST00000308742.4	+	3	1009	c.693delA	c.(691-693)agafs	p.R231fs	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	231					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				CAGAATTCAGAAAAATTCTTC	0.373													11	122	---	---	---	---					
CDK4	1019	broad.mit.edu	37	12	58145367	58145369	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:58145367_58145369delCCT	ENST00000257904.6	-	2	497_499	c.132_134delAGG	c.(130-135)ggaggt>ggt	p.44_45GG>G	CDK4_ENST00000540325.1_5'UTR|CDK4_ENST00000312990.6_In_Frame_Del_p.44_45GG>G|CDK4_ENST00000549606.1_Intron|CDK4_ENST00000551888.1_5'UTR	NM_000075.3	NP_000066.1	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	44	Poly-Gly.|Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	21	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			GCCTCCTCCACCTCCTCCTCCAT	0.567			Mis			melanoma			Hereditary Melanoma				10	73	---	---	---	---					
SPIC	121599	broad.mit.edu	37	12	101880233	101880234	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:101880233_101880234insA	ENST00000551346.1	+	6	590_591	c.431_432insA	c.(430-435)tcaaaafs	p.SK144fs	SPIC_ENST00000299272.5_Frame_Shift_Ins_p.SK144fs			Q8N5J4	SPIC_HUMAN	Spi-C transcription factor (Spi-1/PU.1 related)	144						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	22						CAGTTTGTATCAAAAAACAAAG	0.421													8	65	---	---	---	---					
ANKRD13A	88455	broad.mit.edu	37	12	110451041	110451041	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr12:110451041delA	ENST00000261739.4	+	3	507	c.341delA	c.(340-342)caafs	p.Q114fs	ANKRD13A_ENST00000550404.1_3'UTR	NM_033121.1	NP_149112.1	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13A	114										endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(8)|lung(3)|urinary_tract(1)	16						GAGCTGCTCCAAAAAATTCTC	0.478													9	58	---	---	---	---					
RP11-643G16.4	0	broad.mit.edu	37	14	68082888	68082888	+	RNA	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:68082888delA	ENST00000559968.1	+	0	1243																											TTTTAAAGACAAAAAAAATTT	0.328													12	82	---	---	---	---					
ATG2B	55102	broad.mit.edu	37	14	96783572	96783572	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr14:96783572delT	ENST00000359933.4	-	20	4013	c.3120delA	c.(3118-3120)aaafs	p.K1040fs		NM_018036.5	NP_060506	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1040										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GAGAGTCTAATTTTTTTTTCC	0.368													8	51	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25304706	25304706	+	RNA	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:25304706delA	ENST00000549804.2	+	0	99				SNHG14_ENST00000384733.1_RNA																							GAGTCCCCCCAAAAAAACATT	0.502													8	256	---	---	---	---					
MAP1A	4130	broad.mit.edu	37	15	43821166	43821166	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:43821166delC	ENST00000382031.1	+	5	8240	c.8209delC	c.(8209-8211)cccfs	p.P2738fs	MAP1A_ENST00000300231.5_Frame_Shift_Del_p.P2500fs|MAP1A_ENST00000399453.1_Frame_Shift_Del_p.P2500fs			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2500						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TGATGAGACACCCCCTACATC	0.622													10	70	---	---	---	---					
VPS13C	54832	broad.mit.edu	37	15	62283898	62283898	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:62283898delT	ENST00000261517.5	-	17	1530	c.1457delA	c.(1456-1458)aagfs	p.K486fs	VPS13C_ENST00000395898.3_Frame_Shift_Del_p.K443fs|VPS13C_ENST00000249837.3_Frame_Shift_Del_p.K443fs|VPS13C_ENST00000395896.4_Frame_Shift_Del_p.K486fs	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	486					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						TTCTTCGTCCTTTTTCTTAGA	0.373													33	165	---	---	---	---					
IQCH	64799	broad.mit.edu	37	15	67681233	67681234	+	Frame_Shift_Ins	INS	-	-	A	rs138548169	byFrequency	TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:67681233_67681234insA	ENST00000335894.4	+	12	1587_1588	c.1521_1522insA	c.(1522-1524)aaafs	p.K508fs	IQCH_ENST00000546225.1_Frame_Shift_Ins_p.K256fs|IQCH_ENST00000358767.3_Frame_Shift_Ins_p.K335fs|IQCH_ENST00000360277.4_Frame_Shift_Ins_p.K260fs	NM_001031715.2	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H	508										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		TGCTGTATTACAAAAAAATCCT	0.406													17	55	---	---	---	---					
FANCI	55215	broad.mit.edu	37	15	89850742	89850742	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:89850742delA	ENST00000310775.7	+	33	3659	c.3573delA	c.(3571-3573)ccafs	p.P1191fs	FANCI_ENST00000300027.8_Frame_Shift_Del_p.P1131fs	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	1191					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					GAGGAATTCCAAAAAATATGG	0.423								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				11	51	---	---	---	---					
LOC440311	440311	broad.mit.edu	37	15	95399991	95399991	+	RNA	DEL	C	C	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr15:95399991delC	ENST00000602330.1	-	0	249																											CAGACTCGCTCAGGACCCTGA	0.622													2	4	---	---	---	---					
RP11-652G5.1	0	broad.mit.edu	37	16	32616500	32616500	+	RNA	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:32616500delT	ENST00000562976.1	+	0	304																											GCAGAAAGAATTTTTTTAGGG	0.363													2	4	---	---	---	---					
snoU13	0	broad.mit.edu	37	16	53368511	53368512	+	RNA	DEL	CA	CA	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr16:53368511_53368512delCA	ENST00000459097.1	+	0	38_39																											attgggtgttcacacacatatg	0.351													10	48	---	---	---	---					
SLC16A11	162515	broad.mit.edu	37	17	6945674	6945674	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:6945674delC	ENST00000308009.1	-	3	1164	c.827delG	c.(826-828)ggafs	p.G276fs	SLC16A11_ENST00000447225.1_Frame_Shift_Del_p.G252fs	NM_153357.1	NP_699188.1	Q8NCK7	MOT11_HUMAN	solute carrier family 16, member 11	276						integral to membrane|plasma membrane	symporter activity			endometrium(2)|kidney(2)|lung(2)|ovary(1)|skin(2)	9						TGCTCCGTATCCCCCCAGGCC	0.682													2	4	---	---	---	---					
LOC101927060	101927060	broad.mit.edu	37	17	45128651	45128652	+	RNA	INS	-	-	T			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:45128651_45128652insT	ENST00000575173.1	-	0	418																											ttgtttttttgttttttttAGC	0.297													12	108	---	---	---	---					
LOC101927755	101927755	broad.mit.edu	37	17	58066608	58066608	+	RNA	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:58066608delT	ENST00000586209.1	+	0	158																											TTGATTGTGATTTTTTTTTTT	0.313													4	8	---	---	---	---					
GPRC5C	55890	broad.mit.edu	37	17	72436470	72436470	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:72436470delG	ENST00000392627.1	+	2	1816	c.690delG	c.(688-690)gagfs	p.E230fs	GPRC5C_ENST00000342648.5_Intron|GPRC5C_ENST00000481232.1_Intron|GPRC5C_ENST00000392629.2_Frame_Shift_Del_p.E197fs	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	185						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						GCAGTGGCGAGGGCGGCCCTC	0.617													14	42	---	---	---	---					
CCDC137	339230	broad.mit.edu	37	17	79634764	79634766	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr17:79634764_79634766delAGA	ENST00000329214.8	+	2	543_545	c.140_142delAGA	c.(139-144)gagaag>gag	p.K50del		NM_199287.2	NP_954981.1	Q6PK04	CC137_HUMAN	coiled-coil domain containing 137	50										NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(2)	12	all_neural(118;0.0878)|all_lung(278;0.23)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			CCCAGCAAAGAGAAGAAGAAAGT	0.488													20	40	---	---	---	---					
SOGA2	23255	broad.mit.edu	37	18	8793003	8793004	+	Frame_Shift_Ins	INS	-	-	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr18:8793003_8793004insC	ENST00000359865.3	+	8	2037_2038	c.1895_1896insC	c.(1894-1899)ggccccfs	p.GP632fs	SOGA2_ENST00000518815.1_Intron|SOGA2_ENST00000306329.11_Intron|SOGA2_ENST00000306285.7_5'UTR|SOGA2_ENST00000400050.3_Intron|SOGA2_ENST00000517570.1_Intron	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	980								p.G632A(1)									CAGCTCAGGGGCCCCCCCGTTT	0.554													19	131	---	---	---	---					
SLC25A41	284427	broad.mit.edu	37	19	6433605	6433605	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:6433605delG	ENST00000321510.6	-	1	168	c.100delC	c.(100-102)caafs	p.Q34fs		NM_173637.3	NP_775908.2	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	34	Pro-rich.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			large_intestine(1)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	6						ggcggaggttgggggggaggc	0.577													12	41	---	---	---	---					
ZSWIM4	65249	broad.mit.edu	37	19	13941839	13941839	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:13941839delT	ENST00000254323.2	+	13	3134	c.2945delT	c.(2944-2946)cttfs	p.L983fs	ZSWIM4_ENST00000440752.2_Frame_Shift_Del_p.L817fs	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	983							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			AAACTCATGCTTTTGGTGCGG	0.612													11	50	---	---	---	---					
DCAF15	90379	broad.mit.edu	37	19	14069917	14069918	+	Frame_Shift_Ins	INS	-	-	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:14069917_14069918insC	ENST00000254337.6	+	7	866_867	c.845_846insC	c.(844-849)agccccfs	p.SP282fs		NM_138353.2	NP_612362.2	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	282								p.E285fs*1(1)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)	11						GCGCCTGCCAGCCCCCCTGAGC	0.663													10	46	---	---	---	---					
ZNF616	90317	broad.mit.edu	37	19	52618226	52618226	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr19:52618226delA	ENST00000600228.1	-	4	2452	c.2191delT	c.(2191-2193)tccfs	p.S731fs	ZNF616_ENST00000330123.5_3'UTR	NM_178523.3	NP_848618.2	Q08AN1	ZN616_HUMAN	zinc finger protein 616	731					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		TTGCTGAGGGAAAACAACCGC	0.398													23	120	---	---	---	---					
JAG1	182	broad.mit.edu	37	20	10639116	10639117	+	Splice_Site	DEL	CT	CT	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:10639116_10639117delCT	ENST00000254958.5	-	4	1208_1209	c.693_694delAG	c.(691-696)agagct>agct	p.RA231fs	JAG1_ENST00000423891.2_Splice_Site_p.RA72fs	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	231	EGF-like 1.				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						ACACACATACCTCTGTTACATT	0.535									Alagille Syndrome				14	90	---	---	---	---					
MACROD2	140733	broad.mit.edu	37	20	16030476	16030477	+	Splice_Site	INS	-	-	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr20:16030476_16030477insG	ENST00000217246.4	+	17	1628_1629	c.1233_1234insG	c.(1234-1236)ggg>Gggg	p.G412fs	MACROD2_ENST00000407045.3_Splice_Site|MACROD2_ENST00000378058.3_Splice_Site_p.G200fs|MACROD2_ENST00000310348.4_Splice_Site_p.G435fs|MACROD2_ENST00000402914.1_Splice_Site_p.G200fs	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	435										breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				TGTCTTCAGCAGGGGCACAAGA	0.431													10	39	---	---	---	---					
DSCAM	1826	broad.mit.edu	37	21	41514614	41514615	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr21:41514614_41514615insG	ENST00000400454.1	-	18	3753_3754	c.3276_3277insC	c.(3274-3279)cccgaafs	p.E1093fs		NM_001271534.1|NM_001389.3	NP_001258463.1|NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1093	Fibronectin type-III 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding	p.E1093K(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGACATTTTCGGGGGGGTAAC	0.406													27	114	---	---	---	---					
CCDC116	164592	broad.mit.edu	37	22	21989445	21989446	+	Frame_Shift_Ins	INS	-	-	C			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:21989445_21989446insC	ENST00000292779.3	+	4	1254_1255	c.1093_1094insC	c.(1093-1095)tccfs	p.S365fs	CCDC116_ENST00000607942.1_Frame_Shift_Ins_p.S365fs	NM_152612.2	NP_689825.2	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	365										endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(5)	22	Colorectal(54;0.105)					GCCCTATGCTTCCCCCCGCCCC	0.634													7	27	---	---	---	---					
ADRBK2	157	broad.mit.edu	37	22	26117308	26117308	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chr22:26117308delA	ENST00000324198.6	+	20	2041	c.1849delA	c.(1849-1851)aaafs	p.K618fs		NM_005160.3	NP_005151.2	P35626	ARBK2_HUMAN	adrenergic, beta, receptor kinase 2		PH.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|skin(3)|stomach(2)	32					Adenosine triphosphate(DB00171)	AATTAAAGACAAAAAATGCAT	0.269													15	70	---	---	---	---					
MID1	4281	broad.mit.edu	37	X	10417614	10417614	+	Frame_Shift_Del	DEL	G	G	-	rs1802191		TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:10417614delG	ENST00000317552.4	-	10	2198	c.1798delC	c.(1798-1800)cacfs	p.H600fs	MID1_ENST00000479925.1_5'UTR|MID1_ENST00000453318.2_Frame_Shift_Del_p.H600fs|MID1_ENST00000380787.1_Frame_Shift_Del_p.H600fs|MID1_ENST00000380782.2_3'UTR|MID1_ENST00000380779.1_Frame_Shift_Del_p.H600fs|MID1_ENST00000380780.1_Frame_Shift_Del_p.H600fs|MID1_ENST00000380785.1_Frame_Shift_Del_p.H600fs	NM_000381.3|NM_033289.1	NP_000372.1|NP_150631.1	O15344	TRI18_HUMAN	midline 1 (Opitz/BBB syndrome)	600	B30.2/SPRY.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	26						CGCCGGAGGTGGGGGGCAGGC	0.542													14	31	---	---	---	---					
CUL4B	8450	broad.mit.edu	37	X	119669705	119669706	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-ZF-AA4W-01A-12D-A38G-08	TCGA-ZF-AA4W-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28d8a3b3-5241-4596-9711-7327780245a8	7bf15a68-13ce-4b7e-9d6e-d0d8bc8eed4f	g.chrX:119669705_119669706delAC	ENST00000371322.5	-	16	2200_2201	c.2139_2140delGT	c.(2137-2142)gtgttafs	p.L714fs	CUL4B_ENST00000404115.3_Frame_Shift_Del_p.L732fs|CUL4B_ENST00000336592.6_Frame_Shift_Del_p.L719fs	NM_001079872.1	NP_001073341.1	Q13620	CUL4B_HUMAN	cullin 4B	732					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TCTGCTTTTAACACACAGTGTC	0.356													22	64	---	---	---	---					
