Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DCTN4	51164	broad.mit.edu	37	5	150099298	150099298	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:150099298G>A	ENST00000447998.2	-	10	1058	c.943C>T	c.(943-945)Ccc>Tcc	p.P315S	DCTN4_ENST00000424236.1_Missense_Mutation_p.P258S|DCTN4_ENST00000446090.2_Missense_Mutation_p.P322S	NM_016221.3	NP_057305.1	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62)	315						centrosome|nucleus	protein N-terminus binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	10		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGAAGGTTGGGAATTGACATG	0.333000													19	2					0	0	0.575678	0	0
KIF5C	3800	broad.mit.edu	37	2	149861968	149861968	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:149861968G>A	ENST00000435030.1	+	22	2803	c.2435G>A	c.(2434-2436)cGa>cAa	p.R812Q	KIF5C_ENST00000464066.1_3'UTR|KIF5C_ENST00000414838.2_Missense_Mutation_p.R717Q|KIF5C_ENST00000397413.1_Missense_Mutation_p.R580Q			O60282	KIF5C_HUMAN	kinesin family member 5C	812					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		CTGACCACCCGAGTTAAAAAA	0.403000													3	16					0	0	0.115264	0	0
ZBTB12	221527	broad.mit.edu	37	6	31868680	31868680	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:31868680C>G	ENST00000375527.2	-	2	578	c.403G>C	c.(403-405)Gag>Cag	p.E135Q	C2_ENST00000469372.1_Intron	NM_181842.2	NP_862825.1	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)|prostate(1)|skin(1)	10						ACCCCATCCTCTTTGAGGCCT	0.602000													22	48					0	0	0.654019	0	0
NOL6	65083	broad.mit.edu	37	9	33464905	33464905	+	Silent	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:33464905G>C	ENST00000379471.2	-	21	2838	c.2751C>G	c.(2749-2751)ctC>ctG	p.L917L	NOL6_ENST00000464829.1_Intron|NOL6_ENST00000455041.2_Silent_p.L865L			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	917					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GGTTGACAAAGAGGGGGTTGT	0.483000													13	27					0	0	0.500413	0	0
TOB1	10140	broad.mit.edu	37	17	48940765	48940765	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:48940765G>A	ENST00000499247.2	-	2	1047	c.614C>T	c.(613-615)tCt>tTt	p.S205F	TOB1_ENST00000268957.3_Missense_Mutation_p.S205F|TOB1_ENST00000509385.1_5'UTR	NM_001243885.1|NM_005749.3	NP_001230814.1|NP_005740.1	P50616	TOB1_HUMAN	transducer of ERBB2, 1	205					negative regulation of cell proliferation		SH3/SH2 adaptor activity			breast(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GTTGATGGGAGAAGTACGTGC	0.493000													14	72					0	0	0.457914	0	0
MAP3K13	9175	broad.mit.edu	37	3	185181390	185181390	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:185181390G>A	ENST00000265026.3	+	8	1665	c.1331G>A	c.(1330-1332)gGa>gAa	p.G444E	MAP3K13_ENST00000443863.1_Missense_Mutation_p.G300E|MAP3K13_ENST00000424227.1_Missense_Mutation_p.G444E|MAP3K13_ENST00000446828.1_Missense_Mutation_p.G237E|MAP3K13_ENST00000535426.1_Missense_Mutation_p.G300E	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	444	Leucine-zipper 1.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAAAGTGAAGGAACTTGTATA	0.443000													7	74					0	0	0.248553	0	0
PHOX2A	401	broad.mit.edu	37	11	71950871	71950871	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:71950871G>A	ENST00000298231.5	-	3	948	c.777C>T	c.(775-777)tcC>tcT	p.S259S		NM_005169.3	NP_005160.2	O14813	PHX2A_HUMAN	paired-like homeobox 2a	259					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	5						GCCCGGGGCCGGACTCCGCCG	0.726000													11	2					0	0	0.387290	0	0
OR8J3	81168	broad.mit.edu	37	11	55904466	55904466	+	Silent	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:55904466C>A	ENST00000301529.1	-	1	728	c.729G>T	c.(727-729)tcG>tcT	p.S243S		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S243S(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					CTATCATATGCGAAGCGCAGG	0.403000													17	18					1.99824e-07	2.09865e-07	0.520397	1	0
RABGAP1L	9910	broad.mit.edu	37	1	174210653	174210653	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:174210653C>T	ENST00000251507.4	+	5	749	c.575C>T	c.(574-576)gCa>gTa	p.A192V	RABGAP1L_ENST00000357444.6_Missense_Mutation_p.A155V|RABGAP1L_ENST00000367689.3_5'UTR	NM_014857.4	NP_055672.3	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like	192	PID.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			NS(1)|breast(2)|endometrium(4)|kidney(5)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(2)	45						GTGGAGATAGCATCTTTTCCA	0.363000													10	23					0	0	0.411799	0	0
GPR141	353345	broad.mit.edu	37	7	37780343	37780343	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:37780343C>G	ENST00000447769.1	+	4	637	c.348C>G	c.(346-348)atC>atG	p.I116M	EPDR1_ENST00000476620.1_Intron|GPR141_ENST00000334425.1_Missense_Mutation_p.I116M|GPR141_ENST00000461610.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	116						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GATACCTCATCTTCTTCAAGT	0.493000													13	91					0	0	0.479597	0	0
GPR133	283383	broad.mit.edu	37	12	131490586	131490586	+	Missense_Mutation	SNP	A	A	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:131490586A>C	ENST00000261654.5	+	12	1884	c.1325A>C	c.(1324-1326)cAc>cCc	p.H442P	GPR133_ENST00000535015.1_Missense_Mutation_p.H474P|GPR133_ENST00000376682.4_Missense_Mutation_p.H128P	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	442					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGGCCCGCCCACACCAAGTGA	0.647000													23	47					0	0	0.654019	0	0
KCNA6	3742	broad.mit.edu	37	12	4920778	4920778	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:4920778G>C	ENST00000433855.1	+	1	2437	c.1571G>C	c.(1570-1572)aGa>aCa	p.R524T	KCNA6_ENST00000280684.3_Missense_Mutation_p.R524T	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	524						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GCAGAGAAAAGAATGCTCACG	0.562000										HNSCC(72;0.22)			20	66					0	0	0.624587	0	0
FGFR4	2264	broad.mit.edu	37	5	176523291	176523291	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:176523291C>T	ENST00000292408.4	+	15	2193	c.1948C>T	c.(1948-1950)Cgc>Tgc	p.R650C	FGFR4_ENST00000502906.1_Missense_Mutation_p.R650C|FGFR4_ENST00000393637.1_Missense_Mutation_p.R610C|FGFR4_ENST00000393648.2_Missense_Mutation_p.R582C|FGFR4_ENST00000292410.3_Missense_Mutation_p.R610C	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	650	Protein kinase.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CCTCCAGGGCCGCCTGCCTGT	0.672000										TSP Lung(9;0.080)			13	42					0	0	0.500413	0	0
COG3	83548	broad.mit.edu	37	13	46039343	46039343	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:46039343G>A	ENST00000349995.5	+	1	284	c.172G>A	c.(172-174)Gag>Aag	p.E58K		NM_031431.3	NP_113619	Q96JB2	COG3_HUMAN	component of oligomeric golgi complex 3	58					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|skin(2)|stomach(1)	24		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		GGTGCCAGCTGAGGTGAGGTG	0.692000													15	35					0	0	0.520397	0	0
OR5H6	79295	broad.mit.edu	37	3	97983269	97983269	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:97983269C>G	ENST00000383696.2	+	1	182	c.141C>G	c.(139-141)ttC>ttG	p.F47L	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TCCTGGCATTCTTGGTAATAT	0.413000													70	187					0	0	0.870114	0	0
SCN1A	6323	broad.mit.edu	37	2	166850686	166850686	+	Missense_Mutation	SNP	C	C	T	rs121917915		TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:166850686C>T	ENST00000423058.2	-	25	4839	c.4822G>A	c.(4822-4824)Gat>Aat	p.D1608N	SCN1A_ENST00000303395.4_Missense_Mutation_p.D1608N|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.D1597N|SCN1A_ENST00000409050.1_Missense_Mutation_p.D1580N	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1608			D -> Y (in SMEI; dbSNP:rs121917915).			voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	ACCACAAAATCAAAAATATTC	0.318000													5	7					0	0	0.217242	0	0
SDK2	54549	broad.mit.edu	37	17	71386527	71386527	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:71386527C>A	ENST00000392650.3	-	29	4091	c.4091G>T	c.(4090-4092)gGc>gTc	p.G1364V	SDK2_ENST00000388726.3_Missense_Mutation_p.G1364V	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1364	Fibronectin type-III 8.				cell adhesion	integral to membrane		p.G1364V(1)		breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						TGGCTTGAGGCCCGTGGCTGT	0.647000													4	23					0.00909568	0.00927316	0.150653	1	0
ST18	9705	broad.mit.edu	37	8	53084772	53084772	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:53084772T>C	ENST00000276480.7	-	10	1332	c.649A>G	c.(649-651)Aga>Gga	p.R217G		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	217						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TTTGGGACTCTAGGTGGTTTG	0.413000													24	24					0	0	0.654019	0	0
GPR119	139760	broad.mit.edu	37	X	129518617	129518617	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:129518617C>T	ENST00000276218.2	-	1	894	c.805G>A	c.(805-807)Gtg>Atg	p.V269M		NM_178471.2	NP_848566.1	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	269						integral to membrane|plasma membrane	lipid binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(3)|prostate(1)	11						GAGTTGCCCACGCCGAGCAGC	0.577000													63	1					0	0	0.870114	0	0
MYO3A	53904	broad.mit.edu	37	10	26462805	26462805	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:26462805C>T	ENST00000265944.5	+	30	3778	c.3612C>T	c.(3610-3612)ttC>ttT	p.F1204F	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1204					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AGCAAGAATTCTACCTTGTAG	0.423000													9	47					0	0	0.307466	0	0
HDAC5	10014	broad.mit.edu	37	17	42165952	42165952	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:42165952G>A	ENST00000225983.6	-	12	1728	c.1405C>T	c.(1405-1407)Cag>Tag	p.Q469*	HDAC5_ENST00000393622.2_Nonsense_Mutation_p.Q468*|HDAC5_ENST00000336057.5_Nonsense_Mutation_p.Q468*|HDAC5_ENST00000586802.1_Nonsense_Mutation_p.Q468*			Q9UQL6	HDAC5_HUMAN	histone deacetylase 5	468					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		AGTGGGGACTGCCCGTGGAGT	0.652000													3	41					0	0	0.150653	0	0
ANKHD1	54882	broad.mit.edu	37	5	139889761	139889761	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:139889761C>T	ENST00000297183.6	+	22	4223	c.4099C>T	c.(4099-4101)Cgc>Tgc	p.R1367C	ANKHD1_ENST00000360839.2_Missense_Mutation_p.R1367C|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.R1367C	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCAGCATTTCGCAAGGTAAT	0.388000													4	23					0	0	0.184627	0	0
KIF26B	55083	broad.mit.edu	37	1	245849192	245849192	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:245849192G>A	ENST00000366518.4	+	9	1868	c.1764G>A	c.(1762-1764)gcG>gcA	p.A588A	KIF26B_ENST00000407071.2_Silent_p.A969A			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	969	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GCCAAGCAGCGGGGGCAAGCC	0.587000													3	16					0	0	0.150653	0	0
DCST2	127579	broad.mit.edu	37	1	155001803	155001803	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:155001803G>A	ENST00000368424.3	-	8	1306	c.1248C>T	c.(1246-1248)ctC>ctT	p.L416L	DCST2_ENST00000295536.5_Silent_p.L416L	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	416						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCACGAGGAGGAGGTGTCGGA	0.547000													36	94					0	0	0.804634	0	0
LLGL1	3996	broad.mit.edu	37	17	18137636	18137636	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:18137636C>T	ENST00000316843.4	+	7	860	c.764C>T	c.(763-765)tCa>tTa	p.S255L		NM_004140.3	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	255					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					GTGGTCAGCTCACACAGCGAT	0.647000													9	4					0	0	0.307466	0	0
LSM1	27257	broad.mit.edu	37	8	38021254	38021254	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:38021254C>T	ENST00000311351.4	-	4	731	c.336G>A	c.(334-336)ttG>ttA	p.L112L	RP11-90P5.2_ENST00000520598.1_RNA|LSM1_ENST00000522515.1_5'UTR|LSM1_ENST00000520755.1_3'UTR	NM_014462.2	NP_055277.1	O15116	LSM1_HUMAN	LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)	112					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|mRNA processing|RNA splicing, via transesterification reactions	cytosol|nucleus|ribonucleoprotein complex	protein binding|RNA binding			kidney(2)|large_intestine(3)|lung(2)	7	Colorectal(12;0.000442)					CCTGCACTTTCAACTTCTCTG	0.478000													9	31					0	0	0.335167	0	0
FAM73A	374986	broad.mit.edu	37	1	78267138	78267138	+	Silent	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:78267138A>G	ENST00000370791.3	+	3	350	c.318A>G	c.(316-318)ccA>ccG	p.P106P	FAM73A_ENST00000443751.2_Silent_p.P68P	NM_001270384.1|NM_198549.3	NP_001257313.1|NP_940951.1	Q8NAN2	FA73A_HUMAN	family with sequence similarity 73, member A	106						integral to membrane				breast(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	19				Colorectal(170;0.226)		AAATATTACCATGGGAACCAG	0.353000													14	26					0	0	0.435327	0	0
PCNX	22990	broad.mit.edu	37	14	71443817	71443817	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:71443817C>T	ENST00000304743.2	+	6	1209	c.763C>T	c.(763-765)Ctg>Ttg	p.L255L	PCNX_ENST00000238570.5_Silent_p.L255L|PCNX_ENST00000439984.3_Silent_p.L255L	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	255						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TGATCAGTCTCTGTCCAGCGC	0.502000													10	23					0	0	0.335167	0	0
FAM213A	84293	broad.mit.edu	37	10	82187195	82187195	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:82187195C>G	ENST00000372181.1	+	4	989	c.519C>G	c.(517-519)aaC>aaG	p.N173K	FAM213A_ENST00000372188.1_Missense_Mutation_p.N173K|FAM213A_ENST00000372187.5_Missense_Mutation_p.N173K|FAM213A_ENST00000372185.1_Missense_Mutation_p.N162K	NM_001243778.1|NM_001243782.1	NP_001230707.1|NP_001230711.1	Q9BRX8	CJ058_HUMAN	family with sequence similarity 213, member A	173						extracellular region											TCTCTGGAAACCTGGAAGGAG	0.502000													38	27					0	0	0.812448	0	0
TBL1X	6907	broad.mit.edu	37	X	9659696	9659696	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:9659696G>T	ENST00000217964.7	+	8	1334	c.694G>T	c.(694-696)Gag>Tag	p.E232*	TBL1X_ENST00000407597.2_Nonsense_Mutation_p.E232*|TBL1X_ENST00000380961.1_Nonsense_Mutation_p.E181*|TBL1X_ENST00000536365.1_Nonsense_Mutation_p.E181*|TBL1X_ENST00000424279.1_Nonsense_Mutation_p.E181*	NM_005647.3	NP_005638.1	O60907	TBL1X_HUMAN	transducin (beta)-like 1X-linked	232					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|cervix(1)|endometrium(5)|large_intestine(7)|lung(2)|ovary(1)|skin(2)	20		Hepatocellular(5;0.000888)				TCGGGGCCATGAGTCTGAGGT	0.527000													30	5					1.13719e-10	1.23147e-10	0.729181	1	0
DDX54	79039	broad.mit.edu	37	12	113596723	113596723	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:113596723C>G	ENST00000314045.7	-	20	2635	c.2608G>C	c.(2608-2610)Ggt>Cgt	p.G870R	DDX54_ENST00000306014.5_Missense_Mutation_p.G869R|DDX54_ENST00000549271.1_5'UTR|CCDC42B_ENST00000335621.6_3'UTR	NM_001111322.1	NP_001104792.1	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	869					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GAGCGGGCACCCCGGCCGAAG	0.672000													6	34					0	0	0.307466	0	0
ITGBL1	9358	broad.mit.edu	37	13	102106412	102106412	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:102106412G>A	ENST00000376180.3	+	2	496	c.277G>A	c.(277-279)Gag>Aag	p.E93K	ITGBL1_ENST00000545560.2_Intron	NM_001271756.1|NM_004791.1	NP_001258685.1|NP_004782.1	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat domains)	93	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			breast(1)|large_intestine(6)|lung(16)|ovary(1)|prostate(4)|skin(3)	31	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGAGTGCCATGAGTGGGTGTG	0.667000													4	10					0	0	0.248553	0	0
CELF2	10659	broad.mit.edu	37	10	11060098	11060098	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:11060098G>A	ENST00000450189.1	+	1	206	c.46G>A	c.(46-48)Gag>Aag	p.E16K	CELF2_ENST00000379261.4_Intron|CELF2_ENST00000542579.1_Missense_Mutation_p.E16K|CELF2_ENST00000416382.2_Intron	NM_006561.3	NP_006552.3	O95319	CELF2_HUMAN	CUGBP, Elav-like family member 2	0	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	16						CATGATGGTCGAGGGCCGCCT	0.721000													33	97					0	0	0.812448	0	0
LPPR4	9890	broad.mit.edu	37	1	99771891	99771891	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:99771891G>C	ENST00000370185.3	+	7	2114	c.1617G>C	c.(1615-1617)gaG>gaC	p.E539D	LPPR4_ENST00000457765.1_Missense_Mutation_p.E481D|LPPR4_ENST00000370184.1_Missense_Mutation_p.E381D	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		539							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TCCCTGAGGAGACTCAGGAAA	0.557000													40	126					0	0	0.834066	0	0
NGLY1	55768	broad.mit.edu	37	3	25761126	25761126	+	Splice_Site	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:25761126T>C	ENST00000428257.1	-	12	1843	c.1736A>G	c.(1735-1737)gAt>gGt	p.D579G	NGLY1_ENST00000422724.2_3'UTR|NGLY1_ENST00000396649.3_Splice_Site_p.I538V|NGLY1_ENST00000280700.5_Splice_Site_p.D597G|NGLY1_ENST00000467224.1_5'UTR|NGLY1_ENST00000417874.2_Splice_Site_p.D555G	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	597	PAW.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						AAGACTGTTATCTGTTAGAGG	0.343000													19	26					0	0	0.557998	0	0
SPTBN4	57731	broad.mit.edu	37	19	41040194	41040194	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:41040194G>C	ENST00000352632.3	+	20	4389	c.4303G>C	c.(4303-4305)Gac>Cac	p.D1435H	SPTBN4_ENST00000598249.1_Missense_Mutation_p.D1435H|SPTBN4_ENST00000392023.1_Missense_Mutation_p.D111H|SPTBN4_ENST00000338932.3_Missense_Mutation_p.D1435H|SPTBN4_ENST00000392025.1_Missense_Mutation_p.D178H|SPTBN4_ENST00000595535.1_Missense_Mutation_p.D1435H			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1435					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCAGCTGCAAGACGTGGACCC	0.582000													8	46					0	0	0.335167	0	0
SEL1L2	80343	broad.mit.edu	37	20	13847482	13847482	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:13847482A>G	ENST00000284951.5	-	15	1344	c.1270T>C	c.(1270-1272)Tgg>Cgg	p.W424R	SEL1L2_ENST00000378072.5_Missense_Mutation_p.W424R|SEL1L2_ENST00000486903.1_5'UTR			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	424						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						TAATCCTTCCATATTCCAGAG	0.363000													6	61					0	0	0.217242	0	0
CAND1	55832	broad.mit.edu	37	12	67703818	67703818	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:67703818G>T	ENST00000545606.1	+	12	3600	c.3163G>T	c.(3163-3165)Gaa>Taa	p.E1055*		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	1055					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TCTTTACAATGAAACAAAAGT	0.348000													18	47					1.67942e-08	1.78172e-08	0.539581	1	0
ZNF335	63925	broad.mit.edu	37	20	44578441	44578441	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:44578441G>A	ENST00000322927.2	-	24	3767	c.3667C>T	c.(3667-3669)Cag>Tag	p.Q1223*	ZNF335_ENST00000426788.1_Nonsense_Mutation_p.Q1068*	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1223	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				TAGCTCACCTGGTTGTCGGAG	0.562000													7	65					0	0	0.278610	0	0
FARP2	9855	broad.mit.edu	37	2	242373632	242373632	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:242373632C>T	ENST00000264042.3	+	10	1097	c.927C>T	c.(925-927)ttC>ttT	p.F309F	FARP2_ENST00000545004.1_Silent_p.F309F|FARP2_ENST00000373287.4_Silent_p.F309F	NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	309	FERM.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		GTAAGAACTTCTGGAAGATTT	0.398000													27	52					0	0	0.729181	0	0
MYOD1	4654	broad.mit.edu	37	11	17741681	17741681	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:17741681G>C	ENST00000250003.3	+	1	567	c.352G>C	c.(352-354)Gag>Cag	p.E118Q		NM_002478.4	NP_002469.2	P15172	MYOD1_HUMAN	myogenic differentiation 1	118					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	17						CACCATGCGCGAGCGGCGCCG	0.662000													3	5					0	0	0.115264	0	0
PPP3CC	5533	broad.mit.edu	37	8	22332514	22332514	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:22332514G>C	ENST00000240139.5	+	2	424	c.97G>C	c.(97-99)Gag>Cag	p.E33Q	PPP3CC_ENST00000289963.8_Missense_Mutation_p.E33Q|PPP3CC_ENST00000397775.3_Missense_Mutation_p.E33Q|PPP3CC_ENST00000518852.1_Missense_Mutation_p.E33Q	NM_005605.4	NP_005596.2	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma isozyme	33					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		GGAAGTATTTGAGAATGGGAA	0.338000													10	20					0	0	0.361761	0	0
SCN8A	6334	broad.mit.edu	37	12	52200276	52200276	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:52200276G>A	ENST00000354534.6	+	27	5184	c.5006G>A	c.(5005-5007)gGg>gAg	p.G1669E	SCN8A_ENST00000545061.1_Missense_Mutation_p.G1628E	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit						axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TCCATTTTTGGGATGTCCAAT	0.458000													12	90					0	0	0.387290	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17143877	17143877	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:17143877C>T	ENST00000265970.7	-	14	2514	c.2515G>A	c.(2515-2517)Gat>Aat	p.D839N	PIK3C2A_ENST00000531428.1_Intron|PIK3C2A_ENST00000540361.1_Missense_Mutation_p.D459N	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	839					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity	p.D839H(1)		central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	GAAGGAAAATCAACCTTTAAA	0.303000													6	31					0	0	0.248553	0	0
HMGXB4	10042	broad.mit.edu	37	22	35660675	35660675	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:35660675G>C	ENST00000216106.5	+	5	422	c.294G>C	c.(292-294)aaG>aaC	p.K98N	HMGXB4_ENST00000444518.2_5'UTR	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	98					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						AGAAGAAAAAGAAAAAGTCCA	0.438000													24	53					0	0	0.639603	0	0
MTMR3	8897	broad.mit.edu	37	22	30403146	30403146	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:30403146G>C	ENST00000333027.3	+	10	1043	c.715G>C	c.(715-717)Gag>Cag	p.E239Q	MTMR3_ENST00000406629.1_Missense_Mutation_p.E239Q|MTMR3_ENST00000351488.3_Missense_Mutation_p.E239Q|MTMR3_ENST00000401950.2_Missense_Mutation_p.E239Q|MTMR3_ENST00000323630.5_Missense_Mutation_p.E103Q	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	239	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TGGACAGCCAGAGGTTAGCTG	0.537000													16	53					0	0	0.520397	0	0
STT3B	201595	broad.mit.edu	37	3	31638349	31638349	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:31638349C>T	ENST00000295770.2	+	4	980	c.771C>T	c.(769-771)ttC>ttT	p.F257F	STT3B_ENST00000453168.1_3'UTR	NM_178862.1	NP_849193.1	Q8TCJ2	STT3B_HUMAN	STT3B, subunit of the oligosaccharyltransferase complex (catalytic)	257					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			autonomic_ganglia(1)|biliary_tract(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	19						TATCCTATTTCTATATGGTAA	0.313000													13	43					0	0	0.479597	0	0
BMP1	649	broad.mit.edu	37	8	22033756	22033756	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:22033756G>A	ENST00000306385.5	+	3	1033	c.363G>A	c.(361-363)gcG>gcA	p.A121A	BMP1_ENST00000397816.3_Silent_p.A121A|BMP1_ENST00000306349.8_Silent_p.A121A|BMP1_ENST00000523849.1_3'UTR|BMP1_ENST00000397814.3_Silent_p.A121A|BMP1_ENST00000354870.5_Silent_p.A121A	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	121	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GCCGGCGGGCGGCGACGTCCC	0.622000													22	41					0	0	0.654019	0	0
SYNE1	23345	broad.mit.edu	37	6	152461088	152461088	+	Silent	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:152461088G>C	ENST00000367255.5	-	140	26056	c.25455C>G	c.(25453-25455)ctC>ctG	p.L8485L	SYNE1_ENST00000448038.1_Silent_p.L8437L|SYNE1_ENST00000423061.1_Silent_p.L8437L|SYNE1_ENST00000539504.1_Silent_p.L640L|SYNE1_ENST00000354674.4_Silent_p.L663L|SYNE1_ENST00000356820.4_Silent_p.L3009L|SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000341594.5_Silent_p.L8097L|SYNE1_ENST00000265368.4_Silent_p.L8485L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8485					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAGCTACCTTGAGCTTTTTGA	0.587000										HNSCC(10;0.0054)			9	45					0	0	0.307466	0	0
GABRB3	2562	broad.mit.edu	37	15	26792968	26792968	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:26792968A>T	ENST00000541819.2	-	10	1664	c.1562T>A	c.(1561-1563)tTa>tAa	p.L521*	GABRB3_ENST00000545868.1_Nonsense_Mutation_p.L380*|GABRB3_ENST00000311550.5_Nonsense_Mutation_p.L465*|GABRB3_ENST00000400188.3_Nonsense_Mutation_p.L394*|GABRB3_ENST00000299267.4_Nonsense_Mutation_p.L465*			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	465					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CCAGTAAACTAAGTTGAAAAG	0.353000													22	32					0	0	0.624587	0	0
TRPV5	56302	broad.mit.edu	37	7	142626153	142626153	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:142626153C>A	ENST00000265310.1	-	5	898	c.550G>T	c.(550-552)Gag>Tag	p.E184*	TRPV5_ENST00000442623.1_Nonsense_Mutation_p.E184*	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	184					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GCTCCATGCTCAATGAGCAGC	0.612000													12	30					2.23348e-06	2.33399e-06	0.500413	1	0
STRBP	55342	broad.mit.edu	37	9	125898322	125898322	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:125898322G>A	ENST00000447404.2	-	15	2075	c.1771C>T	c.(1771-1773)Cag>Tag	p.Q591*	STRBP_ENST00000348403.5_Nonsense_Mutation_p.Q591*|STRBP_ENST00000360998.3_Nonsense_Mutation_p.Q577*			Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	591					multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(6)|prostate(1)|skin(2)	26						ACTCATACCTGAGGGATAATC	0.378000													8	20					0	0	0.307466	0	0
MTUS2	23281	broad.mit.edu	37	13	29600135	29600135	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:29600135G>A	ENST00000431530.3	+	1	1388	c.1330G>A	c.(1330-1332)Gac>Aac	p.D444N		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	434						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TTCACCAGGTGACAGTCATGT	0.488000													9	44					0	0	0.361761	0	0
ANKRD28	23243	broad.mit.edu	37	3	15720866	15720866	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:15720866C>T	ENST00000399451.2	-	23	2780	c.2413G>A	c.(2413-2415)Gag>Aag	p.E805K	ANKRD28_ENST00000497037.1_5'UTR|ANKRD28_ENST00000383777.1_Missense_Mutation_p.E838K	NM_001195098.1|NM_001195099.1|NM_015199.3	NP_001182027.1|NP_001182028.1|NP_056014.2	O15084	ANR28_HUMAN	ankyrin repeat domain 28	805						nucleoplasm	protein binding			breast(2)|endometrium(1)|large_intestine(2)|prostate(1)	6						ATTAACATCTCAGCAGCACCT	0.378000													43	143					0	0	0.870114	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105900801	105900801	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:105900801G>A	ENST00000393359.2	-	5	1519	c.1093C>T	c.(1093-1095)Cag>Tag	p.Q365*	TGFBRAP1_ENST00000258449.1_Nonsense_Mutation_p.Q365*			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	365					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						TCCAGGAACTGAAGTTGTGCA	0.468000													23	66					0	0	0.693898	0	0
SALL3	27164	broad.mit.edu	37	18	76753543	76753543	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr18:76753543G>A	ENST00000536229.3	+	1	1862	c.1153G>A	c.(1153-1155)Gtg>Atg	p.V385M	SALL3_ENST00000537592.2_Missense_Mutation_p.V518M|SALL3_ENST00000575389.2_Missense_Mutation_p.V518M			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	518					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CAGCAAGCCCGTGCTGCCCAC	0.721000													4	7					0	0	0.184627	0	0
SPEF2	79925	broad.mit.edu	37	5	35709167	35709167	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:35709167T>C	ENST00000440995.2	+	19	2768	c.2768T>C	c.(2767-2769)aTt>aCt	p.I923T	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.I928T|SPEF2_ENST00000509059.1_Missense_Mutation_p.I923T			Q9C093	SPEF2_HUMAN	sperm flagellar 2	928					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAGAAGGAAATTCATCAAAGC	0.423000													6	82					0	0	0.217242	0	0
PARP4	143	broad.mit.edu	37	13	25021310	25021310	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:25021310C>T	ENST00000381989.3	-	26	3234	c.3129G>A	c.(3127-3129)atG>atA	p.M1043I		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1043	VWFA.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity	p.M1043I(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		ATAGCCTGGTCATTTGGTCTT	0.433000													5	41					0	0	0.217242	0	0
MCTP2	55784	broad.mit.edu	37	15	94913372	94913372	+	Silent	SNP	T	T	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:94913372T>G	ENST00000357742.4	+	11	1545	c.1545T>G	c.(1543-1545)gtT>gtG	p.V515V	MCTP2_ENST00000331706.4_Silent_p.V103V|MCTP2_ENST00000557742.1_Silent_p.V103V|MCTP2_ENST00000451018.3_Silent_p.V515V	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	515	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAGTGAAGGTTTTAAAGGCAG	0.373000													7	26					0	0	0.307466	0	0
PDXK	8566	broad.mit.edu	37	21	45170412	45170412	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:45170412G>T	ENST00000291565.4	+	7	679	c.496G>T	c.(496-498)Gag>Tag	p.E166*	PDXK_ENST00000467908.1_Nonsense_Mutation_p.E126*|PDXK_ENST00000468090.1_Nonsense_Mutation_p.E138*	NM_003681.4	NP_003672.1	O00764	PDXK_HUMAN	pyridoxal (pyridoxine, vitamin B6) kinase	166					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	CCACAGCCAGGAGGAAGCCTT	0.652000													6	27					5.18039e-06	5.35991e-06	0.278610	1	0
EMX1	2016	broad.mit.edu	37	2	73160942	73160942	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:73160942G>A	ENST00000258106.6	+	3	1110	c.732G>A	c.(730-732)agG>agA	p.R244R	EMX1_ENST00000394111.5_3'UTR	NM_004097.2	NP_004088.2	Q04741	EMX1_HUMAN	empty spiracles homeobox 1	211						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(2)|lung(3)	6						AGAACCGGAGGACAAAGTACA	0.607000													28	10					0	0	0.706142	0	0
LATS1	9113	broad.mit.edu	37	6	150001017	150001017	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:150001017G>C	ENST00000543571.1	-	5	3134	c.2587C>G	c.(2587-2589)Cag>Gag	p.Q863E	LATS1_ENST00000542747.1_5'UTR|LATS1_ENST00000253339.5_Missense_Mutation_p.Q863E	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	863	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		TTACCACTCTGATAGTACTTA	0.313000													15	21					0	0	0.479597	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													2	14					0	0	0.115264	0	0
BFAR	51283	broad.mit.edu	37	16	14748942	14748942	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:14748942G>A	ENST00000261658.2	+	5	935	c.658G>A	c.(658-660)Gag>Aag	p.E220K	BFAR_ENST00000563971.1_Missense_Mutation_p.E95K|BFAR_ENST00000426842.2_Missense_Mutation_p.E92K	NM_016561.2	NP_057645.1	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	220	SAM.				anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	11						AACTTTGACAGAGGAAGAATT	0.443000													19	101					0	0	0.592651	0	0
FAM189B	10712	broad.mit.edu	37	1	155218018	155218018	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:155218018C>G	ENST00000361361.2	-	11	2165	c.1656G>C	c.(1654-1656)gaG>gaC	p.E552D	FAM189B_ENST00000368368.3_Missense_Mutation_p.E534D|FAM189B_ENST00000350210.2_Missense_Mutation_p.E456D	NM_006589.2	NP_006580.2	P81408	F189B_HUMAN	family with sequence similarity 189, member B	552						integral to membrane	WW domain binding			breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23						GGCGCCGTTTCTCGGCTGACC	0.652000													14	12					0	0	0.479597	0	0
SPHKAP	80309	broad.mit.edu	37	2	228886493	228886493	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:228886493C>T	ENST00000392056.3	-	6	677	c.631G>A	c.(631-633)Gag>Aag	p.E211K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.E211K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	211						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AAGTCTTCCTCGATTGAAGAT	0.468000													26	33					0	0	0.693898	0	0
CYP2F1	1572	broad.mit.edu	37	19	41631523	41631523	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:41631523C>T	ENST00000331105.2	+	9	1350	c.1278C>T	c.(1276-1278)ttC>ttT	p.F426F		NM_000774.3	NP_000765.2	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F, polypeptide 1	426					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(11)|ovary(2)|skin(2)	29						GTCCAGCCTTCATGCCCTTCT	0.527000													10	95					0	0	0.729181	0	0
TTN	7273	broad.mit.edu	37	2	179438341	179438341	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:179438341A>G	ENST00000589042.1	-	326	72742	c.72518T>C	c.(72517-72519)gTa>gCa	p.V24173A	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V21605A|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V15233A|TTN_ENST00000342175.6_Missense_Mutation_p.V15300A|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V22532A|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V15108A|TTN-AS1_ENST00000586707.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22532	Ig-like 121.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTGAGGCTACATTTGTCCA	0.408000													137	51					0	0	0.870114	0	0
FAM71F2	346653	broad.mit.edu	37	7	128317840	128317840	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:128317840G>A	ENST00000480462.1	+	3	694	c.588G>A	c.(586-588)aaG>aaA	p.K196K	FAM71F2_ENST00000477515.1_Intron|FAM71F2_ENST00000460349.1_3'UTR|FAM71F2_ENST00000378704.3_Silent_p.K187K			Q6NXP2	F71F2_HUMAN	family with sequence similarity 71, member F2	196								p.K196N(1)		NS(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(2)	7						TGGTGCCCAAGATGCCCACCA	0.453000													23	21					0	0	0.654019	0	0
USH2A	7399	broad.mit.edu	37	1	215955497	215955497	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:215955497G>A	ENST00000366943.2	-	54	11013	c.10627C>T	c.(10627-10629)Cgt>Tgt	p.R3543C	USH2A_ENST00000307340.3_Missense_Mutation_p.R3543C			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3543	Fibronectin type-III 20.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCCCGAAAACGTTCAATTCCA	0.373000										HNSCC(13;0.011)			6	32					0	0	0.217242	0	0
AAK1	22848	broad.mit.edu	37	2	69759277	69759277	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:69759277C>T	ENST00000409085.4	-	6	928	c.552G>A	c.(550-552)ttG>ttA	p.L184L	AAK1_ENST00000406297.3_Silent_p.L184L|AAK1_ENST00000470281.1_5'UTR|AAK1_ENST00000409068.1_Silent_p.L184L	NM_014911.3	NP_055726	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	184	Protein kinase.					coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)	17						CTCGGTCATGCAAGAGGATGT	0.413000													10	25					0	0	0.335167	0	0
COPB2	9276	broad.mit.edu	37	3	139085454	139085454	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:139085454G>A	ENST00000333188.5	-	15	2021	c.1840C>T	c.(1840-1842)Cca>Tca	p.P614S	COPB2_ENST00000507777.1_Missense_Mutation_p.P585S	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	614					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						TGTTCTTTTGGAATGGTAGGA	0.403000													6	34					0	0	0.248553	0	0
CCNK	8812	broad.mit.edu	37	14	99967695	99967695	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:99967695G>C	ENST00000389879.5	+	6	643	c.520G>C	c.(520-522)Gat>Cat	p.D174H	CCNK_ENST00000557165.1_Intron|CCNK_ENST00000555049.1_Missense_Mutation_p.D174H	NM_001099402.1	NP_001092872.1	O75909	CCNK_HUMAN	cyclin K	174					cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding			NS(1)|endometrium(2)|lung(3)	6		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)				ATTTCTAGGTGATAAAAACAA	0.313000													9	15					0	0	0.335167	0	0
POMGNT2	84892	broad.mit.edu	37	3	43122017	43122017	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:43122017C>A	ENST00000344697.2	-	2	1252	c.907G>T	c.(907-909)Gag>Tag	p.E303*	POMGNT2_ENST00000441964.1_Nonsense_Mutation_p.E303*	NM_032806.5	NP_116195.2			protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)																		AGCTCTGCCTCATTCAGAATG	0.552000													23	80					6.44725e-10	6.94575e-10	0.624587	1	0
OR51S1	119692	broad.mit.edu	37	11	4869844	4869844	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:4869844C>G	ENST00000322101.2	-	1	670	c.595G>C	c.(595-597)Gaa>Caa	p.E199Q	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCCAAGCTTCTGGGCAGGCC	0.542000													29	36					0	0	0.750413	0	0
RSRC2	65117	broad.mit.edu	37	12	123005942	123005942	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:123005942C>G	ENST00000331738.7	-	3	342	c.197G>C	c.(196-198)aGa>aCa	p.R66T	RSRC2_ENST00000354654.2_Missense_Mutation_p.E11Q	NM_023012.5	NP_075388.2	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2	66	Ser-rich.									breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|urinary_tract(2)	24	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		CTCTTTGCTTCTGCTCCGGCT	0.318000													16	32					0	0	0.539581	0	0
YY1AP1	55249	broad.mit.edu	37	1	155646459	155646459	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:155646459C>G	ENST00000368340.5	-	4	726	c.618G>C	c.(616-618)aaG>aaC	p.K206N	YY1AP1_ENST00000368339.5_Missense_Mutation_p.K206N|YY1AP1_ENST00000311573.5_Missense_Mutation_p.K57N|YY1AP1_ENST00000438245.2_Missense_Mutation_p.K68N|YY1AP1_ENST00000359205.5_Missense_Mutation_p.K57N|YY1AP1_ENST00000355499.4_Missense_Mutation_p.K68N|YY1AP1_ENST00000368330.2_Missense_Mutation_p.K68N|YY1AP1_ENST00000404643.1_Missense_Mutation_p.K68N|YY1AP1_ENST00000535662.1_5'UTR|YY1AP1_ENST00000476093.1_5'UTR|YY1AP1_ENST00000405763.3_Missense_Mutation_p.K206N|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000347088.5_Missense_Mutation_p.K68N|YY1AP1_ENST00000407221.1_Missense_Mutation_p.K57N|YY1AP1_ENST00000361831.5_Missense_Mutation_p.K57N|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000295566.4_Missense_Mutation_p.K134N	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					CTGAAGGTTTCTTCATCTTCA	0.458000													18	59					0	0	0.592651	0	0
DCT	1638	broad.mit.edu	37	13	95114290	95114290	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:95114290G>A	ENST00000377028.5	-	5	1430	c.1017C>T	c.(1015-1017)ttC>ttT	p.F339F	DCT_ENST00000446125.1_Silent_p.F339F	NM_001922.3	NP_001913.2	P40126	TYRP2_HUMAN	dopachrome tautomerase	339					epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		AGTTCTGGAAGAAGGGAGGAT	0.448000													12	37					0	0	0.387290	0	0
KLHL40	131377	broad.mit.edu	37	3	42727789	42727789	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:42727789C>T	ENST00000287777.4	+	1	779	c.679C>T	c.(679-681)Cgc>Tgc	p.R227C		NM_152393.2	NP_689606.2			kelch-like family member 40																		CGTGCGCTGCCGCTTGCTGCC	0.706000													7	4					0	0	0.248553	0	0
SCUBE3	222663	broad.mit.edu	37	6	35207570	35207570	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:35207570A>G	ENST00000274938.7	+	8	871	c.871A>G	c.(871-873)Att>Gtt	p.I291V	SCUBE3_ENST00000394681.1_Missense_Mutation_p.I307V	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	291	EGF-like 7; calcium-binding (Potential).				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						CTGTGACCATATTTGCCGCAA	0.463000													3	75					0	0	0.150653	0	0
OSBP	5007	broad.mit.edu	37	11	59376031	59376031	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:59376031C>T	ENST00000263847.1	-	3	1227	c.748G>A	c.(748-750)Gag>Aag	p.E250K		NM_002556.2	NP_002547.1	P22059	OSBP1_HUMAN	oxysterol binding protein	250					lipid transport	Golgi membrane	oxysterol binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TCATTGCTCTCAGCAGGCAAC	0.488000													38	45					0	0	0.812448	0	0
NR4A3	8013	broad.mit.edu	37	9	102590691	102590691	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:102590691C>A	ENST00000330847.1	+	2	444	c.400C>A	c.(400-402)Ccg>Acg	p.P134T	NR4A3_ENST00000395097.2_Missense_Mutation_p.P123T|NR4A3_ENST00000338488.4_Missense_Mutation_p.P123T			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	123					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				AGCCTCCAGCCCGGAGGACGA	0.672000			T	EWSR1	extraskeletal myxoid chondrosarcoma								38	0					1.52319e-26	1.66673e-26	0.840704	1	0
RGPD4	285190	broad.mit.edu	37	2	108487551	108487551	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:108487551G>A	ENST00000408999.3	+	20	3168	c.3091G>A	c.(3091-3093)Gag>Aag	p.E1031K	RGPD4_ENST00000354986.4_Missense_Mutation_p.E1031K	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1031					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						CTATAAGACTGAGGACAGCGA	0.393000													60	148					0	0	0.870114	0	0
CYP46A1	10858	broad.mit.edu	37	14	100157446	100157446	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:100157446T>C	ENST00000261835.3	+	2	252	c.148T>C	c.(148-150)Tgg>Cgg	p.W50R	CYP46A1_ENST00000423126.2_5'UTR	NM_006668.1	NP_006659.1	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	50					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CCCCTGCTTTTGGAAAAAGGA	0.483000													38	58					0	0	0.834066	0	0
FLG	2312	broad.mit.edu	37	1	152286242	152286242	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:152286242C>A	ENST00000368799.1	-	3	1155	c.1120G>T	c.(1120-1122)Gaa>Taa	p.E374*	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	374	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGCCTGTTCATGGGATGAT	0.567000									Ichthyosis				143	385					1.02779e-63	1.13056e-63	0.870114	1	0
FARP2	9855	broad.mit.edu	37	2	242373728	242373728	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:242373728C>G	ENST00000264042.3	+	10	1193	c.1023C>G	c.(1021-1023)ttC>ttG	p.F341L	FARP2_ENST00000545004.1_Missense_Mutation_p.F341L|FARP2_ENST00000373287.4_Missense_Mutation_p.F341L	NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	341					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		GCTCCTCCTTCAGATACAGGT	0.458000													11	23					0	0	0.361761	0	0
SEMA5A	9037	broad.mit.edu	37	5	9190451	9190451	+	Missense_Mutation	SNP	G	G	A	rs141668225		TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:9190451G>A	ENST00000382496.5	-	11	1866	c.1201C>T	c.(1201-1203)Cgc>Tgc	p.R401C		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	401	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TGGGAAAAGCGGCTATTGTCC	0.567000													26	69					0	0	0.693898	0	0
PXDN	7837	broad.mit.edu	37	2	1652232	1652232	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:1652232C>G	ENST00000252804.4	-	17	3370	c.3320G>C	c.(3319-3321)cGg>cCg	p.R1107P		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1107					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ATTCACAATCCGGAAGGGAGA	0.587000													14	22					0	0	0.457914	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351556	89351556	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:89351556C>T	ENST00000301030.4	-	9	1854	c.1394G>A	c.(1393-1395)aGa>aAa	p.R465K	ANKRD11_ENST00000378330.2_Missense_Mutation_p.R465K	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	465						nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCGAACCTCTCTGCCTtttgt	0.502000													7	26					0	0	0.248553	0	0
ANO1	55107	broad.mit.edu	37	11	70007754	70007754	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:70007754G>C	ENST00000355303.5	+	18	2112	c.1807G>C	c.(1807-1809)Gag>Cag	p.E603Q	ANO1_ENST00000398543.2_Missense_Mutation_p.E457Q|ANO1_ENST00000531349.1_Missense_Mutation_p.E312Q|ANO1_ENST00000538023.1_Missense_Mutation_p.E603Q|ANO1_ENST00000530676.1_Missense_Mutation_p.E457Q|ANO1_ENST00000316296.5_Missense_Mutation_p.E545Q	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	603					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						GAAAAGCTTTGAGGAGAGGCT	0.537000													24	93					0	0	0.717897	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432662	73432662	+	Missense_Mutation	SNP	C	C	T	rs146957114		TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:73432662C>T	ENST00000263666.4	-	10	3169	c.3055G>A	c.(3055-3057)Gaa>Aaa	p.E1019K	PDZRN3_ENST00000462146.2_Missense_Mutation_p.E676K|PDZRN3_ENST00000466780.1_Missense_Mutation_p.E676K|PDZRN3_ENST00000479530.1_Missense_Mutation_p.E736K|PDZRN3_ENST00000535920.1_Missense_Mutation_p.E741K	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	1019							ubiquitin-protein ligase activity|zinc ion binding	p.E1019K(1)		breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TGGCTCAGTTCGAGAATGTTC	0.498000													6	315					0	0	0.217242	0	0
PDXK	8566	broad.mit.edu	37	21	45170387	45170387	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:45170387G>A	ENST00000291565.4	+	7	654	c.471G>A	c.(469-471)ctG>ctA	p.L157L	PDXK_ENST00000467908.1_Silent_p.L117L|PDXK_ENST00000468090.1_Silent_p.L129L	NM_003681.4	NP_003672.1	O00764	PDXK_HUMAN	pyridoxal (pyridoxine, vitamin B6) kinase	157					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	CCAGGTTACTGAGTGGCCGGA	0.652000													4	21					0	0	0.217242	0	0
SPACA7	122258	broad.mit.edu	37	13	113052394	113052394	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:113052394G>A	ENST00000375699.3	+	2	262	c.90G>A	c.(88-90)ctG>ctA	p.L30L	SPACA7_ENST00000283550.3_Silent_p.L61L			Q96KW9	SPAC7_HUMAN	sperm acrosome associated 7	61						extracellular region				large_intestine(5)|lung(4)|skin(3)|urinary_tract(1)	13						TTTTAGATCTGAATAAAACAA	0.473000													29	100					0	0	0.760397	0	0
CDH8	1006	broad.mit.edu	37	16	61851482	61851482	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:61851482G>A	ENST00000577390.1	-	7	2132	c.1178C>T	c.(1177-1179)tCa>tTa	p.S393L	CDH8_ENST00000299345.6_Missense_Mutation_p.S393L|CDH8_ENST00000577730.1_Missense_Mutation_p.S393L|CDH8_ENST00000584337.1_Missense_Mutation_p.S393L	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	393	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GTAAGTCGGTGAAGAGAAGAC	0.498000													19	44					0	0	0.575678	0	0
TSC1	7248	broad.mit.edu	37	9	135797300	135797300	+	Missense_Mutation	SNP	C	C	G	rs118203401		TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:135797300C>G	ENST00000298552.3	-	7	790	c.569G>C	c.(568-570)cGc>cCc	p.R190P	TSC1_ENST00000475903.1_5'UTR|TSC1_ENST00000440111.2_Missense_Mutation_p.R190P|TSC1_ENST00000545250.1_Missense_Mutation_p.R139P|TSC1_ENST00000403810.1_Missense_Mutation_p.R190P	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	190			R -> S.		activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		TCCATAAAGGCGATGAAAGAG	0.458000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				32	7					0	0	0.804634	0	0
ATL3	25923	broad.mit.edu	37	11	63438838	63438838	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:63438838G>A	ENST00000332645.4	-	2	125	c.126C>T	c.(124-126)ccC>ccT	p.P42P	ATL3_ENST00000535789.1_5'UTR|ATL3_ENST00000398868.3_5'UTR|ATL3_ENST00000538786.1_Intron			Q6DD88	ATLA3_HUMAN	atlastin GTPase 3	0					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	11						AGAAGCAGCAGGGGTGCAGAG	0.632000													3	4					0	0	0.217242	0	0
FAM83C	128876	broad.mit.edu	37	20	33879831	33879831	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:33879831C>T	ENST00000374408.3	-	1	373	c.277G>A	c.(277-279)Gag>Aag	p.E93K		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	93										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCCTGAGCCTCGCTGAGCTCA	0.662000													11	41					0	0	0.387290	0	0
SNORA71C	677839	broad.mit.edu	37	20	37058338	37058338	+	RNA	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:37058338G>A	ENST00000364642.1	-	0	108					NR_003017.2																						GGGTTTGGAAGAGACAGGAGT	0.577000													18	50					0	0	0.520397	0	0
GBP7	388646	broad.mit.edu	37	1	89598973	89598973	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:89598973C>G	ENST00000294671.2	-	10	1768	c.1630G>C	c.(1630-1632)Gaa>Caa	p.E544Q		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	544						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TTTCTCAGTTCTCTCATATAG	0.448000													33	61					0	0	0.834066	0	0
ACR	49	broad.mit.edu	37	22	51182532	51182532	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:51182532C>T	ENST00000216139.5	+	4	649	c.609C>T	c.(607-609)ctC>ctT	p.L203L		NM_001097.2	NP_001088.2	P10323	ACRO_HUMAN	acrosin	203	Peptidase S1.				acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		GTGTGGATCTCATCGACCTGG	0.567000													43	108					0	0	0.870114	0	0
KMT2C	58508	broad.mit.edu	37	7	151834007	151834007	+	Silent	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:151834007G>C	ENST00000355193.2	-	60	15035	c.14817C>G	c.(14815-14817)ctC>ctG	p.L4939L	KMT2C_ENST00000262189.6_Silent_p.L4882L|KMT2C_ENST00000485655.2_Silent_p.L87L					lysine (K)-specific methyltransferase 2C																		AGTCATAGCAGAGCTGCCCAC	0.473000													18	54					0	0	0.539581	0	0
SORCS3	22986	broad.mit.edu	37	10	106916944	106916944	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:106916944C>T	ENST00000369701.3	+	10	1758	c.1531C>T	c.(1531-1533)Cag>Tag	p.Q511*		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	511						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGTGGACGACCAGGTGAAGAC	0.522000													26	35					0	0	0.693898	0	0
HERC2P2	400322	broad.mit.edu	37	15	23300033	23300033	+	RNA	SNP	T	T	C	rs1058831	by1000genomes	TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:23300033T>C	ENST00000560464.1	-	0	4254																											CGGGAACGGGTGACTGCTTGC	0.592000													5	38					0	0	0.335167	0	0
PDGFB	5155	broad.mit.edu	37	22	39626222	39626222	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:39626222G>A	ENST00000331163.6	-	5	1255	c.468C>T	c.(466-468)atC>atT	p.I156I	PDGFB_ENST00000381551.4_Silent_p.I141I	NM_002608.2	NP_002599.1	P01127	PDGFB_HUMAN	platelet-derived growth factor beta polypeptide	156					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(429)	central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(2)	7	Melanoma(58;0.04)				Becaplermin(DB00102)	GCACAATCTCGATCTTTCTCA	0.582000			T	COL1A1	DFSP								16	37					0	0	0.539581	0	0
VPS13D	55187	broad.mit.edu	37	1	12463960	12463960	+	Silent	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:12463960C>G	ENST00000358136.3	+	63	12094	c.11964C>G	c.(11962-11964)ctC>ctG	p.L3988L	VPS13D_ENST00000356315.4_Silent_p.L3963L|VPS13D_ENST00000496628.1_3'UTR	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3987					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTGAAAATCTCAAAATCAGCA	0.388000													11	30					0	0	0.411799	0	0
SMAP2	64744	broad.mit.edu	37	1	40882742	40882742	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:40882742C>T	ENST00000539317.1	+	9	1091	c.898C>T	c.(898-900)Cag>Tag	p.Q300*		NM_001198980.1	NP_001185909.1	Q8WU79	SMAP2_HUMAN	small ArfGAP2	380	Met-rich.				regulation of ARF GTPase activity	cytoplasm|nucleus	ARF GTPase activator activity|zinc ion binding			central_nervous_system(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(2)|upper_aerodigestive_tract(1)	24	Lung NSC(20;1.56e-05)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.04e-17)			CCAGCCAGCTCAGCAGCTGCA	0.522000													10	27					0	0	0.435327	0	0
CDK19	23097	broad.mit.edu	37	6	110943360	110943360	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:110943360G>A	ENST00000368911.3	-	11	1220	c.1041C>T	c.(1039-1041)gcC>gcT	p.A347A	CDK19_ENST00000413605.2_Silent_p.A223A|CDK19_ENST00000323817.3_Silent_p.A287A	NM_015076.3	NP_055891.1	Q9BWU1	CDK19_HUMAN	cyclin-dependent kinase 19	347							ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)	22						TCTGGCAGCCGGCAAATACAC	0.318000													3	73					0	0	0.150653	0	0
GLYCTK	132158	broad.mit.edu	37	3	52325777	52325777	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:52325777C>G	ENST00000436784.2	+	4	604	c.544C>G	c.(544-546)Ctg>Gtg	p.L182V	GLYCTK_ENST00000477382.1_Intron|GLYCTK_ENST00000471180.1_Missense_Mutation_p.L55V|GLYCTK_ENST00000473032.1_Intron|GLYCTK-AS1_ENST00000493616.1_RNA|GLYCTK_ENST00000461183.1_Missense_Mutation_p.L98V|GLYCTK_ENST00000305690.8_Missense_Mutation_p.L182V|GLYCTK_ENST00000354773.4_Intron			Q8IVS8	GLCTK_HUMAN	glycerate kinase	182					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		GGGTTCAGCTCTGCTGCCTGC	0.577000											OREG0015611	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	83					0	0	0.639603	0	0
CEND1	51286	broad.mit.edu	37	11	788279	788279	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:788279C>T	ENST00000330106.4	-	2	473	c.298G>A	c.(298-300)Ggg>Agg	p.G100R	CEND1_ENST00000524587.1_5'UTR	NM_016564.3	NP_057648.2	Q8N111	CEND_HUMAN	cell cycle exit and neuronal differentiation 1	100						integral to membrane				prostate(1)	1		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCCTCCGCCCCGTCCCCAGGA	0.692000													6	8					0	0	0.217242	0	0
PRAMEF20	645425	broad.mit.edu	37	1	13743051	13743051	+	Silent	SNP	T	T	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:13743051T>A	ENST00000316412.5	+	2	339	c.240T>A	c.(238-240)gcT>gcA	p.A80A	PRAMEF20_ENST00000602960.1_Silent_p.A80A	NM_001099852.1	NP_001093322.1	Q5VT98	PRA20_HUMAN	PRAME family member 20	80										endometrium(1)|kidney(1)|large_intestine(1)|ovary(1)	4	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.5e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000156)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCTTCCAAGCTGTGCTCGATG	0.607000													26	31					0	0	0.693898	0	0
GRM2	2912	broad.mit.edu	37	3	51746586	51746586	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:51746586G>A	ENST00000395052.3	+	3	782	c.548G>A	c.(547-549)cGc>cAc	p.R183H	GRM2_ENST00000475478.1_Intron|GRM2_ENST00000442933.2_Missense_Mutation_p.R183H	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	183					synaptic transmission	integral to plasma membrane		p.R183H(1)		breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TACTTTGCCCGCACAGTGCCT	0.542000													4	177					0	0	0.150653	0	0
ZNF208	7757	broad.mit.edu	37	19	22155504	22155504	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:22155504T>C	ENST00000397126.4	-	4	2480	c.2332A>G	c.(2332-2334)Aaa>Gaa	p.K778E	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCTTCACATTTGTAGGGTTTC	0.368000													3	26					0	0	0.115264	0	0
OTX1	5013	broad.mit.edu	37	2	63282824	63282824	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:63282824C>T	ENST00000282549.2	+	5	714	c.438C>T	c.(436-438)tcC>tcT	p.S146S	OTX1_ENST00000366671.3_Silent_p.S146S	NM_014562.3	NP_055377.1	P32242	OTX1_HUMAN	orthodenticle homeobox 1	146						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Lung NSC(7;0.121)|all_lung(7;0.211)					CCAGCTCTTCCGCCAACCCAG	0.677000													14	22					0	0	0.500413	0	0
ERC2	26059	broad.mit.edu	37	3	56026169	56026169	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:56026169G>A	ENST00000288221.6	-	11	2426	c.2171C>T	c.(2170-2172)gCg>gTg	p.A724V		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	724						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTCCACTTCCGCTTGGGCCTT	0.478000													98	103					0	0	0.870114	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													2	14					0	0	0.115264	0	0
MBD6	114785	broad.mit.edu	37	12	57918191	57918191	+	Silent	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:57918191C>G	ENST00000355673.3	+	3	461	c.105C>G	c.(103-105)ctC>ctG	p.L35L	MBD6_ENST00000431731.2_Silent_p.L35L|MBD6_ENST00000549231.1_3'UTR	NM_052897.3	NP_443129.3	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	35	MBD.					chromosome|nucleus	chromatin binding|DNA binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						GTGCTGTGCTCTACATCAGGT	0.587000													6	41					0	0	0.248553	0	0
EIF3I	8668	broad.mit.edu	37	1	32691917	32691917	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:32691917G>C	ENST00000373586.1	+	5	468	c.396G>C	c.(394-396)caG>caC	p.Q132H	EIF3I_ENST00000471486.1_3'UTR	NM_003757.2	NP_003748.1	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3, subunit I	132						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				ATCCGAGCCAGATTGGTGAGG	0.542000													24	72					0	0	0.667858	0	0
MLEC	9761	broad.mit.edu	37	12	121132930	121132930	+	Silent	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:121132930C>G	ENST00000228506.3	+	4	1052	c.624C>G	c.(622-624)ctC>ctG	p.L208L	MLEC_ENST00000412616.2_Intron	NM_014730.2	NP_055545.1	Q14165	MLEC_HUMAN	malectin	208					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	16						TCTGTGCACTCTACATCATGG	0.498000													27	231					0	0	0.667858	0	0
EIF3I	8668	broad.mit.edu	37	1	32692108	32692108	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:32692108G>C	ENST00000373586.1	+	6	577	c.505G>C	c.(505-507)Gag>Cag	p.E169Q	EIF3I_ENST00000471486.1_3'UTR	NM_003757.2	NP_003748.1	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3, subunit I	169						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				TGAGAGTGGAGAGCTCAACCA	0.473000													52	155					0	0	0.870114	0	0
MAN1C1	57134	broad.mit.edu	37	1	25944326	25944326	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:25944326C>T	ENST00000374332.4	+	1	368	c.38C>T	c.(37-39)tCc>tTc	p.S13F		NM_020379.2	NP_065112.1	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	13					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(7)|pancreas(1)|prostate(1)|skin(2)	25		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		GTCCCGGCCTCCCCGTGGGGG	0.701000													10	14					0	0	0.387290	0	0
STK10	6793	broad.mit.edu	37	5	171472003	171472003	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:171472003C>G	ENST00000176763.5	-	19	3133	c.2790G>C	c.(2788-2790)caG>caC	p.Q930H		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	930							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCCGCTTCTTCTGGTTCAGAT	0.587000													13	35					0	0	0.435327	0	0
CDK15	65061	broad.mit.edu	37	2	202698639	202698639	+	Silent	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:202698639G>C	ENST00000450471.2	+	7	761	c.675G>C	c.(673-675)ctG>ctC	p.L225L	CDK15_ENST00000434439.1_Silent_p.L225L|CDK15_ENST00000260967.2_Silent_p.L174L|CDK15_ENST00000374598.4_Silent_p.L225L|CDK15_ENST00000488419.1_3'UTR|CDK15_ENST00000410091.3_Silent_p.L174L	NM_001261435.1	NP_001248364.1	Q96Q40	CDK15_HUMAN	cyclin-dependent kinase 15	225	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(3)|endometrium(2)|kidney(5)|large_intestine(1)|lung(14)|ovary(1)	26					Adenosine triphosphate(DB00171)	ACAGGGACCTGAAACCTCAGA	0.493000													27	55					0	0	0.750413	0	0
STAG3L1	54441	broad.mit.edu	37	7	75023531	75023531	+	RNA	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:75023531C>T	ENST00000402225.5	+	0	811				AC006014.8_ENST00000275590.5_RNA			P0CL83	ST3L1_HUMAN								nucleus	binding										AGCTCCTACTCTGAATTTACC	0.458000													5	17					0	0	0.335167	0	0
ROBO1	6091	broad.mit.edu	37	3	78666910	78666910	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:78666910C>T	ENST00000436010.2	-	25	5037	c.4040G>A	c.(4039-4041)gGa>gAa	p.G1347E	ROBO1_ENST00000495273.1_Missense_Mutation_p.G1341E|ROBO1_ENST00000464233.1_Missense_Mutation_p.G1386E|ROBO1_ENST00000467549.1_Missense_Mutation_p.G1286E			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1386					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ACTGGAGCGTCCGCTGGAAAT	0.577000													9	30					0	0	0.335167	0	0
SLC1A4	6509	broad.mit.edu	37	2	65245358	65245358	+	Silent	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:65245358C>G	ENST00000234256.3	+	6	1431	c.1188C>G	c.(1186-1188)ctC>ctG	p.L396L	SLC1A4_ENST00000531327.1_Silent_p.L98L	NM_003038.4	NP_003029.2	P43007	SATT_HUMAN	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	396					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|urinary_tract(1)	13					L-Alanine(DB00160)	TTGCGCAACTCAACAACGTAG	0.498000													11	96					0	0	0.411799	0	0
AHDC1	27245	broad.mit.edu	37	1	27876618	27876618	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:27876618C>T	ENST00000374011.2	-	6	2977	c.2009G>A	c.(2008-2010)gGc>gAc	p.G670D	AHDC1_ENST00000247087.5_Missense_Mutation_p.G670D	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	670	Gly-rich.						DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GCCTGCTTTGCCCCCACGCCG	0.642000													3	50					0	0	0.150653	0	0
CHRM1	1128	broad.mit.edu	37	11	62677566	62677566	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:62677566C>T	ENST00000306960.3	-	2	1548	c.1007G>A	c.(1006-1008)cGa>cAa	p.R336Q	AP000438.2_ENST00000543624.1_RNA	NM_000738.2	NP_000729.2	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	336					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding			large_intestine(5)|lung(3)|stomach(1)	9					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	CTTGCCAGCTCGATCACGCCC	0.627000													12	15					0	0	0.435327	0	0
SCN8A	6334	broad.mit.edu	37	12	52200727	52200727	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:52200727C>T	ENST00000354534.6	+	27	5635	c.5457C>T	c.(5455-5457)ctC>ctT	p.L1819L	SCN8A_ENST00000545061.1_Silent_p.L1778L	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit						axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AGCATCCTCTCCGAGTGCCCA	0.527000													42	47					0	0	0.834066	0	0
MECOM	2122	broad.mit.edu	37	3	169099220	169099220	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:169099220G>A	ENST00000494292.1	-	2	227	c.130C>T	c.(130-132)Caa>Taa	p.Q44*	MECOM_ENST00000485957.1_5'UTR	NM_004991.3	NP_004982.2	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	44							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						CATGGCTCTTGAATATTGAGG	0.473000													4	35					0	0	0.150653	0	0
ADARB2	105	broad.mit.edu	37	10	1405390	1405390	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:1405390G>A	ENST00000381312.1	-	3	1235	c.910C>T	c.(910-912)Cgg>Tgg	p.R304W		NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	304	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		ACGAAGCTCCGCGCGCGCCGC	0.756000													7	7					0	0	0.278610	0	0
CCT8	10694	broad.mit.edu	37	21	30435690	30435690	+	Silent	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:30435690A>G	ENST00000286788.4	-	8	1130	c.924T>C	c.(922-924)taT>taC	p.Y308Y	CCT8_ENST00000470450.1_5'UTR|CCT8_ENST00000542732.1_Silent_p.Y289Y|CCT8_ENST00000540844.1_Silent_p.Y235Y	NM_006585.2	NP_006576.2	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	308					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|prostate(3)	14						ACATGATATTATATTTATTTG	0.348000													25	32					0	0	0.693898	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072820	17072820	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:17072820C>T	ENST00000359963.3	-	1	880	c.621G>A	c.(619-621)gcG>gcA	p.A207A		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	207					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity	p.A207A(2)		breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCCCGGGCAGCGCGCACACCC	0.617000													37	63					0	0	0.812448	0	0
ATRX	546	broad.mit.edu	37	X	76939532	76939532	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:76939532G>C	ENST00000373344.5	-	9	1430	c.1216C>G	c.(1216-1218)Cat>Gat	p.H406D	ATRX_ENST00000395603.3_Missense_Mutation_p.H368D|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.3	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	406					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	AATGCAAGATGAGCCTTCTTA	0.358000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						71	87					0	0	0.870114	0	0
MBOAT7	79143	broad.mit.edu	37	19	54692145	54692145	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:54692145G>A	ENST00000431666.2	-	3	679	c.40C>T	c.(40-42)Cac>Tac	p.H14Y	MBOAT7_ENST00000391754.1_Silent_p.F44F|MBOAT7_ENST00000474910.1_5'UTR|MBOAT7_ENST00000338624.6_Missense_Mutation_p.H14Y|MBOAT7_ENST00000245615.1_Silent_p.F44F	NM_001146083.1	NP_001139555.1	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	0					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGCCACAGGTGAACAGGGTGA	0.627000													15	44					0	0	0.457914	0	0
TTN	7273	broad.mit.edu	37	2	179456530	179456530	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:179456530C>A	ENST00000589042.1	-	303	60240	c.60016G>T	c.(60016-60018)Ggt>Tgt	p.G20006C	TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G17438C|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G11066C|TTN_ENST00000342175.6_Missense_Mutation_p.G11133C|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G18365C|TTN_ENST00000460472.2_Missense_Mutation_p.G10941C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18365	Fibronectin type-III 44.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTGGAGAACCACCATCACGA	0.458000													7	24					0.0381472	0.0387028	0.278610	1	0
TBCE	6905	broad.mit.edu	37	1	235577915	235577915	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:235577915C>G	ENST00000543662.1	+	4	459	c.353C>G	c.(352-354)tCt>tGt	p.S118C	TBCE_ENST00000406207.1_Missense_Mutation_p.S118C|TBCE_ENST00000366601.3_Missense_Mutation_p.S118C|TBCE_ENST00000472011.1_3'UTR			Q15813	TBCE_HUMAN	tubulin folding cofactor E	118					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding			NS(1)|endometrium(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	14	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			GGTTTTGACTCTATTATGAAA	0.358000													15	20					0	0	0.500413	0	0
PLEKHA5	54477	broad.mit.edu	37	12	19473505	19473505	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:19473505G>C	ENST00000538714.1	+	15	2033	c.2029G>C	c.(2029-2031)Gat>Cat	p.D677H	PLEKHA5_ENST00000429027.2_Missense_Mutation_p.D722H|PLEKHA5_ENST00000359180.3_Missense_Mutation_p.D619H|PLEKHA5_ENST00000355397.3_Missense_Mutation_p.D677H|PLEKHA5_ENST00000299275.6_Missense_Mutation_p.D619H|PLEKHA5_ENST00000539256.1_Missense_Mutation_p.D377H|PLEKHA5_ENST00000424268.1_Missense_Mutation_p.D550H|PLEKHA5_ENST00000317589.4_Missense_Mutation_p.D619H|PLEKHA5_ENST00000543806.1_Missense_Mutation_p.D538H	NM_001143821.2	NP_001137293.2	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A member 5	665							1-phosphatidylinositol binding|protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GCTGTCACAAGATGAAGGTAG	0.264000													14	126					0	0	0.435327	0	0
MROH8	140699	broad.mit.edu	37	20	35766314	35766314	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:35766314G>A	ENST00000400441.3	-	13	1547	c.1548C>T	c.(1546-1548)gtC>gtT	p.V516V	MROH8_ENST00000441008.2_Silent_p.V502V|MROH8_ENST00000217333.8_Silent_p.V345V					maestro heat-like repeat family member 8																		TTTGTTGGCGGACTCTAGGCT	0.408000													5	16					0	0	0.184627	0	0
B4GALNT4	338707	broad.mit.edu	37	11	380870	380870	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:380870C>G	ENST00000329962.6	+	19	2915	c.2915C>G	c.(2914-2916)tCg>tGg	p.S972W		NM_178537.4	NP_848632.2	Q76KP1	B4GN4_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 4	972						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATCTACAAGTCGGACTTTGAC	0.612000													9	19					0	0	0.307466	0	0
CARF	79800	broad.mit.edu	37	2	203831743	203831743	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:203831743G>A	ENST00000402905.3	+	9	1196	c.875G>A	c.(874-876)aGa>aAa	p.R292K	CARF_ENST00000414439.1_Missense_Mutation_p.R190K|CARF_ENST00000545262.1_Missense_Mutation_p.R216K|CARF_ENST00000428585.1_Missense_Mutation_p.R216K|CARF_ENST00000320443.8_Missense_Mutation_p.R292K|WDR12_ENST00000477723.1_Intron|CARF_ENST00000456821.2_3'UTR|CARF_ENST00000438828.2_Missense_Mutation_p.R292K|CARF_ENST00000545253.1_Missense_Mutation_p.R204K	NM_001104586.1|NM_001282910.1|NM_001282911.1|NM_001282912.1	NP_001098056.1|NP_001269839.1|NP_001269840.1|NP_001269841.1			calcium responsive transcription factor																		GGGCCAAGAAGAAAAGGTTTC	0.408000													27	59					0	0	0.740014	0	0
PXDN	7837	broad.mit.edu	37	2	1652231	1652231	+	Silent	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:1652231C>A	ENST00000252804.4	-	17	3371	c.3321G>T	c.(3319-3321)cgG>cgT	p.R1107R		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1107					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CATTCACAATCCGGAAGGGAG	0.587000													13	21					1.5842e-08	1.68927e-08	0.435327	1	0
MAGEC1	9947	broad.mit.edu	37	X	140993970	140993970	+	Silent	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:140993970T>C	ENST00000285879.4	+	4	1066	c.780T>C	c.(778-780)ttT>ttC	p.F260F	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	260							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					AGAGTACTTTTGAGGGTTTTG	0.498000										HNSCC(15;0.026)			5	87					0	0	0.217242	0	0
CECR2	27443	broad.mit.edu	37	22	17976471	17976471	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:17976471C>T	ENST00000400573.5	+	3	199	c.192C>T	c.(190-192)atC>atT	p.I64I	CECR2_ENST00000262608.8_Silent_p.I45I|CECR2_ENST00000400585.2_5'UTR|CECR2_ENST00000497534.1_3'UTR|CECR2_ENST00000342247.5_Silent_p.I44I			Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2						chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		AGGACATCATCAACTACCGCT	0.522000													4	22					0	0	0.150653	0	0
POGK	57645	broad.mit.edu	37	1	166819004	166819004	+	Silent	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:166819004G>C	ENST00000367875.1	+	5	1548	c.1188G>C	c.(1186-1188)ctG>ctC	p.L396L	POGK_ENST00000367876.4_Silent_p.L396L|POGK_ENST00000536514.1_Silent_p.L311L|POGK_ENST00000537173.1_Silent_p.L278L			Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	396	DDE.				multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	22						GGGAAAAACTGAAAATCACAG	0.498000													12	34					0	0	0.411799	0	0
VPS53	55275	broad.mit.edu	37	17	465901	465901	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:465901G>A	ENST00000437048.2	-	14	1544	c.1398C>T	c.(1396-1398)gcC>gcT	p.A466A	VPS53_ENST00000446250.2_Silent_p.A268A|VPS53_ENST00000291074.5_Silent_p.A437A|VPS53_ENST00000574029.1_Intron|VPS53_ENST00000401468.3_Silent_p.A189A|VPS53_ENST00000576149.1_5'UTR|VPS53_ENST00000571805.1_Silent_p.A466A	NM_001128159.2	NP_001121631.1	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 homolog (S. cerevisiae)	466				A -> T (in Ref. 2; AAK27973).	protein transport	endosome membrane|Golgi apparatus				breast(1)|endometrium(4)|large_intestine(5)|lung(8)|prostate(1)	19				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		TGGGGAGCACGGCACCCCCTT	0.552000													23	5					0	0	0.667858	0	0
TRIM71	131405	broad.mit.edu	37	3	32932410	32932410	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:32932410G>C	ENST00000383763.5	+	4	1777	c.1714G>C	c.(1714-1716)Gag>Cag	p.E572Q		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase						multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CCAGCACATTGAGAACAGCCC	0.582000													21	86					0	0	0.608945	0	0
TMEM71	137835	broad.mit.edu	37	8	133726281	133726281	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:133726281G>C	ENST00000356838.3	-	9	917	c.775C>G	c.(775-777)Ctc>Gtc	p.L259V	TMEM71_ENST00000377901.4_Missense_Mutation_p.L215V|TMEM71_ENST00000523829.1_Intron	NM_144649.2	NP_653250.2	Q6P5X7	TMM71_HUMAN	transmembrane protein 71	278						integral to membrane				endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GCAAGGCTGAGAAACAATGAT	0.363000													4	34					0	0	0.184627	0	0
CLCNKB	1188	broad.mit.edu	37	1	16375547	16375547	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:16375547G>A	ENST00000375667.3	+	1	264	c.81G>A	c.(79-81)tgG>tgA	p.W27*	CLCNKB_ENST00000375679.4_Intron	NM_001165945.2	NP_001159417.2			chloride channel, voltage-sensitive Kb											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		AGGTGACATGGGGAGGGGGTC	0.672000													3	46					0	0	0.150653	0	0
ZNF829	374899	broad.mit.edu	37	19	37383084	37383084	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:37383084C>G	ENST00000520965.1	-	6	918	c.852G>C	c.(850-852)caG>caC	p.Q284H	ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000432005.2_Intron|ZNF829_ENST00000391711.3_Missense_Mutation_p.Q203H	NM_001171979.1	NP_001165450.1	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTGAATCCTCTGATGTCGAG	0.383000													14	43					0	0	0.479597	0	0
FBXO42	54455	broad.mit.edu	37	1	16641859	16641859	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:16641859C>G	ENST00000375592.3	-	2	271	c.55G>C	c.(55-57)Gaa>Caa	p.E19Q	FBXO42_ENST00000478089.1_5'UTR	NM_018994.1	NP_061867.1	Q6P3S6	FBX42_HUMAN	F-box protein 42	19										autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	26		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		AGCACAGTTTCTTCCTGGTCC	0.483000													12	28					0	0	0.435327	0	0
ASB17	127247	broad.mit.edu	37	1	76397769	76397769	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:76397769A>G	ENST00000284142.6	-	1	347	c.208T>C	c.(208-210)Tac>Cac	p.Y70H		NM_080868.2	NP_543144.1	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box containing 17	70					intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	21						AATGCAATGTAATCTGTGAGT	0.388000													11	61					0	0	0.435327	0	0
CCDC65	85478	broad.mit.edu	37	12	49315100	49315100	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:49315100C>G	ENST00000266984.5	+	8	1556	c.1329C>G	c.(1327-1329)atC>atG	p.I443M	RP11-302B13.5_ENST00000398092.4_Intron|CCDC65_ENST00000320516.4_Missense_Mutation_p.I443M			Q8IXS2	CCD65_HUMAN	coiled-coil domain containing 65	443										breast(1)|large_intestine(4)|lung(7)|ovary(1)|skin(2)	15						TGGATGGCATCTCAGTGAGTG	0.498000													14	49					0	0	0.479597	0	0
ZCWPW2	152098	broad.mit.edu	37	3	28520378	28520378	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:28520378C>G	ENST00000383768.2	+	5	754	c.566C>G	c.(565-567)tCt>tGt	p.S189C	ZCWPW2_ENST00000421010.1_Missense_Mutation_p.S189C			Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	189							zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(6)|ovary(2)	17						TATGGATATTCTCATGAGCAA	0.294000													7	40					0	0	0.307466	0	0
KRT37	8688	broad.mit.edu	37	17	39580632	39580632	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:39580632G>A	ENST00000225550.3	-	1	143	c.144C>T	c.(142-144)aaC>aaT	p.N48N	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	48	Head.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				CGTGTGCCACGTTGGCCAAGA	0.617000													4	92					0	0	0.150653	0	0
PPP1R3B	79660	broad.mit.edu	37	8	8998846	8998846	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:8998846C>G	ENST00000310455.3	-	2	466	c.316G>C	c.(316-318)Gag>Cag	p.E106Q	PPP1R3B_ENST00000519699.1_Missense_Mutation_p.E106Q	NM_001201329.1|NM_024607.3	NP_001188258.1|NP_078883.2	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory subunit 3B	106					glycogen metabolic process					endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	12				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		CTCTCGCTCTCTGCTGTCGTC	0.483000													33	58					0	0	0.760397	0	0
ZKSCAN7	55888	broad.mit.edu	37	3	44612265	44612265	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:44612265G>A	ENST00000273320.3	+	6	2092	c.1663G>A	c.(1663-1665)Gaa>Aaa	p.E555K	RP11-944L7.5_ENST00000419137.1_Intron|ZKSCAN7_ENST00000426540.1_Missense_Mutation_p.E555K|ZKSCAN7_ENST00000431636.1_Intron|RP11-944L7.4_ENST00000457331.1_RNA|ZKSCAN7_ENST00000341840.3_Intron	NM_018651.2	NP_061121.2			zinc finger with KRAB and SCAN domains 7																		TGAGTGTAGTGAATGTGGCAA	0.438000													13	82					0	0	0.411799	0	0
PGLYRP4	57115	broad.mit.edu	37	1	153309655	153309655	+	Splice_Site	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:153309655A>G	ENST00000368739.3	-	8	1290		c.e8+1		PGLYRP4_ENST00000359650.5_Splice_Site			Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein 4						defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	23	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCATCCACTTACCTGTGAAGG	0.507000													46	31					0	0	0.870114	0	0
TM6SF1	53346	broad.mit.edu	37	15	83776474	83776474	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:83776474C>T	ENST00000322019.9	+	1	316	c.42C>T	c.(40-42)ctC>ctT	p.L14L	TM6SF1_ENST00000565774.1_Silent_p.L14L|TM6SF1_ENST00000564988.1_3'UTR|TM6SF1_ENST00000379386.4_Silent_p.L14L|TM6SF1_ENST00000379390.6_Silent_p.L14L			Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1	14						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						TGCTGTCCCTCTCGGCCATCC	0.736000													6	12					0	0	0.217242	0	0
ARID1A	8289	broad.mit.edu	37	1	27099981	27099981	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:27099981G>C	ENST00000324856.7	+	15	4231	c.3860G>C	c.(3859-3861)aGa>aCa	p.R1287T	ARID1A_ENST00000540690.1_5'UTR|ARID1A_ENST00000457599.2_Missense_Mutation_p.R1287T|ARID1A_ENST00000374152.2_Missense_Mutation_p.R904T	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1287					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Y1285fs*2(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCTTATGACAGAGTGAGGTAA	0.582000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								5	19					0	0	0.184627	0	0
ZMYND8	23613	broad.mit.edu	37	20	45850114	45850114	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:45850114G>A	ENST00000311275.7	-	20	3461	c.3208C>T	c.(3208-3210)Cag>Tag	p.Q1070*	ZMYND8_ENST00000352431.2_Nonsense_Mutation_p.Q1044*|ZMYND8_ENST00000446994.2_Nonsense_Mutation_p.Q961*|ZMYND8_ENST00000458360.2_Nonsense_Mutation_p.Q938*|ZMYND8_ENST00000372023.3_Nonsense_Mutation_p.Q992*|ZMYND8_ENST00000471951.2_Nonsense_Mutation_p.Q1090*|ZMYND8_ENST00000536340.1_Nonsense_Mutation_p.Q1097*|ZMYND8_ENST00000355972.4_Nonsense_Mutation_p.Q1070*|ZMYND8_ENST00000540497.1_Nonsense_Mutation_p.Q1018*|ZMYND8_ENST00000262975.4_Nonsense_Mutation_p.Q1024*|ZMYND8_ENST00000461685.1_Nonsense_Mutation_p.Q1044*|ZMYND8_ENST00000396281.4_Nonsense_Mutation_p.Q1070*|ZMYND8_ENST00000360911.3_Nonsense_Mutation_p.Q1019*	NM_001281772.1|NM_001281778.1|NM_001281783.1	NP_001268701.1|NP_001268707.1|NP_001268712.1	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	1070							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GCTTCCTGCTGAGGAGCAGTA	0.547000													7	25					0	0	0.248553	0	0
HTRA3	94031	broad.mit.edu	37	4	8307709	8307709	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr4:8307709A>G	ENST00000307358.2	+	9	1412	c.1208A>G	c.(1207-1209)cAa>cGa	p.Q403R		NM_053044.3	NP_444272.1	P83110	HTRA3_HUMAN	HtrA serine peptidase 3	403	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|prostate(1)|urinary_tract(1)	18						GGCGGCATCCAAGATGGTGAC	0.647000													4	79					0	0	0.184627	0	0
HDAC11	79885	broad.mit.edu	37	3	13544448	13544448	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:13544448G>A	ENST00000295757.3	+	8	800	c.617G>A	c.(616-618)cGc>cAc	p.R206H	HDAC11_ENST00000402259.1_Intron|HDAC11_ENST00000402271.1_Missense_Mutation_p.R127H|HDAC11_ENST00000433119.1_Missense_Mutation_p.A164T|HDAC11_ENST00000404548.1_Intron|HDAC11_ENST00000437379.2_Missense_Mutation_p.R178H|HDAC11_ENST00000522202.1_Missense_Mutation_p.R155H|HDAC11_ENST00000446613.2_Missense_Mutation_p.R14H|HDAC11_ENST00000405025.1_Intron|HDAC11_ENST00000404040.1_Missense_Mutation_p.R106H|HDAC11_ENST00000495099.2_3'UTR	NM_024827.3	NP_079103.2	Q96DB2	HDA11_HUMAN	histone deacetylase 11	206	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(4)|prostate(3)	13						GTCTACAACCGCCACATCTAC	0.577000													25	210					0	0	0.693898	0	0
PRODH	5625	broad.mit.edu	37	22	18918708	18918708	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:18918708G>A	ENST00000357068.6	-	2	542	c.277C>T	c.(277-279)Ctg>Ttg	p.L93L	PRODH_ENST00000334029.2_5'UTR|PRODH_ENST00000420436.1_Intron	NM_016335.4	NP_057419	O43272	PROD_HUMAN	proline dehydrogenase (oxidase) 1	93					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)|endometrium(3)|lung(4)|upper_aerodigestive_tract(1)	9					L-Proline(DB00172)	GAAACATACAGCAGCTGAAAG	0.547000													13	33					0	0	0.457914	0	0
LIMK1	3984	broad.mit.edu	37	7	73513430	73513430	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:73513430C>T	ENST00000418310.1	+	5	662	c.560C>T	c.(559-561)tCc>tTc	p.S187F	LIMK1_ENST00000538333.3_Missense_Mutation_p.S123F|LIMK1_ENST00000336180.2_Missense_Mutation_p.S157F|LIMK1_ENST00000491052.1_3'UTR			P53667	LIMK1_HUMAN	LIM domain kinase 1	157	PDZ.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				TCCCCTGGCTCCCACCTGCCC	0.647000													53	226					0	0	0.870114	0	0
KDM3A	55818	broad.mit.edu	37	2	86678259	86678259	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:86678259G>A	ENST00000409556.1	+	5	741	c.376G>A	c.(376-378)Gga>Aga	p.G126R	KDM3A_ENST00000542128.1_Missense_Mutation_p.G74R|KDM3A_ENST00000409064.1_Missense_Mutation_p.G126R|KDM3A_ENST00000312912.5_Missense_Mutation_p.G126R			Q9Y4C1	KDM3A_HUMAN	lysine (K)-specific demethylase 3A	126					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(3)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(3)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	47						AGCTGGTTTGGGATCCATAAC	0.368000													31	7					0	0	0.812448	0	0
NLRP8	126205	broad.mit.edu	37	19	56466904	56466904	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:56466904C>T	ENST00000291971.3	+	3	1551	c.1480C>T	c.(1480-1482)Cgg>Tgg	p.R494W	NLRP8_ENST00000590542.1_Missense_Mutation_p.R494W	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	494	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGTATTCTTCGGAGAATTGC	0.468000													14	159					0	0	0.457914	0	0
STUB1	10273	broad.mit.edu	37	16	732417	732417	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:732417C>T	ENST00000565677.1	+	7	1231	c.624C>T	c.(622-624)ctC>ctT	p.L208L	JMJD8_ENST00000454700.1_3'UTR|JMJD8_ENST00000412368.2_3'UTR|STUB1_ENST00000564370.1_Silent_p.L208L|STUB1_ENST00000219548.4_Silent_p.L280L|JMJD8_ENST00000293882.4_3'UTR|JMJD8_ENST00000609261.1_3'UTR			Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	280					cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity			endometrium(2)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	6		Hepatocellular(780;0.00335)				AGGAACAGCTCATCCCCAACT	0.587000													21	52					0	0	0.575678	0	0
SCAP	22937	broad.mit.edu	37	3	47470073	47470073	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:47470073C>T	ENST00000265565.5	-	4	752	c.340G>A	c.(340-342)Gta>Ata	p.V114I	SCAP_ENST00000441517.2_Intron|SCAP_ENST00000545718.1_Intron	NM_012235.2	NP_036367.2	Q12770	SCAP_HUMAN	SREBF chaperone	114					cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	26				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		GAACGAAATACATCTACTGCC	0.547000													61	88					0	0	0.870114	0	0
TMPRSS2	7113	broad.mit.edu	37	21	42848536	42848536	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:42848536G>T	ENST00000398585.3	-	8	866	c.806C>A	c.(805-807)tCt>tAt	p.S269Y	TMPRSS2_ENST00000458356.1_Missense_Mutation_p.S232Y|TMPRSS2_ENST00000332149.5_Missense_Mutation_p.S232Y	NM_001135099.1	NP_001128571.1	O15393	TMPS2_HUMAN	transmembrane protease, serine 2	232	Peptidase S1.				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ETV1(34)|TMPRSS2/ETV5_ENST00000306376(5)|TMPRSS2/ERG(3582)|TMPRSS2/ETV4(13)	central_nervous_system(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	4		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				TGCTTTTGAAGAACAGGCATC	0.428000			T	"""ERG, ETV1, ETV4, ETV5"""	prostate								10	57					3.07112e-06	3.19335e-06	0.387290	1	0
KIAA1033	23325	broad.mit.edu	37	12	105527601	105527601	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:105527601C>G	ENST00000332180.5	+	14	1340	c.1253C>G	c.(1252-1254)tCt>tGt	p.S418C		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	418					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						AAAATGGAATCTATTTTGTCT	0.343000													22	49					0	0	0.592651	0	0
MYOF	26509	broad.mit.edu	37	10	95072942	95072942	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:95072942G>A	ENST00000371501.4	-	51	5846	c.5724C>T	c.(5722-5724)caC>caT	p.H1908H	MYOF_ENST00000371502.4_Silent_p.H1898H|MYOF_ENST00000359263.4_Silent_p.H1908H|MYOF_ENST00000358334.5_Silent_p.H1895H			Q9NZM1	MYOF_HUMAN	myoferlin	1908					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GAATGATCGTGTGACGCAAGT	0.458000													30	53					0	0	0.729181	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36064860	36064860	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:36064860C>G	ENST00000258840.6	-	37	6202	c.5812G>C	c.(5812-5814)Gat>Cat	p.D1938H	RALGAPA1_ENST00000307138.6_Missense_Mutation_p.D1891H|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.D1891H|RALGAPA1_ENST00000382366.3_Missense_Mutation_p.D1904H	NM_001283044.1	NP_001269973.1	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	1891	Minimal domain that binds to TCF3/E12 (By similarity).|Rap-GAP.				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AAAGAATCATCAGAATCAGAA	0.338000													6	59					0	0	0.307466	0	0
TTN	7273	broad.mit.edu	37	2	179596192	179596192	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:179596192G>A	ENST00000589042.1	-	59	17525	c.17301C>T	c.(17299-17301)agC>agT	p.S5767S	TTN_ENST00000342992.6_Silent_p.S4523S|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.S5450S|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5450	Ig-like 38.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATTTCATCGCTGTCTTTTA	0.483000													3	36					0	0	0.115264	0	0
TOB1	10140	broad.mit.edu	37	17	48941123	48941123	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:48941123G>A	ENST00000499247.2	-	2	689	c.256C>T	c.(256-258)Ctg>Ttg	p.L86L	TOB1_ENST00000268957.3_Silent_p.L86L|TOB1_ENST00000509385.1_5'UTR	NM_001243885.1|NM_005749.3	NP_001230814.1|NP_005740.1	P50616	TOB1_HUMAN	transducer of ERBB2, 1	86					negative regulation of cell proliferation		SH3/SH2 adaptor activity			breast(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TCCTGTGGCAGATTGCCACGA	0.433000													33	90					0	0	0.788014	0	0
FOXO1	2308	broad.mit.edu	37	13	41133687	41133687	+	Silent	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:41133687T>C	ENST00000379561.5	-	2	2325	c.1941A>G	c.(1939-1941)acA>acG	p.T647T		NM_002015.3	NP_002006.2	Q12778	FOXO1_HUMAN	forkhead box O1	647					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX7/FOXO1(197)|PAX3/FOXO1(749)	central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	20		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		TATGTGTCGTTGTCTTGACAC	0.428000													40	56					0	0	0.870114	0	0
TTN	7273	broad.mit.edu	37	2	179501130	179501130	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:179501130A>G	ENST00000589042.1	-	225	41548	c.41324T>C	c.(41323-41325)gTa>gCa	p.V13775A	TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V11207A|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V4835A|TTN_ENST00000342175.6_Missense_Mutation_p.V4902A|TTN_ENST00000591111.1_Missense_Mutation_p.V12134A|TTN_ENST00000460472.2_Missense_Mutation_p.V4710A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12134	Ig-like 94.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTACCTTCTACAACAAGTTT	0.343000													7	3					0	0	0.278610	0	0
ZBTB26	57684	broad.mit.edu	37	9	125681289	125681289	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:125681289G>A	ENST00000373656.3	-	2	998	c.925C>T	c.(925-927)Cag>Tag	p.Q309*	ZBTB26_ENST00000373654.1_Nonsense_Mutation_p.Q309*	NM_020924.2	NP_065975.1	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)	11						TTGCCTTTCTGAGTGAAAGTC	0.443000													24	35					0	0	0.639603	0	0
BPIFB4	149954	broad.mit.edu	37	20	31671341	31671341	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:31671341G>A	ENST00000375483.3	+	3	338	c.338G>A	c.(337-339)gGa>gAa	p.G113E		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	113						cytoplasm|extracellular region	lipid binding										GAGTCCGAGGGAAGCATCAGG	0.552000													4	73					0	0	0.150653	0	0
DUS2	54920	broad.mit.edu	37	16	68071989	68071989	+	Silent	SNP	G	G	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:68071989G>T	ENST00000565263.1	+	3	557	c.63G>T	c.(61-63)cgG>cgT	p.R21R	DUS2_ENST00000432752.1_Silent_p.R21R|DUS2_ENST00000358896.6_Silent_p.R21R	NM_017803.3	NP_060273.1			dihydrouridine synthase 2	21																	CAATGGTTCGGGTAGGGACTC	0.473000													20	36					4.26978e-12	4.64783e-12	0.654019	1	0
FBN2	2201	broad.mit.edu	37	5	127638767	127638767	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:127638767C>T	ENST00000508053.1	-	52	6789	c.5815G>A	c.(5815-5817)Gag>Aag	p.E1939K	FBN2_ENST00000262464.4_Missense_Mutation_p.E1939K			P35556	FBN2_HUMAN	fibrillin 2	1939	EGF-like 32; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGATGCCGCTCGCACTCATCA	0.348000													31	6					0	0	0.760397	0	0
ROPN1L	83853	broad.mit.edu	37	5	10450167	10450167	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:10450167G>C	ENST00000503804.1	+	4	880	c.359G>C	c.(358-360)tGt>tCt	p.C120S	ROPN1L_ENST00000274134.4_Missense_Mutation_p.C120S|ROPN1L_ENST00000510520.1_3'UTR			Q96C74	ROP1L_HUMAN	rhophilin associated tail protein 1-like	120					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)	14						CTGGATCCTTGTGAAAACAAA	0.408000													20	103					0	0	0.608945	0	0
MAEL	84944	broad.mit.edu	37	1	166974581	166974581	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:166974581delT	ENST00000367872.4	+	8	1036	c.792delT	c.(790-792)actfs	p.T264fs	MAEL_ENST00000367870.2_Frame_Shift_Del_p.T233fs|MAEL_ENST00000491055.1_3'UTR	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	264					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						CCTCTAAGACTTGGATTCGAA	0.398													22	22	---	---	---	---					
AFF3	3899	broad.mit.edu	37	2	100218011	100218013	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:100218011_100218013delGCT	ENST00000409236.2	-	12	1367_1369	c.1255_1257delAGC	c.(1255-1257)agcdel	p.S419del	AFF3_ENST00000317233.4_In_Frame_Del_p.S419del|AFF3_ENST00000409579.1_In_Frame_Del_p.S444del|AFF3_ENST00000356421.2_In_Frame_Del_p.S444del			P51826	AFF3_HUMAN	AF4/FMR2 family, member 3		Poly-Ser.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						tgctgctgccgctgctgctgctg	0.685													3	6	---	---	---	---					
CDKN1A	1026	broad.mit.edu	37	6	36652011	36652012	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:36652011_36652012insC	ENST00000405375.1	+	2	368_369	c.133_134insC	c.(133-135)gccfs	p.A45fs	CDKN1A_ENST00000244741.5_Frame_Shift_Ins_p.A45fs|CDKN1A_ENST00000448526.2_Frame_Shift_Ins_p.A79fs|CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000373711.2_Frame_Shift_Ins_p.A45fs	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	45					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						CATCCAGGAGGCCCGTGAGCGA	0.658													20	23	---	---	---	---					
AC073316.1	0	broad.mit.edu	37	7	3311196	3311198	+	RNA	DEL	TGG	TGG	-	rs77310567	by1000genomes	TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:3311196_3311198delTGG	ENST00000437354.1	-	0	224																											gtggtgatgatggtggtggtggt	0.448													3	6	---	---	---	---					
BHLHE22	27319	broad.mit.edu	37	8	65493618	65493620	+	In_Frame_Del	DEL	GGC	GGC	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:65493618_65493620delGGC	ENST00000321870.1	+	1	805_807	c.271_273delGGC	c.(271-273)ggcdel	p.G97del	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	97	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						cgcgggaagtggcggcggcggcg	0.783													2	4	---	---	---	---					
RIMS2	9699	broad.mit.edu	37	8	104933968	104933968	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:104933968delG	ENST00000507740.1	+	8	1812	c.1576delG	c.(1576-1578)ggafs	p.G526fs	RIMS2_ENST00000436393.2_Frame_Shift_Del_p.G496fs|RIMS2_ENST00000262231.10_Frame_Shift_Del_p.G573fs|RIMS2_ENST00000406091.3_Frame_Shift_Del_p.G718fs	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	796					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CATGAGTCCTGGAATGTTGAG	0.348										HNSCC(12;0.0054)			30	54	---	---	---	---					
MROH5	389690	broad.mit.edu	37	8	142444233	142444234	+	RNA	INS	-	-	GGC	rs142460453	by1000genomes	TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:142444233_142444234insGGC	ENST00000430863.1	-	0	3937					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CAGGTGTTGGGGGGGTGGGGGG	0.644													3	5	---	---	---	---					
CHGA	1113	broad.mit.edu	37	14	93398816	93398818	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:93398816_93398818delGAG	ENST00000216492.5	+	7	1190_1192	c.910_912delGAG	c.(910-912)gagdel	p.E308del	CHGA_ENST00000334654.4_In_Frame_Del_p.E157del	NM_001275.3	NP_001266.1	P10645	CMGA_HUMAN	chromogranin A (parathyroid secretory protein 1)	308					regulation of blood pressure	extracellular region|stored secretory granule				cervix(1)|large_intestine(1)|lung(3)|skin(3)	8		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		CCAGCAGAAAGAGGAGGAGGAGG	0.655													2	4	---	---	---	---					
UNC13C	440279	broad.mit.edu	37	15	54825189	54825189	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:54825189delC	ENST00000545554.1	+	25	5621	c.5621delC	c.(5620-5622)accfs	p.T1875fs	UNC13C_ENST00000260323.11_Frame_Shift_Del_p.T1875fs|UNC13C_ENST00000537900.1_Frame_Shift_Del_p.T1873fs			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1875					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AATGGAAACACCACATCTAAT	0.313													7	4	---	---	---	---					
