Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHST9	83539	broad.mit.edu	37	18	24497142	24497142	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr18:24497142C>G	ENST00000284224.8	-	6	690	c.413G>C	c.(412-414)gGa>gCa	p.G138A	CHST9_ENST00000580774.1_3'UTR|AQP4-AS1_ENST00000578701.1_RNA|AQP4-AS1_ENST00000579964.1_RNA|AQP4-AS1_ENST00000582605.1_RNA|AQP4-AS1_ENST00000568797.1_RNA|CHST9_ENST00000581714.1_Missense_Mutation_p.G138A	NM_031422.5	NP_113610.2	Q7L1S5	CHST9_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9	138					carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|skin(3)	28	all_lung(6;0.0145)|Ovarian(20;0.124)					AGTCTTAGCTCCTTGACGTTT	0.383000													36	168					0	0	1	0	0
KLK1	3816	broad.mit.edu	37	19	51323215	51323215	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr19:51323215C>T	ENST00000448701.2	-	5	1591	c.267G>A	c.(265-267)caG>caA	p.Q89Q	KLK1_ENST00000301420.2_Silent_p.Q191Q			P06870	KLK1_HUMAN	kallikrein 1	191	Peptidase S1.				proteolysis	nucleus	serine-type endopeptidase activity			breast(1)|large_intestine(4)|lung(7)|urinary_tract(1)	13		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGTCACCTTCTGGACGTGGG	0.552000													6	34					0	0	1	0	0
ZZZ3	26009	broad.mit.edu	37	1	78097617	78097617	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:78097617G>C	ENST00000370801.3	-	5	1898	c.1423C>G	c.(1423-1425)Cag>Gag	p.Q475E	ZZZ3_ENST00000476275.1_5'UTR|ZZZ3_ENST00000370798.1_Intron	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	475					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						GTAATGTGCTGACTGGCACTC	0.393000													33	82					0	0	1	0	0
PPP4C	5531	broad.mit.edu	37	16	30096296	30096296	+	Silent	SNP	C	C	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr16:30096296C>A	ENST00000279387.7	+	9	1005	c.837C>A	c.(835-837)ctC>ctA	p.L279L	PPP4C_ENST00000561610.1_Silent_p.L279L	NM_002720.1	NP_002711.1	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	279					microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|lung(2)|pancreas(1)|skin(1)|urinary_tract(1)	9						ACGAGCATCTCCAGAAAGATT	0.632000													20	64					8.28177e-16	8.8076e-16	1	1	0
BCR	613	broad.mit.edu	37	22	23603181	23603181	+	Silent	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr22:23603181C>G	ENST00000305877.8	+	3	2257	c.1506C>G	c.(1504-1506)gtC>gtG	p.V502V	BCR_ENST00000359540.3_Silent_p.V502V	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	502	DH.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						GAAAATGGGTCCTGTCGGGAA	0.567000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								3	55					0	0	1	0	0
SNRNP48	154007	broad.mit.edu	37	6	7601709	7601709	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr6:7601709G>A	ENST00000342415.5	+	5	606	c.547G>A	c.(547-549)Gaa>Aaa	p.E183K		NM_152551.3	NP_689764.3	Q6IEG0	SNR48_HUMAN	small nuclear ribonucleoprotein 48kDa (U11/U12)	183					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding			kidney(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	10						TCAAATTATTGAAAATGACAG	0.368000													10	84					0	0	1	0	0
KDELR2	11014	broad.mit.edu	37	7	6509247	6509247	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr7:6509247G>A	ENST00000258739.4	-	3	515	c.331C>T	c.(331-333)Cac>Tac	p.H111Y	KDELR2_ENST00000490996.1_Missense_Mutation_p.H111Y|DAGLB_ENST00000436575.1_Intron|KDELR2_ENST00000463747.1_Intron	NM_006854.3	NP_006845.1	P33947	ERD22_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	111					intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	KDEL sequence binding|protein binding|receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	10		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		GAGAAATCGTGATTAACTAAA	0.478000													38	47					0	0	1	0	0
DUOXA1	90527	broad.mit.edu	37	15	45412485	45412485	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr15:45412485C>T	ENST00000558996.1	-	5	507	c.453G>A	c.(451-453)gtG>gtA	p.V151V	DUOXA1_ENST00000560572.1_Silent_p.V196V|DUOXA1_ENST00000430224.2_Silent_p.V151V|DUOXA1_ENST00000558422.1_Silent_p.V151V|DUOXA1_ENST00000559014.1_Silent_p.V196V|DUOXA1_ENST00000267803.4_Silent_p.V196V	NM_001276267.1|NM_001276268.1	NP_001263196.1|NP_001263197.1	Q1HG43	DOXA1_HUMAN	dual oxidase maturation factor 1	196					protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		TGGAGAGCATCACATTGGCCA	0.572000													17	78					0	0	1	0	0
ACPP	55	broad.mit.edu	37	3	132071612	132071612	+	Missense_Mutation	SNP	G	G	A	rs140885758		TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr3:132071612G>A	ENST00000336375.5	+	9	1003	c.913G>A	c.(913-915)Gga>Aga	p.G305R	ACPP_ENST00000475741.1_Missense_Mutation_p.G272R|ACPP_ENST00000351273.7_Missense_Mutation_p.G305R	NM_001099.4	NP_001090.2	P15309	PPAP_HUMAN	acid phosphatase, prostate	305						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(5)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	27						TGTTTACAACGGACTCCTTCC	0.433000													33	32					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98528335	98528335	+	Missense_Mutation	SNP	T	T	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr7:98528335T>G	ENST00000359863.4	+	25	3682	c.3473T>G	c.(3472-3474)cTg>cGg	p.L1158R	TRRAP_ENST00000355540.3_Missense_Mutation_p.L1158R|TRRAP_ENST00000446306.3_Missense_Mutation_p.L1157R	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1158					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TATGCAAAGCTGGGGGGTGTG	0.507000													66	104					0	0	1	0	0
TRIM60	166655	broad.mit.edu	37	4	165961669	165961669	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr4:165961669G>C	ENST00000512596.1	+	3	661	c.445G>C	c.(445-447)Gag>Cag	p.E149Q	TRIM60_ENST00000508504.1_Missense_Mutation_p.E149Q|TRIM60_ENST00000341062.5_Missense_Mutation_p.E149Q	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	149						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		AGGTAGCCTTGAGCCCTTGAG	0.398000													3	51					0	0	1	0	0
CPD	1362	broad.mit.edu	37	17	28754486	28754486	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:28754486C>T	ENST00000225719.4	+	7	2003	c.1927C>T	c.(1927-1929)Cag>Tag	p.Q643*	CPD_ENST00000543464.2_Nonsense_Mutation_p.Q396*	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	643	Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						CCAGTTTGTTCAGATCACAGA	0.403000													10	83					0	0	1	0	0
IGLV1-36	28826	broad.mit.edu	37	22	22786533	22786533	+	RNA	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr22:22786533C>T	ENST00000390301.2	+	0	123																											CAGCCACCCTCGGTGTCTGAA	0.542000											OREG0026362	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	73					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	39					0	0	1	0	0
TTC31	64427	broad.mit.edu	37	2	74717816	74717816	+	Nonsense_Mutation	SNP	G	G	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr2:74717816G>T	ENST00000410003.1	+	5	505	c.496G>T	c.(496-498)Gag>Tag	p.E166*	TTC31_ENST00000442235.2_Nonsense_Mutation_p.E22*|TTC31_ENST00000463189.1_3'UTR|TTC31_ENST00000233623.5_Nonsense_Mutation_p.E166*			Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	166							binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9						GCTGGTGGCTGAGGAGGAGCG	0.537000													3	14					0.00909568	0.00923349	1	1	0
GPR179	440435	broad.mit.edu	37	17	36485968	36485968	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:36485968T>A	ENST00000342292.4	-	11	3504	c.3484A>T	c.(3484-3486)Agc>Tgc	p.S1162C		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	1162						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AGCATCCTGCTGGTGTGAGCG	0.602000													62	77					0	0	1	0	0
ACADVL	37	broad.mit.edu	37	17	7126021	7126021	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:7126021C>G	ENST00000356839.5	+	10	1093	c.914C>G	c.(913-915)tCa>tGa	p.S305*	ACADVL_ENST00000350303.5_Nonsense_Mutation_p.S283*|ACADVL_ENST00000543245.2_Nonsense_Mutation_p.S328*	NM_000018.3|NM_001270448.1	NP_000009.1|NP_001257377.1	P49748	ACADV_HUMAN	acyl-CoA dehydrogenase, very long chain	305	Catalytic.				energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(1)|ovary(4)|skin(1)	21						ATCAAGGCTTCAAACACAGCA	0.547000													3	23					0	0	1	0	0
MIEN1	84299	broad.mit.edu	37	17	37885839	37885839	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:37885839C>G	ENST00000394231.3	-	4	575	c.284G>C	c.(283-285)aGa>aCa	p.R95T	MIEN1_ENST00000474210.1_5'UTR|ERBB2_ENST00000584888.1_Intron|MIEN1_ENST00000577810.1_3'UTR			Q9BRT3	CQ037_HUMAN	migration and invasion enhancer 1	95					cell redox homeostasis	cytosol|membrane	selenium binding										ATTACTGGCTCTTCGGATGGC	0.532000													18	94					0	0	1	0	0
MSRB3	253827	broad.mit.edu	37	12	65857056	65857056	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:65857056G>A	ENST00000308259.5	+	7	786	c.512G>A	c.(511-513)gGc>gAc	p.G171D	MSRB3_ENST00000355192.3_Missense_Mutation_p.G178D|MSRB3_ENST00000535664.1_Missense_Mutation_p.G171D	NM_001031679.2|NM_001193460.1	NP_001026849.1|NP_001180389.1	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3	178					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		GCCGAGGGAGGCAGTGGGGTC	0.502000													13	63					0	0	1	0	0
FBXL17	64839	broad.mit.edu	37	5	107521822	107521822	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr5:107521822C>G	ENST00000542267.1	-	6	2147	c.1741G>C	c.(1741-1743)Gac>Cac	p.D581H	FBXL17_ENST00000496714.1_Missense_Mutation_p.D183H|FBXL17_ENST00000359660.5_Missense_Mutation_p.D183H	NM_001163315.2	NP_001156787.2	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	581										endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		GGTTACCTGTCATTTATGATC	0.313000													16	50					0	0	1	0	0
DNAJB5	25822	broad.mit.edu	37	9	34993317	34993317	+	Silent	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr9:34993317G>A	ENST00000541010.1	+	1	3099	c.87G>A	c.(85-87)ttG>ttA	p.L29L	DNAJB5_ENST00000335998.3_Silent_p.L63L|DNAJB5_ENST00000453597.3_Silent_p.L143L|DNAJB5_ENST00000454002.2_Silent_p.L101L|DNAJB5_ENST00000312316.5_Silent_p.L29L|DNAJB5_ENST00000545841.1_Silent_p.L29L			O75953	DNJB5_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 5	29	J.				protein folding|response to unfolded protein		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(32;0.00575)			AGATGGCCTTGAAGTACCACC	0.498000													19	88					0	0	1	0	0
C1orf158	93190	broad.mit.edu	37	1	12819368	12819368	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:12819368G>A	ENST00000288048.5	+	3	567	c.351G>A	c.(349-351)tgG>tgA	p.W117*	C1orf158_ENST00000376210.3_Nonsense_Mutation_p.W79*	NM_152290.2	NP_689503.2	Q8N1D5	CA158_HUMAN	chromosome 1 open reading frame 158	117										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|ovary(1)|skin(2)|urinary_tract(3)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TCCGCACTTGGAATGGACAGA	0.537000													39	44					0	0	1	0	0
F10	2159	broad.mit.edu	37	13	113803524	113803524	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr13:113803524G>A	ENST00000375559.3	+	8	1198	c.1160G>A	c.(1159-1161)cGc>cAc	p.R387H	F10_ENST00000409306.1_3'UTR|F10_ENST00000375551.3_3'UTR	NM_000504.3	NP_000495.1	P00742	FA10_HUMAN	coagulation factor X	387	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity	p.R387H(1)		endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	TACGTGGACCGCAACAGCTGC	0.627000													3	42					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	123987647	123987647	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr3:123987647G>A	ENST00000360013.3	+	5	635	c.508G>A	c.(508-510)Gag>Aag	p.E170K	KALRN_ENST00000460856.1_Missense_Mutation_p.E170K|KALRN_ENST00000240874.3_Missense_Mutation_p.E170K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	170	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CCAGCTGACGGAGGAGTTTGA	0.587000													3	32					0	0	1	0	0
EIF3D	8664	broad.mit.edu	37	22	36920720	36920720	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr22:36920720C>T	ENST00000216190.8	-	4	599	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K	EIF3D_ENST00000541106.1_Intron|EIF3D_ENST00000405442.1_Missense_Mutation_p.E77K	NM_003753.3	NP_003744.1	O15371	EIF3D_HUMAN	eukaryotic translation initiation factor 3, subunit D	77						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			cervix(1)|endometrium(2)|large_intestine(6)|lung(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	15						AAGCTACTTTCATCCTCCTCA	0.512000													19	153					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28814607	28814607	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr2:28814607C>T	ENST00000422425.2	+	30	2179	c.2135C>T	c.(2134-2136)tCt>tTt	p.S712F	PLB1_ENST00000329020.6_Missense_Mutation_p.S411F|PLB1_ENST00000327757.5_Missense_Mutation_p.S723F	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	723	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					AGAGCCCCTTCTGCCTTGCAC	0.577000													14	65					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100687057	100687057	+	Silent	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr7:100687057G>A	ENST00000306151.4	+	3	12424	c.12360G>A	c.(12358-12360)aaG>aaA	p.K4120K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4120						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CTACAATTAAGAGCAACCCCA	0.463000													10	61					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	242007233	242007233	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr2:242007233C>A	ENST00000310397.8	+	22	3065	c.3065C>A	c.(3064-3066)tCa>tAa	p.S1022*	SNED1_ENST00000342631.6_Nonsense_Mutation_p.S1022*|SNED1_ENST00000405547.3_Nonsense_Mutation_p.S1022*|SNED1_ENST00000401884.1_Nonsense_Mutation_p.S1022*	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	1022	Fibronectin type-III 2.				cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		AGCACCATCTCAGTGCAGTGG	0.657000													7	25					2.0095e-06	2.09279e-06	1	1	0
MYH10	4628	broad.mit.edu	37	17	8404169	8404169	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:8404169G>A	ENST00000360416.3	-	29	3857	c.3719C>T	c.(3718-3720)tCa>tTa	p.S1240L	MYH10_ENST00000379980.4_Missense_Mutation_p.S1225L|MYH10_ENST00000396239.1_Missense_Mutation_p.S1230L|MYH10_ENST00000269243.4_Missense_Mutation_p.S1209L	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	1209					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CAGCTGCTCTGAGAGCTCCTC	0.562000													46	74					0	0	1	0	0
GRB7	2886	broad.mit.edu	37	17	37901234	37901234	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:37901234C>T	ENST00000309156.4	+	9	1265	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F	GRB7_ENST00000394211.3_Silent_p.F336F|GRB7_ENST00000394204.1_Silent_p.F336F|GRB7_ENST00000309185.3_Silent_p.F336F|GRB7_ENST00000445327.2_Silent_p.F359F|GRB7_ENST00000394209.2_Silent_p.F336F	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	336	PH.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCCGCCTCTTCAAGGTGAGAC	0.617000													4	11					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79733375	79733375	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr5:79733375G>C	ENST00000338008.5	+	3	1051	c.871G>C	c.(871-873)Gaa>Caa	p.E291Q	ZFYVE16_ENST00000505560.1_Missense_Mutation_p.E291Q|ZFYVE16_ENST00000510158.1_Missense_Mutation_p.E291Q	NM_001284236.1|NM_014733.3	NP_001271165.1|NP_055548	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	291					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		AACTGCCGCAGAATGTTTAAA	0.388000													16	55					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103629704	103629704	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr7:103629704A>G	ENST00000424685.2	-	1	259	c.100T>C	c.(100-102)Tcg>Ccg	p.S34P	RELN_ENST00000343529.5_Missense_Mutation_p.S34P|RELN_ENST00000428762.1_Missense_Mutation_p.S34P			P78509	RELN_HUMAN	reelin	34	Reelin.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AAGAAGGGCGAAAAGCGGGGG	0.657000													18	29					0	0	1	0	0
PSMA8	143471	broad.mit.edu	37	18	23724622	23724622	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr18:23724622G>C	ENST00000308268.6	+	2	291	c.202G>C	c.(202-204)Gat>Cat	p.D68H	PSMA8_ENST00000343848.6_Intron|PSMA8_ENST00000415576.2_Missense_Mutation_p.D68H	NM_001025096.1|NM_144662.2	NP_001020267.1|NP_653263.2	Q8TAA3	PSA7L_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 8	68					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|skin(2)	16	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)			TTGTGCCCTTGATGACCATGT	0.423000													10	81					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12300302	12300302	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:12300302G>C	ENST00000261349.4	-	15	3471	c.3395C>G	c.(3394-3396)tCa>tGa	p.S1132*	LRP6_ENST00000543091.1_Nonsense_Mutation_p.S1132*	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1132	Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				TTGGGTACCTGAGAGATCACT	0.383000													12	87					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916891	178916891	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr3:178916891G>A	ENST00000263967.3	+	2	435	c.278G>A	c.(277-279)cGg>cAg	p.R93Q		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	93	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R93Q(11)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGTGACCTTCGGCTTTTTCAA	0.343000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			5	82					0	0	1	0	0
RPS12	6206	broad.mit.edu	37	6	133137650	133137650	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr6:133137650A>G	ENST00000230050.3	+	4	392	c.182A>G	c.(181-183)tAt>tGt	p.Y61C		NM_001016.3	NP_001007.2	P25398	RS12_HUMAN	ribosomal protein S12	61					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	structural constituent of ribosome			endometrium(1)|kidney(13)|lung(3)|urinary_tract(1)	18	Breast(56;0.214)			OV - Ovarian serous cystadenocarcinoma(155;0.00284)|GBM - Glioblastoma multiforme(226;0.0256)		GAGCCTATGTATGTCAAGTTG	0.428000													16	62					0	0	1	0	0
KATNAL2	83473	broad.mit.edu	37	18	44627329	44627329	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr18:44627329C>G	ENST00000245121.5	+	15	1548	c.1354C>G	c.(1354-1356)Ctg>Gtg	p.L452V	KATNAL2_ENST00000356157.7_Missense_Mutation_p.L524V	NM_031303.2	NP_112593.2	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	524						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			central_nervous_system(2)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	27						CGCAAAGAATCTGGCTCAGAG	0.488000											OREG0024959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	34					0	0	1	0	0
CPB1	1360	broad.mit.edu	37	3	148558522	148558522	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr3:148558522C>T	ENST00000491148.1	+	5	656	c.322C>T	c.(322-324)Cgg>Tgg	p.R108W	CPB1_ENST00000282957.4_Missense_Mutation_p.R108W			P15086	CBPB1_HUMAN	carboxypeptidase B1 (tissue)	108					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	38			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			GTTTGATAGCCGGGTTCGTGC	0.428000													20	41					0	0	1	0	0
NSRP1	84081	broad.mit.edu	37	17	28511683	28511683	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:28511683C>G	ENST00000247026.5	+	7	731	c.668C>G	c.(667-669)tCa>tGa	p.S223*	NSRP1_ENST00000540900.3_3'UTR	NM_001261467.1|NM_032141.3	NP_001248396.1|NP_115517.1	Q9H0G5	NSRP1_HUMAN	nuclear speckle splicing regulatory protein 1	223					developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding			autonomic_ganglia(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	14						GAAGTAAGTTCAAAAAACAGA	0.373000													24	43					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33165194	33165194	+	Splice_Site	SNP	A	A	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr14:33165194A>T	ENST00000280979.4	+	9	3049		c.e9-1		AKAP6_ENST00000557272.1_Splice_Site|AKAP6_ENST00000557354.1_Splice_Site	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6						protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CCTTATCTTCAGGCTTCTGGA	0.388000													31	41					0	0	1	0	0
CSTL1	128817	broad.mit.edu	37	20	23424606	23424606	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr20:23424606G>C	ENST00000347397.1	+	3	501	c.255G>C	c.(253-255)aaG>aaC	p.K85N	CSTL1_ENST00000246020.2_Missense_Mutation_p.K85N	NM_138283.1	NP_612140.1	Q9H114	CST1L_HUMAN	cystatin-like 1	85						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(2)|endometrium(2)|large_intestine(3)|lung(4)|skin(2)|stomach(1)	14	Colorectal(13;0.0993)|Lung NSC(19;0.235)					TCACTGTGAAGATTGGCTGGA	0.512000													7	38					0	0	1	0	0
ALG1	56052	broad.mit.edu	37	16	5127977	5127977	+	Silent	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr16:5127977C>G	ENST00000588623.1	+	7	1466	c.366C>G	c.(364-366)ctC>ctG	p.L122L	ALG1_ENST00000544428.1_Silent_p.L122L|ALG1_ENST00000262374.5_Silent_p.L233L			Q9BT22	ALG1_HUMAN	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase	233					dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Ovarian(90;0.0164)				AGCACCGGCTCTTCATGAAGC	0.597000													25	68					0	0	1	0	0
STEAP1	26872	broad.mit.edu	37	7	89790153	89790153	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr7:89790153G>C	ENST00000297205.2	+	3	319	c.119G>C	c.(118-120)aGa>aCa	p.R40T	STEAP2-AS1_ENST00000478318.2_RNA	NM_012449.2	NP_036581.1	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the prostate 1	40					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			kidney(2)|large_intestine(3)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	14	all_hematologic(106;0.112)					ATGCTAAAAAGACCTGTGCTT	0.408000													30	126					0	0	1	0	0
GCNT2	2651	broad.mit.edu	37	6	10556716	10556716	+	Silent	SNP	C	C	T	rs55665031		TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr6:10556716C>T	ENST00000316170.3	+	1	477	c.60C>T	c.(58-60)atC>atT	p.I20I	GCNT2_ENST00000495262.1_Intron|GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000397423.2_Intron	NM_001491.2	NP_001482.1	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	21						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TTATTTTTATCGTCTTCTCTG	0.388000													9	89					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55972868	55972868	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr4:55972868C>T	ENST00000263923.4	-	11	1817	c.1522G>A	c.(1522-1524)Gaa>Aaa	p.E508K		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	508	Ig-like C2-type 5.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TTTTTTCCTTCAATTAGAGCA	0.333000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			3	38					0	0	1	0	0
CXorf67	340602	broad.mit.edu	37	X	51150761	51150761	+	Missense_Mutation	SNP	T	T	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chrX:51150761T>G	ENST00000342995.2	+	1	995	c.893T>G	c.(892-894)gTc>gGc	p.V298G						chromosome X open reading frame 67											breast(1)|endometrium(4)|large_intestine(1)|lung(11)|ovary(3)|prostate(1)	21						TCTGCGCCAGTCTCTGCCCCC	0.746000													2	0					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112216856	112216856	+	Splice_Site	SNP	T	T	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr9:112216856T>A	ENST00000374541.2	-	5	394		c.e5-2		PTPN3_ENST00000262539.3_Intron	NM_001145368.1|NM_002829.3	NP_001138840.1|NP_002820.3	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3						negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						GGAAACCTCCTACAACATTTT	0.343000													58	12					0	0	1	0	0
DNAJB1	3337	broad.mit.edu	37	19	14629110	14629110	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr19:14629110C>T	ENST00000254322.2	-	1	122	c.52G>A	c.(52-54)Gag>Aag	p.E18K	DNAJB1_ENST00000396969.4_Intron	NM_006145.1	NP_006136.1	P25685	DNJB1_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 1	18	J.				chaperone cofactor-dependent protein refolding|response to unfolded protein	cytoplasm|nucleolus	heat shock protein binding|unfolded protein binding	p.E18K(1)		NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|urinary_tract(1)	16				GBM - Glioblastoma multiforme(1328;0.0476)		TTGATCTCCTCGTCCGACGCG	0.701000													16	26					0	0	1	0	0
ATMIN	23300	broad.mit.edu	37	16	81078153	81078153	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr16:81078153C>T	ENST00000566488.1	+	3	2545	c.1582C>T	c.(1582-1584)Cag>Tag	p.Q528*	ATMIN_ENST00000539819.1_3'UTR|ATMIN_ENST00000564241.1_Nonsense_Mutation_p.Q528*|ATMIN_ENST00000299575.4_Nonsense_Mutation_p.Q684*			O43313	ATMIN_HUMAN	ATM interactor	684					response to DNA damage stimulus	nucleus	zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	20						TACCTCTGCTCAGTCCTATGG	0.458000													59	70					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101563938	101563938	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr10:101563938G>C	ENST00000370449.4	+	10	1485	c.1372G>C	c.(1372-1374)Gag>Cag	p.E458Q		NM_000392.3	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	458	ABC transmembrane type-1 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCTATGGAGAGAGTTGGGACC	0.458000													12	49					0	0	1	0	0
TTF1	7270	broad.mit.edu	37	9	135277549	135277549	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr9:135277549C>G	ENST00000334270.2	-	2	699	c.660G>C	c.(658-660)aaG>aaC	p.K220N		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	220	N-terminal region (NRD) (By similarity).|Poly-Lys.				negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		TCTTTTTTTTCTTAGACTTGT	0.498000													11	22					0	0	1	0	0
GLUD1P7	414212	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													4	23					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37678028	37678028	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr19:37678028C>T	ENST00000532828.2	-	5	662	c.411G>A	c.(409-411)aaG>aaA	p.K137K	ZNF585B_ENST00000527838.1_Silent_p.K137K|ZNF585B_ENST00000312908.5_5'UTR|ZNF585B_ENST00000531805.1_Silent_p.K82K|CTC-454I21.3_ENST00000585860.2_Intron	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGGTGAAGCTCTTTCCAAATT	0.373000													11	96					0	0	1	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6442266	6442266	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:6442266G>C	ENST00000162749.2	-	5	819	c.520C>G	c.(520-522)Cta>Gta	p.L174V	TNFRSF1A_ENST00000437813.3_5'UTR|TNFRSF1A_ENST00000540022.1_Missense_Mutation_p.L131V|TNFRSF1A_ENST00000366159.4_Missense_Mutation_p.L174V	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	174					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						TTTTCTCTTAGAAAGAAACCT	0.567000													8	64					0	0	1	0	0
NOP56	10528	broad.mit.edu	37	20	2638826	2638826	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr20:2638826G>C	ENST00000329276.5	+	12	2187	c.1671G>C	c.(1669-1671)aaG>aaC	p.K557N	NOP56_ENST00000492135.1_3'UTR	NM_006392.3	NP_006383.2	O00567	NOP56_HUMAN	NOP56 ribonucleoprotein	557	Lys-rich.				rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25						GTGGCTCCAAGAAAAAGAGGA	0.512000													6	13					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30673315	30673315	+	Silent	SNP	G	G	T	rs149345627	byFrequency	TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr6:30673315G>T	ENST00000376406.3	-	10	4292	c.3645C>A	c.(3643-3645)acC>acA	p.T1215T	MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Silent_p.T951T	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1215	Interaction with the PRKDC complex.|Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						CAGGTCGGTCGGTGGAGGTGG	0.542000								Other conserved DNA damage response genes					5	133					1	1	1	1	0
STAU1	6780	broad.mit.edu	37	20	47770604	47770604	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr20:47770604G>C	ENST00000371856.2	-	4	620	c.210C>G	c.(208-210)agC>agG	p.S70R	STAU1_ENST00000347458.5_5'UTR|STAU1_ENST00000371828.3_5'UTR|STAU1_ENST00000371802.1_5'UTR|STAU1_ENST00000340954.7_5'UTR|STAU1_ENST00000371792.1_5'UTR|STAU1_ENST00000360426.4_5'UTR	NM_017453.2	NP_059347.2	O95793	STAU1_HUMAN	staufen double-stranded RNA binding protein 1	70						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	23			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			TAGGGGTTATGCTTTCTGCAA	0.363000													6	78					0	0	1	0	0
CTSD	1509	broad.mit.edu	37	11	1780260	1780260	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:1780260G>A	ENST00000236671.2	-	4	542	c.410C>T	c.(409-411)tCg>tTg	p.S137L	RP11-295K3.1_ENST00000427721.1_Missense_Mutation_p.R8C	NM_001909.4	NP_001900.1	P07339	CATD_HUMAN	cathepsin D	137					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(8)	13		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GATGTCAAACGAGGTACCATT	0.637000													7	126					0	0	1	0	0
PHACTR2	9749	broad.mit.edu	37	6	144109920	144109920	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr6:144109920G>C	ENST00000427704.2	+	11	1815	c.1685G>C	c.(1684-1686)aGa>aCa	p.R562T	PHACTR2_ENST00000440869.2_Missense_Mutation_p.R573T|PHACTR2_ENST00000305766.6_Missense_Mutation_p.R482T|PHACTR2_ENST00000367582.3_Missense_Mutation_p.R493T|PHACTR2_ENST00000367584.4_Missense_Mutation_p.R550T	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2	562							actin binding|protein phosphatase inhibitor activity	p.R482I(1)|p.R573I(1)		NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		CTCAGCCTGAGACCCACAGTG	0.488000													13	32					0	0	1	0	0
GOLGA6L17P	642402	broad.mit.edu	37	15	85053124	85053124	+	RNA	SNP	G	G	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr15:85053124G>T	ENST00000414190.2	-	0	328					NR_003246.2																						TAAATGTTTTGTTTTTTTTTT	0.353000													3	9					0.000602214	0.000623944	1	1	0
ZMYM6	9204	broad.mit.edu	37	1	35478084	35478084	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:35478084G>C	ENST00000357182.4	-	7	1121	c.894C>G	c.(892-894)ttC>ttG	p.F298L	ZMYM6_ENST00000487874.1_Missense_Mutation_p.F298L|ZMYM6_ENST00000373340.2_Missense_Mutation_p.F298L|ZMYM6_ENST00000493328.1_5'UTR	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	298					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				TAATAGAGCAGAAAAGCTCTG	0.343000													4	43					0	0	1	0	0
ETV1	2115	broad.mit.edu	37	7	13978872	13978872	+	Splice_Site	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr7:13978872C>G	ENST00000343495.5	-	6	920		c.e6-1		ETV1_ENST00000420159.2_Splice_Site|ETV1_ENST00000403527.1_Splice_Site|ETV1_ENST00000405192.2_Splice_Site|ETV1_ENST00000399357.3_Splice_Site|ETV1_ENST00000242066.5_Splice_Site|ETV1_ENST00000405218.2_Splice_Site|ETV1_ENST00000405358.4_Splice_Site|ETV1_ENST00000403685.1_Splice_Site|ETV1_ENST00000476720.2_Splice_Site|ETV1_ENST00000430479.1_Splice_Site			P50549	ETV1_HUMAN	ets variant 1						transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						TGAAAAGCCACTAGAAAAAAG	0.368000			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								31	24					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6623646	6623646	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:6623646C>G	ENST00000315579.5	+	8	1531	c.732C>G	c.(730-732)atC>atG	p.I244M	NCAPD2_ENST00000545962.1_Missense_Mutation_p.I199M	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	244	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						CAGTGAAGATCATCCAGATGC	0.468000													39	51					0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10629302	10629302	+	Silent	SNP	G	G	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr20:10629302G>T	ENST00000254958.5	-	12	1979	c.1464C>A	c.(1462-1464)atC>atA	p.I488I	JAG1_ENST00000423891.2_Silent_p.I329I	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	488	EGF-like 8; calcium-binding (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						CACATTCATCGATGTCTCTCT	0.483000									Alagille Syndrome				17	29					0.00400662	0.00410883	1	1	0
ATMIN	23300	broad.mit.edu	37	16	81078378	81078378	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr16:81078378C>G	ENST00000566488.1	+	3	2770	c.1807C>G	c.(1807-1809)Cag>Gag	p.Q603E	ATMIN_ENST00000539819.1_3'UTR|ATMIN_ENST00000564241.1_Missense_Mutation_p.Q603E|ATMIN_ENST00000299575.4_Missense_Mutation_p.Q759E			O43313	ATMIN_HUMAN	ATM interactor	759					response to DNA damage stimulus	nucleus	zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	20						AAGCAAAGTTCAGTTGAACAG	0.448000													25	46					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69020480	69020480	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr8:69020480C>G	ENST00000288368.4	+	24	3129	c.2852C>G	c.(2851-2853)tCa>tGa	p.S951*		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	951					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CCCAAAACATCAACCTCTTTG	0.408000													8	61					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65384336	65384336	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:65384336C>T	ENST00000355703.3	+	2	734	c.195C>T	c.(193-195)ctC>ctT	p.L65L		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	65						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						TGTACTGCCTCGTGGTGGCTG	0.547000													8	83					0	0	1	0	0
ANAPC5	51433	broad.mit.edu	37	12	121773363	121773363	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:121773363G>A	ENST00000261819.3	-	7	1044	c.923C>T	c.(922-924)gCc>gTc	p.A308V	ANAPC5_ENST00000544314.1_5'UTR|ANAPC5_ENST00000344395.4_Missense_Mutation_p.A209V|ANAPC5_ENST00000541887.1_Missense_Mutation_p.A308V|ANAPC5_ENST00000441917.2_Missense_Mutation_p.A209V|ANAPC5_ENST00000536366.1_Missense_Mutation_p.A187V	NM_016237.4	NP_057321.2	Q9UJX4	APC5_HUMAN	anaphase promoting complex subunit 5	308					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(6)|endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(3)	31	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GTGCAGGGCGGCAAGATTCAG	0.488000													4	202					0	0	1	0	0
MAVS	57506	broad.mit.edu	37	20	3846494	3846494	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr20:3846494C>T	ENST00000428216.2	+	7	1451	c.1323C>T	c.(1321-1323)atC>atT	p.I441I	MAVS_ENST00000416600.2_Silent_p.I300I|MAVS_ENST00000358134.6_3'UTR	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein	441					activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						ATCTTGCCATCAGTGCCAGCA	0.612000													7	57					0	0	1	0	0
RALYL	138046	broad.mit.edu	37	8	85774568	85774568	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr8:85774568C>T	ENST00000521268.1	+	6	1556	c.451C>T	c.(451-453)Cgt>Tgt	p.R151C	RALYL_ENST00000518566.1_Missense_Mutation_p.R140C|RALYL_ENST00000522455.1_Missense_Mutation_p.R151C|RALYL_ENST00000523850.1_Missense_Mutation_p.R78C|RALYL_ENST00000521695.1_Missense_Mutation_p.R151C|RALYL_ENST00000521376.1_Missense_Mutation_p.R62C|RALYL_ENST00000517638.1_Missense_Mutation_p.R164C	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	151							identical protein binding|nucleotide binding|RNA binding	p.R151G(4)		endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						TCCACCTCCCCGTGCAGTAAT	0.502000													7	10					0	0	1	0	0
CYP26A1	1592	broad.mit.edu	37	10	94834237	94834237	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr10:94834237G>A	ENST00000371531.1	+	2	533	c.155G>A	c.(154-156)gGa>gAa	p.G52E	CYP26A1_ENST00000394139.1_Missense_Mutation_p.G52E|CYP26A1_ENST00000224356.4_Missense_Mutation_p.G121E	NM_057157.2	NP_476498.1	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A, polypeptide 1	121					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Colorectal(252;0.122)				ACCATTCTGGGATCTGGCTGC	0.652000													11	157					0	0	1	0	0
UBE2B	7320	broad.mit.edu	37	5	133724024	133724024	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr5:133724024G>A	ENST00000265339.2	+	5	667	c.250G>A	c.(250-252)Gat>Aat	p.D84N	UBE2B_ENST00000511807.1_Intron	NM_003337.2	NP_003328.1	P63146	UBE2B_HUMAN	ubiquitin-conjugating enzyme E2B	84					canonical Wnt receptor signaling pathway|histone H2A ubiquitination|negative regulation of cAMP-mediated signaling|postreplication repair|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein stabilization|response to drug|response to UV	cytoplasm|plasma membrane|replication fork	ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity			kidney(1)|large_intestine(2)|lung(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGTGTATGCTGATGGTAGCAT	0.348000								Rad6 pathway					7	45					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54790078	54790078	+	Nonstop_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:54790078C>G	ENST00000293379.4	-	30	3410	c.3149G>C	c.(3148-3150)tGa>tCa	p.*1050S	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						TGGGAGGACTCAGGCATCAGA	0.527000													7	33					0	0	1	0	0
GPR155	151556	broad.mit.edu	37	2	175338037	175338037	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr2:175338037C>T	ENST00000392552.2	-	3	754	c.516G>A	c.(514-516)gtG>gtA	p.V172V	GPR155_ENST00000392551.2_Silent_p.V172V|GPR155_ENST00000295500.4_Silent_p.V172V	NM_001267051.1|NM_152529.6	NP_001253980.1|NP_689742.4	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155	172					intracellular signal transduction|transmembrane transport	integral to membrane				breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	26						ATATTGGTGCCACCAAATAAA	0.299000													12	76					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101092487	101092487	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr8:101092487G>C	ENST00000360863.6	-	4	408	c.214C>G	c.(214-216)Cta>Gta	p.L72V	RGS22_ENST00000523437.1_Missense_Mutation_p.L72V|RGS22_ENST00000523287.1_5'UTR	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	72					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGGTTTTGTAGAATTTTTTTC	0.368000													39	43					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61539053	61539053	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:61539053G>C	ENST00000278836.5	+	6	918	c.822G>C	c.(820-822)atG>atC	p.M274I	MYRF_ENST00000265460.5_Missense_Mutation_p.M265I|TMEM258_ENST00000535042.1_Intron	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		TGAATGGAATGATCAAACAGG	0.637000													19	71					0	0	1	0	0
RHOBTB3	22836	broad.mit.edu	37	5	95124488	95124488	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr5:95124488C>G	ENST00000379982.3	+	11	2154	c.1646C>G	c.(1645-1647)tCa>tGa	p.S549*	GLRX_ENST00000508780.1_Intron|RHOBTB3_ENST00000504179.1_Nonsense_Mutation_p.S180*|GLRX_ENST00000507605.1_Intron	NM_014899.3	NP_055714.3	O94955	RHBT3_HUMAN	Rho-related BTB domain containing 3	549	Interaction with Rab9.				retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|skin(1)	16		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		GATTGCCTTTCAACCTGGCTA	0.378000													7	60					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130761712	130761712	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr8:130761712G>A	ENST00000276708.4	-	13	2154	c.1273C>T	c.(1273-1275)Cag>Tag	p.Q425*		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	425						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						TCCTGTTGCTGAAGCAGGATC	0.517000													6	43					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130832682	130832682	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:130832682C>T	ENST00000245255.3	+	7	960	c.688C>T	c.(688-690)Cga>Tga	p.R230*		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	230					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ACAAATTGGACGAAATTATTA	0.328000													13	66					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14827586	14827586	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:14827586G>C	ENST00000261170.3	-	8	1193	c.1057C>G	c.(1057-1059)Cat>Gat	p.H353D	RP11-174G6.1_ENST00000501178.2_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	353					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						CTGAAAGCATGAGCAAATTTG	0.398000													14	94					0	0	1	0	0
ELAC1	55520	broad.mit.edu	37	18	48510681	48510681	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr18:48510681C>T	ENST00000269466.3	+	3	480	c.373C>T	c.(373-375)Cct>Tct	p.P125S	SMAD4_ENST00000452201.2_Intron|RP11-729L2.2_ENST00000590722.2_Intron|ELAC1_ENST00000591429.1_Missense_Mutation_p.P125S|ELAC1_ENST00000588577.1_Intron|RP11-729L2.2_ENST00000588256.1_Intron	NM_018696.2	NP_061166.1	Q9H777	RNZ1_HUMAN	elaC ribonuclease Z 1	125					tRNA 3'-trailer cleavage	nucleus	endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			kidney(1)|large_intestine(4)|prostate(1)	6		Colorectal(6;0.0269)|all_epithelial(6;0.0729)		Colorectal(21;0.000943)|COAD - Colon adenocarcinoma(17;0.0398)|READ - Rectum adenocarcinoma(32;0.0894)|STAD - Stomach adenocarcinoma(97;0.18)		TGAACTGGTTCCTACAGCAGA	0.463000													30	24					0	0	1	0	0
C1orf131	128061	broad.mit.edu	37	1	231376885	231376885	+	Translation_Start_Site	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:231376885C>T	ENST00000318906.2	-	1	31	c.3G>A	c.(1-3)atG>atA	p.M1I	C1orf131_ENST00000366649.2_Start_Codon_SNP_p.M1I|C1orf131_ENST00000366651.3_Start_Codon_SNP_p.M1I|C1orf131_ENST00000471936.1_5'UTR			Q8NDD1	CA131_HUMAN	chromosome 1 open reading frame 131	1										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	8	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				AATCAACCCTCATTCTGCCGC	0.687000													16	47					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25251866	25251866	+	Silent	SNP	C	C	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr16:25251866C>A	ENST00000328086.7	-	7	2978	c.2175G>T	c.(2173-2175)ccG>ccT	p.P725P		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	725					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		GCTGAGACATCGGCTTTCCCT	0.463000													28	41					7.38237e-10	7.80977e-10	1	1	0
OR7C1	26664	broad.mit.edu	37	19	14910903	14910903	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr19:14910903C>A	ENST00000248073.2	-	1	120	c.46G>T	c.(46-48)Gga>Tga	p.G16*	OR7A5_ENST00000601611.1_Intron	NM_198944.1	NP_945182.1	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C, member 1	16					sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(2)|ovary(2)|prostate(1)	18						GCTGAAAATCCCAGGAGGAGA	0.438000													51	93					3.19069e-20	3.42956e-20	1	1	0
TTC29	83894	broad.mit.edu	37	4	147796023	147796023	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr4:147796023C>T	ENST00000513335.1	-	8	921	c.722G>A	c.(721-723)cGg>cAg	p.R241Q	TTC29_ENST00000325106.4_Missense_Mutation_p.R215Q|TTC29_ENST00000398886.4_Missense_Mutation_p.R241Q			Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	215							binding			breast(2)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					CTTCCATATCCGCCCCTGTGT	0.448000													16	27					0	0	1	0	0
ST8SIA2	8128	broad.mit.edu	37	15	92987900	92987900	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr15:92987900G>C	ENST00000268164.3	+	5	820	c.583G>C	c.(583-585)Gat>Cat	p.D195H	ST8SIA2_ENST00000539113.1_Missense_Mutation_p.D174H	NM_006011.3	NP_006002.1	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	195					axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(2)|large_intestine(6)|lung(9)|skin(2)|urinary_tract(1)	20	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			GTATGCCCGGGATGTGGGGCT	0.567000													9	49					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17764700	17764700	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr6:17764700C>T	ENST00000378814.5	-	37	4914	c.4915G>A	c.(4915-4917)Gag>Aag	p.E1639K	KIF13A_ENST00000259711.6_Missense_Mutation_p.E1687K|KIF13A_ENST00000378843.2_Missense_Mutation_p.E1639K|KIF13A_ENST00000378816.5_Missense_Mutation_p.E1652K|KIF13A_ENST00000378826.2_Missense_Mutation_p.E1652K	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	1687					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			GAGTTTTTCTCAGGGATGCTC	0.507000													7	59					0	0	1	0	0
GSTA3	2940	broad.mit.edu	37	6	52764869	52764869	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr6:52764869C>G	ENST00000211122.3	-	5	342	c.277G>C	c.(277-279)Gat>Cat	p.D93H	GSTA3_ENST00000370968.1_Missense_Mutation_p.D43H	NM_000847.4	NP_000838.3	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	93	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)	10	Lung NSC(77;0.0912)				Glutathione(DB00143)	GTATACATATCAATTCTGAAA	0.378000													11	65					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21407359	21407359	+	Silent	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr18:21407359G>A	ENST00000313654.9	+	23	2992	c.2751G>A	c.(2749-2751)ggG>ggA	p.G917G	LAMA3_ENST00000399516.3_Silent_p.G917G	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	917	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCTTGATGGGGAGCCAAGAC	0.542000													13	82					0	0	1	0	0
PLSCR2	57047	broad.mit.edu	37	3	146167020	146167020	+	Silent	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr3:146167020G>A	ENST00000497985.1	-	8	1276	c.837C>T	c.(835-837)gcC>gcT	p.A279A	PLSCR2_ENST00000336685.2_Silent_p.A206A	NM_001199978.1	NP_001186907.1	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	206					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity			endometrium(2)|large_intestine(5)|lung(7)|stomach(1)	15						CAATCATCACGGCTTTCATTT	0.383000													46	68					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139193134	139193134	+	Silent	SNP	G	G	A	rs115268774	by1000genomes	TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr5:139193134G>A	ENST00000274710.3	+	3	817	c.612G>A	c.(610-612)gcG>gcA	p.A204A		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	204					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGACATGGCGTTTGAGGGGG	0.687000													5	37					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332492	22332492	+	RNA	SNP	A	A	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr15:22332492A>C	ENST00000558896.1	+	0	299																											TATTTCTCTTATTACTATTTT	0.383000													6	181					0	0	1	0	0
MLXIP	22877	broad.mit.edu	37	12	122618268	122618268	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:122618268C>G	ENST00000319080.7	+	9	1598	c.1466C>G	c.(1465-1467)tCt>tGt	p.S489C	MLXIP_ENST00000538698.1_Missense_Mutation_p.S96C|MLXIP_ENST00000377037.2_Missense_Mutation_p.S79C			Q9HAP2	MLXIP_HUMAN	MLX interacting protein						regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		CACACGGCCTCTGCCACCCTC	0.647000													7	11					0	0	1	0	0
YWHAH	7533	broad.mit.edu	37	22	32352214	32352214	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr22:32352214C>T	ENST00000248975.5	+	2	449	c.176C>T	c.(175-177)tCc>tTc	p.S59F	YWHAH_ENST00000397492.1_3'UTR|YWHAH_ENST00000471374.1_3'UTR	NM_003405.3	NP_003396.1	Q04917	1433F_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	59					glucocorticoid catabolic process|glucocorticoid receptor signaling pathway|intracellular protein transport|negative regulation of dendrite morphogenesis|positive regulation of transcription, DNA-dependent|regulation of synaptic plasticity	cytoplasm	enzyme binding|glucocorticoid receptor binding|insulin-like growth factor receptor binding|protein domain specific binding			breast(1)|central_nervous_system(1)|large_intestine(1)|upper_aerodigestive_tract(1)	4						AGGCGATCTTCCTGGAGGGTC	0.473000													3	58					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112476111	112476111	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr6:112476111T>A	ENST00000230538.7	-	16	2395	c.1998A>T	c.(1996-1998)aaA>aaT	p.K666N	RP1-142L7.5_ENST00000425503.1_RNA|RP1-142L7.5_ENST00000585373.1_RNA|LAMA4_ENST00000424408.2_Missense_Mutation_p.K659N|LAMA4_ENST00000389463.4_Missense_Mutation_p.K659N|LAMA4_ENST00000522006.1_Missense_Mutation_p.K659N|RP1-142L7.5_ENST00000588689.1_RNA	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	666	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CACTTTCATCTTTATGGTAAA	0.378000													44	51					0	0	1	0	0
IL18R1	8809	broad.mit.edu	37	2	103006635	103006635	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr2:103006635C>T	ENST00000409599.1	+	10	1425	c.1069C>T	c.(1069-1071)Cta>Tta	p.L357L	IL18R1_ENST00000233957.1_Silent_p.L357L			Q13478	IL18R_HUMAN	interleukin 18 receptor 1	357					innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			breast(1)|endometrium(3)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						TGACTTGGTTCTATTTTATAG	0.358000													5	47					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98205966	98205966	+	Silent	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:98205966G>A	ENST00000370192.3	-	4	403	c.303C>T	c.(301-303)atC>atT	p.I101I	DPYD_ENST00000306031.5_Silent_p.I101I|DPYD_ENST00000423006.2_Silent_p.I64I	NM_000110.3	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	101					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CAATACTTGTGATGAATGATT	0.333000													32	59					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178921553	178921553	+	Missense_Mutation	SNP	T	T	A	rs121913284		TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr3:178921553T>A	ENST00000263967.3	+	5	1192	c.1035T>A	c.(1033-1035)aaT>aaA	p.N345K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	345					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.N345K(44)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCTACGTGAATGTAAATATTC	0.308000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			42	51					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406010	55406010	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:55406010C>T	ENST00000314612.2	+	1	177	c.177C>T	c.(175-177)ttC>ttT	p.F59F		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						CCATGTATTTCTTCCTCAATT	0.393000													6	35					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82321747	82321747	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr9:82321747C>T	ENST00000376520.4	+	11	1697	c.869C>T	c.(868-870)cCg>cTg	p.P290L	TLE4_ENST00000376544.3_Intron|TLE4_ENST00000376537.4_Missense_Mutation_p.P290L|TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000376552.2_Missense_Mutation_p.P290L|TLE4_ENST00000265284.6_Missense_Mutation_p.P265L	NM_001282748.1	NP_001269677.1	O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						AAAGATGCCCCGATTAGTCCA	0.517000													66	22					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57891140	57891140	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr4:57891140A>G	ENST00000381227.1	+	23	3466	c.3053A>G	c.(3052-3054)tAt>tGt	p.Y1018C	POLR2B_ENST00000431623.2_Missense_Mutation_p.Y943C|POLR2B_ENST00000441246.2_Missense_Mutation_p.Y1011C|POLR2B_ENST00000314595.5_Missense_Mutation_p.Y1018C			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	1018					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					TTATCTGATTATGGCTATCAT	0.323000													19	60					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144891871	144891871	+	Silent	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr8:144891871G>A	ENST00000356994.2	-	14	1554	c.1548C>T	c.(1546-1548)gcC>gcT	p.A516A	SCRIB_ENST00000377533.3_Silent_p.A435A|SCRIB_ENST00000320476.3_Silent_p.A516A	NM_182706.4	NP_874365	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	516	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GGCCAGACTCGGCACTCAGCC	0.692000													12	42					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56468844	56468844	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr6:56468844T>C	ENST00000370754.5	-	39	10482	c.10483A>G	c.(10483-10485)Att>Gtt	p.I3495V	DST_ENST00000312431.6_Missense_Mutation_p.I3317V|DST_ENST00000446842.2_Missense_Mutation_p.I2991V|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000361203.3_Missense_Mutation_p.I3317V|DST_ENST00000244364.6_Intron|DST_ENST00000370769.4_Missense_Mutation_p.I3317V			Q03001	DYST_HUMAN	dystonin	3317					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCACCAAGAATATGTGGCTTT	0.348000													13	10					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1017526	1017526	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:1017526G>C	ENST00000421673.2	-	31	5325	c.5275C>G	c.(5275-5277)Cct>Gct	p.P1759A		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1759	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTGACTTCAGGATGGTGTGTG	0.562000													5	479					0	0	1	0	0
CASKIN1	57524	broad.mit.edu	37	16	2233845	2233845	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr16:2233845C>T	ENST00000343516.6	-	15	1606	c.1514G>A	c.(1513-1515)cGc>cAc	p.R505H	CASKIN1_ENST00000564289.1_Intron	NM_020764.3	NP_065815.1	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	505	SAM 1.				signal transduction	cytoplasm				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|liver(1)|lung(7)|ovary(4)|prostate(5)|skin(3)	28						GGGAGTCATGCGGCTGATGGT	0.667000													4	49					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123220456	123220456	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chrX:123220456G>A	ENST00000371160.1	+	30	3403	c.3113G>A	c.(3112-3114)tGg>tAg	p.W1038*	STAG2_ENST00000371157.3_Nonsense_Mutation_p.W1038*|STAG2_ENST00000371144.3_Nonsense_Mutation_p.W1038*|STAG2_ENST00000371145.3_Nonsense_Mutation_p.W1038*|STAG2_ENST00000354548.5_Nonsense_Mutation_p.W969*|STAG2_ENST00000218089.9_Nonsense_Mutation_p.W1038*|STAG2_ENST00000469481.1_Intron	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	1038					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						GAGGATGTGTGGCTTCCACTG	0.438000													36	7					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173881124	173881124	+	Silent	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr2:173881124C>G	ENST00000264111.6	+	19	2041	c.1854C>G	c.(1852-1854)ctC>ctG	p.L618L	RAPGEF4_ENST00000409036.1_Silent_p.L619L|RAPGEF4_ENST00000535187.1_Silent_p.L399L|RAPGEF4_ENST00000397081.3_Silent_p.L619L|RAPGEF4_ENST00000538974.1_Silent_p.L448L|RAPGEF4_ENST00000539331.1_Silent_p.L466L|RAPGEF4_ENST00000540783.1_Silent_p.L466L|RAPGEF4_ENST00000397087.3_Silent_p.L475L			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	619	N-terminal Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			TTGCTGCCCTCAAGGAGCAAC	0.433000													6	52					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77739431	77739431	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr13:77739431C>T	ENST00000407578.2	-	42	6702	c.6436G>A	c.(6436-6438)Gaa>Aaa	p.E2146K	MYCBP2_ENST00000357337.6_Missense_Mutation_p.E2108K|MYCBP2_ENST00000544440.2_Missense_Mutation_p.E2108K|MYCBP2_ENST00000360084.5_5'UTR	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	2108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GGGCTAAATTCATATCCAATT	0.358000													16	111					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48145564	48145564	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:48145564G>T	ENST00000405493.2	-	4	405	c.196C>A	c.(196-198)Ctg>Atg	p.L66M	RAPGEF3_ENST00000389212.3_Missense_Mutation_p.L108M|RAPGEF3_ENST00000548919.1_Missense_Mutation_p.L66M|RAPGEF3_ENST00000449771.2_Missense_Mutation_p.L108M|RAPGEF3_ENST00000395358.3_Missense_Mutation_p.L108M|RAPGEF3_ENST00000171000.4_Missense_Mutation_p.L66M|RAPGEF3_ENST00000549151.1_Missense_Mutation_p.L66M	NM_001098532.2|NM_006105.5	NP_001092002|NP_006096	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	66					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GTGGCCAGCAGATGCCGATGC	0.627000													4	31					0.00909568	0.00923349	1	1	0
SUGP2	10147	broad.mit.edu	37	19	19115047	19115047	+	Silent	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr19:19115047G>A	ENST00000601879.1	-	7	3156	c.2859C>T	c.(2857-2859)atC>atT	p.I953I	SUGP2_ENST00000456085.2_Silent_p.I722I|SUGP2_ENST00000337018.6_Silent_p.I953I|SUGP2_ENST00000600377.1_Silent_p.I967I|SUGP2_ENST00000452918.2_Silent_p.I953I			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	953					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						ACTTGCTGCTGATCCTCTTCC	0.612000													7	58					0	0	1	0	0
LRRC47	57470	broad.mit.edu	37	1	3699310	3699310	+	Missense_Mutation	SNP	T	T	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:3699310T>G	ENST00000378251.1	-	5	1355	c.1328A>C	c.(1327-1329)gAt>gCt	p.D443A		NM_020710.2	NP_065761.1	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	443					translation		phenylalanine-tRNA ligase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	17	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		TTCATTTCCATCCAGCAAGTG	0.453000													5	87					0	0	1	0	0
ABCG1	9619	broad.mit.edu	37	21	43714663	43714663	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr21:43714663C>T	ENST00000398437.1	+	15	2287	c.2139C>T	c.(2137-2139)ttC>ttT	p.F713F	ABCG1_ENST00000343687.3_Silent_p.F566F|ABCG1_ENST00000347800.2_Silent_p.F552F|ABCG1_ENST00000462050.1_3'UTR|ABCG1_ENST00000398449.3_Silent_p.F555F|ABCG1_ENST00000398457.2_Silent_p.F557F|ABCG1_ENST00000361802.2_Silent_p.F567F|ABCG1_ENST00000340588.4_Silent_p.F675F			P45844	ABCG1_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 1	567					amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(3)|prostate(2)|stomach(1)	29					Adenosine triphosphate(DB00171)	TGGCCACTTTCGTGGGCCCAG	0.627000													5	39					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31683123	31683123	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr7:31683123C>T	ENST00000319386.3	+	11	2688	c.1695C>T	c.(1693-1695)tcC>tcT	p.S565S	CCDC129_ENST00000451887.2_Silent_p.S739S|CCDC129_ENST00000407970.3_Silent_p.S713S|CCDC129_ENST00000409210.1_Silent_p.S621S			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	713										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						CCCAGATGTCCTCCAGCCTGG	0.532000													9	17					0	0	1	0	0
TWF2	11344	broad.mit.edu	37	3	52265547	52265547	+	Silent	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr3:52265547C>G	ENST00000305533.5	-	4	534	c.291G>C	c.(289-291)ctG>ctC	p.L97L	TLR9_ENST00000597542.1_5'UTR|TWF2_ENST00000499914.2_Silent_p.L97L	NM_007284.3	NP_009215.1			twinfilin actin-binding protein 2											breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|stomach(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;2.43e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		ACAGCATCTTCAGCCGCACCT	0.602000											OREG0015610	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	137					0	0	1	0	0
PRKRIR	5612	broad.mit.edu	37	11	76072059	76072059	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:76072059C>T	ENST00000260045.3	-	3	364	c.259G>A	c.(259-261)Gat>Aat	p.D87N	PRKRIR_ENST00000531878.1_5'UTR	NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	87					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						CTGGTAAGATCAAATATTGTT	0.343000													4	63					0	0	1	0	0
FGF23	8074	broad.mit.edu	37	12	4479899	4479899	+	Silent	SNP	G	G	A	rs145147639		TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:4479899G>A	ENST00000237837.1	-	3	511	c.366C>T	c.(364-366)aaC>aaT	p.N122N		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	122					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CGTCGTACCCGTTTTCCAGCG	0.607000													36	51					0	0	1	0	0
TRIM37	4591	broad.mit.edu	37	17	57148305	57148305	+	Missense_Mutation	SNP	G	G	A	rs142255088		TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:57148305G>A	ENST00000376149.3	-	9	1131	c.322C>T	c.(322-324)Cgg>Tgg	p.R108W	TRIM37_ENST00000393066.3_Missense_Mutation_p.R230W|TRIM37_ENST00000393065.2_Missense_Mutation_p.R196W|TRIM37_ENST00000262294.7_Missense_Mutation_p.R230W			O94972	TRI37_HUMAN	tripartite motif containing 37	230			T -> A (in dbSNP:rs17853504).			perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CTACAAGACCGCAACTGTGTG	0.353000									Mulibrey Nanism				4	66					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126137947	126137947	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr3:126137947G>C	ENST00000393425.1	+	8	781	c.682G>C	c.(682-684)Gag>Cag	p.E228Q	CCDC37_ENST00000505024.1_Missense_Mutation_p.E228Q|CCDC37_ENST00000352312.1_Missense_Mutation_p.E227Q			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	227										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		AGCCAAGATAGAGAAGATCCT	0.592000													5	12					0	0	1	0	0
BAP1	8314	broad.mit.edu	37	3	52437911	52437911	+	Splice_Site	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr3:52437911C>G	ENST00000460680.1	-	13	1722		c.e13-1		BAP1_ENST00000296288.5_Splice_Site	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)						monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		CCCCTTATACCTGTGGGGCCC	0.577000			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							11	51					0	0	1	0	0
FADD	8772	broad.mit.edu	37	11	70049672	70049672	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:70049672T>C	ENST00000301838.4	+	1	404	c.107T>C	c.(106-108)cTg>cCg	p.L36P		NM_003824.3	NP_003815.1	Q13158	FADD_HUMAN	Fas (TNFRSF6)-associated via death domain	36	DED.				activation of caspase activity|activation of pro-apoptotic gene products|cellular response to mechanical stimulus|defense response to virus|induction of apoptosis via death domain receptors|innate immune response|interspecies interaction between organisms|necrotic cell death|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|signal transduction	cytosol	death receptor binding|identical protein binding			endometrium(1)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(2)	9	Esophageal squamous(2;1.19e-45)		LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			AAGCGCAAGCTGGAGCGCGTG	0.672000													14	11					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061902	9061902	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr19:9061902G>A	ENST00000397910.4	-	3	25747	c.25544C>T	c.(25543-25545)tCa>tTa	p.S8515L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8517	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTTGTTGTTGAGGTGTCCAA	0.488000													29	77					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42265515	42265515	+	Silent	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr13:42265515G>A	ENST00000379310.3	-	32	3875	c.3807C>T	c.(3805-3807)ctC>ctT	p.L1269L	VWA8_ENST00000478987.1_5'UTR	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		AAACTGTCTTGAGGTTGATGG	0.433000													20	81					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144942388	144942388	+	Silent	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr8:144942388G>A	ENST00000525985.1	-	2	5105	c.5034C>T	c.(5032-5034)atC>atT	p.I1678I				P58107	EPIPL_HUMAN	epiplakin 1	1678						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCAGCAGGCGGATGCCGTGCT	0.692000													8	57					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44922802	44922802	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chrX:44922802C>T	ENST00000377967.4	+	16	1704	c.1663C>T	c.(1663-1665)Cag>Tag	p.Q555*	KDM6A_ENST00000536777.1_Nonsense_Mutation_p.Q510*|KDM6A_ENST00000543216.1_Nonsense_Mutation_p.Q476*|KDM6A_ENST00000382899.4_Nonsense_Mutation_p.Q562*	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	555					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.0(2)|p.Q555*(2)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TAGCGTCTCTCAGCCTGGAGT	0.567000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								26	1					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	169994004	169994004	+	Splice_Site	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr2:169994004C>G	ENST00000263816.3	-	76	13804		c.e76-1			NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2						hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGTCTTCACTCTGATGGCaga	0.448000													3	46					0	0	1	0	0
INSC	387755	broad.mit.edu	37	11	15243191	15243191	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:15243191G>A	ENST00000379554.3	+	8	1175	c.1129G>A	c.(1129-1131)Gtc>Atc	p.V377I	INSC_ENST00000424273.1_Missense_Mutation_p.V288I|INSC_ENST00000379556.3_Missense_Mutation_p.V330I|INSC_ENST00000530161.1_Missense_Mutation_p.V330I|INSC_ENST00000447214.2_3'UTR|INSC_ENST00000528567.1_Missense_Mutation_p.V330I|INSC_ENST00000525218.1_Missense_Mutation_p.V288I	NM_001031853.3	NP_001027024.3	Q1MX18	INSC_HUMAN	inscuteable homolog (Drosophila)	377					cell differentiation|nervous system development	cytoplasm	binding			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(3)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49						GACAGCCCTCGTCAGTGAGTC	0.617000													15	17					0	0	1	0	0
CLEC1A	51267	broad.mit.edu	37	12	10226003	10226003	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:10226003G>A	ENST00000315330.4	-	5	613	c.551C>T	c.(550-552)gCc>gTc	p.A184V	CLEC1A_ENST00000457018.2_Missense_Mutation_p.A151V|CLEC1A_ENST00000420265.2_Missense_Mutation_p.A92V	NM_016511.2	NP_057595.2	Q8NC01	CLC1A_HUMAN	C-type lectin domain family 1, member A	184	C-type lectin.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	23						CTGAGACGCGGCAAATTCCTG	0.488000													4	81					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70009464	70009464	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:70009464C>T	ENST00000316296.5	+	17	1899	c.1794C>T	c.(1792-1794)ttC>ttT	p.F598F	ANO1_ENST00000398543.2_Intron|ANO1_ENST00000530676.1_Intron|ANO1_ENST00000355303.5_Intron|ANO1_ENST00000531349.1_Intron|ANO1_ENST00000538023.1_Intron			Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	0					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						AAATTTTATTCATCTCTGGCA	0.498000													6	31					0	0	1	0	0
APOC1	341	broad.mit.edu	37	19	45419475	45419475	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr19:45419475C>T	ENST00000588750.1	+	4	412	c.87C>T	c.(85-87)gaC>gaT	p.D29D	APOC1_ENST00000588802.1_Silent_p.D29D|APOC1_ENST00000586638.1_Silent_p.D29D|APOC1_ENST00000252491.4_Silent_p.D29D|APOC1_ENST00000592885.1_Silent_p.D29D|APOC1_ENST00000589781.1_Intron			P02654	APOC1_HUMAN	apolipoprotein C-I	29					cholesterol efflux|chylomicron remnant clearance|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol transport|negative regulation of fatty acid biosynthetic process|negative regulation of lipoprotein lipase activity|negative regulation of phosphatidylcholine catabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of very-low-density lipoprotein particle clearance|phospholipid efflux|positive regulation of cholesterol esterification|very-low-density lipoprotein particle assembly|very-low-density lipoprotein particle clearance	chylomicron|endoplasmic reticulum|high-density lipoprotein particle|very-low-density lipoprotein particle	fatty acid binding|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipase inhibitor activity			cervix(1)|large_intestine(1)|lung(2)	4	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)		GGACCCCAGACGTCTCCAGTG	0.507000													4	59					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49674873	49674873	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr19:49674873C>T	ENST00000252826.5	+	8	1023	c.897C>T	c.(895-897)ctC>ctT	p.L299L	TRPM4_ENST00000427978.2_Silent_p.L299L|TRPM4_ENST00000601347.1_3'UTR|TRPM4_ENST00000355712.5_Silent_p.L16L	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	299					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TCCCATGTCTCCTCGTGGCTG	0.602000													10	27					0	0	1	0	0
CNBD1	168975	broad.mit.edu	37	8	88296917	88296917	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr8:88296917G>C	ENST00000518476.1	+	7	834	c.783G>C	c.(781-783)tgG>tgC	p.W261C	CNBD1_ENST00000522427.1_3'UTR	NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	261										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						TTAGCAAATGGAGTACCTTTG	0.393000													6	13					0	0	1	0	0
EMILIN2	84034	broad.mit.edu	37	18	2891229	2891229	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr18:2891229C>T	ENST00000254528.3	+	4	1263	c.1104C>T	c.(1102-1104)ctC>ctT	p.L368L		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	368					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		TGATAGAGCTCATAGGGGAGA	0.507000													23	31					0	0	1	0	0
ZBTB17	7709	broad.mit.edu	37	1	16268613	16268613	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:16268613G>C	ENST00000375733.2	-	16	2522	c.2284C>G	c.(2284-2286)Cag>Gag	p.Q762E	ZBTB17_ENST00000537142.1_Missense_Mutation_p.Q673E|ZBTB17_ENST00000375743.4_Missense_Mutation_p.Q755E			Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	755	Interaction with HCFC1.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)	15		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		CCATACTGCTGATAGAAGTCC	0.647000													4	51					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11963917	11963917	+	Translation_Start_Site	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:11963917G>A	ENST00000539466.1	+	0	2560				USP47_ENST00000399455.2_Silent_p.Q803Q|USP47_ENST00000527733.1_Silent_p.Q783Q|USP47_ENST00000339865.5_Silent_p.Q715Q			Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47						base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		TGGATTACCAGATGGCCTTTG	0.358000													17	115					0	0	1	0	0
POLR3A	11128	broad.mit.edu	37	10	79743752	79743752	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr10:79743752C>A	ENST00000372371.3	-	26	3492	c.3355G>T	c.(3355-3357)Gaa>Taa	p.E1119*		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	1119					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			AGAAACACTTCTTCAATATAC	0.428000													6	22					0.00198382	0.00204486	1	1	0
MMP27	64066	broad.mit.edu	37	11	102576410	102576410	+	Silent	SNP	T	T	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:102576410T>A	ENST00000260229.4	-	1	127	c.36A>T	c.(34-36)atA>atT	p.I12I		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	12					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		AAGAAAATGTTATAAAGAACA	0.378000													27	41					0	0	1	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135772879	135772879	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chrX:135772879G>C	ENST00000250617.6	-	10	2280	c.1075C>G	c.(1075-1077)Caa>Gaa	p.Q359E	ARHGEF6_ENST00000370622.1_Missense_Mutation_p.Q205E|ARHGEF6_ENST00000370620.1_Missense_Mutation_p.Q205E|ARHGEF6_ENST00000535227.1_Missense_Mutation_p.Q232E	NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	359	DH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.Q359E(1)		cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					GATGCACCTTGATTTTCCATG	0.343000													10	33					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65621842	65621842	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr15:65621842C>T	ENST00000327987.4	-	13	2342	c.2091G>A	c.(2089-2091)gcG>gcA	p.A697A		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	697										breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GTCCCCGTCTCGCCCCATTTA	0.647000													15	49					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159554615	159554615	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr4:159554615G>C	ENST00000307765.5	+	12	1209	c.958G>C	c.(958-960)Gag>Cag	p.E320Q	RXFP1_ENST00000448688.2_Missense_Mutation_p.E215Q|RXFP1_ENST00000460056.2_Missense_Mutation_p.E239Q|RXFP1_ENST00000470033.1_Missense_Mutation_p.E287Q|RXFP1_ENST00000343542.5_Intron	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	320						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		GGACCTGAAGGAGCTGTCACA	0.284000													4	81					0	0	1	0	0
ARMC8	25852	broad.mit.edu	37	3	137964062	137964062	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr3:137964062G>A	ENST00000358441.2	+	13	1514	c.1129G>A	c.(1129-1131)Gcc>Acc	p.A377T	ARMC8_ENST00000471453.1_Missense_Mutation_p.A377T|ARMC8_ENST00000538260.1_Intron|ARMC8_ENST00000461822.1_Intron|ARMC8_ENST00000485396.1_Intron|ARMC8_ENST00000491704.1_Intron|ARMC8_ENST00000489213.1_Missense_Mutation_p.A349T|ARMC8_ENST00000469044.1_Intron|ARMC8_ENST00000481646.1_Intron|ARMC8_ENST00000393058.3_Intron|ARMC8_ENST00000470821.1_Missense_Mutation_p.A391T	NM_014154.3|NM_213654.2	NP_054873.2|NP_998819.1	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8	0							binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(5)|upper_aerodigestive_tract(1)	16						AGTCCTGACAGCCAGCAGGCA	0.507000													3	45					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52883557	52883557	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr4:52883557G>A	ENST00000343457.3	-	1	229	c.223C>T	c.(223-225)Ctc>Ttc	p.L75F		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	75						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						GACTGTAAGAGAACTCTAAAG	0.353000													7	61					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr4:1803568C>G	ENST00000340107.4	+	7	1002	c.746C>G	c.(745-747)tCc>tGc	p.S249C	FGFR3_ENST00000412135.2_Missense_Mutation_p.S249C|FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000481110.2_Missense_Mutation_p.S249C|FGFR3_ENST00000352904.1_Missense_Mutation_p.S249C|FGFR3_ENST00000440486.2_Missense_Mutation_p.S249C|FGFR3_ENST00000260795.2_Missense_Mutation_p.S249C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	249			S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1204)|p.R248_S249del(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.736000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				8	9					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33359047	33359047	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr15:33359047G>C	ENST00000334528.9	-	1	1038	c.1039C>G	c.(1039-1041)Ctg>Gtg	p.L347V	FMN1_ENST00000558197.1_Missense_Mutation_p.L347V|FMN1_ENST00000561249.1_Intron|FMN1_ENST00000559150.1_Intron|FMN1_ENST00000559047.1_Intron	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	441	Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TTGAGCAGCAGAGAGAGCTGC	0.552000													12	75					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27730583	27730583	+	Silent	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr2:27730583G>C	ENST00000264717.2	+	14	1242	c.1179G>C	c.(1177-1179)ctG>ctC	p.L393L	GCKR_ENST00000424318.2_Silent_p.L203L	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	393	SIS 2.			L -> P (in Ref. 1; CAA88367).	carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					AGGACTTCCTGACTTCCATCC	0.552000													29	75					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302775	145302775	+	Missense_Mutation	SNP	T	T	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:145302775T>G	ENST00000342960.5	+	8	1248	c.1213T>G	c.(1213-1215)Tat>Gat	p.Y405D	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Missense_Mutation_p.Y134D|NBPF10_ENST00000369339.3_Missense_Mutation_p.Y134D	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	405										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CCTCACTCCGTATGAGCCGGA	0.577000													4	160					0	0	1	0	0
SPNS1	83985	broad.mit.edu	37	16	28989300	28989300	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr16:28989300C>G	ENST00000311008.11	+	3	756	c.379C>G	c.(379-381)Ctc>Gtc	p.L127V	SPNS1_ENST00000565975.1_Missense_Mutation_p.L172V|SPNS1_ENST00000561868.1_Intron|SPNS1_ENST00000352260.7_Missense_Mutation_p.L105V|RP11-264B17.3_ENST00000569969.1_RNA|SPNS1_ENST00000334536.8_Missense_Mutation_p.L127V|RP11-264B17.4_ENST00000567209.1_RNA|SPNS1_ENST00000323081.8_Missense_Mutation_p.L54V	NM_032038.2	NP_114427.1	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 (Drosophila)	127					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)|urinary_tract(1)	21						TCGGAAGTATCTCATGTGCGG	0.567000											OREG0023711	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	33					0	0	1	0	0
OVCH2	341277	broad.mit.edu	37	11	7725246	7725246	+	RNA	SNP	T	T	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:7725246T>A	ENST00000454689.1	-	0	288				OVCH2_ENST00000534193.2_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		CTTTCTTACCTGTTTGCAATG	0.463000													3	7					0	0	1	0	0
MS4A10	341116	broad.mit.edu	37	11	60565962	60565962	+	Missense_Mutation	SNP	G	G	A	rs146236803	byFrequency	TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:60565962G>A	ENST00000308287.1	+	7	793	c.697G>A	c.(697-699)Gac>Aac	p.D233N		NM_206893.3	NP_996776.2	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member 10	233						integral to membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|skin(2)	21						GATTCAAGGCGACGCACAACA	0.547000													14	17					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63538806	63538806	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr7:63538806C>G	ENST00000550760.3	+	4	1558	c.1379C>G	c.(1378-1380)aCc>aGc	p.T460S		NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						TGTGGCAAAACCTTTACCTGC	0.428000													3	19					0	0	1	0	0
ZCCHC8	55596	broad.mit.edu	37	12	122966628	122966628	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:122966628T>A	ENST00000543897.1	-	7	2380	c.25A>T	c.(25-27)Aat>Tat	p.N9Y	ZCCHC8_ENST00000536306.1_Missense_Mutation_p.N9Y|ZCCHC8_ENST00000336229.4_Missense_Mutation_p.N247Y			Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	247						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		CGAGCAGCATTCCGAGGCTAC	0.348000													20	40					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41012715	41012715	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr5:41012715C>T	ENST00000399564.4	-	30	3555	c.3105G>A	c.(3103-3105)ctG>ctA	p.L1035L	MROH2B_ENST00000506092.2_Silent_p.L590L	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CCTGCTGCTTCAGGACAGTGA	0.463000													12	50					0	0	1	0	0
MIEN1	84299	broad.mit.edu	37	17	37885811	37885811	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:37885811C>G	ENST00000394231.3	-	4	603	c.312G>C	c.(310-312)aaG>aaC	p.K104N	MIEN1_ENST00000474210.1_5'UTR|ERBB2_ENST00000584888.1_Intron|MIEN1_ENST00000577810.1_3'UTR			Q9BRT3	CQ037_HUMAN	migration and invasion enhancer 1	104					cell redox homeostasis	cytosol|membrane	selenium binding										TGTTGGTGATCTTTTCTAGGG	0.542000													19	97					0	0	1	0	0
NPTN	27020	broad.mit.edu	37	15	73862604	73862604	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr15:73862604C>T	ENST00000351217.6	-	5	1571	c.653G>A	c.(652-654)cGg>cAg	p.R218Q	NPTN_ENST00000287226.8_Missense_Mutation_p.G318R|NPTN_ENST00000563691.1_Missense_Mutation_p.R334Q|NPTN_ENST00000542234.1_Missense_Mutation_p.R129Q|NPTN_ENST00000545878.1_Missense_Mutation_p.R334Q|NPTN_ENST00000562924.1_Missense_Mutation_p.R218Q|NPTN_ENST00000345330.4_Missense_Mutation_p.R334Q	NM_001161364.1|NM_017455.3	NP_001154836.1|NP_059429.1	Q9Y639	NPTN_HUMAN	neuroplastin	334	Ig-like 2.				elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	13						CAGGTGGCTCCGCACCCTGAG	0.517000													4	55					0	0	1	0	0
EDN3	1908	broad.mit.edu	37	20	57876522	57876522	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr20:57876522C>G	ENST00000311585.7	+	2	480	c.110C>G	c.(109-111)cCc>cGc	p.P37R	EDN3_ENST00000337938.2_Missense_Mutation_p.P37R|EDN3_ENST00000371025.3_Missense_Mutation_p.P37R|EDN3_ENST00000395654.3_Missense_Mutation_p.P37R|EDN3_ENST00000371028.2_Missense_Mutation_p.P37R	NM_207032.1	NP_996915.1	P14138	EDN3_HUMAN	endothelin 3	37					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	19	all_lung(29;0.0115)					TCCCAGGCCCCCACTGCAGCC	0.657000													15	26					0	0	1	0	0
OR6C1	390321	broad.mit.edu	37	12	55714585	55714585	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:55714585G>C	ENST00000379668.2	+	1	240	c.202G>C	c.(202-204)Gaa>Caa	p.E68Q		NM_001005182.1	NP_001005182.1	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C, member 1	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|liver(2)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	25						CTCCATATTAGAAATTTCGTT	0.393000													7	36					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16681566	16681566	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr5:16681566C>T	ENST00000513610.1	-	32	4690	c.4236G>A	c.(4234-4236)ctG>ctA	p.L1412L	MYO10_ENST00000515803.1_Silent_p.L751L|MYO10_ENST00000427430.2_Silent_p.L769L|MYO10_ENST00000505695.1_Silent_p.L751L|MYO10_ENST00000274203.9_Silent_p.L769L	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1412	PH 2.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						TCTTCAGTTTCAGTGAAGACA	0.428000													46	73					0	0	1	0	0
TMEM26	219623	broad.mit.edu	37	10	63212714	63212714	+	Silent	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr10:63212714G>A	ENST00000399298.3	-	1	494	c.126C>T	c.(124-126)ctC>ctT	p.L42L	RP11-809M12.1_ENST00000389640.4_RNA|TMEM26_ENST00000399293.1_Silent_p.L42L	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	42						integral to membrane				kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	18	Prostate(12;0.0112)					GCAAGAGGTTGAGCAGCGCAA	0.642000													18	63					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61831602	61831602	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr10:61831602C>G	ENST00000280772.2	-	37	9228	c.9037G>C	c.(9037-9039)Gaa>Caa	p.E3013Q	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTTCATCTTCTATAGAATTA	0.403000													18	82					0	0	1	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213341296	213341296	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:213341296C>G	ENST00000366960.3	+	7	1081	c.931C>G	c.(931-933)Cag>Gag	p.Q311E	RPS6KC1_ENST00000490299.1_3'UTR|RPS6KC1_ENST00000543354.1_Missense_Mutation_p.Q14E|RPS6KC1_ENST00000366959.3_Missense_Mutation_p.Q299E|RPS6KC1_ENST00000543470.1_Missense_Mutation_p.Q130E	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	311					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TGGGAAACCTCAGCTTGATGA	0.418000													17	47					0	0	1	0	0
GCA	25801	broad.mit.edu	37	2	163204191	163204191	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr2:163204191C>A	ENST00000437150.2	+	2	292	c.131C>A	c.(130-132)tCa>tAa	p.S44*	GCA_ENST00000473240.1_3'UTR|GCA_ENST00000429691.2_Nonsense_Mutation_p.S25*|GCA_ENST00000233612.4_Nonsense_Mutation_p.S25*	NM_012198.3	NP_036330.1	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	44					cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(1)	9						CCAGCATATTCAGACACTTAT	0.448000													15	30					7.93312e-07	8.30499e-07	1	1	0
BRCA1	672	broad.mit.edu	37	17	41246791	41246791	+	Missense_Mutation	SNP	C	C	T	rs80357293		TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:41246791C>T	ENST00000357654.3	-	10	875	c.757G>A	c.(757-759)Gca>Aca	p.A253T	BRCA1_ENST00000491747.2_Missense_Mutation_p.A253T|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000471181.2_Missense_Mutation_p.A253T|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000309486.4_5'UTR|BRCA1_ENST00000468300.1_Missense_Mutation_p.A253T|BRCA1_ENST00000493795.1_Missense_Mutation_p.A206T|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000346315.3_Missense_Mutation_p.A253T|BRCA1_ENST00000354071.3_Missense_Mutation_p.A253T|BRCA1_ENST00000351666.3_Intron	NM_007294.3	NP_009225.1	P38398	BRCA1_HUMAN	breast cancer 1, early onset	253				A -> V (in Ref. 3; AAC00049).	androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CTCTCAGCTGCACGCTTCTCA	0.413000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			23	36					0	0	1	0	0
MAP2K2	5605	broad.mit.edu	37	19	4110556	4110556	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr19:4110556T>C	ENST00000262948.5	-	3	654	c.401A>G	c.(400-402)tAc>tGc	p.Y134C	MAP2K2_ENST00000394867.4_Missense_Mutation_p.Y37C|MAP2K2_ENST00000599345.1_5'UTR	NM_030662.3	NP_109587.1	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	134	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGGCCCCGTAGAAGCCCAC	0.612000													9	40					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144943216	144943216	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr8:144943216G>T	ENST00000525985.1	-	2	4277	c.4206C>A	c.(4204-4206)ttC>ttA	p.F1402L				P58107	EPIPL_HUMAN	epiplakin 1	1402						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTCAAAGAAGAACTTGTTGT	0.627000													3	21					0.150653	0.152168	1	1	0
ZNF695	57116	broad.mit.edu	37	1	247151032	247151032	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:247151032T>A	ENST00000339986.7	-	4	932	c.785A>T	c.(784-786)cAt>cTt	p.H262L	ZNF695_ENST00000498046.2_Intron|ZNF695_ENST00000487338.2_Intron	NM_020394.4	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein 695	262					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTTTTCAGTATGATTTTTCTC	0.338000													9	15					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17697755	17697755	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:17697755C>G	ENST00000353383.1	+	3	1962	c.1493C>G	c.(1492-1494)tCa>tGa	p.S498*	RAI1_ENST00000261641.6_Nonsense_Mutation_p.S498*	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	498						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		ACACCGCTGTCAGAGCCGCCG	0.667000													4	30					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71197331	71197331	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr14:71197331C>G	ENST00000554752.2	-	12	3080	c.3081G>C	c.(3079-3081)gaG>gaC	p.E1027D	MAP3K9_ENST00000553414.1_Missense_Mutation_p.E760D|MAP3K9_ENST00000554146.1_Missense_Mutation_p.E755D|MAP3K9_ENST00000555993.2_Missense_Mutation_p.E1041D|MAP3K9_ENST00000381250.4_Missense_Mutation_p.E1004D	NM_001284230.1	NP_001271159.1	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	1027	Ser-rich.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TGCTGGGCGTCTCTGTGCTGG	0.662000													5	53					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2733516	2733516	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr4:2733516C>T	ENST00000324666.5	+	20	4070	c.3719C>T	c.(3718-3720)tCt>tTt	p.S1240F	FAM193A_ENST00000505311.1_3'UTR|FAM193A_ENST00000382839.3_Missense_Mutation_p.S1199F|FAM193A_ENST00000502458.1_Missense_Mutation_p.S1221F	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	1240										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						TGCTTGGATTCTGCTAGACAG	0.493000													52	133					0	0	1	0	0
KRT33A	3883	broad.mit.edu	37	17	39502859	39502859	+	Missense_Mutation	SNP	T	T	A	rs144592837		TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr17:39502859T>A	ENST00000007735.3	-	6	982	c.938A>T	c.(937-939)cAg>cTg	p.Q313L		NM_004138.3	NP_004129.2	O76009	KT33A_HUMAN	keratin 33A	313	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	21		Breast(137;0.000496)				TCTCTGCACCTGGGACAGCTG	0.612000													16	32					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43547627	43547627	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr7:43547627C>T	ENST00000395891.2	+	23	4368	c.3763C>T	c.(3763-3765)Cgc>Tgc	p.R1255C	HECW1_ENST00000453890.1_Missense_Mutation_p.R1221C	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						GCTCATTATTCGCCGGGATCA	0.517000													4	64					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40359794	40359794	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr6:40359794G>A	ENST00000338305.6	-	3	2800	c.2258C>T	c.(2257-2259)aCg>aTg	p.T753M		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	753						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCTGCGCTTCGTCCAGATGTT	0.647000													21	17					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79733567	79733567	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr5:79733567G>A	ENST00000338008.5	+	3	1243	c.1063G>A	c.(1063-1065)Gat>Aat	p.D355N	ZFYVE16_ENST00000505560.1_Missense_Mutation_p.D355N|ZFYVE16_ENST00000510158.1_Missense_Mutation_p.D355N	NM_001284236.1|NM_014733.3	NP_001271165.1|NP_055548	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	355					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TAAGGATAATGATGTAATCCA	0.373000													25	73					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53237935	53237935	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:53237935G>C	ENST00000359499.4	-	6	670	c.659C>G	c.(658-660)tCt>tGt	p.S220C	KRT78_ENST00000304620.4_Missense_Mutation_p.S330C			Q8N1N4	K2C78_HUMAN	keratin 78	330	Coil 1B.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						GTGTAGCTGAGAGATCTGGAC	0.517000													17	122					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40980878	40980878	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr20:40980878C>T	ENST00000373198.4	-	10	1843	c.1608G>A	c.(1606-1608)tcG>tcA	p.S536S	PTPRT_ENST00000373187.1_Silent_p.S536S|PTPRT_ENST00000356100.2_Silent_p.S536S|PTPRT_ENST00000373184.1_Silent_p.S536S|PTPRT_ENST00000373190.1_Silent_p.S536S|PTPRT_ENST00000373201.1_Silent_p.S536S|PTPRT_ENST00000373193.3_Silent_p.S536S	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T		Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCCTCTGGCTCGAGAGGTCAG	0.527000													33	39					0	0	1	0	0
BAG6	7917	broad.mit.edu	37	6	31608053	31608053	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr6:31608053G>A	ENST00000404765.2	-	24	3458	c.3169C>T	c.(3169-3171)Cag>Tag	p.Q1057*	BAG6_ENST00000439687.2_Nonsense_Mutation_p.Q847*|BAG6_ENST00000375976.4_Nonsense_Mutation_p.Q1021*|BAG6_ENST00000362049.6_Nonsense_Mutation_p.Q1021*|BAG6_ENST00000211379.5_Nonsense_Mutation_p.Q1021*|BAG6_ENST00000375964.6_Nonsense_Mutation_p.Q1027*			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	1027					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						CGCTGGCTCTGAATGTCCTGC	0.517000													7	63					0	0	1	0	0
NOP56	10528	broad.mit.edu	37	20	2638639	2638639	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr20:2638639G>C	ENST00000329276.5	+	12	2000	c.1484G>C	c.(1483-1485)gGa>gCa	p.G495A	NOP56_ENST00000492135.1_3'UTR	NM_006392.3	NP_006383.2	O00567	NOP56_HUMAN	NOP56 ribonucleoprotein	495	Lys-rich.				rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25						CAGGAGAATGGAATGGAAGAC	0.458000													22	101					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237838083	237838083	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:237838083T>A	ENST00000366574.2	+	60	9084	c.8767T>A	c.(8767-8769)Tat>Aat	p.Y2923N	RYR2_ENST00000360064.6_Missense_Mutation_p.Y2921N|RYR2_ENST00000609119.1_3'UTR|RYR2_ENST00000542537.1_Missense_Mutation_p.Y2907N	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2923	4 X approximate repeats.|Modulator (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACGATTTGCCTATAGTTTCCT	0.428000													10	19					0	0	1	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100801782	100801782	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr15:100801782C>T	ENST00000268070.4	-	6	1038	c.933G>A	c.(931-933)caG>caA	p.Q311Q		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	311	Peptidase M12B.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		ACTCCTCGTTCTGCCAGTGAC	0.567000													6	14					0	0	1	0	0
TP73-AS1	57212	broad.mit.edu	37	1	3662658	3662658	+	RNA	SNP	G	G	A			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:3662658G>A	ENST00000452079.1	-	0	1228				TP73-AS1_ENST00000423764.1_RNA|TP73-AS1_ENST00000544565.1_RNA|TP73-AS1_ENST00000418088.1_RNA	NR_033711.1																						GGGACTGCCTGAGAGAATGAG	0.647000													6	75					0	0	1	0	0
PRKRIR	5612	broad.mit.edu	37	11	76072096	76072096	+	Silent	SNP	C	C	T			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr11:76072096C>T	ENST00000260045.3	-	3	327	c.222G>A	c.(220-222)agG>agA	p.R74R	PRKRIR_ENST00000531878.1_5'UTR	NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	74					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						GAAGAACTGTCCTATAAGGAC	0.308000													4	46					0	0	1	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154988201	154988201	+	Frame_Shift_Del	DEL	C	C	-			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr1:154988201delC	ENST00000368426.3	+	3	1202	c.1065delC	c.(1063-1065)atcfs	p.I355fs	ZBTB7B_ENST00000292176.2_Frame_Shift_Del_p.I355fs|ZBTB7B_ENST00000417934.2_Frame_Shift_Del_p.I389fs|ZBTB7B_ENST00000535420.1_Frame_Shift_Del_p.I355fs	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	355					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ACAAGATCATCCATGGGGCAG	0.612													29	51	---	---	---	---					
BOD1	91272	broad.mit.edu	37	5	173043417	173043419	+	In_Frame_Del	DEL	CCG	CCG	-			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr5:173043417_173043419delCCG	ENST00000311086.4	-	1	244_246	c.21_23delCGG	c.(19-24)ggcggg>ggg	p.7_8GG>G	BOD1_ENST00000471339.1_5'UTR|BOD1_ENST00000285908.5_In_Frame_Del_p.7_8GG>G|BOD1_ENST00000480951.1_In_Frame_Del_p.7_8GG>G	NM_138369.2	NP_612378.1	Q96IK1	BOD1_HUMAN	biorientation of chromosomes in cell division 1	7	Gly-rich.				cell division|mitosis	condensed chromosome kinetochore|microtubule organizing center				endometrium(1)|large_intestine(2)|lung(2)|ovary(2)	7						GCCAGTTCCCCCGCCGCCGCCGC	0.714													2	4	---	---	---	---					
CD274	29126	broad.mit.edu	37	9	5463001	5463002	+	Frame_Shift_Ins	INS	-	-	TTCA			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr9:5463001_5463002insTTCA	ENST00000381577.3	+	4	648_649	c.562_563insTTCA	c.(562-564)gagfs	p.E188fs	CD274_ENST00000498261.1_Intron|CD274_ENST00000381573.4_Frame_Shift_Ins_p.E74fs	NM_014143.3	NP_054862.1	Q9NZQ7	PD1L1_HUMAN	CD274 molecule	188	Ig-like C2-type.				cell proliferation|cell surface receptor linked signaling pathway|immune response|T cell costimulation	endomembrane system|integral to membrane	receptor activity	p.E188K(1)		central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	11	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000742)|Lung(218;0.111)		CAAGAGAGAGGAGAAGCTTTTC	0.460			T	CIITA	"""PMBL, Hodgkin Lymphona, """								20	57	---	---	---	---					
OR6C65	403282	broad.mit.edu	37	12	55794610	55794610	+	Frame_Shift_Del	DEL	T	T	-			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr12:55794610delT	ENST00000379665.2	+	1	397	c.298delT	c.(298-300)tttfs	p.F101fs		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L102fs*1(1)		cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						GGCCCAAGTATTTTTTTTAAT	0.358													51	96	---	---	---	---					
IRF9	10379	broad.mit.edu	37	14	24633132	24633134	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-4Z-AA89-01A-11D-A391-08	TCGA-4Z-AA89-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1468d6c1-89d9-4cf4-a37f-4b967a6c5a48	3edca69b-b497-499d-b325-bd6f9e15e57f	g.chr14:24633132_24633134delAGC	ENST00000396864.3	+	5	828_830	c.541_543delAGC	c.(541-543)agcdel	p.S187del	RP11-468E2.4_ENST00000558468.1_3'UTR|IRF9_ENST00000557894.1_In_Frame_Del_p.S85del	NM_006084.4	NP_006075.3	Q00978	IRF9_HUMAN	interferon regulatory factor 9	187	Poly-Ser.				interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16				GBM - Glioblastoma multiforme(265;0.00853)		AGACATTGGGagcagcagcagca	0.567													7	45	---	---	---	---					
