Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NDST1	3340	broad.mit.edu	37	5	149925000	149925000	+	Silent	SNP	C	C	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr5:149925000C>T	ENST00000261797.6	+	11	2599	c.2097C>T	c.(2095-2097)gtC>gtT	p.V699V	NDST1_ENST00000523767.1_Silent_p.V699V	NM_001543.4	NP_001534.1	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	699	Heparan sulfate N-sulfotransferase 1.				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	34		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGCCAAGGTCCTGACCATCC	0.612000													10	179					0	0	1	0	0
NOC2L	26155	broad.mit.edu	37	1	883899	883899	+	Missense_Mutation	SNP	T	T	G	rs72631890		TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr1:883899T>G	ENST00000327044.6	-	13	1577	c.1528A>C	c.(1528-1530)Aat>Cat	p.N510H		NM_015658.3	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog (S. cerevisiae)	510						nucleolus	protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	16	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		AGGTTGACATTGGACAGCTTC	0.632000													3	33					0	0	1	0	0
SRL	6345	broad.mit.edu	37	16	4242840	4242840	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr16:4242840G>A	ENST00000399609.3	-	6	748	c.736C>T	c.(736-738)Cgt>Tgt	p.R246C	SRL_ENST00000537996.1_Missense_Mutation_p.R204C	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	705	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						TGGGATTCACGCCCCTTCAAC	0.542000													3	29					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182317	140182317	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr5:140182317C>T	ENST00000522353.2	+	1	1535	c.1535C>T	c.(1534-1536)gCg>gTg	p.A512V	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.A512V|PCDHA2_ENST00000520672.2_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGTACACGCGGAGAGCGGC	0.706000													36	108					0	0	1	0	0
CBR1	873	broad.mit.edu	37	21	37445142	37445142	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr21:37445142G>T	ENST00000290349.6	+	3	971	c.796G>T	c.(796-798)Gga>Tga	p.G266*	AP000688.14_ENST00000535199.1_RNA|SETD4_ENST00000399201.1_Intron|CBR1_ENST00000530908.1_3'UTR	NM_001757.2	NP_001748.1	P16152	CBR1_HUMAN	carbonyl reductase 1	266					drug metabolic process|vitamin K metabolic process	cytoplasm	15-hydroxyprostaglandin dehydrogenase (NADP+) activity|carbonyl reductase (NADPH) activity|prostaglandin-E2 9-reductase activity|protein binding			endometrium(2)|kidney(3)	5					Acetohexamide(DB00414)|Lubiprostone(DB01046)	GGGTCCCCATGGACAATTTGT	0.552000													4	33					1.23904e-05	1.37299e-05	1	1	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													8	16					0	0	1	0	0
WNT5B	81029	broad.mit.edu	37	12	1748963	1748963	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr12:1748963C>T	ENST00000397196.2	+	4	674	c.442C>T	c.(442-444)Cgg>Tgg	p.R148W	WNT5B_ENST00000537031.1_Missense_Mutation_p.R148W|WNT5B_ENST00000542408.1_Intron|WNT5B_ENST00000310594.3_Missense_Mutation_p.R148W	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	148					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			CCGGACGGCGCGGCCCAAGGA	0.731000													7	11					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4043448	4043448	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr16:4043448G>T	ENST00000294016.3	-	4	2486	c.1948C>A	c.(1948-1950)Cct>Act	p.P650T	ADCY9_ENST00000571889.1_5'UTR	NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	650					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CCGTTTTGAGGTGCTCCTCCC	0.542000													7	48					5.4927e-09	6.62355e-09	1	1	0
CYP51A1	1595	broad.mit.edu	37	7	91747927	91747927	+	Silent	SNP	G	G	C			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr7:91747927G>C	ENST00000003100.8	-	8	1254	c.1089C>G	c.(1087-1089)ctC>ctG	p.L363L	LRRD1_ENST00000422722.1_5'UTR|CYP51A1_ENST00000450723.1_Silent_p.L258L	NM_000786.3	NP_000777.1	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A, polypeptide 1	357					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	10	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	TTAGATCCTTGAGCTAAAATG	0.323000													3	35					0	0	1	0	0
RND1	27289	broad.mit.edu	37	12	49259511	49259511	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr12:49259511A>T	ENST00000309739.5	-	1	170	c.40T>A	c.(40-42)Tgt>Agt	p.C14S		NM_014470.3	NP_055285.1	Q92730	RND1_HUMAN	Rho family GTPase 1	14					actin filament organization|axon guidance|negative regulation of cell adhesion|neuron remodeling|small GTPase mediated signal transduction	adherens junction|cytoskeleton|cytosol	GTP binding|GTPase activity|receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|ovary(2)|skin(1)|urinary_tract(1)	10						ACGAGCTTACATCTGGCCACG	0.617000													28	27					0	0	1	0	0
PI4KAP1	728233	broad.mit.edu	37	22	20386732	20386732	+	RNA	SNP	G	G	A	rs143107404	by1000genomes	TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr22:20386732G>A	ENST00000430523.3	-	0	1780					NR_003563.1																						GGGCAAGGACGAGTGGTCTGT	0.572000													5	11					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	71004166	71004166	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr6:71004166G>A	ENST00000357250.6	-	5	558	c.400C>T	c.(400-402)Cag>Tag	p.Q134*	COL9A1_ENST00000370496.3_Nonsense_Mutation_p.Q134*	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	134	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						GAGGAATCCTGAATCTGCCAA	0.428000													22	61					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884803	24884803	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr14:24884803G>A	ENST00000382554.3	+	9	4166	c.3848G>A	c.(3847-3849)cGc>cAc	p.R1283H		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1283					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GGGGAGAACCGCCTGCTCACC	0.612000													19	58					0	0	1	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240627	39240627	+	Missense_Mutation	SNP	T	T	C	rs139671425	by1000genomes	TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr17:39240627T>C	ENST00000391417.4	+	1	169	c.169T>C	c.(169-171)Tct>Cct	p.S57P		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.S57P(4)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						GTGCTGCCAGTCTGTGTGCTG	0.667000													4	40					0	0	1	0	0
AIMP2	7965	broad.mit.edu	37	7	6063231	6063231	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr7:6063231G>T	ENST00000223029.3	+	4	991	c.872G>T	c.(871-873)tGc>tTc	p.C291F	AIMP2_ENST00000395236.2_Missense_Mutation_p.C222F|AIMP2_ENST00000400479.2_Missense_Mutation_p.C213F|EIF2AK1_ENST00000199389.6_3'UTR	NM_006303.3	NP_006294.2	Q13155	AIMP2_HUMAN	aminoacyl tRNA synthetase complex-interacting multifunctional protein 2	291	GST C-terminal.				apoptosis|cell differentiation|multicellular organismal development|tRNA aminoacylation for protein translation	cytosol|nucleus	protein binding			large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						ATCGGAGGCTGCAGTGTGACA	0.542000													7	29					2.0095e-06	2.35398e-06	1	1	0
PGR	5241	broad.mit.edu	37	11	100922293	100922293	+	Missense_Mutation	SNP	C	C	T	rs149186732	byFrequency	TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr11:100922293C>T	ENST00000325455.5	-	5	3672	c.2219G>A	c.(2218-2220)cGa>cAa	p.R740Q	PGR_ENST00000534013.1_Missense_Mutation_p.R146Q|PGR_ENST00000263463.5_Missense_Mutation_p.R638Q	NM_000926.4|NM_001202474.1|NM_001271162.1	NP_000917.3|NP_001189403.1|NP_001258091.1	P06401	PRGR_HUMAN	progesterone receptor	740	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding	p.R740Q(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	ATGTAAGTTTCGAAAACCTAC	0.328000													13	11					0	0	1	0	0
TRAFD1	10906	broad.mit.edu	37	12	112572632	112572632	+	Silent	SNP	T	T	C			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr12:112572632T>C	ENST00000257604.5	+	3	755	c.138T>C	c.(136-138)ttT>ttC	p.F46F	TRAFD1_ENST00000412615.2_Silent_p.F46F	NM_001143906.1	NP_001137378.1	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	46					negative regulation of innate immune response	intracellular	protein binding|zinc ion binding			kidney(5)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	17						AGGAACCATTTCCCAAATCTG	0.408000													8	68					0	0	1	0	0
DKK1	22943	broad.mit.edu	37	10	54074410	54074410	+	Silent	SNP	T	T	C			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr10:54074410T>C	ENST00000373970.3	+	1	355	c.216T>C	c.(214-216)aaT>aaC	p.N72N		NM_012242.2	NP_036374.1	O94907	DKK1_HUMAN	dickkopf WNT signaling pathway inhibitor 1	72					negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			kidney(2)|large_intestine(4)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	16						CGGGCGGGAATAAGTACCAGA	0.627000											OREG0020191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	33					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219252542	219252542	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr2:219252542A>G	ENST00000233202.6	+	8	999	c.659A>G	c.(658-660)gAg>gGg	p.E220G	SLC11A1_ENST00000539932.1_Missense_Mutation_p.E102G	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	220					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCGCGTCCTGAGCAGGGAGCG	0.682000													9	7					0	0	1	0	0
TOR1A	1861	broad.mit.edu	37	9	132581155	132581155	+	Silent	SNP	C	C	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr9:132581155C>T	ENST00000351698.4	-	3	537	c.489G>A	c.(487-489)gcG>gcA	p.A163A		NM_000113.2	NP_000104.1	O14656	TOR1A_HUMAN	torsin family 1, member A (torsin A)	163					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20		Ovarian(14;0.00556)				AGATGGACCTCGCACAGGCAC	0.468000													9	19					0	0	1	0	0
CBR1	873	broad.mit.edu	37	21	37445143	37445143	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr21:37445143G>T	ENST00000290349.6	+	3	972	c.797G>T	c.(796-798)gGa>gTa	p.G266V	AP000688.14_ENST00000535199.1_RNA|SETD4_ENST00000399201.1_Intron|CBR1_ENST00000530908.1_3'UTR	NM_001757.2	NP_001748.1	P16152	CBR1_HUMAN	carbonyl reductase 1	266					drug metabolic process|vitamin K metabolic process	cytoplasm	15-hydroxyprostaglandin dehydrogenase (NADP+) activity|carbonyl reductase (NADPH) activity|prostaglandin-E2 9-reductase activity|protein binding			endometrium(2)|kidney(3)	5					Acetohexamide(DB00414)|Lubiprostone(DB01046)	GGTCCCCATGGACAATTTGTT	0.557000													4	33					1.23904e-05	1.37299e-05	1	1	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	RNA	SNP	G	G	A			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr15:102515299G>A	ENST00000557932.1	+	0	1145																		p.G374S(10)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGGGGGCATCGGCAAGGCCAA	0.652000													4	12					0	0	1	0	0
RGS16	6004	broad.mit.edu	37	1	182569575	182569575	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr1:182569575G>A	ENST00000367558.5	-	5	609	c.461C>T	c.(460-462)gCg>gTg	p.A154V		NM_002928.3	NP_002919.3	O15492	RGS16_HUMAN	regulator of G-protein signaling 16	154	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			NS(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(1)	11						CCCCTGAGCCGCATCAAAGCA	0.602000													4	74					0	0	1	0	0
GABBR1	2550	broad.mit.edu	37	6	29581118	29581118	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr6:29581118G>A	ENST00000377034.4	-	12	1803	c.1468C>T	c.(1468-1470)Cgt>Tgt	p.R490C	GABBR1_ENST00000377012.4_Missense_Mutation_p.R373C|GABBR1_ENST00000376977.3_Missense_Mutation_p.R490C|GABBR1_ENST00000377016.4_Missense_Mutation_p.R428C|GABBR1_ENST00000355973.3_Missense_Mutation_p.R373C	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	490					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	ACACCAGAACGGCCGCCTCCT	0.572000													18	61					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131337056	131337056	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr9:131337056C>T	ENST00000358161.5	+	4	579	c.466C>T	c.(466-468)Cga>Tga	p.R156*	SPTAN1_ENST00000372739.3_Nonsense_Mutation_p.R156*|SPTAN1_ENST00000372731.4_Nonsense_Mutation_p.R156*			Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	156					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GCAGTACTTACGAGAATGTGA	0.478000													4	37					0	0	1	0	0
ZNF564	163050	broad.mit.edu	37	19	12637790	12637790	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr19:12637790G>T	ENST00000339282.7	-	4	1328	c.1132C>A	c.(1132-1134)Cca>Aca	p.P378T	ZNF709_ENST00000428311.1_Intron|CTD-2192J16.20_ENST00000593682.1_3'UTR	NM_144976.3	NP_659413.1			zinc finger protein 564											endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						CGGACACTTGGGAGAGAAATG	0.433000													37	60					3.62531e-18	4.50417e-18	1	1	0
MMP19	4327	broad.mit.edu	37	12	56233305	56233305	+	Silent	SNP	A	A	G			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr12:56233305A>G	ENST00000322569.4	-	5	832	c.741T>C	c.(739-741)gaT>gaC	p.D247D	MMP19_ENST00000548629.1_Silent_p.D224D|MMP19_ENST00000409200.3_Intron	NM_002429.4	NP_002420.1	Q99542	MMP19_HUMAN	matrix metallopeptidase 19	247					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						TCCCTGCCACATCATCTGGGT	0.612000													11	21					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144931089	144931089	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr1:144931089C>T	ENST00000529945.1	-	1	1059	c.620G>A	c.(619-621)tGc>tAc	p.C207Y	PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.C207Y|PDE4DIP_ENST00000369354.3_Intron|PDE4DIP_ENST00000369351.3_Intron|PDE4DIP_ENST00000369349.3_Intron|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000479408.2_Intron|PDE4DIP_ENST00000369356.4_Intron|PDE4DIP_ENST00000313382.9_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTCTTCAGTGCAAATGCTGGT	0.542000			T	PDGFRB	MPD								13	61					0	0	1	0	0
C4orf27	54969	broad.mit.edu	37	4	170658885	170658885	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr4:170658885G>C	ENST00000393381.2	-	6	737	c.662C>G	c.(661-663)aCc>aGc	p.T221S		NM_017867.2	NP_060337.2	Q9NWY4	CD027_HUMAN	chromosome 4 open reading frame 27	221						nucleus				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)	12		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.018)|LUSC - Lung squamous cell carcinoma(193;0.116)		ACCATGAAAGGTCTTTGTCAC	0.353000													3	33					0	0	1	0	0
AIMP2	7965	broad.mit.edu	37	7	6063232	6063232	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr7:6063232C>G	ENST00000223029.3	+	4	992	c.873C>G	c.(871-873)tgC>tgG	p.C291W	AIMP2_ENST00000395236.2_Missense_Mutation_p.C222W|AIMP2_ENST00000400479.2_Missense_Mutation_p.C213W|EIF2AK1_ENST00000199389.6_3'UTR	NM_006303.3	NP_006294.2	Q13155	AIMP2_HUMAN	aminoacyl tRNA synthetase complex-interacting multifunctional protein 2	291	GST C-terminal.				apoptosis|cell differentiation|multicellular organismal development|tRNA aminoacylation for protein translation	cytosol|nucleus	protein binding			large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						TCGGAGGCTGCAGTGTGACAG	0.542000													7	30					0	0	1	0	0
TRMT61B	55006	broad.mit.edu	37	2	29092834	29092834	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr2:29092834C>A	ENST00000306108.5	-	1	333	c.310G>T	c.(310-312)Gac>Tac	p.D104Y		NM_017910.3	NP_060380.3	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B (S. cerevisiae)	104							tRNA (adenine-N1-)-methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)	13						CCGCTCGAGTCCTCGAGCTCT	0.627000													5	34					0.0293803	0.0293803	1	1	0
WDR81	124997	broad.mit.edu	37	17	1637151	1637151	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr17:1637151C>T	ENST00000409644.1	+	7	4820	c.4820C>T	c.(4819-4821)cCg>cTg	p.P1607L	RP11-961A15.1_ENST00000576540.1_RNA|WDR81_ENST00000545662.1_Missense_Mutation_p.P238L|WDR81_ENST00000419248.1_Missense_Mutation_p.P380L|WDR81_ENST00000309182.5_Missense_Mutation_p.P556L|WDR81_ENST00000446363.1_Missense_Mutation_p.P246L|WDR81_ENST00000437219.2_Missense_Mutation_p.P404L	NM_001163809.1	NP_001157281.1	B3KXU1	B3KXU1_HUMAN	WD repeat domain 81	380										cervix(1)|endometrium(1)|kidney(3)|lung(6)|ovary(2)|prostate(2)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CAGGAGCTGCCGCGGAGCGTG	0.687000													15	56					0	0	1	0	0
RP11-435B5.5	0	broad.mit.edu	37	1	143391935	143391936	+	RNA	INS	-	-	TG			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr1:143391935_143391936insTG	ENST00000428624.1	+	0	2065				RP11-435B5.4_ENST00000423249.1_lincRNA																							ATATATATATATAAAGAGATTG	0.252													3	3	---	---	---	---					
SPTBN1	6711	broad.mit.edu	37	2	54839354	54839357	+	Frame_Shift_Del	DEL	CCTT	CCTT	-			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr2:54839354_54839357delCCTT	ENST00000333896.5	+	3	703_706	c.318_321delCCTT	c.(316-321)gcccttfs	p.AL106fs	SPTBN1_ENST00000356805.4_Frame_Shift_Del_p.AL119fs	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	119	Actin-binding.|CH 1.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			TGGACAAGGCCCTTCAGTTCCTGA	0.534													12	56	---	---	---	---					
ACTB	60	broad.mit.edu	37	7	5568826	5568827	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr7:5568826_5568827insG	ENST00000331789.5	-	3	519_520	c.328_329insC	c.(328-330)ctgfs	p.L110fs		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	110					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		CTTGGGGTTCAGGGGGGCCTCG	0.649													15	28	---	---	---	---					
TRIM50	135892	broad.mit.edu	37	7	72727177	72727177	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr7:72727177delG	ENST00000333149.2	-	7	1404	c.1204delC	c.(1204-1206)cggfs	p.R402fs	TRIM50_ENST00000453152.1_Frame_Shift_Del_p.R402fs	NM_178125.2	NP_835226.2	Q86XT4	TRI50_HUMAN	tripartite motif containing 50	402	B30.2/SPRY.					cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)	20						AGGGGTACCCGGGGGCAGGCA	0.677													2	4	---	---	---	---					
CTBP2	1488	broad.mit.edu	37	10	126682434	126682437	+	Frame_Shift_Del	DEL	CTGA	CTGA	-	rs112585658		TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr10:126682434_126682437delCTGA	ENST00000309035.6	-	6	2648_2651	c.2518_2521delTCAG	c.(2518-2523)tcagagfs	p.SE840fs	CTBP2_ENST00000337195.5_Frame_Shift_Del_p.SE300fs|CTBP2_ENST00000334808.6_Frame_Shift_Del_p.SE368fs|CTBP2_ENST00000531469.1_Frame_Shift_Del_p.SE300fs|CTBP2_ENST00000411419.2_Frame_Shift_Del_p.SE300fs|CTBP2_ENST00000494626.2_Frame_Shift_Del_p.SE300fs	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	300					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CTGAAGGGCTCTGACTCATGCACG	0.637													17	76	---	---	---	---					
PDS5B	23047	broad.mit.edu	37	13	33344887	33344888	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr13:33344887_33344888insA	ENST00000315596.10	+	33	4346_4347	c.4160_4161insA	c.(4159-4164)ccaaaafs	p.PK1387fs		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	1387					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding	p.N1390fs*4(1)		NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		CCATCACAACCAAAAAAAAATG	0.337													4	6	---	---	---	---					
ZFP36L1	677	broad.mit.edu	37	14	69256981	69256982	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr14:69256981_69256982insG	ENST00000439696.2	-	2	586_587	c.285_286insC	c.(283-288)ggcgagfs	p.E96fs	ZFP36L1_ENST00000555997.1_3'UTR|ZFP36L1_ENST00000336440.3_Frame_Shift_Ins_p.E96fs	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	96					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AGCAGCCGCTCGCCCCCTTCCG	0.678											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	56	---	---	---	---					
MYH11	4629	broad.mit.edu	37	16	15813473	15813473	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr16:15813473delC	ENST00000452625.2	-	36	5159	c.5072delG	c.(5071-5073)agcfs	p.S1691fs	NDE1_ENST00000342673.5_Intron|NDE1_ENST00000396354.1_Intron|MYH11_ENST00000300036.5_Frame_Shift_Del_p.S1684fs|MYH11_ENST00000576790.2_Frame_Shift_Del_p.S1684fs|MYH11_ENST00000396324.3_Frame_Shift_Del_p.S1691fs|NDE1_ENST00000396355.1_Intron	NM_001040113.1	NP_001035202.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1684					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						TGCTTCCAAGCTCTTGGCTTT	0.537			T	CBFB	AML								10	83	---	---	---	---					
PLCD3	113026	broad.mit.edu	37	17	43209664	43209664	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr17:43209664delG	ENST00000322765.5	-	1	227	c.114delC	c.(112-114)cccfs	p.P38fs	PLCD3_ENST00000540511.1_5'UTR	NM_133373.3	NP_588614.1	Q8N3E9	PLCD3_HUMAN	phospholipase C, delta 3	38					intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	17					Phosphatidylserine(DB00144)	CGCCATCGGAGGGAGTCGGCG	0.766													2	4	---	---	---	---					
MN1	4330	broad.mit.edu	37	22	28194934	28194936	+	In_Frame_Del	DEL	TGC	TGC	-	rs45480998		TCGA-CF-A47S-01A-11D-A23U-08	TCGA-CF-A47S-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc66f1a9-0bea-4137-bda3-df6241ad446a	e18f50ad-f783-421b-ac1d-5e982bcc35da	g.chr22:28194934_28194936delTGC	ENST00000302326.4	-	1	2550_2552	c.1596_1598delGCA	c.(1594-1599)cagcaa>caa	p.532_533QQ>Q		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	532	Poly-Gln.						binding	p.Q532Q(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						ctgctgctgttgctgctgctgct	0.650			T	ETV6	"""AML, meningioma"""								3	5	---	---	---	---					
