Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
METAP1	23173	broad.mit.edu	37	4	99982412	99982412	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:99982412G>C	ENST00000296411.6	+	11	1239	c.1105G>C	c.(1105-1107)Gaa>Caa	p.E369Q	METAP1_ENST00000544031.1_Missense_Mutation_p.E319Q	NM_015143.2	NP_055958.2	P53582	AMPM1_HUMAN	methionyl aminopeptidase 1	369					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis|regulation of translation	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity|protein binding	p.E369Q(1)		endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17				OV - Ovarian serous cystadenocarcinoma(123;3.12e-07)		CACTGGCTGTGAAATCCTAAC	0.512000													25	59					0	0	0.076483	0	0
SLC4A8	9498	broad.mit.edu	37	12	51868160	51868160	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr12:51868160C>T	ENST00000453097.2	+	15	2156	c.1939C>T	c.(1939-1941)Cac>Tac	p.H647Y	SLC4A8_ENST00000394856.1_Missense_Mutation_p.H594Y|SLC4A8_ENST00000535225.2_Missense_Mutation_p.H594Y|SLC4A8_ENST00000358657.3_Missense_Mutation_p.H674Y|SLC4A8_ENST00000514353.3_Missense_Mutation_p.H594Y	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	647					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity	p.H647Y(2)|p.H594Y(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		TCCAAACAATCACACCCTCCA	0.458000													9	30					0	0	0.047766	0	0
H3F3A	3020	broad.mit.edu	37	1	226252162	226252162	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:226252162A>G	ENST00000366814.3	+	2	231	c.110A>G	c.(109-111)aAg>aGg	p.K37R	H3F3A_ENST00000366816.1_Missense_Mutation_p.K37R|H3F3A_ENST00000366815.3_Missense_Mutation_p.K37R|H3F3A_ENST00000366813.1_Missense_Mutation_p.K37R					H3 histone, family 3A									p.K37R(1)		central_nervous_system(116)|endometrium(2)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	123	Breast(184;0.179)			GBM - Glioblastoma multiforme(131;0.203)		GGAGGGGTGAAGAAACCTCAT	0.448000			Mis		glioma						OREG0014293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	28					0	0	0.047766	0	0
HTRA3	94031	broad.mit.edu	37	4	8288305	8288305	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:8288305G>A	ENST00000307358.2	+	3	707	c.503G>A	c.(502-504)cGc>cAc	p.R168H	HTRA3_ENST00000382512.3_Missense_Mutation_p.R168H	NM_053044.3	NP_444272.1	P83110	HTRA3_HUMAN	HtrA serine peptidase 3	168					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity	p.R168H(1)		central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|prostate(1)|urinary_tract(1)	18						CTGTTTGGCCGCAACGTGCCC	0.662000													16	64					0	0	0.043863	0	0
GTF3C3	9330	broad.mit.edu	37	2	197639909	197639909	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:197639909G>C	ENST00000263956.3	-	13	1851	c.1762C>G	c.(1762-1764)Ctt>Gtt	p.L588V		NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	588						transcription factor TFIIIC complex	DNA binding|protein binding	p.L588V(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						ACTTTAATAAGATAAAGATGC	0.333000													14	37					0	0	0.024245	0	0
FRG1B	284802	broad.mit.edu	37	20	29625947	29625947	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr20:29625947T>C	ENST00000278882.3	+	5	571	c.191T>C	c.(190-192)aTt>aCt	p.I64T	FRG1B_ENST00000439954.2_Missense_Mutation_p.I69T|FRG1B_ENST00000358464.4_Missense_Mutation_p.I64T														p.I64T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCAGATGCAATTGGACCAAGA	0.343000													8	79					0	0	0.058154	0	0
PTPN7	5778	broad.mit.edu	37	1	202124738	202124738	+	Splice_Site	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:202124738C>T	ENST00000309017.3	-	5	1480		c.e5-1		PTPN7_ENST00000492977.1_Splice_Site|PTPN7_ENST00000367279.4_Splice_Site|PTPN7_ENST00000543735.1_Splice_Site|PTPN7_ENST00000544762.1_Intron|PTPN7_ENST00000308986.5_Splice_Site	NM_001199797.1|NM_002832.3	NP_001186726.1|NP_002823.3	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type 7							cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity	p.?(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|soft_tissue(1)|urinary_tract(1)	13						CTCTGGGGATCTAGGAAATAA	0.527000													7	20					0	0	0.047766	0	0
EPN2	22905	broad.mit.edu	37	17	19216560	19216560	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:19216560C>A	ENST00000314728.5	+	7	1599	c.1115C>A	c.(1114-1116)cCt>cAt	p.P372H	EPN2_ENST00000575595.1_Missense_Mutation_p.P80H|EPN2_ENST00000571254.1_Missense_Mutation_p.P308H|EPN2_ENST00000347697.2_Missense_Mutation_p.P315H|EPN2_ENST00000395620.2_Missense_Mutation_p.P315H|EPN2_ENST00000395626.1_Missense_Mutation_p.P372H|EPN2_ENST00000395618.3_Missense_Mutation_p.P87H	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	372	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding	p.P372H(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CCAGCGGCTCCTGCGAGTACT	0.657000													141	277					2.0701e-58	2.20131e-58	0.048971	1	0
RASGEF1A	221002	broad.mit.edu	37	10	43701441	43701441	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:43701441C>T	ENST00000395809.1	-	2	2630	c.124G>A	c.(124-126)Gat>Aat	p.D42N	RASGEF1A_ENST00000395810.1_Missense_Mutation_p.D42N|RASGEF1A_ENST00000374459.1_Missense_Mutation_p.D50N			Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	42	N-terminal Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity	p.D42N(1)		cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)	11						AGGTGTCCATCTTGGAAGATG	0.647000													10	12					0	0	0.058154	0	0
GGCX	2677	broad.mit.edu	37	2	85785670	85785670	+	Silent	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:85785670C>T	ENST00000233838.4	-	4	512	c.432G>A	c.(430-432)ctG>ctA	p.L144L	GGCX_ENST00000430215.3_Silent_p.L87L	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase						blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity	p.L144L(1)		endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	ACCAGTATGGCAGCAGGAATA	0.493000													24	44					0	0	0.076483	0	0
DOCK3	1795	broad.mit.edu	37	3	51393912	51393912	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:51393912G>C	ENST00000266037.9	+	43	4514	c.4491G>C	c.(4489-4491)gaG>gaC	p.E1497D		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1497	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding	p.E1497D(1)|p.E1486D(1)		breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TTGAAGTGGAGAGGAGGGAAC	0.542000													16	47					0	0	0.028581	0	0
ZNF573	126231	broad.mit.edu	37	19	38229523	38229523	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:38229523G>C	ENST00000339503.4	-	8	2195	c.1694C>G	c.(1693-1695)tCa>tGa	p.S565*	ZNF573_ENST00000536220.1_Nonsense_Mutation_p.S535*|ZNF573_ENST00000392138.1_Nonsense_Mutation_p.S536*|ZNF573_ENST00000357309.3_Nonsense_Mutation_p.S535*|ZNF573_ENST00000590414.2_Nonsense_Mutation_p.S623*	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	603					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S565*(1)		NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			AACAAGGTTTGAAGCACGACT	0.413000													46	77					0	0	0.042209	0	0
UFSP2	55325	broad.mit.edu	37	4	186334999	186334999	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:186334999G>T	ENST00000264689.6	-	7	828	c.712C>A	c.(712-714)Cac>Aac	p.H238N		NM_018359.3	NP_060829.2	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	238						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity	p.H238N(1)		endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		GGTCTGTCGTGAGGCAGATTG	0.333000													26	31					1.1804e-14	1.22924e-14	0.091800	1	0
IQGAP3	128239	broad.mit.edu	37	1	156503868	156503868	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:156503868G>C	ENST00000361170.2	-	30	3816	c.3806C>G	c.(3805-3807)tCa>tGa	p.S1269*		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1269					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity	p.S1269*(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CACCATGTCTGAGTACTCGTC	0.607000													26	47					0	0	0.030593	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25168432	25168432	+	RNA	SNP	T	T	C	rs149337771	by1000genomes	TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr13:25168432T>C	ENST00000453498.1	+	0	1104				TPTE2P6_ENST00000440905.1_RNA																							TTGAAACAGCTGGTGTATTAA	0.373000													3	23					0	0	0.014758	0	0
CDC14A	8556	broad.mit.edu	37	1	100920981	100920981	+	Silent	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:100920981C>T	ENST00000336454.3	+	8	895	c.540C>T	c.(538-540)ttC>ttT	p.F180F	CDC14A_ENST00000361544.6_Silent_p.F180F|CDC14A_ENST00000370125.2_Intron|CDC14A_ENST00000544534.1_Silent_p.F180F|CDC14A_ENST00000370124.3_Silent_p.F180F|CDC14A_ENST00000542213.1_Silent_p.F122F	NM_003672.3	NP_003663.2	Q9UNH5	CC14A_HUMAN	cell division cycle 14A	180	B.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.F180F(1)		breast(1)|endometrium(5)|kidney(6)|large_intestine(6)|lung(10)|skin(2)|urinary_tract(1)	31		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		ATGGTGACTTCAACTGGATTG	0.303000													27	38					0	0	0.108266	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55329821	55329821	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:55329821G>A	ENST00000391728.4	+	3	155	c.122G>A	c.(121-123)cGa>cAa	p.R41Q	KIR3DL1_ENST00000541392.1_Missense_Mutation_p.R41Q|KIR3DL1_ENST00000358178.4_Intron|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.R41Q|KIR3DL1_ENST00000538269.1_Missense_Mutation_p.R41Q|KIR3DL1_ENST00000326542.7_Missense_Mutation_p.R41Q	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1									p.R41Q(2)		breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		GTGGTGCCTCGAGGAGGACAC	0.542000													37	54					0	0	0.098360	0	0
ZNF516	9658	broad.mit.edu	37	18	74091604	74091604	+	Silent	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr18:74091604G>A	ENST00000443185.2	-	4	2783	c.2466C>T	c.(2464-2466)ctC>ctT	p.L822L	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	822					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.L822L(1)		central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CTTTGCCACCGAGGGCAGGCG	0.622000													31	72					0	0	0.041601	0	0
B3GAT2	135152	broad.mit.edu	37	6	71665793	71665793	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:71665793T>C	ENST00000230053.6	-	1	948	c.340A>G	c.(340-342)Atc>Gtc	p.I114V		NM_080742.2	NP_542780.1	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)	114					carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding	p.I114V(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						TCCACCAGGATCCAGTGCAGC	0.721000													5	10					0	0	0.021553	0	0
TTN	7273	broad.mit.edu	37	2	179638034	179638034	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:179638034C>G	ENST00000589042.1	-	33	7881	c.7657G>C	c.(7657-7659)Gag>Cag	p.E2553Q	TTN_ENST00000342992.6_Missense_Mutation_p.E2553Q|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000584485.1_RNA|TTN_ENST00000360870.5_Missense_Mutation_p.E2553Q|TTN-AS1_ENST00000610005.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E2507Q|TTN_ENST00000460472.2_Missense_Mutation_p.E2507Q|TTN_ENST00000342175.6_Missense_Mutation_p.E2507Q|TTN_ENST00000591111.1_Missense_Mutation_p.E2553Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2287							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E2507Q(3)|p.E2553Q(3)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCTCAACCTCAAACACCACA	0.353000													18	33					0	0	0.049695	0	0
BEST1	7439	broad.mit.edu	37	11	61727388	61727388	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:61727388A>G	ENST00000449131.2	+	8	879	c.793A>G	c.(793-795)Atg>Gtg	p.M265V	BEST1_ENST00000301774.9_Intron|FTH1_ENST00000529191.1_Silent_p.H42H|BEST1_ENST00000378042.3_Missense_Mutation_p.M238V|BEST1_ENST00000378043.4_Missense_Mutation_p.M325V|BEST1_ENST00000526988.1_Silent_p.R286R|BEST1_ENST00000534553.1_Intron|BEST1_ENST00000435278.2_Intron|FTH1_ENST00000529631.1_Intron	NM_001139443.1	NP_001132915.1	O76090	BEST1_HUMAN	bestrophin 1	325					response to stimulus|transepithelial chloride transport|visual perception	basolateral plasma membrane|chloride channel complex|cytosol|membrane fraction	chloride channel activity	p.M265V(1)|p.M325V(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|urinary_tract(2)	25						TGTGGATGAGATGCACCAGGA	0.587000													2	7					0	0	0.004672	0	0
RNF5	6048	broad.mit.edu	37	6	32148014	32148014	+	Silent	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:32148014C>T	ENST00000375094.3	+	6	612	c.454C>T	c.(454-456)Ctg>Ttg	p.L152L	RNF5_ENST00000427134.2_Intron	NM_006913.3	NP_008844.1	Q99942	RNF5_HUMAN	ring finger protein 5, E3 ubiquitin protein ligase	152					ER-associated misfolded protein catabolic process|protein K48-linked ubiquitination|protein K63-linked ubiquitination	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.L152L(1)		endometrium(1)|lung(7)|urinary_tract(2)	10						AGGTGTGGATCTGGGACAGGG	0.562000													83	175					0	0	0.048971	0	0
ARL13B	200894	broad.mit.edu	37	3	93761858	93761858	+	Splice_Site	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:93761858G>C	ENST00000535334.1	+	6	1012		c.e6-1		ARL13B_ENST00000471138.1_Splice_Site|ARL13B_ENST00000539730.1_Splice_Site|ARL13B_ENST00000303097.7_Splice_Site|ARL13B_ENST00000394222.3_Splice_Site	NM_001174151.1	NP_001167622.1	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 13B								GTP binding	p.?(2)		endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(2)	10						TTTTTTGTTAGAATGAAGGAA	0.313000													2	6					0	0	0.004672	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			9	30					0	0	0.069234	0	0
POLI	11201	broad.mit.edu	37	18	51818253	51818253	+	Nonsense_Mutation	SNP	C	C	T	rs56152401		TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr18:51818253C>T	ENST00000579534.1	+	9	1392	c.1249C>T	c.(1249-1251)Cga>Tga	p.R417*	POLI_ENST00000579434.1_Nonsense_Mutation_p.R314*|POLI_ENST00000217800.5_Nonsense_Mutation_p.R291*|POLI_ENST00000406285.3_Nonsense_Mutation_p.R338*|POLI_ENST00000582366.1_3'UTR	NM_007195.2	NP_009126.2	Q9UNA4	POLI_HUMAN	polymerase (DNA directed) iota	417					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding	p.R392*(1)|p.R417*(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(5)|ovary(3)|urinary_tract(1)	26				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		GAAACTTTTTCGAAATATGGT	0.308000								DNA polymerases (catalytic subunits)					10	41					0	0	0.069234	0	0
SNRPB2	6629	broad.mit.edu	37	20	16719531	16719531	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr20:16719531C>G	ENST00000246071.6	+	5	629	c.413C>G	c.(412-414)tCa>tGa	p.S138*	SNRPB2_ENST00000377943.5_Nonsense_Mutation_p.S138*	NM_003092.4	NP_003083.1	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B	138						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding	p.S138*(1)		large_intestine(2)|lung(2)|urinary_tract(1)	5						CAAGGAAATTCAACACCAAAT	0.338000													8	22					0	0	0.069234	0	0
SRPK3	26576	broad.mit.edu	37	X	153049816	153049816	+	Silent	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chrX:153049816C>T	ENST00000489426.1	+	17	3782	c.1416C>T	c.(1414-1416)atC>atT	p.I472I	SRPK3_ENST00000370104.1_Silent_p.I404I|SRPK3_ENST00000370108.3_Silent_p.I372I|SRPK3_ENST00000393786.3_Silent_p.I371I|SRPK3_ENST00000370101.3_Silent_p.I405I|SRPK3_ENST00000370100.1_Silent_p.I330I			Q9UPE1	SRPK3_HUMAN	SRSF protein kinase 3	405	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity	p.I371I(1)|p.I472I(1)		breast(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(2)|pancreas(2)|urinary_tract(1)	13	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AGATCAAGATCAAGATCGCAG	0.607000													8	6					0	0	0.038147	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	58					0	0	0.004672	0	0
FRG1B	284802	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000439954.2_Silent_p.G100G|FRG1B_ENST00000358464.4_Silent_p.G95G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													4	105					0	0	0.021553	0	0
UBR4	23352	broad.mit.edu	37	1	19441918	19441918	+	Silent	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:19441918C>T	ENST00000375267.2	-	74	11040	c.11037G>A	c.(11035-11037)gaG>gaA	p.E3679E	UBR4_ENST00000375254.3_Silent_p.E3679E|UBR4_ENST00000375218.3_Silent_p.E94E|UBR4_ENST00000375217.2_Silent_p.E3672E|UBR4_ENST00000375226.2_Silent_p.E3655E			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	3679					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding	p.E3679E(1)		breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGTACACATTCTCTCCACAGT	0.517000													17	35					0	0	0.038395	0	0
KIAA0368	23392	broad.mit.edu	37	9	114152334	114152334	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr9:114152334A>C	ENST00000259335.4	-	31	3742	c.3743T>G	c.(3742-3744)cTt>cGt	p.L1248R	KIAA0368_ENST00000374378.3_5'UTR|KIAA0368_ENST00000338205.5_Missense_Mutation_p.L1070R	NM_001080398.1	NP_001073867.1			KIAA0368									p.L1248R(1)		NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						TGGCTGGCTAAGATCACTTGC	0.398000													6	6					0	0	0.029380	0	0
OLFML2B	25903	broad.mit.edu	37	1	161968053	161968053	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:161968053T>A	ENST00000294794.3	-	6	1459	c.1036A>T	c.(1036-1038)Acc>Tcc	p.T346S	OLFML2B_ENST00000367940.2_Missense_Mutation_p.T347S	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	346								p.T346S(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GGCCTCCGGGTGACACTGGTC	0.567000													26	70					0	0	0.083992	0	0
LAMA2	3908	broad.mit.edu	37	6	129691106	129691106	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:129691106G>A	ENST00000421865.2	+	34	4979	c.4930G>A	c.(4930-4932)Gtg>Atg	p.V1644M		NM_000426.3|NM_001079823.1	NP_000417|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1644	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.V1644M(1)		NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAATACACTCGTGACCGAAAT	0.433000													29	31					0	0	0.034045	0	0
CRHR2	1395	broad.mit.edu	37	7	30721547	30721547	+	Silent	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr7:30721547G>C	ENST00000471646.1	-	2	630	c.213C>G	c.(211-213)gtC>gtG	p.V71V	CRHR2_ENST00000348438.4_Silent_p.V98V|CRHR2_ENST00000506074.2_Silent_p.V71V|CRHR2_ENST00000341843.4_Silent_p.V57V	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	71					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding	p.V71V(1)|p.V57V(1)		breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TGTTGTACTTGACGCCGTTGA	0.647000													10	17					0	0	0.105934	0	0
UBTF	7343	broad.mit.edu	37	17	42289089	42289089	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:42289089T>G	ENST00000302904.4	-	10	1424	c.932A>C	c.(931-933)gAg>gCg	p.E311A	UBTF_ENST00000343638.5_Missense_Mutation_p.E274A|UBTF_ENST00000527034.1_Missense_Mutation_p.E274A|CTB-175E5.7_ENST00000586560.1_RNA|UBTF_ENST00000526094.1_Missense_Mutation_p.E274A|UBTF_ENST00000529383.1_Missense_Mutation_p.E311A|UBTF_ENST00000533177.1_Missense_Mutation_p.E274A|UBTF_ENST00000393606.3_Missense_Mutation_p.E274A|UBTF_ENST00000436088.1_Missense_Mutation_p.E311A			P17480	UBF1_HUMAN	upstream binding transcription factor, RNA polymerase I	311					positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding	p.E311A(1)		breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(10)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GGCCATGAGCTCTGCGCAGTA	0.617000													12	51					0	0	0.080935	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209470	140209470	+	Silent	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr5:140209470C>T	ENST00000529310.1	+	1	1908	c.1794C>T	c.(1792-1794)gaC>gaT	p.D598D	PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018909.2|NM_031848.2|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1												p.D598D(2)		NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCAGTTGACGCCGACTCAG	0.667000													3	54					0	0	0.009096	0	0
SMPD1	6609	broad.mit.edu	37	11	6413286	6413286	+	Missense_Mutation	SNP	C	C	T	rs142476839		TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:6413286C>T	ENST00000342245.4	+	2	1159	c.991C>T	c.(991-993)Ccc>Tcc	p.P331S	SMPD1_ENST00000527275.1_Missense_Mutation_p.P330S|SMPD1_ENST00000299397.3_Missense_Mutation_p.P331S|SMPD1_ENST00000356761.2_Missense_Mutation_p.P331S|SMPD1_ENST00000533196.1_3'UTR	NM_000543.4|NM_001007593.2	NP_000534.3|NP_001007594.2	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid lysosomal	329					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity	p.P331S(2)		breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(3)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	TAGCTTCCCTCCCCCCTTCAT	0.612000													13	25					0	0	0.024245	0	0
FAM120A	23196	broad.mit.edu	37	9	96320268	96320268	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr9:96320268C>T	ENST00000277165.6	+	14	2838	c.2644C>T	c.(2644-2646)Cag>Tag	p.Q882*	FAM120A_ENST00000333936.5_Nonsense_Mutation_p.Q910*|FAM120A_ENST00000340893.4_Nonsense_Mutation_p.Q882*	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	882	RNA binding.					cytoplasm|plasma membrane	RNA binding	p.Q882*(1)		endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						CCCACCCTCTCAGGGCAGGGG	0.602000													10	3					0	0	0.069234	0	0
FAM63A	55793	broad.mit.edu	37	1	150974829	150974829	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:150974829C>G	ENST00000361936.5	-	3	1219	c.265G>C	c.(265-267)Gag>Cag	p.E89Q	FAM63A_ENST00000361738.6_Missense_Mutation_p.E137Q|FAM63A_ENST00000312210.5_Intron|FAM63A_ENST00000470877.1_Intron|FAM63A_ENST00000493834.2_5'UTR	NM_018379.4	NP_060849	Q8N5J2	FA63A_HUMAN	family with sequence similarity 63, member A	89							protein binding	p.E89Q(1)		breast(1)|endometrium(3)|large_intestine(4)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTTATTGTCTCTACTTCAGGC	0.582000													23	39					0	0	0.069288	0	0
USP20	10868	broad.mit.edu	37	9	132614875	132614875	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr9:132614875T>G	ENST00000315480.4	+	3	199	c.41T>G	c.(40-42)aTa>aGa	p.I14R	USP20_ENST00000372429.3_Missense_Mutation_p.I14R|USP20_ENST00000358355.1_Missense_Mutation_p.I14R			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	14					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding	p.I14R(3)		breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				CTTGACTCCATAGGAGAGGTG	0.577000													2	4					0	0	0.004672	0	0
CYP26A1	1592	broad.mit.edu	37	10	94836820	94836820	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:94836820G>A	ENST00000371531.1	+	7	1424	c.1046G>A	c.(1045-1047)cGa>cAa	p.R349Q	CYP26A1_ENST00000394139.1_Missense_Mutation_p.R349Q|CYP26A1_ENST00000224356.4_Missense_Mutation_p.R418Q	NM_057157.2	NP_476498.1	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A, polypeptide 1	418					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding	p.R349Q(1)		breast(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Colorectal(252;0.122)				AATCCTGACCGATTCATGCTG	0.448000													17	51					0	0	0.033300	0	0
SNX33	257364	broad.mit.edu	37	15	75941596	75941596	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr15:75941596T>G	ENST00000308527.5	+	1	1350	c.153T>G	c.(151-153)ttT>ttG	p.F51L		NM_153271.1	NP_695003.1	Q8WV41	SNX33_HUMAN	sorting nexin 33	51	SH3.				cell communication		phosphatidylinositol binding|protein binding	p.F51L(1)		breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	19						CAGGGCTCTTTCCTGCCTCTT	0.587000													23	61					0	0	0.076483	0	0
ELP5	23587	broad.mit.edu	37	17	7162193	7162193	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:7162193G>C	ENST00000396628.2	+	7	1001	c.784G>C	c.(784-786)Gag>Cag	p.E262Q	RP1-4G17.5_ENST00000577138.1_Intron|ELP5_ENST00000356683.2_3'UTR|ELP5_ENST00000354429.2_Missense_Mutation_p.E262Q|ELP5_ENST00000574993.1_3'UTR|ELP5_ENST00000396627.2_Missense_Mutation_p.E262Q	NM_203414.1	NP_981959.1			elongator acetyltransferase complex subunit 5									p.E262Q(1)									GTCCAAGAAAGAGAGAGAAGC	0.512000													17	21					0	0	0.028581	0	0
MAB21L3	126868	broad.mit.edu	37	1	116670903	116670903	+	Silent	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:116670903G>A	ENST00000369500.3	+	6	1063	c.798G>A	c.(796-798)ctG>ctA	p.L266L		NM_152367.2	NP_689580.2	Q8N8X9	MB213_HUMAN	mab-21-like 3 (C. elegans)	266								p.L266L(1)		breast(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|urinary_tract(1)	19						TGAGGCACCTGAAGGAGGACA	0.587000													4	23					0	0	0.009096	0	0
TFRC	7037	broad.mit.edu	37	3	195794923	195794923	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:195794923C>T	ENST00000360110.4	-	8	1049	c.880G>A	c.(880-882)Gaa>Aaa	p.E294K	TFRC_ENST00000420415.1_Missense_Mutation_p.E213K|TFRC_ENST00000540528.1_3'UTR|TFRC_ENST00000535031.1_Missense_Mutation_p.E12K|TFRC_ENST00000392396.3_Missense_Mutation_p.E294K	NM_001128148.1	NP_001121620.1	P02786	TFR1_HUMAN	transferrin receptor	294	PA.				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity	p.E294K(1)		NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		AATGAAAGTTCTGCGTTAACA	0.353000			T	BCL6	NHL								7	33					0	0	0.029380	0	0
COL19A1	1310	broad.mit.edu	37	6	70875870	70875870	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:70875870G>C	ENST00000322773.4	+	37	2540	c.2438G>C	c.(2437-2439)gGa>gCa	p.G813A	COL19A1_ENST00000393344.1_Missense_Mutation_p.G435A	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	813	Triple-helical region 4 (COL4).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging	p.G813A(1)		breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						GGACCACCTGGACCACCTGTG	0.428000													3	136					0	0	0.004672	0	0
HPR	3250	broad.mit.edu	37	16	72110371	72110371	+	Silent	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:72110371C>G	ENST00000540303.2	+	5	470	c.438C>G	c.(436-438)ctC>ctG	p.L146L	HPR_ENST00000228226.8_Silent_p.L183L|HPR_ENST00000561690.1_Intron|HPR_ENST00000356967.5_Silent_p.L146L	NM_020995.3	NP_066275.3	P00739	HPTR_HUMAN	haptoglobin-related protein	146	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity	p.L146L(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|stomach(1)|urinary_tract(2)	20		Ovarian(137;0.125)				CTAAAAATCTCTTCCTGAACC	0.478000													13	24					0	0	0.093190	0	0
BRWD1	54014	broad.mit.edu	37	21	40604198	40604198	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr21:40604198G>A	ENST00000342449.3	-	25	2983	c.2905C>T	c.(2905-2907)Cga>Tga	p.R969*	BRWD1_ENST00000333229.2_Nonsense_Mutation_p.R969*|BRWD1_ENST00000380800.3_Nonsense_Mutation_p.R969*	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	969					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus		p.R969*(2)		cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TGACCCTGTCGAAAATATATT	0.308000													6	33					0	0	0.029380	0	0
NBPF1	55672	broad.mit.edu	37	1	16918403	16918403	+	Silent	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:16918403G>C	ENST00000430580.2	-	7	1001	c.114C>G	c.(112-114)ctC>ctG	p.L38L		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	38						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ATTTCTCTTTGAGGTTTCTGA	0.468000													60	952					0	0	0.048971	0	0
IFT140	9742	broad.mit.edu	37	16	1616196	1616196	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:1616196C>G	ENST00000426508.2	-	16	2230	c.1867G>C	c.(1867-1869)Gag>Cag	p.E623Q	IFT140_ENST00000439987.2_5'UTR	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	623								p.E623Q(1)		breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				GACAGCGTCTCTCTCCGATCA	0.428000													57	135					0	0	0.048971	0	0
PTPN14	5784	broad.mit.edu	37	1	214557171	214557171	+	Missense_Mutation	SNP	G	G	A	rs139115216	by1000genomes	TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:214557171G>A	ENST00000366956.5	-	13	2221	c.2027C>T	c.(2026-2028)cCg>cTg	p.P676L	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	676					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding	p.P676L(1)		NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CTCCTCGGGCGGTCCCTGCTC	0.632000													16	27					0	0	0.028581	0	0
ELP5	23587	broad.mit.edu	37	17	7162148	7162148	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:7162148G>A	ENST00000396628.2	+	7	956	c.739G>A	c.(739-741)Gat>Aat	p.D247N	RP1-4G17.5_ENST00000577138.1_Intron|ELP5_ENST00000356683.2_3'UTR|ELP5_ENST00000354429.2_Missense_Mutation_p.D247N|ELP5_ENST00000574993.1_3'UTR|ELP5_ENST00000396627.2_Missense_Mutation_p.D247N	NM_203414.1	NP_981959.1			elongator acetyltransferase complex subunit 5									p.D247N(1)									CCTACAGGTGGATCCCACAAC	0.502000													18	20					0	0	0.033300	0	0
ARL13B	200894	broad.mit.edu	37	3	93761880	93761880	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:93761880G>C	ENST00000535334.1	+	6	1034	c.511G>C	c.(511-513)Gag>Cag	p.E171Q	ARL13B_ENST00000471138.1_Missense_Mutation_p.E274Q|ARL13B_ENST00000539730.1_5'UTR|ARL13B_ENST00000303097.7_Missense_Mutation_p.E167Q|ARL13B_ENST00000394222.3_Missense_Mutation_p.E274Q	NM_001174151.1	NP_001167622.1	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 13B	274							GTP binding	p.E274Q(1)|p.E167Q(1)		endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(2)	10						ACTTGAAAGAGAGAAAAAAAA	0.328000													4	10					0	0	0.009096	0	0
CPE	1363	broad.mit.edu	37	4	166414359	166414359	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:166414359C>T	ENST00000402744.4	+	7	1430	c.1150C>T	c.(1150-1152)Caa>Taa	p.Q384*		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	384					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding	p.Q384*(1)		endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCGAGACCTTCAAGGTAACCC	0.408000											OREG0016391	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	36					0	0	0.028581	0	0
IL2RG	3561	broad.mit.edu	37	X	70331308	70331308	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chrX:70331308G>C	ENST00000374202.2	-	1	173	c.82C>G	c.(82-84)Ctg>Gtg	p.L28V		NM_000206.2	NP_000197.1	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma	28					immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding	p.L28V(2)		breast(1)|endometrium(3)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	15	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	TTGGGCGTCAGAATTGTCGTG	0.562000									Severe Combined Immunodeficiency, X-linked				12	9					0	0	0.093190	0	0
ARMC3	219681	broad.mit.edu	37	10	23321935	23321935	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:23321935C>T	ENST00000298032.5	+	18	2476	c.2392C>T	c.(2392-2394)Cga>Tga	p.R798*	ARMC3_ENST00000409983.3_Nonsense_Mutation_p.R791*|ARMC3_ENST00000376528.4_Nonsense_Mutation_p.R535*	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	798							binding	p.R798*(1)		breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CTTCTACCATCGAGCTTTGCT	0.363000													20	43					0	0	0.076483	0	0
BMI1	648	broad.mit.edu	37	10	22616891	22616891	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:22616891C>G	ENST00000376663.3	+	6	834	c.329C>G	c.(328-330)tCt>tGt	p.S110C	COMMD3-BMI1_ENST00000602390.1_Missense_Mutation_p.S253C	NM_005180.8	NP_005171.4			BMI1 polycomb ring finger oncogene									p.S110C(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(2)|urinary_tract(1)	12						GCCAATGGCTCTAATGAAGAT	0.308000													15	63					0	0	0.028581	0	0
HMCN1	83872	broad.mit.edu	37	1	186113383	186113383	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:186113383G>A	ENST00000271588.4	+	90	14232	c.14003G>A	c.(14002-14004)aGa>aAa	p.R4668K	HMCN1_ENST00000367492.2_Missense_Mutation_p.R4668K	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4668	TSP type-1 3.				response to stimulus|visual perception	basement membrane	calcium ion binding	p.R4668K(1)		NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ACAAGAGCAAGACTTTGTAAT	0.478000													37	106					0	0	0.080422	0	0
ZNF777	27153	broad.mit.edu	37	7	149129112	149129112	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr7:149129112C>T	ENST00000247930.4	-	6	2574	c.2251G>A	c.(2251-2253)Gcc>Acc	p.A751T		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.A751T(1)		large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TCGGGGCAGGCGTGCGGCCGC	0.682000													28	44					0	0	0.030593	0	0
SNHG14	104472715	broad.mit.edu	37	15	25470410	25470410	+	RNA	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr15:25470410C>T	ENST00000453082.2	+	0	1061				SNORD115-30_ENST00000364117.1_RNA	NR_003343.1																						AAATCATGCTCAATAGGATTA	0.498000													67	152					0	0	0.048971	0	0
PSEN2	5664	broad.mit.edu	37	1	227071519	227071519	+	Silent	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:227071519G>A	ENST00000366782.1	+	5	854	c.354G>A	c.(352-354)gcG>gcA	p.A118A	PSEN2_ENST00000340188.4_Silent_p.A85A|PSEN2_ENST00000366783.3_Silent_p.A85A|PSEN2_ENST00000422240.2_Silent_p.A85A|PSEN2_ENST00000391872.2_Silent_p.A118A			P49810	PSN2_HUMAN	presenilin 2 (Alzheimer disease 4)	85					amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding	p.A85A(1)		cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|urinary_tract(1)	20		Prostate(94;0.0771)				AATACGGAGCGAAGCACGTGA	0.582000													19	50					0	0	0.049695	0	0
TET2	54790	broad.mit.edu	37	4	106156625	106156625	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:106156625C>G	ENST00000540549.1	+	3	2386	c.1526C>G	c.(1525-1527)tCa>tGa	p.S509*	TET2_ENST00000413648.2_Nonsense_Mutation_p.S509*|TET2_ENST00000380013.4_Nonsense_Mutation_p.S509*|TET2_ENST00000305737.2_Nonsense_Mutation_p.S509*|TET2_ENST00000394764.1_Nonsense_Mutation_p.S509*|TET2_ENST00000545826.1_Nonsense_Mutation_p.S509*|TET2_ENST00000513237.1_Nonsense_Mutation_p.S530*			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	509					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.S509*(6)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		AGACCAATGTCAGAACACCTC	0.433000			"""Mis N, F"""		MDS								11	37					0	0	0.069234	0	0
IL17B	27190	broad.mit.edu	37	5	148754143	148754143	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr5:148754143C>T	ENST00000261796.3	-	3	382	c.332G>A	c.(331-333)cGt>cAt	p.R111H	RP11-394O4.3_ENST00000521756.1_RNA|IL17B_ENST00000505432.1_5'UTR	NM_014443.2	NP_055258.1	Q9UHF5	IL17B_HUMAN	interleukin 17B	111					cell-cell signaling|immune response|inflammatory response	extracellular space	cytokine activity|signal transducer activity	p.R111H(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)|urinary_tract(1)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGGGGATACGGCTGGGGTC	0.627000													6	21					0	0	0.021553	0	0
VPS13D	55187	broad.mit.edu	37	1	12422812	12422812	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:12422812A>T	ENST00000358136.3	+	51	10308	c.10178A>T	c.(10177-10179)gAt>gTt	p.D3393V	VPS13D_ENST00000356315.4_Missense_Mutation_p.D3368V	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3392					protein localization			p.D3393V(1)		NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CGATACATTGATACCTGCATG	0.428000													68	142					0	0	0.048971	0	0
DDIT4	54541	broad.mit.edu	37	10	74034918	74034918	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:74034918C>T	ENST00000307365.3	+	3	872	c.671C>T	c.(670-672)tCg>tTg	p.S224L	RP11-442H21.2_ENST00000491934.2_RNA	NM_019058.2	NP_061931.1	Q9NX09	DDIT4_HUMAN	DNA-damage-inducible transcript 4	224					apoptosis			p.S224L(1)		cervix(1)|endometrium(2)|lung(5)|pancreas(1)|prostate(2)|urinary_tract(1)	12						CTGTACAGCTCGGAACAGCTG	0.567000											OREG0020262	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	10					0	0	0.014758	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160253617	160253617	+	Silent	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:160253617C>T	ENST00000264431.4	+	11	1839	c.1420C>T	c.(1420-1422)Cta>Tta	p.L474L		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	474					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity	p.L462L(1)		breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TAAAGAACTTCTAACAAGATT	0.358000													18	43					0	0	0.049695	0	0
SP3	6670	broad.mit.edu	37	2	174783487	174783487	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:174783487C>T	ENST00000310015.6	-	5	2196	c.1666G>A	c.(1666-1668)Gat>Aat	p.D556N	SP3_ENST00000455789.2_Missense_Mutation_p.D503N|SP3_ENST00000418194.2_Missense_Mutation_p.D488N	NM_001172712.1|NM_003111.4	NP_001166183.1|NP_003102.1	Q02447	SP3_HUMAN	Sp3 transcription factor	556	Repressor domain.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding	p.D556N(1)	EWSR1/SP3(3)	NS(2)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.185)			TCTTCAGGATCAGGTTCTTCT	0.403000													17	39					0	0	0.033300	0	0
CYP2E1	1571	broad.mit.edu	37	10	135350733	135350733	+	Silent	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:135350733C>T	ENST00000463117.2	+	9	1406	c.1134C>T	c.(1132-1134)ttC>ttT	p.F378F	SPRN_ENST00000541506.1_Intron|CYP2E1_ENST00000252945.3_Silent_p.F378F			P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E, polypeptide 1	378					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding	p.F378F(1)		NS(1)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(7)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	ACACCATTTTCAGAGGATACC	0.542000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				19	27					0	0	0.055883	0	0
CACNA1S	779	broad.mit.edu	37	1	201060841	201060841	+	Silent	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:201060841G>C	ENST00000362061.3	-	5	847	c.621C>G	c.(619-621)gtC>gtG	p.V207V	CACNA1S_ENST00000367338.3_Silent_p.V207V	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	207					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity	p.V207V(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CATAGATGATGACCATAAAGA	0.562000													14	45					0	0	0.105934	0	0
KRTAP10-6	386674	broad.mit.edu	37	21	46011400	46011400	+	Silent	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr21:46011400G>A	ENST00000400368.1	-	1	986	c.966C>T	c.(964-966)tcC>tcT	p.S322S	TSPEAR_ENST00000323084.4_Intron	NM_198688.2	NP_941961.2	P60371	KR106_HUMAN	keratin associated protein 10-6	322	29 X 5 AA repeats of C-C-X(3).					keratin filament		p.S322S(5)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(6)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23						AGGCACCACAGGAGGGGACGG	0.692000													3	49					0	0	0.014758	0	0
WBP5	51186	broad.mit.edu	37	X	102612724	102612724	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chrX:102612724G>A	ENST00000372661.3	+	3	423	c.112G>A	c.(112-114)Gag>Aag	p.E38K	WBP5_ENST00000372656.3_Missense_Mutation_p.E38K	NM_001006612.1|NM_016303.2	NP_001006613.1|NP_057387.1	Q9UHQ7	WPB5_HUMAN	WW domain binding protein 5	38	Glu-rich.							p.E38K(1)		breast(2)|endometrium(2)|large_intestine(2)|ovary(1)|urinary_tract(1)	8						GCTAGAGGAGGAGGCCAAAGC	0.408000													21	13					0	0	0.055883	0	0
MSANTD4	84437	broad.mit.edu	37	11	105880796	105880796	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:105880796T>C	ENST00000301919.4	-	3	1919	c.504A>G	c.(502-504)atA>atG	p.I168M		NM_032424.1	NP_115800.1	Q8NCY6	K1826_HUMAN	Myb/SANT-like DNA-binding domain containing 4 with coiled-coils	168						nucleus		p.I168M(1)									TGGAATCTGGTATGACGGATG	0.393000													35	57					0	0	0.064281	0	0
VPS8	23355	broad.mit.edu	37	3	184557485	184557485	+	Splice_Site	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:184557485G>A	ENST00000287546.4	+	7	651		c.e7-1		VPS8_ENST00000446204.2_Splice_Site|VPS8_ENST00000424463.2_3'UTR|VPS8_ENST00000437079.3_Splice_Site|VPS8_ENST00000436792.2_Splice_Site	NM_015303.3	NP_056118.2	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)								zinc ion binding	p.?(1)		NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TTTGTTTTCAGGCAGTATCCA	0.358000													7	12					0	0	0.038147	0	0
TBXAS1	6916	broad.mit.edu	37	7	139636073	139636073	+	Silent	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr7:139636073G>A	ENST00000263552.6	+	9	958	c.420G>A	c.(418-420)ctG>ctA	p.L140L	TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000414508.2_Silent_p.L140L|TBXAS1_ENST00000416849.2_Silent_p.L140L|TBXAS1_ENST00000448866.1_Silent_p.L139L|TBXAS1_ENST00000458722.1_Silent_p.L139L|TBXAS1_ENST00000411653.1_Silent_p.L139L|TBXAS1_ENST00000436047.2_Silent_p.L140L|TBXAS1_ENST00000425687.1_Silent_p.L72L|TBXAS1_ENST00000336425.5_Silent_p.L139L	NM_001130966.2	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	139					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity	p.L140L(2)		breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					GAGGTGCCCTGATGTCTGCTT	0.473000													65	134					0	0	0.048971	0	0
PUS7L	83448	broad.mit.edu	37	12	44124323	44124323	+	Silent	SNP	T	T	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr12:44124323T>C	ENST00000416848.2	-	9	2450	c.1962A>G	c.(1960-1962)caA>caG	p.Q654Q	PUS7L_ENST00000431332.3_Silent_p.Q341Q|PUS7L_ENST00000344862.5_Silent_p.Q654Q|PUS7L_ENST00000551923.1_Silent_p.Q654Q	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	654					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding	p.Q654Q(1)		NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		CTTCCATTAGTTGGTATGAGA	0.368000													34	92					0	0	0.074837	0	0
NLRP8	126205	broad.mit.edu	37	19	56466176	56466176	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:56466176C>T	ENST00000291971.3	+	3	823	c.752C>T	c.(751-753)aCg>aTg	p.T251M	NLRP8_ENST00000590542.1_Missense_Mutation_p.T251M	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	251	NACHT.					cytoplasm	ATP binding	p.T251M(1)		breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GTGAACCAGACGACAGACCAG	0.512000													38	75					0	0	0.080422	0	0
TNFSF4	7292	broad.mit.edu	37	1	173176222	173176222	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:173176222G>A	ENST00000281834.3	-	1	230	c.94C>T	c.(94-96)Cag>Tag	p.Q32*		NM_003326.3	NP_003317.1	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily, member 4	32					acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity	p.Q32*(1)		breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	12						CCCAGTCCCTGAATTACAGAG	0.537000													15	35					0	0	0.020292	0	0
KANSL1	284058	broad.mit.edu	37	17	44109507	44109507	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:44109507G>C	ENST00000262419.6	-	14	3466	c.2996C>G	c.(2995-2997)tCa>tGa	p.S999*	KANSL1_ENST00000574590.1_Nonsense_Mutation_p.S999*|KANSL1_ENST00000572904.1_Nonsense_Mutation_p.S999*|KANSL1_ENST00000393476.3_Nonsense_Mutation_p.S293*|KANSL1_ENST00000575318.1_Nonsense_Mutation_p.S935*|KANSL1_ENST00000432791.1_Nonsense_Mutation_p.S999*	NM_001193466.1	NP_001180395	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	999						MLL1 complex	protein binding	p.S999*(1)									GAGGGGTGCTGAGTGCAGTTC	0.602000													11	55					0	0	0.069234	0	0
GPR39	2863	broad.mit.edu	37	2	133174772	133174772	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:133174772C>T	ENST00000329321.3	+	1	626	c.157C>T	c.(157-159)Cgg>Tgg	p.R53W		NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	53						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding	p.R53W(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CGCCACCATTCGGGTCACCCA	0.537000													19	32					0	0	0.049695	0	0
LENG8	114823	broad.mit.edu	37	19	54967251	54967251	+	Silent	SNP	T	T	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:54967251T>G	ENST00000326764.5	+	9	1610	c.1131T>G	c.(1129-1131)ggT>ggG	p.G377G	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	340	Ser-rich.						protein binding	p.G377G(2)		breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GGGGCGGGGGTGCCCCGTCCC	0.687000													6	24					0	0	0.058154	0	0
SYNE1	23345	broad.mit.edu	37	6	152668238	152668238	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:152668238C>T	ENST00000367255.5	-	73	12635	c.12034G>A	c.(12034-12036)Ggc>Agc	p.G4012S	SYNE1_ENST00000265368.4_Missense_Mutation_p.G4012S|SYNE1_ENST00000341594.5_Intron|SYNE1_ENST00000423061.1_Missense_Mutation_p.G3941S|SYNE1_ENST00000448038.1_Missense_Mutation_p.G3941S	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4012					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.G4012S(2)|p.G3941S(1)		NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCCTTTGTGCCCTGCAGATGA	0.493000										HNSCC(10;0.0054)			12	39					0	0	0.020292	0	0
OR10A6	390093	broad.mit.edu	37	11	7949563	7949563	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:7949563A>G	ENST00000309838.2	-	1	646	c.647T>C	c.(646-648)tTg>tCg	p.L216S		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L216S(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AATGTAAGACAAGAGTATCAA	0.438000													18	43					0	0	0.043863	0	0
SNX22	79856	broad.mit.edu	37	15	64446590	64446590	+	Silent	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr15:64446590G>C	ENST00000325881.4	+	7	524	c.465G>C	c.(463-465)tcG>tcC	p.S155S		NM_024798.2	NP_079074.2	Q96L94	SNX22_HUMAN	sorting nexin 22	155					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding	p.S155S(1)		large_intestine(3)|lung(1)|urinary_tract(2)	6						CCACAGAGTCGCTGCCCAACG	0.602000											OREG0023180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	111					0	0	0.049695	0	0
CCDC36	339834	broad.mit.edu	37	3	49249266	49249266	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:49249266C>T	ENST00000438782.1	+	2	289	c.53C>T	c.(52-54)tCt>tTt	p.S18F	CCDC36_ENST00000452691.2_Missense_Mutation_p.S18F|CCDC36_ENST00000366429.2_Missense_Mutation_p.S18F|CCDC36_ENST00000493870.1_Intron|CCDC36_ENST00000296449.5_Missense_Mutation_p.S18F			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	18								p.S8F(1)		endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		CCTTCAGGCTCTGGGTAAGTT	0.388000													21	61					0	0	0.069288	0	0
C16orf59	80178	broad.mit.edu	37	16	2510687	2510687	+	Silent	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:2510687C>T	ENST00000569496.1	+	3	248	c.189C>T	c.(187-189)ccC>ccT	p.P63P	C16orf59_ENST00000361837.4_Silent_p.P63P|C16orf59_ENST00000483320.1_5'UTR|C16orf59_ENST00000563531.1_Silent_p.P63P			Q7L2K0	CP059_HUMAN	chromosome 16 open reading frame 59	63								p.P63P(1)		lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				GAGAGGACCCCCTTCCAGGTA	0.637000													12	16					0	0	0.093190	0	0
KMT2A	4297	broad.mit.edu	37	11	118374590	118374590	+	Missense_Mutation	SNP	G	G	C	rs142807735	byFrequency	TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:118374590G>C	ENST00000534358.1	+	27	8006	c.7983G>C	c.(7981-7983)aaG>aaC	p.K2661N	KMT2A_ENST00000354520.4_Missense_Mutation_p.K2620N|KMT2A_ENST00000389506.5_Missense_Mutation_p.K2658N	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A									p.K2661N(1)|p.K2658N(1)									AGCGAGGCAAGAGATCAGCTG	0.443000													9	31					0	0	0.069234	0	0
CCDC36	339834	broad.mit.edu	37	3	49249260	49249260	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:49249260C>A	ENST00000438782.1	+	2	283	c.47C>A	c.(46-48)tCa>tAa	p.S16*	CCDC36_ENST00000452691.2_Nonsense_Mutation_p.S16*|CCDC36_ENST00000366429.2_Nonsense_Mutation_p.S16*|CCDC36_ENST00000493870.1_Intron|CCDC36_ENST00000296449.5_Nonsense_Mutation_p.S16*			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	16								p.S6*(1)		endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		AGTATTCCTTCAGGCTCTGGG	0.383000													22	63					3.7963e-18	3.98085e-18	0.083992	1	0
ARHGEF26	26084	broad.mit.edu	37	3	153840100	153840100	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:153840100C>G	ENST00000356448.4	+	2	603	c.319C>G	c.(319-321)Cga>Gga	p.R107G	ARHGEF26_ENST00000465093.1_Missense_Mutation_p.R107G|ARHGEF26_ENST00000465817.1_Missense_Mutation_p.R107G	NM_001251962.1	NP_001238891.1	Q96DR7	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 26	107	Pro-rich.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity	p.R107G(3)		endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	23						TGCCTCTCCTCGACTTCGACG	0.687000													5	17					0	0	0.021553	0	0
COL1A1	1277	broad.mit.edu	37	17	48275121	48275121	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:48275121G>C	ENST00000225964.5	-	9	786	c.668C>G	c.(667-669)cCa>cGa	p.P223R		NM_000088.3	NP_000079	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	223	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding	p.P223R(1)	COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	AGGGGGACCTGGGGGACCTCG	0.507000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						36	126					0	0	0.086207	0	0
COL5A2	1290	broad.mit.edu	37	2	189953486	189953486	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:189953486G>C	ENST00000374866.3	-	8	854	c.580C>G	c.(580-582)Caa>Gaa	p.Q194E		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	194					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent	p.Q194E(1)		NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCAGCCATTTGAGCTGAAAAC	0.378000													25	75					0	0	0.108266	0	0
NCOR1	9611	broad.mit.edu	37	17	16022773	16022773	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:16022773G>A	ENST00000268712.3	-	17	2136	c.1879C>T	c.(1879-1881)Cga>Tga	p.R627*	NCOR1_ENST00000395851.1_Nonsense_Mutation_p.R627*|NCOR1_ENST00000583226.1_5'UTR|NCOR1_ENST00000395848.1_Nonsense_Mutation_p.R518*	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	627	SANT 2.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding	p.R627*(1)		NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TCTGTCCATCGAGAGGTCTCC	0.333000													31	38					0	0	0.086207	0	0
CSMD1	64478	broad.mit.edu	37	8	3326258	3326258	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr8:3326258G>A	ENST00000520002.1	-	13	2095	c.1540C>T	c.(1540-1542)Cct>Tct	p.P514S	CSMD1_ENST00000537824.1_Missense_Mutation_p.P513S|CSMD1_ENST00000539096.1_Missense_Mutation_p.P513S|CSMD1_ENST00000602723.1_Missense_Mutation_p.P514S|CSMD1_ENST00000400186.3_Missense_Mutation_p.P514S|CSMD1_ENST00000542608.1_Missense_Mutation_p.P513S|CSMD1_ENST00000602557.1_Missense_Mutation_p.P514S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	514	CUB 3.					integral to membrane		p.P242S(1)|p.P513S(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTAAACCCAGGTGAGCCAATG	0.478000													7	9					0	0	0.029380	0	0
NIPBL	25836	broad.mit.edu	37	5	36985880	36985880	+	Silent	SNP	A	A	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr5:36985880A>G	ENST00000282516.8	+	10	3097	c.2598A>G	c.(2596-2598)ctA>ctG	p.L866L	NIPBL_ENST00000448238.2_Silent_p.L866L|NIPBL_ENST00000504430.1_3'UTR	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	866					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding	p.L866L(2)		autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CTGATAAACTAGAACGAAAAC	0.413000													14	20					0	0	0.020292	0	0
CPPED1	55313	broad.mit.edu	37	16	12758794	12758794	+	Silent	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:12758794C>G	ENST00000381774.4	-	4	1134	c.894G>C	c.(892-894)ctG>ctC	p.L298L	CPPED1_ENST00000433677.2_Silent_p.L156L|CPPED1_ENST00000261660.4_3'UTR	NM_018340.2	NP_060810.2	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain containing 1	298							hydrolase activity|metal ion binding	p.L298L(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|urinary_tract(1)	18						CTTTCTCACTCAGCTCATCTA	0.478000													26	43					0	0	0.034045	0	0
ANKAR	150709	broad.mit.edu	37	2	190593544	190593544	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:190593544A>G	ENST00000520309.1	+	15	3278	c.3190A>G	c.(3190-3192)Att>Gtt	p.I1064V	ANKAR_ENST00000313581.4_Missense_Mutation_p.I1064V|ANKAR_ENST00000431575.2_Missense_Mutation_p.I993V|ANKAR_ENST00000438402.2_Missense_Mutation_p.I1064V|ANKAR_ENST00000281412.6_Intron	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1064						integral to membrane	binding	p.I993V(1)|p.I1064V(1)		breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			ATCCATTTGTATTGGTTTGTA	0.393000													31	48					0	0	0.037714	0	0
MRPS17	51373	broad.mit.edu	37	7	56022649	56022649	+	Silent	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr7:56022649G>A	ENST00000285298.4	+	3	300	c.171G>A	c.(169-171)caG>caA	p.Q57Q	MRPS17_ENST00000426595.1_Silent_p.Q152Q	NM_015969.2	NP_057053.1	Q9Y2R5	RT17_HUMAN	mitochondrial ribosomal protein S17	57					translation	mitochondrial small ribosomal subunit	rRNA binding|structural constituent of ribosome	p.Q57Q(1)		kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CCCTTCAGCAGTGCACAGTTG	0.443000													88	212					0	0	0.048971	0	0
LRP1B	53353	broad.mit.edu	37	2	141272335	141272335	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:141272335G>T	ENST00000389484.3	-	51	9127	c.8156C>A	c.(8155-8157)tCt>tAt	p.S2719Y		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2719	LDL-receptor class A 16.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.S2719Y(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCAAGAGCAAGAAGAATCTAG	0.363000										TSP Lung(27;0.18)			13	26					7.03913e-09	7.28019e-09	0.093190	1	0
RNF112	7732	broad.mit.edu	37	17	19319463	19319463	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:19319463G>A	ENST00000461366.1	+	14	2086	c.1871G>A	c.(1870-1872)cGa>cAa	p.R624Q		NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	624							GTP binding|GTPase activity|zinc ion binding	p.R625Q(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						GAAGGGGACCGAGAGCCCCTT	0.627000													10	25					0	0	0.069234	0	0
KNOP1	400506	broad.mit.edu	37	16	19726111	19726111	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:19726111C>G	ENST00000219837.7	-	2	325	c.247G>C	c.(247-249)Gaa>Caa	p.E83Q	AC002550.5_ENST00000565916.1_RNA	NM_001012991.2	NP_001013009.2			lysine-rich nucleolar protein 1									p.E83Q(1)									GTCTCAGGTTCTACATGCTCC	0.522000													16	37					0	0	0.038395	0	0
CCDC87	55231	broad.mit.edu	37	11	66359214	66359214	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:66359214G>A	ENST00000333861.3	-	1	1340	c.1273C>T	c.(1273-1275)Cac>Tac	p.H425Y		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	425								p.H425Y(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GGCTGTGGGTGAAGTGGAAAG	0.552000													18	39					0	0	0.038395	0	0
GNAZ	2781	broad.mit.edu	37	22	23465561	23465561	+	Silent	SNP	C	C	T	rs139659965		TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr22:23465561C>T	ENST00000248996.4	+	3	1677	c.1011C>T	c.(1009-1011)ttC>ttT	p.F337F	RTDR1_ENST00000216036.4_Intron	NM_002073.2	NP_002064.1	P19086	GNAZ_HUMAN	guanine nucleotide binding protein (G protein), alpha z polypeptide	337						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity	p.F337F(1)		endometrium(3)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(5)|urinary_tract(1)	19	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		AGTTTGTCTTCGACGCGGTGA	0.562000													13	16					0	0	0.024245	0	0
ASAH2	56624	broad.mit.edu	37	10	51974561	51974561	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:51974561C>T	ENST00000395526.4	-	8	1081	c.1082G>A	c.(1081-1083)cGt>cAt	p.R361H	ASAH2_ENST00000447815.1_Missense_Mutation_p.R361H|ASAH2_ENST00000443575.1_Missense_Mutation_p.R203H|ASAH2_ENST00000329428.6_Missense_Mutation_p.R342H	NM_019893.2	NP_063946.2	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2						apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity	p.R342H(1)|p.R361H(1)		large_intestine(1)|lung(9)|urinary_tract(1)	11						GTTGATGCAACGTGGTCCAAG	0.448000													19	28					0	0	0.069288	0	0
SZRD1	26099	broad.mit.edu	37	1	16721628	16721628	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:16721628G>A	ENST00000401088.4	+	4	627	c.452G>A	c.(451-453)cGc>cAc	p.R151H	SZRD1_ENST00000472461.1_3'UTR|SZRD1_ENST00000375590.3_Silent_p.A114A|SZRD1_ENST00000492354.1_Missense_Mutation_p.R131H|SZRD1_ENST00000471507.1_Missense_Mutation_p.R150H|SZRD1_ENST00000401089.3_Missense_Mutation_p.R132H	NM_001114600.1|NM_001271869.1	NP_001108072.1|NP_001258798.1			SUZ RNA binding domain containing 1									p.R132H(1)|p.R151H(1)									TTCAAACAGCGCAGATAAATG	0.582000													5	16					0	0	0.021553	0	0
CHD9	80205	broad.mit.edu	37	16	53272307	53272307	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:53272307A>G	ENST00000566029.1	+	12	2895	c.2686A>G	c.(2686-2688)Att>Gtt	p.I896V	CHD9_ENST00000398510.3_Missense_Mutation_p.I896V|CHD9_ENST00000564845.1_Missense_Mutation_p.I896V|CHD9_ENST00000447540.1_Missense_Mutation_p.I896V			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	896	Helicase ATP-binding.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding	p.I896V(2)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				TATTCAATCAATTACATTCCT	0.358000													18	32					0	0	0.049695	0	0
CEP250	11190	broad.mit.edu	37	20	34051427	34051427	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr20:34051427G>C	ENST00000397527.1	+	5	934	c.214G>C	c.(214-216)Gag>Cag	p.E72Q	CEP250_ENST00000397524.1_Missense_Mutation_p.E72Q|CEP250_ENST00000342580.4_Missense_Mutation_p.E72Q	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	72					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding	p.E72Q(1)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CTGGTGCCAAGAGCTGGAGAA	0.547000											OREG0025891	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	25					0	0	0.021553	0	0
ARHGEF3	50650	broad.mit.edu	37	3	56787589	56787589	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:56787589G>C	ENST00000413728.2	-	4	942	c.399C>G	c.(397-399)atC>atG	p.I133M	ARHGEF3_ENST00000496106.1_Missense_Mutation_p.I133M|ARHGEF3_ENST00000495373.1_Missense_Mutation_p.I127M|ARHGEF3_ENST00000498517.1_5'UTR|ARHGEF3_ENST00000296315.3_Missense_Mutation_p.I127M|ARHGEF3_ENST00000497267.1_Missense_Mutation_p.I98M|ARHGEF3_ENST00000338458.4_Missense_Mutation_p.I159M	NM_001128616.1	NP_001122088.1	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor (GEF) 3	127	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity	p.I127M(2)|p.I159M(1)		cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	25				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		AAAGCTCAAAGATCGCCTGCA	0.368000													27	83					0	0	0.041601	0	0
TET2	54790	broad.mit.edu	37	4	106156496	106156496	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:106156496C>G	ENST00000540549.1	+	3	2257	c.1397C>G	c.(1396-1398)tCt>tGt	p.S466C	TET2_ENST00000413648.2_Missense_Mutation_p.S466C|TET2_ENST00000380013.4_Missense_Mutation_p.S466C|TET2_ENST00000305737.2_Missense_Mutation_p.S466C|TET2_ENST00000394764.1_Missense_Mutation_p.S466C|TET2_ENST00000545826.1_Missense_Mutation_p.S466C|TET2_ENST00000513237.1_Missense_Mutation_p.S487C			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	466					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.S466C(2)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		CCTAATCCATCTACACATGTA	0.458000			"""Mis N, F"""		MDS								13	35					0	0	0.093190	0	0
FRG1B	284802	broad.mit.edu	37	20	29625891	29625891	+	Silent	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr20:29625891C>G	ENST00000278882.3	+	5	515	c.135C>G	c.(133-135)ggC>ggG	p.G45G	FRG1B_ENST00000439954.2_Silent_p.G50G|FRG1B_ENST00000358464.4_Silent_p.G45G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TGAAATCTGGCTATGGAAAAT	0.343000													3	79					0	0	0.021553	0	0
MYCBP2	23077	broad.mit.edu	37	13	77743819	77743819	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr13:77743819G>A	ENST00000407578.2	-	39	6091	c.5825C>T	c.(5824-5826)tCc>tTc	p.S1942F	MYCBP2_ENST00000357337.6_Missense_Mutation_p.S1904F|MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000544440.2_Missense_Mutation_p.S1904F	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1904					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding	p.S1904F(2)|p.S1942F(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AAACAGACTGGAAGAACTCAG	0.383000													18	66					0	0	0.043863	0	0
TRPM4	54795	broad.mit.edu	37	19	49713574	49713574	+	Silent	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:49713574C>T	ENST00000252826.5	+	21	3366	c.3240C>T	c.(3238-3240)atC>atT	p.I1080I	TRPM4_ENST00000427978.2_Silent_p.I935I|TRPM4_ENST00000355712.5_Silent_p.I726I	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	1080	Calmodulin-binding.				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding	p.I1080I(1)		breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CGCCCTTTATCGTCATCTCCC	0.637000													20	30					0	0	0.062417	0	0
C4BPA	722	broad.mit.edu	37	1	207300089	207300089	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:207300089T>A	ENST00000367070.3	+	7	932	c.738T>A	c.(736-738)caT>caA	p.H246Q		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	246	Sushi 4.				complement activation, classical pathway|innate immune response	extracellular region	protein binding	p.H246Q(1)		breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						ATGTTTCACATGGGGAAATGG	0.378000													30	80					0	0	0.069456	0	0
LPAR2	9170	broad.mit.edu	37	19	19737749	19737749	+	Silent	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:19737749G>A	ENST00000542587.1	-	5	1247	c.345C>T	c.(343-345)ctC>ctT	p.L115L	LPAR2_ENST00000586703.1_Silent_p.L115L|LPAR2_ENST00000407877.3_Silent_p.L115L			Q9HBW0	LPAR2_HUMAN	lysophosphatidic acid receptor 2	115					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	cell surface|integral to plasma membrane	LIM domain binding|lipid binding	p.L115L(1)		breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	10						CCGACGCAGTGAGGCTTGTGT	0.672000													6	6					0	0	0.021553	0	0
RTN1	6252	broad.mit.edu	37	14	60212834	60212834	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr14:60212834C>T	ENST00000267484.5	-	2	942	c.607G>A	c.(607-609)Gag>Aag	p.E203K		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	203					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity	p.E203K(1)		central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TTCACCTCCTCGGGTCTGGTT	0.453000													70	138					0	0	0.048971	0	0
ELAVL1	1994	broad.mit.edu	37	19	8046039	8046039	+	Silent	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:8046039G>A	ENST00000407627.2	-	3	333	c.204C>T	c.(202-204)taC>taT	p.Y68Y	ELAVL1_ENST00000351593.5_Silent_p.Y95Y|ELAVL1_ENST00000596459.1_Silent_p.Y68Y|ELAVL1_ENST00000593807.1_Silent_p.Y68Y	NM_001419.2	NP_001410.2	Q15717	ELAV1_HUMAN	ELAV like RNA binding protein 1	68	RRM 1.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding	p.Y68Y(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TCGCGGTCACGTAGTTCACAA	0.532000													14	46					0	0	0.020292	0	0
LPA	4018	broad.mit.edu	37	6	161007642	161007642	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:161007642C>T	ENST00000447678.1	-	26	4088	c.3968G>A	c.(3967-3969)tGc>tAc	p.C1323Y	LPA_ENST00000316300.5_Missense_Mutation_p.C1323Y	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3831	Kringle 12.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity	p.C1323Y(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGGATTCCTGCAGTAGTTCCT	0.483000													19	47					0	0	0.038395	0	0
SLC4A8	9498	broad.mit.edu	37	12	51868256	51868256	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr12:51868256C>G	ENST00000535225.2	+	15	2159	c.1876C>G	c.(1876-1878)Cct>Gct	p.P626A	SLC4A8_ENST00000394856.1_Intron|SLC4A8_ENST00000453097.2_Intron|SLC4A8_ENST00000358657.3_Intron|SLC4A8_ENST00000514353.3_Intron	NM_001258402.1|NM_001267615.1	NP_001245331.1|NP_001254544.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	0					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		TGCCAGATGTCCTAGCATTGT	0.488000													2	8					0	0	0.004672	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144923818	144923818	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:144923818T>C	ENST00000529945.1	-	2	1568	c.1129A>G	c.(1129-1131)Atg>Gtg	p.M377V	PDE4DIP_ENST00000313431.9_Missense_Mutation_p.M377V|PDE4DIP_ENST00000479408.2_Start_Codon_SNP_p.M1V|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.M214V|PDE4DIP_ENST00000369359.4_Missense_Mutation_p.M351V|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.M351V|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.M214V|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.M214V|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.M214V|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.M280V			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	214					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding	p.M214V(2)|p.M377V(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCTTCAGTCATGGGCTAGGAA	0.403000			T	PDGFRB	MPD								19	103					0	0	0.043863	0	0
TPR	7175	broad.mit.edu	37	1	186324850	186324850	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:186324850T>C	ENST00000367478.4	-	16	2235	c.1939A>G	c.(1939-1941)Aca>Gca	p.T647A	TPR_ENST00000474852.1_5'UTR	NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity	p.T647A(1)|p.T648A(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GTCTGTGATGTACTTGGACGT	0.398000			T	NTRK1	papillary thyroid								31	53					0	0	0.041601	0	0
PPIE	10450	broad.mit.edu	37	1	40214727	40214727	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:40214727G>A	ENST00000324379.5	+	8	680	c.661G>A	c.(661-663)Gat>Aat	p.D221N	PPIE_ENST00000372830.1_Missense_Mutation_p.D221N|PPIE_ENST00000470213.1_Missense_Mutation_p.M179I|PPIE_ENST00000356511.2_Missense_Mutation_p.D221N	NM_006112.3	NP_006103.1	Q9UNP9	PPIE_HUMAN	peptidylprolyl isomerase E (cyclophilin E)	221	PPIase cyclophilin-type.				protein folding|regulation of transcription, DNA-dependent	catalytic step 2 spliceosome	cyclosporin A binding|nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|RNA binding	p.D221N(2)		kidney(3)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	9	all_cancers(7;1.63e-13)|all_lung(5;2.27e-16)|all_epithelial(6;1.35e-15)|Lung NSC(20;1.49e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;2.7e-17)|all cancers(16;5.5e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GAAGTTCGATGATGAAAACTT	0.557000													31	32					0	0	0.050027	0	0
IL34	146433	broad.mit.edu	37	16	70693984	70693984	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:70693984C>T	ENST00000429149.2	+	7	1178	c.623C>T	c.(622-624)gCg>gTg	p.A208V	IL34_ENST00000288098.2_Missense_Mutation_p.A208V|IL34_ENST00000566361.1_Missense_Mutation_p.A183V	NM_001172771.1|NM_152456.2	NP_001166242.1|NP_689669.2	Q6ZMJ4	IL34_HUMAN	interleukin 34	208					positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding	p.A208V(1)		breast(1)|central_nervous_system(1)|kidney(9)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(2)	17						TTGCAGTATGCGGCCACCCAG	0.647000													4	123					0	0	0.009096	0	0
KMT2A	4297	broad.mit.edu	37	11	118375131	118375131	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:118375131G>A	ENST00000534358.1	+	27	8547	c.8524G>A	c.(8524-8526)Gat>Aat	p.D2842N	KMT2A_ENST00000354520.4_Missense_Mutation_p.D2801N|KMT2A_ENST00000389506.5_Missense_Mutation_p.D2839N	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A									p.D2842N(1)|p.D2839N(1)									TAACAACAGTGATGACTGTGG	0.448000													37	93					0	0	0.069456	0	0
POTEC	388468	broad.mit.edu	37	18	14513675	14513675	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr18:14513675T>C	ENST00000358970.5	-	10	1518	c.1519A>G	c.(1519-1521)Aaa>Gaa	p.K507E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	507								p.K507E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GAATTCATTTTCTTTTCAGCC	0.284000													3	64					0	0	0.004672	0	0
KMT2A	4297	broad.mit.edu	37	11	118374132	118374132	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:118374132G>A	ENST00000534358.1	+	27	7548	c.7525G>A	c.(7525-7527)Gaa>Aaa	p.E2509K	KMT2A_ENST00000354520.4_Missense_Mutation_p.E2468K|KMT2A_ENST00000389506.5_Missense_Mutation_p.E2506K	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A									p.E2509K(1)|p.E2506K(1)|p.E2509Q(1)|p.E2506Q(1)									CATGCAAGTAGAAGGATCTGC	0.448000													13	31					0	0	0.105934	0	0
SYNPO	11346	broad.mit.edu	37	5	150028061	150028061	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr5:150028061C>T	ENST00000394243.1	+	3	1330	c.956C>T	c.(955-957)tCg>tTg	p.S319L	SYNPO_ENST00000519664.1_Missense_Mutation_p.S75L|SYNPO_ENST00000522122.1_Missense_Mutation_p.S319L|SYNPO_ENST00000307662.4_Missense_Mutation_p.S75L|SYNPO_ENST00000518872.1_Intron	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	319					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding	p.S75L(1)|p.S319L(1)		NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AACCTTGCCTCGCCCAGTGCC	0.607000													44	93					0	0	0.111260	0	0
PPP1R18	170954	broad.mit.edu	37	6	30653297	30653297	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:30653297G>T	ENST00000274853.3	-	1	2375	c.499C>A	c.(499-501)Ctg>Atg	p.L167M	PPP1R18_ENST00000488324.1_Intron|PPP1R18_ENST00000399199.3_Missense_Mutation_p.L167M	NM_133471.3	NP_597728.1	Q6NYC8	PHTNS_HUMAN	protein phosphatase 1, regulatory subunit 18	167						cytoplasm|cytoskeleton	actin binding	p.L167M(1)									CGAGCCTCCAGAGGCCTCAGG	0.602000													65	127					1.40369e-38	1.48221e-38	0.048971	1	0
ARID1A	8289	broad.mit.edu	37	1	27099094	27099097	+	Frame_Shift_Del	DEL	CAGT	CAGT	-			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:27099094_27099097delCAGT	ENST00000324856.7	+	13	3881_3884	c.3510_3513delCAGT	c.(3508-3513)cacagtfs	p.HS1170fs	ARID1A_ENST00000457599.2_Frame_Shift_Del_p.HS1170fs|ARID1A_ENST00000374152.2_Frame_Shift_Del_p.HS787fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1170					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCACACCACACAGTCAGATCCCCC	0.564			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								10	36	---	---	---	---					
ELF3	1999	broad.mit.edu	37	1	201981870	201981871	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:201981870_201981871insT	ENST00000359651.3	+	4	3773_3774	c.581_582insT	c.(580-585)tctgacfs	p.D195fs	ELF3_ENST00000367284.5_Frame_Shift_Ins_p.D195fs|ELF3_ENST00000367283.3_Frame_Shift_Ins_p.D195fs|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	195					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						CCTGGCAGCTCTGACGTCTCCA	0.663													16	31	---	---	---	---					
TSNAX-DISC1	100303453	broad.mit.edu	37	1	231696991	231696995	+	Frame_Shift_Del	DEL	AAAAT	AAAAT	-			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:231696991_231696995delAAAAT	ENST00000602962.1	+	5	643_647	c.485_489delAAAAT	c.(484-489)gaaaatfs	p.EN162fs	TSNAX_ENST00000366639.4_Frame_Shift_Del_p.EN162fs																							AATGGGAAAGAAAATAAAACTGTGA	0.273													10	33	---	---	---	---					
IFIH1	64135	broad.mit.edu	37	2	163174805	163174806	+	Frame_Shift_Ins	INS	-	-	CC			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:163174805_163174806insCC	ENST00000263642.2	-	1	407_408	c.12_13insGG	c.(10-15)gggtatfs	p.Y5fs	IFIH1_ENST00000421365.2_Frame_Shift_Ins_p.Y5fs	NM_022168.3	NP_071451.2	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	5					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	39						TCTGTGGAATACCCATTCGACA	0.530													22	62	---	---	---	---					
HIST1H4L	8368	broad.mit.edu	37	6	27841112	27841114	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:27841112_27841114delAAG	ENST00000355981.2	-	1	175_177	c.175_177delCTT	c.(175-177)cttdel	p.L59del		NM_003546.2	NP_003537.1	P62805	H4_HUMAN	histone cluster 1, H4l	59					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	13						AAAACACTTTAAGAACTCCGCGT	0.552													12	41	---	---	---	---					
GTF2IRD2P1	401375	broad.mit.edu	37	7	72662348	72662349	+	RNA	INS	-	-	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr7:72662348_72662349insA	ENST00000425256.1	-	0	1007																											actctgtctccaaaaaaaaaaa	0.480													2	4	---	---	---	---					
CAMSAP1	157922	broad.mit.edu	37	9	138715799	138715800	+	Frame_Shift_Ins	INS	-	-	T	rs148250832	byFrequency	TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr9:138715799_138715800insT	ENST00000389532.4	-	10	1460_1461	c.1396_1397insA	c.(1396-1398)accfs	p.T466fs	CAMSAP1_ENST00000312405.6_Frame_Shift_Ins_p.T188fs|CAMSAP1_ENST00000409386.3_Frame_Shift_Ins_p.T477fs|CAMSAP1_ENST00000483991.1_5'UTR	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	466						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GACTCACCTGGTTTTTTTTTCT	0.460													2	4	---	---	---	---					
RP11-179A10.1	0	broad.mit.edu	37	11	11158592	11158592	+	RNA	DEL	G	G	-	rs11303970		TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:11158592delG	ENST00000525758.1	+	0	108																											aaaaaaaaaagaaaaaaaaat	0.393													5	7	---	---	---	---					
GPALPP1	55425	broad.mit.edu	37	13	45580365	45580367	+	In_Frame_Del	DEL	GAT	GAT	-	rs138421508		TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr13:45580365_45580367delGAT	ENST00000361121.2	+	3	285_287	c.250_252delGAT	c.(250-252)gatdel	p.D88del	RP11-321C24.1_ENST00000437748.2_lincRNA|GPALPP1_ENST00000379151.4_In_Frame_Del_p.D88del|GPALPP1_ENST00000357537.3_De_novo_Start_InFrame					GPALPP motifs containing 1	88																	Ggatgatgacgatgatgatgatg	0.335													7	329	---	---	---	---					
DHRS7B	25979	broad.mit.edu	37	17	21094331	21094333	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:21094331_21094333delGAA	ENST00000395511.3	+	7	1163_1165	c.843_845delGAA	c.(841-846)gggaag>ggg	p.K285del	DHRS7B_ENST00000581463.1_Intron|DHRS7B_ENST00000579303.1_In_Frame_Del_p.K270del	NM_015510.4	NP_056325.2	Q6IAN0	DRS7B_HUMAN	dehydrogenase/reductase (SDR family) member 7B	285						integral to membrane|peroxisomal membrane	binding|oxidoreductase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|pancreas(2)	7						CTGCTGTGGGGAAGAAGAAGAAA	0.507													11	1646	---	---	---	---					
CASKIN2	57513	broad.mit.edu	37	17	73498817	73498819	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:73498817_73498819delAGG	ENST00000321617.3	-	18	2922_2924	c.2336_2338delCCT	c.(2335-2340)tcctac>tac	p.S779del	CASKIN2_ENST00000433559.2_In_Frame_Del_p.S697del	NM_020753.3	NP_065804.2	Q8WXE0	CSKI2_HUMAN	CASK interacting protein 2	779	Pro-rich.					cytoplasm				endometrium(1)|kidney(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCGGCCAAGTAGGAGAAGGCCCA	0.695													5	9	---	---	---	---					
ANKRD20A11P	391267	broad.mit.edu	37	21	15343608	15343609	+	RNA	INS	-	-	A			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr21:15343608_15343609insA	ENST00000344693.5	-	0	736					NR_027270.1																						TAAAACAGCAGAAAAAATTAAT	0.272													7	90	---	---	---	---					
