Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MREG	55686	broad.mit.edu	37	2	216809708	216809708	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:216809708C>T	ENST00000263268.6	-	5	818	c.523G>A	c.(523-525)Gca>Aca	p.A175T		NM_018000.2	NP_060470.2	Q8N565	MREG_HUMAN	melanoregulin	175						apical plasma membrane				large_intestine(1)|lung(2)	3		Renal(323;0.0328)		Epithelial(149;4.64e-07)|all cancers(144;5.56e-05)|LUSC - Lung squamous cell carcinoma(224;0.00832)|Lung(261;0.0111)		GCATCAAGTGCAATGAGACGG	0.453000													6	16					0	0	1	0	0
ZNF165	7718	broad.mit.edu	37	6	28056923	28056923	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:28056923G>A	ENST00000377325.1	+	4	1689	c.1133G>A	c.(1132-1134)gGg>gAg	p.G378E		NM_003447.3	NP_003438.1	P49910	ZN165_HUMAN	zinc finger protein 165	378					viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AATGAATGTGGGAAAAGCTTT	0.453000													29	37					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108117775	108117775	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:108117775G>C	ENST00000278616.4	+	8	1371	c.986G>C	c.(985-987)aGa>aCa	p.R329T	ATM_ENST00000452508.2_Missense_Mutation_p.R329T	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	329					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATAGGAAGTAGAGGAAAGTAT	0.333000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			18	24					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157525118	157525118	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:157525118C>G	ENST00000346085.5	+	19	5014	c.5013C>G	c.(5011-5013)ttC>ttG	p.F1671L	ARID1B_ENST00000350026.5_Missense_Mutation_p.F1658L|ARID1B_ENST00000275248.4_Missense_Mutation_p.F1653L|ARID1B_ENST00000367148.1_Missense_Mutation_p.F1711L	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1658					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TTGCTACTTTCAATCTCTCCC	0.433000													41	181					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68747779	68747779	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:68747779G>A	ENST00000309106.3	-	1	676	c.677C>T	c.(676-678)tCt>tTt	p.S226F		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	226						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CACCAGGACAGAGGCCAGGAC	0.617000													5	33					0	0	1	0	0
LRRC14	9684	broad.mit.edu	37	8	145745189	145745189	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:145745189C>T	ENST00000292524.1	+	2	226	c.80C>T	c.(79-81)cCa>cTa	p.P27L	LRRC14_ENST00000529022.1_Missense_Mutation_p.P27L	NM_001272036.1|NM_014665.2	NP_001258965.1|NP_055480.1	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	27										endometrium(1)|lung(3)|prostate(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CCCTTGCTGCCACGCGAACTC	0.632000													6	45					0	0	1	0	0
PRR7	80758	broad.mit.edu	37	5	176882984	176882984	+	Silent	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:176882984C>G	ENST00000323249.3	+	4	1177	c.687C>G	c.(685-687)ctC>ctG	p.L229L	PRR7_ENST00000510492.1_Silent_p.L229L|PRR7_ENST00000502922.1_Silent_p.L229L	NM_030567.4	NP_085044.2	Q8TB68	PRR7_HUMAN	proline rich 7 (synaptic)	229						cell junction|integral to membrane|postsynaptic membrane						all_cancers(89;1.51e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCCAGCCCTCTGCCTGCAGG	0.746000													3	5					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62289477	62289477	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:62289477G>A	ENST00000378024.4	-	5	12686	c.12412C>T	c.(12412-12414)Ctg>Ttg	p.L4138L	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4138					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GGACCTTTCAGATTCAGGTCA	0.512000													80	162					0	0	1	0	0
SLC25A13	10165	broad.mit.edu	37	7	95820470	95820470	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:95820470C>G	ENST00000416240.2	-	7	895	c.705G>C	c.(703-705)aaG>aaC	p.K235N	SLC25A13_ENST00000265631.5_Missense_Mutation_p.K235N|SLC25A13_ENST00000542654.1_Missense_Mutation_p.K127N	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	235					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	TGCTATAGATCTTTCTAATGA	0.388000													9	133					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198718610	198718610	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:198718610G>C	ENST00000367376.2	+	28	3169	c.2998G>C	c.(2998-3000)Gat>Cat	p.D1000H	PTPRC_ENST00000594404.1_Missense_Mutation_p.D839H|PTPRC_ENST00000442510.2_Missense_Mutation_p.D1002H|PTPRC_ENST00000348564.6_Missense_Mutation_p.D841H|PTPRC_ENST00000352140.3_Missense_Mutation_p.D952H	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1000	Tyrosine-protein phosphatase 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						GCATGATTCAGATGAATCCTC	0.368000													13	41					0	0	1	0	0
ING2	3622	broad.mit.edu	37	4	184431737	184431737	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:184431737G>A	ENST00000302327.3	+	2	677	c.475G>A	c.(475-477)Gaa>Aaa	p.E159K	ING2_ENST00000434682.2_Missense_Mutation_p.E119K	NM_001564.2	NP_001555.1	Q9H160	ING2_HUMAN	inhibitor of growth family, member 2	159					chromatin modification|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of growth|signal transduction|transcription, DNA-dependent	CCAAT-binding factor complex|Sin3 complex	chromatin binding|DNA binding|protein complex binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)	7		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|all_hematologic(60;0.0207)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GCGGACCAGTGAAAGCCGTGA	0.458000													18	32					0	0	1	0	0
COPS2	9318	broad.mit.edu	37	15	49420945	49420945	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:49420945C>G	ENST00000388901.5	-	12	1214	c.1141G>C	c.(1141-1143)Gat>Cat	p.D381H	COPS2_ENST00000542928.1_Missense_Mutation_p.D317H|COPS2_ENST00000299259.6_Missense_Mutation_p.D388H	NM_001143887.1|NM_004236.3	NP_001137359.1|NP_004227.1	P61201	CSN2_HUMAN	COP9 signalosome subunit 2	381	PCI.				cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(2)	18		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		TCAGCTACATCTATGTTTAAC	0.284000													54	140					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102611287	102611287	+	Missense_Mutation	SNP	G	G	C	rs145433541		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:102611287G>C	ENST00000251808.3	+	8	1344	c.1006G>C	c.(1006-1008)Gat>Cat	p.D336H	GRHL2_ENST00000395927.1_Missense_Mutation_p.D320H	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	336						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			TGTTACAGCCGATTACAAGGA	0.373000													4	40					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201462144	201462144	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:201462144G>A	ENST00000374700.2	+	4	466	c.225G>A	c.(223-225)ctG>ctA	p.L75L		NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	75	2Fe-2S ferredoxin-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	ATGCCTGTCTGATTCCCATCT	0.488000													10	36					0	0	1	0	0
CACNB4	785	broad.mit.edu	37	2	152711869	152711869	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:152711869C>G	ENST00000360283.6	-	10	1047	c.790G>C	c.(790-792)Gaa>Caa	p.E264Q	CACNB4_ENST00000534999.1_Missense_Mutation_p.E263Q|CACNB4_ENST00000397327.2_Missense_Mutation_p.E250Q|CACNB4_ENST00000539935.1_Missense_Mutation_p.E297Q|CACNB4_ENST00000427385.1_Missense_Mutation_p.E279Q|CACNB4_ENST00000201943.5_Missense_Mutation_p.E297Q			O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	297					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	AAGATTCTTTCAATTTCACTT	0.333000													4	30					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34072437	34072437	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:34072437C>G	ENST00000389232.4	+	65	9233	c.9163C>G	c.(9163-9165)Ctg>Gtg	p.L3055V	RYR3_ENST00000415757.3_Missense_Mutation_p.L3055V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3055					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGAGAATGTCTGGCCTCGCT	0.577000													3	35					0	0	1	0	0
SENP5	205564	broad.mit.edu	37	3	196612556	196612556	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:196612556G>A	ENST00000323460.5	+	2	753	c.504G>A	c.(502-504)atG>atA	p.M168I	SENP5_ENST00000419026.1_Intron|SENP5_ENST00000445299.2_Missense_Mutation_p.M168I	NM_152699.4	NP_689912.2	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	168					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(14)|skin(1)	32	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		ACTTTCCCATGAAGTTCAATG	0.483000													13	43					0	0	1	0	0
GID8	54994	broad.mit.edu	37	20	61572936	61572936	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:61572936G>C	ENST00000266069.3	+	2	229	c.82G>C	c.(82-84)Gac>Cac	p.D28H		NM_017896.2	NP_060366.1			GID complex subunit 8																		CCAGAGAGCAGACATGAACCG	0.418000													10	109					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87362199	87362199	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:87362199G>C	ENST00000327946.7	-	16	2946	c.2861C>G	c.(2860-2862)cCg>cGg	p.P954R	GRID1_ENST00000536331.1_Missense_Mutation_p.P525R|GRID1_ENST00000552278.2_5'UTR	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	954						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	GCTGCTCAGCGGCAGCGGCAG	0.652000										Multiple Myeloma(13;0.14)			9	49					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	283836	283836	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:283836G>A	ENST00000538872.1	+	14	3304	c.3186G>A	c.(3184-3186)gtG>gtA	p.V1062V	IQSEC3_ENST00000537151.1_3'UTR|RP11-598F7.6_ENST00000537295.1_lincRNA|IQSEC3_ENST00000326261.4_Silent_p.V1062V			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	1062	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GAGCGCCGGTGCCGCCGCCAG	0.662000													5	24					0	0	1	0	0
FOXK2	3607	broad.mit.edu	37	17	80545005	80545005	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:80545005C>T	ENST00000335255.5	+	8	1817	c.1643C>T	c.(1642-1644)aCg>aTg	p.T548M		NM_004514.3	NP_004505.2	Q01167	FOXK2_HUMAN	forkhead box K2	548					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	17	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			ATCATTCAGACGGCACAGACC	0.498000													16	89					0	0	1	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54640440	54640440	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:54640440G>C	ENST00000230640.5	+	9	1251	c.997G>C	c.(997-999)Gat>Cat	p.D333H	SKIV2L2_ENST00000545714.1_Missense_Mutation_p.D232H	NM_015360.4	NP_056175.3	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	333					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TCTTGTGGTTGATGAAAATGT	0.333000													7	29					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21445158	21445158	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:21445158G>A	ENST00000307378.6	-	13	2270	c.1550C>T	c.(1549-1551)tCa>tTa	p.S517L	SLCO1A2_ENST00000390670.3_Missense_Mutation_p.S515L|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.S517L|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.S385L|SLCO1A2_ENST00000458504.1_Missense_Mutation_p.S385L	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	517					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						GCTCATCGCTGACAAGATTAG	0.393000													10	37					0	0	1	0	0
SLC27A1	376497	broad.mit.edu	37	19	17598103	17598103	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:17598103C>T	ENST00000252595.7	+	3	780	c.683C>T	c.(682-684)tCt>tTt	p.S228F	SLC27A1_ENST00000442725.1_Missense_Mutation_p.S228F|SLC27A1_ENST00000598424.1_Missense_Mutation_p.S49F	NM_198580.1	NP_940982.1	Q6PCB7	S27A1_HUMAN	solute carrier family 27 (fatty acid transporter), member 1	228	Sufficient for oligomerization (By similarity).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						AAGGAGGCCTCTACTGCCCCC	0.622000													3	13					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	30723146	30723146	+	Silent	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:30723146C>A	ENST00000361762.2	+	1	1110	c.102C>A	c.(100-102)ctC>ctA	p.L34L	PCDH7_ENST00000543491.1_Silent_p.L34L	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	34	Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						AGCAGCTCCTCCGGTACCGGC	0.711000													3	18					1.23904e-05	1.32142e-05	1	1	0
PRRT3	285368	broad.mit.edu	37	3	9989099	9989099	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:9989099G>A	ENST00000412055.1	-	4	1887	c.1758C>T	c.(1756-1758)ctC>ctT	p.L586L	PRRT3-AS1_ENST00000431558.1_RNA	NM_207351.3	NP_997234.3	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3	586						integral to membrane				NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)|stomach(2)	13						GGTCTGTCGCGAGCAACCCTA	0.687000													11	30					0	0	1	0	0
MLH1	4292	broad.mit.edu	37	3	37058996	37058996	+	Splice_Site	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:37058996G>C	ENST00000231790.2	+	10	1006		c.e10-1		MLH1_ENST00000539477.1_Splice_Site|MLH1_ENST00000458205.2_Splice_Site|MLH1_ENST00000455445.2_Splice_Site|MLH1_ENST00000435176.1_Splice_Site|MLH1_ENST00000536378.1_Splice_Site	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1						mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						TTATTGTTTAGATCGTCTGGT	0.418000		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				10	57					0	0	1	0	0
HLA-F	3134	broad.mit.edu	37	6	29693324	29693324	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:29693324G>C	ENST00000440587.2	+	5	992	c.633G>C	c.(631-633)tgG>tgC	p.W211C	HLA-F_ENST00000259951.7_Missense_Mutation_p.W329C|HLA-F_ENST00000376861.1_Missense_Mutation_p.W329C|HLA-F_ENST00000334668.4_Missense_Mutation_p.W329C|HLA-F_ENST00000475996.1_3'UTR|HLA-F_ENST00000434407.2_Missense_Mutation_p.W237C			P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	329	Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8						CTGTGATGTGGAGGAAGAAGA	0.582000													62	54					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907795	77907795	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:77907795C>T	ENST00000355300.6	-	2	628	c.454G>A	c.(454-456)Gag>Aag	p.E152K	LINGO1_ENST00000561030.1_Missense_Mutation_p.E146K	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	152					negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						ATCTTGTTCTCGCTGATGTCC	0.552000													25	74					0	0	1	0	0
HCK	3055	broad.mit.edu	37	20	30681784	30681784	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:30681784G>A	ENST00000534862.1	+	12	1514	c.1151G>A	c.(1150-1152)cGg>cAg	p.R384Q	HCK_ENST00000538448.1_Missense_Mutation_p.R383Q|HCK_ENST00000520553.1_Missense_Mutation_p.R383Q|HCK_ENST00000518730.1_Missense_Mutation_p.R382Q|HCK_ENST00000375862.2_Missense_Mutation_p.R403Q|HCK_ENST00000375852.2_Missense_Mutation_p.R404Q	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	404	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGCCTGGCCCGGGTCATTGAG	0.552000													37	67					0	0	1	0	0
NXF5	55998	broad.mit.edu	37	X	101096056	101096056	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:101096056C>A	ENST00000537026.1	-	8	771	c.412G>T	c.(412-414)Gat>Tat	p.D138Y	NXF5_ENST00000473265.2_Missense_Mutation_p.D138Y|NXF5_ENST00000361708.2_Missense_Mutation_p.D138Y	NM_032946.2	NP_116564.2	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	138					mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|skin(1)	30						AGGATTATATCAATGTCACGG	0.512000													21	112					3.28513e-13	3.70461e-13	1	1	0
PADI6	353238	broad.mit.edu	37	1	17698755	17698755	+	RNA	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:17698755G>C	ENST00000434762.2	+	0	65							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TCAGCGTGGAGGGCCGAGCCA	0.607000													13	86					0	0	1	0	0
KCNH3	23416	broad.mit.edu	37	12	49943411	49943411	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:49943411C>G	ENST00000257981.6	+	9	1916	c.1656C>G	c.(1654-1656)atC>atG	p.I552M		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	552					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						ACAATGGCATCGACACCACCG	0.617000													5	21					0	0	1	0	0
GATC	283459	broad.mit.edu	37	12	120894928	120894928	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:120894928G>A	ENST00000551765.1	+	3	347	c.304G>A	c.(304-306)Gaa>Aaa	p.E102K	AL021546.6_ENST00000551806.1_Silent_p.*133*	NM_176818.2	NP_789788.1	O43716	GATCL_HUMAN	glutamyl-tRNA(Gln) amidotransferase, subunit C	102					regulation of translational fidelity					breast(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTGTGCTGATGAATTACTACA	0.488000											OREG0022192	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	49					0	0	1	0	0
PEX6	5190	broad.mit.edu	37	6	42933441	42933441	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:42933441C>G	ENST00000304611.8	-	13	2518	c.2449G>C	c.(2449-2451)Gat>Cat	p.D817H	PEX6_ENST00000244546.4_Missense_Mutation_p.E734D	NM_000287.3	NP_000278.3	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	817					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(3)	15			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			CCTCCAGAATCTCCACTTCGC	0.547000													45	255					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127622437	127622437	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:127622437G>A	ENST00000508053.1	-	61	7959	c.6985C>T	c.(6985-6987)Cga>Tga	p.R2329*	FBN2_ENST00000262464.4_Nonsense_Mutation_p.R2329*			P35556	FBN2_HUMAN	fibrillin 2	2329	EGF-like 39; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCGGGCCTTCGGGCCATTCCA	0.517000													4	38					0	0	1	0	0
TBCE	6905	broad.mit.edu	37	1	235599912	235599912	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:235599912C>G	ENST00000543662.1	+	12	1211	c.1105C>G	c.(1105-1107)Cag>Gag	p.Q369E	TBCE_ENST00000366601.3_Missense_Mutation_p.Q318E|TBCE_ENST00000406207.1_Missense_Mutation_p.Q318E|TBCE_ENST00000472011.1_3'UTR			Q15813	TBCE_HUMAN	tubulin folding cofactor E	318	LRRCT.				'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding			NS(1)|endometrium(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	14	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			AAACGACAATCAGATATCACA	0.433000													16	30					0	0	1	0	0
TTC17	55761	broad.mit.edu	37	11	43380573	43380573	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:43380573C>T	ENST00000039989.4	+	1	83	c.69C>T	c.(67-69)ctC>ctT	p.L23L	TTC17_ENST00000299240.6_Silent_p.L23L|RP11-484D2.2_ENST00000526220.1_RNA	NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	23							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						GCTGGCTCCTCAGCCTTTCCG	0.711000													6	4					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81719608	81719608	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:81719608C>T	ENST00000550584.2	-	21	2885	c.2590G>A	c.(2590-2592)Ggg>Agg	p.G864R	PPFIA2_ENST00000552948.1_Missense_Mutation_p.G864R|PPFIA2_ENST00000443686.3_Missense_Mutation_p.G765R|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000333447.7_Missense_Mutation_p.G846R|PPFIA2_ENST00000541017.1_Missense_Mutation_p.G81R|PPFIA2_ENST00000541570.2_Missense_Mutation_p.G431R|PPFIA2_ENST00000548586.1_Missense_Mutation_p.G864R|PPFIA2_ENST00000407050.4_Missense_Mutation_p.G790R|PPFIA2_ENST00000549325.1_Missense_Mutation_p.G846R|PPFIA2_ENST00000549396.1_Missense_Mutation_p.G864R|PPFIA2_ENST00000550359.2_Missense_Mutation_p.G711R	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	790										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TTGCCTAACCCCAGGGACTCC	0.408000													5	34					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56149081	56149081	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr18:56149081C>G	ENST00000361673.3	-	13	6700	c.6487G>C	c.(6487-6489)Gag>Cag	p.E2163Q		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	2163							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CCTGGGGTCTCAGGCCCTGCC	0.483000													14	64					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16534530	16534530	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:16534530C>T	ENST00000270747.3	-	3	739	c.603G>A	c.(601-603)ctG>ctA	p.L201L		NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	201					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		GCCGGGTCATCAGCTCCGATG	0.662000													6	35					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39425118	39425118	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:39425118C>T	ENST00000280481.7	+	10	6831	c.6615C>T	c.(6613-6615)gaC>gaT	p.D2205D		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2205	Calx-beta 4.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AGCTGATGGACGATGTGCTCT	0.478000													32	80					0	0	1	0	0
ADAP2	55803	broad.mit.edu	37	17	29276307	29276307	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:29276307G>A	ENST00000330889.3	+	7	995	c.660G>A	c.(658-660)gaG>gaA	p.E220E	ADAP2_ENST00000580525.1_Silent_p.E226E	NM_018404.2	NP_060874.1	Q9NPF8	ADAP2_HUMAN	ArfGAP with dual PH domains 2	220	PH 1.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						CTCCGCAGGAGATAGTGGACT	0.577000													7	56					0	0	1	0	0
GLDC	2731	broad.mit.edu	37	9	6550816	6550816	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:6550816G>A	ENST00000321612.6	-	21	2706	c.2556C>T	c.(2554-2556)ttC>ttT	p.F852F		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	852					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TTGCACCCCTGAAAAGAATTC	0.413000													27	172					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143090897	143090897	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:143090897G>A	ENST00000275815.3	-	16	2649	c.2563C>T	c.(2563-2565)Ctg>Ttg	p.L855L		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	855	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				AGCTCATACAGAGGGGCAGGG	0.587000													11	56					0	0	1	0	0
RALGPS1	9649	broad.mit.edu	37	9	129958857	129958857	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:129958857G>A	ENST00000259351.5	+	13	1409	c.1142G>A	c.(1141-1143)cGa>cAa	p.R381Q	RALGPS1_ENST00000373434.1_Intron|RALGPS1_ENST00000424082.2_Intron	NM_014636.2	NP_055451.1	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	381					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity	p.R381Q(1)		kidney(2)|large_intestine(6)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						CGCAGCCCCCGAAGGGGCCTG	0.577000													28	58					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124392379	124392379	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:124392379C>G	ENST00000338354.3	+	48	6089	c.5983C>G	c.(5983-5985)Cct>Gct	p.P1995A	DMBT1_ENST00000344338.3_Missense_Mutation_p.P1985A|DMBT1_ENST00000330163.4_Missense_Mutation_p.P1367A|DMBT1_ENST00000359586.6_Missense_Mutation_p.P715A|DMBT1_ENST00000368956.2_Missense_Mutation_p.P1367A|DMBT1_ENST00000368909.3_Missense_Mutation_p.P1995A|DMBT1_ENST00000368955.3_Missense_Mutation_p.P1985A			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1995					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTCAACAGCTCCTTTTCTCAA	0.498000													6	14					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878510	24878510	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:24878510G>C	ENST00000382554.3	+	4	1828	c.1510G>C	c.(1510-1512)Gat>Cat	p.D504H		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	504					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TATGCAGTTAGATTTTAAGGG	0.582000													3	39					0	0	1	0	0
FANCM	57697	broad.mit.edu	37	14	45605496	45605496	+	Missense_Mutation	SNP	A	A	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:45605496A>T	ENST00000267430.5	+	1	347	c.262A>T	c.(262-264)Aat>Tat	p.N88Y	FANCM_ENST00000556036.1_Missense_Mutation_p.N88Y|FANCM_ENST00000542564.2_Missense_Mutation_p.N88Y	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	88					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						TTACCCTACCAATTGCCCAGT	0.577000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				12	76					0	0	1	0	0
STX6	10228	broad.mit.edu	37	1	180959213	180959213	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:180959213C>G	ENST00000258301.5	-	5	633	c.396G>C	c.(394-396)tgG>tgC	p.W132C	STX6_ENST00000542060.1_Missense_Mutation_p.W31C	NM_005819.4	NP_005810.1	O43752	STX6_HUMAN	syntaxin 6	132					Golgi vesicle transport|intracellular protein transport|vesicle fusion	clathrin-coated vesicle|early endosome|integral to membrane|perinuclear region of cytoplasm|plasma membrane|trans-Golgi network membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	10						TTCCAGTGCTCCAGTTCTGGC	0.507000													36	96					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184041220	184041220	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:184041220C>T	ENST00000342981.4	+	14	2530	c.2116C>T	c.(2116-2118)Cag>Tag	p.Q706*	EIF4G1_ENST00000346169.2_Nonsense_Mutation_p.Q705*|EIF4G1_ENST00000350481.5_Nonsense_Mutation_p.Q541*|EIF4G1_ENST00000411531.1_Nonsense_Mutation_p.Q666*|EIF4G1_ENST00000392537.2_Nonsense_Mutation_p.Q618*|EIF4G1_ENST00000441154.1_Nonsense_Mutation_p.Q542*|EIF4G1_ENST00000382330.3_Nonsense_Mutation_p.Q712*|EIF4G1_ENST00000319274.6_Nonsense_Mutation_p.Q705*|EIF4G1_ENST00000352767.3_Nonsense_Mutation_p.Q712*|EIF4G1_ENST00000414031.1_Nonsense_Mutation_p.Q665*|EIF4G1_ENST00000427845.1_Nonsense_Mutation_p.Q619*|EIF4G1_ENST00000424196.1_Nonsense_Mutation_p.Q712*|EIF4G1_ENST00000434061.2_Nonsense_Mutation_p.Q510*|EIF4G1_ENST00000435046.2_Nonsense_Mutation_p.Q509*|EIF2B5_ENST00000444495.1_Intron	NM_182917.4	NP_886553	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	705	MIF4G.|eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCGGCGCTCTCAGCAGGGACC	0.517000													5	170					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57730567	57730567	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:57730567G>C	ENST00000281282.5	+	2	448	c.370G>C	c.(370-372)Gag>Cag	p.E124Q		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	124	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		CCTGCTCCATGAGGGCAAGAA	0.507000													10	72					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157502215	157502215	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:157502215G>C	ENST00000346085.5	+	12	3249	c.3248G>C	c.(3247-3249)aGa>aCa	p.R1083T	ARID1B_ENST00000350026.5_Missense_Mutation_p.R1070T|ARID1B_ENST00000478761.2_3'UTR|ARID1B_ENST00000275248.4_Missense_Mutation_p.R1065T|ARID1B_ENST00000367148.1_Missense_Mutation_p.R1123T	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1070	ARID.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		ATGGAAGAGAGAGGCTCTCCT	0.572000													7	28					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51254932	51254932	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:51254932C>T	ENST00000404971.1	-	2	1819	c.480G>A	c.(478-480)ccG>ccA	p.P160P	NRXN1_ENST00000402717.3_Silent_p.P160P|NRXN1_ENST00000406316.2_Silent_p.P160P|NRXN1_ENST00000405472.3_Silent_p.P160P|NRXN1_ENST00000405581.1_Silent_p.P160P|NRXN1_ENST00000401669.2_Silent_p.P160P|NRXN1_ENST00000406859.3_Silent_p.P160P	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	160	Laminin G-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity	p.P160P(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CGCGCAGTTCCGGGGGCAGCC	0.667000													12	17					0	0	1	0	0
TINAG	27283	broad.mit.edu	37	6	54173570	54173570	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:54173570C>T	ENST00000259782.4	+	1	318	c.222C>T	c.(220-222)ttC>ttT	p.F74F	TINAG_ENST00000370864.3_Silent_p.F56F|TINAG_ENST00000370869.3_Silent_p.F70F|TINAG_ENST00000486436.1_3'UTR	NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	74	SMB.				cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TCACTGAGTTCTATGCGGCGA	0.418000													47	133					0	0	1	0	0
FIP1L1	81608	broad.mit.edu	37	4	54257236	54257236	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:54257236G>T	ENST00000507166.1	+	8	566	c.566G>T	c.(565-567)tGt>tTt	p.C189F	FIP1L1_ENST00000337488.6_Missense_Mutation_p.C189F|FIP1L1_ENST00000306932.6_Missense_Mutation_p.C174F|FIP1L1_ENST00000507922.1_Missense_Mutation_p.C174F|FIP1L1_ENST00000358575.5_Missense_Mutation_p.C174F			Q6UN15	FIP1_HUMAN	factor interacting with PAPOLA and CPSF1	189	Necessary for stimulating PAPOLA activity.|Sufficient for interaction with CPSF4.				mRNA processing	nucleus	RNA binding			large_intestine(3)|liver(1)|ovary(1)|skin(1)	6			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			AAAGCTTACTGTGAAAAACAA	0.318000			T	PDGFRA	idiopathic hypereosinophilic syndrome								4	96					0.150653	0.151424	1	1	0
GDPD3	79153	broad.mit.edu	37	16	30122749	30122749	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:30122749C>T	ENST00000406256.3	-	7	1044	c.667G>A	c.(667-669)Gag>Aag	p.E223K		NM_024307.2	NP_077283.2	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain containing 3	223	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)	11						AAGAACTTCTCAGGGATTGGG	0.562000													20	130					0	0	1	0	0
NPY1R	4886	broad.mit.edu	37	4	164247358	164247358	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:164247358G>A	ENST00000296533.2	-	2	880	c.349C>T	c.(349-351)Cct>Tct	p.P117S	NPY1R_ENST00000509586.1_Intron	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	117					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGCACAAAAGGATTCAACTTA	0.453000													40	66					0	0	1	0	0
FER	2241	broad.mit.edu	37	5	108436119	108436119	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:108436119G>A	ENST00000281092.4	+	17	2331	c.1947G>A	c.(1945-1947)ctG>ctA	p.L649L	FER_ENST00000438717.2_Silent_p.L474L	NM_005246.2	NP_005237.2	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	649	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		TCACCTTTCTGAGAAGGAAGA	0.353000													15	83					0	0	1	0	0
HERC6	55008	broad.mit.edu	37	4	89304426	89304426	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:89304426G>C	ENST00000380265.5	+	2	436	c.253G>C	c.(253-255)Gag>Cag	p.E85Q	HERC6_ENST00000264346.7_Missense_Mutation_p.E85Q|HERC6_ENST00000273960.3_Missense_Mutation_p.E85Q	NM_001165136.1	NP_001158608.1	Q8IVU3	HERC6_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	85					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		CTGCGGGAAGGAGCACTCCCT	0.498000													5	12					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103311734	103311734	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:103311734G>C	ENST00000520539.1	-	24	3754	c.3148C>G	c.(3148-3150)Ctt>Gtt	p.L1050V	UBR5_ENST00000521922.1_Missense_Mutation_p.L1044V|UBR5_ENST00000220959.4_Missense_Mutation_p.L1050V	NM_001282873.1|NM_015902.5	NP_001269802.1|NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1050					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GCTGTGGTAAGAGATCCCACA	0.433000													6	38					0	0	1	0	0
SNRK	54861	broad.mit.edu	37	3	43388916	43388916	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:43388916C>T	ENST00000296088.7	+	7	1469	c.1165C>T	c.(1165-1167)Cag>Tag	p.Q389*	SNRK_ENST00000437827.1_Nonsense_Mutation_p.Q183*|SNRK_ENST00000429705.2_Nonsense_Mutation_p.Q389*|RP11-188P20.3_ENST00000607513.1_RNA|SNRK_ENST00000454177.1_Nonsense_Mutation_p.Q389*	NM_017719.4	NP_060189.3	Q9NRH2	SNRK_HUMAN	SNF related kinase	389					myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(5)|prostate(1)|skin(2)|stomach(1)	27				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		GACTGTCCCTCAGTCTCCTGC	0.552000													6	56					0	0	1	0	0
DUSP4	1846	broad.mit.edu	37	8	29195959	29195959	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:29195959C>T	ENST00000240100.2	-	3	1028	c.639G>A	c.(637-639)cgG>cgA	p.R213R	DUSP4_ENST00000240101.2_Silent_p.R122R	NM_001394.6	NP_001385.1	Q13115	DUS4_HUMAN	dual specificity phosphatase 4	213	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			endometrium(1)|large_intestine(1)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		GCATGTCTCTCCGGGCAGCAT	0.567000													5	34					0	0	1	0	0
BRPF3	27154	broad.mit.edu	37	6	36185777	36185777	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:36185777G>A	ENST00000357641.6	+	9	3326	c.3073G>A	c.(3073-3075)Gaa>Aaa	p.E1025K	BRPF3_ENST00000534400.1_Missense_Mutation_p.E1025K|BRPF3_ENST00000534694.1_Intron|BRPF3_ENST00000543502.1_Missense_Mutation_p.E755K|BRPF3_ENST00000339717.7_Missense_Mutation_p.E755K|BRPF3_ENST00000443324.2_Intron	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	1025					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						ACTGGCATTTGAAGCTTGCAG	0.493000													12	68					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533469	533469	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:533469G>T	ENST00000417302.1	-	4	621	c.434C>A	c.(433-435)tCg>tAg	p.S145*	HRAS_ENST00000451590.1_Nonsense_Mutation_p.S145*|HRAS_ENST00000311189.7_Nonsense_Mutation_p.S145*|HRAS_ENST00000397596.2_Nonsense_Mutation_p.S145*|HRAS_ENST00000397594.1_Nonsense_Mutation_p.S145*	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	145					activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding			adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GGTCTTGGCCGAGGTCTCGAT	0.677000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			10	57					0.000673444	0.000696483	1	1	0
TUBB8P7	197331	broad.mit.edu	37	16	90161578	90161578	+	RNA	SNP	G	G	A	rs13337896	by1000genomes	TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:90161578G>A	ENST00000564451.1	+	0	931				TUBB8P7_ENST00000567960.1_RNA														p.R105H(3)									GCCAAGGGACGCTACACCGAA	0.587000													3	54					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51771089	51771089	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:51771089G>C	ENST00000371117.3	-	41	7007	c.6732C>G	c.(6730-6732)ctC>ctG	p.L2244L	PKHD1_ENST00000340994.4_Silent_p.L2244L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2244					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CGCACATGCTGAGGCCTCTAC	0.428000													6	65					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107717510	107717510	+	Splice_Site	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:107717510C>T	ENST00000388781.3	-	17	2087		c.e17-1		LAMB4_ENST00000418464.1_Splice_Site|LAMB4_ENST00000414450.2_Splice_Site|LAMB4_ENST00000388780.3_Splice_Site|LAMB4_ENST00000205386.4_Splice_Site	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4						cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CAGCATGATTCTGTATTAAGA	0.383000													14	55					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096105	167096105	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:167096105G>C	ENST00000361200.2	+	6	1903	c.1737G>C	c.(1735-1737)aaG>aaC	p.K579N	DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.K579N|DUSP27_ENST00000443333.1_Missense_Mutation_p.K579N			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	579					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						TAGGGGAGAAGAACCCCTCCG	0.562000													10	54					0	0	1	0	0
ZNF747	65988	broad.mit.edu	37	16	30544281	30544281	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:30544281C>T	ENST00000569360.1	-	3	704	c.532G>A	c.(532-534)Gac>Aac	p.D178N	ZNF747_ENST00000568028.1_Missense_Mutation_p.D178N|ZNF747_ENST00000395094.3_3'UTR|ZNF747_ENST00000252799.3_3'UTR|ZNF747_ENST00000535210.1_Missense_Mutation_p.D178N			Q9BV97	ZN747_HUMAN	zinc finger protein 747	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding			kidney(1)|lung(3)|prostate(1)	5						TGACGCTGGTCAGCTCGGGGG	0.672000													3	14					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44640364	44640364	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:44640364C>T	ENST00000372330.3	+	6	994	c.975C>T	c.(973-975)ctC>ctT	p.L325L		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	325	Fibronectin type-II 2.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	GGGACAAGCTCTTCGGCTTCT	0.642000											OREG0025989	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	43					0	0	1	0	0
IMPACT	55364	broad.mit.edu	37	18	22020561	22020561	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr18:22020561G>C	ENST00000284202.4	+	6	610	c.469G>C	c.(469-471)Gat>Cat	p.D157H		NM_018439.3	NP_060909	Q9P2X3	IMPCT_HUMAN	impact RWD domain protein	157										endometrium(1)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(2)	16	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)					ATTGGATTTTGATATCAGTGA	0.358000													16	81					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5154274	5154274	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:5154274G>A	ENST00000252321.3	+	1	1190	c.961G>A	c.(961-963)Gcc>Acc	p.A321T		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	321						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						CAGGACCCTGGCCGACCCCTT	0.711000													13	61					0	0	1	0	0
SPARCL1	8404	broad.mit.edu	37	4	88414976	88414976	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:88414976C>T	ENST00000418378.1	-	5	1547	c.976G>A	c.(976-978)Gat>Aat	p.D326N	SPARCL1_ENST00000282470.6_Missense_Mutation_p.D326N|SPARCL1_ENST00000503414.1_Missense_Mutation_p.D201N	NM_001128310.1	NP_001121782.1	Q14515	SPRL1_HUMAN	SPARC-like 1 (hevin)	326					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(2)	21				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		TTACCATCATCAGTAGGTTCC	0.493000													32	179					0	0	1	0	0
EFTUD1	79631	broad.mit.edu	37	15	82431176	82431176	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:82431176G>A	ENST00000268206.7	-	19	3165	c.2997C>T	c.(2995-2997)gtC>gtT	p.V999V	EFTUD1_ENST00000359445.3_Silent_p.V948V	NM_024580.5	NP_078856.4	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain containing 1	999					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32						AGACAGCATAGACTCGACCTG	0.403000													21	57					0	0	1	0	0
LRRC14	9684	broad.mit.edu	37	8	145745822	145745822	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:145745822C>G	ENST00000292524.1	+	3	676	c.530C>G	c.(529-531)tCc>tGc	p.S177C	LRRC14_ENST00000529022.1_Missense_Mutation_p.S177C	NM_001272036.1|NM_014665.2	NP_001258965.1|NP_055480.1	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	177										endometrium(1)|lung(3)|prostate(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			AACCGGGCCTCCTATGCGTTC	0.711000													19	102					0	0	1	0	0
WRAP53	55135	broad.mit.edu	37	17	7606582	7606582	+	Silent	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:7606582C>G	ENST00000316024.5	+	10	3773	c.1425C>G	c.(1423-1425)ctC>ctG	p.L475L	WRAP53_ENST00000396463.2_Silent_p.L475L|WRAP53_ENST00000457584.2_Silent_p.L475L|WRAP53_ENST00000431639.2_Silent_p.L475L|WRAP53_ENST00000534050.1_Silent_p.L442L			Q9BUR4	WAP53_HUMAN	WD repeat containing, antisense to TP53	475					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(2)	18						GCCTGCCTCTCCTGGCCACTG	0.632000													12	46					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158906794	158906794	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:158906794G>C	ENST00000368140.1	+	2	339	c.94G>C	c.(94-96)Gat>Cat	p.D32H	PYHIN1_ENST00000392252.3_Missense_Mutation_p.D32H|PYHIN1_ENST00000392254.2_Missense_Mutation_p.D32H|PYHIN1_ENST00000368138.3_Missense_Mutation_p.D32H|PYHIN1_ENST00000368135.4_Missense_Mutation_p.D32H	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	32	DAPIN.				cell cycle	nuclear speck		p.D32N(3)		breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					ACTGAGTAACGATTTAAAACT	0.338000													5	72					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13228197	13228197	+	Missense_Mutation	SNP	T	T	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:13228197T>G	ENST00000378694.1	+	8	1207	c.1132T>G	c.(1132-1134)Tta>Gta	p.L378V	MCM10_ENST00000378714.3_Missense_Mutation_p.L378V|MCM10_ENST00000484800.2_Missense_Mutation_p.L379V			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	379					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						TCAGAAGGTCTTAATTATGGG	0.443000													25	215					0	0	1	0	0
OIP5	11339	broad.mit.edu	37	15	41605509	41605509	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:41605509C>T	ENST00000220514.3	-	4	615	c.556G>A	c.(556-558)Gat>Aat	p.D186N		NM_007280.1	NP_009211.1	O43482	MS18B_HUMAN	Opa interacting protein 5	186					cell communication|cell division|CenH3-containing nucleosome assembly at centromere|mitosis	Cajal body|chromatin|chromosome, centromeric region	protein binding			endometrium(3)|lung(1)|urinary_tract(1)	5		all_cancers(109;4.16e-14)|all_epithelial(112;7.09e-12)|Lung NSC(122;1.14e-09)|all_lung(180;2.56e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)		OV - Ovarian serous cystadenocarcinoma(18;1.49e-16)|GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.163)		TTTTGAATATCCATCTCTGAT	0.294000													13	76					0	0	1	0	0
RALGPS2	55103	broad.mit.edu	37	1	178871316	178871316	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:178871316G>C	ENST00000367635.3	+	18	1938	c.1600G>C	c.(1600-1602)Gat>Cat	p.D534H	RALGPS2_ENST00000367634.2_Missense_Mutation_p.D508H	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	534	PH.|Required for stimulation of nucleotide exchange by RALA (By similarity).				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						TGAACATCCTGATCTCTTCCT	0.393000													14	88					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8526502	8526502	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:8526502G>C	ENST00000360416.3	-	2	201	c.63C>G	c.(61-63)atC>atG	p.I21M	MYH10_ENST00000396239.1_Missense_Mutation_p.I21M|MYH10_ENST00000379980.4_Missense_Mutation_p.I21M|MYH10_ENST00000269243.4_Missense_Mutation_p.I21M	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	21	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CAGGGTTGTAGATGACAGCCC	0.478000													15	93					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44624540	44624540	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:44624540G>A	ENST00000415895.4	-	6	737	c.662C>T	c.(661-663)tCa>tTa	p.S221L	YIPF7_ENST00000332990.5_Missense_Mutation_p.S245L			Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7							endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						CTTGGAAGCTGAGAGACTACA	0.468000													8	29					0	0	1	0	0
EGR3	1960	broad.mit.edu	37	8	22548613	22548613	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:22548613G>C	ENST00000317216.2	-	2	894	c.537C>G	c.(535-537)gcC>gcG	p.A179A	EGR3_ENST00000522910.1_Silent_p.A141A|EGR3_ENST00000519492.1_3'UTR|RP11-459E5.1_ENST00000523627.1_RNA|EGR3_ENST00000524088.1_5'UTR	NM_001199881.1|NM_004430.2	NP_001186810.1|NP_004421.2	Q06889	EGR3_HUMAN	early growth response 3	179					circadian rhythm|muscle organ development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		Prostate(55;0.0421)|Breast(100;0.102)		Colorectal(74;0.0145)|BRCA - Breast invasive adenocarcinoma(99;0.053)|COAD - Colon adenocarcinoma(73;0.0608)		ACGCCGGCTTGGCCGATTGGT	0.602000													7	30					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40080465	40080465	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:40080465C>G	ENST00000336649.4	+	39	6007	c.6007C>G	c.(6007-6009)Ctg>Gtg	p.L2003V	CACNA1I_ENST00000400164.3_Missense_Mutation_p.L1962V|CACNA1I_ENST00000404898.1_Missense_Mutation_p.L1962V|CACNA1I_ENST00000402142.3_Missense_Mutation_p.L1997V|CACNA1I_ENST00000401624.1_Missense_Mutation_p.L1997V|CACNA1I_ENST00000407673.1_Missense_Mutation_p.L1962V			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1997					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CTGGGCATCTCTGCGGTCACC	0.622000													5	15					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	136960710	136960710	+	Translation_Start_Site	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:136960710G>C	ENST00000355845.4	-	0	379				MAP3K5_ENST00000359015.4_Missense_Mutation_p.I635M|RP3-325F22.3_ENST00000432477.1_RNA			Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5						activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TACAGAAATAGATTTGGAAAT	0.303000													7	13					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1616220	1616220	+	Silent	SNP	T	T	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:1616220T>C	ENST00000381580.1	-	4	854	c.675A>G	c.(673-675)caA>caG	p.Q225Q	SIRPG_ENST00000381583.2_Intron|RP11-77C3.3_ENST00000437384.1_RNA|SIRPG_ENST00000344103.4_Intron|SIRPG_ENST00000216927.4_Intron|SIRPG_ENST00000303415.3_Silent_p.Q258Q|RP11-77C3.3_ENST00000456177.1_RNA			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	258	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						TCATGGGCTGTTGAGTAACCT	0.542000													3	82					0	0	1	0	0
SUV420H1	51111	broad.mit.edu	37	11	67942494	67942494	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:67942494G>C	ENST00000304363.4	-	5	887	c.534C>G	c.(532-534)ttC>ttG	p.F178L	SUV420H1_ENST00000401547.2_Missense_Mutation_p.F178L|SUV420H1_ENST00000402185.2_Missense_Mutation_p.F155L|SUV420H1_ENST00000402789.1_Missense_Mutation_p.F178L|SUV420H1_ENST00000405515.1_Missense_Mutation_p.F178L	NM_017635.3	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						CATGTTCTTTGAATAATTTCT	0.318000													10	28					0	0	1	0	0
PWP2	5822	broad.mit.edu	37	21	45545908	45545908	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr21:45545908G>T	ENST00000291576.7	+	16	2109	c.1982G>T	c.(1981-1983)aGa>aTa	p.R661I	PWP2_ENST00000494310.1_3'UTR	NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	661						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		TTGAACCGAAGAAAAATGACA	0.542000													6	34					0.00116845	0.00120367	1	1	0
EID3	493861	broad.mit.edu	37	12	104698562	104698562	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:104698562G>C	ENST00000527879.1	+	1	1046	c.850G>C	c.(850-852)Gag>Cag	p.E284Q	TXNRD1_ENST00000503506.2_Intron|TXNRD1_ENST00000429002.2_Intron|TXNRD1_ENST00000397736.2_Intron|TXNRD1_ENST00000524698.1_Intron|TXNRD1_ENST00000526390.1_Intron|TXNRD1_ENST00000529546.1_Intron|TXNRD1_ENST00000354940.6_Intron|TXNRD1_ENST00000525566.1_Intron|TXNRD1_ENST00000526691.1_Intron|TXNRD1_ENST00000540716.1_Intron|TXNRD1_ENST00000542918.1_Intron|TXNRD1_ENST00000388854.3_Intron|TXNRD1_ENST00000378070.4_Intron	NM_001008394.2	NP_001008395.1	Q8N140	EID3_HUMAN	EP300 interacting inhibitor of differentiation 3	284					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						GCCAATATTAGAGCCGATGAA	0.378000													7	77					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123538964	123538964	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:123538964C>G	ENST00000422452.2	-	27	5371	c.5308G>C	c.(5308-5310)Gag>Cag	p.E1770Q	STAG2_ENST00000469481.1_Intron|TENM1_ENST00000371130.3_Missense_Mutation_p.E1763Q	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GCATTGTGCTCTCCGGGCAAT	0.547000													12	64					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5415970	5415970	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr18:5415970G>T	ENST00000341928.2	-	13	2254	c.1914C>A	c.(1912-1914)ttC>ttA	p.F638L	EPB41L3_ENST00000542652.2_Intron|EPB41L3_ENST00000544123.1_Intron|EPB41L3_ENST00000427684.2_Intron|EPB41L3_ENST00000542146.1_Intron|EPB41L3_ENST00000540638.2_Intron|EPB41L3_ENST00000342933.3_Missense_Mutation_p.F638L|EPB41L3_ENST00000400111.3_Intron	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	638	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						AGAAAAAGATGAAGAGGAAAC	0.562000													9	42					2.17888e-05	2.31745e-05	1	1	0
SERHL2	253190	broad.mit.edu	37	22	42968461	42968461	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:42968461G>A	ENST00000327678.5	+	11	853	c.751G>A	c.(751-753)Gat>Aat	p.D251N	SERHL2_ENST00000407614.4_Missense_Mutation_p.D71N|RRP7B_ENST00000357802.2_RNA|SERHL2_ENST00000340239.4_3'UTR|SERHL2_ENST00000335879.5_Missense_Mutation_p.D187N	NM_014509.3	NP_055324.2	Q9H4I8	SEHL2_HUMAN	serine hydrolase-like 2	251						perinuclear region of cytoplasm|peroxisome	hydrolase activity			breast(1)|endometrium(2)|lung(3)|skin(1)|stomach(1)	8						CGGATATTTTGATTCAAGACA	0.532000													15	98					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73048358	73048358	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:73048358C>T	ENST00000335350.6	+	7	1351	c.935C>T	c.(934-936)tCa>tTa	p.S312L	UNC5B_ENST00000373192.4_Missense_Mutation_p.S312L	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	312	TSP type-1 2.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						AGCAAGTGGTCAGCCTGCAGC	0.617000													12	96					0	0	1	0	0
TMTC4	84899	broad.mit.edu	37	13	101257282	101257282	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:101257282C>T	ENST00000342624.5	-	19	2507	c.2249G>A	c.(2248-2250)aGa>aAa	p.R750K	TMTC4_ENST00000328767.5_Missense_Mutation_p.R620K|TMTC4_ENST00000376234.3_Missense_Mutation_p.R731K	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	731						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTCTAGCTTTCTTCTCAGCAG	0.433000													20	139					0	0	1	0	0
TAF1D	79101	broad.mit.edu	37	11	93470346	93470346	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:93470346C>T	ENST00000448108.2	-	4	1169	c.519G>A	c.(517-519)ctG>ctA	p.L173L		NM_024116.3	NP_077021.1	Q9H5J8	TAF1D_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa	173					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			large_intestine(1)|lung(3)|prostate(1)|skin(2)	7						ATGATTCTTTCAGGTGGTGTT	0.303000													10	68					0	0	1	0	0
EIF3I	8668	broad.mit.edu	37	1	32690056	32690056	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:32690056G>C	ENST00000373586.1	+	4	302	c.230G>C	c.(229-231)cGt>cCt	p.R77P	EIF3I_ENST00000471486.1_3'UTR	NM_003757.2	NP_003748.1	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3, subunit I	77						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity	p.R77P(1)		breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				AACAGCTGTCGTCTCTGGGAC	0.473000													8	59					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95570330	95570330	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:95570330G>C	ENST00000526495.1	-	23	3694	c.3403C>G	c.(3403-3405)Caa>Gaa	p.Q1135E	DICER1_ENST00000343455.3_Missense_Mutation_p.Q1135E|DICER1_ENST00000541352.1_Missense_Mutation_p.Q1135E|DICER1_ENST00000556045.1_Missense_Mutation_p.Q33E|DICER1_ENST00000393063.1_Missense_Mutation_p.Q1135E|DICER1_ENST00000527414.1_Missense_Mutation_p.Q1135E			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1135					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TTAGCACCTTGATGTGCAGCA	0.418000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				15	51					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7875815	7875815	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:7875815G>C	ENST00000378789.3	-	5	829	c.778C>G	c.(778-780)Cat>Gat	p.H260D		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	260	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CGAGCCCCATGATTCGACACC	0.473000													38	65					0	0	1	0	0
FANCM	57697	broad.mit.edu	37	14	45605497	45605497	+	Missense_Mutation	SNP	A	A	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:45605497A>T	ENST00000267430.5	+	1	348	c.263A>T	c.(262-264)aAt>aTt	p.N88I	FANCM_ENST00000556036.1_Missense_Mutation_p.N88I|FANCM_ENST00000542564.2_Missense_Mutation_p.N88I	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	88					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						TACCCTACCAATTGCCCAGTG	0.582000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				12	76					0	0	1	0	0
SRCIN1	80725	broad.mit.edu	37	17	36717828	36717828	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:36717828C>T	ENST00000264659.7	-	7	1795	c.1571G>A	c.(1570-1572)gGa>gAa	p.G524E	SRCIN1_ENST00000398579.4_5'UTR|SRCIN1_ENST00000578925.1_Missense_Mutation_p.G558E	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	396	Interaction with SNAP25 (By similarity).				exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						GGTCTTCCCTCCAGGACTCTC	0.731000													3	13					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559118	140559118	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:140559118C>T	ENST00000239444.2	+	1	1748	c.1503C>T	c.(1501-1503)ctC>ctT	p.L501L		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		501	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCTGCCCCTCGCCTCCCTGG	0.672000													31	319					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15726550	15726550	+	RNA	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:15726550C>G	ENST00000441682.2	+	0	187							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CCTATGCCTTCTATCACAACG	0.672000													7	58					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144843165	144843165	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:144843165G>C	ENST00000367545.3	+	39	5591	c.5591G>C	c.(5590-5592)aGa>aCa	p.R1864T		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1864					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TCTGGAATTAGATCATCACTT	0.303000													13	82					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96051800	96051800	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:96051800G>C	ENST00000297954.4	+	20	4875	c.4875G>C	c.(4873-4875)ctG>ctC	p.L1625L	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000349097.3_Silent_p.L1237L|WNK2_ENST00000427277.2_Silent_p.L1200L|WNK2_ENST00000395477.2_Silent_p.L1588L|WNK2_ENST00000356055.3_5'UTR	NM_001282394.1	NP_001269323.1	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1625					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						TGGAGCCCCTGAGAGGGGACC	0.697000													7	10					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179290627	179290627	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:179290627C>T	ENST00000356834.3	-	22	3611	c.3574G>A	c.(3574-3576)Gtc>Atc	p.V1192I	TBC1D9B_ENST00000518085.1_5'UTR|TBC1D9B_ENST00000355235.3_Missense_Mutation_p.V1175I|TBC1D9B_ENST00000519746.1_Missense_Mutation_p.V351I|TBC1D9B_ENST00000444477.2_Missense_Mutation_p.V333I	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	1192						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCGGTGTCGACGGTGCCGCCG	0.622000													5	35					0	0	1	0	0
EPDR1	54749	broad.mit.edu	37	7	37960368	37960368	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:37960368C>T	ENST00000559325.1	+	1	206	c.187C>T	c.(187-189)Cgc>Tgc	p.R63C	EPDR1_ENST00000199448.4_5'UTR|EPDR1_ENST00000423717.1_5'UTR|EPDR1_ENST00000476620.1_Intron			Q9UM22	EPDR1_HUMAN	ependymin related 1	0					cell-matrix adhesion	extracellular region	calcium ion binding	p.R63C(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	22						TACCGGGACTCGCGCGTCCGG	0.672000													4	19					0	0	1	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204198202	204198202	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:204198202C>G	ENST00000272203.3	-	19	2930	c.2614G>C	c.(2614-2616)Gac>Cac	p.D872H	PLEKHA6_ENST00000414478.1_Missense_Mutation_p.D892H	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	872										breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TTGGAGATGTCTACCTCATGG	0.627000													4	31					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27255125	27255125	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:27255125G>A	ENST00000397501.1	+	7	832	c.24G>A	c.(22-24)ctG>ctA	p.L8L	PTK2B_ENST00000420218.2_Silent_p.L8L|PTK2B_ENST00000346049.5_Silent_p.L8L|PTK2B_ENST00000517339.1_Silent_p.L8L|PTK2B_ENST00000338238.4_Silent_p.L8L|PTK2B_ENST00000544172.1_Silent_p.L8L	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	8					apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CCGAGCCCCTGAGTCGAGTAA	0.592000													20	89					0	0	1	0	0
SMURF1	57154	broad.mit.edu	37	7	98655043	98655043	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:98655043C>G	ENST00000361125.1	-	4	654	c.335G>C	c.(334-336)gGa>gCa	p.G112A	SMURF1_ENST00000361368.2_Missense_Mutation_p.G112A|SMURF1_ENST00000480055.1_5'UTR	NM_020429.2	NP_065162.1	Q9HCE7	SMUF1_HUMAN	SMAD specific E3 ubiquitin protein ligase 1	112					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|urinary_tract(1)	25	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			GTTCTTACATCCGGTATCTTT	0.453000													4	84					0	0	1	0	0
ADAM8	101	broad.mit.edu	37	10	135084453	135084453	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:135084453G>A	ENST00000445355.3	-	14	1546	c.1496C>T	c.(1495-1497)tCc>tTc	p.S499F	ADAM8_ENST00000415217.3_Missense_Mutation_p.S499F|ADAM8_ENST00000485491.2_Missense_Mutation_p.S460F	NM_001109.4	NP_001100.3	B4DVM6	B4DVM6_HUMAN	ADAM metallopeptidase domain 8	460					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)	17		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		GTAGCCCCCGGAGCAGGGCGT	0.667000													6	36					0	0	1	0	0
NUDC	10726	broad.mit.edu	37	1	27272063	27272063	+	Nonsense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:27272063C>A	ENST00000321265.5	+	8	953	c.830C>A	c.(829-831)tCa>tAa	p.S277*	NUDC_ENST00000484772.1_3'UTR	NM_006600.3	NP_006591.1	Q9Y266	NUDC_HUMAN	nudC nuclear distribution protein	277					cell proliferation|cytokinesis|mitotic prometaphase|multicellular organismal development	cytosol|microtubule|nucleoplasm	protein binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|ovary(1)	8				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;6.1e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.87e-29)|Colorectal(126;5.74e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000281)|STAD - Stomach adenocarcinoma(196;0.000604)|KIRC - Kidney renal clear cell carcinoma(1967;0.000739)|READ - Rectum adenocarcinoma(331;0.0421)		CCTCAGCTGTCAGACCTGGAC	0.562000													11	46					0.000673444	0.000696483	1	1	0
PPP2R3C	55012	broad.mit.edu	37	14	35565970	35565970	+	Splice_Site	SNP	C	C	A	rs145714144		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:35565970C>A	ENST00000261475.5	-	8	1060	c.707G>T	c.(706-708)gGa>gTa	p.G236V		NM_017917.2	NP_060387.2	Q969Q6	P2R3C_HUMAN	protein phosphatase 2, regulatory subunit B'', gamma	236						centrosome|nucleus	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)	15	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)		TTTTATCTTTCCTTTAAGAAC	0.249000													17	54					4.7546e-09	5.21944e-09	1	1	0
KLHL22	84861	broad.mit.edu	37	22	20800943	20800943	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:20800943C>T	ENST00000328879.4	-	6	1482	c.1326G>A	c.(1324-1326)gcG>gcA	p.A442A	KLHL22_ENST00000440659.2_Silent_p.A299A	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	442					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CCTCCAGCGTCGCGCCTGCGT	0.587000													17	86					0	0	1	0	0
SLC10A7	84068	broad.mit.edu	37	4	147215230	147215230	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:147215230G>C	ENST00000432059.2	-	7	780	c.534C>G	c.(532-534)atC>atG	p.I178M	SLC10A7_ENST00000394062.3_Missense_Mutation_p.I191M|SLC10A7_ENST00000507030.1_Missense_Mutation_p.I191M|SLC10A7_ENST00000264986.3_3'UTR|SLC10A7_ENST00000335472.7_Missense_Mutation_p.I191M			Q0GE19	NTCP7_HUMAN	solute carrier family 10, member 7	191						integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(8)|skin(1)	16	all_hematologic(180;0.151)					GCCAATCCTTGATGTATCTTC	0.443000													7	20					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44888530	44888530	+	Missense_Mutation	SNP	G	G	C	rs138850981		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:44888530G>C	ENST00000261866.7	-	25	4201	c.4185C>G	c.(4183-4185)ttC>ttG	p.F1395L	SPG11_ENST00000558319.1_Missense_Mutation_p.F1395L|SPG11_ENST00000427534.2_Missense_Mutation_p.F1395L|SPG11_ENST00000535302.2_Missense_Mutation_p.F1395L	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	1395					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TGACTGGGCTGAAGTACTGGA	0.453000													13	70					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61623093	61623093	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:61623093G>C	ENST00000583023.1	+	14	2826	c.2815G>C	c.(2815-2817)Gag>Cag	p.E939Q	KCNH6_ENST00000581784.1_Missense_Mutation_p.E850Q|KCNH6_ENST00000314672.5_Missense_Mutation_p.E903Q|KCNH6_ENST00000456941.2_Missense_Mutation_p.E850Q	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	939					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	GGAACAGCCTGAGGGGCTCTG	0.582000													6	74					0	0	1	0	0
HIST4H4	121504	broad.mit.edu	37	12	14923708	14923708	+	Nonstop_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:14923708C>G	ENST00000539745.1	-	1	357	c.311G>C	c.(310-312)tGa>tCa	p.*104S		NM_175054.2	NP_778224.1	P62805	H4_HUMAN	histone cluster 4, H4	0					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)	6						GGGGACAGCTCAACCGCCGAA	0.547000											OREG0021698	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	48					0	0	1	0	0
KAZALD1	81621	broad.mit.edu	37	10	102822569	102822569	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:102822569G>A	ENST00000370200.5	+	2	546	c.220G>A	c.(220-222)Gac>Aac	p.D74N		NM_030929.4	NP_112191.2	Q96I82	KAZD1_HUMAN	Kazal-type serine peptidase inhibitor domain 1	74	Cys-rich.|IGFBP N-terminal.				cell differentiation|multicellular organismal development|ossification|regulation of cell growth		insulin-like growth factor binding			endometrium(1)|ovary(1)|prostate(2)	4				Epithelial(162;6.21e-09)|all cancers(201;3.14e-07)		CAGGGTGCGCGACGCGTGCGG	0.736000													4	33					0	0	1	0	0
UGT8	7368	broad.mit.edu	37	4	115544702	115544702	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:115544702C>T	ENST00000310836.6	+	2	1188	c.666C>T	c.(664-666)taC>taT	p.Y222Y	UGT8_ENST00000394511.3_Silent_p.Y222Y	NM_001128174.1	NP_001121646	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	222					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		TGCAGAAGTACAACCTGCTGC	0.463000													15	57					0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57982756	57982756	+	Silent	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:57982756C>G	ENST00000309433.6	+	1	540	c.540C>G	c.(538-540)ctC>ctG	p.L180L		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				TTCAATTGCTCTTCTGTAACC	0.453000													28	134					0	0	1	0	0
DHFR	1719	broad.mit.edu	37	5	79945222	79945222	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:79945222G>A	ENST00000439211.2	-	3	721	c.228C>T	c.(226-228)ctC>ctT	p.L76L	DHFR_ENST00000511032.1_Silent_p.L76L|DHFR_ENST00000505337.1_Silent_p.L76L|DHFR_ENST00000513048.1_5'UTR|DHFR_ENST00000504396.1_Silent_p.L24L	NM_000791.3	NP_000782.1	P00374	DYR_HUMAN	dihydrofolate reductase	76	DHFR.				folic acid metabolic process|glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to methotrexate|tetrahydrofolate metabolic process	cytosol	dihydrofolate reductase activity|drug binding|folate reductase activity|NADP binding			kidney(1)|large_intestine(1)	2		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.69e-46)|Epithelial(54;7.49e-41)|all cancers(79;1.54e-35)	Dapsone(DB00250)|Dimethyl sulfoxide(DB01093)|Lamotrigine(DB00555)|Methotrexate(DB00563)|NADH(DB00157)|Pemetrexed(DB00642)|Proguanil(DB01131)|Pyrimethamine(DB00205)|Trimethoprim(DB00440)|Trimetrexate(DB01157)	GTTCTCTGCTGAGAACTAAAT	0.333000													10	53					0	0	1	0	0
JSRP1	126306	broad.mit.edu	37	19	2254460	2254460	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:2254460G>C	ENST00000300961.6	-	3	195	c.131C>G	c.(130-132)tCc>tGc	p.S44C	JSRP1_ENST00000586471.2_Missense_Mutation_p.S44C	NM_144616.3	NP_653217.1	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1		Mediates interaction with CACNA1S (By similarity).					sarcoplasmic reticulum membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|pancreas(1)|urinary_tract(1)	6				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGCTGCCGGAGTCGGCCAG	0.657000													5	24					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	22					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105200108	105200108	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:105200108G>C	ENST00000369797.3	+	29	4304	c.4210G>C	c.(4210-4212)Gac>Cac	p.D1404H		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	1404					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TGGGAAGCCAGACGTGCTTTC	0.478000													16	75					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42531943	42531943	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr18:42531943G>A	ENST00000282030.5	+	4	2934	c.2638G>A	c.(2638-2640)Gac>Aac	p.D880N		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	880						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CAGCACTTCTGACCAAGCGGA	0.557000									Schinzel-Giedion syndrome				4	20					0	0	1	0	0
PHF6	84295	broad.mit.edu	37	X	133559262	133559262	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:133559262G>C	ENST00000332070.3	+	10	1202	c.1000G>C	c.(1000-1002)Gag>Cag	p.E334Q	PHF6_ENST00000370803.3_Missense_Mutation_p.E334Q|PHF6_ENST00000416404.2_Missense_Mutation_p.E300Q|PHF6_ENST00000394292.1_Missense_Mutation_p.E335Q	NM_032458.2	NP_115834.1	Q8IWS0	PHF6_HUMAN	PHD finger protein 6	334					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(88)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(1)|skin(1)|urinary_tract(1)	103	Acute lymphoblastic leukemia(192;0.000127)					TGGAAATGATGAGAGAGATGA	0.368000			"""F, N, Splice, Mis"""		ETP ALL								13	45					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90041535	90041535	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:90041535G>T	ENST00000405460.2	+	52	10993	c.10897G>T	c.(10897-10899)Gag>Tag	p.E3633*		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3633					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGGAGGAGCAGAGATTGGCAT	0.368000													9	35					0.00829132	0.00841987	1	1	0
KCNH2	3757	broad.mit.edu	37	7	150647216	150647216	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:150647216G>C	ENST00000430723.3	-	9	2450	c.2438C>G	c.(2437-2439)tCt>tGt	p.S813C	KCNH2_ENST00000392968.2_Intron|KCNH2_ENST00000262186.5_Intron|KCNH2_ENST00000330883.4_Intron	NM_172056.2	NP_742053.1	Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	0					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TGAGGCTGCAGAGGGCATTTC	0.612000													4	45					0	0	1	0	0
C12orf36	283422	broad.mit.edu	37	12	13526177	13526177	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:13526177C>T	ENST00000318426.2	-	3	595	c.378G>A	c.(376-378)gtG>gtA	p.V126V	C12orf36_ENST00000527705.2_Silent_p.V126V					chromosome 12 open reading frame 36											lung(3)|skin(3)	6				BRCA - Breast invasive adenocarcinoma(232;0.198)		ATTGATGCCTCACATCTTCCT	0.403000													16	109					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16981132	16981132	+	Missense_Mutation	SNP	T	T	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:16981132T>C	ENST00000377833.4	-	38	5628	c.5563A>G	c.(5563-5565)Aat>Gat	p.N1855D		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1855	CUB 13.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCCACAATATTATCATTGCCA	0.393000													11	66					0	0	1	0	0
CSE1L	1434	broad.mit.edu	37	20	47679743	47679743	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:47679743G>C	ENST00000262982.2	+	3	213	c.90G>C	c.(88-90)gaG>gaC	p.E30D	CSE1L_ENST00000542325.1_5'UTR|CSE1L_ENST00000396192.3_Missense_Mutation_p.E30D	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	30	Importin N-terminal.				apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TTACAGCTGAGAAATTTCTTG	0.274000													6	63					0	0	1	0	0
CRAT	1384	broad.mit.edu	37	9	131870321	131870321	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:131870321C>G	ENST00000318080.2	-	2	357	c.63G>C	c.(61-63)ttG>ttC	p.L21F	CRAT_ENST00000393384.3_Missense_Mutation_p.L21F|CRAT_ENST00000464290.1_5'UTR	NM_000755.3|NM_001257363.1	NP_000746|NP_001244292.1	P43155	CACP_HUMAN	carnitine O-acetyltransferase	21					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(2)	13				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	AAGCCTTCATCAAGGAGAAGG	0.627000													14	28					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82416756	82416756	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:82416756C>G	ENST00000370728.1	+	10	2192	c.1547C>G	c.(1546-1548)cCc>cGc	p.P516R	LPHN2_ENST00000370727.1_Missense_Mutation_p.P516R|LPHN2_ENST00000271029.4_Missense_Mutation_p.P516R|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370713.1_Missense_Mutation_p.P516R|LPHN2_ENST00000370715.1_Missense_Mutation_p.P516R|LPHN2_ENST00000319517.6_Missense_Mutation_p.P516R|LPHN2_ENST00000370721.1_Missense_Mutation_p.P454R|LPHN2_ENST00000370717.2_Missense_Mutation_p.P516R|LPHN2_ENST00000370730.1_Missense_Mutation_p.P516R|LPHN2_ENST00000394879.1_Missense_Mutation_p.P516R|LPHN2_ENST00000370725.1_Missense_Mutation_p.P516R|LPHN2_ENST00000370723.1_Missense_Mutation_p.P516R|LPHN2_ENST00000335786.5_Missense_Mutation_p.P516R|LPHN2_ENST00000359929.3_Missense_Mutation_p.P516R			O95490	LPHN2_HUMAN	latrophilin 2	516					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CCTAAGGGCCCCGATCTTAGC	0.423000													22	70					0	0	1	0	0
PXMP4	11264	broad.mit.edu	37	20	32295554	32295554	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:32295554G>C	ENST00000409299.3	-	4	689	c.597C>G	c.(595-597)atC>atG	p.I199M	PXMP4_ENST00000344022.3_3'UTR|PXMP4_ENST00000217398.3_3'UTR	NM_007238.4	NP_009169.3	Q9Y6I8	PXMP4_HUMAN	peroxisomal membrane protein 4, 24kDa	199						integral to membrane|membrane fraction|mitochondrial inner membrane|peroxisomal membrane	protein transporter activity			NS(1)|endometrium(2)|large_intestine(2)|lung(8)	13						GGAAGTCTGAGATGTCGTGCC	0.547000													32	126					0	0	1	0	0
EPC1	80314	broad.mit.edu	37	10	32581920	32581920	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:32581920C>G	ENST00000319778.6	-	4	964	c.662G>C	c.(661-663)cGa>cCa	p.R221P	EPC1_ENST00000375110.2_Missense_Mutation_p.R171P|EPC1_ENST00000263062.8_Missense_Mutation_p.R221P	NM_001272004.1|NM_001272019.2	NP_001258933.1|NP_001258948.1	Q9H2F5	EPC1_HUMAN	enhancer of polycomb homolog 1 (Drosophila)	221					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(5)|urinary_tract(1)	24		Prostate(175;0.0199)				ACTTACTTTTCGAGTCTGCAT	0.294000													20	47					0	0	1	0	0
DNAJC5B	85479	broad.mit.edu	37	8	67012265	67012265	+	Nonstop_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:67012265G>C	ENST00000276570.5	+	6	886	c.599G>C	c.(598-600)tGa>tCa	p.*200S	DNAJC5B_ENST00000519330.1_3'UTR	NM_033105.4	NP_149096.2	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	0					protein folding	membrane	heat shock protein binding|unfolded protein binding			endometrium(3)|large_intestine(6)|liver(1)|lung(6)|prostate(1)|skin(3)	20		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			ACAGACTCTTGATATTGAGCC	0.448000													5	35					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112364650	112364650	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:112364650C>G	ENST00000302475.4	-	16	2853	c.2290G>C	c.(2290-2292)Gat>Cat	p.D764H	MCC_ENST00000514701.3_5'UTR|MCC_ENST00000408903.3_Missense_Mutation_p.D954H|MCC_ENST00000515367.2_Missense_Mutation_p.D701H	NM_002387.2	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers	764					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		CGCTTTAGATCATTCACGAAC	0.522000													18	103					0	0	1	0	0
MICU1	10367	broad.mit.edu	37	10	74128016	74128016	+	Silent	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:74128016G>T	ENST00000398761.4	-	14	1506	c.1374C>A	c.(1372-1374)ctC>ctA	p.L458L	MICU1_ENST00000398763.4_Silent_p.L258L|MICU1_ENST00000418483.2_Silent_p.L258L|MICU1_ENST00000361114.5_Silent_p.L456L|MICU1_ENST00000401998.3_Silent_p.L456L			Q9BPX6	MICU1_HUMAN	mitochondrial calcium uptake 1	456					calcium ion import|defense response|elevation of mitochondrial calcium ion concentration	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding										TGGCCTGCATGAGGCGAGTGA	0.522000													5	31					3.59834e-05	3.81171e-05	1	1	0
GDPD3	79153	broad.mit.edu	37	16	30123468	30123468	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:30123468C>T	ENST00000406256.3	-	6	935	c.558G>A	c.(556-558)aaG>aaA	p.K186K		NM_024307.2	NP_077283.2	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain containing 3	186	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)	11						CCTTGCATTTCTTCATGACCG	0.622000													15	68					0	0	1	0	0
CAMTA2	23125	broad.mit.edu	37	17	4876139	4876139	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:4876139C>T	ENST00000361571.5	-	14	2836	c.2425G>A	c.(2425-2427)Gag>Aag	p.E809K	CAMTA2_ENST00000381311.5_Missense_Mutation_p.E812K|CAMTA2_ENST00000414043.3_Missense_Mutation_p.E833K|CAMTA2_ENST00000572543.1_Missense_Mutation_p.E815K|CAMTA2_ENST00000348066.3_Missense_Mutation_p.E810K|CAMTA2_ENST00000358183.4_Missense_Mutation_p.E810K	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	810					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						TGTAGTTCCTCAAGGCAGCGG	0.612000													39	135					0	0	1	0	0
POLR3A	11128	broad.mit.edu	37	10	79741237	79741237	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:79741237C>T	ENST00000372371.3	-	29	3977	c.3840G>A	c.(3838-3840)atG>atA	p.M1280I		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	1280					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			TGTCGATGCTCATGCCGTGGT	0.572000													60	227					0	0	1	0	0
GLYR1	84656	broad.mit.edu	37	16	4882142	4882142	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:4882142C>T	ENST00000321919.9	-	5	451	c.375G>A	c.(373-375)gaG>gaA	p.E125E	GLYR1_ENST00000436648.5_Intron|GLYR1_ENST00000591451.1_Silent_p.E125E|GLYR1_ENST00000381983.3_Silent_p.E125E|GLYR1_ENST00000586901.1_5'UTR	NM_032569.3	NP_115958	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	125					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						GTTTGCGCTTCTCATCACCTG	0.448000													25	98					0	0	1	0	0
NAB2	4665	broad.mit.edu	37	12	57485457	57485457	+	Silent	SNP	T	T	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:57485457T>C	ENST00000300131.3	+	2	1011	c.633T>C	c.(631-633)ccT>ccC	p.P211P	NAB2_ENST00000342556.6_Silent_p.P211P|NAB2_ENST00000554718.1_3'UTR|NAB2_ENST00000357680.4_Silent_p.P211P	NM_005967.3	NP_005958.1	Q15742	NAB2_HUMAN	NGFI-A binding protein 2 (EGR1 binding protein 2)	211					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity	p.P211P(3)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						TCTCCCCCCCTGCAGGGGGAG	0.711000													7	35					0	0	1	0	0
PRPH2	5961	broad.mit.edu	37	6	42689953	42689953	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:42689953G>A	ENST00000230381.5	-	1	359	c.120C>T	c.(118-120)ttC>ttT	p.F40F		NM_000322.4	NP_000313.2	P23942	PRPH2_HUMAN	peripherin 2 (retinal degeneration, slow)	40					cell adhesion|visual perception	integral to membrane				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	18	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			CAATCTTCAGGAACAGTCCTA	0.498000													14	77					0	0	1	0	0
CRTC3	64784	broad.mit.edu	37	15	91182020	91182020	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:91182020G>A	ENST00000420329.2	+	13	1668	c.1521G>A	c.(1519-1521)atG>atA	p.M507I	CRTC3_ENST00000268184.6_Missense_Mutation_p.M507I|RP11-387D10.2_ENST00000559531.1_RNA	NM_001042574.2|NM_022769.4	NP_001036039.1|NP_073606.3	Q6UUV7	CRTC3_HUMAN	CREB regulated transcription coactivator 3	507					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	breast(1)|endometrium(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			AGCAGTCCATGAGGCCAGGCC	0.488000			T	MAML2	salivary gland mucoepidermoid								9	54					0	0	1	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27887292	27887292	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:27887292G>A	ENST00000326019.6	+	1	955	c.673G>A	c.(673-675)Gac>Aac	p.D225N		NM_018158.2	NP_060628.2	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger), member 1, adaptor protein	225	FHA.					cytoplasm|nucleus	double-stranded RNA binding|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.155)					CGGAGAATGCGACAGCAACGG	0.622000													7	44					0	0	1	0	0
LONP1	9361	broad.mit.edu	37	19	5711790	5711790	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:5711790C>T	ENST00000360614.3	-	4	1019	c.862G>A	c.(862-864)Gag>Aag	p.E288K	LONP1_ENST00000540670.2_Missense_Mutation_p.E92K|LONP1_ENST00000590729.1_Intron|LONP1_ENST00000585374.1_Missense_Mutation_p.E174K|LONP1_ENST00000593119.1_Missense_Mutation_p.E224K	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	288	Lon.				cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ACTTTCACCTCCTCCGTGACC	0.667000													10	55					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179476135	179476135	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:179476135C>T	ENST00000589042.1	-	269	51045	c.50821G>A	c.(50821-50823)Gaa>Aaa	p.E16941K	TTN_ENST00000342992.6_Missense_Mutation_p.E14373K|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E7876K|TTN_ENST00000342175.6_Missense_Mutation_p.E8068K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E15300K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E8001K|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15300	Fibronectin type-III 23.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGAGATTTCAGATGGCTCG	0.388000													19	37					0	0	1	0	0
CCT6B	10693	broad.mit.edu	37	17	33259411	33259411	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:33259411G>T	ENST00000314144.5	-	11	1437	c.1322C>A	c.(1321-1323)gCt>gAt	p.A441D	CCT6B_ENST00000436961.3_Missense_Mutation_p.A396D|CCT6B_ENST00000421975.3_Missense_Mutation_p.A404D	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	441					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				TAAGGCATCAGCAAAAGCTTG	0.403000													29	170					2.48779e-11	2.76578e-11	1	1	0
VPS35	55737	broad.mit.edu	37	16	46697018	46697018	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:46697018G>A	ENST00000299138.7	-	14	1762	c.1704C>T	c.(1702-1704)atC>atT	p.I568I		NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)	568					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding	p.I568I(1)		breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TCAAAGCACTGATAGTCTGGT	0.363000													4	59					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192484	132192484	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:132192484G>A	ENST00000359827.3	-	2	1931	c.969C>T	c.(967-969)ggC>ggT	p.G323G	PLXNA4_ENST00000378539.5_Silent_p.G323G|PLXNA4_ENST00000321063.4_Silent_p.G323G|PLXNA4_ENST00000423507.2_Silent_p.G323G			Q9HCM2	PLXA4_HUMAN	plexin A4	323	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CAAGGGTCCTGCCAAGCACGG	0.592000													4	45					0	0	1	0	0
ZNF143	7702	broad.mit.edu	37	11	9496141	9496141	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:9496141G>C	ENST00000396602.2	+	5	453	c.334G>C	c.(334-336)Gaa>Caa	p.E112Q	ZNF143_ENST00000530463.1_Missense_Mutation_p.E111Q|ZNF143_ENST00000396604.1_Missense_Mutation_p.E111Q|ZNF143_ENST00000396597.3_Missense_Mutation_p.E81Q|ZNF143_ENST00000299606.2_Intron	NM_001282656.1|NM_001282657.1|NM_003442.5	NP_001269585.1|NP_001269586.1|NP_003433.3	P52747	ZN143_HUMAN	zinc finger protein 143	112					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding			endometrium(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	13				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		AGTACAGTTAGAAGATGGTAC	0.398000													8	62					0	0	1	0	0
MED15	51586	broad.mit.edu	37	22	20907444	20907444	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:20907444C>T	ENST00000263205.7	+	4	290	c.221C>T	c.(220-222)tCt>tTt	p.S74F	MED15_ENST00000425759.2_Missense_Mutation_p.S34F|MED15_ENST00000406969.1_Missense_Mutation_p.S48F|MED15_ENST00000541476.1_Missense_Mutation_p.S48F|MED15_ENST00000382974.2_Missense_Mutation_p.S74F|MED15_ENST00000542773.1_Intron|MED15_ENST00000292733.7_Missense_Mutation_p.S74F	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	74					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			AACAAGAAATCTCAAGCTTCC	0.363000													13	100					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	70992647	70992647	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:70992647C>T	ENST00000354624.5	+	3	487	c.354C>T	c.(352-354)atC>atT	p.I118I	HKDC1_ENST00000395086.2_Silent_p.I118I	NM_025130.3	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	118					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						CCAATGAAATCATCCGCGGGA	0.592000													14	81					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32911095	32911095	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:32911095C>T	ENST00000544455.1	+	11	2830	c.2603C>T	c.(2602-2604)aCt>aTt	p.T868I	BRCA2_ENST00000380152.3_Missense_Mutation_p.T868I	NM_000059.3	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	868	Interaction with NPM1.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GAAGAAACTACTTCAATTTCA	0.318000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			11	102					0	0	1	0	0
STX19	415117	broad.mit.edu	37	3	93733675	93733675	+	Missense_Mutation	SNP	T	T	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:93733675T>C	ENST00000315099.2	-	2	695	c.439A>G	c.(439-441)Atc>Gtc	p.I147V	ARL13B_ENST00000539730.1_Intron|ARL13B_ENST00000486562.1_Intron|ARL13B_ENST00000303097.7_Intron|ARL13B_ENST00000471138.1_Intron|ARL13B_ENST00000394222.3_Intron|ARL13B_ENST00000535334.1_Intron	NM_001001850.2	NP_001001850.1	Q8N4C7	STX19_HUMAN	syntaxin 19	147					intracellular protein transport|vesicle-mediated transport	membrane	SNAP receptor activity			kidney(2)|large_intestine(2)|lung(4)|prostate(1)	9						ATAAACATGATTTGCTGAAAA	0.373000													20	159					0	0	1	0	0
CPM	1368	broad.mit.edu	37	12	69250240	69250240	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:69250240G>C	ENST00000551568.1	-	9	1369	c.1309C>G	c.(1309-1311)Ctt>Gtt	p.L437V	CPM_ENST00000546373.1_Missense_Mutation_p.L437V|CPM_ENST00000338356.3_Missense_Mutation_p.L437V	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	437					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			ATGTGCAAAAGACTCACTAAA	0.408000													12	76					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143018586	143018586	+	Splice_Site	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:143018586G>C	ENST00000343257.2	+	4	649	c.562G>C	c.(562-564)Ggc>Cgc	p.G188R	CLCN1_ENST00000495612.1_3'UTR	NM_000083.2	NP_000074	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	188					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CCAGGCTGTTGGTGAGAACTT	0.632000													7	93					0	0	1	0	0
RXFP3	51289	broad.mit.edu	37	5	33937088	33937088	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:33937088G>A	ENST00000330120.3	+	1	598	c.243G>A	c.(241-243)cgG>cgA	p.R81R		NM_016568.3	NP_057652.1	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	81						integral to plasma membrane	N-formyl peptide receptor activity			endometrium(4)|large_intestine(9)|lung(24)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)	42						CCCGGGTGCGGATTCTCATCA	0.687000													6	54					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64518723	64518723	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:64518723G>C	ENST00000358025.3	+	48	8322	c.8092G>C	c.(8092-8094)Gaa>Caa	p.E2698Q	SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Missense_Mutation_p.E2698Q|SYNE2_ENST00000554584.1_Missense_Mutation_p.E2731Q	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2698					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GGGAGAAAAAGAAAAGAAGAA	0.393000													13	45					0	0	1	0	0
SETD8	387893	broad.mit.edu	37	12	123889520	123889520	+	Silent	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:123889520C>G	ENST00000402868.3	+	7	1173	c.747C>G	c.(745-747)ctC>ctG	p.L249L	SETD8_ENST00000330479.4_Silent_p.L249L			Q9NQR1	SETD8_HUMAN	SET domain containing (lysine methyltransferase) 8	290					cell division|mitosis|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(3)|urinary_tract(1)	13	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.00101)|Epithelial(86;0.00425)		ACGGGGACCTCATCGAGATCA	0.537000													13	71					0	0	1	0	0
C2CD2L	9854	broad.mit.edu	37	11	118982025	118982025	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:118982025G>C	ENST00000336702.3	+	6	1210	c.851G>C	c.(850-852)aGa>aCa	p.R284T	C2CD2L_ENST00000528586.1_Missense_Mutation_p.R32T	NM_014807.3	NP_055622.3	O14523	C2C2L_HUMAN	C2CD2-like	284						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)	13						GCCATCCCCAGACCTAACCGG	0.562000													57	101					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42820680	42820680	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:42820680G>A	ENST00000598766.1	+	9	766	c.766G>A	c.(766-768)Gat>Aat	p.D256N	TMEM145_ENST00000301204.3_Missense_Mutation_p.D232N			Q8NBT3	TM145_HUMAN	transmembrane protein 145	232			L -> M (in dbSNP:rs7254227).			integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				ATATGCCACCGATGGCATTGG	0.547000													30	200					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64418927	64418927	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:64418927G>A	ENST00000265459.6	-	14	3179	c.2718C>T	c.(2716-2718)ctC>ctT	p.L906L	AP001092.4_ENST00000433606.1_RNA|NRXN2_ENST00000409571.1_Silent_p.L899L|NRXN2_ENST00000377559.3_Silent_p.L866L|NRXN2_ENST00000377551.1_Silent_p.L906L	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	906					cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						AGCGAGCATTGAGCTCACAGT	0.587000											OREG0021057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	33					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5438044	5438044	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr18:5438044C>G	ENST00000341928.2	-	6	935	c.595G>C	c.(595-597)Gat>Cat	p.D199H	EPB41L3_ENST00000542652.2_Intron|EPB41L3_ENST00000544123.1_Missense_Mutation_p.D199H|EPB41L3_ENST00000540638.2_Missense_Mutation_p.D199H|EPB41L3_ENST00000342933.3_Missense_Mutation_p.D199H|EPB41L3_ENST00000400111.3_Missense_Mutation_p.D199H	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	199	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						CTGGTGATATCTTCAGATAGT	0.408000													6	21					0	0	1	0	0
TOP3A	7156	broad.mit.edu	37	17	18210208	18210208	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:18210208G>A	ENST00000321105.5	-	4	601	c.387C>T	c.(385-387)atC>atT	p.I129I	TOP3A_ENST00000542570.1_Silent_p.I34I	NM_004618.3	NP_004609.1	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	129	Toprim.				DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(2)|urinary_tract(1)	36						ACCCTACCTTGATGTCTACAA	0.403000													17	41					0	0	1	0	0
HSPA6	3310	broad.mit.edu	37	1	161494967	161494967	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:161494967G>A	ENST00000309758.4	+	1	932	c.519G>A	c.(517-519)cgG>cgA	p.R173R	RP11-25K21.6_ENST00000537821.2_RNA	NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	173			R -> P (in dbSNP:rs41297708).		response to unfolded protein		ATP binding			endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			ACGTGTTGCGGATCATCAATG	0.657000													13	26					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49420688	49420688	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:49420688G>A	ENST00000301067.7	-	48	15060	c.15061C>T	c.(15061-15063)Cga>Tga	p.R5021*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TTGTCAGGTCGCAAGGCTGTG	0.622000													12	76					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20760197	20760197	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:20760197C>G	ENST00000400451.2	+	5	1388	c.874C>G	c.(874-876)Ctg>Gtg	p.L292V	ZNF74_ENST00000356671.5_Missense_Mutation_p.L292V|ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000405993.1_Missense_Mutation_p.L260V	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	292					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CACCAACCTTCTGGAGCACCG	0.647000													11	78					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187524927	187524927	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:187524927G>A	ENST00000441802.2	-	19	10962	c.10753C>T	c.(10753-10755)Cag>Tag	p.Q3585*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3585	Cadherin 33.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTGTCCATCTGAGGGTCGAGA	0.488000										HNSCC(5;0.00058)			21	33					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49740124	49740124	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:49740124C>G	ENST00000327697.6	+	20	1832	c.1688C>G	c.(1687-1689)tCt>tGt	p.S563C	RNF123_ENST00000432042.1_Missense_Mutation_p.S417C	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	563						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CGGCTGATCTCTGCCCTGCGC	0.562000													86	191					0	0	1	0	0
KRTAP12-4	386684	broad.mit.edu	37	21	46074277	46074277	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr21:46074277G>A	ENST00000391618.1	-	1	299	c.255C>T	c.(253-255)ttC>ttT	p.F85F	TSPEAR_ENST00000323084.4_Intron	NM_198698.1	NP_941971.1	P60329	KR124_HUMAN	keratin associated protein 12-4	85	15 X 5 AA approximate repeats.					keratin filament				lung(4)|ovary(1)|prostate(1)	6						AGGTTGGGCAGAAGGAAGCCA	0.632000													7	45					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19365559	19365559	+	Silent	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:19365559G>T	ENST00000263208.5	-	14	1702	c.1446C>A	c.(1444-1446)atC>atA	p.I482I	HIRA_ENST00000546308.1_Silent_p.I438I|HIRA_ENST00000340170.4_Silent_p.I482I|HIRA_ENST00000541063.1_Silent_p.I438I	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	482	Interaction with CCNA1.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					CCGAGAGGGGGATGCTGTTAA	0.522000													10	78					2.74318e-10	3.02829e-10	1	1	0
DMXL2	23312	broad.mit.edu	37	15	51750971	51750971	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:51750971G>A	ENST00000251076.5	-	34	8232	c.7945C>T	c.(7945-7947)Cca>Tca	p.P2649S	RP11-707P17.2_ENST00000559977.1_RNA|RP11-707P17.2_ENST00000559173.1_RNA|DMXL2_ENST00000543779.2_Missense_Mutation_p.P2650S|DMXL2_ENST00000449909.3_Missense_Mutation_p.P2013S|RP11-707P17.2_ENST00000560727.1_RNA|RP11-707P17.1_ENST00000561007.1_RNA	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2649						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		TTTCCACCTGGATAGCCCAGA	0.373000													16	58					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89350709	89350709	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:89350709C>T	ENST00000301030.4	-	9	2701	c.2241G>A	c.(2239-2241)tcG>tcA	p.S747S	ANKRD11_ENST00000378330.2_Silent_p.S747S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	747	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTTCCTTCAGCGATCTCTCCT	0.393000													14	84					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31600295	31600295	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:31600295C>A	ENST00000376033.2	+	16	4079	c.3845C>A	c.(3844-3846)tCc>tAc	p.S1282Y	PRRC2A_ENST00000376007.4_Missense_Mutation_p.S1282Y	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	1282	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CTTCCAGCCTCCGCTCCTGGA	0.622000													13	54					5.50884e-06	5.89911e-06	1	1	0
KCNA2	3737	broad.mit.edu	37	1	111147017	111147017	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:111147017C>T	ENST00000485317.1	-	3	1061	c.388G>A	c.(388-390)Gaa>Aaa	p.E130K	KCNA2_ENST00000316361.4_Missense_Mutation_p.E130K|KCNA2_ENST00000440270.1_Missense_Mutation_p.E130K|KCNA2_ENST00000369770.3_Missense_Mutation_p.E130K|KCNA2_ENST00000525120.1_Intron			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	130						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		ATGTAGCCTTCATCTTCCCGA	0.483000													12	20					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68265217	68265217	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:68265217C>T	ENST00000347230.4	-	11	1900	c.1762G>A	c.(1762-1764)Gat>Aat	p.D588N	ZFYVE26_ENST00000555452.1_Missense_Mutation_p.D588N	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	588					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GGGTGAAGATCAGCAGAGGTG	0.517000													19	29					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187540591	187540591	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:187540591G>C	ENST00000441802.2	-	10	7358	c.7149C>G	c.(7147-7149)ctC>ctG	p.L2383L		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2383	Cadherin 21.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GATTATCATTGAGGTCGGTAA	0.502000										HNSCC(5;0.00058)			11	82					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57062286	57062286	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:57062286G>A	ENST00000436936.1	+	8	2457	c.2232G>A	c.(2230-2232)ctG>ctA	p.L744L	NLRC5_ENST00000539144.1_Silent_p.L744L|NLRC5_ENST00000262510.6_Silent_p.L744L|NLRC5_ENST00000308149.7_Silent_p.L744L			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	744					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				GTCCACAGCTGAAAGAAGTCA	0.562000													16	69					0	0	1	0	0
TCEA3	6920	broad.mit.edu	37	1	23710892	23710892	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:23710892C>T	ENST00000450454.2	-	10	1091	c.985G>A	c.(985-987)Gat>Aat	p.D329N		NM_003196.1	NP_003187.1	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	329					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		ATGGGCTCATCAGCACTGCGT	0.493000													13	83					0	0	1	0	0
DCAF11	80344	broad.mit.edu	37	14	24586196	24586196	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:24586196G>C	ENST00000446197.3	+	3	953	c.226G>C	c.(226-228)Gag>Cag	p.E76Q	DCAF11_ENST00000396941.4_Missense_Mutation_p.E50Q|DCAF11_ENST00000560171.1_Intron|DCAF11_ENST00000559115.1_Missense_Mutation_p.E76Q|DCAF11_ENST00000396936.1_5'UTR	NM_025230.4	NP_079506.3	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11	76						CUL4 RING ubiquitin ligase complex	protein binding										CTTGGACTCAGAGGAAGAGAA	0.493000													12	57					0	0	1	0	0
PDE4A	5141	broad.mit.edu	37	19	10531484	10531484	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:10531484C>T	ENST00000352831.6	+	1	154	c.44C>T	c.(43-45)tCa>tTa	p.S15L	PDE4A_ENST00000592685.1_Intron|PDE4A_ENST00000380702.2_Intron	NM_001111307.1	NP_001104777.1	P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	15					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CTGTCTCTGTCACTGCCCGGG	0.736000													3	10					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151921139	151921139	+	Missense_Mutation	SNP	C	C	G	rs141226447	byFrequency	TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:151921139C>G	ENST00000355193.2	-	20	3502	c.3284G>C	c.(3283-3285)aGa>aCa	p.R1095T	KMT2C_ENST00000262189.6_Missense_Mutation_p.R1095T					lysine (K)-specific methyltransferase 2C																		ATCTTCTTCTCTATAGTTTCG	0.363000													44	44					0	0	1	0	0
TRAV23DV6	28660	broad.mit.edu	37	14	22555189	22555189	+	RNA	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:22555189C>G	ENST00000390451.2	+	0	360																											cattgCATATCATGGATTCCC	0.478000													9	13					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126748790	126748790	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:126748790G>C	ENST00000251772.4	+	27	4944	c.4875G>C	c.(4873-4875)gaG>gaC	p.E1625D	PLXNA1_ENST00000393409.2_Missense_Mutation_p.E1648D			Q9UIW2	PLXA1_HUMAN	plexin A1	1648					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CCGACCTGGAGAGCGGCACCA	0.667000													12	45					0	0	1	0	0
OR14I1	401994	broad.mit.edu	37	1	248844975	248844975	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:248844975G>C	ENST00000342623.3	-	1	654	c.631C>G	c.(631-633)Ctc>Gtc	p.L211V		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						ATCATCATGAGAATAAAGCAT	0.493000													12	86					0	0	1	0	0
HIST1H2AH	85235	broad.mit.edu	37	6	27115132	27115132	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:27115132G>A	ENST00000377459.1	+	1	272	c.225G>A	c.(223-225)aaG>aaA	p.K75K		NM_080596.1	NP_542163.1	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	75					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|prostate(1)|skin(1)	12						GCGACAACAAGAAGACCCGTA	0.637000													17	109					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28654751	28654751	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr18:28654751C>T	ENST00000280904.6	-	12	2229	c.1786G>A	c.(1786-1788)Gcg>Acg	p.A596T	DSC2_ENST00000251081.6_Missense_Mutation_p.A596T	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	596	Cadherin 5.		A -> V.		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GGATCAACCGCAACAATCTCC	0.438000													12	41					0	0	1	0	0
DDX51	317781	broad.mit.edu	37	12	132624720	132624720	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:132624720C>T	ENST00000397333.3	-	12	1736	c.1698G>A	c.(1696-1698)gcG>gcA	p.A566A		NM_175066.3	NP_778236.2	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	566	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			endometrium(1)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		CGATGCCTCGCGCGGTGGCGT	0.711000													4	73					0	0	1	0	0
OR8G5	219865	broad.mit.edu	37	11	124135521	124135521	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:124135521G>A	ENST00000524943.2	+	1	799	c.799G>A	c.(799-801)Gag>Aag	p.E267K	OR8G1_ENST00000341493.2_RNA	NM_001005198.1	NP_001005198.1			olfactory receptor, family 8, subfamily G, member 5														Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0523)		TCGCTACACTGAGGGCAGGTC	0.488000													15	104					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58124279	58124279	+	Splice_Site	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:58124279C>T	ENST00000257897.3	-	12	1504	c.1419G>A	c.(1417-1419)acG>acA	p.T473T	AGAP2_ENST00000547588.1_Splice_Site_p.T809T	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	809	G domain.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding	p.T809T(1)|p.T473T(1)		breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						CCCACTGACCCGTGCTGAGGG	0.562000													134	219					0	0	1	0	0
EEF2	1938	broad.mit.edu	37	19	3977234	3977234	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:3977234G>A	ENST00000309311.6	-	14	2450	c.2362C>T	c.(2362-2364)Ctg>Ttg	p.L788L		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	788						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGACGGGCAGATAGGCCTTG	0.617000													6	16					0	0	1	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181968	128181968	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:128181968C>T	ENST00000469083.1	-	2	2678	c.121G>A	c.(121-123)Gag>Aag	p.E41K	DNAJB8_ENST00000319153.3_Missense_Mutation_p.E41K			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	41	J.				protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		TTCTCCGCCTCCTCCTTATTG	0.592000													42	118					0	0	1	0	0
CCNC	892	broad.mit.edu	37	6	100009278	100009278	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:100009278C>T	ENST00000520429.1	-	4	704	c.259G>A	c.(259-261)Gct>Act	p.A87T	CCNC_ENST00000518714.1_Missense_Mutation_p.A87T|CCNC_ENST00000521017.1_5'UTR|CCNC_ENST00000523985.1_Missense_Mutation_p.A2T|CCNC_ENST00000520371.1_Missense_Mutation_p.A87T|CCNC_ENST00000523799.1_Missense_Mutation_p.A2T|CCNC_ENST00000482541.2_Missense_Mutation_p.A87T|CCNC_ENST00000369220.4_Missense_Mutation_p.A87T	NM_001013399.1|NM_005190.3	NP_001013417.1|NP_005181.2	P24863	CCNC_HUMAN	cyclin C	87	Cyclin N-terminal.				regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	DNA-directed RNA polymerase II, holoenzyme	protein kinase binding						all_cancers(76;8.46e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.064)		CATGTAGGAGCCATTAATACA	0.318000													24	70					0	0	1	0	0
USP35	57558	broad.mit.edu	37	11	77924770	77924770	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:77924770G>A	ENST00000529308.1	+	11	3229	c.2968G>A	c.(2968-2970)Gat>Aat	p.D990N	USP35_ENST00000441408.2_Missense_Mutation_p.D576N|USP35_ENST00000530267.1_Missense_Mutation_p.D558N|USP35_ENST00000530535.1_3'UTR|USP35_ENST00000526425.1_Missense_Mutation_p.D721N	NM_020798.2	NP_065849.1	Q9P2H5	UBP35_HUMAN	ubiquitin specific peptidase 35	990					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(3)|urinary_tract(1)	23	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			GAGGGGCTTTGATGAAGACAA	0.587000													10	39					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24169144	24169144	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:24169144C>T	ENST00000396671.2	-	10	1338	c.990G>A	c.(988-990)ttG>ttA	p.L330L	THRB_ENST00000356447.4_Silent_p.L330L|THRB_ENST00000416420.1_Silent_p.L330L|THRB_ENST00000280696.5_Silent_p.L345L	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	330	Interaction with NR2F6.|Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	TTTCCCCATTCAAGGTTAAAG	0.527000													50	101					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107688370	107688370	+	Missense_Mutation	SNP	G	G	A	rs140847960		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:107688370G>A	ENST00000388781.3	-	28	4392	c.4309C>T	c.(4309-4311)Cgt>Tgt	p.R1437C	LAMB4_ENST00000388780.3_Missense_Mutation_p.R1437C|LAMB4_ENST00000205386.4_Missense_Mutation_p.R1437C	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1437	Domain I.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TTCAACCCACGAACCTGTTTG	0.403000													24	136					0	0	1	0	0
TCF7	6932	broad.mit.edu	37	5	133473792	133473792	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:133473792C>T	ENST00000395029.1	+	4	679	c.484C>T	c.(484-486)Ctc>Ttc	p.L162F	TCF7_ENST00000342854.5_Missense_Mutation_p.L162F|TCF7_ENST00000432532.2_Missense_Mutation_p.L47F|TCF7_ENST00000520958.1_Missense_Mutation_p.L47F|TCF7_ENST00000378564.1_Missense_Mutation_p.L162F|TCF7_ENST00000321603.6_Missense_Mutation_p.L162F|TCF7_ENST00000321584.4_Missense_Mutation_p.L162F|TCF7_ENST00000518915.1_Missense_Mutation_p.L47F|TCF7_ENST00000395023.1_Missense_Mutation_p.L47F|TCF7_ENST00000378560.4_Missense_Mutation_p.L47F			P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific, HMG-box)	162					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding			kidney(2)|large_intestine(7)|lung(2)|skin(1)	12		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCAACTCTCTCTCTACGAACA	0.587000													9	49					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	368979	368979	+	Silent	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:368979C>A	ENST00000436453.1	-	2	292	c.240G>T	c.(238-240)ctG>ctT	p.L80L	SLC6A13_ENST00000445055.2_Intron|SLC6A13_ENST00000343164.4_Intron	NM_001243392.1	NP_001230321.1	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	0					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			ATCCTCCTTCCAGGAGTGGGT	0.532000													9	91					0.000274275	0.000286295	1	1	0
DICER1	23405	broad.mit.edu	37	14	95596491	95596491	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:95596491C>G	ENST00000526495.1	-	7	768	c.477G>C	c.(475-477)ttG>ttC	p.L159F	DICER1_ENST00000343455.3_Missense_Mutation_p.L159F|DICER1_ENST00000541352.1_Missense_Mutation_p.L159F|DICER1_ENST00000393063.1_Missense_Mutation_p.L159F|DICER1_ENST00000527414.1_Missense_Mutation_p.L159F			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	159	Helicase ATP-binding.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AACCATTTTTCAAAACATTCA	0.348000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				7	41					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75115901	75115901	+	Splice_Site	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:75115901G>A	ENST00000309664.5	+	12	1340	c.1201G>A	c.(1201-1203)Gat>Aat	p.D401N	LMAN1L_ENST00000379709.3_Splice_Site_p.D389N|RP11-414J4.2_ENST00000564823.1_RNA	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	401						ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding	p.D401N(1)		NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCCGGTTAGGGATGCAGCTGT	0.552000													3	35					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98766408	98766408	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:98766408C>G	ENST00000266058.4	-	32	3656	c.3411G>C	c.(3409-3411)caG>caC	p.Q1137H	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Missense_Mutation_p.Q1137H	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1137	EGF-like 6.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TGGCCCCATTCTGGCACTCAG	0.597000													5	26					0	0	1	0	0
ZFYVE19	84936	broad.mit.edu	37	15	41105033	41105033	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:41105033G>A	ENST00000355341.4	+	7	1464	c.963G>A	c.(961-963)acG>acA	p.T321T	ZFYVE19_ENST00000570108.1_Silent_p.T298T|ZFYVE19_ENST00000299173.10_Intron|ZFYVE19_ENST00000564258.1_Silent_p.T146T|ZFYVE19_ENST00000336455.5_Silent_p.T311T	NM_001077268.1	NP_001070736.1	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	321							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		AGGAGAACACGAGGCAGGAAC	0.612000													17	60					0	0	1	0	0
PRPF18	8559	broad.mit.edu	37	10	13672265	13672265	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:13672265G>C	ENST00000378572.3	+	10	1114	c.954G>C	c.(952-954)ttG>ttC	p.L318F		NM_003675.3	NP_003666.1	Q99633	PRP18_HUMAN	pre-mRNA processing factor 18	318					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(5)|prostate(1)	17						CTTAGGGATTGAAGAGGTTAA	0.388000													15	132					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158924856	158924856	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:158924856G>C	ENST00000367097.3	+	13	5518	c.4161G>C	c.(4159-4161)caG>caC	p.Q1387H	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	1387					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		TGAAGAGTCAGAAAGACCAAC	0.488000													9	20					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46946348	46946348	+	Nonsense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:46946348G>C	ENST00000429979.1	-	3	867	c.263C>G	c.(262-264)tCa>tGa	p.S88*	KIAA0226L_ENST00000409879.2_Intron|KIAA0226L_ENST00000378781.3_Nonsense_Mutation_p.S88*|KIAA0226L_ENST00000378797.2_Nonsense_Mutation_p.S88*|KIAA0226L_ENST00000378784.4_Intron|KIAA0226L_ENST00000480935.1_Intron|KIAA0226L_ENST00000389908.3_Nonsense_Mutation_p.S88*|KIAA0226L_ENST00000322896.6_Intron|KIAA0226L_ENST00000534925.1_Intron|KIAA0226L_ENST00000378787.3_Nonsense_Mutation_p.S88*	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	88	Ser-rich.									NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						TGAAGGGCCTGAGGGAGAGGC	0.597000													6	89					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	61					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55681570	55681570	+	Silent	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:55681570G>T	ENST00000344514.1	-	1	488	c.489C>A	c.(487-489)gcC>gcA	p.A163A		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	163			A -> P (in dbSNP:rs17148883).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						ATAGGCGGAAGGCCAGTGTCA	0.433000													8	84					0.000157383	0.000164499	1	1	0
SMG8	55181	broad.mit.edu	37	17	57288157	57288157	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:57288157C>G	ENST00000543872.2	+	2	1009	c.745C>G	c.(745-747)Cca>Gca	p.P249A	SMG8_ENST00000578922.1_Missense_Mutation_p.P249A|CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000300917.5_Missense_Mutation_p.P249A|SMG8_ENST00000580498.1_Intron			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	249					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						TAAGGATTGTCCAGTTGGCAA	0.488000													22	65					0	0	1	0	0
ZNF800	168850	broad.mit.edu	37	7	127014080	127014080	+	Nonsense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:127014080G>C	ENST00000393313.1	-	5	1901	c.1310C>G	c.(1309-1311)tCa>tGa	p.S437*	ZNF800_ENST00000265827.3_Nonsense_Mutation_p.S437*|ZNF800_ENST00000393312.1_Nonsense_Mutation_p.S437*			Q2TB10	ZN800_HUMAN	zinc finger protein 800	437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						TTTTTCATTTGAATGATTTGT	0.398000													21	102					0	0	1	0	0
ZNF747	65988	broad.mit.edu	37	16	30544249	30544249	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:30544249C>G	ENST00000569360.1	-	3	736	c.564G>C	c.(562-564)aaG>aaC	p.K188N	ZNF747_ENST00000568028.1_Missense_Mutation_p.K188N|ZNF747_ENST00000395094.3_3'UTR|ZNF747_ENST00000252799.3_3'UTR|ZNF747_ENST00000535210.1_Missense_Mutation_p.K188N			Q9BV97	ZN747_HUMAN	zinc finger protein 747	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding			kidney(1)|lung(3)|prostate(1)	5						AGGCGAAGCTCTTCCCGCACA	0.672000													3	12					0	0	1	0	0
UTS2	10911	broad.mit.edu	37	1	7907868	7907868	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:7907868C>G	ENST00000377516.2	-	5	653	c.333G>C	c.(331-333)aaG>aaC	p.K111N	UTS2_ENST00000054668.5_Missense_Mutation_p.K126N|UTS2_ENST00000361696.5_Missense_Mutation_p.K111N			O95399	UTS2_HUMAN	urotensin 2	111					muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity			kidney(1)|lung(4)|urinary_tract(1)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		TCTCACGTTTCTTGTATGGTT	0.373000													24	114					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110399113	110399113	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:110399113G>C	ENST00000360185.4	-	11	1121	c.957C>G	c.(955-957)gtC>gtG	p.V319V	GIT2_ENST00000356259.4_Silent_p.V319V|GIT2_ENST00000457474.2_Silent_p.V321V|GIT2_ENST00000343646.5_Silent_p.V319V|TCHP_ENST00000550780.1_Intron|GIT2_ENST00000320063.9_Silent_p.V319V|GIT2_ENST00000355312.3_Silent_p.V319V|GIT2_ENST00000338373.5_Silent_p.V319V|GIT2_ENST00000551209.1_Silent_p.V318V|GIT2_ENST00000553118.1_Silent_p.V319V|GIT2_ENST00000361006.5_Silent_p.V319V|GIT2_ENST00000354574.4_Silent_p.V321V|GIT2_ENST00000547815.1_Silent_p.V319V	NM_014776.3	NP_055591.2	Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	319					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						ACTCAGGATTGACCGGAAGAA	0.498000													17	31					0	0	1	0	0
CYP24A1	1591	broad.mit.edu	37	20	52774034	52774034	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:52774034C>G	ENST00000216862.3	-	10	1720	c.1327G>C	c.(1327-1329)Gag>Cag	p.E443Q	CYP24A1_ENST00000395954.3_Missense_Mutation_p.E301Q|CYP24A1_ENST00000395955.3_Intron	NM_000782.4	NP_000773.2	Q07973	CP24A_HUMAN	cytochrome P450, family 24, subfamily A, polypeptide 1	443					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	TTTTCCTTCTCCTGAAGCCAA	0.423000													11	130					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137506827	137506827	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:137506827C>G	ENST00000254900.5	-	5	630	c.259G>C	c.(259-261)Gaa>Caa	p.E87Q	BRD8_ENST00000402931.1_Missense_Mutation_p.E87Q|BRD8_ENST00000455658.2_Missense_Mutation_p.E46Q|BRD8_ENST00000411594.2_Missense_Mutation_p.E87Q|BRD8_ENST00000230901.5_Missense_Mutation_p.E87Q	NM_139199.1	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	87					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TCCACCACTTCTCCCTTTTCA	0.363000													15	60					0	0	1	0	0
UNK	85451	broad.mit.edu	37	17	73811302	73811302	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:73811302G>T	ENST00000293218.3	+	8	1157	c.1157G>T	c.(1156-1158)cGa>cTa	p.R386L	UNK_ENST00000589666.1_Missense_Mutation_p.R310L			Q9C0B0	UNK_HUMAN	unkempt family zinc finger	310							nucleic acid binding|zinc ion binding	p.R310L(1)|p.R386L(1)		cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGCTGTCCCCGAGGACCCTTC	0.637000													11	138					1.58986e-06	1.71417e-06	1	1	0
FGB	2244	broad.mit.edu	37	4	155487089	155487089	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:155487089C>G	ENST00000302068.4	+	2	307	c.244C>G	c.(244-246)Caa>Gaa	p.Q82E	FGB_ENST00000509493.1_Intron|FGB_ENST00000502545.1_3'UTR	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	82			Missing (in New York-1).		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AGCTGCCACTCAAAAGAAAGT	0.577000													12	36					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98744149	98744149	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:98744149G>C	ENST00000286067.2	+	1	3109	c.3002G>C	c.(3001-3003)aGa>aCa	p.R1001T		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	1001										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CGGATTCTTAGAAAATATTCC	0.468000													3	82					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76344739	76344739	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:76344739C>G	ENST00000263187.3	+	12	1707	c.1603C>G	c.(1603-1605)Cga>Gga	p.R535G		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	535					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						TAGCTCTGCTCGAGGATTTTT	0.343000								Mismatch excision repair (MMR)					7	60					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81239618	81239618	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:81239618C>T	ENST00000552864.1	-	4	576	c.374G>A	c.(373-375)gGa>gAa	p.G125E		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	125	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						TTGCTCCTTTCCTCCCATCAC	0.498000													15	56					0	0	1	0	0
NEK7	140609	broad.mit.edu	37	1	198262152	198262152	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:198262152G>A	ENST00000367385.4	+	8	1009	c.667G>A	c.(667-669)Ggc>Agc	p.G223S	NEK7_ENST00000538004.1_Missense_Mutation_p.G223S	NM_133494.2	NP_598001.1	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	223	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21						CTGGTCTCTTGGCTGTCTACT	0.318000													38	149					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28913402	28913402	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:28913402C>T	ENST00000395503.4	+	16	2503	c.2319C>T	c.(2317-2319)gtC>gtT	p.V773V	ATP2A1_ENST00000536376.1_Silent_p.V648V|ATP2A1_ENST00000357084.3_Silent_p.V773V	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	773					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						GCGAGGTGGTCTGGTGAGCAG	0.622000													7	33					0	0	1	0	0
SCAF4	57466	broad.mit.edu	37	21	33068523	33068523	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr21:33068523C>G	ENST00000286835.7	-	9	1353	c.971G>C	c.(970-972)gGa>gCa	p.G324A	SCAF4_ENST00000434667.3_Missense_Mutation_p.G309A|SCAF4_ENST00000399804.1_Missense_Mutation_p.G324A	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	324						nucleus	nucleotide binding|RNA binding	p.G324V(1)		NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						CATGCCATCTCCAGGAAAGCC	0.423000													26	105					0	0	1	0	0
ING2	3622	broad.mit.edu	37	4	184431485	184431485	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:184431485G>A	ENST00000302327.3	+	2	425	c.223G>A	c.(223-225)Gat>Aat	p.D75N	ING2_ENST00000434682.2_Missense_Mutation_p.D35N	NM_001564.2	NP_001555.1	Q9H160	ING2_HUMAN	inhibitor of growth family, member 2	75					chromatin modification|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of growth|signal transduction|transcription, DNA-dependent	CCAAT-binding factor complex|Sin3 complex	chromatin binding|DNA binding|protein complex binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)	7		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|all_hematologic(60;0.0207)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GAAAGAAGATGATTTAAACCA	0.323000													68	92					0	0	1	0	0
GCFC2	6936	broad.mit.edu	37	2	75929431	75929431	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:75929431C>G	ENST00000321027.3	-	3	646	c.513G>C	c.(511-513)aaG>aaC	p.K171N	GCFC2_ENST00000409857.3_Intron|GCFC2_ENST00000470503.1_Missense_Mutation_p.K171N|GCFC2_ENST00000541687.1_Missense_Mutation_p.K171N	NM_001201334.1|NM_003203.4	NP_001188263.1|NP_003194.3	P16383	GCF_HUMAN	GC-rich sequence DNA-binding factor 2	171					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.K171K(1)									CGCTCTCTCTCTTCATACCAG	0.453000													50	54					0	0	1	0	0
PTGER4	5734	broad.mit.edu	37	5	40681608	40681608	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:40681608C>A	ENST00000302472.3	+	2	1537	c.513C>A	c.(511-513)ttC>ttA	p.F171L	PTGER4_ENST00000514343.1_3'UTR	NM_000958.2	NP_000949.1	P35408	PE2R4_HUMAN	prostaglandin E receptor 4 (subtype EP4)	171					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						CCTGGTGCTTCATCGACTGGA	0.607000													11	46					1.08611e-07	1.17587e-07	1	1	0
NOTCH4	4855	broad.mit.edu	37	6	32169124	32169124	+	Silent	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:32169124C>A	ENST00000375023.3	-	22	4047	c.3909G>T	c.(3907-3909)ctG>ctT	p.L1303L		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1303					cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						CTGGGGGGCTCAGTACCACCA	0.642000													8	26					0.00307968	0.00314776	1	1	0
SLC41A2	84102	broad.mit.edu	37	12	105282953	105282953	+	Silent	SNP	A	A	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:105282953A>T	ENST00000258538.3	-	4	865	c.738T>A	c.(736-738)gtT>gtA	p.V246V		NM_032148.3	NP_115524.3	Q96JW4	S41A2_HUMAN	solute carrier family 41 (magnesium transporter), member 2	246						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	22						CTGTTGCCTGAACCTAAAATT	0.308000													10	53					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157669493	157669493	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:157669493C>G	ENST00000368184.3	-	3	332	c.41G>C	c.(40-42)aGa>aCa	p.R14T	FCRL3_ENST00000368186.5_Missense_Mutation_p.R14T	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	14						integral to membrane|plasma membrane	receptor activity	p.R14K(1)		autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					TGATTGTTCTCTTCCAGGAGC	0.478000													5	43					0	0	1	0	0
CCDC144CP	348254	broad.mit.edu	37	17	20239263	20239263	+	RNA	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:20239263C>T	ENST00000340196.4	+	0	687																											AGTCAGCAACCAAAGAACTGG	0.428000													37	72					0	0	1	0	0
WDR36	134430	broad.mit.edu	37	5	110432815	110432815	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:110432815G>A	ENST00000506538.2	+	3	970	c.397G>A	c.(397-399)Gat>Aat	p.D133N	WDR36_ENST00000505303.1_Missense_Mutation_p.D77N|WDR36_ENST00000513710.2_Missense_Mutation_p.D133N	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	133					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		TATGGCAGCTGATGGCAGATT	0.373000													11	64					0	0	1	0	0
HIST1H3F	8968	broad.mit.edu	37	6	26250797	26250797	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:26250797C>T	ENST00000446824.2	-	1	38	c.37G>A	c.(37-39)Ggc>Agc	p.G13S		NM_021018.2	NP_066298.1	P68431	H31_HUMAN	histone cluster 1, H3f	13					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			lung(6)|urinary_tract(1)	7						GCTTTGCCGCCAGTGGACTTA	0.557000													7	70					0	0	1	0	0
DBNDD2	55861	broad.mit.edu	37	20	44037124	44037124	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:44037124G>A	ENST00000372712.2	+	2	598	c.17G>A	c.(16-18)cGg>cAg	p.R6Q	SYS1-DBNDD2_ENST00000452133.1_3'UTR|DBNDD2_ENST00000357275.2_Missense_Mutation_p.R6Q|DBNDD2_ENST00000372723.3_Missense_Mutation_p.R6Q|SYS1-DBNDD2_ENST00000475242.1_3'UTR|DBNDD2_ENST00000372710.3_Missense_Mutation_p.R108Q|DBNDD2_ENST00000372722.3_Missense_Mutation_p.R6Q|DBNDD2_ENST00000372717.1_Missense_Mutation_p.R6Q|DBNDD2_ENST00000372720.3_Missense_Mutation_p.R104Q|DBNDD2_ENST00000360981.4_Missense_Mutation_p.R6Q			Q9BQY9	DBND2_HUMAN	dysbindin (dystrobrevin binding protein 1) domain containing 2	104					negative regulation of protein kinase activity	cytoplasm	protein binding			breast(1)|lung(2)	3		Myeloproliferative disorder(115;0.0122)				CCAAATCCTCGGGCCGCCCTG	0.572000													11	122					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103453263	103453263	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:103453263C>A	ENST00000358392.2	-	30	2781	c.2464G>T	c.(2464-2466)Gat>Tat	p.D822Y	COL11A1_ENST00000353414.4_Missense_Mutation_p.D771Y|COL11A1_ENST00000370096.3_Missense_Mutation_p.D810Y|COL11A1_ENST00000512756.1_Missense_Mutation_p.D694Y	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	810	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.D822Y(1)		NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCAGGGCCATCTTCCCCTCTT	0.458000													11	38					2.27111e-07	2.45205e-07	1	1	0
AOX1	316	broad.mit.edu	37	2	201503027	201503027	+	Splice_Site	SNP	T	T	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:201503027T>A	ENST00000374700.2	+	23	2809		c.e23+2		AOX1_ENST00000485106.1_Splice_Site	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1						inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	AAGTACAAAGTGAGTACAAGA	0.468000													17	39					0	0	1	0	0
CCR8	1237	broad.mit.edu	37	3	39373966	39373966	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:39373966C>T	ENST00000326306.4	+	2	282	c.144C>T	c.(142-144)ttC>ttT	p.F48F	CCR8_ENST00000545843.1_Intron|CCR8_ENST00000414803.1_Intron	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	48					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		TGTTTGTATTCAGTCTTCTGG	0.483000													41	137					0	0	1	0	0
METAP1	23173	broad.mit.edu	37	4	99960563	99960563	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:99960563C>G	ENST00000296411.6	+	5	513	c.379C>G	c.(379-381)Cag>Gag	p.Q127E	METAP1_ENST00000544031.1_Missense_Mutation_p.Q77E	NM_015143.2	NP_055958.2	P53582	AMPM1_HUMAN	methionyl aminopeptidase 1	127					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis|regulation of translation	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17				OV - Ovarian serous cystadenocarcinoma(123;3.12e-07)		AGGTACTTCTCAGATTAAATT	0.353000													23	65					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34091626	34091626	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:34091626G>C	ENST00000397527.1	+	30	6149	c.5429G>C	c.(5428-5430)aGa>aCa	p.R1810T	CEP250_ENST00000342580.4_Missense_Mutation_p.R1754T	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1810	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding	p.R1810T(1)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GAGGCCCAGAGAGCCCTAGCC	0.597000													9	69					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656696	19656696	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:19656696C>T	ENST00000586018.1	+	8	3462	c.3360C>T	c.(3358-3360)ctC>ctT	p.L1120L	CILP2_ENST00000291495.5_Silent_p.L1114L			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1114						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GACCCAGCCTCTTCCAGAGGC	0.672000													4	19					0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57982343	57982343	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:57982343C>A	ENST00000309433.6	+	1	127	c.127C>A	c.(127-129)Ctt>Att	p.L43I		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				CCTCTTTGTGCTTTTCTTGGG	0.453000													8	193					1.06961e-07	1.15961e-07	1	1	0
ADAMTS19	171019	broad.mit.edu	37	5	128990083	128990083	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:128990083G>C	ENST00000274487.4	+	14	2388	c.2243G>C	c.(2242-2244)tGt>tCt	p.C748S	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	748	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GGAACTTCTTGTGGCTATCAG	0.383000													13	68					0	0	1	0	0
KTN1	3895	broad.mit.edu	37	14	56079010	56079010	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:56079010C>T	ENST00000416613.1	+	1	316	c.244C>T	c.(244-246)Cga>Tga	p.R82*	KTN1_ENST00000395311.1_Nonsense_Mutation_p.R82*|KTN1_ENST00000413890.2_Nonsense_Mutation_p.R82*|KTN1_ENST00000395314.3_Nonsense_Mutation_p.R82*|KTN1_ENST00000395309.3_Nonsense_Mutation_p.R82*|KTN1_ENST00000438792.2_Nonsense_Mutation_p.R82*|KTN1_ENST00000395308.1_Nonsense_Mutation_p.R82*			Q86UP2	KTN1_HUMAN	kinectin 1 (kinesin receptor)	82					microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(4)|central_nervous_system(1)|large_intestine(8)|lung(1)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	19						GAGTGTACCTCGAGACTTTAA	0.363000			T	RET	papillary thryoid								27	50					0	0	1	0	0
B3GNT3	10331	broad.mit.edu	37	19	17919112	17919112	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:17919112G>T	ENST00000318683.6	+	2	643	c.496G>T	c.(496-498)Gag>Tag	p.E166*	B3GNT3_ENST00000595387.1_Nonsense_Mutation_p.E166*	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	166					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						GCTGGAGCTGGAGGCACAGAC	0.642000													11	48					7.03913e-09	7.69507e-09	1	1	0
SMURF2	64750	broad.mit.edu	37	17	62553750	62553750	+	Silent	SNP	G	G	T	rs137921988		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:62553750G>T	ENST00000262435.9	-	13	1594	c.1407C>A	c.(1405-1407)atC>atA	p.I469I		NM_022739.3	NP_073576.1	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	469	HECT.				BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)|skin(4)	22	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			AATCAGGATTGATCTGCAATG	0.323000													26	59					1.2476e-16	1.41912e-16	1	1	0
TTC30A	92104	broad.mit.edu	37	2	178483360	178483360	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:178483360C>A	ENST00000355689.5	-	1	334	c.70G>T	c.(70-72)Gat>Tat	p.D24Y		NM_152275.3	NP_689488.3	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A						cell projection organization	cilium	binding			autonomic_ganglia(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			TAGCGGGCATCGCGGATGAGC	0.672000													7	13					5.18039e-06	5.55496e-06	1	1	0
MAN2B1	4125	broad.mit.edu	37	19	12758381	12758381	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:12758381G>A	ENST00000456935.2	-	22	2736	c.2696C>T	c.(2695-2697)tCg>tTg	p.S899L	MAN2B1_ENST00000221363.4_Missense_Mutation_p.S898L|CTD-2192J16.22_ENST00000597692.1_Silent_p.L85L	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	899					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						CAGGTGCACCGAGGGCGGCAG	0.692000													6	46					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78321350	78321350	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:78321350C>G	ENST00000582970.1	+	29	9358	c.9215C>G	c.(9214-9216)tCt>tGt	p.S3072C	RNF213_ENST00000508628.2_Missense_Mutation_p.S3121C|RNF213_ENST00000336301.6_Missense_Mutation_p.S1145C	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ATTTTTGGTTCTGGTTTCCCC	0.507000													15	80					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78321932	78321932	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:78321932C>T	ENST00000582970.1	+	29	9940	c.9797C>T	c.(9796-9798)gCc>gTc	p.A3266V	RNF213_ENST00000508628.2_Missense_Mutation_p.A3315V|RNF213_ENST00000336301.6_Missense_Mutation_p.A1339V	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ACGCCCGATGCCGTGGTCCGG	0.607000													11	61					0	0	1	0	0
SEC31A	22872	broad.mit.edu	37	4	83772709	83772709	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:83772709G>C	ENST00000432794.1	-	19	2366	c.2203C>G	c.(2203-2205)Caa>Gaa	p.Q735E	SEC31A_ENST00000508479.1_Missense_Mutation_p.Q735E|SEC31A_ENST00000505984.1_Missense_Mutation_p.Q696E|SEC31A_ENST00000348405.4_Missense_Mutation_p.Q696E|SEC31A_ENST00000395310.2_Missense_Mutation_p.Q735E|SEC31A_ENST00000443462.2_Missense_Mutation_p.Q730E|SEC31A_ENST00000326950.5_Missense_Mutation_p.Q696E|SEC31A_ENST00000513858.1_Missense_Mutation_p.Q696E|SEC31A_ENST00000311785.7_Missense_Mutation_p.Q735E|SEC31A_ENST00000500777.2_Missense_Mutation_p.Q696E|SEC31A_ENST00000509142.1_Missense_Mutation_p.Q735E|SEC31A_ENST00000448323.1_Missense_Mutation_p.Q735E|SEC31A_ENST00000264405.5_Missense_Mutation_p.Q468E|SEC31A_ENST00000505472.1_Missense_Mutation_p.Q735E|SEC31A_ENST00000355196.2_Missense_Mutation_p.Q735E|SEC31A_ENST00000508502.1_Missense_Mutation_p.Q735E			O94979	SC31A_HUMAN	SEC31 homolog A (S. cerevisiae)	735					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/ALK(3)|SEC31A/JAK2(4)	breast(1)	1		Hepatocellular(203;0.114)				TCCATGGCTTGAGTGAGTTGC	0.438000													17	38					0	0	1	0	0
ARFGAP1	55738	broad.mit.edu	37	20	61909518	61909518	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:61909518G>C	ENST00000370275.4	+	6	585	c.493G>C	c.(493-495)Gaa>Caa	p.E165Q	ARFGAP1_ENST00000519273.2_Missense_Mutation_p.E52Q|ARFGAP1_ENST00000370283.4_Missense_Mutation_p.E165Q|ARFGAP1_ENST00000519604.1_Missense_Mutation_p.E112Q|ARFGAP1_ENST00000353546.3_Missense_Mutation_p.E165Q|ARFGAP1_ENST00000547204.1_Missense_Mutation_p.E91Q	NM_001281482.1	NP_001268411.1	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating protein 1	165					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)	13	all_cancers(38;1.59e-09)					CAAGGCTTTTGAAGACTGGCT	0.587000													7	130					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31916735	31916735	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:31916735G>A	ENST00000456570.1	+	20	2726	c.2671G>A	c.(2671-2673)Gat>Aat	p.D891N	CFB_ENST00000477310.1_Missense_Mutation_p.D740N|CFB_ENST00000497841.1_3'UTR|CFB_ENST00000556679.1_Missense_Mutation_p.D891N|CFB_ENST00000425368.2_Missense_Mutation_p.D389N			P00751	CFAB_HUMAN	complement factor B	389					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CCTCATGACTGATGGTCAGAA	0.572000													13	54					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151878184	151878184	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:151878184G>A	ENST00000355193.2	-	36	6979	c.6761C>T	c.(6760-6762)gCa>gTa	p.A2254V	KMT2C_ENST00000262189.6_Missense_Mutation_p.A2254V					lysine (K)-specific methyltransferase 2C																		TCGGTTTTGTGCTGCTTGCAG	0.522000													11	75					0	0	1	0	0
OR14I1	401994	broad.mit.edu	37	1	248845225	248845225	+	Silent	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:248845225G>T	ENST00000342623.3	-	1	404	c.381C>A	c.(379-381)ccC>ccA	p.P127P		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						TGTATTGGAGGGGGTGGCAAA	0.522000													21	31					3.51602e-12	3.94798e-12	1	1	0
ITGB4	3691	broad.mit.edu	37	17	73750888	73750888	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:73750888C>A	ENST00000200181.3	+	34	4737	c.4550C>A	c.(4549-4551)tCc>tAc	p.S1517Y	ITGB4_ENST00000579662.1_Missense_Mutation_p.S1447Y|ITGB4_ENST00000450894.3_Missense_Mutation_p.S1447Y|ITGB4_ENST00000449880.2_Missense_Mutation_p.S1447Y|ITGB4_ENST00000339591.3_Missense_Mutation_p.S1447Y|GALK1_ENST00000225614.2_Intron	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1517					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACCTCCGTCTCCTCCCACGGT	0.617000													9	43					0.00621372	0.00631822	1	1	0
GTF3C1	2975	broad.mit.edu	37	16	27549623	27549623	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:27549623C>T	ENST00000356183.4	-	3	501	c.486G>A	c.(484-486)ttG>ttA	p.L162L	GTF3C1_ENST00000561623.1_Silent_p.L162L	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	162						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CCTGGCCTATCAAGGCCCTGT	0.562000													11	77					0	0	1	0	0
KDM5A	5927	broad.mit.edu	37	12	404928	404928	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:404928C>G	ENST00000399788.2	-	26	4628	c.4266G>C	c.(4264-4266)aaG>aaC	p.K1422N	KDM5A_ENST00000382815.4_Missense_Mutation_p.K1422N	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	1422					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						CCAAAGGGCTCTTCCGAGGTT	0.433000			T	NUP98	AML								21	146					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118629576	118629576	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:118629576C>T	ENST00000336338.5	-	11	1480	c.1415G>A	c.(1414-1416)aGa>aAa	p.R472K		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	472						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CCCGTCTGCTCTGGGGGATGG	0.522000													20	133					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78212618	78212618	+	RNA	SNP	A	A	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:78212618A>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TGTAACCGCCACTGGAGGACC	0.562000													4	53					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101715548	101715548	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:101715548C>T	ENST00000342239.3	-	4	1774	c.1683G>A	c.(1681-1683)aaG>aaA	p.K561K	DNMBP-AS1_ENST00000434409.1_RNA|DNMBP_ENST00000324109.4_Silent_p.K561K			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	561					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		CTGCCAAGCTCTTCTCAAACT	0.493000													18	78					0	0	1	0	0
UBE2Q1	55585	broad.mit.edu	37	1	154525255	154525255	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:154525255C>T	ENST00000292211.4	-	6	850	c.771G>A	c.(769-771)atG>atA	p.M257I	UBE2Q1_ENST00000497453.1_5'UTR	NM_017582.6	NP_060052.3	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q family member 1	257							ATP binding|protein binding|ubiquitin-protein ligase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGAGCTCCTTCATCAGCCGGT	0.532000													19	80					0	0	1	0	0
CCDC38	120935	broad.mit.edu	37	12	96312674	96312674	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:96312674C>T	ENST00000344280.3	-	3	675	c.118G>A	c.(118-120)Gaa>Aaa	p.E40K		NM_182496.2	NP_872302.2	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	40										breast(1)|endometrium(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GCTGCCATTTCATTTTCTTTG	0.338000													11	99					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142150446	142150446	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:142150446C>T	ENST00000378004.3	+	1	475	c.120C>T	c.(118-120)atC>atT	p.I40I	ARHGAP26_ENST00000274498.4_Silent_p.I40I	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	40					actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGAGCTCATCAAGGACGGGA	0.602000													4	28					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													6	103					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229713	140229713	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:140229713C>A	ENST00000378122.3	+	1	2357	c.1633C>A	c.(1633-1635)Ctg>Atg	p.L545M	PCDHA9_ENST00000532602.1_Missense_Mutation_p.L545M|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCCGCCTCTGGGCAGCAA	0.682000													27	134					3.73988e-18	4.26021e-18	1	1	0
OTOP3	347741	broad.mit.edu	37	17	72938033	72938033	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:72938033C>T	ENST00000328801.4	+	3	528	c.528C>T	c.(526-528)ctC>ctT	p.L176L		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	176						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CCTTCTGCCTCAACATCTTCC	0.622000													14	26					0	0	1	0	0
PRR14L	253143	broad.mit.edu	37	22	32108385	32108385	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:32108385C>G	ENST00000327423.6	-	4	5629	c.5440G>C	c.(5440-5442)Gac>Cac	p.D1814H	PRR14L_ENST00000397493.2_Missense_Mutation_p.D1814H|PRR14L_ENST00000434485.1_Missense_Mutation_p.D1814H	NM_173566.2	NP_775837.2	Q5THK1	PR14L_HUMAN	proline rich 14-like	1814										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(5)|skin(1)|urinary_tract(2)	14						ACAGAGCAGTCTGCTCTGGTC	0.547000													8	14					0	0	1	0	0
RNGTT	8732	broad.mit.edu	37	6	89616100	89616100	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:89616100C>T	ENST00000369485.4	-	5	613	c.427G>A	c.(427-429)Gag>Aag	p.E143K	RNGTT_ENST00000369475.3_Missense_Mutation_p.E143K|RNGTT_ENST00000265607.6_Missense_Mutation_p.E143K|RNGTT_ENST00000538899.1_Missense_Mutation_p.E83K	NM_003800.3	NP_003791.3	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	143	TPase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	21		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		TCCATTTTCTCCACCAAAAAG	0.299000													3	38					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298745	107298745	+	Nonsense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:107298745G>C	ENST00000374781.2	-	1	392	c.350C>G	c.(349-351)tCa>tGa	p.S117*		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						TCTTTTCTTTGAGATTAAGCT	0.433000													26	65					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51758035	51758035	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:51758035C>G	ENST00000543196.2	-	5	1124	c.919G>C	c.(919-921)Gag>Cag	p.E307Q	GALNT6_ENST00000356317.3_Missense_Mutation_p.E307Q			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	307					protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TTGGCGAACTCAAAAGTATTA	0.577000													8	51					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24908758	24908758	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:24908758G>A	ENST00000396432.2	-	9	2552	c.2066C>T	c.(2065-2067)tCt>tTt	p.S689F	ARHGAP21_ENST00000320481.6_Missense_Mutation_p.S476F	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	688					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						AGGCTTGGCAGAGGCTCCAGA	0.483000													7	86					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66396385	66396385	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:66396385G>A	ENST00000404260.3	+	8	1352	c.1044G>A	c.(1042-1044)agG>agA	p.R348R	MAST4_ENST00000405643.1_Silent_p.R166R|MAST4_ENST00000403666.1_Silent_p.R156R|MAST4_ENST00000261569.7_Silent_p.R151R|MAST4_ENST00000490016.2_Silent_p.R156R|MAST4_ENST00000403625.2_Silent_p.R345R			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	348						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		ACAGATGCAGGAACACGCCGA	0.463000													15	67					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99314828	99314828	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:99314828C>G	ENST00000336374.2	-	6	495	c.493G>C	c.(493-495)Gag>Cag	p.E165Q		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	165					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TTGCCTGTCTCTGCTTCCCGC	0.507000													13	91					0	0	1	0	0
RP4-583P15.15	0	broad.mit.edu	37	20	62366548	62366548	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:62366548C>G	ENST00000490623.2	+	5	746	c.746C>G	c.(745-747)tCc>tGc	p.S249C	ZGPAT_ENST00000355969.6_Missense_Mutation_p.I343M|ZGPAT_ENST00000369967.3_Missense_Mutation_p.I343M|ZGPAT_ENST00000448100.2_Missense_Mutation_p.I343M|ZGPAT_ENST00000357119.4_Missense_Mutation_p.I334M|ZGPAT_ENST00000328969.5_Missense_Mutation_p.I363M																							TGGAGCCCATCCATGCTGTGG	0.667000													3	22					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77862308	77862308	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:77862308G>C	ENST00000407578.2	-	3	848	c.582C>G	c.(580-582)atC>atG	p.I194M	MYCBP2_ENST00000544440.2_Missense_Mutation_p.I156M|MYCBP2_ENST00000357337.6_Missense_Mutation_p.I156M|MYCBP2_ENST00000360084.5_De_novo_Start_InFrame	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTGGAAGCTTGATAGGGGGCT	0.403000													19	125					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127670979	127670979	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:127670979C>G	ENST00000508053.1	-	36	4830	c.3856G>C	c.(3856-3858)Gaa>Caa	p.E1286Q	FBN2_ENST00000262464.4_Missense_Mutation_p.E1286Q|FBN2_ENST00000508989.1_Missense_Mutation_p.E1253Q|FBN2_ENST00000507835.1_Missense_Mutation_p.E136Q			P35556	FBN2_HUMAN	fibrillin 2	1286	EGF-like 20; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTTTCACATTCATCAATGTCT	0.383000													8	60					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43154764	43154764	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:43154764G>C	ENST00000252050.4	+	5	1402	c.1318G>C	c.(1318-1320)Gag>Cag	p.E440Q	CUL9_ENST00000372647.2_Missense_Mutation_p.E440Q|CUL9_ENST00000354495.3_Intron	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	440					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						CCTGGGCCCTGAGGAAGCCAC	0.567000													13	21					0	0	1	0	0
GCDH	2639	broad.mit.edu	37	19	13007149	13007149	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:13007149C>T	ENST00000222214.5	+	8	977	c.766C>T	c.(766-768)Ctg>Ttg	p.L256L	GCDH_ENST00000422947.2_Silent_p.L212L|GCDH_ENST00000457854.1_Silent_p.L256L|GCDH_ENST00000591470.1_Silent_p.L256L			Q92947	GCDH_HUMAN	glutaryl-CoA dehydrogenase	256					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)	19						CAAGTTCTCGCTGCGGGCCTC	0.627000													11	40					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107592559	107592559	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:107592559C>G	ENST00000393561.1	-	21	3445	c.3261G>C	c.(3259-3261)caG>caC	p.Q1087H	LAMB1_ENST00000222399.6_Missense_Mutation_p.Q1063H			P07942	LAMB1_HUMAN	laminin, beta 1	1063	Laminin EGF-like 12.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTCACAGTTCTGCCCGATCA	0.567000													4	23					0	0	1	0	0
NFKB2	4791	broad.mit.edu	37	10	104160055	104160055	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:104160055G>C	ENST00000369966.3	+	16	1855	c.1605G>C	c.(1603-1605)gtG>gtC	p.V535V	NFKB2_ENST00000428099.1_Silent_p.V535V|NFKB2_ENST00000189444.6_Silent_p.V535V	NM_001077494.2	NP_001070962.1	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	535					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|skin(2)	23		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		ACCTGGCGGTGATCACGGGGC	0.662000			T	IGH@	B-NHL								14	56					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49132480	49132480	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:49132480C>T	ENST00000443164.1	+	5	2306	c.1601C>T	c.(1600-1602)tCt>tTt	p.S534F	SPHK2_ENST00000598088.1_Missense_Mutation_p.S472F|SPHK2_ENST00000600537.1_Missense_Mutation_p.S413F|SPHK2_ENST00000340932.3_Missense_Mutation_p.S434F|SPHK2_ENST00000599748.1_Missense_Mutation_p.S436F|SPHK2_ENST00000599029.1_Missense_Mutation_p.S436F|SPHK2_ENST00000245222.4_Missense_Mutation_p.S472F			Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	472					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CCACTGCTGTCTTCACCTCCT	0.672000													15	100					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133796958	133796958	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:133796958C>A	ENST00000321016.8	-	13	1890	c.1660G>T	c.(1660-1662)Gac>Tac	p.D554Y	IGSF9B_ENST00000533871.2_Missense_Mutation_p.D554Y			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	554	Fibronectin type-III 1.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GACAGCCAGTCATGGGGCCCA	0.627000													5	3					0.014758	0.0149289	1	1	0
CPT1A	1374	broad.mit.edu	37	11	68582809	68582809	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:68582809C>T	ENST00000265641.5	-	2	288	c.134G>A	c.(133-135)aGa>aAa	p.R45K	CPT1A_ENST00000376618.2_Missense_Mutation_p.R45K|CPT1A_ENST00000540367.1_Missense_Mutation_p.R45K|CPT1A_ENST00000539743.1_Missense_Mutation_p.R45K	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	45					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	AACCTTGAATCTGATGAACTT	0.443000													30	60					0	0	1	0	0
FAM161A	84140	broad.mit.edu	37	2	62063219	62063219	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:62063219C>G	ENST00000404929.1	-	5	1788	c.1777G>C	c.(1777-1779)Gaa>Caa	p.E593Q	FAM161A_ENST00000405894.3_Missense_Mutation_p.E537Q	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	540					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CGTTGGTATTCTCTCATCCTT	0.303000													66	81					0	0	1	0	0
ANGPTL1	9068	broad.mit.edu	37	1	178821845	178821845	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:178821845G>T	ENST00000234816.2	-	5	1708	c.1261C>A	c.(1261-1263)Ctg>Atg	p.L421M	RALGPS2_ENST00000367635.3_Intron|ANGPTL1_ENST00000367629.1_Missense_Mutation_p.L421M|RALGPS2_ENST00000367634.2_Intron	NM_004673.3	NP_004664.1	O95841	ANGL1_HUMAN	angiopoietin-like 1	421	Fibrinogen C-terminal.					extracellular space	receptor binding			breast(2)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	14						TCTCTGTCCAGTGTGGTGAAT	0.363000													7	119					8.12818e-05	8.55255e-05	1	1	0
DPYD	1806	broad.mit.edu	37	1	97771776	97771776	+	Silent	SNP	T	T	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:97771776T>G	ENST00000370192.3	-	17	2236	c.2136A>C	c.(2134-2136)ccA>ccC	p.P712P	DPYD-AS1_ENST00000422980.1_RNA	NM_000110.3	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	712					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CAGTGACATTTGGGGTCAGCT	0.453000													47	212					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516029	140516029	+	Missense_Mutation	SNP	A	A	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:140516029A>T	ENST00000231134.5	+	1	1230	c.1013A>T	c.(1012-1014)gAt>gTt	p.D338V		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		338	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAGTGGTGGATGTGAATGAC	0.488000													19	111					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114184734	114184734	+	Missense_Mutation	SNP	A	A	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:114184734A>T	ENST00000369615.1	+	10	1624	c.1562A>T	c.(1561-1563)aAg>aTg	p.K521M	MAGI3_ENST00000369611.4_Missense_Mutation_p.K521M|MAGI3_ENST00000369617.4_Missense_Mutation_p.K546M|MAGI3_ENST00000307546.9_Missense_Mutation_p.K521M	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	546					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCATTAACCAAGGGAGAGACT	0.458000													12	85					0	0	1	0	0
PTPN9	5780	broad.mit.edu	37	15	75798183	75798183	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:75798183G>C	ENST00000306726.2	-	7	1313	c.801C>G	c.(799-801)ttC>ttG	p.F267L		NM_002833.2	NP_002824.1	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type 9	267						cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GAGGGAGGGAGAACAGGATGA	0.522000													9	60					0	0	1	0	0
GLI3	2737	broad.mit.edu	37	7	42088199	42088199	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:42088199G>A	ENST00000395925.3	-	5	654	c.570C>T	c.(568-570)ttC>ttT	p.F190F	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	190					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						GTGGAGGGCTGAAGGGAGACT	0.572000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				10	98					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64669802	64669802	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:64669802G>A	ENST00000421419.2	-	28	3954	c.3840C>T	c.(3838-3840)atC>atT	p.I1280I	ATG2A_ENST00000377264.3_Silent_p.I1278I			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1278							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						CACGCTGGTTGATGAGGGCCG	0.672000													4	25					0	0	1	0	0
CD9	928	broad.mit.edu	37	12	6344708	6344708	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:6344708G>T	ENST00000382518.1	+	7	950	c.514G>T	c.(514-516)Gta>Tta	p.V172L	CD9_ENST00000009180.4_Missense_Mutation_p.V172L|CD9_ENST00000382515.2_Missense_Mutation_p.V103L|CD9_ENST00000481267.1_3'UTR			P21926	CD9_HUMAN	CD9 molecule	172					cell adhesion|cellular component movement|fusion of sperm to egg plasma membrane|paranodal junction assembly|platelet activation|platelet degranulation	integral to plasma membrane|platelet alpha granule membrane				endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|stomach(1)	8						CAAGAAGGACGTACTCGAAAC	0.537000													6	60					6.5536e-12	7.34826e-12	1	1	0
TBC1D1	23216	broad.mit.edu	37	4	38126707	38126707	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:38126707G>A	ENST00000261439.4	+	18	3442	c.3087G>A	c.(3085-3087)acG>acA	p.T1029T	TBC1D1_ENST00000407365.1_3'UTR|TBC1D1_ENST00000508802.1_Intron	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	1029						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						TAAAAAGCACGCTACCCAACC	0.408000													13	60					0	0	1	0	0
PRRT3	285368	broad.mit.edu	37	3	9989042	9989042	+	Silent	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:9989042C>A	ENST00000412055.1	-	4	1944	c.1815G>T	c.(1813-1815)tcG>tcT	p.S605S		NM_207351.3	NP_997234.3	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3	605						integral to membrane				NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)|stomach(2)	13						CCCAGGCGCACGACAAGCCCT	0.711000													5	15					0.014758	0.0149289	1	1	0
TTN	7273	broad.mit.edu	37	2	179498312	179498312	+	Silent	SNP	T	T	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:179498312T>C	ENST00000589042.1	-	232	42998	c.42774A>G	c.(42772-42774)gtA>gtG	p.V14258V	TTN_ENST00000342992.6_Silent_p.V11690V|TTN_ENST00000460472.2_Silent_p.V5193V|TTN_ENST00000342175.6_Silent_p.V5385V|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.V12617V|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000359218.5_Silent_p.V5318V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12617	Fibronectin type-III 3.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTCACTGGTACATCTTTGC	0.428000													7	36					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65178355	65178355	+	Missense_Mutation	SNP	T	T	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr18:65178355T>G	ENST00000310045.7	-	2	4994	c.3521A>C	c.(3520-3522)aAc>aCc	p.N1174T	CTD-2541J13.2_ENST00000583493.1_RNA|CTD-2541J13.2_ENST00000581951.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1164						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				GTAAAAAAGGTTTGTAGAGGT	0.348000													9	43					0	0	1	0	0
CNTNAP3B	728577	broad.mit.edu	37	9	43822654	43822654	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:43822654G>C	ENST00000377564.3	+	8	1601	c.1208G>C	c.(1207-1209)aGa>aCa	p.R403T		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	403	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						ACGTGGAACAGAGCAGGACAT	0.502000													6	32					0	0	1	0	0
FOCAD	54914	broad.mit.edu	37	9	20990271	20990271	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:20990271G>A	ENST00000380249.1	+	44	5518	c.5154G>A	c.(5152-5154)agG>agA	p.R1718R	FOCAD_ENST00000605086.1_Silent_p.R1154R|FOCAD_ENST00000338382.6_Silent_p.R1718R	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	1718						integral to membrane	binding										TCCTTGGCAGGAGTCCAATGC	0.587000													33	24					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30336501	30336501	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:30336501C>T	ENST00000375377.1	-	2	342	c.241G>A	c.(241-243)Gag>Aag	p.E81K		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	81										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						CTCTGGGGCTCCCCGTGGCCT	0.607000													7	64					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101608973	101608973	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:101608973G>C	ENST00000311812.2	-	10	1022	c.872C>G	c.(871-873)tCt>tGt	p.S291C	SNX31_ENST00000428383.2_Missense_Mutation_p.S192C	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	291					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			ATTGCCAACAGAAAGAACAGC	0.542000													53	94					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5037247	5037247	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:5037247G>A	ENST00000574788.1	+	15	2680	c.450G>A	c.(448-450)acG>acA	p.T150T	USP6_ENST00000304328.5_5'UTR|USP6_ENST00000332776.4_Silent_p.T150T|USP6_ENST00000250066.6_Silent_p.T150T			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	150	Rab-GAP TBC.				protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						ACGTGAGGACGACTCTCCGGA	0.562000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								30	92					0	0	1	0	0
PIP4K2A	5305	broad.mit.edu	37	10	22896931	22896931	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:22896931G>C	ENST00000376573.4	-	3	492	c.264C>G	c.(262-264)ttC>ttG	p.F88L	PIP4K2A_ENST00000422321.1_5'UTR|PIP4K2A_ENST00000545335.1_Missense_Mutation_p.F29L	NM_005028.4	NP_005019.2	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	88	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			endometrium(4)|kidney(13)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	29						CCTTAAACTTGAAATGGCTCG	0.458000													5	33					0	0	1	0	0
MATN3	4148	broad.mit.edu	37	2	20205566	20205566	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:20205566G>T	ENST00000407540.3	-	2	791	c.729C>A	c.(727-729)ttC>ttA	p.F243L	MATN3_ENST00000421259.2_Missense_Mutation_p.F243L	NM_002381.4	NP_002372.1	O15232	MATN3_HUMAN	matrilin 3	243	VWFA.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTCCACGTAGAAAACATGCT	0.507000													7	4					1.6384e-10	1.81123e-10	1	1	0
ZFR	51663	broad.mit.edu	37	5	32390503	32390503	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:32390503C>T	ENST00000265069.8	-	12	2122	c.2020G>A	c.(2020-2022)Gaa>Aaa	p.E674K		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	674					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding	p.E674Q(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		TGATGTTGTTCTTCCTCCATT	0.478000													13	72					0	0	1	0	0
FCGRT	2217	broad.mit.edu	37	19	50027840	50027840	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:50027840C>G	ENST00000221466.5	+	5	1164	c.678C>G	c.(676-678)ttC>ttG	p.F226L	FCGRT_ENST00000596975.1_Missense_Mutation_p.F134L|FCGRT_ENST00000426395.3_Missense_Mutation_p.F226L|FCGRT_ENST00000599988.1_Intron|FCGRT_ENST00000594823.1_3'UTR	NM_001136019.2	NP_001129491.1	P55899	FCGRN_HUMAN	Fc fragment of IgG, receptor, transporter, alpha	226	Alpha-3.				antigen processing and presentation|female pregnancy|immune response	integral to membrane|MHC class I protein complex	IgG binding|receptor activity			endometrium(3)|kidney(2)|lung(1)|ovary(1)|prostate(1)|skin(1)	9		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00291)|GBM - Glioblastoma multiforme(134;0.0156)		CCTTCTCCTTCTACCCTCCGG	0.652000													9	64					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19765986	19765986	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:19765986C>G	ENST00000357324.6	-	12	1623	c.1597G>C	c.(1597-1599)Gac>Cac	p.D533H	ATP13A1_ENST00000496082.1_5'UTR|ATP13A1_ENST00000291503.5_Missense_Mutation_p.D415H	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	533					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CCCGTCTTGTCAAAGCAGCAC	0.637000													4	30					0	0	1	0	0
GRTP1	79774	broad.mit.edu	37	13	114009708	114009708	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:114009708C>G	ENST00000375430.4	-	3	316	c.270G>C	c.(268-270)caG>caC	p.Q90H	GRTP1-AS1_ENST00000419199.1_RNA|GRTP1_ENST00000326039.3_Missense_Mutation_p.Q12H|GRTP1-AS1_ENST00000423246.1_RNA|GRTP1_ENST00000375431.4_Missense_Mutation_p.Q90H			Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	90	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			AGCCGGGATTCTGGTCCATCT	0.652000													16	35					0	0	1	0	0
MRPS17	51373	broad.mit.edu	37	7	56022744	56022744	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:56022744G>A	ENST00000285298.4	+	3	395	c.266G>A	c.(265-267)gGa>gAa	p.G89E	MRPS17_ENST00000426595.1_Missense_Mutation_p.G184E	NM_015969.2	NP_057053.1	Q9Y2R5	RT17_HUMAN	mitochondrial ribosomal protein S17	89					translation	mitochondrial small ribosomal subunit	rRNA binding|structural constituent of ribosome			kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTCAAAGTTGGAAAAGTCATA	0.473000													19	112					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98649868	98649868	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:98649868G>C	ENST00000261574.5	+	12	1231	c.1051G>C	c.(1051-1053)Gac>Cac	p.D351H	IPO5_ENST00000490680.1_Missense_Mutation_p.D333H|IPO5_ENST00000539640.1_Missense_Mutation_p.D208H	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	333	Ran-GTP binding (By similarity).				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						TGATGATTTTGACAGGTAATC	0.418000													6	28					0	0	1	0	0
C20orf166	128826	broad.mit.edu	37	20	61167667	61167667	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:61167667C>G	ENST00000370527.3	+	4	916	c.137C>G	c.(136-138)tCc>tGc	p.S46C	C20orf166_ENST00000370524.2_Missense_Mutation_p.S28C|C20orf166_ENST00000370523.1_Missense_Mutation_p.S28C	NM_178463.3	NP_848558.1	Q9H1L0	CT166_HUMAN	chromosome 20 open reading frame 166	46										endometrium(1)|kidney(1)|lung(2)	4	Breast(26;1.04e-08)		BRCA - Breast invasive adenocarcinoma(19;7.17e-06)			CCTGAAATGTCCATTACTCAC	0.502000													21	21					0	0	1	0	0
HPS6	79803	broad.mit.edu	37	10	103826020	103826020	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:103826020C>T	ENST00000299238.5	+	1	874	c.789C>T	c.(787-789)tcC>tcT	p.S263S		NM_024747.5	NP_079023.2	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome 6	263						cytosol|early endosome membrane|endoplasmic reticulum|microsome				endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)	11		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		GGTTGCTGTCCCCCAGGGAGC	0.632000									Hermansky-Pudlak syndrome				8	56					0	0	1	0	0
CCT3	7203	broad.mit.edu	37	1	156305640	156305640	+	Translation_Start_Site	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:156305640G>C	ENST00000368261.3	-	0	295				CCT3_ENST00000472765.2_De_novo_Start_OutOfFrame|CCT3_ENST00000368256.3_5'UTR|CCT3_ENST00000368259.2_Missense_Mutation_p.S24C|CCT3_ENST00000295688.3_Missense_Mutation_p.S24C			P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)						'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					GATGTTTCCAGATTGAACTTT	0.428000													27	72					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14759863	14759863	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:14759863C>T	ENST00000380881.4	-	29	6059	c.5244G>A	c.(5242-5244)caG>caA	p.Q1748Q	FREM1_ENST00000486223.1_5'UTR|FREM1_ENST00000422223.2_Silent_p.Q1747Q|FREM1_ENST00000380894.1_Silent_p.Q283Q|FREM1_ENST00000380880.3_Silent_p.Q1747Q			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1747	Calx-beta.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CATATTCGGTCTGTGACCATT	0.413000													44	75					0	0	1	0	0
CYP1A1	1543	broad.mit.edu	37	15	75013974	75013974	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:75013974C>G	ENST00000379727.3	-	3	1108	c.910G>C	c.(910-912)Gat>Cat	p.D304H	CYP1A1_ENST00000564596.1_Missense_Mutation_p.D43H|CYP1A1_ENST00000567032.1_Missense_Mutation_p.D304H|CYP1A1_ENST00000395049.4_Missense_Mutation_p.D304H|CYP1A1_ENST00000395048.2_Missense_Mutation_p.D304H			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	304					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	ATCTTCTCATCTGACAGCTGG	0.527000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				9	55					0	0	1	0	0
FAM118A	55007	broad.mit.edu	37	22	45726591	45726591	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:45726591C>T	ENST00000216214.3	+	6	1464	c.630C>T	c.(628-630)gtC>gtT	p.V210V	FAM118A_ENST00000441876.2_Silent_p.V210V|FAM118A_ENST00000405548.3_Silent_p.V28V	NM_001104595.1	NP_001098065.1	Q9NWS6	F118A_HUMAN	family with sequence similarity 118, member A	210						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	11		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		ATAAAGACGTCACTCAAGACG	0.582000													11	34					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922498	24922498	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:24922498C>A	ENST00000329468.2	+	1	1958	c.1484C>A	c.(1483-1485)tCt>tAt	p.S495Y		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCTCTCACTTCTGACCCCCCA	0.532000													97	253					1.53058e-52	1.7486e-52	1	1	0
USP26	83844	broad.mit.edu	37	X	132161288	132161288	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:132161288C>T	ENST00000511190.1	-	6	1430	c.961G>A	c.(961-963)Gat>Aat	p.D321N	USP26_ENST00000406273.1_Missense_Mutation_p.D321N|USP26_ENST00000370832.1_Missense_Mutation_p.D321N	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	321					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					AGTAAATCATCAGCAAACGAT	0.383000													24	23					0	0	1	0	0
STPG2	285555	broad.mit.edu	37	4	99055545	99055545	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:99055545C>G	ENST00000295268.3	-	2	264	c.175G>C	c.(175-177)Gag>Cag	p.E59Q		NM_174952.2	NP_777612.1			sperm-tail PG-rich repeat containing 2																		ACAGCTTTCTCAATGCTAGAG	0.348000													25	71					0	0	1	0	0
NEMF	9147	broad.mit.edu	37	14	50269421	50269421	+	Nonsense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:50269421G>C	ENST00000298310.5	-	21	2389	c.1940C>G	c.(1939-1941)tCa>tGa	p.S647*	NEMF_ENST00000545773.1_Nonsense_Mutation_p.S605*|NEMF_ENST00000556925.1_5'UTR|NEMF_ENST00000546046.1_Nonsense_Mutation_p.S626*			O60524	NEMF_HUMAN	nuclear export mediator factor	647						cytoplasm|nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(13)|liver(1)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	36						CATTAGATATGAGGGAGGAAG	0.294000													11	49					0	0	1	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118006429	118006429	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:118006429C>G	ENST00000310754.4	-	1	307	c.121G>C	c.(121-123)Gag>Cag	p.E41Q		NM_152402.2	NP_689615.2	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like 1	41					protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22						GCTGTTCCCTCGAACACAAGC	0.547000													11	49					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100152236	100152236	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:100152236G>C	ENST00000263174.4	+	4	631	c.256G>C	c.(256-258)Gag>Cag	p.E86Q	PALMD_ENST00000605497.1_Missense_Mutation_p.E86Q	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	86					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		TGTCAGGCTTGAGAAAGAGAT	0.358000													11	57					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52569145	52569145	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:52569145G>A	ENST00000389534.4	-	7	2449	c.1990C>T	c.(1990-1992)Cag>Tag	p.Q664*	ZNF432_ENST00000598446.1_Intron|ZNF841_ENST00000426391.2_Nonsense_Mutation_p.Q548*|ZNF841_ENST00000594295.1_Nonsense_Mutation_p.Q664*|ZNF841_ENST00000359973.2_Intron	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	548					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						CTTGAACGCTGAGTATAGGCT	0.413000													10	72					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7782073	7782073	+	Missense_Mutation	SNP	T	T	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:7782073T>G	ENST00000357716.4	+	10	3002	c.2728T>G	c.(2728-2730)Tat>Gat	p.Y910D	GRM7_ENST00000486284.1_3'UTR	NM_000844.3	NP_000835.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	910					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GTATGTCAGTTATAATAACCT	0.403000													10	50					0	0	1	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32928554	32928554	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:32928554C>T	ENST00000361627.3	+	12	2302	c.1580C>T	c.(1579-1581)tCa>tTa	p.S527L	ARHGAP11A_ENST00000565905.1_Missense_Mutation_p.S338L|ARHGAP11A_ENST00000543522.1_Missense_Mutation_p.S338L	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	527					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		CCTAATAATTCAAGTTTTCAA	0.383000													12	46					0	0	1	0	0
ZHX3	23051	broad.mit.edu	37	20	39831489	39831489	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:39831489C>T	ENST00000309060.3	-	4	2483	c.2068G>A	c.(2068-2070)Gag>Aag	p.E690K	ZHX3_ENST00000540170.1_Missense_Mutation_p.E690K|ZHX3_ENST00000544979.2_Missense_Mutation_p.E690K|ZHX3_ENST00000559234.1_Missense_Mutation_p.E690K|ZHX3_ENST00000557816.1_Intron|ZHX3_ENST00000560361.1_Missense_Mutation_p.E690K|ZHX3_ENST00000432768.2_Missense_Mutation_p.E690K|ZHX3_ENST00000558993.1_Intron			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	690					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				TCTCCACCCTCATCCTCAGCA	0.517000													9	169					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36149306	36149306	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:36149306G>A	ENST00000303965.4	-	18	3552	c.3063C>T	c.(3061-3063)ctC>ctT	p.L1021L		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1021	PH 4.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						CTTTGTAGAAGAGTTGACCAA	0.378000													11	52					0	0	1	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819021	50819021	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:50819021G>A	ENST00000374115.3	+	1	675	c.235G>A	c.(235-237)Gag>Aag	p.E79K	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	79					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						CGAGGTGTGGGAGCCCACCCT	0.701000													8	16					0	0	1	0	0
FAM105A	54491	broad.mit.edu	37	5	14602366	14602366	+	Silent	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:14602366C>G	ENST00000274217.3	+	5	543	c.423C>G	c.(421-423)ctC>ctG	p.L141L		NM_019018.2	NP_061891.1	Q9NUU6	F105A_HUMAN	family with sequence similarity 105, member A	141										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					ATGATGCTCTCAGATCAGTGT	0.383000													11	50					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77690569	77690569	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:77690569G>C	ENST00000521891.2	+	4	3667	c.3219G>C	c.(3217-3219)caG>caC	p.Q1073H	ZFHX4_ENST00000455469.2_Missense_Mutation_p.Q1047H|ZFHX4_ENST00000518282.1_Missense_Mutation_p.Q1047H|ZFHX4_ENST00000517683.1_3'UTR|ZFHX4_ENST00000050961.6_Missense_Mutation_p.Q1047H	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1047						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGCATCAGCAGACTGAGGGCC	0.502000										HNSCC(33;0.089)			21	151					0	0	1	0	0
ZC3H7A	29066	broad.mit.edu	37	16	11850152	11850152	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:11850152G>A	ENST00000396516.2	-	20	2700	c.2503C>T	c.(2503-2505)Cag>Tag	p.Q835*	ZC3H7A_ENST00000355758.4_Nonsense_Mutation_p.Q835*|ZC3H7A_ENST00000575984.1_Nonsense_Mutation_p.Q31*			Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	835						nucleus	nucleic acid binding|zinc ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(2)	25						TTGTTTGACTGACTGGCTATG	0.373000													11	65					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12921480	12921480	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:12921480G>A	ENST00000240189.2	+	4	1358	c.1271G>A	c.(1270-1272)cGt>cAt	p.R424H		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	424										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTTGGTTCGTGTCAATTGG	0.562000													25	128					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85525405	85525405	+	Missense_Mutation	SNP	A	A	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:85525405A>G	ENST00000295887.5	+	2	550	c.127A>G	c.(127-129)Att>Gtt	p.I43V		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	43					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		GGAAACAGATATTGATGACAG	0.353000													12	54					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12943166	12943166	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:12943166C>T	ENST00000235349.5	-	2	120	c.50G>A	c.(49-51)cGg>cAg	p.R17Q		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	17								p.R17Q(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TAGCAGGCTCCGCCCTGCAAG	0.562000													32	171					0	0	1	0	0
POM121C	100101267	broad.mit.edu	37	7	75070254	75070254	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:75070254C>G	ENST00000453279.2	-	5	1069	c.205G>C	c.(205-207)Gat>Cat	p.D69H	POM121C_ENST00000257665.5_Missense_Mutation_p.D311H	NM_001099415.1	NP_001092885	A8CG34	P121C_HUMAN	POM121 transmembrane nucleoporin C	311	Pore side (Potential).|Required for targeting to the nucleus and nuclear pore complex.				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14						TCCTGGCCATCAAGGAATATT	0.463000													29	259					0	0	1	0	0
GNMT	27232	broad.mit.edu	37	6	42930880	42930880	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:42930880C>T	ENST00000372808.3	+	4	532	c.522C>T	c.(520-522)gtC>gtT	p.V174V		NM_018960.4	NP_061833.1	Q14749	GNMT_HUMAN	glycine N-methyltransferase	174					protein homotetramerization|protein modification process|S-adenosylmethionine metabolic process		folic acid binding|glycine binding|glycine N-methyltransferase activity			kidney(2)|large_intestine(1)|lung(1)	4	Colorectal(47;0.196)		all cancers(41;0.00196)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0461)		Glycine(DB00145)|S-Adenosylmethionine(DB00118)	GCCTACTGGTCATTGATCATC	0.612000													7	31					0	0	1	0	0
CCL13	6357	broad.mit.edu	37	17	32685048	32685048	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:32685048C>G	ENST00000225844.2	+	3	270	c.195C>G	c.(193-195)ttC>ttG	p.F65L		NM_005408.2	NP_005399.1	Q99616	CCL13_HUMAN	chemokine (C-C motif) ligand 13	65					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response	extracellular space	chemokine activity|signal transducer activity			large_intestine(1)|prostate(1)	2		Ovarian(249;0.0443)|Breast(31;0.151)				TCCACAGCTTCAGAACCAAAC	0.512000													5	40					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64519341	64519341	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:64519341G>T	ENST00000358025.3	+	48	8940	c.8710G>T	c.(8710-8712)Gag>Tag	p.E2904*	SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Nonsense_Mutation_p.E2904*|SYNE2_ENST00000554584.1_Nonsense_Mutation_p.E2937*	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2904					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CATCTATGAGGAGCTGAATGT	0.348000													7	25					0.00198382	0.00203296	1	1	0
VPS45	11311	broad.mit.edu	37	1	150053426	150053426	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:150053426G>A	ENST00000369130.3	+	8	1236	c.690G>A	c.(688-690)tgG>tgA	p.W230*	VPS45_ENST00000535106.1_Nonsense_Mutation_p.W161*|VPS45_ENST00000369128.5_Nonsense_Mutation_p.W125*	NM_001279354.1|NM_007259.3	NP_001266283.1|NP_009190.2	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45 homolog (S. cerevisiae)	230					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTATTTAGTGGACATATCAGG	0.353000													6	64					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71374687	71374687	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:71374687C>T	ENST00000304743.2	+	1	566	c.120C>T	c.(118-120)ctC>ctT	p.L40L	PCNX_ENST00000238570.5_Silent_p.L40L|PCNX_ENST00000439984.3_Silent_p.L40L	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	40						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		ACCTGTGGCTCTTTCTGCTGG	0.692000													7	7					0	0	1	0	0
URGCP	55665	broad.mit.edu	37	7	43916762	43916762	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:43916762C>A	ENST00000336086.6	-	4	4407	c.2171G>T	c.(2170-2172)aGa>aTa	p.R724I	URGCP_ENST00000223341.7_Missense_Mutation_p.R724I|URGCP-MRPS24_ENST00000603700.1_Intron|URGCP_ENST00000447717.3_Missense_Mutation_p.R724I|URGCP_ENST00000453200.1_Missense_Mutation_p.R767I|URGCP_ENST00000497914.1_5'UTR|URGCP_ENST00000443736.1_Missense_Mutation_p.R724I|URGCP_ENST00000402306.3_Missense_Mutation_p.R758I			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	767					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CAGCTCAAATCTGTCCCCAGC	0.567000													10	63					0.000442599	0.000460772	1	1	0
TRAPPC11	60684	broad.mit.edu	37	4	184612493	184612493	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:184612493G>A	ENST00000334690.6	+	19	2120	c.1918G>A	c.(1918-1920)Gaa>Aaa	p.E640K	TRAPPC11_ENST00000512476.1_Missense_Mutation_p.E246K|TRAPPC11_ENST00000357207.4_Missense_Mutation_p.E640K	NM_021942.5	NP_068761.4	Q7Z392	CD041_HUMAN	trafficking protein particle complex 11	640																	CTGTGTAATAGAAGAAGCATC	0.383000													6	62					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121220591	121220591	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:121220591G>A	ENST00000297848.3	+	11	1582	c.1312G>A	c.(1312-1314)Gaa>Aaa	p.E438K	COL14A1_ENST00000537875.1_Missense_Mutation_p.E438K|COL14A1_ENST00000309791.4_Missense_Mutation_p.E438K|COL14A1_ENST00000247781.3_Missense_Mutation_p.E343K|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	438	Fibronectin type-III 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACGGGGAACTGAAACTACACG	0.398000													17	59					0	0	1	0	0
VTCN1	79679	broad.mit.edu	37	1	117699367	117699367	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:117699367C>G	ENST00000369458.3	-	3	352	c.274G>C	c.(274-276)Gag>Cag	p.E92Q	VTCN1_ENST00000463461.1_5'UTR|VTCN1_ENST00000539893.1_5'UTR|VTCN1_ENST00000328189.3_Intron|VTCN1_ENST00000359008.4_Missense_Mutation_p.E95Q	NM_024626.3	NP_078902.2	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation inhibitor 1	92	Ig-like V-type 1.					integral to membrane|plasma membrane				large_intestine(7)|lung(4)|upper_aerodigestive_tract(1)	12	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		TCATCCTGCTCCGACAGCTCA	0.463000													11	100					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78400700	78400700	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:78400700C>G	ENST00000397909.2	+	8	1555	c.1382C>G	c.(1381-1383)tCt>tGt	p.S461C	NAV3_ENST00000536525.2_Missense_Mutation_p.S461C|NAV3_ENST00000266692.7_Missense_Mutation_p.S461C|NAV3_ENST00000228327.6_Missense_Mutation_p.S461C			Q8IVL0	NAV3_HUMAN	neuron navigator 3	461						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity	p.S461F(1)		NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AATAAAAAGTCTTTGCTACAG	0.413000										HNSCC(70;0.22)			18	85					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37627686	37627686	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:37627686C>T	ENST00000447079.4	+	2	1634	c.1601C>T	c.(1600-1602)tCt>tTt	p.S534F	CDK12_ENST00000430627.2_Missense_Mutation_p.S534F	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	534					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						ACAATTGCTTCTCCCCCACCC	0.522000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			16	91					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151853410	151853410	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:151853410G>C	ENST00000355193.2	-	46	12081	c.11863C>G	c.(11863-11865)Cca>Gca	p.P3955A	KMT2C_ENST00000262189.6_Missense_Mutation_p.P3898A					lysine (K)-specific methyltransferase 2C																		GGGGGTGTTGGAGGATTACTT	0.428000													15	74					0	0	1	0	0
TOX4	9878	broad.mit.edu	37	14	21945698	21945698	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:21945698C>T	ENST00000405508.1	+	3	326	c.50C>T	c.(49-51)tCg>tTg	p.S17L	TOX4_ENST00000262709.3_Missense_Mutation_p.S17L|TOX4_ENST00000448790.2_Intron|TOX4_ENST00000494242.1_3'UTR			O94842	TOX4_HUMAN	TOX high mobility group box family member 4	17						chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			large_intestine(8)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		ACAGGGCCTTCGCACCCCTTC	0.622000											OREG0022569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	76					0	0	1	0	0
EZH1	2145	broad.mit.edu	37	17	40874832	40874832	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:40874832C>T	ENST00000428826.2	-	6	589	c.468G>A	c.(466-468)ggG>ggA	p.G156G	EZH1_ENST00000590078.1_Silent_p.G86G|EZH1_ENST00000435174.1_Intron|EZH1_ENST00000585893.1_Silent_p.G116G|EZH1_ENST00000415827.2_Silent_p.G147G|EZH1_ENST00000592743.1_Silent_p.G156G			Q92800	EZH1_HUMAN	enhancer of zeste homolog 1 (Drosophila)	156					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			breast(1)|endometrium(4)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	27		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		CATGGACTTTCCCATCATAGT	0.403000													10	102					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101918591	101918591	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:101918591G>C	ENST00000437600.4	+	17	1870	c.1518G>C	c.(1516-1518)caG>caC	p.Q506H	CUX1_ENST00000425244.2_Missense_Mutation_p.Q462H|CUX1_ENST00000292538.4_Missense_Mutation_p.Q508H|CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000393824.3_Missense_Mutation_p.Q469H|CUX1_ENST00000547394.2_Missense_Mutation_p.Q492H	NM_181500.2	NP_852477.1	P39880	CUX1_HUMAN	cut-like homeobox 1	320					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TCTCCAGCCAGAGGGAGCGCT	0.622000													7	53					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126242013	126242013	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:126242013G>T	ENST00000394329.3	+	1	4460	c.4447G>T	c.(4447-4449)Gaa>Taa	p.E1483*		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1483	Cadherin 14.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TACTAATGCTGAAATAGATCG	0.383000													21	110					7.45023e-12	8.3417e-12	1	1	0
LPCAT3	10162	broad.mit.edu	37	12	7090195	7090195	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:7090195C>T	ENST00000261407.4	-	6	733	c.648G>A	c.(646-648)ctG>ctA	p.L216L	LPCAT3_ENST00000535021.1_5'UTR	NM_005768.5	NP_005759.4	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	216					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	17						GTATGTCAATCAGCTCTCCCT	0.478000													38	142					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19475284	19475284	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:19475284C>G	ENST00000396229.2	+	8	2172	c.1423C>G	c.(1423-1425)Cag>Gag	p.Q475E	TMC5_ENST00000541464.1_Missense_Mutation_p.Q475E|TMC5_ENST00000219821.5_Missense_Mutation_p.Q229E|TMC5_ENST00000381414.4_Missense_Mutation_p.Q475E|TMC5_ENST00000561503.1_Missense_Mutation_p.Q116E|TMC5_ENST00000564959.1_Missense_Mutation_p.Q158E|TMC5_ENST00000542583.2_Missense_Mutation_p.Q475E	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	475						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CATAATCCCTCAGTTTACCGT	0.468000													16	72					0	0	1	0	0
MAP3K14	9020	broad.mit.edu	37	17	43363800	43363800	+	RNA	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:43363800C>T	ENST00000344686.2	-	0	1255							Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TTAGTTACCTCAGTGAGCAGG	0.572000													4	9					0	0	1	0	0
ABI2	10152	broad.mit.edu	37	2	204281636	204281636	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:204281636G>C	ENST00000295851.5	+	10	1494	c.1198G>C	c.(1198-1200)Gat>Cat	p.D400H	ABI2_ENST00000261016.6_Missense_Mutation_p.D288H|ABI2_ENST00000261017.5_Missense_Mutation_p.D362H|RAPH1_ENST00000457812.1_Intron|ABI2_ENST00000424558.1_Missense_Mutation_p.D394H|ABI2_ENST00000430574.1_3'UTR|ABI2_ENST00000430418.1_Missense_Mutation_p.D345H|ABI2_ENST00000422511.2_Missense_Mutation_p.D367H|ABI2_ENST00000261018.7_Missense_Mutation_p.D186H	NM_001282925.1|NM_001282926.1	NP_001269854.1|NP_001269855.1	Q9NYB9	ABI2_HUMAN	abl-interactor 2		Pro-rich.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding	p.D362Y(1)		breast(1)|kidney(3)|large_intestine(1)|liver(2)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	15						CTTAGTTTCAGATACACCACC	0.458000													7	45					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466469	56466469	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:56466469C>G	ENST00000291971.3	+	3	1116	c.1045C>G	c.(1045-1047)Ccc>Gcc	p.P349A	NLRP8_ENST00000590542.1_Missense_Mutation_p.P349A	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	349	NACHT.					cytoplasm	ATP binding	p.P349T(1)		breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GCTGAAATGTCCCTCTCTCGT	0.453000													16	94					0	0	1	0	0
PASK	23178	broad.mit.edu	37	2	242063472	242063472	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:242063472G>A	ENST00000403638.3	-	11	2887	c.2796C>T	c.(2794-2796)ctC>ctT	p.L932L	PASK_ENST00000234040.4_Silent_p.L932L|PASK_ENST00000358649.4_Silent_p.L932L|PASK_ENST00000544142.1_Silent_p.L746L|PASK_ENST00000539818.1_Silent_p.L716L|PASK_ENST00000405260.1_Silent_p.L932L	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	932					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GGCTGTGGAGGAGGTCTTTCA	0.637000													10	17					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76813007	76813007	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:76813007G>A	ENST00000286719.7	-	3	536	c.180C>T	c.(178-180)gtC>gtT	p.V60V		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	60					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			ATTGTACCTTGACTTGGTCTT	0.587000													7	70					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25432688	25432688	+	RNA	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:25432688G>A	ENST00000424208.1	+	0	761				SNORD115-10_ENST00000365073.1_RNA	NR_003305.1																						GGGTTGGGTCGATGATGAGAA	0.537000													104	270					0	0	1	0	0
CSPG5	10675	broad.mit.edu	37	3	47604191	47604191	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:47604191C>G	ENST00000383738.2	-	5	3698	c.1600G>C	c.(1600-1602)Gag>Cag	p.E534Q	CSPG5_ENST00000456150.1_Missense_Mutation_p.E369Q|CSPG5_ENST00000264723.4_Missense_Mutation_p.E507Q	NM_001206943.1|NM_001206945.1	NP_001193872.1|NP_001193874.1	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan C)	534					cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	22				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TTAAATGACTCCTCCTCTTTC	0.488000													25	154					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70411673	70411673	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:70411673C>T	ENST00000373644.4	+	5	4556	c.4347C>T	c.(4345-4347)gtC>gtT	p.V1449V		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1449					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						TTGCTGCTGTCAGGGAAATCA	0.403000													23	82					0	0	1	0	0
NACAP1	83955	broad.mit.edu	37	8	102381647	102381647	+	RNA	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:102381647G>A	ENST00000419462.1	+	0	1059					NR_002182.1																						CGAAGAGGTCGATGAAACAGG	0.433000													7	55					0	0	1	0	0
STAC	6769	broad.mit.edu	37	3	36587698	36587698	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:36587698G>A	ENST00000273183.3	+	11	1426	c.1126G>A	c.(1126-1128)Gaa>Aaa	p.E376K	STAC_ENST00000457375.2_Missense_Mutation_p.E315K	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	376					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						CGTGAGTTCTGAAGAAGAACA	0.428000													13	95					0	0	1	0	0
GLS2	27165	broad.mit.edu	37	12	56865374	56865374	+	Missense_Mutation	SNP	A	A	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:56865374A>G	ENST00000311966.4	-	18	1984	c.1706T>C	c.(1705-1707)gTc>gCc	p.V569A		NM_013267.2	NP_037399.2	Q9UI32	GLSL_HUMAN	glutaminase 2 (liver, mitochondrial)	569					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AAGCAGTTTGACCACCTCCAG	0.502000													7	71					0	0	1	0	0
ZNF706	51123	broad.mit.edu	37	8	102213962	102213962	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:102213962C>G	ENST00000520347.1	-	2	2964	c.8G>C	c.(7-9)cGt>cCt	p.R3P	ZNF706_ENST00000519882.1_Missense_Mutation_p.R3P|ZNF706_ENST00000517844.1_Missense_Mutation_p.R3P|ZNF706_ENST00000520984.1_Missense_Mutation_p.R3P|ZNF706_ENST00000519744.1_Missense_Mutation_p.R3P|ZNF706_ENST00000518336.1_Missense_Mutation_p.R3P|ZNF706_ENST00000521272.1_Missense_Mutation_p.R3P|ZNF706_ENST00000311212.4_Missense_Mutation_p.R3P			Q9Y5V0	ZN706_HUMAN	zinc finger protein 706	3						intracellular	zinc ion binding	p.R3P(2)		large_intestine(1)|ovary(2)	3	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			CTGCTGTCCACGAGCCATATC	0.398000													7	70					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454471	84454471	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:84454471C>T	ENST00000377084.2	-	1	2057	c.1172G>A	c.(1171-1173)cGa>cAa	p.R391Q		NM_001281503.1|NM_052910.1	NP_001268432.1|NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	391						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GTGCGATTTTCGGATGCTGTG	0.448000													38	135					0	0	1	0	0
GAPVD1	26130	broad.mit.edu	37	9	128113053	128113053	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:128113053G>C	ENST00000470056.1	+	20	3550	c.3390G>C	c.(3388-3390)aaG>aaC	p.K1130N	GAPVD1_ENST00000394104.2_Missense_Mutation_p.K1175N|GAPVD1_ENST00000394105.2_Missense_Mutation_p.K1184N|GAPVD1_ENST00000394083.2_Missense_Mutation_p.K1109N|GAPVD1_ENST00000312123.9_Missense_Mutation_p.K1136N|GAPVD1_ENST00000265956.4_Missense_Mutation_p.K1149N|GAPVD1_ENST00000297933.6_Missense_Mutation_p.K1157N|GAPVD1_ENST00000495955.1_Missense_Mutation_p.K1175N			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1175					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						TACAAGATAAGAATCTAATGG	0.343000													27	44					0	0	1	0	0
ATPAF1	64756	broad.mit.edu	37	1	47131003	47131003	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:47131003C>G	ENST00000576409.1	-	2	431	c.369G>C	c.(367-369)gaG>gaC	p.E123D	ATPAF1_ENST00000329231.4_Missense_Mutation_p.E123D|EFCAB14_ENST00000544071.1_Missense_Mutation_p.R385T|ATPAF1_ENST00000371937.4_Missense_Mutation_p.E100D|ATPAF1_ENST00000542495.1_5'UTR|ATPAF1_ENST00000525633.1_5'UTR|ATPAF1_ENST00000532925.1_Missense_Mutation_p.E12D|ATPAF1_ENST00000574428.1_Missense_Mutation_p.E100D			Q5TC12	ATPF1_HUMAN	ATP synthase mitochondrial F1 complex assembly factor 1	100					protein complex assembly	mitochondrion	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(4)	8	Acute lymphoblastic leukemia(166;0.155)					CACTGCGTTTCTCCAGGCGGG	0.468000													5	43					0	0	1	0	0
CCNI	10983	broad.mit.edu	37	4	77977120	77977120	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:77977120G>A	ENST00000237654.4	-	5	1030	c.454C>T	c.(454-456)Cat>Tat	p.H152Y	CCNI_ENST00000537948.1_Missense_Mutation_p.H138Y	NM_006835.2	NP_006826.1	Q14094	CCNI_HUMAN	cyclin I	152					spermatogenesis					NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	9						TTTACAATATGAAGAAAATCC	0.313000													11	92					0	0	1	0	0
LY6K	54742	broad.mit.edu	37	8	143782008	143782008	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:143782008G>C	ENST00000522591.1	+	1	119	c.63G>C	c.(61-63)ctG>ctC	p.L21L	LY6K_ENST00000518841.1_Silent_p.L21L|LY6K_ENST00000292430.6_Silent_p.L21L|LY6K_ENST00000519387.1_Silent_p.L21L|LY6K_ENST00000561179.1_Silent_p.L79L			Q17RY6	LY6K_HUMAN	lymphocyte antigen 6 complex, locus K	21						anchored to membrane|cytoplasm|extracellular region|nucleolus|plasma membrane				NS(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)	10	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					ACGCCAACCTGACTGCGAGAC	0.716000													4	6					0	0	1	0	0
AAR2	25980	broad.mit.edu	37	20	34827927	34827927	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:34827927G>A	ENST00000373932.3	+	2	483	c.137G>A	c.(136-138)cGg>cAg	p.R46Q	AAR2_ENST00000397286.3_Missense_Mutation_p.R46Q|AAR2_ENST00000320849.4_Missense_Mutation_p.R46Q	NM_015511.3	NP_056326.2			AAR2 splicing factor homolog (S. cerevisiae)																		CCCAAGTTCCGGGGCGTGAAG	0.547000													4	79					0	0	1	0	0
ST7	7982	broad.mit.edu	37	7	116863026	116863026	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:116863026C>G	ENST00000265437.5	+	16	1964	c.1750C>G	c.(1750-1752)Caa>Gaa	p.Q584E	ST7_ENST00000393449.1_Intron|ST7_ENST00000422922.1_Intron|ST7_ENST00000393443.1_Intron|ST7_ENST00000393446.2_Intron|ST7_ENST00000393451.3_Intron|ST7_ENST00000323984.3_Intron|ST7_ENST00000393444.3_Intron|ST7_ENST00000393447.4_Intron|ST7_ENST00000432298.1_Intron	NM_021908.2	NP_068708.1	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7	584						integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(1)	21	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		tcaacatttccaaaactgaac	0.512000													5	37					0	0	1	0	0
WDR35	57539	broad.mit.edu	37	2	20145726	20145726	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:20145726G>C	ENST00000345530.3	-	17	1814	c.1699C>G	c.(1699-1701)Ctg>Gtg	p.L567V	WDR35_ENST00000281405.4_Missense_Mutation_p.L556V|WDR35_ENST00000416055.2_Missense_Mutation_p.L132V	NM_001006657.1	NP_001006658.1	Q9P2L0	WDR35_HUMAN	WD repeat domain 35	567										breast(1)|endometrium(5)|kidney(8)|large_intestine(8)|lung(16)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGAAAGTCAGAACTCCTGAG	0.368000													21	121					0	0	1	0	0
SLC7A8	23428	broad.mit.edu	37	14	23609766	23609766	+	Silent	SNP	G	G	A	rs139271979		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:23609766G>A	ENST00000316902.7	-	5	1427	c.702C>T	c.(700-702)gtC>gtT	p.V234V	SLC7A8_ENST00000532568.1_5'UTR|SLC7A8_ENST00000469263.1_Silent_p.V234V|SLC7A8_ENST00000529705.2_Silent_p.V129V|SLC7A8_ENST00000453702.1_Silent_p.V31V|SLC7A8_ENST00000422941.2_Intron	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	234					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	AAGCCAGTGCGACGAGGCCGA	0.512000													18	184					0	0	1	0	0
R3HDM4	91300	broad.mit.edu	37	19	902052	902052	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:902052G>A	ENST00000361574.5	-	2	223	c.150C>T	c.(148-150)ttC>ttT	p.F50F	R3HDM4_ENST00000587975.1_Silent_p.F29F	NM_138774.3	NP_620129.2	Q96D70	CS022_HUMAN	R3H domain containing 4	50						nucleus	nucleic acid binding										CCTGGTTGATGAAGTGCTGTT	0.672000													8	98					0	0	1	0	0
ZNF354A	6940	broad.mit.edu	37	5	178139578	178139578	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:178139578C>G	ENST00000335815.2	-	5	1498	c.1301G>C	c.(1300-1302)gGa>gCa	p.G434A		NM_005649.2	NP_005640.2	O60765	Z354A_HUMAN	zinc finger protein 354A	434					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(7)|lung(3)|ovary(2)|skin(2)|stomach(2)	19	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		AAACTTCTCTCCAGTATGAAT	0.368000													19	96					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64973898	64973898	+	Missense_Mutation	SNP	T	T	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:64973898T>A	ENST00000399262.2	-	8	2247	c.2029A>T	c.(2029-2031)Ata>Tta	p.I677L	JMJD1C_ENST00000402544.1_Missense_Mutation_p.I458L|JMJD1C_ENST00000399251.1_Missense_Mutation_p.I458L|JMJD1C_ENST00000542921.1_Missense_Mutation_p.I495L	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	677					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TCATGTTCTATCTTATTTGCC	0.363000													17	85					0	0	1	0	0
ATAT1	79969	broad.mit.edu	37	6	30614248	30614248	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:30614248C>G	ENST00000330083.5	+	13	1376	c.1058C>G	c.(1057-1059)tCt>tGt	p.S353C	ATAT1_ENST00000376478.2_Missense_Mutation_p.S342C|ATAT1_ENST00000468713.1_3'UTR|ATAT1_ENST00000376485.4_Missense_Mutation_p.S365C	NM_001031722.2	NP_001026892.1	Q5SQI0	ATAT_HUMAN	alpha tubulin acetyltransferase 1	365							tubulin N-acetyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	9						CCTACCAGGTCTGCCAGTGAG	0.557000													5	7					0	0	1	0	0
RSPH4A	345895	broad.mit.edu	37	6	116949361	116949361	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:116949361C>T	ENST00000229554.5	+	3	1628	c.1491C>T	c.(1489-1491)gtC>gtT	p.V497V	RSPH4A_ENST00000368580.4_Intron|RSPH4A_ENST00000368581.4_Silent_p.V497V	NM_001010892.2	NP_001010892.1	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A (Chlamydomonas)	497					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke				breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GAACCCACGTCAGTCCTCTAG	0.468000									Kartagener syndrome				7	75					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26951260	26951260	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:26951260G>C	ENST00000528896.2	-	25	4817	c.4743C>G	c.(4741-4743)gtC>gtG	p.V1581V	KIAA0100_ENST00000544884.1_Silent_p.V1438V|KIAA0100_ENST00000389003.3_Silent_p.V1438V	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	1581						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					CCTGACAGTTGACCAATTCAA	0.443000													14	134					0	0	1	0	0
MTHFD2	10797	broad.mit.edu	37	2	74441331	74441331	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:74441331G>A	ENST00000394053.2	+	8	1095	c.1015G>A	c.(1015-1017)Gtg>Atg	p.V339M	MTHFD2_ENST00000409804.1_Missense_Mutation_p.V211M|RP11-287D1.3_ENST00000451608.2_Intron|MTHFD2_ENST00000394050.3_Missense_Mutation_p.V175M|MTHFD2_ENST00000409601.1_Missense_Mutation_p.V256M|MTHFD2_ENST00000264090.4_Missense_Mutation_p.V237M	NM_006636.3	NP_006627.2	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	339					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	AGAGCGAGAAGTGCTGAAGTC	0.483000													34	34					0	0	1	0	0
FMO4	2329	broad.mit.edu	37	1	171310923	171310923	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:171310923G>A	ENST00000367749.3	+	10	1952	c.1622G>A	c.(1621-1623)aGa>aAa	p.R541K		NM_002022.1	NP_002013.1	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	541					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AAATTGGTGAGAGATAAACTA	0.418000													9	73					0	0	1	0	0
MYL12A	10627	broad.mit.edu	37	18	3253278	3253278	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr18:3253278G>A	ENST00000217652.3	+	2	428	c.33G>A	c.(31-33)aaG>aaA	p.K11K	MYL12A_ENST00000579226.1_Silent_p.K11K|MYL12A_ENST00000536605.1_Silent_p.K11K|MYL12A_ENST00000580887.1_Silent_p.K17K|MYL12A_ENST00000578611.1_Silent_p.K11K	NM_006471.2	NP_006462.1	P19105	ML12A_HUMAN	myosin, light chain 12A, regulatory, non-sarcomeric	11						myosin complex	calcium ion binding|protein binding			NS(1)|kidney(2)|large_intestine(2)	5						CCAAGACCAAGAAGCGCCCTC	0.403000													15	76					0	0	1	0	0
GDPD2	54857	broad.mit.edu	37	X	69647194	69647194	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:69647194G>A	ENST00000453994.2	+	10	1178	c.817G>A	c.(817-819)Gag>Aag	p.E273K	GDPD2_ENST00000538649.1_Missense_Mutation_p.E194K|GDPD2_ENST00000374382.3_Missense_Mutation_p.E273K|GDPD2_ENST00000536730.1_Missense_Mutation_p.E194K|GDPD2_ENST00000472623.1_3'UTR	NM_001171192.1	NP_001164663.1	Q9HCC8	GDPD2_HUMAN	glycerophosphodiester phosphodiesterase domain containing 2	273	GDPD.				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|large_intestine(8)|lung(3)|ovary(2)	22	Renal(35;0.156)					CATGCATGATGAGCACCTCAG	0.572000													16	21					0	0	1	0	0
BLM	641	broad.mit.edu	37	15	91293213	91293213	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:91293213G>A	ENST00000355112.3	+	3	833	c.715G>A	c.(715-717)Gat>Aat	p.D239N	BLM_ENST00000560509.1_Missense_Mutation_p.D239N	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	239					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			GATTTGCATCGATGATGGCCC	0.413000			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				5	65					0	0	1	0	0
CLDN15	24146	broad.mit.edu	37	7	100877609	100877609	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:100877609G>T	ENST00000401528.1	-	3	1457	c.332C>A	c.(331-333)tCc>tAc	p.S111Y	CLDN15_ENST00000308344.5_Missense_Mutation_p.S111Y	NM_001185080.1	NP_001172009.1	P56746	CLD15_HUMAN	claudin 15	111					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	10	Lung NSC(181;0.168)|all_lung(186;0.215)					GGCTTTCCTGGAGAGCTCCAG	0.667000													17	57					0.000422831	0.000440777	1	1	0
CFB	629	broad.mit.edu	37	6	31915602	31915602	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:31915602G>C	ENST00000456570.1	+	17	2303	c.2248G>C	c.(2248-2250)Gag>Cag	p.E750Q	CFB_ENST00000477310.1_Missense_Mutation_p.E599Q|CFB_ENST00000497841.1_3'UTR|CFB_ENST00000556679.1_Missense_Mutation_p.E750Q|CFB_ENST00000425368.2_Missense_Mutation_p.E248Q			P00751	CFAB_HUMAN	complement factor B	248	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						AGTCGATGCTGAGGATGGGCA	0.547000													78	100					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20588619	20588619	+	RNA	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:20588619C>T	ENST00000428453.1	-	0	4131																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TTCTCCTTCTCACACACTGAG	0.403000													6	74					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103442107	103442107	+	Nonsense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:103442107G>C	ENST00000361246.2	-	11	1709	c.1421C>G	c.(1420-1422)tCa>tGa	p.S474*		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	474					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GGCCCGAGATGAGCCGTGGAG	0.542000													28	158					0	0	1	0	0
ACO2	50	broad.mit.edu	37	22	41914570	41914570	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:41914570C>T	ENST00000396512.3	+	8	1118	c.1101C>T	c.(1099-1101)ctC>ctT	p.L367L	ACO2_ENST00000466237.1_3'UTR|ACO2_ENST00000216254.4_Silent_p.L342L			Q99798	ACON_HUMAN	aconitase 2, mitochondrial	342					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(3)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	23						AAATTAACCTCAGTGAGGTGA	0.488000													16	109					0	0	1	0	0
CCR8	1237	broad.mit.edu	37	3	39374151	39374151	+	Missense_Mutation	SNP	C	C	G	rs144913149	byFrequency	TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:39374151C>G	ENST00000326306.4	+	2	467	c.329C>G	c.(328-330)tCt>tGt	p.S110C	CCR8_ENST00000545843.1_Missense_Mutation_p.S27C|CCR8_ENST00000414803.1_Silent_p.V52V	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	110					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		AAAGTGGTGTCTGGCTTTTAT	0.493000													49	232					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75969093	75969093	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:75969093C>G	ENST00000308508.5	-	10	5859	c.5767G>C	c.(5767-5769)Gat>Cat	p.D1923H	CTD-2026K11.1_ENST00000569467.1_RNA	NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1923	Cysteine-containing.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						CTGGCCCCATCAGACATGCTC	0.662000													10	41					0	0	1	0	0
TLR6	10333	broad.mit.edu	37	4	38830143	38830143	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:38830143G>A	ENST00000436693.2	-	2	1071	c.952C>T	c.(952-954)Ctg>Ttg	p.L318L	TLR6_ENST00000381950.1_Silent_p.L318L	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	318					activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGTGAAAACAGAAAAACTTGG	0.333000													13	49					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34091616	34091616	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:34091616G>A	ENST00000397527.1	+	30	6139	c.5419G>A	c.(5419-5421)Gag>Aag	p.E1807K	CEP250_ENST00000342580.4_Missense_Mutation_p.E1751K	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1807	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TCAACTGGATGAGGCCCAGAG	0.597000													8	76					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90503615	90503615	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:90503615C>G	ENST00000369393.3	-	5	836	c.721G>C	c.(721-723)Gaa>Caa	p.E241Q	MDN1_ENST00000428876.1_Missense_Mutation_p.E241Q			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	241					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGGGAGACTTCTGGATTGGCC	0.502000													8	38					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7949268	7949268	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:7949268G>C	ENST00000309838.2	-	1	941	c.942C>G	c.(940-942)atC>atG	p.I314M		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	314					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AACACAGTCAGATTGTGTGTA	0.363000													10	62					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71623368	71623368	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:71623368G>A	ENST00000541509.1	+	14	1697	c.1508G>A	c.(1507-1509)tGa>tAa	p.*503*	PIP5K1B_ENST00000265382.3_3'UTR	NM_001278253.1	NP_001265182.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	0						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		CCCAGTAAGTGAAAATGGTGA	0.468000													30	51					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117043973	117043973	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:117043973G>C	ENST00000371876.1	-	4	2925	c.504C>G	c.(502-504)gtC>gtG	p.V168V	KLHL13_ENST00000539496.1_Silent_p.V222V|KLHL13_ENST00000469946.1_Silent_p.V168V|KLHL13_ENST00000545703.1_Silent_p.V177V|KLHL13_ENST00000541812.1_Silent_p.V203V|KLHL13_ENST00000540167.1_Silent_p.V203V|KLHL13_ENST00000371878.1_Silent_p.V168V|KLHL13_ENST00000371882.1_Silent_p.V168V|KLHL13_ENST00000262820.3_Silent_p.V219V			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	219					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AATTCTTCAAGACGAAACTGT	0.423000													32	30					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232397	71232397	+	Nonsense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:71232397C>G	ENST00000359042.2	+	3	970	c.776C>G	c.(775-777)tCa>tGa	p.S259*	C17orf80_ENST00000582793.1_Intron|C17orf80_ENST00000268942.8_Nonsense_Mutation_p.S259*|C17orf80_ENST00000426147.2_Nonsense_Mutation_p.S259*|C17orf80_ENST00000255557.4_Nonsense_Mutation_p.S259*|C17orf80_ENST00000535032.2_Nonsense_Mutation_p.S259*|C17orf80_ENST00000577615.1_Nonsense_Mutation_p.S259*|FAM104A_ENST00000583178.1_Intron	NM_017941.4	NP_060411	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	259						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			GATCACCTCTCAGGAGTCCCT	0.398000													17	50					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144993498	144993498	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:144993498C>G	ENST00000322810.4	-	32	11071	c.10902G>C	c.(10900-10902)gaG>gaC	p.E3634D	PLEC_ENST00000356346.3_Missense_Mutation_p.E3483D|PLEC_ENST00000354958.2_Missense_Mutation_p.E3475D|PLEC_ENST00000354589.3_Missense_Mutation_p.E3497D|PLEC_ENST00000436759.2_Missense_Mutation_p.E3524D|PLEC_ENST00000527096.1_Missense_Mutation_p.E3520D|PLEC_ENST00000398774.2_Missense_Mutation_p.E3465D|PLEC_ENST00000345136.3_Missense_Mutation_p.E3497D|PLEC_ENST00000357649.2_Missense_Mutation_p.E3501D	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3634	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CGCGGTTCATCTCCTCACTGA	0.657000													22	99					0	0	1	0	0
SBNO1	55206	broad.mit.edu	37	12	123782565	123782565	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:123782565C>G	ENST00000420886.2	-	30	3998	c.3999G>C	c.(3997-3999)caG>caC	p.Q1333H	SBNO1_ENST00000267176.4_Missense_Mutation_p.Q1332H|SBNO1_ENST00000602398.1_Missense_Mutation_p.Q1333H|SBNO1_ENST00000602750.1_Missense_Mutation_p.Q1332H	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1333							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		GCCGCACGATCTGCATCTTCA	0.433000													12	111					0	0	1	0	0
PRPF3	9129	broad.mit.edu	37	1	150318945	150318945	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:150318945G>C	ENST00000324862.6	+	14	1986	c.1821G>C	c.(1819-1821)caG>caC	p.Q607H	PRPF3_ENST00000467329.1_3'UTR|PRPF3_ENST00000414970.2_Missense_Mutation_p.Q558H	NM_004698.2	NP_004689.1	O43395	PRPF3_HUMAN	pre-mRNA processing factor 3	607					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		GGGATGAACAGACATCTAACA	0.473000													8	70					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31146188	31146188	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:31146188C>T	ENST00000304166.4	+	16	1586	c.1297C>T	c.(1297-1299)Ccg>Tcg	p.P433S	ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.P412S|ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.P461S|ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.P489S	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	433					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						GCACCGACACCCGTCTCTGGC	0.587000													6	49					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28267711	28267711	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:28267711G>A	ENST00000354638.3	-	6	737	c.582C>T	c.(580-582)ttC>ttT	p.F194F	OCA2_ENST00000382996.2_Silent_p.F194F|OCA2_ENST00000353809.5_Silent_p.F194F	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	194					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GATATAGGCTGAACAAAATCT	0.443000									Oculocutaneous Albinism				13	19					0	0	1	0	0
C15orf39	56905	broad.mit.edu	37	15	75498895	75498895	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:75498895C>T	ENST00000360639.2	+	2	826	c.506C>T	c.(505-507)tCa>tTa	p.S169L	C15orf39_ENST00000394987.4_Missense_Mutation_p.S169L|C15orf39_ENST00000567617.1_Missense_Mutation_p.S169L			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	169										autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						CTGTTGCCCTCAGCTGACCCA	0.617000													15	57					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39001179	39001179	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:39001179G>T	ENST00000355481.4	+	59	9105	c.8974G>T	c.(8974-8976)Gaa>Taa	p.E2992*	RYR1_ENST00000360985.3_Nonsense_Mutation_p.E2992*|RYR1_ENST00000359596.3_Nonsense_Mutation_p.E2992*	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2992					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTCCCCACATGAACAGGAGAT	0.557000													16	64					0.000566183	0.000588651	1	1	0
C14orf39	317761	broad.mit.edu	37	14	60936346	60936346	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:60936346C>G	ENST00000321731.3	-	8	739	c.580G>C	c.(580-582)Gat>Cat	p.D194H		NM_174978.2	NP_777638	Q08AQ4	Q08AQ4_HUMAN	chromosome 14 open reading frame 39	194										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		TTAAGAATATCTTGTGTTTCA	0.254000													14	77					0	0	1	0	0
AZI2	64343	broad.mit.edu	37	3	28379434	28379434	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:28379434G>A	ENST00000479665.1	-	4	964	c.433C>T	c.(433-435)Cag>Tag	p.Q145*	AZI2_ENST00000457172.1_Nonsense_Mutation_p.Q145*|AZI2_ENST00000295748.3_5'UTR|AZI2_ENST00000420543.2_Nonsense_Mutation_p.Q145*|AZI2_ENST00000334100.6_Nonsense_Mutation_p.Q145*	NM_022461.3	NP_071906.1	Q9H6S1	AZI2_HUMAN	5-azacytidine induced 2	145						mitochondrion|plasma membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15						ATACCCTGCTGAGTTTCCACC	0.333000													23	52					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157665317	157665317	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:157665317C>T	ENST00000368184.3	-	8	1504	c.1213G>A	c.(1213-1215)Gag>Aag	p.E405K	FCRL3_ENST00000368186.5_Missense_Mutation_p.E405K|FCRL3_ENST00000473231.1_5'UTR|RP11-367J7.3_ENST00000453692.1_RNA	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	405	Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					CTCAGGGACTCACAGTGAAGC	0.592000													35	60					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33146470	33146470	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:33146470C>T	ENST00000341947.2	-	18	1932	c.1705G>A	c.(1705-1707)Gag>Aag	p.E569K	COL11A2_ENST00000395197.1_Missense_Mutation_p.E509K|COL11A2_ENST00000374712.1_Missense_Mutation_p.E488K|COL11A2_ENST00000361917.1_Missense_Mutation_p.E462K|COL11A2_ENST00000357486.1_Missense_Mutation_p.E548K|COL11A2_ENST00000374714.1_Missense_Mutation_p.E543K|COL11A2_ENST00000374713.1_Missense_Mutation_p.E522K|COL11A2_ENST00000374708.4_Missense_Mutation_p.E483K	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	569	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TGGCCCTTCTCTCCAGGGAGC	0.557000													20	114					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19213751	19213751	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:19213751G>C	ENST00000263200.10	-	12	2010	c.1938C>G	c.(1936-1938)ctC>ctG	p.L646L	CLTCL1_ENST00000353891.5_Silent_p.L646L|CLTCL1_ENST00000427926.1_Silent_p.L646L	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	646	Heavy chain arm.|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					CCTCGGGATTGAGGAGGTGAG	0.537000			T	?	ALCL								8	20					0	0	1	0	0
KPNA2	3838	broad.mit.edu	37	17	66033495	66033495	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:66033495G>C	ENST00000537025.2	+	3	717	c.97G>C	c.(97-99)Gag>Cag	p.E33Q	KPNA2_ENST00000330459.3_Missense_Mutation_p.E33Q			P52292	IMA2_HUMAN	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	33	IBB.				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|kidney(2)|lung(9)|prostate(1)|urinary_tract(2)	22	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TCGCAGAATAGAGGTCAATGT	0.428000													32	71					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80887349	80887349	+	Silent	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:80887349G>T	ENST00000355528.4	+	32	3094	c.2964G>T	c.(2962-2964)gtG>gtT	p.V988V	TBCD_ENST00000539345.2_Silent_p.V988V	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D	988					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			GGCTAGTCGTGTCCCTGGGCG	0.672000													17	30					8.28177e-16	9.40675e-16	1	1	0
XKR4	114786	broad.mit.edu	37	8	56015176	56015176	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:56015176G>A	ENST00000327381.6	+	1	228	c.128G>A	c.(127-129)gGa>gAa	p.G43E		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4							integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TCGGGGTCGGGAGCCGAGGAC	0.726000													7	26					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95570086	95570086	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:95570086G>A	ENST00000526495.1	-	23	3938	c.3647C>T	c.(3646-3648)tCa>tTa	p.S1216L	DICER1_ENST00000343455.3_Missense_Mutation_p.S1216L|DICER1_ENST00000541352.1_Missense_Mutation_p.S1216L|DICER1_ENST00000556045.1_Missense_Mutation_p.S114L|DICER1_ENST00000393063.1_Missense_Mutation_p.S1216L|DICER1_ENST00000527414.1_Missense_Mutation_p.S1216L			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1216					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AATGGAATATGAGGTAGTTGG	0.403000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				29	70					0	0	1	0	0
KCNRG	283518	broad.mit.edu	37	13	50594549	50594549	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:50594549G>C	ENST00000312942.1	+	2	1018	c.778G>C	c.(778-780)Gag>Cag	p.E260Q	TRIM13_ENST00000478111.1_3'UTR|KCNRG_ENST00000360473.4_3'UTR	NM_173605.1	NP_775876.1	Q8N5I3	KCNRG_HUMAN	potassium channel regulator	260						voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)	9		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.48e-10)|COAD - Colon adenocarcinoma(199;0.204)		ACCAAAACCAGAGACTATCAT	0.353000													16	102					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181548263	181548263	+	Silent	SNP	T	T	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:181548263T>A	ENST00000526775.1	+	5	837	c.672T>A	c.(670-672)atT>atA	p.I224I	CACNA1E_ENST00000357570.5_Silent_p.I175I|CACNA1E_ENST00000358338.5_Silent_p.I175I|CACNA1E_ENST00000367570.1_Silent_p.I224I|CACNA1E_ENST00000360108.3_Silent_p.I224I|CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000367573.2_Silent_p.I224I	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	224					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TTCTGCAGATTGGCCTTCTGC	0.468000													51	111					0	0	1	0	0
KIF9	64147	broad.mit.edu	37	3	47324545	47324545	+	Translation_Start_Site	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:47324545G>C	ENST00000265529.3	-	0	115				KLHL18_ENST00000232766.5_Missense_Mutation_p.E30D|KLHL18_ENST00000455924.2_5'UTR|KLHL18_ENST00000483201.1_3'UTR			Q9HAQ2	KIF9_HUMAN	kinesin family member 9						blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(15)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)	34		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TCATGGAGGAGATCCGGCGGC	0.662000													3	7					0	0	1	0	0
SLC6A15	55117	broad.mit.edu	37	12	85255590	85255590	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:85255590C>T	ENST00000266682.5	-	12	2555	c.2014G>A	c.(2014-2016)Gat>Aat	p.D672N	SLC6A15_ENST00000552192.1_Missense_Mutation_p.D565N|SLC6A15_ENST00000309283.7_3'UTR	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	672					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						CTTGTATCATCGCCCTCTAAG	0.423000													30	144					0	0	1	0	0
PLK1	5347	broad.mit.edu	37	16	23693416	23693416	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:23693416G>C	ENST00000300093.4	+	4	865	c.754G>C	c.(754-756)Gag>Cag	p.E252Q		NM_005030.3	NP_005021.2	P53350	PLK1_HUMAN	polo-like kinase 1	252	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		ACCACCTTTTGAGACTTCTTG	0.413000													14	64					0	0	1	0	0
LEMD3	23592	broad.mit.edu	37	12	65640104	65640104	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:65640104G>A	ENST00000308330.2	+	13	2761	c.2735G>A	c.(2734-2736)tGa>tAa	p.*912*		NM_001167614.1|NM_014319.4	NP_001161086.1|NP_055134.2	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	0					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	36			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GGAAGTTCCTGAAAAGATTTT	0.343000													13	90					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475520	120475520	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:120475520C>T	ENST00000355622.6	+	3	1215	c.1114C>T	c.(1114-1116)Cta>Tta	p.L372L	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Silent_p.L332L	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	372					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						AGAAGTTGATCTACCAAGCCT	0.378000													19	77					0	0	1	0	0
NMNAT2	23057	broad.mit.edu	37	1	183261927	183261927	+	Silent	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:183261927G>T	ENST00000287713.6	-	3	574	c.240C>A	c.(238-240)atC>atA	p.I80I	NMNAT2_ENST00000294868.4_Silent_p.I75I	NM_015039.3	NP_055854.1	Q9BZQ4	NMNA2_HUMAN	nicotinamide nucleotide adenylyltransferase 2	80					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	18						AGTCCTACCTGATCCAATCAG	0.552000													8	44					0.0477658	0.048195	1	1	0
UPF2	26019	broad.mit.edu	37	10	12043694	12043694	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:12043694C>G	ENST00000356352.2	-	5	2108	c.1635G>C	c.(1633-1635)aaG>aaC	p.K545N	UPF2_ENST00000357604.5_Missense_Mutation_p.K545N|UPF2_ENST00000397053.2_Missense_Mutation_p.K545N			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	545					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				CAAGAAGTTTCTTTGTAAGAT	0.338000													6	75					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410218	105410218	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:105410218G>A	ENST00000333244.5	-	7	11689	c.11570C>T	c.(11569-11571)tCt>tTt	p.S3857F	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3857						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CAGGTCGGCAGAATGGGGCTG	0.637000													43	233					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68255431	68255431	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:68255431G>C	ENST00000262215.3	-	1	481	c.92C>G	c.(91-93)tCc>tGc	p.S31C		NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	31					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GCGCAGCTGGGAGTGATGCGC	0.627000													3	51					0	0	1	0	0
AK8	158067	broad.mit.edu	37	9	135739144	135739144	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:135739144G>T	ENST00000298545.3	-	4	762	c.241C>A	c.(241-243)Ctg>Atg	p.L81M	AK8_ENST00000477396.1_5'UTR	NM_152572.2	NP_689785.1	Q96MA6	KAD8_HUMAN	adenylate kinase 8	81						cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			NS(1)|kidney(2)|large_intestine(4)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(2)	23						CTGCTGTTCAGATGTTTGCAG	0.423000													5	29					0.184627	0.185098	1	1	0
LOC645166	645166	broad.mit.edu	37	1	148933289	148933289	+	RNA	SNP	A	A	G	rs9729175	by1000genomes	TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:148933289A>G	ENST00000539543.1	+	0	176					NR_027355.2																						TGCTGCCCGCAGGATATTGTG	0.562000													5	36					0	0	1	0	0
CCDC167	154467	broad.mit.edu	37	6	37467607	37467607	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:37467607G>A	ENST00000373408.3	-	1	91	c.33C>T	c.(31-33)gtC>gtT	p.V11V		NM_138493.2	NP_612502.1	Q9P0B6	CF129_HUMAN	coiled-coil domain containing 167	11						integral to membrane				endometrium(1)|large_intestine(2)|lung(2)|skin(1)	6						CCTCTAGAGCGACGCCCAGAT	0.577000													13	35					0	0	1	0	0
DHRS7C	201140	broad.mit.edu	37	17	9674975	9674975	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:9674975C>G	ENST00000330255.5	-	6	781	c.769G>C	c.(769-771)Gag>Cag	p.E257Q	DHRS7C_ENST00000571134.1_Missense_Mutation_p.E256Q	NM_001105571.2|NM_001220493.1	NP_001099041.1|NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C							extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						TCCGCCACCTCTACTGGGTGC	0.627000													4	10					0	0	1	0	0
KIAA1598	57698	broad.mit.edu	37	10	118666167	118666167	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:118666167C>T	ENST00000355371.4	-	15	1948	c.1451G>A	c.(1450-1452)aGa>aAa	p.R484K	ENO4_ENST00000369207.2_Intron|KIAA1598_ENST00000260777.10_Intron|KIAA1598_ENST00000392903.2_Missense_Mutation_p.R484K|KIAA1598_ENST00000497044.1_5'UTR|KIAA1598_ENST00000392901.4_Missense_Mutation_p.R424K	NM_001127211.2|NM_001258298.1|NM_001258299.1	NP_001120683.1|NP_001245227.1|NP_001245228.1	A0MZ66	SHOT1_HUMAN	KIAA1598	484					axon guidance	axon				endometrium(1)|kidney(1)|large_intestine(5)|lung(3)	10				all cancers(201;0.00494)		TGTCACCTTTCTGCGACGCAA	0.408000													9	21					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61761012	61761012	+	Nonsense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:61761012C>A	ENST00000577390.1	-	9	2476	c.1522G>T	c.(1522-1524)Gga>Tga	p.G508*	CDH8_ENST00000584337.1_Nonsense_Mutation_p.G508*|CDH8_ENST00000299345.6_Nonsense_Mutation_p.G508*|CDH8_ENST00000577730.1_Nonsense_Mutation_p.G508*	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	508	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CCGGGTTTTCCATTTTCACAT	0.383000													23	84					2.39556e-15	2.71705e-15	1	1	0
ZPBP	11055	broad.mit.edu	37	7	50129261	50129261	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:50129261C>T	ENST00000046087.2	-	2	241	c.172G>A	c.(172-174)Gat>Aat	p.D58N	ZPBP_ENST00000419417.1_Missense_Mutation_p.D58N	NM_001159878.1|NM_007009.2	NP_001153350.1|NP_008940.2	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein	58					binding of sperm to zona pellucida	extracellular region				NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(3)	29	Glioma(55;0.08)|all_neural(89;0.245)					TTCACTGAATCTTTGGTCAAG	0.274000													5	41					0	0	1	0	0
AOC2	314	broad.mit.edu	37	17	40997271	40997271	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:40997271C>T	ENST00000253799.3	+	1	655	c.628C>T	c.(628-630)Cgg>Tgg	p.R210W	AOC2_ENST00000452774.2_Missense_Mutation_p.R210W	NM_009590.2	NP_033720.2	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 (retina-specific)	210					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(14)|ovary(4)|skin(2)	30		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		TGCCACCCCTCGGGGCTTGCG	0.587000													17	98					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55357706	55357706	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:55357706C>G	ENST00000524622.1	-	6	722	c.61G>C	c.(61-63)Gaa>Caa	p.E21Q	TESPA1_ENST00000531122.1_Missense_Mutation_p.E21Q|TESPA1_ENST00000524959.1_5'UTR|TESPA1_ENST00000449076.1_Missense_Mutation_p.E159Q|TESPA1_ENST00000316577.8_Missense_Mutation_p.E159Q|TESPA1_ENST00000532804.1_Missense_Mutation_p.E21Q	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	159																	TCTGCATCTTCTTGCACTTTG	0.453000													16	144					0	0	1	0	0
FBXO18	84893	broad.mit.edu	37	10	5958227	5958227	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:5958227C>T	ENST00000379999.5	+	11	1853	c.1749C>T	c.(1747-1749)ttC>ttT	p.F583F	FBXO18_ENST00000362091.4_Silent_p.F532F|FBXO18_ENST00000397269.3_Silent_p.F19F	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	532					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						TGAATCTCTTCAAGTTAACAC	0.468000													9	71					0	0	1	0	0
NARG2	79664	broad.mit.edu	37	15	60740321	60740321	+	Missense_Mutation	SNP	A	A	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:60740321A>T	ENST00000261520.4	-	11	2377	c.2143T>A	c.(2143-2145)Tat>Aat	p.Y715N	NARG2_ENST00000439632.1_Missense_Mutation_p.Y578N	NM_024611.4	NP_078887.2	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	715						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						TCTTCAACATAGTCCTGAAGT	0.343000													3	55					0	0	1	0	0
GOLGA1	2800	broad.mit.edu	37	9	127644113	127644113	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:127644113C>G	ENST00000373555.4	-	21	2419	c.2086G>C	c.(2086-2088)Gag>Cag	p.E696Q		NM_002077.3	NP_002068	Q92805	GOGA1_HUMAN	golgin A1	696	GRIP.					Golgi cisterna membrane				NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	20						TTAAGGTACTCAAAGTTGATC	0.498000													5	72					0	0	1	0	0
ATP5SL	55101	broad.mit.edu	37	19	41944187	41944187	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:41944187C>T	ENST00000221943.9	-	2	156	c.151G>A	c.(151-153)Gat>Aat	p.D51N	ATP5SL_ENST00000592922.2_Missense_Mutation_p.D51N|ATP5SL_ENST00000595425.1_Missense_Mutation_p.D51N|ATP5SL_ENST00000301183.11_Missense_Mutation_p.D57N|ATP5SL_ENST00000597457.1_Missense_Mutation_p.D51N|ATP5SL_ENST00000417807.3_Missense_Mutation_p.D57N|ATP5SL_ENST00000590641.2_Missense_Mutation_p.D57N|ATP5SL_ENST00000438807.3_Missense_Mutation_p.D51N|ATP5SL_ENST00000589970.1_Missense_Mutation_p.D51N	NM_018035.2	NP_060505.2	Q9NW81	AT5SL_HUMAN	ATP5S-like	51										breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	11						GCCTCCACATCGTAGAAATAG	0.527000													41	96					0	0	1	0	0
BPIFB6	128859	broad.mit.edu	37	20	31625464	31625464	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:31625464C>A	ENST00000349552.1	+	8	766	c.766C>A	c.(766-768)Ctg>Atg	p.L256M		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	256						extracellular region	lipid binding										CTCGTCGCAGCTGCTGCTCCC	0.557000													12	105					2.27111e-07	2.45205e-07	1	1	0
CCDC57	284001	broad.mit.edu	37	17	80136453	80136453	+	Missense_Mutation	SNP	T	T	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:80136453T>C	ENST00000389641.4	-	10	1439	c.1403A>G	c.(1402-1404)cAg>cGg	p.Q468R	CCDC57_ENST00000392347.1_Missense_Mutation_p.Q468R|CCDC57_ENST00000327026.3_5'UTR|CCDC57_ENST00000392343.3_Missense_Mutation_p.Q468R			Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	468										endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	16	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			CTGTAGCGCCTGCTCTGTCTC	0.642000													14	35					0	0	1	0	0
MCCC2	64087	broad.mit.edu	37	5	70945948	70945948	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:70945948G>C	ENST00000340941.6	+	15	1555	c.1426G>C	c.(1426-1428)Gag>Cag	p.E476Q	MCCC2_ENST00000323375.8_Missense_Mutation_p.E438Q	NM_022132.4	NP_071415.1	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-CoA carboxylase 2 (beta)	476	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			endometrium(2)|kidney(15)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	30		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	GATGGGAGGAGAGCAGGCAGC	0.458000													5	52					0	0	1	0	0
EIF4B	1975	broad.mit.edu	37	12	53421930	53421930	+	Silent	SNP	A	A	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:53421930A>C	ENST00000262056.9	+	8	1263	c.937A>C	c.(937-939)Aga>Cga	p.R313R	EIF4B_ENST00000420463.3_Silent_p.R313R|EIF4B_ENST00000416762.3_Silent_p.R274R|RP11-983P16.4_ENST00000552905.1_RNA	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	313	Arg-rich.|Asp-rich.				insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						GTGGAGCTCCAGAGATGATTA	0.473000													5	53					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53571361	53571361	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:53571361C>G	ENST00000601421.1	-	3	3194	c.2318G>C	c.(2317-2319)aGa>aCa	p.R773T	ZNF160_ENST00000429604.1_Missense_Mutation_p.R809T|ZNF160_ENST00000418871.1_Missense_Mutation_p.R809T|ZNF160_ENST00000599056.1_Missense_Mutation_p.R809T			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	809					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		GGTATGCATTCTGTGATGACT	0.408000													22	142					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84666306	84666306	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:84666306C>T	ENST00000284136.6	-	10	1133	c.1090G>A	c.(1090-1092)Gac>Aac	p.D364N	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	364	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						GCTCTGATGTCAGCCATGCTA	0.413000													10	69					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45812744	45812744	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:45812744G>A	ENST00000358525.4	-	6	1015	c.900C>T	c.(898-900)ttC>ttT	p.F300F	SLC6A20_ENST00000353278.4_Silent_p.F263F|SLC6A20_ENST00000456124.2_Silent_p.F300F	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	300					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		AGGTGGCCTTGAAGCCATAGA	0.537000													18	43					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28143169	28143169	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:28143169C>G	ENST00000316334.3	-	3	781	c.652G>C	c.(652-654)Gac>Cac	p.D218H		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	218							zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CACATACTGTCAGCTCCAGCG	0.473000													18	130					0	0	1	0	0
ART3	419	broad.mit.edu	37	4	77003553	77003553	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:77003553G>C	ENST00000355810.4	+	3	765	c.646G>C	c.(646-648)Gat>Cat	p.D216H	ART3_ENST00000341029.5_Missense_Mutation_p.D216H|ART3_ENST00000349321.3_Missense_Mutation_p.D216H|ART3_ENST00000513494.1_3'UTR	NM_001130016.2	NP_001123488.1	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3	216					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|stomach(1)	16			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AAATTTTCTTGATAAAGAAAG	0.388000													14	53					0	0	1	0	0
TPP2	7174	broad.mit.edu	37	13	103295664	103295664	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:103295664G>C	ENST00000376052.3	+	17	2129	c.2113G>C	c.(2113-2115)Gaa>Caa	p.E705Q	TPP2_ENST00000376065.4_Missense_Mutation_p.E705Q			P29144	TPP2_HUMAN	tripeptidyl peptidase II	705					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCGAAGCCATGAATTCTATAA	0.363000													7	58					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184129224	184129224	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:184129224G>A	ENST00000403733.3	+	3	559	c.360G>A	c.(358-360)gtG>gtA	p.V120V	WWC2_ENST00000513834.1_Silent_p.V120V|WWC2_ENST00000448232.2_Silent_p.V120V|WWC2_ENST00000378925.3_Silent_p.V22V	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	120										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		TGTACCATGTGAAGGAGCAGA	0.502000													4	31					0	0	1	0	0
ZNF200	7752	broad.mit.edu	37	16	3282848	3282848	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:3282848C>T	ENST00000431561.3	-	3	936	c.324G>A	c.(322-324)ttG>ttA	p.L108L	ZNF200_ENST00000575948.1_Silent_p.L108L|ZNF200_ENST00000396871.4_Silent_p.L108L|ZNF200_ENST00000396870.4_Silent_p.L108L|ZNF200_ENST00000396868.3_Silent_p.L108L|ZNF200_ENST00000414144.2_Silent_p.L108L	NM_001145447.1|NM_003454.3	NP_001138919.1|NP_003445.2	P98182	ZN200_HUMAN	zinc finger protein 200	108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	17						GGTTAGCTTTCAAATACAGAG	0.468000													8	24					0	0	1	0	0
ART3	419	broad.mit.edu	37	4	77003150	77003150	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:77003150G>C	ENST00000355810.4	+	3	362	c.243G>C	c.(241-243)aaG>aaC	p.K81N	ART3_ENST00000341029.5_Missense_Mutation_p.K81N|ART3_ENST00000349321.3_Missense_Mutation_p.K81N|ART3_ENST00000513494.1_3'UTR	NM_001130016.2	NP_001123488.1	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3	81					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|stomach(1)	16			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CAGCCCGAAAGACTCAAATCT	0.413000													19	99					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86890751	86890751	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:86890751C>G	ENST00000373119.4	+	9	2046	c.1901C>G	c.(1900-1902)tCc>tGc	p.S634C	KLHL4_ENST00000373114.4_Missense_Mutation_p.S634C	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	634						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						AACCATTGCTCCAGGCTTTCT	0.388000													10	36					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36384758	36384758	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:36384758C>T	ENST00000373204.4	+	18	2581	c.2368C>T	c.(2368-2370)Cga>Tga	p.R790*	AGO1_ENST00000373206.1_Nonsense_Mutation_p.R715*	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		CACTTACGTACGATGCACACG	0.557000													4	31					0	0	1	0	0
NSUN2	54888	broad.mit.edu	37	5	6620274	6620274	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:6620274C>A	ENST00000264670.6	-	7	1071	c.760G>T	c.(760-762)Gac>Tac	p.D254Y	NSUN2_ENST00000539938.1_Missense_Mutation_p.D18Y|NSUN2_ENST00000506139.1_Missense_Mutation_p.D219Y|NSUN2_ENST00000505264.1_5'UTR	NM_017755.5	NP_060225.4	Q08J23	NSUN2_HUMAN	NOP2/Sun RNA methyltransferase family, member 2	254						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						TTCCTGCCGTCCACATCTATC	0.483000													8	81					5.4927e-09	6.0129e-09	1	1	0
RRAGD	58528	broad.mit.edu	37	6	90090015	90090015	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:90090015G>A	ENST00000369415.4	-	3	792	c.516C>T	c.(514-516)atC>atT	p.I172I	RRAGD_ENST00000492783.1_5'UTR|RRAGD_ENST00000359203.3_Silent_p.I21I	NM_021244.4	NP_067067.1	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	172					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(2)	15		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		CCTCGAAGTTGATGTCAGTAT	0.483000													20	58					0	0	1	0	0
ZNF460	10794	broad.mit.edu	37	19	57803410	57803410	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:57803410G>A	ENST00000360338.3	+	3	1823	c.1501G>A	c.(1501-1503)Gag>Aag	p.E501K	ZNF460_ENST00000537645.1_Missense_Mutation_p.E460K	NM_006635.3	NP_006626.3	Q14592	ZN460_HUMAN	zinc finger protein 460	501					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCACACTGCAGAGAAGTCCCA	0.547000													13	95					0	0	1	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114534	27114534	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:27114534G>C	ENST00000396891.4	-	1	85	c.44C>G	c.(43-45)tCg>tGg	p.S15W	HIST1H2BK_ENST00000356950.1_Missense_Mutation_p.S15W	NM_080593.2	NP_542160.1	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	15					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						GGCTTTCTTCGAGCCCTTCTT	0.572000													17	143					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42564660	42564660	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:42564660C>T	ENST00000359486.3	-	4	6018	c.5882G>A	c.(5881-5883)tGa>tAa	p.*1961*	TCF20_ENST00000335626.4_Intron|TCF20_ENST00000404876.1_Silent_p.*251*	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						CTGCCCCCCTCACCCCCGCTC	0.667000											OREG0026603	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	12					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102738692	102738692	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:102738692G>C	ENST00000210633.3	+	7	808	c.730G>C	c.(730-732)Gag>Cag	p.E244Q	MRPL43_ENST00000318325.2_3'UTR|SEMA4G_ENST00000370250.4_Missense_Mutation_p.E244Q|MRPL43_ENST00000370241.3_3'UTR|SEMA4G_ENST00000517724.1_Missense_Mutation_p.E244Q|SEMA4G_ENST00000519756.1_Intron			Q9NTN9	SEM4G_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	244	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		CTTCTTCACGGAGCGTGCCAC	0.602000													3	37					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175618	140175618	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:140175618C>T	ENST00000526136.1	+	1	1069	c.1069C>T	c.(1069-1071)Ctt>Ttt	p.L357F	PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000378132.1_Missense_Mutation_p.L357F|PCDHA2_ENST00000520672.2_Missense_Mutation_p.L357F|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCTCTCTCACTTCCCATCTC	0.468000													7	63					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67431935	67431935	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:67431935C>T	ENST00000349015.3	-	8	1243	c.805G>A	c.(805-807)Gag>Aag	p.E269K	ALDH3B2_ENST00000530069.1_Missense_Mutation_p.E269K	NM_000695.3	NP_000686	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	269					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	TTGATGGCCTCGTCCACGCTC	0.652000													22	96					0	0	1	0	0
F11R	50848	broad.mit.edu	37	1	160969970	160969970	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:160969970G>C	ENST00000368026.6	-	5	831	c.557C>G	c.(556-558)tCt>tGt	p.S186C	F11R_ENST00000537746.1_Missense_Mutation_p.S137C|F11R_ENST00000289779.3_3'UTR|F11R_ENST00000472573.1_5'UTR	NM_016946.4	NP_058642.1	Q9Y624	JAM1_HUMAN	F11 receptor	186	Ig-like V-type 2.				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)	12	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			GACATAGGAAGAGTTGCTGAA	0.502000													50	91					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128134427	128134427	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:128134427G>A	ENST00000368250.1	-	5	1620	c.1122C>T	c.(1120-1122)ttC>ttT	p.F374F	THEMIS_ENST00000543064.1_Silent_p.F453F|THEMIS_ENST00000368248.2_Silent_p.F453F|THEMIS_ENST00000537166.1_Silent_p.F418F			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	453	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						AGGGCAAACGGAACTGTTTAC	0.488000													14	75					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58723307	58723307	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:58723307G>T	ENST00000300079.5	+	7	859	c.809G>T	c.(808-810)cGa>cTa	p.R270L	GLYATL1_ENST00000317391.4_Missense_Mutation_p.R239L|RP11-142C4.6_ENST00000533954.1_RNA	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	239						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	GAAAAATACCGAAGGACAGGC	0.483000													8	68					0.0381472	0.0385395	1	1	0
UNC50	25972	broad.mit.edu	37	2	99234707	99234707	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:99234707G>A	ENST00000409975.1	+	5	1901	c.771G>A	c.(769-771)ctG>ctA	p.L257L	UNC50_ENST00000409347.1_Silent_p.L257L|UNC50_ENST00000357765.2_Silent_p.L240L			Q53HI1	UNC50_HUMAN	unc-50 homolog (C. elegans)	240					protein transport	Golgi membrane|integral to membrane|nuclear inner membrane	RNA binding			breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)	10						GGCTTTCCCTGGCACTGGGAT	0.388000													11	36					0	0	1	0	0
GYS1	2997	broad.mit.edu	37	19	49481208	49481208	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:49481208C>G	ENST00000323798.3	-	10	1477	c.1281G>C	c.(1279-1281)atG>atC	p.M427I	GYS1_ENST00000544287.1_Missense_Mutation_p.M60I|GYS1_ENST00000541188.1_Missense_Mutation_p.M347I|GYS1_ENST00000263276.6_Missense_Mutation_p.M363I|GYS1_ENST00000540532.1_3'UTR	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	427					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		CTCTCTTCATCATAGTGAAGT	0.542000													12	95					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175628	140175628	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:140175628C>T	ENST00000526136.1	+	1	1079	c.1079C>T	c.(1078-1080)tCa>tTa	p.S360L	PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000378132.1_Missense_Mutation_p.S360L|PCDHA2_ENST00000520672.2_Missense_Mutation_p.S360L|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCCCATCTCAGAGAACGCT	0.488000													8	62					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058910	152058910	+	Silent	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:152058910G>T	ENST00000368806.1	-	3	1312	c.1248C>A	c.(1246-1248)gtC>gtA	p.V416V		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	416							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GGGTTTCCAGGACTAGTGGCC	0.448000													8	252					1.12685e-05	1.20504e-05	1	1	0
ZFP3	124961	broad.mit.edu	37	17	4996162	4996162	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:4996162G>C	ENST00000318833.3	+	2	1699	c.1363G>C	c.(1363-1365)Gag>Cag	p.E455Q		NM_153018.2	NP_694563.1	Q96NJ6	ZFP3_HUMAN	ZFP3 zinc finger protein	455					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(3)|prostate(1)	20						TAGCGAGTGTGAGAAAACATT	0.398000													14	127					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51523771	51523771	+	Nonsense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:51523771G>C	ENST00000371117.3	-	61	11428	c.11153C>G	c.(11152-11154)tCa>tGa	p.S3718*		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3718					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GACTCCCTTTGACTGAGTAAC	0.388000													45	108					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121957806	121957806	+	Silent	SNP	A	A	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:121957806A>T	ENST00000379692.4	-	4	1846	c.1320T>A	c.(1318-1320)acT>acA	p.T440T		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	440										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						ATGACTGCTTAGTAGGCCTTG	0.458000													34	268					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47050035	47050035	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:47050035C>T	ENST00000450053.3	+	52	8083	c.7904C>T	c.(7903-7905)tCa>tTa	p.S2635L	NBEAL2_ENST00000292309.5_Missense_Mutation_p.S2451L|NBEAL2_ENST00000383740.2_Missense_Mutation_p.S884L	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2635							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CACCTGTATTCAGTCAATGGG	0.607000													24	99					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55561232	55561232	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:55561232C>G	ENST00000436346.1	-	15	3566	c.2725G>C	c.(2725-2727)Gag>Cag	p.E909Q	AC012358.8_ENST00000600219.1_RNA|AC012358.8_ENST00000608103.1_RNA|AC012358.8_ENST00000599475.1_RNA|AC012358.8_ENST00000599352.1_RNA|CCDC88A_ENST00000263630.8_Missense_Mutation_p.E909Q|CCDC88A_ENST00000413716.2_Missense_Mutation_p.E909Q|AC012358.8_ENST00000594078.1_RNA|CCDC88A_ENST00000336838.6_Missense_Mutation_p.E909Q	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	909					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						ATATTTACCTCACGTAGTGTA	0.274000													15	34					0	0	1	0	0
TLX3	30012	broad.mit.edu	37	5	170738600	170738600	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:170738600G>A	ENST00000296921.5	+	3	955	c.873G>A	c.(871-873)gtG>gtA	p.V291V		NM_021025.2	NP_066305.2	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	291						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCTCCCTGGTGTGAGCCCACC	0.701000			T	BCL11B	T-ALL								3	7					0	0	1	0	0
TSC22D2	9819	broad.mit.edu	37	3	150127594	150127594	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:150127594C>T	ENST00000361875.3	+	1	1473	c.457C>T	c.(457-459)Cag>Tag	p.Q153*	TSC22D2_ENST00000361136.2_Nonsense_Mutation_p.Q153*	NM_014779.2	NP_055594.1	O75157	T22D2_HUMAN	TSC22 domain family, member 2								sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	18			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			AGCCCCATCTCAGCCTCCCAC	0.677000													12	79					0	0	1	0	0
ZNF793	390927	broad.mit.edu	37	19	38027903	38027903	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:38027903G>A	ENST00000445217.1	+	4	378	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	ZNF793_ENST00000542455.1_Missense_Mutation_p.E115K|ZNF793_ENST00000588578.1_3'UTR|ZNF793_ENST00000587143.1_Missense_Mutation_p.E115K|ZNF793_ENST00000589319.1_Missense_Mutation_p.E115K			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAAAAGCTGTGAATATAATAA	0.423000													6	31					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63930724	63930724	+	Silent	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:63930724C>A	ENST00000443617.2	-	63	12066	c.11979G>T	c.(11977-11979)ctG>ctT	p.L3993L		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	3993					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						ATTTACCTCCCAGGTGCCAGT	0.478000													13	43					2.68362e-12	3.01763e-12	1	1	0
GSE1	23199	broad.mit.edu	37	16	85695087	85695087	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:85695087G>A	ENST00000253458.7	+	9	2152	c.1976G>A	c.(1975-1977)gGa>gAa	p.G659E	GSE1_ENST00000405402.2_Missense_Mutation_p.G555E|GSE1_ENST00000393243.1_Missense_Mutation_p.G586E	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein																		CCACGAGAGGGAGGGAGCCTG	0.701000													5	16					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150923363	150923363	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:150923363C>G	ENST00000261800.5	-	9	7337	c.7325G>C	c.(7324-7326)tGc>tCc	p.C2442S		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2442	Cadherin 21.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGCTTTTTGCAAAGGTTGAA	0.458000													6	51					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142051264	142051264	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:142051264C>T	ENST00000264951.4	-	36	4289	c.4172G>A	c.(4171-4173)aGa>aAa	p.R1391K	XRN1_ENST00000392981.2_Missense_Mutation_p.R1392K	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1391					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						ATATTCATCTCTTCTGTTAGA	0.289000													15	56					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153897151	153897151	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:153897151G>A	ENST00000511601.1	+	12	2896	c.2708G>A	c.(2707-2709)cGc>cAc	p.R903H	FHDC1_ENST00000260008.3_Missense_Mutation_p.R903H			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	903					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GAGAGCATGCGCAAGGTCATG	0.697000													4	35					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64166775	64166775	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:64166775G>A	ENST00000395391.1	+	4	1468	c.93G>A	c.(91-93)ctG>ctA	p.L31L	ZNF107_ENST00000423627.1_Silent_p.L31L|ZNF107_ENST00000344930.3_Silent_p.L31L			Q9UII5	ZN107_HUMAN	zinc finger protein 107	31					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AAGTGACACTGAGAAGATACG	0.348000													12	87					0	0	1	0	0
UMOD	7369	broad.mit.edu	37	16	20362065	20362065	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:20362065C>G	ENST00000396138.4	-	2	208	c.142G>C	c.(142-144)Gaa>Caa	p.E48Q	UMOD_ENST00000396142.2_5'UTR|UMOD_ENST00000302509.4_5'UTR|UMOD_ENST00000570689.1_5'UTR|UMOD_ENST00000424589.1_5'UTR|UMOD_ENST00000396134.2_5'UTR			P07911	UROM_HUMAN	uromodulin	0	EGF-like 1.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						CCCATCCTTTCTGCTCTTCCC	0.517000													4	45					0	0	1	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50462060	50462060	+	Silent	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:50462060C>G	ENST00000447370.2	-	7	1293	c.1203G>C	c.(1201-1203)ctG>ctC	p.L401L	SIGLEC11_ENST00000426971.2_Silent_p.L401L	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	401	Ig-like C2-type 3.				cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		GGGTCCAGCTCAGCCTGGCTG	0.662000													14	65					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57859009	57859009	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:57859009C>G	ENST00000228682.2	+	5	596	c.505C>G	c.(505-507)Cag>Gag	p.Q169E	GLI1_ENST00000543426.1_Missense_Mutation_p.Q41E|GLI1_ENST00000546141.1_Missense_Mutation_p.Q128E	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	169					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding	p.Q169E(1)		NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			CCCACATCCTCAGTCCCGGGG	0.592000													9	34					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173351811	173351811	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:173351811G>C	ENST00000375221.2	+	15	2235	c.2032G>C	c.(2032-2034)Gaa>Caa	p.E678Q	ITGA6_ENST00000409080.1_Missense_Mutation_p.E639Q|ITGA6_ENST00000409532.1_Missense_Mutation_p.E520Q|ITGA6_ENST00000264107.7_Missense_Mutation_p.E639Q|AC093818.1_ENST00000442417.1_RNA|ITGA6_ENST00000264106.6_Missense_Mutation_p.E678Q|ITGA6_ENST00000343713.4_Missense_Mutation_p.E634Q			P23229	ITA6_HUMAN	integrin, alpha 6	678					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			CCTTAAACTAGAATATAAATT	0.343000													15	38					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140724876	140724876	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:140724876G>C	ENST00000253812.6	+	1	1276	c.1276G>C	c.(1276-1278)Gat>Cat	p.D426H	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAGCCTCAGATGGGGGAAG	0.463000													26	89					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45710921	45710921	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr21:45710921C>G	ENST00000355347.4	+	1	232	c.232C>G	c.(232-234)Ctc>Gtc	p.L78V	AIRE_ENST00000291582.5_Intron|AIRE_ENST00000329347.4_Missense_Mutation_p.L78V			O43918	AIRE_HUMAN	autoimmune regulator	273	HSR.		W -> R (in APECED; lack of alpha- galactosidase enzymatic activity; lack of homodimerization).		positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		GGAGGTGGCTCTCAGGAGGGT	0.627000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				9	77					0	0	1	0	0
PDE7A	5150	broad.mit.edu	37	8	66631569	66631569	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:66631569C>G	ENST00000401827.3	-	13	1848	c.1405G>C	c.(1405-1407)Gag>Cag	p.E469Q	PDE7A_ENST00000379419.4_Missense_Mutation_p.E443Q	NM_001242318.2	NP_001229247.1	Q13946	PDE7A_HUMAN	phosphodiesterase 7A	469						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			large_intestine(5)|lung(3)|stomach(1)|urinary_tract(1)	10			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	GAGTTCAACTCAAATGCAGCA	0.483000													5	55					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242148969	242148969	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:242148969C>T	ENST00000274979.8	+	13	1543	c.1440C>T	c.(1438-1440)atC>atT	p.I480I	ANO7_ENST00000402430.3_Silent_p.I479I	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	480						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						CGAACCCCATCACGGGTGAGG	0.701000													6	8					0	0	1	0	0
HR	55806	broad.mit.edu	37	8	21985168	21985168	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:21985168G>A	ENST00000381418.4	-	3	2267	c.787C>T	c.(787-789)Cct>Tct	p.P263S	HR_ENST00000312841.8_Missense_Mutation_p.P263S	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	263							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		AGCGGGCAAGGATTCTGCTGC	0.642000													13	89					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3839580	3839580	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:3839580G>A	ENST00000309890.7	-	16	2655	c.2505C>T	c.(2503-2505)ttC>ttT	p.F835F	ATP2A3_ENST00000397035.3_Silent_p.F835F|ATP2A3_ENST00000397043.3_Silent_p.F835F|ATP2A3_ENST00000397039.1_Silent_p.F19F|ATP2A3_ENST00000359983.3_Silent_p.F835F|ATP2A3_ENST00000397041.3_Silent_p.F835F|ATP2A3_ENST00000352011.3_Silent_p.F835F	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	835					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CCAGGTATCGGAAGAAGAGCC	0.597000													37	50					0	0	1	0	0
ZNF678	339500	broad.mit.edu	37	1	227842306	227842306	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:227842306C>G	ENST00000343776.5	+	4	700	c.355C>G	c.(355-357)Cat>Gat	p.H119D	ZNF678_ENST00000608949.1_Intron|ZNF678_ENST00000397097.3_Missense_Mutation_p.H174D	NM_178549.3	NP_848644.2	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678						regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|pancreas(1)|prostate(1)	24		Prostate(94;0.0885)				TAAGAGAATTCATACTGGAGA	0.338000													26	49					0	0	1	0	0
TFAP2A	7020	broad.mit.edu	37	6	10398662	10398662	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:10398662C>G	ENST00000379613.3	-	7	1564	c.1308G>C	c.(1306-1308)aaG>aaC	p.K436N	TFAP2A_ENST00000379604.2_Missense_Mutation_p.K434N|TFAP2A_ENST00000482890.1_Missense_Mutation_p.K434N|TFAP2A_ENST00000319516.4_Missense_Mutation_p.K430N|TFAP2A_ENST00000379608.3_Missense_Mutation_p.K428N			P05549	AP2A_HUMAN	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	434					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	13	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				ACTTTCTGTGCTTCTCCTCTT	0.632000													39	280					0	0	1	0	0
ADAM15	8751	broad.mit.edu	37	1	155029461	155029461	+	Silent	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:155029461C>A	ENST00000356955.2	+	11	1133	c.1032C>A	c.(1030-1032)tcC>tcA	p.S344S	ADAM15_ENST00000368410.2_Intron|ADAM15_ENST00000368413.1_Intron|ADAM15_ENST00000368412.3_Silent_p.S344S|ADAM15_ENST00000360674.4_Silent_p.S344S|ADAM15_ENST00000531455.1_Silent_p.S354S|ADAM15_ENST00000355956.2_Silent_p.S344S|ADAM15_ENST00000271836.6_Silent_p.S344S|ADAM15_ENST00000472434.1_3'UTR|ADAM15_ENST00000447332.3_Silent_p.S328S|ADAM15_ENST00000449910.2_Silent_p.S344S|ADAM15_ENST00000359280.4_Silent_p.S344S	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	344	Peptidase M12B.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GAGTCGCCTCCTCCATAGCCC	0.622000													15	75					6.31663e-08	6.85755e-08	1	1	0
SLC16A2	6567	broad.mit.edu	37	X	73744291	73744291	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:73744291C>T	ENST00000276033.5	+	3	1061	c.895C>T	c.(895-897)Caa>Taa	p.Q299*	SLC16A2_ENST00000587091.1_Nonsense_Mutation_p.Q225*			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	225						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	CCACTACTTTCAACGCCGCCT	0.547000													8	26					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1262147	1262147	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:1262147G>A	ENST00000447027.1	+	31	4104	c.4046G>A	c.(4045-4047)gGg>gAg	p.G1349E	MUC5B_ENST00000529681.1_Missense_Mutation_p.G1346E			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1346	7 X Cys-rich subdomain repeats.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TGGTACAATGGGCACCGCCCA	0.652000													9	17					0	0	1	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47614908	47614908	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:47614908G>T	ENST00000371917.4	+	25	3298	c.3298G>T	c.(3298-3300)Gat>Tat	p.D1100Y	ARFGEF2_ENST00000493140.1_3'UTR	NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	1100					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TGTGTCCATGGATGAACTGGC	0.517000													24	119					1.64293e-13	1.85538e-13	1	1	0
TMEM56	148534	broad.mit.edu	37	1	95657184	95657184	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:95657184C>T	ENST00000370203.4	+	7	843	c.552C>T	c.(550-552)ttC>ttT	p.F184F	RP11-57H12.6_ENST00000604534.1_Intron|RP11-57H12.3_ENST00000421762.1_RNA|RP11-57H12.3_ENST00000419846.1_RNA	NM_001199679.1|NM_152487.2	NP_001186608.1|NP_689700.1	Q96MV1	TMM56_HUMAN	transmembrane protein 56	184	TLC.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)|urinary_tract(1)	12		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		CAGTAGTATTCTTCATCGTGC	0.378000													29	122					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113355431	113355431	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:113355431G>C	ENST00000452357.2	+	5	1154	c.964G>C	c.(964-966)Gag>Cag	p.E322Q	RP1-71H24.1_ENST00000552784.1_RNA|OAS1_ENST00000202917.5_Missense_Mutation_p.E322Q|OAS1_ENST00000445409.2_Missense_Mutation_p.E322Q|OAS1_ENST00000551241.1_Missense_Mutation_p.E322Q	NM_002534.2	NP_002525.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	322					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						GCTGGCACAAGAGGCTGAGGC	0.582000													18	134					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118501939	118501939	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:118501939G>C	ENST00000361417.2	+	8	2254	c.1843G>C	c.(1843-1845)Gag>Cag	p.E615Q	PHLDB1_ENST00000534672.1_3'UTR|PHLDB1_ENST00000356063.5_Missense_Mutation_p.E615Q	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	615										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CCAGCGCCTGGAGACCATCCT	0.622000													34	154					0	0	1	0	0
FGF1	2246	broad.mit.edu	37	5	141993686	141993686	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:141993686C>T	ENST00000359370.6	-	2	86	c.7G>A	c.(7-9)Gaa>Aaa	p.E3K	AC005592.2_ENST00000414314.1_RNA|FGF1_ENST00000494579.1_Intron|FGF1_ENST00000407758.1_Missense_Mutation_p.E3K|FGF1_ENST00000419524.2_Missense_Mutation_p.E3K|FGF1_ENST00000378046.1_Missense_Mutation_p.E3K|AC005592.2_ENST00000443800.1_RNA|FGF1_ENST00000337706.2_Missense_Mutation_p.E3K|FGF1_ENST00000360966.5_Missense_Mutation_p.E3K	NM_000800.4|NM_001144892.2|NM_001144934.1|NM_001144935.1|NM_001257205.1|NM_001257206.1|NM_001257207.1|NM_001257210.1|NM_001257212.1|NM_033137.2	NP_000791.1|NP_001138364.1|NP_001138406.1|NP_001138407.1|NP_001244134.1|NP_001244135.1|NP_001244136.1|NP_001244139.1|NP_001244141.1|NP_149128.1	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic)	3					angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding			large_intestine(1)|lung(2)	3		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	ATTTCCCCTTCAGCCATGGCT	0.498000													7	54					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14482837	14482837	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:14482837G>C	ENST00000344204.4	+	46	6636	c.6612G>C	c.(6610-6612)aaG>aaC	p.K2204N	TRIO_ENST00000537187.1_Missense_Mutation_p.K2204N	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2204	PH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					TTGATAAAAAGAAGGGCTTCT	0.502000													41	101					0	0	1	0	0
APOBEC4	403314	broad.mit.edu	37	1	183617619	183617619	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:183617619C>G	ENST00000308641.4	-	2	569	c.298G>C	c.(298-300)Gaa>Caa	p.E100Q	APOBEC4_ENST00000481562.1_Intron|RGL1_ENST00000536277.1_Intron|RGL1_ENST00000304685.4_Intron	NM_203454.2	NP_982279.1	Q8WW27	ABEC4_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)	100					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(6)|skin(1)	21						CCATTCATTTCAAAGAGCATT	0.398000													14	152					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72281217	72281217	+	RNA	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:72281217G>A	ENST00000438904.2	-	0	370				TYW1B_ENST00000435769.2_RNA|TYW1B_ENST00000438125.1_RNA			Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										AGTGTATGTCGCAACCAGGAA	0.408000													18	98					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128134259	128134259	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:128134259C>G	ENST00000368250.1	-	5	1788	c.1290G>C	c.(1288-1290)ttG>ttC	p.L430F	THEMIS_ENST00000543064.1_Missense_Mutation_p.L509F|THEMIS_ENST00000368248.2_Missense_Mutation_p.L509F|THEMIS_ENST00000537166.1_Missense_Mutation_p.L474F			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	509	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						CAGTCATATTCAAGCGGCCCA	0.453000													13	77					0	0	1	0	0
ZNF674	641339	broad.mit.edu	37	X	46359822	46359822	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:46359822G>C	ENST00000523374.1	-	6	1412	c.1202C>G	c.(1201-1203)tCt>tGt	p.S401C	ZNF674_ENST00000414387.2_Missense_Mutation_p.S395C	NM_001039891.2|NM_001146291.1|NM_001190417.1	NP_001034980.1|NP_001139763.1|NP_001177346.1	Q2M3X9	ZN674_HUMAN	zinc finger protein 674	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)	2						CTGATGAACAGAGAGGTGTGA	0.408000													16	47					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96602692	96602692	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:96602692G>T	ENST00000371321.3	+	7	1142	c.1060G>T	c.(1060-1062)Gag>Tag	p.E354*	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	354					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TGTGGTGCACGAGGTCCAGAG	0.532000													23	93					3.5997e-14	4.07689e-14	1	1	0
MANBAL	63905	broad.mit.edu	37	20	35929739	35929739	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:35929739G>A	ENST00000373605.3	+	3	885	c.73G>A	c.(73-75)Gga>Aga	p.G25R	MANBAL_ENST00000397151.1_Missense_Mutation_p.G25R|MANBAL_ENST00000397150.1_Missense_Mutation_p.G25R|MANBAL_ENST00000397156.3_Missense_Mutation_p.G25R|MANBAL_ENST00000397152.3_Missense_Mutation_p.G25R|MANBAL_ENST00000373606.3_Missense_Mutation_p.G25R			Q9NQG1	MANBL_HUMAN	mannosidase, beta A, lysosomal-like	25						integral to membrane				large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	6		Myeloproliferative disorder(115;0.00878)				GCTACGGTACGGACTCTTCCT	0.597000													15	76					0	0	1	0	0
HSF4	3299	broad.mit.edu	37	16	67201124	67201124	+	Splice_Site	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:67201124C>G	ENST00000264009.8	+	9	1693	c.728C>G	c.(727-729)tCg>tGg	p.S243W	HSF4_ENST00000517867.1_3'UTR|HSF4_ENST00000421453.1_Splice_Site_p.S243W|HSF4_ENST00000521374.1_Splice_Site_p.S243W|HSF4_ENST00000584272.1_Splice_Site_p.S243W	NM_001040667.2	NP_001035757.1	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4	243					response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		TTCATCCAGTCGGTAGGTTTG	0.562000													12	33					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75982637	75982637	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:75982637C>G	ENST00000308508.5	-	3	861	c.769G>C	c.(769-771)Gag>Cag	p.E257Q		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	257	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						AGGTGGCCCTCAAATATGTCC	0.617000													12	27					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154173482	154173482	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:154173482G>A	ENST00000336314.4	+	6	784	c.760G>A	c.(760-762)Ggt>Agt	p.G254S		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	331							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGATGGGGCTGGTGGGGCGCG	0.706000													10	63					0	0	1	0	0
EAF2	55840	broad.mit.edu	37	3	121575857	121575857	+	Splice_Site	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:121575857G>A	ENST00000273668.2	+	4	409		c.e4-1		EAF2_ENST00000451944.2_Splice_Site	NM_018456.4	NP_060926.2	Q96CJ1	EAF2_HUMAN	ELL associated factor 2						apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)	9				GBM - Glioblastoma multiforme(114;0.0972)		CTTAATTGCAGAGTTGAAGGA	0.323000													10	64					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63473153	63473153	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:63473153C>G	ENST00000322893.7	-	3	503	c.235G>C	c.(235-237)Gag>Cag	p.E79Q	KCNH5_ENST00000394968.1_Missense_Mutation_p.E21Q|KCNH5_ENST00000394964.2_Missense_Mutation_p.E21Q|KCNH5_ENST00000420622.2_Missense_Mutation_p.E79Q	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	79	PAS.				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CTGACTTTCTCAATGGTCTTC	0.353000													12	63					0	0	1	0	0
ASL	435	broad.mit.edu	37	7	65548157	65548157	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:65548157G>A	ENST00000304874.9	+	6	544	c.442G>A	c.(442-444)Gag>Aag	p.E148K	ASL_ENST00000380839.4_Missense_Mutation_p.E148K|ASL_ENST00000395331.3_Missense_Mutation_p.E148K|ASL_ENST00000395332.3_Missense_Mutation_p.E148K	NM_000048.3	NP_000039.2	P04424	ARLY_HUMAN	argininosuccinate lyase	148					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(3)|endometrium(3)|large_intestine(2)|lung(9)|upper_aerodigestive_tract(1)	18					L-Arginine(DB00125)	GGATCGGGCAGAGGCGTGAGT	0.637000													3	28					0	0	1	0	0
CXorf65	158830	broad.mit.edu	37	X	70324223	70324223	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:70324223C>A	ENST00000374251.5	-	5	399	c.351G>T	c.(349-351)gaG>gaT	p.E117D		NM_001025265.2	NP_001020436.1	A6NEN9	CX065_HUMAN	chromosome X open reading frame 65											breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)	10						TTCGTCTCCTCTCCAGGGCAT	0.478000													4	6					1.23904e-05	1.32142e-05	1	1	0
ATF6B	1388	broad.mit.edu	37	6	32085711	32085711	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:32085711C>A	ENST00000375201.4	-	12	1385	c.1340G>T	c.(1339-1341)gGa>gTa	p.G447V	ATF6B_ENST00000375203.3_Missense_Mutation_p.G450V			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	450					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						AGGTTCAACTCCCTGAACTGG	0.627000													8	17					2.17888e-05	2.31745e-05	1	1	0
KIAA0586	9786	broad.mit.edu	37	14	59014596	59014596	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:59014596G>A	ENST00000354386.6	+	34	5081	c.4837G>A	c.(4837-4839)Gag>Aag	p.E1613K	KIAA0586_ENST00000556134.1_Silent_p.L1516L|KIAA0586_ENST00000423743.3_Silent_p.L1487L|KIAA0586_ENST00000261244.5_Silent_p.L1455L	NM_001244189.1	NP_001231118.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	0										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTCAGTCTCTGAGTCTCAGCA	0.547000													14	70					0	0	1	0	0
EPAS1	2034	broad.mit.edu	37	2	46611757	46611757	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:46611757G>A	ENST00000263734.3	+	16	3081	c.2571G>A	c.(2569-2571)ctG>ctA	p.L857L		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	857	CTAD.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CCACGCTCCTGCAAGGAGGGG	0.647000													3	50					0	0	1	0	0
COQ3	51805	broad.mit.edu	37	6	99823857	99823857	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:99823857C>G	ENST00000254759.3	-	5	712	c.688G>C	c.(688-690)Gat>Cat	p.D230H	COQ3_ENST00000369240.1_Intron|COQ3_ENST00000369242.1_Intron	NM_017421.3	NP_059117.3	Q9NZJ6	COQ3_HUMAN	coenzyme Q3 methyltransferase	230					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			cervix(1)|lung(5)|upper_aerodigestive_tract(2)	8		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		GTTTCTAGATCAATCACATGT	0.378000													18	65					0	0	1	0	0
WRAP53	55135	broad.mit.edu	37	17	7606646	7606646	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:7606646G>T	ENST00000316024.5	+	10	3837	c.1489G>T	c.(1489-1491)Gag>Tag	p.E497*	WRAP53_ENST00000396463.2_Nonsense_Mutation_p.E497*|WRAP53_ENST00000457584.2_Nonsense_Mutation_p.E497*|WRAP53_ENST00000431639.2_Nonsense_Mutation_p.E497*|WRAP53_ENST00000534050.1_Nonsense_Mutation_p.E464*			Q9BUR4	WAP53_HUMAN	WD repeat containing, antisense to TP53	497				E -> G (in Ref. 2; BAG51781).	positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(2)	18						CGAAGGAGAGGAGCTGGGCCT	0.642000													6	53					0.00198382	0.00203296	1	1	0
GCKR	2646	broad.mit.edu	37	2	27745440	27745440	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:27745440G>C	ENST00000264717.2	+	18	1749	c.1686G>C	c.(1684-1686)caG>caC	p.Q562H	GCKR_ENST00000424318.2_Missense_Mutation_p.Q372H	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	562					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					GCCATGTCCAGGTTGCACATG	0.522000													43	51					0	0	1	0	0
SOD2	6648	broad.mit.edu	37	6	160109251	160109251	+	Missense_Mutation	SNP	G	G	C	rs11575993		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:160109251G>C	ENST00000538183.2	-	3	410	c.250C>G	c.(250-252)Ctt>Gtt	p.L84V	SOD2_ENST00000367054.2_Intron|SOD2_ENST00000337404.4_Intron|SOD2_ENST00000367055.4_Missense_Mutation_p.L84V|SOD2_ENST00000546087.1_Missense_Mutation_p.L38V|SOD2_ENST00000444946.2_Missense_Mutation_p.L84V	NM_000636.2	NP_000627.2	P04179	SODM_HUMAN	superoxide dismutase 2, mitochondrial						age-dependent response to reactive oxygen species|negative regulation of neuron apoptosis|oxygen homeostasis|protein homotetramerization|regulation of transcription from RNA polymerase II promoter|release of cytochrome c from mitochondria|removal of superoxide radicals|vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure		manganese ion binding|superoxide dismutase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(3)|skin(1)	14		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.103)		OV - Ovarian serous cystadenocarcinoma(65;1.4e-18)|BRCA - Breast invasive adenocarcinoma(81;5.77e-06)		GCAGGCTGAAGAGCTATCTGG	0.388000													14	110					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150737372	150737372	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:150737372C>T	ENST00000358849.4	+	10	1328	c.1235C>T	c.(1234-1236)tCt>tTt	p.S412F	ABCB8_ENST00000542328.1_Missense_Mutation_p.S324F|ABCB8_ENST00000356058.4_Silent_p.L450L|ABCB8_ENST00000297504.6_Missense_Mutation_p.S429F|ABCB8_ENST00000498578.1_Missense_Mutation_p.S412F	NM_001282291.1|NM_001282293.1|NM_007188.3	NP_001269220.1|NP_001269222.1|NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	429	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCCAACCTCTCTGTCCTGTTT	0.612000													15	130					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57730541	57730541	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:57730541G>C	ENST00000281282.5	+	2	422	c.344G>C	c.(343-345)aGa>aCa	p.R115T		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	115	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGCCCAATAAGAAACCTGAAA	0.493000													10	70					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	18022456	18022456	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:18022456G>A	ENST00000400573.5	+	16	2565	c.2558G>A	c.(2557-2559)gGa>gAa	p.G853E	CECR2_ENST00000262608.8_Missense_Mutation_p.G854E|CECR2_ENST00000400585.2_Missense_Mutation_p.G712E			Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2						chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		GGGGTGCAGGGAGGGGACTCC	0.642000													13	59					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79840902	79840902	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:79840902G>A	ENST00000360280.3	+	14	1482	c.1222G>A	c.(1222-1224)Gag>Aag	p.E408K	VPS13A_ENST00000376636.3_Missense_Mutation_p.E408K|VPS13A_ENST00000376634.4_Missense_Mutation_p.E408K|VPS13A_ENST00000357409.5_Missense_Mutation_p.E408K	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	408					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GGCAGAAGTTGAGGTAATTCT	0.274000													23	118					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178938934	178938934	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:178938934G>A	ENST00000263967.3	+	14	2333	c.2176G>A	c.(2176-2178)Gaa>Aaa	p.E726K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	726					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E726K(8)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAGAAGGATGAAACACAAAA	0.428000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			5	35					0	0	1	0	0
DKKL1	27120	broad.mit.edu	37	19	49867893	49867893	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:49867893C>G	ENST00000221498.2	+	2	470	c.65C>G	c.(64-66)tCt>tGt	p.S22C	DKKL1_ENST00000594268.1_Intron	NM_014419.3	NP_055234.1	Q9UK85	DKKL1_HUMAN	dickkopf-like 1	22					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity			large_intestine(2)|upper_aerodigestive_tract(1)	3		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)		CTGCTCCTCTCTACCCTGGTG	0.662000													9	48					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123252623	123252623	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:123252623G>C	ENST00000264501.4	+	67	11765	c.11392G>C	c.(11392-11394)Gaa>Caa	p.E3798Q	KIAA1109_ENST00000388738.3_Missense_Mutation_p.E3798Q			Q2LD37	K1109_HUMAN	KIAA1109	3798					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TATACGGGTTGAAATTGATAG	0.383000													15	53					0	0	1	0	0
FKBP3	2287	broad.mit.edu	37	14	45590721	45590721	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:45590721C>A	ENST00000216330.3	-	5	831	c.421G>T	c.(421-423)Gat>Tat	p.D141Y	FKBP3_ENST00000396062.3_Missense_Mutation_p.D141Y			Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	141	PPIase FKBP-type.				protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity			NS(1)|biliary_tract(1)|endometrium(1)|large_intestine(2)|lung(6)|skin(1)	12						ACAGTCCCATCTTGTAGTGTT	0.348000													10	71					3.86212e-05	4.08014e-05	1	1	0
KBTBD4	55709	broad.mit.edu	37	11	47598965	47598965	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:47598965G>A	ENST00000533290.1	-	1	1376	c.662C>T	c.(661-663)tCg>tTg	p.S221L	KBTBD4_ENST00000525720.1_Missense_Mutation_p.S245L|KBTBD4_ENST00000526005.1_Missense_Mutation_p.S196L|KBTBD4_ENST00000395288.2_Missense_Mutation_p.S196L|NDUFS3_ENST00000533507.1_Intron|KBTBD4_ENST00000430070.2_Missense_Mutation_p.S212L			Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	196	BACK.									NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	24						AAACTTACCCGAGATGATATC	0.498000													24	26					0	0	1	0	0
BIN1	274	broad.mit.edu	37	2	127821577	127821577	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:127821577G>C	ENST00000316724.5	-	8	1041	c.630C>G	c.(628-630)atC>atG	p.I210M	BIN1_ENST00000393040.3_Missense_Mutation_p.I179M|BIN1_ENST00000357970.3_Missense_Mutation_p.I210M|BIN1_ENST00000351659.3_Missense_Mutation_p.I210M|BIN1_ENST00000348750.4_Missense_Mutation_p.I179M|BIN1_ENST00000376113.2_Missense_Mutation_p.I179M|BIN1_ENST00000352848.3_Missense_Mutation_p.I179M|BIN1_ENST00000466111.1_5'UTR|BIN1_ENST00000259238.4_Missense_Mutation_p.I179M|BIN1_ENST00000346226.3_Missense_Mutation_p.I179M|BIN1_ENST00000409400.1_Missense_Mutation_p.I179M|BIN1_ENST00000393041.3_Missense_Mutation_p.I179M	NM_139343.2	NP_647593.1	O00499	BIN1_HUMAN	bridging integrator 1	210	BAR.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)	24	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TCTGGGCTTTGATGAGCTCCT	0.657000													11	44					0	0	1	0	0
ZBTB4	57659	broad.mit.edu	37	17	7367107	7367107	+	Silent	SNP	C	C	T	rs141897027	byFrequency	TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:7367107C>T	ENST00000311403.4	-	4	1533	c.1194G>A	c.(1192-1194)gaG>gaA	p.E398E	ZBTB4_ENST00000380599.4_Silent_p.E398E	NM_020899.3	NP_065950.2	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(3)|skin(6)	36		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		TGGGTGTCTTCTCACTGGCAA	0.572000													18	113					0	0	1	0	0
ZNF547	284306	broad.mit.edu	37	19	57889289	57889289	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:57889289G>T	ENST00000282282.3	+	4	1095	c.945G>T	c.(943-945)caG>caT	p.Q315H	AC003002.4_ENST00000597658.1_Intron	NM_173631.2	NP_775902.2	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	315					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTAGACATCAGAGAGTTCACA	0.413000													15	111					2.31682e-05	2.45752e-05	1	1	0
NLRP5	126206	broad.mit.edu	37	19	56552342	56552342	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:56552342C>T	ENST00000390649.3	+	11	2841	c.2841C>T	c.(2839-2841)ctC>ctT	p.L947L		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	947						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CCTCAGCCCTCGTCAGCAACC	0.552000													6	71					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52645825	52645825	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:52645825C>T	ENST00000399231.3	-	27	3841	c.3598G>A	c.(3598-3600)Gaa>Aaa	p.E1200K	MYO5A_ENST00000399233.2_Missense_Mutation_p.E1200K|MYO5A_ENST00000356338.6_Missense_Mutation_p.E1200K|MYO5A_ENST00000358212.6_Missense_Mutation_p.E1200K|MYO5A_ENST00000553916.1_Missense_Mutation_p.E1200K	NM_000259.3	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	1200					actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TATTCCAGTTCTGCACCTCTA	0.353000													7	79					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120796783	120796783	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:120796783G>C	ENST00000369144.3	-	21	3894	c.3767C>G	c.(3766-3768)tCt>tGt	p.S1256C	EIF3A_ENST00000541549.1_Missense_Mutation_p.S1222C	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	1256	Asp-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		CCAGCTTGAAGATTCCTCAGC	0.493000													10	51					0	0	1	0	0
GLMN	11146	broad.mit.edu	37	1	92712659	92712659	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:92712659C>G	ENST00000370360.3	-	18	1709	c.1628G>C	c.(1627-1629)gGa>gCa	p.G543A	GLMN_ENST00000534881.1_Missense_Mutation_p.G529A	NM_053274.2	NP_444504.1	Q92990	GLMN_HUMAN	glomulin, FKBP associated protein	543					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	17		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		GATCTCTTCTCCACTTACAGT	0.358000									Multiple Glomus Tumors (of the Skin), Familial				25	131					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96777540	96777540	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:96777540G>A	ENST00000359933.4	-	28	4968	c.4075C>T	c.(4075-4077)Ctc>Ttc	p.L1359F	ATG2B_ENST00000261834.5_5'UTR	NM_018036.5	NP_060506	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1359										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TACTGAATGAGATTCATTAAC	0.463000													20	144					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167293820	167293820	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:167293820G>T	ENST00000308378.3	-	4	677	c.372C>A	c.(370-372)ttC>ttA	p.F124L	WDR49_ENST00000479765.1_Missense_Mutation_p.F465L|WDR49_ENST00000453925.2_Missense_Mutation_p.F177L	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	124										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						TAAACGAGATGAAAAGTCGTC	0.433000													13	96					9.05144e-12	1.01201e-11	1	1	0
KRT27	342574	broad.mit.edu	37	17	38935997	38935997	+	Silent	SNP	G	G	A	rs139309635	byFrequency	TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:38935997G>A	ENST00000301656.3	-	4	841	c.801C>T	c.(799-801)ctC>ctT	p.L267L		NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	267	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				TCTGCTCTGCGAGGGCTTCGT	0.642000													15	44					0	0	1	0	0
PSORS1C2	170680	broad.mit.edu	37	6	31105959	31105959	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:31105959G>C	ENST00000259845.4	-	2	503	c.180C>G	c.(178-180)ctC>ctG	p.L60L	PSORS1C1_ENST00000259881.9_Intron|PSORS1C1_ENST00000547221.1_Intron	NM_014069.2	NP_054788.2	Q9UIG4	PS1C2_HUMAN	psoriasis susceptibility 1 candidate 2	60						extracellular region				NS(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						GATCTTCAAAGAGAGGGGGTG	0.657000													5	35					0	0	1	0	0
TXNRD1	7296	broad.mit.edu	37	12	104707078	104707078	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:104707078C>G	ENST00000526691.1	+	4	755	c.299C>G	c.(298-300)cCt>cGt	p.P100R	TXNRD1_ENST00000526950.1_Missense_Mutation_p.P117R|TXNRD1_ENST00000427956.1_Missense_Mutation_p.P163R|TXNRD1_ENST00000503506.2_Missense_Mutation_p.P48R|TXNRD1_ENST00000429002.2_Missense_Mutation_p.P198R|TXNRD1_ENST00000397736.2_Missense_Mutation_p.P92R|TXNRD1_ENST00000524698.1_Missense_Mutation_p.P48R|TXNRD1_ENST00000526390.1_Missense_Mutation_p.P92R|TXNRD1_ENST00000529546.1_Missense_Mutation_p.P10R|TXNRD1_ENST00000354940.6_Missense_Mutation_p.P48R|TXNRD1_ENST00000525566.1_Missense_Mutation_p.P198R|TXNRD1_ENST00000540716.1_Missense_Mutation_p.P10R|TXNRD1_ENST00000542918.1_Missense_Mutation_p.P98R|TXNRD1_ENST00000388854.3_Missense_Mutation_p.P100R|TXNRD1_ENST00000378070.4_Missense_Mutation_p.P147R	NM_001261445.1|NM_003330.3	NP_001248374.1|NP_003321.3	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	198	Glutaredoxin.				cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						ACTCCCACCCCTCTTGGAACT	0.423000													6	10					0	0	1	0	0
PXMP4	11264	broad.mit.edu	37	20	32295584	32295584	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:32295584G>C	ENST00000409299.3	-	4	659	c.567C>G	c.(565-567)ctC>ctG	p.L189L	PXMP4_ENST00000344022.3_3'UTR|PXMP4_ENST00000217398.3_3'UTR	NM_007238.4	NP_009169.3	Q9Y6I8	PXMP4_HUMAN	peroxisomal membrane protein 4, 24kDa	189						integral to membrane|membrane fraction|mitochondrial inner membrane|peroxisomal membrane	protein transporter activity			NS(1)|endometrium(2)|large_intestine(2)|lung(8)	13						TGTCCTCATAGAGGTAGGTCA	0.572000													35	129					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1520731	1520731	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:1520731C>T	ENST00000345913.4	+	15	2686	c.2595C>T	c.(2593-2595)ctC>ctT	p.L865L	TPO_ENST00000382198.1_Silent_p.L692L|TPO_ENST00000349624.3_Silent_p.L692L|TPO_ENST00000346956.3_Silent_p.L821L|TPO_ENST00000329066.4_Silent_p.L865L|TPO_ENST00000382201.3_Silent_p.L808L|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000337415.3_Silent_p.L865L	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	865					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TCGCAGGTCTCACCTCGACGG	0.547000													5	46					0	0	1	0	0
PYCRL	65263	broad.mit.edu	37	8	144688028	144688028	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:144688028C>T	ENST00000220966.6	-	6	732	c.703G>A	c.(703-705)Gag>Aag	p.E235K	PYCRL_ENST00000377579.3_Missense_Mutation_p.E86K|PYCRL_ENST00000495276.1_5'UTR	NM_023078.3	NP_075566.2	Q53H96	P5CR3_HUMAN	pyrroline-5-carboxylate reductase-like	223					proline biosynthetic process		pyrroline-5-carboxylate reductase activity			central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)	5	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			TGTTGGCCCTCGTGCAGCAGC	0.697000													4	50					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4920665	4920665	+	Silent	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:4920665G>T	ENST00000433855.1	+	1	2324	c.1458G>T	c.(1456-1458)gcG>gcT	p.A486A	KCNA6_ENST00000280684.3_Silent_p.A486A	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	486						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GGCAGCCTGCGCCGGACCTGA	0.607000										HNSCC(72;0.22)			6	66					0.000157383	0.000164499	1	1	0
ZNF777	27153	broad.mit.edu	37	7	149129916	149129916	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:149129916C>G	ENST00000247930.4	-	6	1770	c.1447G>C	c.(1447-1449)Gag>Cag	p.E483Q		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	483					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			ATACTGGCCTCATATCTCCCG	0.622000													6	14					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134072903	134072903	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:134072903G>A	ENST00000264360.5	+	1	2434	c.1608G>A	c.(1606-1608)ctG>ctA	p.L536L		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10		Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATGAGCAGCTGAAGGACTTCA	0.552000													18	136					0	0	1	0	0
EWSR1	2130	broad.mit.edu	37	22	29684693	29684693	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:29684693G>C	ENST00000397938.2	+	8	1211	c.892G>C	c.(892-894)Gat>Cat	p.D298H	EWSR1_ENST00000332035.6_Missense_Mutation_p.D242H|EWSR1_ENST00000414183.2_Missense_Mutation_p.D304H|EWSR1_ENST00000406548.1_Missense_Mutation_p.D298H|EWSR1_ENST00000331029.7_Missense_Mutation_p.D298H|EWSR1_ENST00000332050.6_Intron|EWSR1_ENST00000333395.6_Missense_Mutation_p.D298H	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	298					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding	p.D298N(1)	EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GAGTGGCCCTGATAACCGGGG	0.587000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								15	70					0	0	1	0	0
LDLRAD2	401944	broad.mit.edu	37	1	22142464	22142464	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:22142464G>A	ENST00000344642.2	+	3	727	c.540G>A	c.(538-540)caG>caA	p.Q180Q	LDLRAD2_ENST00000543870.1_Silent_p.Q180Q	NM_001013693.2	NP_001013715.2	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain containing 2	180	LDL-receptor class A.					integral to membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)	6		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		TCCGCTGCCAGAATGGCAGGT	0.627000													18	50					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111650798	111650798	+	Silent	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:111650798C>A	ENST00000435970.1	-	27	8760	c.7944G>T	c.(7942-7944)ctG>ctT	p.L2648L	REV3L_ENST00000368805.1_Silent_p.L2726L|REV3L_ENST00000368802.3_Silent_p.L2726L|REV3L_ENST00000358835.3_Silent_p.L2726L			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	2726					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CATTTGCTATCAGCTTAAGTC	0.403000								DNA polymerases (catalytic subunits)					21	92					1.22574e-08	1.3381e-08	1	1	0
MET	4233	broad.mit.edu	37	7	116339307	116339307	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:116339307C>G	ENST00000397752.3	+	2	369	c.169C>G	c.(169-171)Cta>Gta	p.L57V	MET_ENST00000318493.6_Missense_Mutation_p.L57V|MET_ENST00000436117.2_Missense_Mutation_p.L57V	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	57	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			GAATGTCATTCTACATGAGCA	0.443000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				12	102					0	0	1	0	0
RHEBL1	121268	broad.mit.edu	37	12	49462822	49462822	+	Silent	SNP	C	C	T	rs150728495		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:49462822C>T	ENST00000301068.6	-	2	359	c.120G>A	c.(118-120)gaG>gaA	p.E40E		NM_144593.1	NP_653194.1	Q8TAI7	REBL1_HUMAN	Ras homolog enriched in brain like 1	40					positive regulation of NF-kappaB transcription factor activity|small GTPase mediated signal transduction|TOR signaling cascade	cytoplasm|plasma membrane	GTP binding|GTPase activity|protein binding			breast(2)|large_intestine(2)|lung(5)	9						ACTCACTATTCTCCACTGTAG	0.507000													19	112					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37464732	37464732	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:37464732G>A	ENST00000299824.1	+	2	353	c.164G>A	c.(163-165)cGc>cAc	p.R55H	PPP1R16B_ENST00000373331.2_Missense_Mutation_p.R55H	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	55					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				GAGCGGAAGCGCAGCACGGGC	0.672000													8	21					0	0	1	0	0
CBX4	8535	broad.mit.edu	37	17	77808556	77808556	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:77808556C>G	ENST00000269397.4	-	5	1062	c.885G>C	c.(883-885)aaG>aaC	p.K295N		NM_003655.2	NP_003646.2	O00257	CBX4_HUMAN	chromobox homolog 4	295	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CTGCCCGCTTCTTGTGGCTGG	0.637000											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	130					0	0	1	0	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22472973	22472973	+	RNA	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:22472973G>T	ENST00000557788.2	-	0	297																											CTCAGCTTCAGGGAGAACTGG	0.552000													32	309					1.45844e-13	1.6494e-13	1	1	0
PRTG	283659	broad.mit.edu	37	15	55970094	55970094	+	Nonsense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:55970094C>A	ENST00000389286.4	-	8	1329	c.1282G>T	c.(1282-1284)Gaa>Taa	p.E428*		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	428	Fibronectin type-III 1.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		GACATGGTTTCAGCATGTACA	0.438000													15	91					2.23348e-06	2.39825e-06	1	1	0
RABEP1	9135	broad.mit.edu	37	17	5235304	5235304	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:5235304G>A	ENST00000262477.6	+	3	448	c.224G>A	c.(223-225)cGa>cAa	p.R75Q	RABEP1_ENST00000537505.1_Missense_Mutation_p.R32Q|RABEP1_ENST00000341923.6_Missense_Mutation_p.R75Q|RABEP1_ENST00000408982.2_Missense_Mutation_p.R75Q|RABEP1_ENST00000546142.2_Missense_Mutation_p.R75Q	NM_004703.4	NP_004694.2	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	75					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	8						GGACACCTTCGAACCCAGCTG	0.423000													14	95					0	0	1	0	0
STOX1	219736	broad.mit.edu	37	10	70645513	70645513	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:70645513C>G	ENST00000298596.6	+	3	2044	c.1961C>G	c.(1960-1962)tCt>tGt	p.S654C	STOX1_ENST00000421961.2_Missense_Mutation_p.S544C|STOX1_ENST00000399165.4_Intron|STOX1_ENST00000399162.2_Intron|STOX1_ENST00000399169.4_Missense_Mutation_p.S654C	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	654						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						CGAACACCCTCTGCTTGTAGA	0.453000													3	100					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135304345	135304345	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:135304345C>G	ENST00000285968.6	+	29	4164	c.4138C>G	c.(4138-4140)Cct>Gct	p.P1380A		NM_015135.2	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1380					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						CTCACCTCCTCCTGAAGAGAA	0.428000													10	69					0	0	1	0	0
MS4A4A	51338	broad.mit.edu	37	11	60070103	60070103	+	Silent	SNP	T	T	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:60070103T>C	ENST00000355131.3	+	6	625	c.402T>C	c.(400-402)ttT>ttC	p.F134F	MS4A4A_ENST00000337908.4_Silent_p.F153F|MS4A4A_ENST00000532114.1_Intron|MS4A4A_ENST00000395016.3_Silent_p.F134F	NM_024021.3	NP_076926.2	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member 4A	153						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(12)|prostate(1)|skin(4)	23						TCAACACATTTAGCTTGGCGT	0.393000													5	180					0	0	1	0	0
CNBD2	140894	broad.mit.edu	37	20	34572561	34572561	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:34572561C>A	ENST00000373973.3	+	6	750	c.577C>A	c.(577-579)Ctg>Atg	p.L193M	CNBD2_ENST00000538900.1_Missense_Mutation_p.L193M|CNBD2_ENST00000349339.1_Missense_Mutation_p.L193M					cyclic nucleotide binding domain containing 2																		AATGGACGTTCTGCATGCTTC	0.537000													9	66					5.4927e-09	6.0129e-09	1	1	0
CHD4	1108	broad.mit.edu	37	12	6709469	6709469	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:6709469C>G	ENST00000309577.6	-	9	1319	c.1156G>C	c.(1156-1158)Gat>Cat	p.D386H	CHD4_ENST00000357008.2_Missense_Mutation_p.D386H|CHD4_ENST00000544040.1_Missense_Mutation_p.D379H|CHD4_ENST00000544484.1_Missense_Mutation_p.D383H			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	386					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GGACAGGTATCACACAGGATG	0.597000													10	78					0	0	1	0	0
LRWD1	222229	broad.mit.edu	37	7	102113218	102113218	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:102113218C>T	ENST00000292616.5	+	14	1922	c.1770C>T	c.(1768-1770)ccC>ccT	p.P590P		NM_152892.1	NP_690852.1	Q9UFC0	LRWD1_HUMAN	leucine-rich repeats and WD repeat domain containing 1	590					chromatin modification|DNA-dependent DNA replication initiation|establishment of protein localization to chromatin|G1 phase of mitotic cell cycle	centromeric heterochromatin|nuclear origin of replication recognition complex|telomeric heterochromatin	chromatin binding|methyl-CpG binding|methylated histone residue binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|stomach(2)	20						AGCAGCCACCCCTGCTGCCGG	0.652000													4	23					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19379666	19379666	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:19379666G>T	ENST00000263208.5	-	9	1150	c.894C>A	c.(892-894)tgC>tgA	p.C298*	HIRA_ENST00000546308.1_Nonsense_Mutation_p.C254*|HIRA_ENST00000340170.4_Nonsense_Mutation_p.C298*|HIRA_ENST00000541063.1_Nonsense_Mutation_p.C254*	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	298					chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					CAGCACAGCAGCAGTACGGGC	0.468000													5	38					0.000157383	0.000164499	1	1	0
MACF1	23499	broad.mit.edu	37	1	39907633	39907633	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:39907633G>C	ENST00000564288.1	+	75	19459	c.18682G>C	c.(18682-18684)Gac>Cac	p.D6228H	MACF1_ENST00000539005.1_Missense_Mutation_p.D4039H|MACF1_ENST00000372915.3_Missense_Mutation_p.D6127H|MACF1_ENST00000545844.1_Missense_Mutation_p.D4169H|MACF1_ENST00000361689.2_Missense_Mutation_p.D4169H|MACF1_ENST00000289893.4_Missense_Mutation_p.D4671H|MACF1_ENST00000567887.1_Missense_Mutation_p.D6265H|MACF1_ENST00000317713.7_Missense_Mutation_p.D4169H			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	6237					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGCTATGTTTGACTGGCTAGA	0.363000													22	75					0	0	1	0	0
SCFD1	23256	broad.mit.edu	37	14	31204796	31204796	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:31204796C>T	ENST00000458591.2	+	25	2137	c.1910C>T	c.(1909-1911)tCa>tTa	p.S637L	SCFD1_ENST00000541123.1_Missense_Mutation_p.S452L|SCFD1_ENST00000396629.2_Missense_Mutation_p.S545L|SCFD1_ENST00000544052.2_Missense_Mutation_p.S570L|RP11-159L20.2_ENST00000554665.1_RNA|SCFD1_ENST00000421551.3_Missense_Mutation_p.S578L	NM_016106.3	NP_057190.2	Q8WVM8	SCFD1_HUMAN	sec1 family domain containing 1	637					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)	13	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		TTTTAGTTGTCACAACTTGGA	0.264000													33	111					0	0	1	0	0
LRR1	122769	broad.mit.edu	37	14	50074507	50074507	+	Silent	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:50074507C>G	ENST00000298288.6	+	3	996	c.672C>G	c.(670-672)ctC>ctG	p.L224L	LRR1_ENST00000318317.4_Intron	NM_152329.3	NP_689542.2	Q96L50	LLR1_HUMAN	leucine rich repeat protein 1	224										kidney(2)|large_intestine(1)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						ATTCTACACTCCAGAAGTCAC	0.433000													32	48					0	0	1	0	0
FAM96B	51647	broad.mit.edu	37	16	66968229	66968229	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:66968229C>G	ENST00000422424.2	-	1	74	c.39G>C	c.(37-39)gaG>gaC	p.E13D		NM_016062.3	NP_057146.1	Q9Y3D0	MIP18_HUMAN	family with sequence similarity 96, member B	13					chromosome segregation	cytoplasm|MMXD complex|nucleus	protein binding			kidney(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		GGTTGGCATTCTCCAGGAGGC	0.692000													5	19					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48605171	48605171	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:48605171G>T	ENST00000328333.8	-	107	8062	c.7955C>A	c.(7954-7956)cCc>cAc	p.P2652H	COL7A1_ENST00000454817.1_Missense_Mutation_p.P2620H	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2652	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGCCAGCCCGGGGCGGCCTGG	0.652000													16	75					2.35188e-11	2.61838e-11	1	1	0
ZBTB49	166793	broad.mit.edu	37	4	4322864	4322864	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:4322864G>A	ENST00000337872.4	+	8	2240	c.2119G>A	c.(2119-2121)Gat>Aat	p.D707N	ZBTB49_ENST00000538529.1_Missense_Mutation_p.D190N|ZBTB49_ENST00000355834.3_Missense_Mutation_p.D585N	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	707					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						ACTGCAGGCCGATGGCATGGC	0.592000													8	55					0	0	1	0	0
MRPL15	29088	broad.mit.edu	37	8	55049831	55049831	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:55049831C>T	ENST00000260102.4	+	3	341	c.267C>T	c.(265-267)ttC>ttT	p.F89F		NM_014175.3	NP_054894.1	Q9P015	RM15_HUMAN	mitochondrial ribosomal protein L15	89					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)|skin(3)	10		Lung NSC(129;0.109)|all_epithelial(80;0.134)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;4.3e-07)|Epithelial(17;5.79e-05)|all cancers(17;0.000458)			TTTACAGTTTCAGACGCCAGT	0.388000													9	87					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64519346	64519346	+	Silent	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:64519346G>T	ENST00000358025.3	+	48	8945	c.8715G>T	c.(8713-8715)ctG>ctT	p.L2905L	SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Silent_p.L2905L|SYNE2_ENST00000554584.1_Silent_p.L2938L	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2905					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATGAGGAGCTGAATGTGTTTG	0.358000													6	22					0.00116845	0.00120367	1	1	0
MCF2	4168	broad.mit.edu	37	X	138708450	138708450	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:138708450G>A	ENST00000520602.1	-	9	1054	c.769C>T	c.(769-771)Cat>Tat	p.H257Y	MCF2_ENST00000370578.4_Missense_Mutation_p.H342Y|MCF2_ENST00000536274.1_Missense_Mutation_p.H158Y|MCF2_ENST00000338585.6_Missense_Mutation_p.H197Y|MCF2_ENST00000370576.4_Missense_Mutation_p.H197Y|MCF2_ENST00000519895.1_Missense_Mutation_p.H257Y|MCF2_ENST00000414978.1_Missense_Mutation_p.H257Y|MCF2_ENST00000370573.4_Missense_Mutation_p.H197Y			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	197					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					TCCATATCATGTACTTGAGTC	0.343000													13	47					0	0	1	0	0
ARHGAP18	93663	broad.mit.edu	37	6	129963118	129963118	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:129963118G>C	ENST00000368149.2	-	2	247	c.159C>G	c.(157-159)atC>atG	p.I53M		NM_033515.2	NP_277050.2	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	53					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		CCATAACTTTGATGGTGGTGC	0.373000													25	96					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215914405	215914405	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:215914405G>C	ENST00000272895.7	-	6	857	c.638C>G	c.(637-639)tCt>tGt	p.S213C		NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	213					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GGTCATGTTAGAAAGGCAAAA	0.373000													15	38					0	0	1	0	0
BRD7	29117	broad.mit.edu	37	16	50402112	50402112	+	Missense_Mutation	SNP	G	G	C	rs145220538	byFrequency	TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:50402112G>C	ENST00000394688.3	-	2	306	c.147C>G	c.(145-147)ttC>ttG	p.F49L	BRD7_ENST00000401491.3_5'UTR|BRD7_ENST00000394689.2_Missense_Mutation_p.F49L			Q9NPI1	BRD7_HUMAN	bromodomain containing 7	49	Lys-rich.				cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(2)	22		all_cancers(37;0.0127)				TTTTGTCTTCGAAGAGGCTGG	0.498000													30	165					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56136502	56136502	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:56136502C>T	ENST00000319441.4	+	2	199	c.35C>T	c.(34-36)tCg>tTg	p.S12L	PCK1_ENST00000543666.1_5'UTR	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	12					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CTGAACCTCTCGGCCAAAGTT	0.547000													19	143					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30937078	30937078	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:30937078C>G	ENST00000597505.1	-	25	3632	c.3633G>C	c.(3631-3633)tgG>tgC	p.W1211C	DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000339794.5_Missense_Mutation_p.W290C			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					CCTGGTGTATCCAGCGCTGAT	0.463000													4	40					0	0	1	0	0
LSS	4047	broad.mit.edu	37	21	47633694	47633694	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr21:47633694G>A	ENST00000397728.3	-	10	1145	c.1067C>T	c.(1066-1068)aCt>aTt	p.T356I	LSS_ENST00000457828.2_Missense_Mutation_p.T276I|LSS_ENST00000522411.1_Missense_Mutation_p.T345I|LSS_ENST00000356396.4_Missense_Mutation_p.T356I	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	356					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					CTGGAAGGCAGTGGAGGCGGG	0.597000													3	14					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95521983	95521983	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:95521983C>A	ENST00000297591.5	-	15	3887	c.3812G>T	c.(3811-3813)gGa>gTa	p.G1271V	KIAA1429_ENST00000437199.1_Missense_Mutation_p.G1271V	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1271					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			AACACTGTCTCCAGGAGACCG	0.358000													7	96					0.00307968	0.00314776	1	1	0
ERMN	57471	broad.mit.edu	37	2	158182010	158182010	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:158182010G>A	ENST00000410096.1	-	1	436	c.145C>T	c.(145-147)Ctg>Ttg	p.L49L	ERMN_ENST00000409925.1_Silent_p.L49L|ERMN_ENST00000409216.1_Silent_p.L49L|ERMN_ENST00000397283.2_Silent_p.L62L|ERMN_ENST00000420719.2_Silent_p.L49L	NM_020711.1	NP_065762.1	Q8TAM6	ERMIN_HUMAN	ermin, ERM-like protein	49						cytoplasm|cytoskeleton				endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12						GCACCTTCCAGACTGGGTTCT	0.453000													13	78					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70550998	70550998	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:70550998G>A	ENST00000260128.4	+	21	3173	c.2456G>A	c.(2455-2457)cGa>cAa	p.R819Q	SULF1_ENST00000402687.4_Missense_Mutation_p.R819Q|SULF1_ENST00000419716.3_Missense_Mutation_p.R819Q|SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000458141.2_Missense_Mutation_p.R819Q	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	819					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			ACGGTAGAACGAGGCATTTTG	0.398000													18	101					0	0	1	0	0
ZNF394	84124	broad.mit.edu	37	7	99097547	99097547	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:99097547G>A	ENST00000337673.6	-	1	373	c.170C>T	c.(169-171)tCg>tTg	p.S57L	ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000493485.1_Intron|ZNF394_ENST00000426306.2_Missense_Mutation_p.S57L|ZNF394_ENST00000394177.3_Intron	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	57					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGGGTCCGGCGAAGCCGCGGG	0.632000													19	52					0	0	1	0	0
CDH19	28513	broad.mit.edu	37	18	64211462	64211462	+	Splice_Site	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr18:64211462C>G	ENST00000262150.2	-	7	1253		c.e7-1		CDH19_ENST00000540086.1_Splice_Site	NM_021153.3	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.?(1)		NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				AATCCACTTTCTGCAAAGAAA	0.378000													5	34					0	0	1	0	0
TRIM13	10206	broad.mit.edu	37	13	50586977	50586977	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:50586977C>G	ENST00000378182.3	+	2	1639	c.901C>G	c.(901-903)Caa>Gaa	p.Q301E	TRIM13_ENST00000420995.2_Missense_Mutation_p.Q301E|TRIM13_ENST00000356017.4_Missense_Mutation_p.Q304E|TRIM13_ENST00000478111.1_Intron|TRIM13_ENST00000457662.2_Missense_Mutation_p.Q301E|TRIM13_ENST00000298772.5_Missense_Mutation_p.Q304E	NM_001007278.1|NM_005798.3|NM_052811.2|NM_213590.1	NP_001007279.1|NP_005789.2|NP_434698.1|NP_998755.1	O60858	TRI13_HUMAN	tripartite motif containing 13	301					anatomical structure morphogenesis|ER-associated protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination	cytoplasm|endoplasmic reticulum membrane|integral to membrane	protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(5)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.53e-10)|COAD - Colon adenocarcinoma(199;0.205)		TTCTTTGCCTCAAGACACTGG	0.408000													26	186					0	0	1	0	0
UFL1	23376	broad.mit.edu	37	6	96999337	96999337	+	Nonsense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:96999337C>G	ENST00000369278.4	+	16	1913	c.1847C>G	c.(1846-1848)tCa>tGa	p.S616*		NM_015323.4	NP_056138.1	O94874	UFL1_HUMAN	UFM1-specific ligase 1	616					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity										AGTAAATTATCAGAAGAAACC	0.299000													8	76					0	0	1	0	0
THOC1	9984	broad.mit.edu	37	18	265325	265325	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr18:265325C>T	ENST00000261600.6	-	3	174	c.167G>A	c.(166-168)aGa>aAa	p.R56K	THOC1_ENST00000582313.1_5'UTR	NM_005131.2	NP_005122.2	Q96FV9	THOC1_HUMAN	THO complex 1	56					apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	20		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				TAGAATACCTCTGAAAGCTTG	0.269000													5	13					0	0	1	0	0
KCNQ4	9132	broad.mit.edu	37	1	41284199	41284199	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:41284199G>A	ENST00000347132.5	+	4	637	c.555G>A	c.(553-555)tcG>tcA	p.S185S	KCNQ4_ENST00000509682.2_Silent_p.S185S	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	185					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TCGTGGCCTCGGTGGCCGTCA	0.692000													5	30					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39264816	39264816	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:39264816C>T	ENST00000280481.7	+	1	3551	c.3335C>T	c.(3334-3336)tCa>tTa	p.S1112L		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1112					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CAGCCTACTTCAGGTTATGTT	0.423000													8	62					0	0	1	0	0
STXBP1	6812	broad.mit.edu	37	9	130416005	130416005	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:130416005G>A	ENST00000373302.3	+	3	238	c.99G>A	c.(97-99)gtG>gtA	p.V33V	STXBP1_ENST00000373299.1_Silent_p.V33V	NM_003165.3	NP_003156.1	P61764	STXB1_HUMAN	syntaxin binding protein 1	33					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|skin(2)	23						TGCTGGTGGTGGATCAGTTAA	0.532000													14	38					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41648549	41648549	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:41648549C>A	ENST00000313860.7	+	12	1358	c.1304C>A	c.(1303-1305)tCc>tAc	p.S435Y	LIMCH1_ENST00000513024.1_Missense_Mutation_p.S264Y|LIMCH1_ENST00000509277.1_Missense_Mutation_p.S269Y|LIMCH1_ENST00000396595.3_Missense_Mutation_p.S281Y|LIMCH1_ENST00000508501.1_Missense_Mutation_p.S435Y|LIMCH1_ENST00000512946.1_Missense_Mutation_p.S435Y|LIMCH1_ENST00000512820.1_Missense_Mutation_p.S423Y|LIMCH1_ENST00000503057.1_Missense_Mutation_p.S820Y|LIMCH1_ENST00000514096.1_Missense_Mutation_p.S276Y|LIMCH1_ENST00000512632.1_Missense_Mutation_p.S435Y|LIMCH1_ENST00000511496.1_Missense_Mutation_p.S276Y|LIMCH1_ENST00000381753.4_Missense_Mutation_p.S269Y	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	435					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						AACGCTCGGTCCCAGGAGGAG	0.463000													29	121					1.13719e-10	1.25892e-10	1	1	0
SGSM3	27352	broad.mit.edu	37	22	40798149	40798149	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:40798149G>C	ENST00000248929.9	+	4	286	c.97G>C	c.(97-99)Gag>Cag	p.E33Q	SGSM3_ENST00000454798.2_5'UTR	NM_015705.4	NP_056520.2	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	33					cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)	19						CTAGAAGGAAGAGTCAGCAGA	0.488000													11	49					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54581186	54581186	+	Nonsense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:54581186C>A	ENST00000251636.5	-	10	1439	c.1291G>T	c.(1291-1293)Gaa>Taa	p.E431*	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	431							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				ATGCCATCTTCTGTTAAGATT	0.398000													6	56					0.00198382	0.00203296	1	1	0
TESC	54997	broad.mit.edu	37	12	117513134	117513134	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:117513134G>A	ENST00000335209.7	-	2	256	c.70C>T	c.(70-72)Cag>Tag	p.Q24*	TESC_ENST00000392545.4_Nonsense_Mutation_p.Q77*|TESC_ENST00000541210.1_Nonsense_Mutation_p.Q24*			Q96BS2	TESC_HUMAN	tescalcin	24					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		TGCTCGATCTGATCCGATGAG	0.507000													15	66					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													4	86					0	0	1	0	0
MBD6	114785	broad.mit.edu	37	12	57918145	57918145	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:57918145C>T	ENST00000355673.3	+	3	415	c.59C>T	c.(58-60)tCt>tTt	p.S20F	MBD6_ENST00000549231.1_3'UTR|MBD6_ENST00000431731.2_Missense_Mutation_p.S20F	NM_052897.3	NP_443129.3	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	20	MBD.					chromosome|nucleus	chromatin binding|DNA binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						GTGGCCACATCTGTCCCCATC	0.592000													3	48					0	0	1	0	0
SHPK	23729	broad.mit.edu	37	17	3539490	3539490	+	Silent	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:3539490G>T	ENST00000225519.3	-	1	126	c.24C>A	c.(22-24)ctC>ctA	p.L8L		NM_013276.2	NP_037408	Q9UHJ6	SHPK_HUMAN	sedoheptulokinase	8					carbohydrate metabolic process	cytoplasm	ATP binding|sedoheptulokinase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				COAD - Colon adenocarcinoma(5;0.0828)		GGTCAATGCCGAGGGTGATCG	0.701000													6	30					0.00116845	0.00120367	1	1	0
LTB4R2	56413	broad.mit.edu	37	14	24780846	24780846	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:24780846G>C	ENST00000528054.1	+	1	2686	c.1069G>C	c.(1069-1071)Gag>Cag	p.E357Q	LTB4R2_ENST00000543919.1_Missense_Mutation_p.E326Q|LTB4R_ENST00000345363.3_5'UTR|LTB4R2_ENST00000533293.1_Missense_Mutation_p.E326Q			Q9NPC1	LT4R2_HUMAN	leukotriene B4 receptor 2	357					chemotaxis|negative regulation of adenylate cyclase activity	integral to plasma membrane				endometrium(1)|lung(1)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.018)		AGGGACCATGGAGCTCCGAAC	0.677000													18	55					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1482086	1482086	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:1482086G>A	ENST00000297508.7	-	7	1628	c.1453C>T	c.(1453-1455)Cag>Tag	p.Q485*	MICALL2_ENST00000405088.4_Nonsense_Mutation_p.Q273*	NM_182924.3	NP_891554.1	Q8IY33	MILK2_HUMAN	MICAL-like 2	485						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GTTTTGGGCTGAGAACTGGGA	0.617000													24	175					0	0	1	0	0
ABCB6	10058	broad.mit.edu	37	2	220079684	220079684	+	Splice_Site	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:220079684G>A	ENST00000265316.3	-	6	1591	c.1275C>T	c.(1273-1275)ctC>ctT	p.L425L	ABCB6_ENST00000439002.2_Splice_Site_p.L379L	NM_005689.2	NP_005680.1	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 6	425	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	34		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCACTCACTGAGGTAAAGAC	0.552000													22	33					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87035681	87035681	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:87035681G>A	ENST00000265723.4	-	26	3541	c.3430C>T	c.(3430-3432)Cgg>Tgg	p.R1144W	ABCB4_ENST00000359206.3_Missense_Mutation_p.R1137W|ABCB4_ENST00000545634.1_Missense_Mutation_p.R1137W|ABCB4_ENST00000453593.1_Missense_Mutation_p.R1090W|ABCB4_ENST00000358400.3_Missense_Mutation_p.R1090W	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	1144	ABC transporter 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GATACAACCCGGCTGTTGTCT	0.473000													9	205					0	0	1	0	0
FZD7	8324	broad.mit.edu	37	2	202899764	202899764	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:202899764G>A	ENST00000286201.1	+	1	455	c.394G>A	c.(394-396)Gag>Aag	p.E132K		NM_003507.1	NP_003498.1	O75084	FZD7_HUMAN	frizzled family receptor 7	132	FZ.				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|endometrium(6)|large_intestine(6)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	31						CCAGGGCTGCGAGGCGCTCAT	0.657000											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	44					0	0	1	0	0
STK32A	202374	broad.mit.edu	37	5	146752738	146752738	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:146752738G>A	ENST00000397936.3	+	10	1117	c.784G>A	c.(784-786)Gaa>Aaa	p.E262K	STK32A_ENST00000398523.3_Missense_Mutation_p.E262K	NM_001112724.1	NP_001106195.1	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A	262	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGCTACTCGAACCTAATCC	0.373000													29	129					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6190837	6190837	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:6190837G>A	ENST00000530810.1	-	1	801	c.720C>T	c.(718-720)ctC>ctT	p.L240L	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACAAGTGCTGAGGGCCTTGT	0.478000													15	23					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185012381	185012381	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:185012381G>C	ENST00000296741.2	-	8	1413	c.1272C>G	c.(1270-1272)gtC>gtG	p.V424V		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	424					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GGCTGGGCCAGACAGGCGGGG	0.567000													8	79					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35382429	35382429	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:35382429C>T	ENST00000378495.3	+	20	2706	c.2484C>T	c.(2482-2484)atC>atT	p.I828I	UNC13B_ENST00000396787.1_Silent_p.I840I|UNC13B_ENST00000378496.4_Silent_p.I828I	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	828					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			TGGCCAACATCAACGCCTACT	0.483000													81	85					0	0	1	0	0
C2CD5	9847	broad.mit.edu	37	12	22625729	22625729	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:22625729C>T	ENST00000333957.4	-	17	2311	c.2056G>A	c.(2056-2058)Gat>Aat	p.D686N	C2CD5_ENST00000536386.1_Missense_Mutation_p.D688N|C2CD5_ENST00000446597.1_Missense_Mutation_p.D686N|C2CD5_ENST00000545552.1_Missense_Mutation_p.D699N|C2CD5_ENST00000544930.1_Missense_Mutation_p.D501N|C2CD5_ENST00000396028.2_Missense_Mutation_p.D677N|C2CD5_ENST00000542676.1_Missense_Mutation_p.D686N	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		TCCATGGCATCTGTGTCATCA	0.289000													16	152					0	0	1	0	0
SEC24A	10802	broad.mit.edu	37	5	134002676	134002676	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:134002676C>T	ENST00000398844.2	+	3	1017	c.729C>T	c.(727-729)gtC>gtT	p.V243V	SEC24A_ENST00000322887.4_Silent_p.V243V	NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	243					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATTCAGCTGTCAACCAAGAAG	0.463000													8	34					0	0	1	0	0
C20orf166-AS1	253868	broad.mit.edu	37	20	61143549	61143549	+	RNA	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:61143549C>G	ENST00000475015.1	-	0	789				C20orf166-AS1_ENST00000412495.1_RNA																							GTGCCACATTCTGAGCACAGA	0.642000													23	31					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103574829	103574829	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:103574829C>G	ENST00000380069.3	+	10	2027	c.1951C>G	c.(1951-1953)Ctt>Gtt	p.L651V		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	651										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						CCTGGAGACTCTTATCCGGAG	0.597000													23	144					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27212749	27212749	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:27212749C>A	ENST00000380036.4	+	17	3173	c.2731C>A	c.(2731-2733)Ctg>Atg	p.L911M	TEK_ENST00000406359.4_Missense_Mutation_p.L868M|TEK_ENST00000519097.1_Missense_Mutation_p.L763M	NM_000459.3	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	911	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TGGAAACCTTCTGGACTTCCT	0.557000													4	38					0.00909568	0.00922478	1	1	0
TSHZ3	57616	broad.mit.edu	37	19	31769309	31769309	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:31769309G>T	ENST00000240587.4	-	2	1717	c.1390C>A	c.(1390-1392)Cca>Aca	p.P464T		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	464					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TTCAGTTTTGGGGAGATGCTG	0.542000													12	212					4.36969e-10	4.81033e-10	1	1	0
PPIL4	85313	broad.mit.edu	37	6	149846284	149846284	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:149846284C>G	ENST00000253329.2	-	9	897	c.865G>C	c.(865-867)Gaa>Caa	p.E289Q		NM_139126.3	NP_624311.1	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 4	289	RRM.				protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding			endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	13		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		CATACCTTTTCAAATTCAATA	0.279000													15	49					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53422316	53422316	+	Missense_Mutation	SNP	C	C	T	rs113194848		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:53422316C>T	ENST00000377942.3	-	1	459	c.256G>A	c.(256-258)Ggg>Agg	p.G86R	PCDH8_ENST00000338862.4_Missense_Mutation_p.G86R	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	86	Cadherin 1.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CCGGCGTCCCCGACGGTCAGC	0.647000													4	70					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62293299	62293299	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:62293299G>C	ENST00000378024.4	-	5	8864	c.8590C>G	c.(8590-8592)Ctg>Gtg	p.L2864V	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2864					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GGACCTTTCAGATCTCCCTCT	0.458000													48	214					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123514842	123514842	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:123514842G>A	ENST00000422452.2	-	32	7806	c.7743C>T	c.(7741-7743)taC>taT	p.Y2581Y	STAG2_ENST00000469481.1_Intron|TENM1_ENST00000371130.3_Silent_p.Y2574Y	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GCTTAATGAAGTAGTGAGTGT	0.502000													17	58					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75059366	75059366	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:75059366C>G	ENST00000401621.2	-	14	1644	c.1524G>C	c.(1522-1524)caG>caC	p.Q508H	TTC18_ENST00000394865.1_Missense_Mutation_p.Q508H|TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000310715.3_Missense_Mutation_p.Q508H|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000355577.3_5'UTR			Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	508							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					CACTTGCCTTCTGAGCTCCTC	0.388000													8	25					0	0	1	0	0
C12orf39	80763	broad.mit.edu	37	12	21680068	21680068	+	Splice_Site	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:21680068G>C	ENST00000256969.2	+	3	253		c.e3-1			NM_030572.2	NP_085049.1	Q9BT56	SPXN_HUMAN	chromosome 12 open reading frame 39							extracellular region|nucleus|transport vesicle				endometrium(3)|large_intestine(1)|lung(2)|urinary_tract(1)	7						CCGGGCTATAGAGACTGTTGG	0.418000													22	104					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940396	144940396	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:144940396C>A	ENST00000525985.1	-	2	7097	c.7026G>T	c.(7024-7026)caG>caT	p.Q2342H				P58107	EPIPL_HUMAN	epiplakin 1	2342						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCGTGGCGATCTGGGCCTCCA	0.687000													11	519					3.86212e-05	4.08014e-05	1	1	0
GPR158	57512	broad.mit.edu	37	10	25886921	25886921	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:25886921G>A	ENST00000376351.3	+	11	2725	c.2366G>A	c.(2365-2367)aGg>aAg	p.R789K	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	789						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GCCCTCATCAGGAAGAACCCC	0.547000													13	95					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18270351	18270351	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:18270351C>T	ENST00000377369.2	+	6	1308	c.1035C>T	c.(1033-1035)ctC>ctT	p.L345L	SLC39A12_ENST00000539911.1_Silent_p.L211L|SLC39A12_ENST00000377374.4_Silent_p.L345L|SLC39A12_ENST00000377371.3_Silent_p.L345L	NM_001145195.1|NM_001282733.1|NM_001282734.1	NP_001138667.1|NP_001269662.1|NP_001269663.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	345					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						AGCAGCTCCTCAGCTGCTCCT	0.502000													16	69					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64518410	64518410	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:64518410G>A	ENST00000358025.3	+	48	8009	c.7779G>A	c.(7777-7779)aaG>aaA	p.K2593K	SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Silent_p.K2593K|SYNE2_ENST00000554584.1_Silent_p.K2626K	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2593					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ACATGGATAAGAAATTGTTGG	0.353000													9	36					0	0	1	0	0
PRKAR1A	5573	broad.mit.edu	37	17	66520184	66520184	+	Silent	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:66520184C>G	ENST00000589228.1	+	5	596	c.468C>G	c.(466-468)gtC>gtG	p.V156V	PRKAR1A_ENST00000588188.2_Silent_p.V156V|PRKAR1A_ENST00000358598.2_Silent_p.V156V|PRKAR1A_ENST00000536854.2_Silent_p.V156V|PRKAR1A_ENST00000392711.1_Silent_p.V156V|PRKAR1A_ENST00000586397.1_Silent_p.V156V	NM_001276289.1|NM_001278433.1	NP_001263218.1|NP_001265362.1	P10644	KAP0_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, alpha	156					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|soft_tissue(2)|stomach(2)|testis(1)|thyroid(2)|upper_aerodigestive_tract(1)	31	Breast(10;1.64e-13)					TGTTTTCGGTCTCCTTTATCG	0.428000			"""T, Mis, N, F, S"""	RET	papillary thyroid	"""myxoma, endocrine, papillary thyroid"""			Primary Pigmented Nodular Adrenocortical Disease, Familial;Carney Complex;Cardiac Myxomas, Familial Clustering of				17	106					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48134148	48134148	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:48134148G>A	ENST00000405493.2	-	22	2345	c.2136C>T	c.(2134-2136)ttC>ttT	p.F712F	RAPGEF3_ENST00000548919.1_Intron|RAPGEF3_ENST00000171000.4_Silent_p.F712F|RAPGEF3_ENST00000549151.1_Silent_p.F712F|RP1-197B17.3_ENST00000547799.1_lincRNA|RAPGEF3_ENST00000449771.2_Silent_p.F754F|RAPGEF3_ENST00000389212.3_Silent_p.F754F	NM_001098532.2|NM_006105.5	NP_001092002|NP_006096	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	712					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		TGACGGCAAAGAAGGAATTGA	0.592000													13	50					0	0	1	0	0
UNC119B	84747	broad.mit.edu	37	12	121154517	121154517	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:121154517C>G	ENST00000344651.4	+	3	485	c.445C>G	c.(445-447)Ctc>Gtc	p.L149V		NM_001080533.1	NP_001074002.1	A6NIH7	U119B_HUMAN	unc-119 homolog B (C. elegans)	149										breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)	9	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ACCGGCATTTCTCCGCCTCCG	0.542000													24	145					0	0	1	0	0
MSRB2	22921	broad.mit.edu	37	10	23408306	23408306	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:23408306G>T	ENST00000376510.3	+	4	473	c.370G>T	c.(370-372)Gaa>Taa	p.E124*	MSRB2_ENST00000468633.1_3'UTR	NM_012228.3	NP_036360.3	Q9Y3D2	MSRB2_HUMAN	methionine sulfoxide reductase B2	124					protein repair	mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	9					L-Methionine(DB00134)	TGGCTCTGATGAAAGCCACAC	0.488000													15	93					6.72482e-11	7.46569e-11	1	1	0
ZBTB4	57659	broad.mit.edu	37	17	7365433	7365433	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:7365433C>A	ENST00000311403.4	-	4	3207	c.2868G>T	c.(2866-2868)aaG>aaT	p.K956N	ZBTB4_ENST00000380599.4_Missense_Mutation_p.K956N	NM_020899.3	NP_065950.2	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	956					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(3)|skin(6)	36		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		CCCCCGCACCCTTCTCATCAG	0.607000													30	231					3.67414e-24	4.1914e-24	1	1	0
TUBB8P7	197331	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:90162513T>C	ENST00000564451.1	+	0	1866				TUBB8P7_ENST00000567960.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													6	142					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40117221	40117221	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:40117221G>C	ENST00000373233.3	-	13	1881	c.1704C>G	c.(1702-1704)ttC>ttG	p.F568L	CHD6_ENST00000309279.7_Missense_Mutation_p.F568L	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	568	Helicase ATP-binding.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CGTGGAACTTGAAGACTCCTG	0.448000													24	76					0	0	1	0	0
DUS3L	56931	broad.mit.edu	37	19	5786498	5786498	+	Silent	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:5786498G>T	ENST00000309061.7	-	10	1638	c.1542C>A	c.(1540-1542)gtC>gtA	p.V514V	DUS3L_ENST00000320699.8_Silent_p.V272V	NM_020175.2	NP_064560.2	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like (S. cerevisiae)	514					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(2)	14						TGATCCCGGTGACACCAGTCT	0.587000													29	58					7.01153e-11	7.77301e-11	1	1	0
GOLGA1	2800	broad.mit.edu	37	9	127644215	127644215	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:127644215C>G	ENST00000373555.4	-	21	2317	c.1984G>C	c.(1984-1986)Gag>Cag	p.E662Q		NM_002077.3	NP_002068	Q92805	GOGA1_HUMAN	golgin A1	662						Golgi cisterna membrane				NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	20						TCGAAGAGCTCATTATCGGGT	0.507000													7	45					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058168	11058168	+	RNA	SNP	A	A	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr21:11058168A>T	ENST00000470054.1	-	0	479									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TACATCTTTCAGGAGCTTGGT	0.388000													4	133					0	0	1	0	0
RHOD	29984	broad.mit.edu	37	11	66837940	66837940	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:66837940C>T	ENST00000308831.2	+	4	460	c.375C>T	c.(373-375)atC>atT	p.I125I	RHOD_ENST00000532559.1_Silent_p.I59I|RHOD_ENST00000533360.1_3'UTR	NM_014578.3	NP_055393	O00212	RHOD_HUMAN	ras homolog family member D	125					regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity			lung(3)	3						TACCCATCATCGTCGTGGGCT	0.562000													17	96					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32210963	32210963	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:32210963C>T	ENST00000492345.1	+	7	1178	c.493C>T	c.(493-495)Cgg>Tgg	p.R165W	CBFA2T2_ENST00000375279.2_Missense_Mutation_p.R194W|CBFA2T2_ENST00000344201.3_Missense_Mutation_p.R165W|CBFA2T2_ENST00000397798.2_Missense_Mutation_p.R165W|CBFA2T2_ENST00000491618.1_3'UTR|CBFA2T2_ENST00000342704.6_Missense_Mutation_p.R185W|CBFA2T2_ENST00000397800.1_Missense_Mutation_p.R165W|CBFA2T2_ENST00000359606.3_Missense_Mutation_p.R204W|CBFA2T2_ENST00000346541.3_Missense_Mutation_p.R194W			O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	194	TAFH.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						GCACTGCGCTCGGGCGGCCAA	0.582000													7	68					0	0	1	0	0
CAPSL	133690	broad.mit.edu	37	5	35910599	35910599	+	Missense_Mutation	SNP	T	T	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:35910599T>C	ENST00000397367.2	-	3	310	c.184A>G	c.(184-186)Aaa>Gaa	p.K62E	CAPSL_ENST00000514524.1_Missense_Mutation_p.K62E|CAPSL_ENST00000397366.1_Missense_Mutation_p.K62E	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	62	EF-hand 1.					cytoplasm	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			ATAAATTCTTTAAAATCAAGG	0.323000													14	89					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98744091	98744091	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:98744091G>T	ENST00000286067.2	+	1	3051	c.2944G>T	c.(2944-2946)Gat>Tat	p.D982Y		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	982										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AGTCAAGGAAGATAGAAACAG	0.493000													7	83					0.000157383	0.000164499	1	1	0
LRRK2	120892	broad.mit.edu	37	12	40677743	40677743	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:40677743G>A	ENST00000298910.7	+	19	2366	c.2308G>A	c.(2308-2310)Gat>Aat	p.D770N	LRRK2_ENST00000343742.2_Missense_Mutation_p.D770N	NM_198578.3	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	770					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCGTGAACAAGATGTACGAAA	0.403000													14	91					0	0	1	0	0
SEC14L2	23541	broad.mit.edu	37	22	30812056	30812056	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:30812056C>T	ENST00000312932.9	+	10	1151	c.891C>T	c.(889-891)ctC>ctT	p.L297L	SEC14L2_ENST00000403484.1_Silent_p.L223L|SEC14L2_ENST00000402592.3_Silent_p.L214L|SEC14L2_ENST00000405717.3_Silent_p.L297L|RP4-539M6.19_ENST00000439838.1_Silent_p.L131L	NM_012429.3	NP_036561.1	O76054	S14L2_HUMAN	SEC14-like 2 (S. cerevisiae)	297	GOLD.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	phospholipid binding|transporter activity|vitamin E binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|urinary_tract(1)	10					Vitamin E(DB00163)	ATGAGATCCTCTTCCCTGGCT	0.557000													15	75					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32717355	32717355	+	Silent	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:32717355G>C	ENST00000357033.4	-	8	911	c.705C>G	c.(703-705)ctC>ctG	p.L235L	DMD_ENST00000288447.4_Silent_p.L227L|DMD_ENST00000378677.2_Silent_p.L231L	NM_000109.3|NM_004006.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	235	Actin-binding.|CH 2.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AAACTTGGAAGAGTGATGTGA	0.378000													12	35					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033362	82033362	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:82033362C>G	ENST00000328945.5	-	3	663	c.536G>C	c.(535-537)aGa>aCa	p.R179T	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	179					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						AGCGCAGGTTCTTAAGACACC	0.542000													25	161					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113686082	113686082	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:113686082G>A	ENST00000003302.4	-	14	1554	c.1486C>T	c.(1486-1488)Cag>Tag	p.Q496*	USP28_ENST00000537706.1_Nonsense_Mutation_p.Q496*|USP28_ENST00000545540.1_Nonsense_Mutation_p.Q371*|USP28_ENST00000544967.1_Nonsense_Mutation_p.Q204*|USP28_ENST00000260188.5_Nonsense_Mutation_p.Q496*	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	496					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCAACATCCTGAGAAGAGCTT	0.393000													16	31					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241705144	241705144	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:241705144G>A	ENST00000498729.2	-	20	1997	c.1751C>T	c.(1750-1752)cCc>cTc	p.P584L	KIF1A_ENST00000320389.7_Missense_Mutation_p.P575L	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	575					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CAGGATGCTGGGCTCTGTGAC	0.622000													5	15					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26692999	26692999	+	Missense_Mutation	SNP	G	G	A	rs148526431		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr22:26692999G>A	ENST00000529632.2	+	4	1311	c.1115G>A	c.(1114-1116)cGg>cAg	p.R372Q	SEZ6L_ENST00000404234.3_Missense_Mutation_p.R372Q|SEZ6L_ENST00000343706.4_Missense_Mutation_p.R372Q|SEZ6L_ENST00000402979.1_Missense_Mutation_p.R145Q|SEZ6L_ENST00000360929.3_Missense_Mutation_p.R372Q|SEZ6L_ENST00000403121.1_Missense_Mutation_p.R145Q|SEZ6L_ENST00000248933.6_Missense_Mutation_p.R372Q	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	372	CUB 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GTCTACTTCCGGACCTTCCAG	0.607000													4	28					0	0	1	0	0
WNT7A	7476	broad.mit.edu	37	3	13896086	13896086	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:13896086C>T	ENST00000285018.4	-	3	817	c.513G>A	c.(511-513)gaG>gaA	p.E171E		NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	171					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity	p.E171D(1)		NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						TCTGCTTGATCTCCCGGGCAT	0.632000													24	153					0	0	1	0	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89084343	89084343	+	RNA	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr2:89084343C>G	ENST00000393525.3	+	0	711																											ATGTCATGTTCAGCCAAGATA	0.398000													11	5					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197396999	197396999	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:197396999C>T	ENST00000367397.1	+	3	1545	c.687C>T	c.(685-687)ttC>ttT	p.F229F	CRB1_ENST00000544212.1_Silent_p.F329F|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367400.3_Silent_p.F848F|CRB1_ENST00000535699.1_Silent_p.F779F|CRB1_ENST00000367399.2_Silent_p.F736F			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	848	EGF-like 6; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						GTGGATTCTTCAAAGGCTGTA	0.383000													9	79					0	0	1	0	0
CDC40	51362	broad.mit.edu	37	6	110551168	110551168	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:110551168C>T	ENST00000368932.1	+	16	1675	c.1574C>T	c.(1573-1575)tCa>tTa	p.S525L	CDC40_ENST00000307731.1_Missense_Mutation_p.S525L|CDC40_ENST00000445340.2_Intron|CDC40_ENST00000368930.1_Intron			O60508	PRP17_HUMAN	cell division cycle 40	525					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm				breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)		TATGTGATTTCAGGAGATGGA	0.343000													9	48					0	0	1	0	0
VASP	7408	broad.mit.edu	37	19	46021215	46021215	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:46021215G>A	ENST00000245932.6	+	3	562	c.206G>A	c.(205-207)gGt>gAt	p.G69D	VASP_ENST00000586619.1_3'UTR	NM_003370.3	NP_003361.1	P50552	VASP_HUMAN	vasodilator-stimulated phosphoprotein	69	WH1.				axon guidance|cell junction assembly|T cell receptor signaling pathway	actin cytoskeleton|cytosol|filopodium membrane|focal adhesion|lamellipodium membrane	actin binding|profilin binding|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(2)	18		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0145)|GBM - Glioblastoma multiforme(486;0.154)		ATCGTCCGGGGTGTCAAGTAT	0.662000													8	28					0	0	1	0	0
USP15	9958	broad.mit.edu	37	12	62795014	62795014	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:62795014G>C	ENST00000280377.5	+	21	2780	c.2722G>C	c.(2722-2724)Gat>Cat	p.D908H	USP15_ENST00000393654.3_Missense_Mutation_p.D883H|USP15_ENST00000353364.3_Missense_Mutation_p.D879H	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	908					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		GTACTATTTTGATGACAGTAG	0.338000													10	33					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96508441	96508441	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:96508441C>A	ENST00000376747.3	-	34	4049	c.3979G>T	c.(3979-3981)Gac>Tac	p.D1327Y		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	1327	Glucosyltransferase.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						ATGATTTTGTCCACTGCTAGT	0.348000													19	70					2.94398e-08	3.20939e-08	1	1	0
MMP14	4323	broad.mit.edu	37	14	23313059	23313059	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:23313059G>T	ENST00000311852.6	+	6	1252	c.991G>T	c.(991-993)Ggg>Tgg	p.G331W	MMP14_ENST00000548162.1_3'UTR	NM_004995.2	NP_004986.1	P50281	MMP14_HUMAN	matrix metallopeptidase 14 (membrane-inserted)	331	Hemopexin-like 1.					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		CATGCTCCGAGGGGAGATGTT	0.542000													9	84					1.33987e-11	1.49381e-11	1	1	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													4	14					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130312094	130312094	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr3:130312094C>T	ENST00000358511.6	+	16	4499	c.4468C>T	c.(4468-4470)Cag>Tag	p.Q1490*	COL6A6_ENST00000453409.2_Nonsense_Mutation_p.Q1490*	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1490	Triple-helical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TGAGGGATCTCAGGTAGGGAT	0.363000													5	30					0	0	1	0	0
HENMT1	113802	broad.mit.edu	37	1	109193814	109193814	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:109193814G>A	ENST00000370032.5	-	6	836	c.416C>T	c.(415-417)tCa>tTa	p.S139L	HENMT1_ENST00000493676.1_5'UTR|HENMT1_ENST00000402983.1_Missense_Mutation_p.S139L|HENMT1_ENST00000370031.1_Missense_Mutation_p.S139L	NM_144584.2	NP_653185.2	Q5T8I9	HENMT_HUMAN	HEN1 methyltransferase homolog 1 (Arabidopsis)	139					gene silencing by RNA|piRNA metabolic process	P granule	metal ion binding|O-methyltransferase activity|RNA binding|RNA methyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|stomach(1)	16						CAGATCACCTGAATCCAAATG	0.358000													7	37					0	0	1	0	0
BPIFB6	128859	broad.mit.edu	37	20	31625463	31625463	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr20:31625463G>A	ENST00000349552.1	+	8	765	c.765G>A	c.(763-765)caG>caA	p.Q255Q		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	255						extracellular region	lipid binding										GCTCGTCGCAGCTGCTGCTCC	0.562000													12	106					0	0	1	0	0
HERC3	8916	broad.mit.edu	37	4	89625430	89625430	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:89625430G>C	ENST00000402738.1	+	24	3078	c.2839G>C	c.(2839-2841)Gag>Cag	p.E947Q	HERC3_ENST00000264345.3_Missense_Mutation_p.E947Q|HERC3_ENST00000543130.1_Missense_Mutation_p.E391Q	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	947					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		AGAACTGGAAGAGGTAAGCAC	0.517000													10	73					0	0	1	0	0
MAP3K14	9020	broad.mit.edu	37	17	43363963	43363963	+	RNA	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:43363963C>T	ENST00000344686.2	-	0	1092							Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CAGAAAACTTCTCATGGGCAC	0.612000													4	26					0	0	1	0	0
CBX4	8535	broad.mit.edu	37	17	77808877	77808877	+	Silent	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:77808877C>A	ENST00000269397.4	-	5	741	c.564G>T	c.(562-564)ctG>ctT	p.L188L	CBX4_ENST00000448310.1_3'UTR	NM_003655.2	NP_003646.2	O00257	CBX4_HUMAN	chromobox homolog 4	188	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TCTTGGCCCCCAGGTCCGGGC	0.706000											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	55					4.36969e-10	4.81033e-10	1	1	0
ZNF547	284306	broad.mit.edu	37	19	57889199	57889199	+	Missense_Mutation	SNP	G	G	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:57889199G>T	ENST00000282282.3	+	4	1005	c.855G>T	c.(853-855)agG>agT	p.R285S	AC003002.4_ENST00000597658.1_Intron	NM_173631.2	NP_775902.2	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACCTCTTTAGGCATTACAGAA	0.413000													20	109					2.27731e-05	2.41887e-05	1	1	0
TMEM97	27346	broad.mit.edu	37	17	26652669	26652669	+	Silent	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:26652669C>T	ENST00000226230.6	+	2	412	c.267C>T	c.(265-267)ctC>ctT	p.L89L	TMEM97_ENST00000583381.1_5'UTR|TMEM97_ENST00000582113.1_Silent_p.L89L|TMEM97_ENST00000336687.6_5'UTR	NM_014573.2	NP_055388.2	Q5BJF2	TMM97_HUMAN	transmembrane protein 97	89					cholesterol homeostasis|regulation of cell growth	integral to membrane|lysosome|nuclear membrane|plasma membrane|rough endoplasmic reticulum	protein binding			endometrium(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	6	all_lung(13;0.000238)|Lung NSC(42;0.000789)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		ATGCCTTCCTCAAAGGTTGGT	0.473000													20	142					0	0	1	0	0
CLCN3	1182	broad.mit.edu	37	4	170608844	170608844	+	Missense_Mutation	SNP	G	G	C			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr4:170608844G>C	ENST00000513761.1	+	4	913	c.354G>C	c.(352-354)atG>atC	p.M118I	CLCN3_ENST00000504131.2_Missense_Mutation_p.M101I|CLCN3_ENST00000360642.3_Missense_Mutation_p.M118I|CLCN3_ENST00000347613.4_Missense_Mutation_p.M118I	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	118					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		CATGGGAAATGACAAAAAGTT	0.338000													6	50					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48132488	48132488	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:48132488G>A	ENST00000405493.2	-	25	2594	c.2385C>T	c.(2383-2385)atC>atT	p.I795I	RAPGEF3_ENST00000548919.1_Silent_p.I728I|RAPGEF3_ENST00000171000.4_Silent_p.I795I|RAPGEF3_ENST00000549151.1_Silent_p.I795I|RP1-197B17.3_ENST00000547799.1_lincRNA|RAPGEF3_ENST00000449771.2_Silent_p.I837I|RAPGEF3_ENST00000389212.3_Silent_p.I837I	NM_001098532.2|NM_006105.5	NP_001092002|NP_006096	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	795					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		TCTCAAAGTTGATGAGATTCT	0.502000													16	111					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	22078694	22078694	+	Missense_Mutation	SNP	A	A	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr5:22078694A>G	ENST00000382254.1	-	5	1178	c.92T>C	c.(91-93)tTa>tCa	p.L31S	CDH12_ENST00000522262.1_Missense_Mutation_p.L31S|CDH12_ENST00000504376.2_Missense_Mutation_p.L31S	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	31					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						CTCTGTGGCTAAAGTCTGCTG	0.463000										HNSCC(59;0.17)			81	132					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14737434	14737434	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr9:14737434C>G	ENST00000380881.4	-	38	7318	c.6503G>C	c.(6502-6504)aGa>aCa	p.R2168T	FREM1_ENST00000422223.2_Missense_Mutation_p.R2167T|FREM1_ENST00000380894.1_Missense_Mutation_p.R703T|FREM1_ENST00000380880.3_Missense_Mutation_p.R2167T			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	2167	C-type lectin.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGGTTTGGCTCTCCTACAGTC	0.448000													23	20					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61765757	61765757	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:61765757C>T	ENST00000423902.2	+	31	6952	c.6473C>T	c.(6472-6474)tCa>tTa	p.S2158L	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2158					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CCAGTCATCTCATCTGCTCAT	0.473000													14	24					0	0	1	0	0
PLEKHJ1	55111	broad.mit.edu	37	19	2234155	2234155	+	Missense_Mutation	SNP	C	C	T	rs143901250	by1000genomes	TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr19:2234155C>T	ENST00000589097.1	-	5	1427	c.314G>A	c.(313-315)cGg>cAg	p.R105Q	PLEKHJ1_ENST00000591099.2_Intron|PLEKHJ1_ENST00000589791.1_5'UTR|PLEKHJ1_ENST00000587962.2_Missense_Mutation_p.R105Q|PLEKHJ1_ENST00000586608.2_Intron|PLEKHJ1_ENST00000587394.2_Missense_Mutation_p.R105Q|PLEKHJ1_ENST00000326631.2_Missense_Mutation_p.R105Q			Q9NW61	PKHJ1_HUMAN	pleckstrin homology domain containing, family J member 1	105	PH.						protein binding			endometrium(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCTGGCCCGACGCAGAGC	0.632000													9	63					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46871573	46871573	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:46871573C>T	ENST00000433608.2	-	1	123	c.70G>A	c.(70-72)Gaa>Aaa	p.E24K	TTLL6_ENST00000393382.3_Intron	NM_173623.3	NP_775894.2	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	0						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						CACCTTAGTTCTGCTACCCCG	0.537000													5	45					0	0	1	0	0
TCEAL3	85012	broad.mit.edu	37	X	102864368	102864368	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:102864368C>T	ENST00000372628.1	+	3	734	c.376C>T	c.(376-378)Cag>Tag	p.Q126*	TCEAL3_ENST00000243286.3_Nonsense_Mutation_p.Q126*|TCEAL3_ENST00000477014.1_Intron|TCEAL3_ENST00000372627.5_Nonsense_Mutation_p.Q126*			Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.Q126K(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	16						CAAGGACTCTCAGGAGGACTT	0.532000													21	93					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110830423	110830423	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:110830423G>A	ENST00000375820.4	-	32	2735	c.2614C>T	c.(2614-2616)Cct>Tct	p.P872S		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	872	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGAAACCCAGGAATCCCAGGA	0.537000													10	90					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147380410	147380410	+	Missense_Mutation	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:147380410G>A	ENST00000240986.4	+	2	381	c.328G>A	c.(328-330)Gag>Aag	p.E110K	GJA8_ENST00000369235.1_Missense_Mutation_p.E110K	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	110				EA -> D (in Ref. 1; AAA77062).	cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					CAAAAGCCGCGAGGCGGAGGA	0.652000													35	79					0	0	1	0	0
TRAV20	28663	broad.mit.edu	37	14	22508855	22508855	+	RNA	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:22508855C>G	ENST00000390448.3	+	0	16																											AGTGGCGCCTCTGAGAAAAGA	0.408000													7	38					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102437	22102437	+	Missense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr14:22102437C>G	ENST00000542433.1	-	1	659	c.562G>C	c.(562-564)Gca>Cca	p.A188P		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	188					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		CTCAATACTGCGCGGATGTCA	0.547000													38	108					0	0	1	0	0
AGAP10	728127	broad.mit.edu	37	10	47207828	47207828	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:47207828C>A	ENST00000355232.3	-	5	3467	c.455G>T	c.(454-456)aGc>aTc	p.S152I	AGAP10_ENST00000413193.2_Missense_Mutation_p.S223I|AGAP10_ENST00000452145.2_Missense_Mutation_p.S127I|RP11-144G6.12_ENST00000605970.1_RNA					ArfGAP with GTPase domain, ankyrin repeat and PH domain 10									p.S223I(4)		endometrium(5)|kidney(3)|lung(1)|prostate(2)|urinary_tract(1)	12						TGTACAGTTGCTTCTTCTTAT	0.264000													3	25					0.004672	0.00475673	1	1	0
LYZL2	119180	broad.mit.edu	37	10	30901759	30901759	+	Missense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr10:30901759C>T	ENST00000375318.2	-	4	563	c.507G>A	c.(505-507)atG>atA	p.M169I		NM_183058.2	NP_898881.2	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	123					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			NS(2)|central_nervous_system(1)|large_intestine(1)|lung(14)|prostate(1)	19		Prostate(175;0.151)				ACCAATAGTTCATTCCTTGTG	0.423000													23	69					0	0	1	0	0
GFOD2	81577	broad.mit.edu	37	16	67709544	67709544	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr16:67709544G>A	ENST00000268797.7	-	3	1017	c.672C>T	c.(670-672)ttC>ttT	p.F224F	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	224						proteinaceous extracellular matrix	binding|oxidoreductase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		GCATCTGGAAGAAACAGAAGT	0.572000													7	61					0	0	1	0	0
CSF2RA	1438	broad.mit.edu	37	X	1409271	1409271	+	Nonsense_Mutation	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chrX:1409271C>G	ENST00000381524.3	+	7	701	c.515C>G	c.(514-516)tCa>tGa	p.S172*	CSF2RA_ENST00000355432.3_Nonsense_Mutation_p.S172*|CSF2RA_ENST00000501036.2_Nonsense_Mutation_p.S39*|CSF2RA_ENST00000494969.2_Intron|CSF2RA_ENST00000381500.1_Nonsense_Mutation_p.S172*|CSF2RA_ENST00000355805.2_Nonsense_Mutation_p.S172*|CSF2RA_ENST00000417535.2_Nonsense_Mutation_p.S172*|CSF2RA_ENST00000361536.3_Nonsense_Mutation_p.S172*|CSF2RA_ENST00000381529.3_Nonsense_Mutation_p.S172*|CSF2RA_ENST00000432318.2_Nonsense_Mutation_p.S172*|CSF2RA_ENST00000381509.3_Nonsense_Mutation_p.S172*			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	172						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ATACAAGACTCAGGAACCCAT	0.433000													72	168					0	0	1	0	0
OVCH2	341277	broad.mit.edu	37	11	7723844	7723844	+	RNA	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr11:7723844C>T	ENST00000454689.1	-	0	322				OVCH2_ENST00000534193.2_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		GTCATACTCTCCAGCAGTAAC	0.393000													5	7					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27087458	27087458	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:27087458C>T	ENST00000324856.7	+	5	2403	c.2032C>T	c.(2032-2034)Cag>Tag	p.Q678*	ARID1A_ENST00000374152.2_Nonsense_Mutation_p.Q295*|ARID1A_ENST00000457599.2_Nonsense_Mutation_p.Q678*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	678					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.N675fs*64(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TAATCCAGCTCAGTCTCCTTT	0.582000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								12	64					0	0	1	0	0
SFRP1	6422	broad.mit.edu	37	8	41122824	41122824	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr8:41122824G>A	ENST00000220772.3	-	3	1144	c.807C>T	c.(805-807)ctC>ctT	p.L269L	SFRP1_ENST00000379845.3_Silent_p.L133L	NM_003012.4	NP_003003.3	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	269	NTR.				brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			GGCCCATGATGAGGAAGTGGT	0.502000													13	90					0	0	1	0	0
ZNF670	93474	broad.mit.edu	37	1	247202111	247202111	+	Splice_Site	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:247202111C>G	ENST00000366503.2	-	3	350		c.e3+1			NM_001204220.1|NM_033213.4	NP_001191149.1|NP_149990.1	Q9BS34	ZN670_HUMAN	zinc finger protein 670						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			ATGCAAATTACCTTAGATTTC	0.323000													19	51					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51834543	51834543	+	Silent	SNP	G	G	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr15:51834543G>A	ENST00000251076.5	-	9	1379	c.1092C>T	c.(1090-1092)atC>atT	p.I364I	DMXL2_ENST00000543779.2_Silent_p.I364I|DMXL2_ENST00000449909.3_Silent_p.I364I	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	364						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		TGGCAGGGTTGATGCTTGCTG	0.368000													11	79					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13731886	13731886	+	Missense_Mutation	SNP	C	C	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr18:13731886C>A	ENST00000383314.2	+	3	610	c.370C>A	c.(370-372)Caa>Aaa	p.Q124K	RNMT_ENST00000589866.1_Missense_Mutation_p.Q124K|RNMT_ENST00000543302.2_Missense_Mutation_p.Q124K|RNMT_ENST00000262173.3_Missense_Mutation_p.Q124K|RNMT_ENST00000592764.1_Missense_Mutation_p.Q124K|RNMT_ENST00000535051.1_Intron			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	124					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						AGATGGCACTCAAAATAAGAG	0.323000													14	60					6.31663e-08	6.85755e-08	1	1	0
HECTD4	283450	broad.mit.edu	37	12	112610476	112610476	+	Splice_Site	SNP	C	C	G			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:112610476C>G	ENST00000550722.1	-	67	11741	c.11346G>C	c.(11344-11346)ctG>ctC	p.L3782L	HECTD4_ENST00000430131.2_Splice_Site_p.L3506L|HECTD4_ENST00000377560.5_Splice_Site_p.L3756L	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GCCACATACTCAGGAGACAGG	0.617000													13	34					0	0	1	0	0
DYRK3	8444	broad.mit.edu	37	1	206811015	206811016	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr1:206811015_206811016delAC	ENST00000367106.1	+	3	511_512	c.38_39delAC	c.(37-39)gacfs	p.D13fs	DYRK3_ENST00000367109.2_Frame_Shift_Del_p.D33fs|DYRK3_ENST00000489878.1_3'UTR|DYRK3_ENST00000367108.3_Frame_Shift_Del_p.D13fs			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	33					erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			GGTGTCTATGACACCTTCATGA	0.396													17	77	---	---	---	---					
SYNGAP1	8831	broad.mit.edu	37	6	33414463	33414463	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr6:33414463delA	ENST00000418600.2	+	17	3795	c.3694delA	c.(3694-3696)aaafs	p.K1232fs	SYNGAP1_ENST00000496374.1_3'UTR|SYNGAP1_ENST00000293748.5_Frame_Shift_Del_p.K1232fs|SYNGAP1_ENST00000428982.2_Frame_Shift_Del_p.K1173fs	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	1232					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						ACAAACCAGCAAAATCCTGAT	0.542													19	19	---	---	---	---					
ADCYAP1R1	117	broad.mit.edu	37	7	31104542	31104542	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:31104542delT	ENST00000304166.4	+	3	436	c.147delT	c.(145-147)gatfs	p.D49fs	ADCYAP1R1_ENST00000409489.1_Frame_Shift_Del_p.D49fs|ADCYAP1R1_ENST00000409363.1_Frame_Shift_Del_p.D49fs|ADCYAP1R1_ENST00000396211.2_Frame_Shift_Del_p.D49fs	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	49					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						GCTTCAATGATTCCTCTCCAG	0.567													8	18	---	---	---	---					
TRBV29-1	28558	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													6	13	---	---	---	---					
RP11-478C19.2	0	broad.mit.edu	37	12	110868215	110868216	+	RNA	DEL	GT	GT	-	rs113592903		TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr12:110868215_110868216delGT	ENST00000550231.1	-	0	97																											CAgtgtgtgcgtgtgtgtgtgt	0.490													3	6	---	---	---	---					
FBXL3	26224	broad.mit.edu	37	13	77581683	77581683	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr13:77581683delA	ENST00000355619.5	-	5	1208	c.884delT	c.(883-885)ttafs	p.L295fs	FBXL3_ENST00000477982.1_Intron	NM_012158.2	NP_036290.1	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	295					regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity	p.L295fs*3(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|urinary_tract(1)	16		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)		TTCTTCATATAAAAAAAAATA	0.418													8	90	---	---	---	---					
DDX52	11056	broad.mit.edu	37	17	36002277	36002278	+	Frame_Shift_Ins	INS	-	-	A			TCGA-2F-A9KO-01A-11D-A38G-08	TCGA-2F-A9KO-11A-12D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	264520a6-75e4-4059-8151-8fd7eb8d3f34	1efdb2f8-6199-4a84-b815-44111b99465e	g.chr17:36002277_36002278insA	ENST00000349699.2	-	2	190_191	c.147_148insT	c.(145-150)tttggafs	p.G50fs	DDX52_ENST00000394367.3_5'UTR	NM_007010.3	NP_008941.2	Q9Y2R4	DDX52_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 52	50						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			biliary_tract(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|ovary(1)|skin(3)	17		Breast(25;0.00637)|Ovarian(249;0.15)				TTCTTGTTTCCAAAAAAGTCCA	0.401													29	73	---	---	---	---					
