Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TBC1D15	64786	broad.mit.edu	37	12	72312286	72312286	+	Silent	SNP	C	C	T	rs141790587	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:72312286C>T	ENST00000550746.1	+	15	1672	c.1608C>T	c.(1606-1608)ttC>ttT	p.F536F	TBC1D15_ENST00000393309.3_Silent_p.F290F|TBC1D15_ENST00000319106.8_Silent_p.F527F|TBC1D15_ENST00000485960.2_Silent_p.F519F	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	536	Rab-GAP TBC.						protein binding|Rab GTPase activator activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TAATCAGATTCAAAAGGGAAT	0.294000													27	92					0	0	0.183431	0	0
HPSE2	60495	broad.mit.edu	37	10	100249921	100249921	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:100249921C>G	ENST00000370552.3	-	10	1412	c.1353G>C	c.(1351-1353)ctG>ctC	p.L451L	HPSE2_ENST00000370549.1_Silent_p.L393L|HPSE2_ENST00000370546.1_Silent_p.L451L|HPSE2_ENST00000404542.1_Silent_p.L339L	NM_021828.4	NP_068600.4	Q8WWQ2	HPSE2_HUMAN	heparanase 2	451					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	40				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TGGGGCCGATCAGGCGCTTGT	0.557000													42	67					0	0	0.323286	0	0
SAMD7	344658	broad.mit.edu	37	3	169654187	169654187	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:169654187C>T	ENST00000428432.2	+	8	1491	c.1102C>T	c.(1102-1104)Cga>Tga	p.R368*	SAMD7_ENST00000335556.3_Nonsense_Mutation_p.R368*	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	368	SAM.									NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AGAGCATCTTCGAGGCACTAT	0.353000													15	91					0	0	0.204396	0	0
CAPG	822	broad.mit.edu	37	2	85625197	85625197	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85625197C>T	ENST00000263867.4	-	8	1087	c.838G>A	c.(838-840)Gat>Aat	p.D280N	CAPG_ENST00000483659.1_5'UTR|CAPG_ENST00000409921.1_Missense_Mutation_p.D265N|CAPG_ENST00000409670.1_Missense_Mutation_p.D280N|CAPG_ENST00000409724.1_Missense_Mutation_p.D280N	NM_001256140.1|NM_001747.3	NP_001243069.1|NP_001738.2	P40121	CAPG_HUMAN	capping protein (actin filament), gelsolin-like	280					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)	11						AAGCAGTCATCAGATATCAGC	0.547000													19	133					0	0	0.323286	0	0
COL2A1	1280	broad.mit.edu	37	12	48375126	48375126	+	Splice_Site	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:48375126C>T	ENST00000380518.3	-	37	2627	c.2463G>A	c.(2461-2463)ccG>ccA	p.P821P	COL2A1_ENST00000493991.1_5'UTR|COL2A1_ENST00000337299.6_Splice_Site_p.P752P	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	821	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	AGACACTCACCGGAGCGCCAC	0.662000													8	16					0	0	0.387290	0	0
MALAT1	378938	broad.mit.edu	37	11	65273165	65273165	+	RNA	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65273165G>T	ENST00000534336.1	+	0	7933					NR_002819.2																						TTGGTGGGTTGAACTATGTTA	0.428000													28	68					4.74835e-14	5.2073e-14	0.396831	1	0
MYB	4602	broad.mit.edu	37	6	135511379	135511379	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:135511379G>C	ENST00000341911.5	+	5	620	c.421G>C	c.(421-423)Gaa>Caa	p.E141Q	MYB_ENST00000534044.1_Missense_Mutation_p.E141Q|MYB_ENST00000533624.1_Missense_Mutation_p.E141Q|MYB_ENST00000525369.1_Missense_Mutation_p.E141Q|MYB_ENST00000420123.2_Missense_Mutation_p.E117Q|MYB_ENST00000527615.1_Missense_Mutation_p.E141Q|MYB_ENST00000442647.2_Missense_Mutation_p.E141Q|MYB_ENST00000534121.1_Missense_Mutation_p.E141Q|MYB_ENST00000316528.8_Missense_Mutation_p.E141Q|MYB_ENST00000531845.1_3'UTR|MYB_ENST00000528774.1_Missense_Mutation_p.E141Q|MYB_ENST00000367814.4_Missense_Mutation_p.E141Q	NM_001130173.1|NM_001161656.1|NM_001161658.1	NP_001123645.1|NP_001155128.1|NP_001155130.1	P10242	MYB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog	141	HTH myb-type 2.|Interaction with HIPK2 and NLK (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		CTTGAATCCAGAAGTTAAGAA	0.453000			T	NFIB	adenoid cystic carcinoma								9	53					0	0	0.335167	0	0
CDK3	1018	broad.mit.edu	37	17	73998125	73998125	+	Missense_Mutation	SNP	G	G	C	rs140567861		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:73998125G>C	ENST00000425876.2	+	3	305	c.217G>C	c.(217-219)Gag>Cag	p.E73Q	CDK3_ENST00000448471.1_Missense_Mutation_p.E73Q|TEN1-CDK3_ENST00000567351.1_RNA			Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	73	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity	p.E73K(1)		central_nervous_system(1)	1						GGTGCACAACGAGAGGAAGCT	0.572000													14	68					0	0	0.175082	0	0
PPRC1	23082	broad.mit.edu	37	10	103906708	103906708	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103906708G>C	ENST00000278070.2	+	9	3998	c.3959G>C	c.(3958-3960)cGa>cCa	p.R1320P	PPRC1_ENST00000413464.2_Intron|PPRC1_ENST00000370012.1_Missense_Mutation_p.R287P|PPRC1_ENST00000489648.1_Intron	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GTGGGCTCCCGATGGAATGTC	0.607000													11	42					0	0	0.387290	0	0
MAGEB1	4112	broad.mit.edu	37	X	30269617	30269617	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:30269617C>G	ENST00000378981.3	+	4	1328	c.1007C>G	c.(1006-1008)tCt>tGt	p.S336C	MAGEB1_ENST00000397548.2_Missense_Mutation_p.S336C|MAGEB1_ENST00000397550.1_Missense_Mutation_p.S336C	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	336										NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						AGAGCGCGTTCTAGAGCCCCA	0.507000													24	14					0	0	0.338820	0	0
CLASP1	23332	broad.mit.edu	37	2	122182786	122182786	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:122182786G>A	ENST00000263710.4	-	22	2530	c.2141C>T	c.(2140-2142)tCa>tTa	p.S714L	CLASP1_ENST00000545861.1_Missense_Mutation_p.S490L|CLASP1_ENST00000541377.1_Missense_Mutation_p.S721L|CLASP1_ENST00000455322.2_Missense_Mutation_p.S714L|CLASP1_ENST00000541859.1_Missense_Mutation_p.S483L|CLASP1_ENST00000409078.3_Missense_Mutation_p.S714L|CLASP1_ENST00000397587.3_Missense_Mutation_p.S722L	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	714	Interaction with microtubules, MAPRE1 and MAPRE3.|Ser-rich.				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					TCGCTTTTCTGAAGACGGTGT	0.512000													31	68					0	0	0.183431	0	0
CASP5	838	broad.mit.edu	37	11	104871143	104871143	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:104871143G>A	ENST00000393141.2	-	6	867	c.836C>T	c.(835-837)tCt>tTt	p.S279F	CASP5_ENST00000260315.3_Missense_Mutation_p.S266F|CASP5_ENST00000444749.2_Missense_Mutation_p.S208F|CASP5_ENST00000418434.1_Missense_Mutation_p.S124F|CASP5_ENST00000526056.1_Missense_Mutation_p.S279F|CASP5_ENST00000393139.2_3'UTR|CASP5_ENST00000531367.1_Missense_Mutation_p.S124F	NM_001136112.1|NM_004347.3	NP_001129584.1|NP_004338.3	P51878	CASP5_HUMAN	caspase 5, apoptosis-related cysteine peptidase	266					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|ovary(3)|skin(1)|urinary_tract(1)	35		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		GATGCCATGAGACATGAGTAC	0.463000													23	70					0	0	0.324025	0	0
UBA3	9039	broad.mit.edu	37	3	69124658	69124658	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:69124658G>C	ENST00000361055.4	-	4	241	c.187C>G	c.(187-189)Ctc>Gtc	p.L63V	UBA3_ENST00000415609.2_Intron|UBA3_ENST00000349511.4_Missense_Mutation_p.L49V|UBA3_ENST00000540295.1_Intron	NM_003968.3	NP_003959.3	Q8TBC4	UBA3_HUMAN	ubiquitin-like modifier activating enzyme 3	63	Interaction with UBE2M N-terminus.				protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		AAGAACTGGAGAGACTGTAAA	0.343000													16	39					0	0	0.219247	0	0
KLHDC8B	200942	broad.mit.edu	37	3	49212384	49212384	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49212384T>G	ENST00000332780.2	+	4	960	c.751T>G	c.(751-753)Ttt>Gtt	p.F251V	KLHDC8B_ENST00000476495.2_3'UTR	NM_173546.2	NP_775817.1	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	251						cytoplasm				endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)|stomach(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGTGGAGATGTTTGACCTGGA	0.587000													12	82					0	0	0.132662	0	0
DLEC1	9940	broad.mit.edu	37	3	38136538	38136538	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:38136538C>A	ENST00000308059.6	+	13	2109	c.2088C>A	c.(2086-2088)ttC>ttA	p.F696L	DLEC1_ENST00000346219.3_Missense_Mutation_p.F696L|DLEC1_ENST00000452631.2_Missense_Mutation_p.F696L			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	696					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		ACCACGAGTTCATCCTGAGCT	0.517000													15	61					7.92952e-12	8.53726e-12	0.294199	1	0
MLLT4-AS1	653483	broad.mit.edu	37	6	168226338	168226338	+	RNA	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:168226338C>T	ENST00000359760.5	-	0	1051					NR_027906.1																						GAGCGCGGTTCAGAAAACATG	0.552000													18	37					0	0	0.249174	0	0
FAM195A	84331	broad.mit.edu	37	16	697532	697532	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:697532T>A	ENST00000307650.4	+	3	477	c.298T>A	c.(298-300)Ttt>Att	p.F100I		NM_138418.2	NP_612427.2	Q9BUT9	F195A_HUMAN	family with sequence similarity 195, member A	100										haematopoietic_and_lymphoid_tissue(1)|kidney(1)	2						GAATGTCCGCTTTGTGTCCGA	0.637000													7	23					0	0	0.335167	0	0
KIAA2018	205717	broad.mit.edu	37	3	113376375	113376375	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:113376375G>A	ENST00000316407.4	-	7	4564	c.4154C>T	c.(4153-4155)tCa>tTa	p.S1385L	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Missense_Mutation_p.S1385L	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1385					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						AGGCACAACTGAGTTTGAAGA	0.448000													13	53					0	0	0.119110	0	0
SLC14A2	8170	broad.mit.edu	37	18	43216988	43216988	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:43216988C>T	ENST00000255226.6	+	6	1500	c.684C>T	c.(682-684)ttC>ttT	p.F228F	SLC14A2_ENST00000586448.1_Silent_p.F228F	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	228						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ATTCCATCTTCAGCAAGTGGG	0.512000													107	236					0	0	0.323286	0	0
PRUNE2	158471	broad.mit.edu	37	9	79318656	79318656	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:79318656C>T	ENST00000428286.1	-	9	7996	c.6796G>A	c.(6796-6798)Gaa>Aaa	p.E2266K	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E2625K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2625					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GCAGGGCTTTCAAAAGATGAT	0.493000													3	9					0	0	0.115264	0	0
CHIT1	1118	broad.mit.edu	37	1	203192738	203192738	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:203192738G>C	ENST00000367229.1	-	5	399	c.365C>G	c.(364-366)tCg>tGg	p.S122W	CHIT1_ENST00000255427.3_Missense_Mutation_p.S103W|CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000535569.1_Missense_Mutation_p.S113W	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	122					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						CCTGATGGCCGAGTTGACAAA	0.577000													22	180					0	0	0.324025	0	0
KRT80	144501	broad.mit.edu	37	12	52574306	52574306	+	Silent	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:52574306G>T	ENST00000313234.5	-	4	754	c.657C>A	c.(655-657)atC>atA	p.I219I	KRT80_ENST00000394815.2_Silent_p.I219I	NM_001081492.1	NP_001074961.1	Q6KB66	K2C80_HUMAN	keratin 80	219	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		CCTGCTCATAGATGGTTTTCA	0.552000													36	158					4.67007e-22	5.36058e-22	0.268233	1	0
MUC16	94025	broad.mit.edu	37	19	9062870	9062870	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:9062870C>G	ENST00000397910.4	-	3	24779	c.24576G>C	c.(24574-24576)atG>atC	p.M8192I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8194	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGATTCTGTCATTATGCTGG	0.483000													13	31					0	0	0.093190	0	0
CAPG	822	broad.mit.edu	37	2	85622055	85622055	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85622055C>A	ENST00000263867.4	-	10	1257	c.1008G>T	c.(1006-1008)gaG>gaT	p.E336D	CAPG_ENST00000409921.1_Missense_Mutation_p.E321D|CAPG_ENST00000409670.1_Missense_Mutation_p.E336D|CAPG_ENST00000409724.1_Missense_Mutation_p.E336D	NM_001256140.1|NM_001747.3	NP_001243069.1|NP_001738.2	P40121	CAPG_HUMAN	capping protein (actin filament), gelsolin-like	336					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)	11						AGATGGGACTCTCATGGCCCT	0.597000													14	46					0.000132079	0.000136235	0.204396	1	0
BPIFA2	140683	broad.mit.edu	37	20	31767433	31767433	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:31767433C>A	ENST00000253362.2	+	7	815	c.669C>A	c.(667-669)ttC>ttA	p.F223L	BPIFA2_ENST00000354932.5_Missense_Mutation_p.F223L			Q96DR5	SPLC2_HUMAN	BPI fold containing family A, member 2	223						extracellular region	lipid binding										TCCGCATCTTCATCCACTCCC	0.527000													60	147					5.02048e-33	5.86551e-33	0.323286	1	0
CAPG	822	broad.mit.edu	37	2	85622017	85622017	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85622017C>T	ENST00000263867.4	-	10	1295	c.1046G>A	c.(1045-1047)tGa>tAa	p.*349*	CAPG_ENST00000409921.1_Silent_p.*334*|CAPG_ENST00000409670.1_Silent_p.*349*|CAPG_ENST00000409724.1_Silent_p.*349*	NM_001256140.1|NM_001747.3	NP_001243069.1|NP_001738.2	P40121	CAPG_HUMAN	capping protein (actin filament), gelsolin-like	0					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)	11						CGCCCACCCTCATTTCCAGTC	0.592000													17	48					0	0	0.234183	0	0
APBB3	10307	broad.mit.edu	37	5	139941016	139941016	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:139941016C>A	ENST00000357560.4	-	9	1209	c.766G>T	c.(766-768)Gag>Tag	p.E256*	APBB3_ENST00000508496.2_Nonsense_Mutation_p.E33*|APBB3_ENST00000354402.5_Nonsense_Mutation_p.E263*|APBB3_ENST00000511201.2_Nonsense_Mutation_p.E254*|APBB3_ENST00000356738.2_Nonsense_Mutation_p.E261*|APBB3_ENST00000412920.3_Nonsense_Mutation_p.E254*|APBB3_ENST00000358580.5_Nonsense_Mutation_p.E256*	NM_006051.3|NM_133173.2	NP_006042.3|NP_573419.2	O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	256	PID 1.					actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACTGACCTCTACTCGCTCT	0.547000													23	141					8.24728e-16	9.16365e-16	0.309145	1	0
ZZEF1	23140	broad.mit.edu	37	17	3984727	3984727	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:3984727C>T	ENST00000381638.2	-	18	2896	c.2772G>A	c.(2770-2772)atG>atA	p.M924I	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	924							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CACTGATGTTCATCTTGGCCA	0.498000													44	50					0	0	0.323286	0	0
MSTN	2660	broad.mit.edu	37	2	190926953	190926953	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190926953C>G	ENST00000260950.4	-	1	502	c.370G>C	c.(370-372)Gag>Cag	p.E124Q	C2orf88_ENST00000478197.1_Intron	NM_005259.2	NP_005250.1	O14793	GDF8_HUMAN	myostatin	124					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)	12			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TACTTACACTCTGTAGGCATG	0.403000													44	218					0	0	0.323286	0	0
DMXL2	23312	broad.mit.edu	37	15	51758463	51758463	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:51758463C>T	ENST00000251076.5	-	30	7722	c.7435G>A	c.(7435-7437)Gaa>Aaa	p.E2479K	RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000449909.3_Missense_Mutation_p.E1843K|DMXL2_ENST00000543779.2_Missense_Mutation_p.E2480K	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2479						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		TGAATGCTTTCATCAGAATCA	0.284000													37	68					0	0	0.323286	0	0
MYH3	4621	broad.mit.edu	37	17	10539067	10539067	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:10539067C>T	ENST00000583535.1	-	29	4047	c.3960G>A	c.(3958-3960)ctG>ctA	p.L1320L	MYH3_ENST00000226209.7_Silent_p.L1320L	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1320					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TCTCTTCCTCCAGCTGCCTCT	0.423000													51	78					0	0	0.323286	0	0
SEC14L3	266629	broad.mit.edu	37	22	30860840	30860840	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:30860840C>T	ENST00000403066.1	-	9	737	c.454G>A	c.(454-456)Gag>Aag	p.E152K	SEC14L3_ENST00000539629.1_Missense_Mutation_p.E152K|SEC14L3_ENST00000401751.1_Missense_Mutation_p.E152K|SEC14L3_ENST00000402286.1_Missense_Mutation_p.E134K|SEC14L3_ENST00000540910.1_Missense_Mutation_p.E134K|SEC14L3_ENST00000215812.4_Missense_Mutation_p.E211K|SEC14L3_ENST00000415957.2_Missense_Mutation_p.E152K			Q9UDX4	S14L3_HUMAN	SEC14-like 3 (S. cerevisiae)	211	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	19					Vitamin E(DB00163)	CGAGTGTCCTCACTCAGGAAT	0.448000													60	121					0	0	0.323286	0	0
MLYCD	23417	broad.mit.edu	37	16	83948929	83948929	+	Silent	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:83948929G>T	ENST00000262430.4	+	5	1336	c.1317G>T	c.(1315-1317)gtG>gtT	p.V439V	RP11-505K9.4_ENST00000566309.1_Intron|RP11-505K9.4_ENST00000561562.1_Intron	NM_012213.2	NP_036345.2	O95822	DCMC_HUMAN	malonyl-CoA decarboxylase	439					acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity			NS(1)|biliary_tract(1)|breast(1)|kidney(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						TGGCGGATGTGAGCCTCAGAG	0.637000													121	71					1.799e-87	2.11436e-87	0.323286	1	0
NSDHL	50814	broad.mit.edu	37	X	152014895	152014895	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:152014895G>A	ENST00000370274.3	+	2	221	c.27G>A	c.(25-27)atG>atA	p.M9I	NSDHL_ENST00000440023.1_Missense_Mutation_p.M9I	NM_015922.2	NP_057006.1	Q15738	NSDHL_HUMAN	NAD(P) dependent steroid dehydrogenase-like	9					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(5)	15	Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	GCGAGCCAATGAGAGACCAAG	0.408000													31	33					0	0	0.279185	0	0
ABCA6	23460	broad.mit.edu	37	17	67132242	67132242	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:67132242C>G	ENST00000284425.2	-	4	625	c.451G>C	c.(451-453)Gat>Cat	p.D151H	ABCA6_ENST00000590645.1_Missense_Mutation_p.D151H	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	151					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CCTGAGAAATCTTCTTTCCAA	0.323000													5	31					0	0	0.217242	0	0
ZZZ3	26009	broad.mit.edu	37	1	78034131	78034131	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:78034131G>C	ENST00000370801.3	-	13	2827	c.2352C>G	c.(2350-2352)atC>atG	p.I784M	ZZZ3_ENST00000476275.1_5'UTR|ZZZ3_ENST00000370798.1_Missense_Mutation_p.I290M	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	784					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						TCCTATACATGATAGGAATAC	0.269000													12	11					0	0	0.387290	0	0
PTK7	5754	broad.mit.edu	37	6	43096807	43096807	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:43096807C>G	ENST00000230419.4	+	2	393	c.172C>G	c.(172-174)Ccg>Gcg	p.P58A	PTK7_ENST00000345201.2_Missense_Mutation_p.P58A|PTK7_ENST00000349241.2_Missense_Mutation_p.P58A|PTK7_ENST00000352931.2_Missense_Mutation_p.P58A|PTK7_ENST00000476760.1_Missense_Mutation_p.P58A|PTK7_ENST00000481273.1_Missense_Mutation_p.P66A|PTK7_ENST00000471863.1_Missense_Mutation_p.P58A	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	58	Ig-like C2-type 1.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GGTTGAGGCTCCGGGCCCGGT	0.642000													11	16					0	0	0.146539	0	0
AKAP13	11214	broad.mit.edu	37	15	86064775	86064775	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:86064775C>T	ENST00000394518.2	+	3	245	c.150C>T	c.(148-150)gtC>gtT	p.V50V	AKAP13_ENST00000560302.1_Silent_p.V50V|AKAP13_ENST00000361243.2_Silent_p.V50V	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	50					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						CTCGGAAGGTCAGTTCTGATA	0.418000													17	103					0	0	0.204396	0	0
RNF10	9921	broad.mit.edu	37	12	121001720	121001720	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:121001720G>C	ENST00000325954.4	+	10	2100	c.1639G>C	c.(1639-1641)Gag>Cag	p.E547Q	RNF10_ENST00000413266.2_Missense_Mutation_p.E552Q	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	547					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AACTGTGGTGGAGATTGCTGG	0.552000													19	153					0	0	0.309145	0	0
SMAD3	4088	broad.mit.edu	37	15	67457371	67457371	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:67457371G>A	ENST00000327367.4	+	2	655	c.345G>A	c.(343-345)atG>atA	p.M115I	SMAD3_ENST00000540846.2_Missense_Mutation_p.M10I|SMAD3_ENST00000439724.3_Missense_Mutation_p.M71I|SMAD3_ENST00000559092.1_Silent_p.*97*	NM_005902.3	NP_005893.1	P84022	SMAD3_HUMAN	SMAD family member 3	115	MH1.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(11)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CCTTCAATATGAAGAAGGACG	0.602000													15	99					0	0	0.189662	0	0
ZNF777	27153	broad.mit.edu	37	7	149129883	149129883	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:149129883C>G	ENST00000247930.4	-	6	1803	c.1480G>C	c.(1480-1482)Gag>Cag	p.E494Q		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	494					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGGGACATCTCCCCGGGCAGC	0.662000													7	27					0	0	0.307466	0	0
THAP11	57215	broad.mit.edu	37	16	67876898	67876898	+	Silent	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67876898G>T	ENST00000303596.1	+	1	686	c.441G>T	c.(439-441)ccG>ccT	p.P147P	CENPT_ENST00000562787.1_Intron	NM_020457.2	NP_065190.2	Q96EK4	THA11_HUMAN	THAP domain containing 11	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|urinary_tract(1)	8		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		AGCTGCAGCCGAACCTGGTAT	0.642000													35	182					2.56175e-15	2.8357e-15	0.323286	1	0
GABARAPL3	23766	broad.mit.edu	37	15	90892117	90892117	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:90892117G>T	ENST00000412799.2	-	1	552	c.313C>A	c.(313-315)Ctg>Atg	p.L105M																								GCCACATACAGAAAATCATCT	0.493000													14	32					7.81268e-19	8.83042e-19	0.160694	1	0
BCAN	63827	broad.mit.edu	37	1	156617355	156617355	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156617355G>A	ENST00000329117.5	+	4	858	c.522G>A	c.(520-522)ggG>ggA	p.G174G	RP11-284F21.7_ENST00000448869.1_RNA|BCAN_ENST00000361588.5_Silent_p.G174G	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican		Link 1.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCTTTTCTGGGGCCCAGGAGG	0.642000													13	35					0	0	0.146539	0	0
CAPG	822	broad.mit.edu	37	2	85625194	85625194	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85625194C>T	ENST00000263867.4	-	8	1090	c.841G>A	c.(841-843)Gac>Aac	p.D281N	CAPG_ENST00000483659.1_5'UTR|CAPG_ENST00000409921.1_Missense_Mutation_p.D266N|CAPG_ENST00000409670.1_Missense_Mutation_p.D281N|CAPG_ENST00000409724.1_Missense_Mutation_p.D281N	NM_001256140.1|NM_001747.3	NP_001243069.1|NP_001738.2	P40121	CAPG_HUMAN	capping protein (actin filament), gelsolin-like	281					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)	11						ACAAAGCAGTCATCAGATATC	0.547000													23	129					0	0	0.323286	0	0
TMEM89	440955	broad.mit.edu	37	3	48658340	48658340	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48658340G>T	ENST00000330862.3	-	2	513	c.415C>A	c.(415-417)Cac>Aac	p.H139N		NM_001008269.1	NP_001008270.1	A2RUT3	TMM89_HUMAN	transmembrane protein 89	139						integral to membrane				breast(1)|lung(1)|stomach(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		TGACGTAGGTGGCCTTCGATG	0.612000													35	86					4.65686e-17	5.19386e-17	0.193644	1	0
ZNF479	90827	broad.mit.edu	37	7	57188109	57188109	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:57188109G>A	ENST00000331162.4	-	5	1283	c.1013C>T	c.(1012-1014)tCa>tTa	p.S338L		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			AGTAAGGTTTGAGGACCAGCT	0.453000													10	42					0	0	0.146539	0	0
RXRG	6258	broad.mit.edu	37	1	165370572	165370572	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:165370572G>C	ENST00000359842.5	-	10	1622	c.1320C>G	c.(1318-1320)ttC>ttG	p.F440L		NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	440	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CGATGAGCTTGAAGAAGAAGA	0.597000													49	98					0	0	0.323286	0	0
ADAT1	23536	broad.mit.edu	37	16	75642774	75642774	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:75642774C>G	ENST00000307921.3	-	8	1301	c.1156G>C	c.(1156-1158)Gat>Cat	p.D386H		NM_012091.3	NP_036223.2	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	386	A to I editase.				tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)	19						CCTGGGCTATCAGCCCTTTTT	0.512000													23	57					0	0	0.324025	0	0
TNRC6B	23112	broad.mit.edu	37	22	40661039	40661039	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:40661039C>G	ENST00000454349.2	+	5	1016	c.805C>G	c.(805-807)Caa>Gaa	p.Q269E	TNRC6B_ENST00000402203.1_Intron|TNRC6B_ENST00000301923.9_Intron|TNRC6B_ENST00000335727.9_Missense_Mutation_p.Q269E	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	269					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						TAAATCTGTTCAATCTTCCAA	0.453000													8	64					0	0	0.278610	0	0
ASPRV1	151516	broad.mit.edu	37	2	70188511	70188511	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:70188511C>G	ENST00000320256.4	-	1	886	c.310G>C	c.(310-312)Gaa>Caa	p.E104Q		NM_152792.2	NP_690005.2	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1	104					protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			endometrium(3)|large_intestine(4)|lung(6)|ovary(1)	14						TCAAAAGGTTCCGGGACGAAG	0.582000													22	66					0	0	0.294199	0	0
GREB1	9687	broad.mit.edu	37	2	11728988	11728988	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:11728988G>A	ENST00000381486.2	+	10	1576	c.1276G>A	c.(1276-1278)Gcc>Acc	p.A426T	GREB1_ENST00000234142.5_Missense_Mutation_p.A426T|GREB1_ENST00000381483.2_Missense_Mutation_p.A426T	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	426						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GCAGTACGGCGCCTCTGCCAT	0.597000													57	111					0	0	0.323286	0	0
GH1	2688	broad.mit.edu	37	17	61994708	61994708	+	Silent	SNP	G	G	A	rs148474991		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:61994708G>A	ENST00000323322.5	-	5	657	c.615C>T	c.(613-615)atC>atT	p.I205I	GH1_ENST00000351388.4_Silent_p.I165I|GH1_ENST00000342364.4_Silent_p.I110I|GH1_ENST00000458650.2_Silent_p.I190I|CSHL1_ENST00000392824.4_Intron	NM_000515.3	NP_000506.2	P01241	SOMA_HUMAN	growth hormone 1	205			I -> M (in short stature; idiopathic autosomal).		glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding	p.I205M(1)		breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	19						GGCACTGCACGATGCGCAGGA	0.592000													25	61					0	0	0.368089	0	0
LRRC57	255252	broad.mit.edu	37	15	42839461	42839461	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:42839461G>C	ENST00000323443.2	-	3	857	c.490C>G	c.(490-492)Cag>Gag	p.Q164E	LRRC57_ENST00000397130.3_Missense_Mutation_p.Q164E|LRRC57_ENST00000563454.1_Missense_Mutation_p.Q164E			Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	164										breast(1)|kidney(1)|lung(5)|prostate(1)	8		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		CTCTAGACCTGATTCTGGTTG	0.443000													9	59					0	0	0.387290	0	0
PITPNM3	83394	broad.mit.edu	37	17	6374547	6374547	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:6374547C>A	ENST00000262483.8	-	12	1645	c.1558G>T	c.(1558-1560)Gag>Tag	p.E520*	PITPNM3_ENST00000421306.3_Nonsense_Mutation_p.E484*|PITPNM3_ENST00000576664.1_5'UTR	NM_031220.3	NP_112497.2	Q9BZ71	PITM3_HUMAN	PITPNM family member 3		DDHD.				phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(3)|skin(2)	36				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		GAGCTCCCCTCGCTCATCCTC	0.687000													7	18					0.00448238	0.00459133	0.307466	1	0
CENPF	1063	broad.mit.edu	37	1	214815002	214815002	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:214815002G>A	ENST00000366955.3	+	12	3489	c.3321G>A	c.(3319-3321)caG>caA	p.Q1107Q		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	1107					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGACAGTGCAGCAAGCTCTGA	0.373000													3	115					0	0	0.184627	0	0
GMFB	2764	broad.mit.edu	37	14	54950455	54950455	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:54950455C>A	ENST00000554908.1	-	2	131	c.34G>T	c.(34-36)Gaa>Taa	p.E12*	GMFB_ENST00000553566.1_5'UTR|GMFB_ENST00000358056.3_Nonsense_Mutation_p.E12*			P60983	GMFB_HUMAN	glia maturation factor, beta	12	ADF-H.				nervous system development|protein phosphorylation	intracellular	actin binding|enzyme activator activity|growth factor activity|protein kinase inhibitor activity|signal transducer activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)	8						ACTAAATCTTCGGCAACATCA	0.338000													11	29					3.32936e-07	3.49523e-07	0.175082	1	0
FAM199X	139231	broad.mit.edu	37	X	103411483	103411483	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:103411483C>T	ENST00000493442.1	+	1	183	c.17C>T	c.(16-18)tCg>tTg	p.S6L		NM_207318.3	NP_997201.1	Q6PEV8	F199X_HUMAN	family with sequence similarity 199, X-linked	6										breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)	11						GACGAGGCCTCGGCCATCACT	0.701000													5	1					0	0	0.217242	0	0
RBPMS2	348093	broad.mit.edu	37	15	65040670	65040670	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:65040670G>A	ENST00000300069.4	-	6	782	c.515C>T	c.(514-516)gCt>gTt	p.A172V	RBPMS2_ENST00000560606.1_Missense_Mutation_p.A61V	NM_194272.1	NP_919248.1	Q6ZRY4	RBPS2_HUMAN	RNA binding protein with multiple splicing 2	172							nucleic acid binding|nucleotide binding			breast(1)|large_intestine(3)|lung(3)|prostate(1)	8						GGTGAACGCAGCATGGGAGAT	0.622000													24	51					0	0	0.353513	0	0
TRIB3	57761	broad.mit.edu	37	20	376874	376874	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:376874C>T	ENST00000217233.3	+	4	1170	c.617C>T	c.(616-618)tCc>tTc	p.S206F	TRIB3_ENST00000422053.2_Missense_Mutation_p.S233F	NM_021158.3	NP_066981.2	Q96RU7	TRIB3_HUMAN	tribbles pseudokinase 3	206	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|skin(1)	21		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		CTGGAGGACTCCTGCGTGCTG	0.607000													12	57					0	0	0.119110	0	0
ATP2B4	493	broad.mit.edu	37	1	203680026	203680026	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:203680026G>A	ENST00000357681.5	+	12	2944	c.1821G>A	c.(1819-1821)cgG>cgA	p.R607R	ATP2B4_ENST00000341360.2_Silent_p.R607R|ATP2B4_ENST00000367219.3_Silent_p.R595R|ATP2B4_ENST00000391954.2_Silent_p.R607R|ATP2B4_ENST00000367218.3_Silent_p.R607R	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	607					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TCCTGGACCGGAAAGGGGAAG	0.502000													15	24					0	0	0.132662	0	0
DENND6A	201627	broad.mit.edu	37	3	57649368	57649368	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:57649368G>C	ENST00000311128.5	-	5	578	c.508C>G	c.(508-510)Cag>Gag	p.Q170E		NM_152678.2	NP_689891.1			DENN/MADD domain containing 6A																		ATTACCTTCTGAAAGTAGCCT	0.289000													25	68					0	0	0.183431	0	0
FOXI2	399823	broad.mit.edu	37	10	129537070	129537070	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:129537070G>A	ENST00000388920.4	+	2	837	c.798G>A	c.(796-798)ctG>ctA	p.L266L		NM_207426.2	NP_997309.2	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	266					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|lung(3)	4		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				CCGGGGGCCTGGCGGGCGACT	0.701000													4	3					0	0	0.217242	0	0
TOP2A	7153	broad.mit.edu	37	17	38569453	38569453	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38569453G>C	ENST00000423485.1	-	6	728	c.570C>G	c.(568-570)ttC>ttG	p.F190L		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	190					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding	p.F190L(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TTGCCTGTTTGAACATTTTCT	0.328000													2	5					0	0	0.115264	0	0
ULK1	8408	broad.mit.edu	37	12	132404537	132404537	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:132404537G>C	ENST00000321867.4	+	26	3168	c.2817G>C	c.(2815-2817)ctG>ctC	p.L939L	ULK1_ENST00000540647.1_Silent_p.L184L	NM_003565.2	NP_003556	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	939					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TGCGCAGGCTGAATGAGCTGT	0.647000													9	48					0	0	0.387290	0	0
DACH1	1602	broad.mit.edu	37	13	72053449	72053449	+	Splice_Site	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:72053449C>T	ENST00000305425.4	-	8	2151		c.e8-1		DACH1_ENST00000354591.4_Splice_Site|DACH1_ENST00000313174.7_Splice_Site|DACH1_ENST00000359684.2_Splice_Site	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding	p.?(1)		NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TCAACAGCCCCTGTACAAAGA	0.358000													26	109					0	0	0.193644	0	0
OR5M8	219484	broad.mit.edu	37	11	56258214	56258214	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:56258214G>A	ENST00000327216.2	-	1	657	c.633C>T	c.(631-633)ttC>ttT	p.F211F		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					TACATATGATGAAGAGAGAAA	0.433000													8	69					0	0	0.307466	0	0
CC2D1B	200014	broad.mit.edu	37	1	52824767	52824767	+	Missense_Mutation	SNP	C	C	G	rs144724390	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:52824767C>G	ENST00000371586.2	-	11	1327	c.1189G>C	c.(1189-1191)Gag>Cag	p.E397Q	CC2D1B_ENST00000284376.3_Missense_Mutation_p.E397Q|CC2D1B_ENST00000460261.1_5'UTR|CC2D1B_ENST00000438831.1_5'UTR	NM_032449.2	NP_115825.1	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	397										breast(1)|large_intestine(6)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	27						ATGCCCGCCTCGCGGTACTTG	0.632000													8	37					0	0	0.335167	0	0
ZZEF1	23140	broad.mit.edu	37	17	4045961	4045961	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:4045961G>A	ENST00000381638.2	-	1	353	c.229C>T	c.(229-231)Cgc>Tgc	p.R77C	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	77							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						AACGCGCCGCGATGCCTCGAC	0.721000													8	11					0	0	0.361761	0	0
GANAB	23193	broad.mit.edu	37	11	62398117	62398117	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62398117G>A	ENST00000346178.4	-	12	1423	c.1408C>T	c.(1408-1410)Cag>Tag	p.Q470*	GANAB_ENST00000540933.1_Nonsense_Mutation_p.Q351*|GANAB_ENST00000356638.3_Nonsense_Mutation_p.Q448*|GANAB_ENST00000534779.1_Nonsense_Mutation_p.Q356*	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	448					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						GTGCGGGGCTGAGGGAAGCGA	0.547000													11	58					0	0	0.105934	0	0
GSTM5	2949	broad.mit.edu	37	1	110257876	110257876	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:110257876C>T	ENST00000369813.1	+	5	1363	c.458C>T	c.(457-459)tCc>tTc	p.S153F	GSTM5_ENST00000492718.1_3'UTR|GSTM5_ENST00000369812.5_Intron|GSTM5_ENST00000256593.3_Intron			P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	0	GST C-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			NS(1)|central_nervous_system(6)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	21		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	ATGCCCCCATCCTCCTTTCTC	0.473000													28	36					0	0	0.338820	0	0
CCT6P3	643180	broad.mit.edu	37	7	64530046	64530046	+	RNA	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:64530046C>G	ENST00000426828.1	+	0	866					NR_033416.1																						CAGGCTGACTCTTGCTTGTGG	0.398000													4	34					0	0	0.248553	0	0
SLC6A15	55117	broad.mit.edu	37	12	85264443	85264443	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:85264443G>A	ENST00000266682.5	-	9	1850	c.1309C>T	c.(1309-1311)Cag>Tag	p.Q437*	SLC6A15_ENST00000552192.1_Nonsense_Mutation_p.Q330*|SLC6A15_ENST00000309283.7_Nonsense_Mutation_p.Q145*	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	437					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						CCGGTCCCCTGAACAGCCTGC	0.398000													18	49					0	0	0.189662	0	0
PPRC1	23082	broad.mit.edu	37	10	103908426	103908426	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103908426G>C	ENST00000278070.2	+	11	4631	c.4592G>C	c.(4591-4593)aGa>aCa	p.R1531T	PPRC1_ENST00000413464.2_Missense_Mutation_p.R1267T|PPRC1_ENST00000370012.1_Missense_Mutation_p.R498T|PPRC1_ENST00000489648.1_3'UTR	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1531	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CAAAGGCAAAGAGTGCTACAA	0.493000													41	104					0	0	0.323286	0	0
MALAT1	378938	broad.mit.edu	37	11	65272679	65272679	+	RNA	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65272679G>T	ENST00000534336.1	+	0	7447					NR_002819.2																						TAAAGGCACCGAAGGCTTAAA	0.502000													9	16					0.000442599	0.000455731	0.335167	1	0
FAN1	22909	broad.mit.edu	37	15	31197525	31197525	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:31197525C>G	ENST00000362065.4	+	2	950	c.659C>G	c.(658-660)tCt>tGt	p.S220C	FAN1_ENST00000565466.1_Missense_Mutation_p.S220C|FAN1_ENST00000561594.1_Missense_Mutation_p.S220C|FAN1_ENST00000561607.1_Missense_Mutation_p.S220C	NM_014967.4	NP_055782.3	Q9Y2M0	FAN1_HUMAN	FANCD2/FANCI-associated nuclease 1	220					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding			autonomic_ganglia(2)|breast(2)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(6)|lung(8)|skin(1)	29						AAATGTGATTCTCTAAAGGAA	0.393000								Direct reversal of damage					20	38					0	0	0.219247	0	0
MUC17	140453	broad.mit.edu	37	7	100679868	100679868	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:100679868C>G	ENST00000306151.4	+	3	5235	c.5171C>G	c.(5170-5172)tCt>tGt	p.S1724C		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1724	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTGACCACTTCTACTGAAGCC	0.478000													79	512					0	0	0.323286	0	0
INPP5E	56623	broad.mit.edu	37	9	139326391	139326391	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:139326391G>A	ENST00000371712.3	-	7	1836	c.1434C>T	c.(1432-1434)ttC>ttT	p.F478F		NM_019892.4	NP_063945.2	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase, 72 kDa	478						cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			NS(1)|endometrium(1)|lung(4)|skin(3)	9		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		GGCGGAAGTTGAAGTCTCCAA	0.667000													22	23					0	0	0.368089	0	0
PRICKLE3	4007	broad.mit.edu	37	X	49040246	49040246	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:49040246C>G	ENST00000376317.3	-	3	347	c.253G>C	c.(253-255)Gac>Cac	p.D85H	PRICKLE3_ENST00000536904.1_Missense_Mutation_p.D17H|PRICKLE3_ENST00000376310.3_Missense_Mutation_p.D85H|PRICKLE3_ENST00000540849.1_Missense_Mutation_p.D17H|PRICKLE3_ENST00000538114.1_Missense_Mutation_p.D85H	NM_006150.3	NP_006141.2	O43900	PRIC3_HUMAN	prickle homolog 3 (Drosophila)	85	PET.						protein binding|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|skin(2)	22						CAGCCTGAGTCGTCGTCGGAG	0.642000													30	15					0	0	0.235728	0	0
GAD1	2571	broad.mit.edu	37	2	171702544	171702544	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:171702544G>C	ENST00000358196.3	+	10	1523	c.973G>C	c.(973-975)Gag>Cag	p.E325Q		NM_000817.2	NP_000808.2	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 (brain, 67kDa)	325					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(15)|ovary(1)|urinary_tract(2)	35					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AGCTGATTTTGAGGCAAAAAT	0.363000													22	105					0	0	0.324025	0	0
EML3	256364	broad.mit.edu	37	11	62378418	62378418	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62378418G>A	ENST00000394773.2	-	4	806	c.499C>T	c.(499-501)Cgg>Tgg	p.R167W	EML3_ENST00000529309.1_Missense_Mutation_p.R167W|EML3_ENST00000531557.1_5'UTR|EML3_ENST00000494176.2_Missense_Mutation_p.R139W|EML3_ENST00000278845.4_Missense_Mutation_p.R168W	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	167						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						AGCTTCTGCCGAGGCCGCTCT	0.612000													12	74					0	0	0.132662	0	0
ABCC9	10060	broad.mit.edu	37	12	21958120	21958120	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:21958120C>T	ENST00000261201.4	-	38	4637	c.4638G>A	c.(4636-4638)atG>atA	p.M1546I	ABCC9_ENST00000261200.4_Intron|ABCC9_ENST00000345162.2_Missense_Mutation_p.M1510I	NM_005691.2	NP_005682.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1546	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.M1546I(1)		NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACTTGTTGGTCATCACCAAAG	0.438000													16	62					0	0	0.219247	0	0
MPP6	51678	broad.mit.edu	37	7	24705264	24705264	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:24705264G>C	ENST00000222644.5	+	7	1091	c.841G>C	c.(841-843)Gag>Cag	p.E281Q	MPP6_ENST00000396475.2_Missense_Mutation_p.E281Q|MPP6_ENST00000409761.1_Missense_Mutation_p.E169Q			Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)		SH3.				protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						GTTCCTGGAAGAGAAGAGAAA	0.423000													12	64					0	0	0.132662	0	0
TERF2IP	54386	broad.mit.edu	37	16	75681873	75681873	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:75681873C>G	ENST00000300086.4	+	1	190	c.93C>G	c.(91-93)ttC>ttG	p.F31L		NM_018975.3	NP_061848.2	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting protein	31					negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)	5						CCATGTCCTTCTACGTGCGGC	0.682000													12	52					0	0	0.105934	0	0
AGRP	181	broad.mit.edu	37	16	67517183	67517183	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67517183G>C	ENST00000290953.2	-	2	418	c.119C>G	c.(118-120)cCa>cGa	p.P40R	RP11-297D21.4_ENST00000602596.1_RNA	NM_001138.1	NP_001129.1	O00253	AGRP_HUMAN	agouti related protein homolog (mouse)	40					hormone-mediated signaling pathway|neuropeptide signaling pathway|regulation of feeding behavior	extracellular space|Golgi lumen	neuropeptide hormone activity			endometrium(1)	1		Acute lymphoblastic leukemia(13;0.00263)|all_hematologic(13;0.0274)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0717)|Epithelial(162;0.16)		TGGGAGCTCTGGGAGCAGGGC	0.637000													3	4					0	0	0.115264	0	0
MALAT1	378938	broad.mit.edu	37	11	65272325	65272325	+	RNA	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65272325G>T	ENST00000534336.1	+	0	7093					NR_002819.2																						CGAAGGGCCAGAGAAGCCAGA	0.413000													7	48					0.0381472	0.0386053	0.278610	1	0
PLEKHA8	84725	broad.mit.edu	37	7	30102287	30102287	+	Splice_Site	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:30102287G>C	ENST00000449726.1	+	12	1579		c.e12-1		PLEKHA8_ENST00000258679.7_Splice_Site|PLEKHA8_ENST00000396257.2_Splice_Site|PLEKHA8_ENST00000396259.1_Splice_Site	NM_001197027.1	NP_001183956.1	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8						protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						TTTTGTTTTAGAGGTCTCAAA	0.328000													11	39					0	0	0.093190	0	0
DOPEY2	9980	broad.mit.edu	37	21	37603182	37603182	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:37603182C>G	ENST00000399151.3	+	14	2185	c.2100C>G	c.(2098-2100)ttC>ttG	p.F700L		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	700					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CAGACTTGTTCACAGCACGAG	0.542000													8	81					0	0	0.307466	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43522898	43522898	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:43522898C>G	ENST00000430334.3	-	9	2908	c.2775G>C	c.(2773-2775)ctG>ctC	p.L925L	PLEKHM1_ENST00000421073.2_Silent_p.L836L|PLEKHM1_ENST00000580404.1_5'UTR	NM_014798.2	NP_055613.1	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 1	925					intracellular signal transduction	cytoplasm	metal ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26	Renal(3;0.0405)					CCAGGAGCTTCAGCTGCTCCC	0.607000													17	57					0	0	0.175082	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46387865	46387865	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:46387865C>T	ENST00000302165.3	-	1	1511	c.1168G>A	c.(1168-1170)Gag>Aag	p.E390K		NM_015649.1	NP_056464.1	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein 1	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(1)|kidney(1)|lung(2)	4		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CCAGCCGCCTCGCCCTCCGGC	0.751000													9	20					0	0	0.335167	0	0
LHX4	89884	broad.mit.edu	37	1	180241097	180241097	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:180241097C>G	ENST00000263726.2	+	5	978	c.734C>G	c.(733-735)tCt>tGt	p.S245C	RP5-1180C10.2_ENST00000415414.1_RNA	NM_033343.3	NP_203129.1	Q969G2	LHX4_HUMAN	LIM homeobox 4	245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)	16						AAGGAGAGCTCTGCAGAGGAC	0.617000													5	44					0	0	0.248553	0	0
INPP5A	3632	broad.mit.edu	37	10	134459392	134459392	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:134459392G>A	ENST00000368594.3	+	3	415	c.138G>A	c.(136-138)ccG>ccA	p.P46P	INPP5A_ENST00000368593.3_Silent_p.P46P	NM_005539.3	NP_005530.3	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase, 40kDa	46					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			cervix(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		CACACAAGCCGCACTTCATGG	0.612000													20	34					0	0	0.353513	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48604701	48604701	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:48604701C>T	ENST00000323776.5	+	15	2514	c.2352C>T	c.(2350-2352)ctC>ctT	p.L784L	MYCBPAP_ENST00000436259.2_Silent_p.L747L	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	747					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TGATGAGGCTCAACAAAGCAG	0.592000													20	119					0	0	0.219247	0	0
RFC4	5984	broad.mit.edu	37	3	186509528	186509528	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:186509528T>C	ENST00000392481.2	-	8	1068	c.787A>G	c.(787-789)Aca>Gca	p.T263A	RFC4_ENST00000433496.1_Missense_Mutation_p.T263A|RFC4_ENST00000296273.2_Missense_Mutation_p.T263A	NM_181573.2	NP_853551.1	P35249	RFC4_HUMAN	replication factor C (activator 1) 4, 37kDa	263					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		GCAATGTCTGTAATCACTTTC	0.373000													3	126					0	0	0.115264	0	0
INF2	64423	broad.mit.edu	37	14	105174218	105174218	+	Silent	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:105174218C>A	ENST00000392634.4	+	8	1726	c.1614C>A	c.(1612-1614)atC>atA	p.I538I	INF2_ENST00000330634.7_Silent_p.I538I	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	538					actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		AGGAGGTCATCGTGGCCCAGG	0.677000													5	23					3.59834e-05	3.72459e-05	0.217242	1	0
DPT	1805	broad.mit.edu	37	1	168665804	168665804	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:168665804C>T	ENST00000367817.3	-	4	678	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K		NM_001937.4	NP_001928.2	Q07507	DERM_HUMAN	dermatopontin	197					cell adhesion	extracellular space|proteinaceous extracellular matrix				kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)	12	all_hematologic(923;0.208)					TTTGCAAATTCACAGTCGTAT	0.473000													9	61					0	0	0.361761	0	0
SNHG12	85028	broad.mit.edu	37	1	28907553	28907553	+	RNA	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:28907553C>A	ENST00000488745.1	-	0	1013				SNHG12_ENST00000531126.1_RNA|SNHG12_ENST00000475441.1_RNA|SNHG12_ENST00000483436.1_RNA|SNHG12_ENST00000384342.1_RNA																							GCTGCAGCTTCGATAAGGGCC	0.532000													16	74					4.96729e-08	5.25215e-08	0.204396	1	0
MUC6	4588	broad.mit.edu	37	11	1028937	1028937	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:1028937C>T	ENST00000421673.2	-	12	1455	c.1405G>A	c.(1405-1407)Gag>Aag	p.E469K		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	469	VWFD 2.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTGACCACCTCGTCCTGAGAG	0.627000													33	49					0	0	0.312237	0	0
FOXC2	2303	broad.mit.edu	37	16	86601504	86601504	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:86601504C>T	ENST00000320354.4	+	1	648	c.563C>T	c.(562-564)cCg>cTg	p.P188L		NM_005251.2	NP_005242.1	Q99958	FOXC2_HUMAN	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	188					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	15						GAGCCGCCCCCGGCGGCGTCC	0.701000									Late-onset Hereditary Lymphedema				7	18					0	0	0.361761	0	0
NARS2	79731	broad.mit.edu	37	11	78239958	78239958	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:78239958C>T	ENST00000281038.5	-	6	994	c.619G>A	c.(619-621)Gag>Aag	p.E207K	NARS2_ENST00000528850.1_5'UTR	NM_001243251.1|NM_024678.5	NP_001230180.1|NP_078954.4	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial (putative)	207					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)	27	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	AAATTCTCCTCAGGTACCTTA	0.353000													35	75					0	0	0.246493	0	0
GRIN1	2902	broad.mit.edu	37	9	140051368	140051368	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140051368G>A	ENST00000371561.3	+	6	1944	c.847G>A	c.(847-849)Gac>Aac	p.D283N	GRIN1_ENST00000350902.5_Missense_Mutation_p.D283N|GRIN1_ENST00000371546.4_Missense_Mutation_p.D304N|GRIN1_ENST00000371555.4_Missense_Mutation_p.D304N|GRIN1_ENST00000371553.3_Missense_Mutation_p.D304N|GRIN1_ENST00000315048.3_Missense_Mutation_p.D283N|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000371550.4_Missense_Mutation_p.D283N|GRIN1_ENST00000371559.4_Missense_Mutation_p.D283N|GRIN1_ENST00000371560.3_Missense_Mutation_p.D304N	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	283					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCACATCAGCGACGCCGTGGG	0.672000													7	3					0	0	0.278610	0	0
NR1D2	9975	broad.mit.edu	37	3	24003672	24003672	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:24003672C>T	ENST00000312521.4	+	5	1041	c.722C>T	c.(721-723)tCt>tTt	p.S241F	NR1D2_ENST00000492552.1_3'UTR	NM_001145425.1|NM_005126.4	NP_001138897.1|NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	241					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			NS(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	22						ATCAAAAGCTCTTCTCCTCCA	0.448000													14	32					0	0	0.146539	0	0
CORO7-PAM16	100529144	broad.mit.edu	37	16	4390379	4390379	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:4390379C>T	ENST00000572467.1	-	31	3156	c.3088G>A	c.(3088-3090)Gag>Aag	p.E1030K	PAM16_ENST00000573553.1_Missense_Mutation_p.E127K|PAM16_ENST00000576217.1_Missense_Mutation_p.E107K|PAM16_ENST00000575848.1_Missense_Mutation_p.E119K|PAM16_ENST00000318059.3_Missense_Mutation_p.E107K|PAM16_ENST00000577031.1_Intron|PAM16_ENST00000571941.1_Missense_Mutation_p.E127K	NM_001201479.1	NP_001188408.1																					TTGAGTTCCTCATCCAGGCGC	0.622000													23	41					0	0	0.309145	0	0
MALAT1	378938	broad.mit.edu	37	11	65273802	65273802	+	RNA	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65273802G>C	ENST00000534336.1	+	0	8570					NR_002819.2																						AGCTTGACTTGATTGTATATT	0.398000													8	19					0	0	0.307466	0	0
TTC8	123016	broad.mit.edu	37	14	89336504	89336504	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:89336504C>G	ENST00000338104.6	+	11	1111	c.1059C>G	c.(1057-1059)ttC>ttG	p.F353L	TTC8_ENST00000358622.5_Missense_Mutation_p.F139L|TTC8_ENST00000346301.4_Missense_Mutation_p.F297L|TTC8_ENST00000380656.2_Missense_Mutation_p.F337L|TTC8_ENST00000354441.6_Missense_Mutation_p.F72L|TTC8_ENST00000536576.1_Missense_Mutation_p.F98L|TTC8_ENST00000345383.5_Missense_Mutation_p.F327L			Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8	363					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						GCAACCACTTCTATTCTGATC	0.363000													94	131					0	0	0.323286	0	0
CROCCP2	84809	broad.mit.edu	37	1	16958063	16958063	+	RNA	SNP	C	C	T	rs2779441	by1000genomes	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:16958063C>T	ENST00000412962.1	-	0	74																											AGCCCCTCTCCATCCTCTGTC	0.652000													3	7					0	0	0.150653	0	0
MALAT1	378938	broad.mit.edu	37	11	65271994	65271994	+	RNA	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65271994G>C	ENST00000534336.1	+	0	6762					NR_002819.2																						GCTGAGTGTTGAGGAAATTTC	0.373000													10	25					0	0	0.105934	0	0
ANKRD16	54522	broad.mit.edu	37	10	5925115	5925115	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:5925115C>T	ENST00000380094.5	-	5	1246	c.703G>A	c.(703-705)Gaa>Aaa	p.E235K	ANKRD16_ENST00000380092.4_Missense_Mutation_p.E235K|ANKRD16_ENST00000191063.8_Missense_Mutation_p.E235K	NM_019046.2	NP_061919.1	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16	235										breast(1)|endometrium(1)|large_intestine(5)|lung(3)|stomach(2)	12						AGGCTGTCTTCTGCTGAAAGG	0.542000													6	31					0	0	0.335167	0	0
CDH23	64072	broad.mit.edu	37	10	73464806	73464806	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:73464806A>G	ENST00000224721.6	+	24	2892	c.2887A>G	c.(2887-2889)Atc>Gtc	p.I963V	CDH23_ENST00000299366.7_Missense_Mutation_p.I1003V	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	958	Cadherin 9.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CCGCGAGCGCATCGCGGAGTA	0.677000													18	41					0	0	0.249174	0	0
TRIP12	9320	broad.mit.edu	37	2	230636274	230636274	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:230636274G>C	ENST00000283943.5	-	38	5722	c.5544C>G	c.(5542-5544)gtC>gtG	p.V1848V	TRIP12_ENST00000389044.4_Silent_p.V1896V|TRIP12_ENST00000389045.3_Silent_p.V1578V	NM_001284214.1|NM_004238.1	NP_001271143.1|NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1848					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TGAGTGGGAAGACTGATTCAA	0.378000													5	47					0	0	0.217242	0	0
SLC2A10	81031	broad.mit.edu	37	20	45354826	45354826	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:45354826C>T	ENST00000359271.2	+	2	1401	c.1151C>T	c.(1150-1152)tCa>tTa	p.S384L		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	384						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				GGAGACCCCTCAGCCCCTCCT	0.632000													12	57					0	0	0.119110	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6098634	6098634	+	Translation_Start_Site	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:6098634G>C	ENST00000536084.1	-	0	161				EIF2AK1_ENST00000199389.6_Missense_Mutation_p.I27M			Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 1						negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		CGGGAAAGTCGATGGCCGGCG	0.741000													3	6					0	0	0.150653	0	0
GLDC	2731	broad.mit.edu	37	9	6540106	6540106	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:6540106G>C	ENST00000321612.6	-	22	2760	c.2610C>G	c.(2608-2610)ttC>ttG	p.F870L		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	870					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CAGACTTTTTGAAGGGTCTCG	0.448000													19	90					0	0	0.219247	0	0
CCDC120	90060	broad.mit.edu	37	X	48925163	48925163	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:48925163G>T	ENST00000376396.3	+	10	1627	c.1408G>T	c.(1408-1410)Gag>Tag	p.E470*	CCDC120_ENST00000536628.2_Nonsense_Mutation_p.E458*|CCDC120_ENST00000597275.1_Nonsense_Mutation_p.E470*|CCDC120_ENST00000422185.2_Nonsense_Mutation_p.E470*|CCDC120_ENST00000603986.1_Nonsense_Mutation_p.E505*|CCDC120_ENST00000496529.2_Nonsense_Mutation_p.E470*	NM_001271835.1|NM_001271836.1|NM_033626.2	NP_001258764.1|NP_001258765.1|NP_296375.1	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120	470	Pro-rich.						protein binding			breast(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14						GCCTGCAGCTGAGGTCCCAGG	0.682000													7	8					0.27861	0.280034	0.278610	1	0
DIDO1	11083	broad.mit.edu	37	20	61541311	61541311	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:61541311C>T	ENST00000266070.4	-	4	1226	c.901G>A	c.(901-903)Gag>Aag	p.E301K	DIDO1_ENST00000395335.2_Missense_Mutation_p.E301K|DIDO1_ENST00000370371.4_Missense_Mutation_p.E301K|DIDO1_ENST00000370368.1_Missense_Mutation_p.E301K|DIDO1_ENST00000395340.1_Missense_Mutation_p.E301K|DIDO1_ENST00000395343.1_Missense_Mutation_p.E301K|DIDO1_ENST00000266071.5_Missense_Mutation_p.E301K|DIDO1_ENST00000370366.1_Missense_Mutation_p.E301K|DIDO1_ENST00000354665.4_Missense_Mutation_p.E301K	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	301					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CCTCGAGCCTCAGAAATGCCC	0.453000													25	63					0	0	0.396831	0	0
FRG1B	284802	broad.mit.edu	37	20	29625891	29625891	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:29625891C>G	ENST00000278882.3	+	5	515	c.135C>G	c.(133-135)ggC>ggG	p.G45G	FRG1B_ENST00000439954.2_Silent_p.G50G|FRG1B_ENST00000358464.4_Silent_p.G45G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TGAAATCTGGCTATGGAAAAT	0.343000													3	87					0	0	0.184627	0	0
HGF	3082	broad.mit.edu	37	7	81346648	81346648	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:81346648C>G	ENST00000222390.5	-	11	1531	c.1305G>C	c.(1303-1305)ctG>ctC	p.L435L	HGF_ENST00000457544.2_Silent_p.L430L	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	435	Kringle 4.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						AATTCTCATTCAGCTTACTTG	0.438000													43	87					0	0	0.323286	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30722721	30722721	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:30722721G>T	ENST00000215790.7	-	1	314	c.150C>A	c.(148-150)ttC>ttA	p.F50L	TBC1D10A_ENST00000403477.3_Missense_Mutation_p.F50L|TBC1D10A_ENST00000490449.1_5'UTR	NM_031937.2	NP_114143.1	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	50						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity	p.F50F(1)		cervix(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						GGCGCTCGGCGAAGCCGTTGG	0.711000													19	32					2.41591e-17	2.70472e-17	0.309145	1	0
C1orf173	127254	broad.mit.edu	37	1	75065450	75065450	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:75065450G>A	ENST00000326665.5	-	11	1873	c.1655C>T	c.(1654-1656)cCa>cTa	p.P552L	C1orf173_ENST00000420661.2_Missense_Mutation_p.P355L|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	552	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						ACGGGCATCTGGTGCCTTCTG	0.408000													43	102					0	0	0.279185	0	0
HIST1H2AG	8969	broad.mit.edu	37	6	27100906	27100906	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:27100906C>T	ENST00000359193.2	+	1	75	c.56C>T	c.(55-57)tCt>tTt	p.S19F		NM_021064.4	NP_066408.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	19					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	17						AAGACTCGCTCTTCTAGGGCC	0.642000													24	34					0	0	0.338820	0	0
BSN	8927	broad.mit.edu	37	3	49691151	49691151	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49691151C>A	ENST00000296452.4	+	5	4276	c.4162C>A	c.(4162-4164)Cct>Act	p.P1388T		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1388					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGCTGTGGCTCCTTGTCCAGC	0.622000													32	62					4.3181e-19	4.89938e-19	0.173368	1	0
KIAA1468	57614	broad.mit.edu	37	18	59855231	59855231	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:59855231G>T	ENST00000256858.6	+	1	741	c.493G>T	c.(493-495)Gaa>Taa	p.E165*	KIAA1468_ENST00000398130.2_Nonsense_Mutation_p.E165*			Q9P260	K1468_HUMAN	KIAA1468	165							binding			autonomic_ganglia(1)|breast(4)|endometrium(4)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47		Colorectal(73;0.186)				TGGAGGTCGGGAACCGAGTAC	0.652000											OREG0025032	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	14					0.150653	0.151682	0.150653	1	0
USP33	23032	broad.mit.edu	37	1	78187599	78187599	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:78187599G>A	ENST00000370793.1	-	15	2013	c.1667C>T	c.(1666-1668)tCa>tTa	p.S556L	USP33_ENST00000357428.1_Missense_Mutation_p.S556L|USP33_ENST00000370792.3_Intron|USP33_ENST00000370794.3_Missense_Mutation_p.S525L	NM_015017.4	NP_055832.3	Q8TEY7	UBP33_HUMAN	ubiquitin specific peptidase 33	556					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	44						AGGGACACATGAGACAACAAA	0.373000													14	29					0	0	0.132662	0	0
ASPRV1	151516	broad.mit.edu	37	2	70188237	70188237	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:70188237C>T	ENST00000320256.4	-	1	1160	c.584G>A	c.(583-585)gGc>gAc	p.G195D		NM_152792.2	NP_690005.2	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1	195					protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			endometrium(3)|large_intestine(4)|lung(6)|ovary(1)	14						GAGATAGTAGCCCTTACCCAT	0.602000													26	48					0	0	0.193644	0	0
XPO5	57510	broad.mit.edu	37	6	43516011	43516011	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:43516011G>A	ENST00000265351.7	-	18	2257	c.2047C>T	c.(2047-2049)Caa>Taa	p.Q683*		NM_020750.2	NP_065801.1	Q9HAV4	XPO5_HUMAN	exportin 5	683					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(4)|lung(10)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	34	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			TGCATGTCTTGAGAAAGCCAG	0.502000													22	94					0	0	0.324025	0	0
MALAT1	378938	broad.mit.edu	37	11	65273619	65273619	+	RNA	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65273619G>T	ENST00000534336.1	+	0	8387					NR_002819.2																						TGGTTTCCAGGACGGGGTTCA	0.423000													10	23					3.86212e-05	3.99063e-05	0.361761	1	0
ITGAX	3687	broad.mit.edu	37	16	31391116	31391116	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:31391116C>T	ENST00000268296.4	+	25	3028	c.2907C>T	c.(2905-2907)atC>atT	p.I969I	ITGAX_ENST00000562522.1_Silent_p.I969I	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	969					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						CTGTCAGCATCAACTTCTGGG	0.617000													8	24					0	0	0.387290	0	0
KMT2D	8085	broad.mit.edu	37	12	49448457	49448457	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:49448457A>G	ENST00000301067.7	-	3	253	c.254T>C	c.(253-255)tTt>tCt	p.F85S		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TGGCAACTCAAAGCGCCGTAG	0.622000													3	10					0	0	0.115264	0	0
TSPAN1	10103	broad.mit.edu	37	1	46651197	46651197	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:46651197C>G	ENST00000372003.1	+	9	1182	c.718C>G	c.(718-720)Cta>Gta	p.L240V		NM_005727.3	NP_005718.2	O60635	TSN1_HUMAN	tetraspanin 1	240						integral to membrane|lysosomal membrane				kidney(1)|large_intestine(1)|lung(5)|ovary(1)	8	Acute lymphoblastic leukemia(166;0.155)	Medulloblastoma(700;0.00498)|all_neural(321;0.0212)				GTACTGCAATCTACAATAAGT	0.542000													46	236					0	0	0.323286	0	0
INF2	64423	broad.mit.edu	37	14	105173276	105173276	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:105173276C>G	ENST00000392634.4	+	7	985	c.873C>G	c.(871-873)ctC>ctG	p.L291L	INF2_ENST00000330634.7_Silent_p.L291L	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	291	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CTGCCCAGCTCCTGTCGGTGC	0.706000													15	22					0	0	0.189662	0	0
SLTM	79811	broad.mit.edu	37	15	59191829	59191829	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:59191829C>A	ENST00000380516.2	-	7	984	c.897G>T	c.(895-897)atG>atT	p.M299I	SLTM_ENST00000536328.1_Intron	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	299					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding	p.M299I(2)		breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GGTTCGCATTCATCTCATAAT	0.448000													37	118					1.48734e-19	1.70064e-19	0.312237	1	0
ARFGAP1	55738	broad.mit.edu	37	20	61907473	61907473	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:61907473C>G	ENST00000370275.4	+	3	183	c.91C>G	c.(91-93)Cag>Gag	p.Q31E	ARFGAP1_ENST00000353546.3_Missense_Mutation_p.Q31E|ARFGAP1_ENST00000519273.2_5'UTR|ARFGAP1_ENST00000519604.1_Intron|ARFGAP1_ENST00000547204.1_Intron|ARFGAP1_ENST00000370283.4_Missense_Mutation_p.Q31E	NM_001281482.1	NP_001268411.1	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating protein 1	31	Arf-GAP.				COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)	13	all_cancers(38;1.59e-09)					GTTCAATCCTCAGTGGGTCAG	0.617000													85	154					0	0	0.323286	0	0
NR1H2	7376	broad.mit.edu	37	19	50881884	50881884	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:50881884C>A	ENST00000253727.5	+	6	813	c.578C>A	c.(577-579)tCa>tAa	p.S193*	NR1H2_ENST00000599105.1_Nonsense_Mutation_p.S193*|NR1H2_ENST00000411902.2_Nonsense_Mutation_p.S96*|NR1H2_ENST00000593926.1_Nonsense_Mutation_p.S193*|NR1H2_ENST00000542413.1_5'UTR|NR1H2_ENST00000598168.1_Nonsense_Mutation_p.S193*	NM_007121.5	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	193	Poly-Ser.				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	8		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		AGCAGCAGCTCAGCCTCTGGG	0.607000													16	17					7.05477e-17	7.85342e-17	0.160694	1	0
CERS6	253782	broad.mit.edu	37	2	169313067	169313067	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:169313067G>T	ENST00000305747.6	+	1	696	c.109G>T	c.(109-111)Gac>Tac	p.D37Y	CERS6_ENST00000392687.4_Missense_Mutation_p.D37Y	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	37						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GCAGGCTGAGGACCTCTATCT	0.597000													19	59					3.83957e-06	3.99532e-06	0.264190	1	0
KNTC1	9735	broad.mit.edu	37	12	123095437	123095437	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:123095437C>T	ENST00000333479.7	+	53	5789	c.5612C>T	c.(5611-5613)tCa>tTa	p.S1871L	KNTC1_ENST00000436959.3_5'UTR|KNTC1_ENST00000537348.1_Missense_Mutation_p.S296L|KNTC1_ENST00000450485.2_Missense_Mutation_p.S796L	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1871					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TTTGCAACATCAACTACAACC	0.333000													12	47					0	0	0.132662	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64607917	64607917	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:64607917C>A	ENST00000498707.1	-	18	2985	c.2643G>T	c.(2641-2643)tgG>tgT	p.W881C	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.W853C	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	881	TSP type-1 2.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CATGACTGTTCCAGTAAAACT	0.393000													35	68					1.57945e-13	1.71617e-13	0.301197	1	0
CHKB	1120	broad.mit.edu	37	22	51019955	51019955	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:51019955G>A	ENST00000406938.2	-	4	692	c.475C>T	c.(475-477)Cga>Tga	p.R159*	CHKB_ENST00000463053.1_5'UTR	NM_005198.4	NP_005189.2	Q9Y259	CHKB_HUMAN	choline kinase beta	159					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(5)|ovary(3)|skin(1)|urinary_tract(1)	15		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	ACTGGCTCTCGAAGCTCTTGA	0.572000													11	35					0	0	0.105934	0	0
MYH7	4625	broad.mit.edu	37	14	23891402	23891402	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23891402C>G	ENST00000355349.3	-	25	3394	c.3232G>C	c.(3232-3234)Gag>Cag	p.E1078Q		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1078					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTCAGCCGCTCATCCAGCTGC	0.592000													27	89					0	0	0.183431	0	0
COL20A1	57642	broad.mit.edu	37	20	61936830	61936830	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:61936830G>C	ENST00000422202.1	+	3	323	c.255G>C	c.(253-255)ctG>ctC	p.L85L	COL20A1_ENST00000326996.6_Silent_p.L85L|COL20A1_ENST00000435874.1_Silent_p.L85L|COL20A1_ENST00000358894.6_Silent_p.L85L			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	85	Fibronectin type-III 1.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					TGGGGGGCCTGAGCCCCTCCA	0.612000													8	11					0	0	0.387290	0	0
N6AMT1	29104	broad.mit.edu	37	21	30255367	30255367	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:30255367G>A	ENST00000303775.5	-	2	186	c.161C>T	c.(160-162)tCa>tTa	p.S54L	N6AMT1_ENST00000351429.3_Missense_Mutation_p.S54L	NM_013240.4	NP_037372	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1 (putative)	54	S-adenosyl-L-methionine binding (By similarity).				positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)	12						ACCAGACCCTGACCCTACTTC	0.368000													11	52					0	0	0.146539	0	0
KIF3C	3797	broad.mit.edu	37	2	26204403	26204403	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:26204403G>T	ENST00000264712.3	-	1	963	c.384C>A	c.(382-384)ttC>ttA	p.F128L	KIF3C_ENST00000405914.1_Missense_Mutation_p.F128L	NM_002254.6	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	128	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGATGTGGGTGAAGATGTGCT	0.602000													44	91					4.75821e-42	5.58121e-42	0.323286	1	0
TNIP2	79155	broad.mit.edu	37	4	2746230	2746230	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:2746230G>A	ENST00000510267.1	-	5	1016	c.589C>T	c.(589-591)Ctc>Ttc	p.L197F	TNIP2_ENST00000505186.1_5'UTR|TNIP2_ENST00000315423.7_Missense_Mutation_p.L304F|TNIP2_ENST00000503235.1_Missense_Mutation_p.L221F	NM_001161527.1	NP_001154999.1	Q8NFZ5	TNIP2_HUMAN	TNFAIP3 interacting protein 2	304						cytosol	protein binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(6)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTGTAAGCGAGAATCTGAAGA	0.552000													23	44					0	0	0.368089	0	0
TRBV5-7	28608	broad.mit.edu	37	7	142111558	142111558	+	RNA	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:142111558G>T	ENST00000390378.1	-	0	177																											TGGGGCCCCTGACCCAGGGCC	0.502000													16	84					3.41278e-10	3.66099e-10	0.160694	1	0
RYR2	6262	broad.mit.edu	37	1	237806646	237806646	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:237806646G>C	ENST00000366574.2	+	48	7558	c.7241G>C	c.(7240-7242)gGa>gCa	p.G2414A	RYR2_ENST00000360064.6_Missense_Mutation_p.G2412A|RYR2_ENST00000542537.1_Missense_Mutation_p.G2398A	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2414	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCCGGGAAGGGAGAAGCCATC	0.413000													37	139					0	0	0.323286	0	0
CCDC88A	55704	broad.mit.edu	37	2	55615938	55615938	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:55615938C>T	ENST00000436346.1	-	3	1090	c.249G>A	c.(247-249)gtG>gtA	p.V83V	CCDC88A_ENST00000413716.2_Silent_p.V83V|CCDC88A_ENST00000263630.8_Silent_p.V83V|CCDC88A_ENST00000336838.6_Silent_p.V83V	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	83					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						TTATCTGTCTCACCAAAATGG	0.294000													30	70					0	0	0.183431	0	0
INTS3	65123	broad.mit.edu	37	1	153713793	153713793	+	Silent	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:153713793C>A	ENST00000318967.2	+	3	835	c.267C>A	c.(265-267)atC>atA	p.I89I	INTS3_ENST00000435409.2_Silent_p.I89I|INTS3_ENST00000456435.1_5'UTR	NM_023015.3	NP_075391.3	Q68E01	INT3_HUMAN	integrator complex subunit 3	89					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			ATGAAGAAATCTGCCTGGGCC	0.493000													18	169					5.35047e-06	5.55771e-06	0.279207	1	0
C2CD3	26005	broad.mit.edu	37	11	73814626	73814626	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:73814626G>C	ENST00000334126.7	-	14	2356	c.2130C>G	c.(2128-2130)atC>atG	p.I710M	C2CD3_ENST00000313663.7_Missense_Mutation_p.I710M			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	710						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					ACTTAGTATTGATACCAGTGA	0.373000													26	47					0	0	0.309145	0	0
ANPEP	290	broad.mit.edu	37	15	90348636	90348636	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:90348636C>G	ENST00000300060.6	-	3	986	c.673G>C	c.(673-675)Gat>Cat	p.D225H		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	225	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GCCGGCTCATCGAAGCATGGG	0.607000													24	34					0	0	0.338820	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	70					0	0	0.115264	0	0
PHF3	23469	broad.mit.edu	37	6	64390047	64390047	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:64390047C>T	ENST00000262043.3	+	3	731	c.391C>T	c.(391-393)Cgt>Tgt	p.R131C	PHF3_ENST00000393387.1_Missense_Mutation_p.R131C|PHF3_ENST00000509330.1_Missense_Mutation_p.R131C			Q92576	PHF3_HUMAN	PHD finger protein 3	131					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AAAATCACCTCGTTTAATGGC	0.383000													18	93					0	0	0.234183	0	0
PRUNE	58497	broad.mit.edu	37	1	151001306	151001306	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:151001306C>G	ENST00000271620.3	+	7	975	c.819C>G	c.(817-819)ttC>ttG	p.F273L	PRUNE_ENST00000368937.1_Intron|PRUNE_ENST00000368935.1_Intron|PRUNE_ENST00000271619.8_Intron|PRUNE_ENST00000368936.1_Missense_Mutation_p.F91L|PRUNE_ENST00000467771.1_3'UTR|PRUNE_ENST00000368934.1_Intron	NM_021222.1	NP_067045.1	Q86TP1	PRUNE_HUMAN	prune exopolyphosphatase	273						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	14	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCCATGCTTTCTGCCAGGCTC	0.478000													16	109					0	0	0.219247	0	0
MALAT1	378938	broad.mit.edu	37	11	65272034	65272034	+	RNA	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65272034G>T	ENST00000534336.1	+	0	6802					NR_002819.2																						ATTTGTGATTGAAGCTGAGTA	0.393000													8	16					5.4927e-09	5.82859e-09	0.307466	1	0
TARDBP	23435	broad.mit.edu	37	1	11082686	11082686	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:11082686C>G	ENST00000240185.3	+	6	1334	c.1220C>G	c.(1219-1221)tCt>tGt	p.S407C	TARDBP_ENST00000315091.3_Intron|TARDBP_ENST00000439080.2_Missense_Mutation_p.S291C	NM_007375.3	NP_031401.1	Q13148	TADBP_HUMAN	TAR DNA binding protein	407	Gly-rich.				3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)	11	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		AGCATGGATTCTAAGTCTTCT	0.443000													26	146					0	0	0.257332	0	0
FAM129B	64855	broad.mit.edu	37	9	130269539	130269539	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:130269539G>A	ENST00000373312.3	-	14	2039	c.1826C>T	c.(1825-1827)tCa>tTa	p.S609L	FAM129B_ENST00000373314.3_Missense_Mutation_p.S596L|FAM129B_ENST00000468379.1_5'UTR	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	609							protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						GAGGGTGGCTGACTCCGGGGT	0.697000													15	12					0	0	0.175082	0	0
IQGAP1	8826	broad.mit.edu	37	15	91020904	91020904	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:91020904G>A	ENST00000268182.5	+	26	3236	c.3112G>A	c.(3112-3114)Gta>Ata	p.V1038I	IQGAP1_ENST00000560738.1_Missense_Mutation_p.V466I	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1038	C1.|Ras-GAP.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TAGGTCGAAGGTAGATCAGAT	0.393000													15	68					0	0	0.132662	0	0
NAALAD2	10003	broad.mit.edu	37	11	89896561	89896561	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:89896561G>A	ENST00000534061.1	+	10	1389	c.1159G>A	c.(1159-1161)Gaa>Aaa	p.E387K	NAALAD2_ENST00000525171.1_Missense_Mutation_p.E294K|NAALAD2_ENST00000321955.4_Missense_Mutation_p.E354K|NAALAD2_ENST00000375944.3_Intron	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	387	NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TGTTTTGCAAGAAATTGCCCG	0.398000													52	101					0	0	0.323286	0	0
CD300LF	146722	broad.mit.edu	37	17	72699199	72699199	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:72699199G>C	ENST00000469092.1	-	4	706	c.430C>G	c.(430-432)Ctg>Gtg	p.L144V	RAB37_ENST00000402449.4_Intron|CD300LF_ENST00000361254.4_Missense_Mutation_p.L159V|RAB37_ENST00000340415.3_Intron|CD300LF_ENST00000464910.1_Missense_Mutation_p.L144V|CD300LF_ENST00000301573.9_Missense_Mutation_p.L141V|CD300LF_ENST00000581500.1_Missense_Mutation_p.L159V|CD300LF_ENST00000326165.6_Missense_Mutation_p.L141V|CD300LF_ENST00000343125.4_Missense_Mutation_p.L144V|CD300LF_ENST00000583937.1_Missense_Mutation_p.L156V			Q8TDQ1	CLM1_HUMAN	CD300 molecule-like family member f	141						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						TGGCCGGTCAGAGTTGGGGAG	0.547000													11	104					0	0	0.105934	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25251339	25251339	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:25251339C>G	ENST00000328086.7	-	7	3505	c.2702G>C	c.(2701-2703)aGa>aCa	p.R901T		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	901					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		TTCTCGAAATCTCGTACAGTT	0.458000													13	29					0	0	0.132662	0	0
OR6K6	128371	broad.mit.edu	37	1	158724899	158724899	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:158724899G>A	ENST00000368144.2	+	1	390	c.294G>A	c.(292-294)gaG>gaA	p.E98E		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					CCTTCCTGGAGATCTGCTATA	0.483000													58	177					0	0	0.323286	0	0
ATP1A2	477	broad.mit.edu	37	1	160098495	160098495	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:160098495G>A	ENST00000361216.3	+	9	1160	c.1071G>A	c.(1069-1071)aaG>aaA	p.K357K	ATP1A2_ENST00000392233.3_Silent_p.K357K	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	357					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GCCTGGTGAAGAACCTGGAGG	0.592000													29	97					0	0	0.193644	0	0
GJB3	2707	broad.mit.edu	37	1	35250591	35250591	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:35250591C>T	ENST00000373366.2	+	2	843	c.228C>T	c.(226-228)ctC>ctT	p.L76L	RP1-34M23.5_ENST00000542839.1_RNA|GJB3_ENST00000373362.3_Silent_p.L76L	NM_024009.2	NP_076872.1	O75712	CXB3_HUMAN	gap junction protein, beta 3, 31kDa	76					cell communication	connexon complex|integral to membrane	gap junction channel activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(2)|prostate(3)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				ACATCCGCCTCTGGGCCCTGC	0.622000													12	22					0	0	0.387290	0	0
INTS5	80789	broad.mit.edu	37	11	62416959	62416959	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62416959G>A	ENST00000330574.2	-	2	645	c.593C>T	c.(592-594)tCg>tTg	p.S198L		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	198					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						AATGAGAGCCGAGAGGCACTG	0.532000													31	102					0	0	0.193644	0	0
HSCB	150274	broad.mit.edu	37	22	29138168	29138168	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:29138168G>T	ENST00000216027.3	+	1	150	c.85G>T	c.(85-87)Gat>Tat	p.D29Y	CHEK2_ENST00000544772.1_5'UTR|HSCB_ENST00000398941.2_Missense_Mutation_p.D29Y	NM_172002.3	NP_741999.3	Q8IWL3	HSC20_HUMAN	HscB mitochondrial iron-sulfur cluster co-chaperone	29					iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)|lung(2)|skin(1)	4						GCTAAGCTGCGATGCTGCGTC	0.682000													3	12					0.00909568	0.00928452	0.150653	1	0
BCL9	607	broad.mit.edu	37	1	147092562	147092562	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:147092562G>A	ENST00000234739.3	+	8	3341	c.2601G>A	c.(2599-2601)acG>acA	p.T867T		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	867	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					AGTCTCCCACGATGCACCAAG	0.637000			T	"""IGH@, IGL@"""	B-ALL								23	97					0	0	0.294199	0	0
UGT3A1	133688	broad.mit.edu	37	5	35965895	35965895	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:35965895C>T	ENST00000274278.3	-	4	793	c.436G>A	c.(436-438)Gca>Aca	p.A146T	UGT3A1_ENST00000507113.1_Missense_Mutation_p.A112T|UGT3A1_ENST00000513233.1_Intron|UGT3A1_ENST00000333811.4_Missense_Mutation_p.A92T|UGT3A1_ENST00000503189.1_Missense_Mutation_p.A146T	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	146						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAATCAAATGCTTCAACAAAT	0.383000													21	36					0	0	0.294199	0	0
HYDIN	54768	broad.mit.edu	37	16	71008159	71008159	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:71008159C>G	ENST00000393567.2	-	33	5104	c.4954G>C	c.(4954-4956)Gaa>Caa	p.E1652Q		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1652										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				ATTTCCGTTTCACAATGAGGT	0.428000													4	20					0	0	0.184627	0	0
HIST1H1T	3010	broad.mit.edu	37	6	26108038	26108038	+	Missense_Mutation	SNP	C	C	A	rs147905742		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:26108038C>A	ENST00000338379.4	-	1	326	c.284G>T	c.(283-285)gGa>gTa	p.G95V		NM_005323.3	NP_005314.2	P22492	H1T_HUMAN	histone cluster 1, H1t	95	H15.				cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			breast(2)|endometrium(1)|lung(3)|ovary(2)|prostate(1)	9						CACCAGGATTCCCTTGTTCAC	0.478000													23	55					1.17739e-12	1.27695e-12	0.324025	1	0
PPP2R5E	5529	broad.mit.edu	37	14	63851225	63851225	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:63851225G>C	ENST00000337537.3	-	12	1741	c.1139C>G	c.(1138-1140)tCt>tGt	p.S380C	PPP2R5E_ENST00000553266.1_5'UTR|PPP2R5E_ENST00000555899.1_Missense_Mutation_p.S380C|PPP2R5E_ENST00000422769.2_Missense_Mutation_p.S304C	NM_001282179.1|NM_001282180.1|NM_001282181.1|NM_001282182.1|NM_006246.2	NP_001269108.1|NP_001269109.1|NP_001269110.1|NP_001269111.1|NP_006237.1	Q16537	2A5E_HUMAN	protein phosphatase 2, regulatory subunit B', epsilon isoform	380					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|soft_tissue(1)	15				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		GATGACGTTAGAGTTTTCTTC	0.363000													47	123					0	0	0.323286	0	0
NPAT	4863	broad.mit.edu	37	11	108044182	108044182	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:108044182G>C	ENST00000278612.8	-	13	1634	c.1529C>G	c.(1528-1530)aCt>aGt	p.T510S	NPAT_ENST00000610253.1_5'UTR	NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	510					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		AACAAATGAAGTTATTGGTAT	0.363000													43	91					0	0	0.323286	0	0
CHD1	1105	broad.mit.edu	37	5	98215419	98215419	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:98215419G>C	ENST00000284049.3	-	22	3223	c.3074C>G	c.(3073-3075)tCa>tGa	p.S1025*		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1025					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ATCCATATTTGAGAAGTTGGC	0.343000													3	10					0	0	0.150653	0	0
SON	6651	broad.mit.edu	37	21	34927106	34927106	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:34927106C>T	ENST00000356577.4	+	3	6044	c.5569C>T	c.(5569-5571)Cat>Tat	p.H1857Y	SON_ENST00000290239.6_Missense_Mutation_p.H1857Y|SON_ENST00000381679.4_Missense_Mutation_p.H1857Y|SON_ENST00000300278.4_Missense_Mutation_p.H1857Y|SON_ENST00000381692.2_Intron	NM_138927.1	NP_620305	P18583	SON_HUMAN	SON DNA binding protein	1857					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						GTCCAAGTCTCATCGCTCTCA	0.448000													22	77					0	0	0.324025	0	0
ATP6V1B1	525	broad.mit.edu	37	2	71188791	71188791	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:71188791C>T	ENST00000234396.4	+	8	826	c.753C>T	c.(751-753)gtC>gtT	p.V251V	ATP6V1B1_ENST00000412314.1_Silent_p.V251V|AC007040.11_ENST00000606025.1_Intron	NM_001692.3	NP_001683.2	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	251					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(1)	19						TGGGGAACGTCTGCCTCTTCC	0.567000													32	64					0	0	0.257332	0	0
STS	412	broad.mit.edu	37	X	7268167	7268167	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:7268167G>C	ENST00000217961.4	+	10	1837	c.1617G>C	c.(1615-1617)caG>caC	p.Q539H		NM_000351.4	NP_000342.2	P08842	STS_HUMAN	steroid sulfatase (microsomal), isozyme S	539					female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(1)	27		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	GACACACCCAGACCCTGCCAG	0.542000									Ichthyosis				21	14					0	0	0.338820	0	0
DNAJC16	23341	broad.mit.edu	37	1	15890809	15890809	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:15890809C>G	ENST00000375847.3	+	11	1717	c.1553C>G	c.(1552-1554)tCt>tGt	p.S518C	DNAJC16_ENST00000375849.1_Missense_Mutation_p.S518C|DNAJC16_ENST00000375838.1_Missense_Mutation_p.S518C|DNAJC16_ENST00000483270.1_3'UTR	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	518					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TACTCTGCTTCTGACTACATC	0.433000													28	130					0	0	0.203993	0	0
CAPG	822	broad.mit.edu	37	2	85625866	85625866	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85625866C>A	ENST00000263867.4	-	7	955	c.706G>T	c.(706-708)Gag>Tag	p.E236*	CAPG_ENST00000483659.1_5'UTR|CAPG_ENST00000409921.1_Nonsense_Mutation_p.E221*|CAPG_ENST00000409670.1_Nonsense_Mutation_p.E236*|CAPG_ENST00000409724.1_Nonsense_Mutation_p.E236*	NM_001256140.1|NM_001747.3	NP_001243069.1|NP_001738.2	P40121	CAPG_HUMAN	capping protein (actin filament), gelsolin-like	236					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)	11						AGGTCTTCCTCAGGGTTGCCC	0.662000													5	17					0.0215528	0.0219244	0.217242	1	0
CLCF1	23529	broad.mit.edu	37	11	67134963	67134963	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:67134963C>G	ENST00000312438.7	-	2	348	c.151G>C	c.(151-153)Gag>Cag	p.E51Q	AP003419.11_ENST00000543494.1_RNA|CLCF1_ENST00000533438.1_Missense_Mutation_p.E41Q|CLCF1_ENST00000528474.1_Missense_Mutation_p.E41Q	NM_013246.2	NP_037378.1	Q9UBD9	CLCF1_HUMAN	cardiotrophin-like cytokine factor 1	51					B cell differentiation|cytokine-mediated signaling pathway|JAK-STAT cascade|negative regulation of neuron apoptosis|positive regulation of astrocyte differentiation|positive regulation of B cell proliferation|positive regulation of immunoglobulin production|positive regulation of isotype switching to IgE isotypes|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	ciliary neurotrophic factor receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			endometrium(1)|urinary_tract(1)	2			BRCA - Breast invasive adenocarcinoma(15;2.39e-06)			AGTTGGTGCTCCAGGTAGCGG	0.602000													37	97					0	0	0.268233	0	0
DNAJC16	23341	broad.mit.edu	37	1	15871058	15871058	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:15871058C>A	ENST00000375847.3	+	5	903	c.739C>A	c.(739-741)Cca>Aca	p.P247T	DNAJC16_ENST00000375849.1_Missense_Mutation_p.P247T|DNAJC16_ENST00000375838.1_Missense_Mutation_p.P247T	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	247	Thioredoxin.				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AAGTCTTCTTCCAGGGAACTT	0.423000													19	89					3.7963e-18	4.28264e-18	0.279207	1	0
NUTM1	256646	broad.mit.edu	37	15	34645971	34645971	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:34645971C>A	ENST00000537011.1	+	5	1355	c.973C>A	c.(973-975)Cag>Aag	p.Q325K	NUTM1_ENST00000438749.3_Missense_Mutation_p.Q315K|NUTM1_ENST00000333756.4_Missense_Mutation_p.Q297K	NM_001284292.1	NP_001271221.1			NUT midline carcinoma, family member 1																		GATGCAGATTCAGAACACACA	0.542000													41	59					6.14515e-18	6.89285e-18	0.323286	1	0
INPP5D	3635	broad.mit.edu	37	2	234079180	234079180	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:234079180G>A	ENST00000359570.5	+	18	1794	c.1794G>A	c.(1792-1794)caG>caA	p.Q598Q	INPP5D_ENST00000538935.1_3'UTR|INPP5D_ENST00000455936.2_Silent_p.Q362Q|INPP5D_ENST00000450745.1_Silent_p.Q362Q			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	610					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		AGCAGCAGCAGTACGCAGACC	0.582000													18	36					0	0	0.264190	0	0
CMTM2	146225	broad.mit.edu	37	16	66620940	66620940	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:66620940G>A	ENST00000268595.2	+	3	636	c.485G>A	c.(484-486)gGa>gAa	p.G162E	CMTM2_ENST00000379486.2_Missense_Mutation_p.G109E	NM_144673.2	NP_653274.1	Q8TAZ6	CKLF2_HUMAN	CKLF-like MARVEL transmembrane domain containing 2	162	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	17		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		TTCCTTGTGGGAGCCGTGGTC	0.522000													14	87					0	0	0.160694	0	0
PARP3	10039	broad.mit.edu	37	3	51979599	51979599	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:51979599G>T	ENST00000417220.2	+	8	1438	c.950G>T	c.(949-951)cGa>cTa	p.R317L	PARP3_ENST00000398755.3_Missense_Mutation_p.R324L|PARP3_ENST00000431474.1_Missense_Mutation_p.R317L			Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	317	PARP catalytic.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCCCTGGACCGAGACTACCAG	0.627000													32	61					1.59932e-28	1.85748e-28	0.257332	1	0
KRT12	3859	broad.mit.edu	37	17	39017927	39017927	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:39017927C>T	ENST00000251643.4	-	8	1494	c.1471G>A	c.(1471-1473)Gaa>Aaa	p.E491K	RP5-1110E20.1_ENST00000579136.1_RNA	NM_000223.3	NP_000214.1	Q99456	K1C12_HUMAN	keratin 12	491	Tail.				visual perception	intermediate filament	structural molecule activity	p.E491Q(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	15		Breast(137;0.000301)				ATTAGTTCTTCAATTTCCTGA	0.373000													9	57					0	0	0.132662	0	0
OR2L13	284521	broad.mit.edu	37	1	248263467	248263467	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:248263467C>T	ENST00000366478.2	+	3	1127	c.790C>T	c.(790-792)Ctc>Ttc	p.L264F	OR2L13_ENST00000358120.2_Missense_Mutation_p.L264F	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding	p.L264I(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			GCCCAGGAATCTCCGCTCACC	0.468000													37	88					0	0	0.301197	0	0
ANPEP	290	broad.mit.edu	37	15	90348336	90348336	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:90348336C>T	ENST00000300060.6	-	4	1183	c.870G>A	c.(868-870)gtG>gtA	p.V290V		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	290	Interaction with HCoV-229E.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CCTGCTTCTCCACGTAGTCGA	0.562000													45	105					0	0	0.323286	0	0
BTBD2	55643	broad.mit.edu	37	19	2015370	2015370	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:2015370G>T	ENST00000255608.4	-	1	349	c.333C>A	c.(331-333)ttC>ttA	p.F111L	BTBD2_ENST00000590646.1_Intron	NM_017797.3	NP_060267.2	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	111						cytoplasmic mRNA processing body	protein binding			endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)	12		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCGTTGTTGAAGAGGAAGG	0.731000													5	22					0.0381472	0.0386053	0.278610	1	0
SLC35F2	54733	broad.mit.edu	37	11	107673745	107673745	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:107673745G>C	ENST00000525071.1	-	10	1509	c.921C>G	c.(919-921)ctC>ctG	p.L307L	SLC35F2_ENST00000429869.1_Silent_p.L307L|SLC35F2_ENST00000375682.4_Silent_p.L260L|SLC35F2_ENST00000525815.1_Silent_p.L307L|SLC35F2_ENST00000265836.7_Silent_p.L159L			Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	307					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		CAAACAGAAAGAGTCCAACAA	0.428000													18	42					0	0	0.219247	0	0
SLC23A3	151295	broad.mit.edu	37	2	220034634	220034634	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:220034634G>A	ENST00000455516.2	-	1	120	c.73C>T	c.(73-75)Cca>Tca	p.P25S	SLC23A3_ENST00000396775.3_5'UTR|SLC23A3_ENST00000295738.7_Missense_Mutation_p.P25S|SLC23A3_ENST00000409878.3_Missense_Mutation_p.P25S	NM_001144890.1	NP_001138362.1	Q6PIS1	S23A3_HUMAN	solute carrier family 23, member 3	25					transmembrane transport	integral to membrane	protein binding|transporter activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	11		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAGCAGGTGGAGGCAAGGGG	0.617000													4	35					0	0	0.150653	0	0
PCDH12	51294	broad.mit.edu	37	5	141334867	141334867	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:141334867G>C	ENST00000231484.3	-	1	3760	c.2550C>G	c.(2548-2550)ttC>ttG	p.F850L		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	850					neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGATGGTTGAAAAGGAGGT	0.627000													18	70					0	0	0.249174	0	0
ATP8B1	5205	broad.mit.edu	37	18	55351301	55351301	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:55351301C>G	ENST00000536015.1	-	15	1716	c.1597G>C	c.(1597-1599)Gtt>Ctt	p.V533L	RP11-35G9.3_ENST00000599199.1_RNA|ATP8B1_ENST00000283684.4_Missense_Mutation_p.V533L|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	533					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				GTGTGGCAAACTGCGAGCAAG	0.448000													13	69					0	0	0.175082	0	0
CSDE1	7812	broad.mit.edu	37	1	115262243	115262243	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:115262243G>A	ENST00000438362.2	-	18	2689	c.2311C>T	c.(2311-2313)Cag>Tag	p.Q771*	CSDE1_ENST00000534699.1_Nonsense_Mutation_p.Q725*|CSDE1_ENST00000261443.5_Nonsense_Mutation_p.Q694*|CSDE1_ENST00000530886.1_Nonsense_Mutation_p.Q595*|CSDE1_ENST00000339438.6_Nonsense_Mutation_p.Q694*|CSDE1_ENST00000369530.1_Nonsense_Mutation_p.Q740*|CSDE1_ENST00000358528.4_Nonsense_Mutation_p.Q725*	NM_001242891.1	NP_001229820.1	O75534	CSDE1_HUMAN	cold shock domain containing E1, RNA-binding	725					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			NS(1)|breast(4)|endometrium(11)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	51	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAGTGCGCTGATTAAGAATC	0.448000													24	101					0	0	0.324025	0	0
RABGGTA	5875	broad.mit.edu	37	14	24737148	24737148	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:24737148G>A	ENST00000399409.3	-	12	1647	c.1164C>T	c.(1162-1164)atC>atT	p.I388I	RABGGTA_ENST00000216840.6_Silent_p.I388I|RABGGTA_ENST00000560777.1_5'UTR	NM_004581.5	NP_004572.3	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase, alpha subunit	388					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	12				GBM - Glioblastoma multiforme(265;0.0184)		TCAGCAGGATGATGGTAAGCA	0.577000													12	32					0	0	0.132662	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85450069	85450069	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:85450069G>A	ENST00000393217.2	+	8	1559	c.1498G>A	c.(1498-1500)Gaa>Aaa	p.E500K		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	500										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		GGTCAAGCAAGAAAGAAAATA	0.303000													10	37					0	0	0.105934	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202920093	202920093	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:202920093C>G	ENST00000340990.5	-	2	404	c.106G>C	c.(106-108)Gag>Cag	p.E36Q	ADIPOR1_ENST00000367254.3_Missense_Mutation_p.E36Q|ADIPOR1_ENST00000436244.1_Missense_Mutation_p.E36Q	NM_015999.4	NP_057083.2	Q96A54	ADR1_HUMAN	adiponectin receptor 1	36					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			TTGCCCTTCTCTTCTAGCAGG	0.527000													16	148					0	0	0.175082	0	0
NR1D2	9975	broad.mit.edu	37	3	24003755	24003755	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:24003755C>G	ENST00000312521.4	+	5	1124	c.805C>G	c.(805-807)Caa>Gaa	p.Q269E	NR1D2_ENST00000492552.1_3'UTR	NM_001145425.1|NM_005126.4	NP_001138897.1|NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	269					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			NS(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	22						TATGTATAATCAAGAGCAGCA	0.423000													12	50					0	0	0.119110	0	0
PEBP4	157310	broad.mit.edu	37	8	22570973	22570973	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:22570973C>G	ENST00000256404.6	-	7	685	c.594G>C	c.(592-594)caG>caC	p.Q198H	RP11-459E5.1_ENST00000523627.1_RNA	NM_144962.2	NP_659399.2	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	198						lysosome				breast(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|stomach(2)	10		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		CCTGGTAGTTCTGGGTCATGA	0.557000													8	18					0	0	0.278610	0	0
PCDHA12	56137	broad.mit.edu	37	5	140257094	140257094	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:140257094G>A	ENST00000398631.2	+	1	2037	c.2037G>A	c.(2035-2037)tcG>tcA	p.S679S	PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron	NM_018903.2|NM_031864.2	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAAGACGTCGTCGCGGGCCT	0.657000													3	37					0	0	0.115264	0	0
OR5H1	26341	broad.mit.edu	37	3	97852160	97852160	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:97852160C>G	ENST00000354565.2	+	1	619	c.619C>G	c.(619-621)Cag>Gag	p.Q207E	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						AGGTTCAATTCAGGTATTCAG	0.313000													6	33					0	0	0.248553	0	0
KCNT1	57582	broad.mit.edu	37	9	138650273	138650273	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:138650273G>A	ENST00000298480.5	+	10	847	c.773G>A	c.(772-774)cGt>cAt	p.R258H	KCNT1_ENST00000488444.2_Missense_Mutation_p.R239H|KCNT1_ENST00000490355.2_Missense_Mutation_p.R239H|KCNT1_ENST00000486577.2_Missense_Mutation_p.R219H|KCNT1_ENST00000487664.1_Missense_Mutation_p.R210H|KCNT1_ENST00000491806.2_Missense_Mutation_p.R225H|KCNT1_ENST00000263604.3_Missense_Mutation_p.R239H|KCNT1_ENST00000371757.2_Missense_Mutation_p.R258H			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	258						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GACTTCCACCGTGCCATCCTG	0.587000													17	81					0	0	0.249174	0	0
LRRC8D	55144	broad.mit.edu	37	1	90400866	90400866	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:90400866G>C	ENST00000337338.5	+	3	2646	c.2239G>C	c.(2239-2241)Gaa>Caa	p.E747Q	LRRC8D_ENST00000394593.3_Missense_Mutation_p.E747Q	NM_001134479.1	NP_001127951.1	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member D	747						integral to membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(2)|skin(1)	29		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		GATTCCAATAGAAATAGGATT	0.373000													19	73					0	0	0.189662	0	0
PPAP2A	8611	broad.mit.edu	37	5	54721117	54721117	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:54721117C>G	ENST00000307259.8	-	6	1192	c.772G>C	c.(772-774)Gaa>Caa	p.E258Q	PPAP2A_ENST00000264775.5_Missense_Mutation_p.E259Q|SKIV2L2_ENST00000230640.5_3'UTR	NM_003711.2	NP_003702.2	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A	258					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	9		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				TCTTTTCTTTCTTTAAAAGAA	0.378000													6	39					0	0	0.278610	0	0
ASPRV1	151516	broad.mit.edu	37	2	70188460	70188460	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:70188460C>G	ENST00000320256.4	-	1	937	c.361G>C	c.(361-363)Gaa>Caa	p.E121Q		NM_152792.2	NP_690005.2	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1	121					protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			endometrium(3)|large_intestine(4)|lung(6)|ovary(1)	14						TTGATGACTTCAAAGCTGTGC	0.562000													13	54					0	0	0.132662	0	0
USP6	9098	broad.mit.edu	37	17	5041507	5041507	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:5041507C>T	ENST00000574788.1	+	21	3247	c.1017C>T	c.(1015-1017)ctC>ctT	p.L339L	USP6_ENST00000332776.4_Silent_p.L339L|USP6_ENST00000250066.6_Silent_p.L339L|USP6_ENST00000304328.5_5'UTR			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	339					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						ACACCGTGCTCAAGCATCTTA	0.577000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								30	93					0	0	0.396831	0	0
MYT1L	23040	broad.mit.edu	37	2	1914104	1914104	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:1914104C>G	ENST00000399161.2	-	13	2472	c.1725G>C	c.(1723-1725)ccG>ccC	p.P575P	MYT1L_ENST00000428368.2_Silent_p.P573P	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	575					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTGCAGCGATCGGGCATCCGG	0.587000													22	51					0	0	0.279207	0	0
IRAK4	51135	broad.mit.edu	37	12	44176171	44176171	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:44176171G>C	ENST00000431837.1	+	8	939	c.631G>C	c.(631-633)Gct>Cct	p.A211P	IRAK4_ENST00000551736.1_Missense_Mutation_p.A335P|IRAK4_ENST00000440781.2_Missense_Mutation_p.A211P|IRAK4_ENST00000448290.2_Missense_Mutation_p.A335P	NM_001145256.1|NM_001145257.1	NP_001138728.1|NP_001138729.1	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	335	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity					all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		CCTTGCACGGGCTTCTGAGAA	0.388000													16	41					0	0	0.204396	0	0
MAP3K4	4216	broad.mit.edu	37	6	161527697	161527697	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:161527697G>C	ENST00000392142.4	+	20	4156	c.4008G>C	c.(4006-4008)ttG>ttC	p.L1336F	MAP3K4_ENST00000348824.7_Missense_Mutation_p.L1282F|MAP3K4_ENST00000366919.2_Missense_Mutation_p.L1286F|MAP3K4_ENST00000366920.2_Missense_Mutation_p.L1332F	NM_005922.2	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1336					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		ACGTTGGCTTGAGGAAGGTGA	0.378000													38	50					0	0	0.323286	0	0
SMARCB1	6598	broad.mit.edu	37	22	24175882	24175882	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:24175882G>T	ENST00000344921.6	+	8	1344	c.1137G>T	c.(1135-1137)agG>agT	p.R379S	SMARCB1_ENST00000263121.7_Missense_Mutation_p.R370S|SMARCB1_ENST00000407422.3_Missense_Mutation_p.R361S|SMARCB1_ENST00000407082.3_Missense_Mutation_p.R324S			Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	370					cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(2)|p.L266_*386del(1)		bone(4)|central_nervous_system(198)|endometrium(4)|haematopoietic_and_lymphoid_tissue(25)|kidney(3)|large_intestine(5)|liver(2)|lung(5)|meninges(5)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|soft_tissue(194)	458		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				ACCAGGACAGGAACACGAGGT	0.622000			"""D, N, F, S"""		malignant rhabdoid	malignant rhabdoid							17	38					1.15919e-05	1.20197e-05	0.204396	1	0
ZRSR1	7310	broad.mit.edu	37	5	112227372	112227372	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:112227372G>C	ENST00000391338.1	+	1	60	c.36G>C	c.(34-36)aaG>aaC	p.K12N	REEP5_ENST00000513339.1_Intron|CTC-487M23.8_ENST00000506997.1_3'UTR|CTC-487M23.8_ENST00000512790.1_3'UTR|REEP5_ENST00000474542.2_Intron|REEP5_ENST00000504247.1_Intron|REEP5_ENST00000379638.4_Intron|REEP5_ENST00000545426.1_Intron	NM_001204199.1	NP_001191128.1			zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1											breast(1)|skin(1)|stomach(2)	4						TTCCCAAGAAGATGACATTTC	0.478000													4	11					0	0	0.150653	0	0
MEGF10	84466	broad.mit.edu	37	5	126771180	126771180	+	Splice_Site	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:126771180A>G	ENST00000274473.6	+	17	2370	c.2103A>G	c.(2101-2103)caA>caG	p.Q701Q	MEGF10_ENST00000503335.2_Splice_Site_p.Q701Q	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	701	Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ACTGCTCTCAACGTAAGTCTT	0.378000													7	35					0	0	0.307466	0	0
CCDC171	203238	broad.mit.edu	37	9	15623317	15623317	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:15623317C>G	ENST00000380701.3	+	7	1056	c.728C>G	c.(727-729)aCa>aGa	p.T243R	CCDC171_ENST00000535968.1_Missense_Mutation_p.T243R|CCDC171_ENST00000297641.3_Missense_Mutation_p.T243R	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	243	Glu-rich.																AAATTAGAAACAGAACATATG	0.348000													15	72					0	0	0.175082	0	0
SORCS3	22986	broad.mit.edu	37	10	107007054	107007054	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:107007054G>C	ENST00000369701.3	+	22	3297	c.3070G>C	c.(3070-3072)Gat>Cat	p.D1024H	SORCS3_ENST00000369699.4_3'UTR	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1024						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GTGGAGAAAAGATATTGGCAA	0.383000													24	46					0	0	0.382532	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43919692	43919692	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:43919692C>T	ENST00000282406.4	+	4	336	c.226C>T	c.(226-228)Caa>Taa	p.Q76*		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	76						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGCTAATATTCAAACCAGTGA	0.308000													18	109					0	0	0.234183	0	0
MALAT1	378938	broad.mit.edu	37	11	65273757	65273757	+	RNA	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65273757G>C	ENST00000534336.1	+	0	8525					NR_002819.2																						CAATATCTTTGAACTATATAC	0.378000													11	34					0	0	0.146539	0	0
DNMT1	1786	broad.mit.edu	37	19	10287981	10287981	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:10287981G>C	ENST00000340748.4	-	5	743	c.508C>G	c.(508-510)Cat>Gat	p.H170D	DNMT1_ENST00000540357.1_Missense_Mutation_p.H170D|DNMT1_ENST00000359526.4_Missense_Mutation_p.H186D			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	170	Interaction with DNMT3B.|Interaction with PCNA.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TTTGCAAAATGAGATGTGATG	0.438000													7	36					0	0	0.335167	0	0
SLC14A2	8170	broad.mit.edu	37	18	43206949	43206949	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:43206949G>C	ENST00000255226.6	+	4	1174	c.358G>C	c.(358-360)Gac>Cac	p.D120H	SLC14A2_ENST00000586448.1_Missense_Mutation_p.D120H	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	120						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCAGTTCATAGACTGGGTCCT	0.557000													18	78					0	0	0.234183	0	0
MALAT1	378938	broad.mit.edu	37	11	65273364	65273364	+	RNA	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65273364G>T	ENST00000534336.1	+	0	8132					NR_002819.2																						ATAGGCATTTGAGTGGCTGAG	0.423000													28	70					2.68265e-12	2.90415e-12	0.173368	1	0
CUX1	1523	broad.mit.edu	37	7	101923386	101923386	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:101923386G>C	ENST00000437600.4	+	19	2084	c.1732G>C	c.(1732-1734)Gac>Cac	p.D578H	CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000393824.3_Missense_Mutation_p.D541H|CUX1_ENST00000292538.4_Missense_Mutation_p.D580H|CUX1_ENST00000425244.2_Missense_Mutation_p.D534H|CUX1_ENST00000547394.2_Missense_Mutation_p.D564H	NM_181500.2	NP_852477.1	P39880	CUX1_HUMAN	cut-like homeobox 1	169					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						GGAGCGCCTGGACCCCTTCTC	0.662000													22	56					0	0	0.309145	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056443	26056443	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:26056443C>G	ENST00000343677.2	-	1	256	c.214G>C	c.(214-216)Gat>Cat	p.D72H		NM_005319.3	NP_005310.1	P16403	H12_HUMAN	histone cluster 1, H1c	72	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	34						TTCTCCACATCATAGCCGGCG	0.557000													18	87					0	0	0.219247	0	0
KCNN3	3782	broad.mit.edu	37	1	154841844	154841844	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:154841844G>C	ENST00000271915.4	-	1	912	c.597C>G	c.(595-597)atC>atG	p.I199M		NM_001204087.1|NM_002249.5	NP_001191016.1|NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3							integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TCTCGGCCTCGATGAGGTTCC	0.637000													7	61					0	0	0.307466	0	0
CLYBL	171425	broad.mit.edu	37	13	100523272	100523272	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:100523272G>A	ENST00000376355.3	+	6	812	c.781G>A	c.(781-783)Gaa>Aaa	p.E261K	CLYBL_ENST00000376360.1_Missense_Mutation_p.E295K|CLYBL_ENST00000339105.4_Missense_Mutation_p.E295K|CLYBL_ENST00000376354.1_Missense_Mutation_p.E261K|CLYBL_ENST00000444838.2_Missense_Mutation_p.E261K	NM_206808.2	NP_996531.1	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like	295					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding	p.E295*(1)		NS(1)|kidney(6)|large_intestine(6)|lung(10)|skin(2)	25	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TAAGTGGGCTGAAGAACTGAT	0.393000													22	69					0	0	0.279207	0	0
REN	5972	broad.mit.edu	37	1	204135397	204135397	+	Missense_Mutation	SNP	G	G	A	rs115181548	by1000genomes	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:204135397G>A	ENST00000367195.2	-	1	68	c.25C>T	c.(25-27)Cgc>Tgc	p.R9C	REN_ENST00000272190.8_Missense_Mutation_p.R9C			P00797	RENI_HUMAN	renin	9					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AGTCCCCAGCGAGGCATCCTT	0.557000													13	78					0	0	0.132662	0	0
CAPG	822	broad.mit.edu	37	2	85625233	85625233	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85625233C>T	ENST00000263867.4	-	8	1051	c.802G>A	c.(802-804)Gac>Aac	p.D268N	CAPG_ENST00000483659.1_5'UTR|CAPG_ENST00000409921.1_Missense_Mutation_p.D253N|CAPG_ENST00000409670.1_Missense_Mutation_p.D268N|CAPG_ENST00000409724.1_Missense_Mutation_p.D268N	NM_001256140.1|NM_001747.3	NP_001243069.1|NP_001738.2	P40121	CAPG_HUMAN	capping protein (actin filament), gelsolin-like	268					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)	11						GGGCTGGAGTCAGCCACCTTG	0.567000													22	101					0	0	0.323286	0	0
KIF3B	9371	broad.mit.edu	37	20	30897849	30897849	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:30897849G>A	ENST00000375712.3	+	2	436	c.269G>A	c.(268-270)gGa>gAa	p.G90E		NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	90	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGTTTCAATGGAACCATTTTT	0.453000													35	78					0	0	0.279185	0	0
INF2	64423	broad.mit.edu	37	14	105172458	105172458	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:105172458C>G	ENST00000392634.4	+	6	900	c.788C>G	c.(787-789)tCt>tGt	p.S263C	INF2_ENST00000330634.7_Missense_Mutation_p.S263C	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	263	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CTGCGAGTCTCTGGCGGGGTC	0.672000													8	14					0	0	0.335167	0	0
IGDCC4	57722	broad.mit.edu	37	15	65693281	65693281	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:65693281G>A	ENST00000352385.2	-	5	913	c.704C>T	c.(703-705)tCc>tTc	p.S235F		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	235						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						GGACGCCAGGGACCCTGGCGA	0.592000											OREG0023196	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	62					0	0	0.410975	0	0
S1PR3	1903	broad.mit.edu	37	9	91617099	91617099	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:91617099C>T	ENST00000375846.3	+	1	5679	c.984C>T	c.(982-984)atC>atT	p.I328I	S1PR3_ENST00000358157.2_Silent_p.I328I			Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	328					anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(1)	34						CCTCACCCATCCAGCCTGCGC	0.627000													18	27					0	0	0.234183	0	0
MSTN	2660	broad.mit.edu	37	2	190927191	190927191	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190927191C>A	ENST00000260950.4	-	1	264	c.132G>T	c.(130-132)tgG>tgT	p.W44C	C2orf88_ENST00000478197.1_Intron	NM_005259.2	NP_005250.1	O14793	GDF8_HUMAN	myostatin	44					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)	12			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TGTTTTGTCTCCAAGTACATG	0.378000													29	202					5.71845e-15	6.31814e-15	0.225048	1	0
PCDH8	5100	broad.mit.edu	37	13	53419572	53419572	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:53419572G>C	ENST00000377942.3	-	2	3030	c.2827C>G	c.(2827-2829)Cac>Gac	p.H943D	PCDH8_ENST00000338862.4_Missense_Mutation_p.H846D	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	943					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CTCTGCATGTGGTTGATGAGA	0.532000													29	39					0	0	0.173368	0	0
B4GALNT3	283358	broad.mit.edu	37	12	660168	660168	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:660168C>T	ENST00000266383.5	+	11	1091	c.1078C>T	c.(1078-1080)Cct>Tct	p.P360S		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	360						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GGATGGGCTTCCTCTGCAGCG	0.607000													31	69					0	0	0.225048	0	0
CACNA1G	8913	broad.mit.edu	37	17	48655779	48655779	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:48655779G>C	ENST00000352832.5	+	9	2527	c.2155G>C	c.(2155-2157)Gat>Cat	p.D719H	CACNA1G_ENST00000502264.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000442258.2_Missense_Mutation_p.D719H|CACNA1G_ENST00000510115.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000360761.4_Missense_Mutation_p.D719H|CACNA1G_ENST00000507896.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000358244.5_Missense_Mutation_p.D719H|CACNA1G_ENST00000416767.4_Missense_Mutation_p.D719H|CACNA1G_ENST00000510366.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000505165.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000515411.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000514717.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000503485.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000429973.2_Missense_Mutation_p.D719H|CACNA1G_ENST00000514181.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000514079.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000515765.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000513964.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000507609.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000507336.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000515165.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000359106.5_Missense_Mutation_p.D719H|CACNA1G_ENST00000513689.2_Missense_Mutation_p.D719H|CACNA1G_ENST00000512389.1_Missense_Mutation_p.D719H|CACNA1G_ENST00000354983.4_Missense_Mutation_p.D719H|CACNA1G_ENST00000507510.2_Missense_Mutation_p.D719H	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	719					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCTGGGCCCAGATGCAGAGCC	0.602000													17	61					0	0	0.146539	0	0
NTRK3	4916	broad.mit.edu	37	15	88576243	88576243	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:88576243G>C	ENST00000394480.2	-	14	1751	c.1430C>G	c.(1429-1431)tCa>tGa	p.S477*	NTRK3_ENST00000557856.1_Nonsense_Mutation_p.S469*|NTRK3_ENST00000558676.1_Nonsense_Mutation_p.S469*|NTRK3_ENST00000542733.2_Nonsense_Mutation_p.S379*|NTRK3_ENST00000558306.1_5'UTR|NTRK3_ENST00000355254.2_Nonsense_Mutation_p.S477*|NTRK3_ENST00000540489.2_Nonsense_Mutation_p.S477*|NTRK3_ENST00000357724.2_Nonsense_Mutation_p.S469*|NTRK3_ENST00000360948.2_Nonsense_Mutation_p.S477*|NTRK3_ENST00000317501.3_Nonsense_Mutation_p.S477*	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3						transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGGGCTGGCTGAGTCCTCCTC	0.622000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			5	12					0	0	0.184627	0	0
ARID4A	5926	broad.mit.edu	37	14	58831818	58831818	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:58831818C>G	ENST00000355431.3	+	20	3384	c.3011C>G	c.(3010-3012)tCa>tGa	p.S1004*	ARID4A_ENST00000395168.3_Nonsense_Mutation_p.S1004*|ARID4A_ENST00000431317.2_Nonsense_Mutation_p.S1004*|ARID4A_ENST00000348476.3_Nonsense_Mutation_p.S1004*	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	1004					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						CATAACTTTTCAGTAGCTTCA	0.403000													19	170					0	0	0.219247	0	0
CBL	867	broad.mit.edu	37	11	119167741	119167741	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:119167741C>T	ENST00000264033.4	+	13	2526	c.2150C>T	c.(2149-2151)tCa>tTa	p.S717L		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	717	Asp/Glu-rich (acidic).|Interaction with CD2AP.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		TCCCAGAGTTCACGGTAGGTT	0.507000			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies				40	71					0	0	0.323286	0	0
GMPPB	29925	broad.mit.edu	37	3	49759447	49759447	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49759447G>A	ENST00000480687.1	-	9	1018	c.902C>T	c.(901-903)tCc>tTc	p.S301F	GMPPB_ENST00000308388.6_Missense_Mutation_p.S301F|GMPPB_ENST00000308375.6_Missense_Mutation_p.S301F|AMIGO3_ENST00000535833.1_5'UTR			Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B	301					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTCAAGCCAGGAATGGGAACG	0.667000													12	114					0	0	0.175082	0	0
NBPF10	100132406	broad.mit.edu	37	1	145301812	145301812	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:145301812G>A	ENST00000342960.5	+	7	1116	c.1081G>A	c.(1081-1083)Gag>Aag	p.E361K	NBPF10_ENST00000369339.3_Missense_Mutation_p.E90K|NBPF10_ENST00000369338.1_Missense_Mutation_p.E90K|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	361										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CAAGCAAGCTGAGGAGCTCAG	0.522000													13	231					0	0	0.294199	0	0
HEATR6	63897	broad.mit.edu	37	17	58156241	58156241	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:58156241G>A	ENST00000184956.6	-	1	51	c.35C>T	c.(34-36)tCc>tTc	p.S12F	HEATR6_ENST00000585976.1_Missense_Mutation_p.S12F|HEATR6_ENST00000585712.1_5'UTR	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	12							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			CGGCTGCACGGAAGGCCACGA	0.652000													4	26					0	0	0.184627	0	0
NR1D1	9572	broad.mit.edu	37	17	38253600	38253600	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38253600C>G	ENST00000246672.3	-	2	718	c.88G>C	c.(88-90)Gaa>Caa	p.E30Q		NM_021724.3	NP_068370.1	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	30					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|large_intestine(5)|lung(2)|skin(1)|upper_aerodigestive_tract(2)	11	Colorectal(19;0.000442)					TAGAGGGATTCAGGGCTGGTG	0.587000													17	22					0	0	0.219247	0	0
AMIGO3	386724	broad.mit.edu	37	3	49756782	49756782	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49756782G>C	ENST00000535833.1	-	10	3567	c.117C>G	c.(115-117)atC>atG	p.I39M	AMIGO3_ENST00000320431.7_Missense_Mutation_p.I39M|RNF123_ENST00000433785.1_Intron|RNF123_ENST00000327697.6_Intron|RNF123_ENST00000497099.1_Intron|GMPPB_ENST00000480687.1_3'UTR			Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	39	LRRNT.				heterophilic cell-cell adhesion	integral to membrane				endometrium(1)|pancreas(1)|prostate(2)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CGGCAGCGCAGATACATTTGT	0.652000											OREG0015572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	144					0	0	0.279207	0	0
ZNF672	79894	broad.mit.edu	37	1	249142668	249142668	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:249142668G>C	ENST00000306562.3	+	4	1941	c.1195G>C	c.(1195-1197)Gag>Cag	p.E399Q		NM_024836.1	NP_079112.1	Q499Z4	ZN672_HUMAN	zinc finger protein 672	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)	5	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGAGTGCGCAGAGTGCGGCAA	0.682000													6	10					0	0	0.217242	0	0
CHD2	1106	broad.mit.edu	37	15	93558002	93558002	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:93558002C>G	ENST00000394196.4	+	37	5837	c.4769C>G	c.(4768-4770)tCt>tGt	p.S1590C	CHD2_ENST00000557381.1_Missense_Mutation_p.S1590C	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1590					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AGCCGGGACTCTCTGATATCT	0.512000													57	102					0	0	0.323286	0	0
KRT12	3859	broad.mit.edu	37	17	39017933	39017933	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:39017933C>A	ENST00000251643.4	-	8	1488	c.1465G>T	c.(1465-1467)Gaa>Taa	p.E489*	RP5-1110E20.1_ENST00000579136.1_RNA	NM_000223.3	NP_000214.1	Q99456	K1C12_HUMAN	keratin 12	489	Tail.				visual perception	intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	15		Breast(137;0.000301)				TCTTCAATTTCCTGAACTTGA	0.368000													11	65					6.31663e-08	6.65502e-08	0.132662	1	0
ZNF549	256051	broad.mit.edu	37	19	58048854	58048854	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:58048854G>A	ENST00000376233.3	+	4	663	c.482G>A	c.(481-483)aGa>aAa	p.R161K	ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000601415.1_Intron|ZNF549_ENST00000240719.3_Missense_Mutation_p.R148K|ZNF549_ENST00000594943.1_Intron	NM_001199295.1	NP_001186224	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAACACATCAGAAAGGAGGAG	0.453000													22	50					0	0	0.264190	0	0
CELSR3	1951	broad.mit.edu	37	3	48675652	48675652	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48675652C>A	ENST00000544264.1	-	36	10220	c.9940G>T	c.(9940-9942)Gag>Tag	p.E3314*	CELSR3_ENST00000164024.4_Nonsense_Mutation_p.E3309*			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	3309					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAGTGACCCTCACTTCTGGGA	0.607000													21	55					6.00712e-18	6.75086e-18	0.410975	1	0
LRP10	26020	broad.mit.edu	37	14	23342569	23342569	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23342569G>C	ENST00000359591.4	+	3	820	c.129G>C	c.(127-129)caG>caC	p.Q43H	LRP10_ENST00000546834.1_Missense_Mutation_p.Q43H	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	43	CUB 1.				endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		GCACCTTACAGAGGCCCCTGG	0.602000													26	53					0	0	0.324025	0	0
TCHH	7062	broad.mit.edu	37	1	152081239	152081239	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:152081239C>G	ENST00000368804.1	-	2	4453	c.4454G>C	c.(4453-4455)aGa>aCa	p.R1485T		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1485	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGGAATTTTCTGTCACGCTC	0.552000													44	147					0	0	0.323286	0	0
FBXO18	84893	broad.mit.edu	37	10	5945065	5945065	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:5945065C>A	ENST00000379999.5	+	3	341	c.237C>A	c.(235-237)ttC>ttA	p.F79L	FBXO18_ENST00000397269.3_5'UTR|FBXO18_ENST00000470089.1_Intron|FBXO18_ENST00000362091.4_Missense_Mutation_p.F28L	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	28					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						CCCAGCCCTTCGGTCAAAGAT	0.488000													26	40					1.99505e-19	2.27236e-19	0.410975	1	0
TSPEAR	54084	broad.mit.edu	37	21	45948429	45948429	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:45948429C>T	ENST00000323084.4	-	6	893	c.828G>A	c.(826-828)ccG>ccA	p.P276P	TSPEAR_ENST00000397916.1_Silent_p.P208P	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	276					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						CCTCGGTACACGGTGGCTGGG	0.577000													27	25					0	0	0.324025	0	0
MST1R	4486	broad.mit.edu	37	3	49927421	49927421	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49927421C>G	ENST00000296474.3	-	19	3910	c.3883G>C	c.(3883-3885)Gac>Cac	p.D1295H	MST1R_ENST00000344206.4_Missense_Mutation_p.D1246H	NM_002447.2	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	1295	Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TGGGTAAGGTCAAAAGGGTCA	0.602000													35	82					0	0	0.301197	0	0
DAG1	1605	broad.mit.edu	37	3	49568599	49568599	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49568599G>A	ENST00000545947.1	+	6	1377	c.655G>A	c.(655-657)Gaa>Aaa	p.E219K	DAG1_ENST00000539901.1_Missense_Mutation_p.E219K|DAG1_ENST00000538711.1_Missense_Mutation_p.E219K|DAG1_ENST00000541308.1_Missense_Mutation_p.E219K|DAG1_ENST00000515359.2_Missense_Mutation_p.E219K|DAG1_ENST00000308775.2_Missense_Mutation_p.E219K	NM_001177634.2	NP_001171105	Q14118	DAG1_HUMAN	dystroglycan 1 (dystrophin-associated glycoprotein 1)	219	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GAGCTTCTCAGAAGTAGAGCT	0.488000													20	45					0	0	0.279207	0	0
MALAT1	378938	broad.mit.edu	37	11	65272223	65272223	+	RNA	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65272223G>A	ENST00000534336.1	+	0	6991					NR_002819.2																						ACAGTTCAGTGATCTTTAGTG	0.413000													14	60					0	0	0.160694	0	0
HCFC1	3054	broad.mit.edu	37	X	153229678	153229678	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:153229678G>C	ENST00000310441.7	-	3	1366	c.400C>G	c.(400-402)Ccg>Gcg	p.P134A	HCFC1_ENST00000369984.4_Missense_Mutation_p.P134A|HCFC1_ENST00000354233.3_Missense_Mutation_p.P134A	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	134					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGAGGACACGGAGGGGGCCCG	0.562000													56	38					0	0	0.323286	0	0
CDKL1	8814	broad.mit.edu	37	14	50825768	50825768	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:50825768C>T	ENST00000216378.2	-	3	915	c.271G>A	c.(271-273)Gag>Aag	p.E91K	CDKL1_ENST00000395834.1_Missense_Mutation_p.E91K|CDKL1_ENST00000356146.1_5'UTR	NM_001282236.1	NP_001269165.1	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1 (CDC2-related kinase)	90	Protein kinase.					cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|stomach(1)	12	all_epithelial(31;0.000746)|Breast(41;0.0102)					CTGTCCAACTCATGGAGAACT	0.453000													50	145					0	0	0.323286	0	0
EIF5B	9669	broad.mit.edu	37	2	100007070	100007070	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:100007070G>C	ENST00000289371.6	+	17	2852	c.2650G>C	c.(2650-2652)Gaa>Caa	p.E884Q		NM_015904.3	NP_056988.3	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B						regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GCGTTTGAAGGAAGGAGATAC	0.448000													33	105					0	0	0.257332	0	0
SERPINH1	871	broad.mit.edu	37	11	75282943	75282943	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:75282943G>C	ENST00000524558.1	+	5	2507	c.1072G>C	c.(1072-1074)Gag>Cag	p.E358Q	SERPINH1_ENST00000358171.3_Missense_Mutation_p.E358Q|SERPINH1_ENST00000525876.1_Missense_Mutation_p.E141Q|SERPINH1_ENST00000533603.1_Missense_Mutation_p.E358Q			P50454	SERPH_HUMAN	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	358					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			endometrium(4)|large_intestine(3)|liver(1)|lung(4)|ovary(2)|stomach(1)	15	Ovarian(111;0.11)					CACCGCCTTTGAGTTGGACAC	0.597000													17	27					0	0	0.249174	0	0
DNAJC16	23341	broad.mit.edu	37	1	15892682	15892682	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:15892682C>G	ENST00000375838.1	+	13	1949	c.1785C>G	c.(1783-1785)ctC>ctG	p.L595L	DNAJC16_ENST00000375849.1_Intron|DNAJC16_ENST00000483270.1_3'UTR|DNAJC16_ENST00000375847.3_Intron			Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	0					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GCAGGTTTCTCTAACAAAACA	0.493000													3	22					0	0	0.115264	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21392046	21392046	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:21392046G>A	ENST00000256958.2	+	15	2095	c.1999G>A	c.(1999-2001)Gaa>Aaa	p.E667K		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	667			E -> G (in dbSNP:rs55737008).		bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TGTCATGGATGAAGCAAACTT	0.318000													8	28					0	0	0.278610	0	0
BRAT1	221927	broad.mit.edu	37	7	2579517	2579517	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:2579517C>G	ENST00000340611.4	-	11	1657	c.1401G>C	c.(1399-1401)ctG>ctC	p.L467L	BRAT1_ENST00000473879.1_5'UTR	NM_152743.3	NP_689956.2	Q6PJG6	BRAT1_HUMAN	BRCA1-associated ATM activator 1	467					response to ionizing radiation	nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23						AGGCCTTCTTCAGAACCTGGA	0.652000													4	5					0	0	0.217242	0	0
RGAG1	57529	broad.mit.edu	37	X	109695851	109695851	+	Missense_Mutation	SNP	C	C	T	rs148619359		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:109695851C>T	ENST00000465301.2	+	3	2252	c.2006C>T	c.(2005-2007)tCg>tTg	p.S669L	RGAG1_ENST00000540313.1_Missense_Mutation_p.S669L	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	669										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						TTGTCTGCATCGCTAATGAGA	0.512000													13	32					0	0	0.119110	0	0
CD28	940	broad.mit.edu	37	2	204571328	204571328	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:204571328C>G	ENST00000458610.2	+	1	82	c.82C>G	c.(82-84)Cag>Gag	p.Q28E	CD28_ENST00000374481.3_5'UTR|CD28_ENST00000324106.8_5'UTR			P10747	CD28_HUMAN	CD28 molecule	14	Ig-like V-type.				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13						CGGAGACTCTCAGGCCTTGGC	0.592000													4	23					0	0	0.150653	0	0
SF3B2	10992	broad.mit.edu	37	11	65824372	65824372	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65824372C>T	ENST00000528302.1	+	5	616	c.562C>T	c.(562-564)Cgg>Tgg	p.R188W	SF3B2_ENST00000322535.6_Missense_Mutation_p.R205W			Q13435	SF3B2_HUMAN	splicing factor 3b, subunit 2, 145kDa	205					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	41						CCCAGTCCCTCGGCCCCCACA	0.587000													17	66					0	0	0.234183	0	0
PALD1	27143	broad.mit.edu	37	10	72324122	72324122	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:72324122G>A	ENST00000263563.6	+	19	2533	c.2265G>A	c.(2263-2265)gcG>gcA	p.A755A		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		TCCTCCAGGCGAAGGCAGCGA	0.617000													30	56					0	0	0.214465	0	0
GNB1L	54584	broad.mit.edu	37	22	19808787	19808787	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:19808787C>G	ENST00000329517.6	-	3	328	c.92G>C	c.(91-93)gGa>gCa	p.G31A	GNB1L_ENST00000403325.1_Missense_Mutation_p.G31A|GNB1L_ENST00000460402.1_Intron|GNB1L_ENST00000405009.1_Missense_Mutation_p.G31A	NM_053004.2	NP_443730.1	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 1-like	31					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	12	Colorectal(54;0.0993)					AGCCTGGGCTCCTTCGCAGAA	0.687000													18	71					0	0	0.204396	0	0
COL17A1	1308	broad.mit.edu	37	10	105819447	105819447	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:105819447C>G	ENST00000353479.5	-	15	1461	c.1171G>C	c.(1171-1173)Gaa>Caa	p.E391Q	COL17A1_ENST00000393211.3_Missense_Mutation_p.E391Q|COL17A1_ENST00000369733.3_Missense_Mutation_p.E391Q	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	391	Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GCTTGCTTTTCTTTTTTTAGG	0.438000													19	38					0	0	0.249174	0	0
GDPD4	220032	broad.mit.edu	37	11	76980082	76980082	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:76980082G>A	ENST00000315938.4	-	8	761	c.511C>T	c.(511-513)Ctt>Ttt	p.L171F	GDPD4_ENST00000376217.2_Missense_Mutation_p.L171F	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	171					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						AAAAGGATAAGAAGAAAGGGT	0.438000													7	38					0	0	0.278610	0	0
KMT2C	58508	broad.mit.edu	37	7	151945439	151945439	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:151945439G>A	ENST00000355193.2	-	14	2298	c.2080C>T	c.(2080-2082)Ctt>Ttt	p.L694F	KMT2C_ENST00000262189.6_Missense_Mutation_p.L694F					lysine (K)-specific methyltransferase 2C																		TCTAGTGGAAGAGTGACAGAT	0.423000													5	40					0	0	0.184627	0	0
WDR36	134430	broad.mit.edu	37	5	110428137	110428137	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:110428137G>C	ENST00000506538.2	+	1	724	c.151G>C	c.(151-153)Gct>Cct	p.A51P	WDR36_ENST00000513710.2_Missense_Mutation_p.A51P|WDR36_ENST00000505303.1_5'UTR	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	51					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		GCTGAGAGGAGCTGGGATCGC	0.602000													7	48					0	0	0.361761	0	0
HAUS5	23354	broad.mit.edu	37	19	36108218	36108218	+	Silent	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:36108218G>T	ENST00000203166.5	+	8	610	c.585G>T	c.(583-585)cgG>cgT	p.R195R	HAUS5_ENST00000379045.2_Silent_p.R195R	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	195					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						GCACCCTCCGGGCCCAGTTCC	0.632000													35	52					2.64894e-19	3.01132e-19	0.323286	1	0
ADCY1	107	broad.mit.edu	37	7	45743204	45743204	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:45743204C>G	ENST00000297323.7	+	16	2599	c.2577C>G	c.(2575-2577)ctC>ctG	p.L859L		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	859					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	TCCAGGACCTCTACTACCAGT	0.582000													24	70					0	0	0.294199	0	0
MSTN	2660	broad.mit.edu	37	2	190925004	190925004	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190925004G>C	ENST00000260950.4	-	2	663	c.531C>G	c.(529-531)atC>atG	p.I177M	C2orf88_ENST00000478197.1_Intron	NM_005259.2	NP_005250.1	O14793	GDF8_HUMAN	myostatin	177					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)	12			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TCATAGGTTTGATGAGTCTCA	0.413000													11	228					0	0	0.093190	0	0
SLC24A2	25769	broad.mit.edu	37	9	19521029	19521029	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:19521029C>G	ENST00000341998.2	-	9	1660	c.1599G>C	c.(1597-1599)gaG>gaC	p.E533D	SLC24A2_ENST00000286344.3_Missense_Mutation_p.E516D	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	533					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GGCCCATAATCTCTTCACTGA	0.448000													14	17					0	0	0.189662	0	0
MPHOSPH8	54737	broad.mit.edu	37	13	20242605	20242605	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:20242605C>G	ENST00000361479.5	+	11	2331	c.2263C>G	c.(2263-2265)Cga>Gga	p.R755G	MPHOSPH8_ENST00000414242.2_Missense_Mutation_p.R755G	NM_017520.3	NP_059990.2	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	755					cell cycle	cytoplasm|nucleus				breast(2)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		CGCATGTCATCGACTCTGTGA	0.413000													10	32					0	0	0.335167	0	0
EFHB	151651	broad.mit.edu	37	3	19925987	19925987	+	Missense_Mutation	SNP	C	C	T	rs142916632	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:19925987C>T	ENST00000295824.9	-	11	2215	c.2054G>A	c.(2053-2055)cGg>cAg	p.R685Q	EFHB_ENST00000344838.4_Missense_Mutation_p.R555Q	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	685				R -> W (in Ref. 1; BAC85491).	signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						CAGAAGTGTCCGGAGAGTCTT	0.398000													13	32					0	0	0.146539	0	0
PLEC	5339	broad.mit.edu	37	8	144999683	144999683	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:144999683C>T	ENST00000322810.4	-	31	4994	c.4825G>A	c.(4825-4827)Gag>Aag	p.E1609K	PLEC_ENST00000436759.2_Missense_Mutation_p.E1499K|PLEC_ENST00000345136.3_Missense_Mutation_p.E1472K|PLEC_ENST00000398774.2_Missense_Mutation_p.E1440K|PLEC_ENST00000357649.2_Missense_Mutation_p.E1476K|PLEC_ENST00000354958.2_Missense_Mutation_p.E1450K|PLEC_ENST00000527096.1_Missense_Mutation_p.E1495K|PLEC_ENST00000356346.3_Missense_Mutation_p.E1458K|PLEC_ENST00000354589.3_Missense_Mutation_p.E1472K	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1609	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						AGCTCCCCCTCAGCCCCGCCA	0.721000													5	25					0	0	0.217242	0	0
NAV3	89795	broad.mit.edu	37	12	78400995	78400995	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:78400995G>A	ENST00000397909.2	+	8	1850	c.1677G>A	c.(1675-1677)ggG>ggA	p.G559G	NAV3_ENST00000228327.6_Silent_p.G559G|NAV3_ENST00000536525.2_Silent_p.G559G|NAV3_ENST00000266692.7_Silent_p.G559G			Q8IVL0	NAV3_HUMAN	neuron navigator 3	559						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CTACCAAGGGGAGCCCTTCCC	0.483000										HNSCC(70;0.22)			19	46					0	0	0.249174	0	0
PPAP2A	8611	broad.mit.edu	37	5	54737722	54737722	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:54737722G>C	ENST00000307259.8	-	4	926	c.506C>G	c.(505-507)tCa>tGa	p.S169*	PPAP2A_ENST00000264775.5_Nonsense_Mutation_p.S170*	NM_003711.2	NP_003702.2	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A	169					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	9		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				AGAGTGGCCTGAATAGAAGGA	0.393000													26	45					0	0	0.368089	0	0
TTC3	7267	broad.mit.edu	37	21	38463619	38463619	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:38463619G>C	ENST00000399017.2	+	7	3254	c.507G>C	c.(505-507)ctG>ctC	p.L169L	TTC3_ENST00000354749.2_Silent_p.L169L|TTC3_ENST00000540756.1_Intron|TTC3_ENST00000399010.1_Silent_p.L169L|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000355666.1_Silent_p.L169L	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	169					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				AAGAAGCTCTGAATTGGATAA	0.308000													11	68					0	0	0.119110	0	0
SLC23A3	151295	broad.mit.edu	37	2	220033453	220033453	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:220033453G>A	ENST00000455516.2	-	5	666	c.619C>T	c.(619-621)Ccc>Tcc	p.P207S	SLC23A3_ENST00000396775.3_Intron|SLC23A3_ENST00000295738.7_Missense_Mutation_p.P199S|SLC23A3_ENST00000409878.3_Missense_Mutation_p.P199S	NM_001144890.1	NP_001138362.1	Q6PIS1	S23A3_HUMAN	solute carrier family 23, member 3	199					transmembrane transport	integral to membrane	protein binding|transporter activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	11		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACCAGGCTGGGAGCCAGCACC	0.662000													4	15					0	0	0.184627	0	0
USP4	7375	broad.mit.edu	37	3	49362462	49362462	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49362462C>A	ENST00000351842.4	-	5	506	c.498G>T	c.(496-498)gaG>gaT	p.E166D	USP4_ENST00000415188.1_Missense_Mutation_p.E166D|USP4_ENST00000416417.1_Missense_Mutation_p.E166D|USP4_ENST00000265560.4_Missense_Mutation_p.E166D	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	166					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GCATCTCTTTCTCGATGGTTG	0.478000													21	131					3.73808e-20	4.28246e-20	0.324025	1	0
FIGF	2277	broad.mit.edu	37	X	15371214	15371214	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:15371214C>T	ENST00000297904.3	-	5	1147	c.718G>A	c.(718-720)Gaa>Aaa	p.E240K		NM_004469.4	NP_004460.1	O43915	VEGFD_HUMAN	c-fos induced growth factor (vascular endothelial growth factor D)	240	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	17	Hepatocellular(33;0.183)					AGTGGATTTTCCTCCTGCAAA	0.353000													14	35					0	0	0.204396	0	0
EIF5B	9669	broad.mit.edu	37	2	100006708	100006708	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:100006708G>C	ENST00000289371.6	+	16	2632	c.2430G>C	c.(2428-2430)gaG>gaC	p.E810D		NM_015904.3	NP_056988.3	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B						regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TGTTTTATGAGAATAAAGATC	0.428000													70	178					0	0	0.323286	0	0
TRIP11	9321	broad.mit.edu	37	14	92471718	92471718	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:92471718C>G	ENST00000267622.4	-	11	2975	c.2602G>C	c.(2602-2604)Gaa>Caa	p.E868Q		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	868					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		CGTTCCAATTCTTCTTGCAGA	0.418000			T	PDGFRB	AML								24	68					0	0	0.309145	0	0
ARAP1	116985	broad.mit.edu	37	11	72437906	72437906	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:72437906G>A	ENST00000359373.5	-	3	1119	c.268C>T	c.(268-270)Cgc>Tgc	p.R90C	ARAP1_ENST00000393609.3_Missense_Mutation_p.R90C|ARAP1_ENST00000455638.2_Missense_Mutation_p.R90C			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	90					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						GGTGGTGAGCGGAAGATGTGG	0.726000													3	14					0	0	0.150653	0	0
HRC	3270	broad.mit.edu	37	19	49658154	49658154	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:49658154C>T	ENST00000252825.4	-	1	527	c.341G>A	c.(340-342)gGa>gAa	p.G114E	HRC_ENST00000595625.1_Missense_Mutation_p.G114E	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	114	4 X tandem repeats, acidic.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		ACCCTCATCTCCGACTTTGTG	0.577000													7	73					0	0	0.307466	0	0
DIEXF	27042	broad.mit.edu	37	1	210014333	210014333	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:210014333C>G	ENST00000491415.2	+	8	1475	c.1418C>G	c.(1417-1419)tCt>tGt	p.S473C		NM_014388.6	NP_055203.4	Q68CQ4	DIEXF_HUMAN	digestive organ expansion factor homolog (zebrafish)	473					multicellular organismal development	nucleus				breast(6)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(15)|large_intestine(7)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(2)	53						GACTTTCTGTCTTCTATCGAG	0.483000													24	96					0	0	0.309145	0	0
TNRC6B	23112	broad.mit.edu	37	22	40662821	40662821	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:40662821C>T	ENST00000454349.2	+	5	2798	c.2587C>T	c.(2587-2589)Cag>Tag	p.Q863*	TNRC6B_ENST00000402203.1_Intron|TNRC6B_ENST00000301923.9_Intron|TNRC6B_ENST00000335727.9_Nonsense_Mutation_p.Q863*	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	863	Pro-rich.				gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						CAGCGGGCCACAGCCTGCAAC	0.582000													6	23					0	0	0.248553	0	0
ITGA4	3676	broad.mit.edu	37	2	182363467	182363467	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:182363467G>C	ENST00000397033.2	+	15	2088	c.1658G>C	c.(1657-1659)aGa>aCa	p.R553T		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	553					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GTGTCCAGCAGAGAAGCTAAC	0.383000													18	79					0	0	0.264190	0	0
SLC9A2	6549	broad.mit.edu	37	2	103322367	103322367	+	Silent	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:103322367A>G	ENST00000233969.2	+	11	2182	c.2040A>G	c.(2038-2040)ctA>ctG	p.L680L		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	680						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						CAGAAAAGCTACAAAAGAGGA	0.303000													13	30					0	0	0.132662	0	0
SYNE2	23224	broad.mit.edu	37	14	64518876	64518876	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:64518876G>A	ENST00000358025.3	+	48	8475	c.8245G>A	c.(8245-8247)Gaa>Aaa	p.E2749K	SYNE2_ENST00000344113.4_Missense_Mutation_p.E2749K|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000554584.1_Missense_Mutation_p.E2782K	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2749					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTTGTTGGGTGAACTTAATCC	0.413000													61	199					0	0	0.323286	0	0
RBP3	5949	broad.mit.edu	37	10	48389845	48389845	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:48389845C>T	ENST00000224600.4	-	1	1146	c.1033G>A	c.(1033-1035)Gac>Aac	p.D345N		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	345	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GGCACACGGTCCACCAGCGTG	0.637000													11	53					0	0	0.387290	0	0
PIWIL4	143689	broad.mit.edu	37	11	94316613	94316613	+	Splice_Site	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:94316613G>A	ENST00000299001.6	+	5	724		c.e5-1		RP11-867G2.8_ENST00000536540.1_RNA|RP11-867G2.8_ENST00000537874.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4						cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CTTTTTCCCAGGTCACAGAGT	0.418000													71	165					0	0	0.323286	0	0
FANCA	2175	broad.mit.edu	37	16	89807249	89807249	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:89807249G>T	ENST00000389301.3	-	38	3821	c.3791C>A	c.(3790-3792)tCc>tAc	p.S1264Y	FANCA_ENST00000568369.1_Missense_Mutation_p.S1264Y|ZNF276_ENST00000289816.5_3'UTR	NM_000135.2	NP_000126.2	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A	1264					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			breast(5)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|urinary_tract(3)	47		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GCCCATCAAGGAGAAGAAGAA	0.453000			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				18	22					1.2644e-06	1.32269e-06	0.219247	1	0
CXorf23	256643	broad.mit.edu	37	X	19973576	19973576	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:19973576C>G	ENST00000379687.3	-	4	1416	c.1383G>C	c.(1381-1383)caG>caC	p.Q461H	CXorf23_ENST00000356980.3_Missense_Mutation_p.Q461H|CXorf23_ENST00000379682.4_Missense_Mutation_p.Q461H	NM_198279.3	NP_938020.2	A2AJT9	CX023_HUMAN	chromosome X open reading frame 23	461						mitochondrion				endometrium(2)|large_intestine(1)|lung(6)|skin(1)|urinary_tract(1)	11						TTTCAGTATTCTGAGTTGAGT	0.378000													12	29					0	0	0.132662	0	0
KRTAP12-4	386684	broad.mit.edu	37	21	46074247	46074247	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:46074247G>C	ENST00000391618.1	-	1	329	c.285C>G	c.(283-285)ttC>ttG	p.F95L	TSPEAR_ENST00000323084.4_Intron	NM_198698.1	NP_941971.1	P60329	KR124_HUMAN	keratin associated protein 12-4	95	15 X 5 AA approximate repeats.					keratin filament				lung(4)|ovary(1)|prostate(1)	6						GGGTGGGGCAGAAGGGCTGGC	0.632000													6	31					0	0	0.217242	0	0
BBS9	27241	broad.mit.edu	37	7	33185904	33185904	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:33185904C>G	ENST00000242067.6	+	2	561	c.40C>G	c.(40-42)Ctg>Gtg	p.L14V	BBS9_ENST00000354265.4_Missense_Mutation_p.L14V|BBS9_ENST00000396127.2_Missense_Mutation_p.L14V|BBS9_ENST00000355070.2_Missense_Mutation_p.L14V|BBS9_ENST00000482941.1_3'UTR|BBS9_ENST00000350941.3_Missense_Mutation_p.L14V|BBS9_ENST00000425508.2_5'UTR	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	14					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			GTCTACTATTCTGGGAGATAA	0.333000									Bardet-Biedl syndrome				36	100					0	0	0.279185	0	0
TBXAS1	6916	broad.mit.edu	37	7	139706905	139706905	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:139706905C>G	ENST00000263552.6	+	14	1690	c.1152C>G	c.(1150-1152)ttC>ttG	p.F384L	TBXAS1_ENST00000436047.2_Missense_Mutation_p.F384L|TBXAS1_ENST00000411653.1_Missense_Mutation_p.F383L|TBXAS1_ENST00000425687.1_Missense_Mutation_p.F316L|TBXAS1_ENST00000416849.2_Missense_Mutation_p.F430L|TBXAS1_ENST00000336425.5_Missense_Mutation_p.F383L|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000414508.2_Missense_Mutation_p.F384L|TBXAS1_ENST00000448866.1_Missense_Mutation_p.F383L|TBXAS1_ENST00000458722.1_Missense_Mutation_p.F429L	NM_001130966.2	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	383					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					CCCCTGAGTTCTGCAGCCTCG	0.532000													60	133					0	0	0.323286	0	0
IGHV1OR15-9	390531	broad.mit.edu	37	15	20170120	20170120	+	RNA	SNP	T	T	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:20170120T>C	ENST00000338912.5	-	0	151																											GTGCATACAGTAGCTGGTGAA	0.567000													20	65					0	0	0.204396	0	0
KRT76	51350	broad.mit.edu	37	12	53165706	53165706	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:53165706G>C	ENST00000332411.2	-	6	1265	c.1212C>G	c.(1210-1212)ctC>ctG	p.L404L		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	404	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TCATCCTGTTGAGCTCCATGA	0.547000													44	91					0	0	0.323286	0	0
RICTOR	253260	broad.mit.edu	37	5	38952313	38952313	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:38952313C>A	ENST00000357387.3	-	30	3142	c.3112G>T	c.(3112-3114)Gaa>Taa	p.E1038*	RICTOR_ENST00000296782.5_Nonsense_Mutation_p.E1038*	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1038	Ser-rich.				actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					GGCACAGATTCACTTTCACTA	0.343000													21	23					1.1804e-14	1.29932e-14	0.294199	1	0
RFWD3	55159	broad.mit.edu	37	16	74685877	74685877	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:74685877G>A	ENST00000361070.4	-	3	759	c.662C>T	c.(661-663)tCt>tTt	p.S221F	RFWD3_ENST00000571750.1_Missense_Mutation_p.S221F	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	221				S -> P (in Ref. 1; BAF83889).	DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						ATACTCTGCAGAGCTGTCACT	0.468000													82	53					0	0	0.323286	0	0
SRBD1	55133	broad.mit.edu	37	2	45801777	45801777	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:45801777G>A	ENST00000263736.4	-	8	1220	c.1158C>T	c.(1156-1158)ttC>ttT	p.F386F		NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	386					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			AGTTCCGAATGAAGTCAAGCG	0.388000													40	82					0	0	0.323286	0	0
ZNF567	163081	broad.mit.edu	37	19	37211086	37211086	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:37211086G>C	ENST00000585696.1	+	3	2597	c.1367G>C	c.(1366-1368)aGa>aCa	p.R456T	ZNF567_ENST00000536254.2_Missense_Mutation_p.R487T|ZNF567_ENST00000360729.4_Missense_Mutation_p.R456T|ZNF567_ENST00000392163.2_Missense_Mutation_p.R456T|ZNF567_ENST00000588311.1_Missense_Mutation_p.R456T|ZNF850_ENST00000589390.1_Intron			Q8N184	ZN567_HUMAN	zinc finger protein 567	487					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AAGGCCTTTAGAATGAAGTCA	0.418000													22	69					0	0	0.324025	0	0
GLG1	2734	broad.mit.edu	37	16	74511362	74511362	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:74511362G>C	ENST00000422840.2	-	12	1896	c.1897C>G	c.(1897-1899)Cct>Gct	p.P633A	GLG1_ENST00000205061.5_Missense_Mutation_p.P633A|GLG1_ENST00000447066.2_Missense_Mutation_p.P622A	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1	633						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						TGGAGGGCAGGATCCAGCTTG	0.483000													84	58					0	0	0.323286	0	0
EED	8726	broad.mit.edu	37	11	85961447	85961447	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:85961447C>G	ENST00000263360.6	+	2	910	c.224C>G	c.(223-225)tCa>tGa	p.S75*	EED_ENST00000351625.6_Nonsense_Mutation_p.S75*|EED_ENST00000528180.1_Nonsense_Mutation_p.S75*|EED_ENST00000327320.4_Nonsense_Mutation_p.S75*	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	75					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				AAATGGAAGTCAAAGAAATGC	0.388000													31	72					0	0	0.173368	0	0
USP4	7375	broad.mit.edu	37	3	49362149	49362149	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49362149C>G	ENST00000351842.4	-	6	689	c.681G>C	c.(679-681)caG>caC	p.Q227H	USP4_ENST00000415188.1_Missense_Mutation_p.Q227H|USP4_ENST00000416417.1_Missense_Mutation_p.Q227H|USP4_ENST00000265560.4_Missense_Mutation_p.Q227H	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	227					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		ACTGCAAGGTCTGCCTGGGCC	0.438000													13	90					0	0	0.146539	0	0
EIF4E3	317649	broad.mit.edu	37	3	71743081	71743081	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:71743081C>G	ENST00000425534.3	-	5	424	c.417G>C	c.(415-417)tgG>tgC	p.W139C	EIF4E3_ENST00000448225.1_Missense_Mutation_p.W33C|EIF4E3_ENST00000421769.2_Missense_Mutation_p.W33C|EIF4E3_ENST00000295612.3_Missense_Mutation_p.W33C|EIF4E3_ENST00000389826.3_Missense_Mutation_p.W33C|EIF4E3_ENST00000468147.1_5'UTR	NM_001134651.1	NP_001128123.1	Q8N5X7	IF4E3_HUMAN	eukaryotic translation initiation factor 4E family member 3						regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity			large_intestine(1)|lung(3)	4		Prostate(10;0.0166)		BRCA - Breast invasive adenocarcinoma(55;2.56e-05)|Epithelial(33;2.9e-05)|Lung(16;9.28e-05)|LUSC - Lung squamous cell carcinoma(21;0.00227)		GCAACTCTTTCCAAACTGTGG	0.448000													3	10					0	0	0.150653	0	0
PUF60	22827	broad.mit.edu	37	8	144899273	144899273	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:144899273G>A	ENST00000526683.1	-	11	1742	c.1187C>T	c.(1186-1188)tCg>tTg	p.S396L	PUF60_ENST00000313352.7_Missense_Mutation_p.S336L|PUF60_ENST00000453551.2_Missense_Mutation_p.S353L|PUF60_ENST00000524570.1_5'UTR|PUF60_ENST00000349157.6_Missense_Mutation_p.S379L|PUF60_ENST00000527197.1_Missense_Mutation_p.S350L|PUF60_ENST00000456095.2_Missense_Mutation_p.S367L	NM_001271098.1|NM_078480.2	NP_001258027.1|NP_510965.1	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa	396	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding			NS(1)|endometrium(1)|kidney(3)|lung(7)|prostate(2)	14	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CACTCCCACCGAGGGGATGGT	0.612000													5	32					0	0	0.278610	0	0
SOD1	6647	broad.mit.edu	37	21	33036175	33036175	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:33036175C>G	ENST00000270142.6	+	2	293	c.145C>G	c.(145-147)Cat>Gat	p.H49D	SOD1_ENST00000470944.1_3'UTR|SOD1_ENST00000389995.4_Missense_Mutation_p.H30D	NM_000454.4	NP_000445.1	P00441	SODC_HUMAN	superoxide dismutase 1, soluble	49			H -> Q (in ALS1).|H -> R (in ALS1).		activation of MAPK activity|auditory receptor cell stereocilium organization|cell aging|cellular iron ion homeostasis|DNA fragmentation involved in apoptotic nuclear change|double-strand break repair|embryo implantation|glutathione metabolic process|heart contraction|hydrogen peroxide biosynthetic process|locomotory behavior|muscle cell homeostasis|myeloid cell homeostasis|negative regulation of cholesterol biosynthetic process|negative regulation of neuron apoptosis|neurofilament cytoskeleton organization|ovarian follicle development|peripheral nervous system myelin maintenance|placenta development|platelet activation|platelet degranulation|positive regulation of cytokine production|regulation of blood pressure|regulation of mitochondrial membrane potential|regulation of multicellular organism growth|regulation of organ growth|regulation of T cell differentiation in thymus|relaxation of vascular smooth muscle|removal of superoxide radicals|response to axon injury|response to drug|response to ethanol|response to heat|response to hydrogen peroxide|retina homeostasis|sensory perception of sound|spermatogenesis|thymus development	cytoplasmic vesicle|cytosol|dendrite cytoplasm|extracellular matrix|extracellular space|mitochondrial matrix|neuronal cell body|nucleus|peroxisome|protein complex	chaperone binding|copper ion binding|protein homodimerization activity|protein phosphatase 2B binding|superoxide dismutase activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)	4						ATTCCATGTTCATGAGTTTGG	0.448000													37	140					0	0	0.323286	0	0
SALL2	6297	broad.mit.edu	37	14	21991095	21991095	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:21991095G>A	ENST00000327430.3	-	2	3061	c.2767C>T	c.(2767-2769)Cag>Tag	p.Q923*	SALL2_ENST00000317492.5_Intron|SALL2_ENST00000450879.2_Nonsense_Mutation_p.Q786*|SALL2_ENST00000538754.1_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	923							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		AGAGCTGCCTGGGAGGGAAAG	0.597000													27	68					0	0	0.338820	0	0
CETN2	1069	broad.mit.edu	37	X	151996453	151996453	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:151996453G>A	ENST00000370277.3	-	5	517	c.451C>T	c.(451-453)Cga>Tga	p.R151*	CETN2_ENST00000493482.1_5'UTR	NM_004344.1	NP_004335.1	P41208	CETN2_HUMAN	centrin, EF-hand protein, 2	151	EF-hand 4.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(1)|lung(4)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCATCTCGATCAGCTTCA	0.363000								Direct reversal of damage;Nucleotide excision repair (NER)					22	74					0	0	0.353513	0	0
TMEM255A	55026	broad.mit.edu	37	X	119402108	119402108	+	Silent	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:119402108A>G	ENST00000371369.4	-	8	1036	c.810T>C	c.(808-810)taT>taC	p.Y270Y	TMEM255A_ENST00000440464.1_Silent_p.Y186Y|TMEM255A_ENST00000371352.1_Silent_p.Y130Y|TMEM255A_ENST00000309720.5_Silent_p.Y294Y	NM_001104544.1	NP_001098014.1			transmembrane protein 255A																		CCTGAAAGTCATAAGCAGAAT	0.413000													75	45					0	0	0.323286	0	0
ZNF394	84124	broad.mit.edu	37	7	99091818	99091818	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:99091818G>T	ENST00000337673.6	-	3	1223	c.1020C>A	c.(1018-1020)ttC>ttA	p.F340L	ZNF789_ENST00000494186.1_Intron|ZNF394_ENST00000426306.2_3'UTR|ZNF789_ENST00000493485.1_Intron	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	340					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGGAATGATGGAAACTGTCTC	0.483000													31	88					9.78485e-24	1.13197e-23	0.173368	1	0
ATP12A	479	broad.mit.edu	37	13	25280593	25280593	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:25280593C>A	ENST00000218548.6	+	15	2512	c.2179C>A	c.(2179-2181)Cag>Aag	p.Q727K	ATP12A_ENST00000381946.3_Missense_Mutation_p.Q721K	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	721				DAVV -> VGGQ (in Ref. 7; CAA49478).	ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GGAGGGCTGTCAGAGGCAGGT	0.567000													18	29					7.87624e-14	8.57377e-14	0.264190	1	0
KDM1A	23028	broad.mit.edu	37	1	23395118	23395118	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:23395118C>T	ENST00000400181.4	+	11	1370	c.1266C>T	c.(1264-1266)ttC>ttT	p.F422F	KDM1A_ENST00000356634.3_Silent_p.F398F|RP1-184J9.2_ENST00000427154.1_RNA|KDM1A_ENST00000542151.1_Silent_p.F422F	NM_001009999.2	NP_001009999.1	O60341	KDM1A_HUMAN	lysine (K)-specific demethylase 1A	398	Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(2)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						AACTAGACTTCAATGTCCTCA	0.398000													18	28					0	0	0.189662	0	0
UTP20	27340	broad.mit.edu	37	12	101767377	101767377	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:101767377G>C	ENST00000261637.4	+	54	7137	c.6963G>C	c.(6961-6963)gaG>gaC	p.E2321D		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	2321					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						TGCTCCATGAGAACTGCGGAA	0.478000													15	25					0	0	0.189662	0	0
GLYATL1	92292	broad.mit.edu	37	11	58711103	58711103	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:58711103G>A	ENST00000300079.5	+	2	162	c.112G>A	c.(112-114)Gtg>Atg	p.V38M	GLYATL1_ENST00000317391.4_5'UTR|RP11-142C4.6_ENST00000533954.1_RNA	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	0						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	ggatccaattgtgtccattga	0.478000													9	56					0	0	0.387290	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18650568	18650568	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:18650568C>T	ENST00000433979.1	+	21	2895	c.2779C>T	c.(2779-2781)Cgt>Tgt	p.R927C	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.R927C|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.R968C	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	927	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				AGATGATCTTCGTCAGGATAT	0.363000													8	41					0	0	0.093190	0	0
KIFAP3	22920	broad.mit.edu	37	1	169930298	169930298	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:169930298C>G	ENST00000367765.1	-	18	3443	c.1942G>C	c.(1942-1944)Gag>Cag	p.E648Q	KIFAP3_ENST00000540905.1_Missense_Mutation_p.E390Q|KIFAP3_ENST00000361580.2_Missense_Mutation_p.E688Q|KIFAP3_ENST00000367767.1_Missense_Mutation_p.E644Q|KIFAP3_ENST00000538366.1_Missense_Mutation_p.E610Q	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	688					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding	p.E688K(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGACGACTCTCTACCATCTCC	0.408000													63	83					0	0	0.323286	0	0
RNF219	79596	broad.mit.edu	37	13	79190193	79190193	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:79190193G>C	ENST00000282003.6	-	6	1761	c.1703C>G	c.(1702-1704)tCa>tGa	p.S568*	RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000606429.1_RNA	NM_024546.3	NP_078822.3	Q5W0B1	RN219_HUMAN	ring finger protein 219	568	Ser-rich.						zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|liver(1)|lung(11)|prostate(1)|skin(1)	32		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		AGATGACTTTGATAACCCATC	0.383000													63	133					0	0	0.323286	0	0
H3F3B	3021	broad.mit.edu	37	17	73775024	73775024	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:73775024C>A	ENST00000254810.4	-	3	281	c.149G>T	c.(148-150)cGa>cTa	p.R50L	H3F3B_ENST00000587560.1_Missense_Mutation_p.R50L|H3F3B_ENST00000589599.1_Missense_Mutation_p.R50L|H3F3B_ENST00000591890.1_Missense_Mutation_p.R50L|H3F3B_ENST00000592643.1_Missense_Mutation_p.R50L|H3F3B_ENST00000593254.1_Intron|H3F3B_ENST00000586607.1_Missense_Mutation_p.R50L	NM_005324.3	NP_005315.1	P84243	H33_HUMAN	H3 histone, family 3B (H3.3B)	50					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			large_intestine(1)|lung(4)|ovary(2)|skin(1)	8	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACGAATCTCTCGAAGCGCCAC	0.652000											OREG0024740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	60					9.70103e-10	1.03501e-09	0.361761	1	0
PEX1	5189	broad.mit.edu	37	7	92143172	92143172	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:92143172C>G	ENST00000248633.4	-	6	1444	c.1349G>C	c.(1348-1350)aGa>aCa	p.R450T	PEX1_ENST00000438045.1_Missense_Mutation_p.R128T|PEX1_ENST00000541751.1_5'UTR|PEX1_ENST00000428214.1_Missense_Mutation_p.R450T	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	450					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TAAATTCTCTCTAGGTTGTAA	0.328000													29	77					0	0	0.173368	0	0
PRRX1	5396	broad.mit.edu	37	1	170633362	170633362	+	Translation_Start_Site	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:170633362G>A	ENST00000239461.6	+	1	316	c.3G>A	c.(1-3)atG>atA	p.M1I	PRRX1_ENST00000497230.2_Start_Codon_SNP_p.M1I|PRRX1_ENST00000367760.3_Start_Codon_SNP_p.M1I	NM_022716.2	NP_073207.1	P54821	PRRX1_HUMAN	paired related homeobox 1	1						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGGAGACCATGACCTCCAGCT	0.657000													4	13					0	0	0.150653	0	0
SLC7A6	9057	broad.mit.edu	37	16	68308901	68308901	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:68308901C>G	ENST00000566454.1	+	4	541	c.272C>G	c.(271-273)tCt>tGt	p.S91C	SLC7A6_ENST00000219343.6_Missense_Mutation_p.S91C	NM_001076785.2	NP_001070253.1	Q92536	YLAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6	91					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	16		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		GGGCTCTTCTCTGTTGTGGGT	0.547000													33	48					0	0	0.290176	0	0
IBTK	25998	broad.mit.edu	37	6	82927697	82927697	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:82927697C>G	ENST00000306270.7	-	10	1955	c.1406G>C	c.(1405-1407)aGa>aCa	p.R469T	IBTK_ENST00000503631.1_Missense_Mutation_p.R469T|IBTK_ENST00000510291.1_Missense_Mutation_p.R469T	NM_015525.2	NP_056340.2	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton agammaglobulinemia tyrosine kinase	469					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(10)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	54		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		AGAACTCTTTCTTTTCTCTTC	0.318000													9	29					0	0	0.361761	0	0
MED24	9862	broad.mit.edu	37	17	38192035	38192035	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38192035G>A	ENST00000394126.1	-	4	759	c.341C>T	c.(340-342)tCt>tTt	p.S114F	MED24_ENST00000394128.2_Missense_Mutation_p.S89F|MED24_ENST00000479829.1_5'UTR|MED24_ENST00000394127.2_Missense_Mutation_p.S76F|MED24_ENST00000501516.3_Missense_Mutation_p.S89F|MED24_ENST00000356271.3_Missense_Mutation_p.S76F			O75448	MED24_HUMAN	mediator complex subunit 24	89					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	41	Colorectal(19;0.000442)					CAGGTCCCGAGAAAAGTCATC	0.532000													8	47					0	0	0.307466	0	0
PRICKLE3	4007	broad.mit.edu	37	X	49040229	49040229	+	Silent	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:49040229C>A	ENST00000376317.3	-	3	364	c.270G>T	c.(268-270)tcG>tcT	p.S90S	PRICKLE3_ENST00000536904.1_Silent_p.S22S|PRICKLE3_ENST00000376310.3_Silent_p.S90S|PRICKLE3_ENST00000540849.1_Silent_p.S22S|PRICKLE3_ENST00000538114.1_Silent_p.S90S	NM_006150.3	NP_006141.2	O43900	PRIC3_HUMAN	prickle homolog 3 (Drosophila)	90	PET.						protein binding|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|skin(2)	22						CATACTCCTCCGATGCACAGC	0.617000													23	10					4.74835e-14	5.2073e-14	0.396831	1	0
LRP6	4040	broad.mit.edu	37	12	12318175	12318175	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:12318175G>T	ENST00000261349.4	-	8	1676	c.1600C>A	c.(1600-1602)Cac>Aac	p.H534N	LRP6_ENST00000543091.1_Missense_Mutation_p.H534N	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	534	Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				CCAAATATGTGAGGAATTTTG	0.398000													58	126					4.97629e-18	5.60307e-18	0.323286	1	0
DZIP1L	199221	broad.mit.edu	37	3	137822364	137822364	+	Silent	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:137822364G>T	ENST00000327532.2	-	2	812	c.450C>A	c.(448-450)atC>atA	p.I150I	DZIP1L_ENST00000469243.1_Silent_p.I150I	NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	150						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						GCAGGGTGCTGATCATCTTGC	0.662000													12	26					2.27111e-07	2.38851e-07	0.093190	1	0
FRMD4B	23150	broad.mit.edu	37	3	69246184	69246184	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:69246184G>C	ENST00000542259.1	-	14	1248	c.797C>G	c.(796-798)tCa>tGa	p.S266*	FRMD4B_ENST00000398540.3_Nonsense_Mutation_p.S320*|FRMD4B_ENST00000478263.1_5'UTR			Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	320	FERM.					cytoplasm|cytoskeleton	binding			NS(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(2)	19		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		TCTTGAAACTGAAATCCTGAA	0.418000													13	19					0	0	0.160694	0	0
CUEDC1	404093	broad.mit.edu	37	17	55948723	55948723	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:55948723C>A	ENST00000577830.1	-	6	1205	c.792G>T	c.(790-792)ttG>ttT	p.L264F	CUEDC1_ENST00000407144.2_Missense_Mutation_p.L264F|CUEDC1_ENST00000577840.1_Missense_Mutation_p.L127F|CUEDC1_ENST00000360238.2_Missense_Mutation_p.L264F	NM_001271875.1	NP_001258804.1	Q9NWM3	CUED1_HUMAN	CUE domain containing 1	264										endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12						ATTCGTATTTCAATCGATCTG	0.527000													9	35					0.335167	0.336307	0.335167	1	0
RANBP2	5903	broad.mit.edu	37	2	109383783	109383783	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:109383783C>G	ENST00000283195.6	+	20	6914	c.6788C>G	c.(6787-6789)tCa>tGa	p.S2263*		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2263					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TTTGGTGAGTCAACAACAGGA	0.418000													50	297					0	0	0.323286	0	0
SYNE1	23345	broad.mit.edu	37	6	152631862	152631862	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:152631862C>G	ENST00000367255.5	-	88	17458	c.16857G>C	c.(16855-16857)atG>atC	p.M5619I	SYNE1_ENST00000341594.5_Missense_Mutation_p.M5231I|SYNE1_ENST00000265368.4_Missense_Mutation_p.M5619I|SYNE1_ENST00000448038.1_Missense_Mutation_p.M5548I|SYNE1_ENST00000356820.4_Missense_Mutation_p.M143I|SYNE1_ENST00000423061.1_Missense_Mutation_p.M5548I	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5619					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAATTTTGATCATCTGTCGCA	0.383000										HNSCC(10;0.0054)			15	23					0	0	0.189662	0	0
PALLD	23022	broad.mit.edu	37	4	169433469	169433469	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:169433469C>G	ENST00000261509.6	+	2	1025	c.814C>G	c.(814-816)Cga>Gga	p.R272G	PALLD_ENST00000505667.1_Missense_Mutation_p.R272G|PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000333488.4_Missense_Mutation_p.R149G	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	272	Ig-like C2-type 1.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		AGCTGCACCTCGATTCATCCA	0.567000									Pancreatic Cancer, Familial Clustering of				4	41					0	0	0.217242	0	0
PIP4K2B	8396	broad.mit.edu	37	17	36935741	36935741	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:36935741G>C	ENST00000269554.3	-	5	1029	c.549C>G	c.(547-549)ttC>ttG	p.F183L	PIP4K2B_ENST00000311500.6_5'UTR	NM_003559.4	NP_003550.1	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	183	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)	19						ACATGCCCAGGAACTGTGGCA	0.522000													17	42					0	0	0.160694	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102552620	102552620	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:102552620C>G	ENST00000334701.7	-	3	743	c.462G>C	c.(460-462)ttG>ttC	p.L154F	HSP90AA1_ENST00000441629.2_5'UTR|HSP90AA1_ENST00000216281.8_Missense_Mutation_p.L32F	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	32					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	TATTGATGATCAATGACATCA	0.443000													27	71					0	0	0.324025	0	0
ATP8B1	5205	broad.mit.edu	37	18	55351394	55351394	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:55351394C>T	ENST00000536015.1	-	15	1623	c.1504G>A	c.(1504-1506)Gat>Aat	p.D502N	RP11-35G9.3_ENST00000599199.1_RNA|ATP8B1_ENST00000283684.4_Missense_Mutation_p.D502N|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	502					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				AGCTTCCCATCAGCATATGTA	0.348000													9	33					0	0	0.361761	0	0
ZMYM4	9202	broad.mit.edu	37	1	35885249	35885249	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:35885249G>C	ENST00000314607.6	+	30	4698	c.4618G>C	c.(4618-4620)Gaa>Caa	p.E1540Q	ZMYM4_ENST00000373297.2_Missense_Mutation_p.E1451Q	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	1540					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGCCAAATCTGAAGACTCTGA	0.423000													12	32					0	0	0.105934	0	0
EIF5B	9669	broad.mit.edu	37	2	100006265	100006265	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:100006265G>A	ENST00000289371.6	+	15	2558	c.2356G>A	c.(2356-2358)Gaa>Aaa	p.E786K		NM_015904.3	NP_056988.3	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B						regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TACAAAAGATGAATTTGAGGA	0.353000													31	53					0	0	0.246493	0	0
SLC25A12	8604	broad.mit.edu	37	2	172691273	172691273	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:172691273G>C	ENST00000422440.2	-	7	752	c.715C>G	c.(715-717)Cta>Gta	p.L239V	SLC25A12_ENST00000392592.4_Missense_Mutation_p.L132V	NM_003705.4	NP_003696.2	O75746	CMC1_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 12	239					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|upper_aerodigestive_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	GTGCCAGCTAGAGTGCTATAT	0.373000													34	105					0	0	0.301197	0	0
FETUB	26998	broad.mit.edu	37	3	186370280	186370280	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:186370280G>A	ENST00000265029.3	+	7	1110	c.1009G>A	c.(1009-1011)Gaa>Aaa	p.E337K	RP11-134F2.2_ENST00000455926.1_RNA|FETUB_ENST00000539949.1_Missense_Mutation_p.E189K|FETUB_ENST00000450521.1_Missense_Mutation_p.E337K|RP11-134F2.2_ENST00000428501.1_RNA|FETUB_ENST00000382134.3_Missense_Mutation_p.E272K|FETUB_ENST00000382136.3_Missense_Mutation_p.E300K	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	337						extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		TCCCCAGGGAGAAACCCTGGA	0.522000													17	98					0	0	0.234183	0	0
DLEC1	9940	broad.mit.edu	37	3	38138129	38138129	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:38138129G>A	ENST00000308059.6	+	15	2262	c.2241G>A	c.(2239-2241)gtG>gtA	p.V747V	DLEC1_ENST00000346219.3_Silent_p.V747V|DLEC1_ENST00000452631.2_Silent_p.V747V			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	747					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		AAATCGAGGTGAAAGGCTCAG	0.493000													43	77					0	0	0.323286	0	0
TMEM131	23505	broad.mit.edu	37	2	98409038	98409038	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:98409038C>T	ENST00000186436.5	-	31	4183	c.3955G>A	c.(3955-3957)Gaa>Aaa	p.E1319K		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1319	Pro-rich.					integral to membrane		p.E1206Q(1)|p.E1206*(1)|p.E1319Q(1)		NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						GACAGCCTTTCAGGCTGCGGC	0.677000													7	20					0	0	0.278610	0	0
EDC4	23644	broad.mit.edu	37	16	67917616	67917616	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67917616G>C	ENST00000358933.5	+	28	4234	c.3995G>C	c.(3994-3996)cGa>cCa	p.R1332P	CTC-479C5.10_ENST00000572067.1_lincRNA	NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	1332					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CTTGGCACTCGAACTGACCTC	0.617000											OREG0023890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	220					0	0	0.323286	0	0
CD7	924	broad.mit.edu	37	17	80274738	80274738	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:80274738C>G	ENST00000584284.1	-	2	283	c.202G>C	c.(202-204)Gac>Cac	p.D68H	CD7_ENST00000583376.1_5'UTR|CD7_ENST00000312648.3_Missense_Mutation_p.D68H|CD7_ENST00000578509.1_5'UTR			P09564	CD7_HUMAN	CD7 molecule	68	Ig-like.				immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|membrane fraction|plasma membrane	receptor activity			endometrium(1)|large_intestine(1)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0667)			TAAATGATGTCTTGGGGCTGT	0.632000													24	55					0	0	0.338820	0	0
RASL11B	65997	broad.mit.edu	37	4	53728708	53728708	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:53728708G>A	ENST00000248706.3	+	1	252	c.34G>A	c.(34-36)Gag>Aag	p.E12K		NM_023940.2	NP_076429.1	Q9BPW5	RSLBB_HUMAN	RAS-like, family 11, member B	12					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			autonomic_ganglia(1)|central_nervous_system(1)|lung(5)|ovary(1)|stomach(1)	9			LUSC - Lung squamous cell carcinoma(32;0.0302)			CACCATCGCCGAGTACCCCGC	0.731000													7	25					0	0	0.278610	0	0
BRWD1	54014	broad.mit.edu	37	21	40627734	40627734	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:40627734C>G	ENST00000342449.3	-	19	2170	c.2092G>C	c.(2092-2094)Gac>Cac	p.D698H	BRWD1_ENST00000333229.2_Missense_Mutation_p.D698H|BRWD1_ENST00000380800.3_Missense_Mutation_p.D698H	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	698					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GACTGAATGTCTAAGCTCAGC	0.418000													14	65					0	0	0.132662	0	0
USP9Y	8287	broad.mit.edu	37	Y	14898191	14898191	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrY:14898191G>T	ENST00000338981.3	+	23	4151	c.3206G>T	c.(3205-3207)gGa>gTa	p.G1069V	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	1069					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GCAAAACTTGGAGAAGGCAAA	0.398000													14	51					1.02788e-11	1.10465e-11	0.160694	1	0
SLC35F1	222553	broad.mit.edu	37	6	118588187	118588187	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:118588187G>A	ENST00000360388.4	+	4	708	c.507G>A	c.(505-507)gtG>gtA	p.V169V		NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	169					transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		TCCCAGTCGTGATTTTGCTCT	0.502000													56	332					0	0	0.323286	0	0
SV2B	9899	broad.mit.edu	37	15	91835762	91835762	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:91835762C>G	ENST00000394232.1	+	13	2502	c.2032C>G	c.(2032-2034)Cga>Gga	p.R678G	SV2B_ENST00000545111.2_Missense_Mutation_p.R527G|SV2B_ENST00000330276.4_Missense_Mutation_p.R678G	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	678					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GCCAGAGACTCGAGAACAGGT	0.512000													18	105					0	0	0.234183	0	0
TXNDC16	57544	broad.mit.edu	37	14	52905928	52905928	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:52905928G>C	ENST00000281741.4	-	20	2559	c.2188C>G	c.(2188-2190)Cat>Gat	p.H730D		NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	730					cell redox homeostasis	extracellular region				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					TTACTGATATGATTTTCTAGT	0.333000													9	41					0	0	0.361761	0	0
CAP1	10487	broad.mit.edu	37	1	40529930	40529930	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:40529930C>G	ENST00000372797.3	+	5	887	c.326C>G	c.(325-327)tCa>tGa	p.S109*	CAP1_ENST00000372805.3_Nonsense_Mutation_p.S109*|CAP1_ENST00000372792.2_Nonsense_Mutation_p.S109*|CAP1_ENST00000372798.1_Nonsense_Mutation_p.S108*|CAP1_ENST00000340450.3_Nonsense_Mutation_p.S108*|CAP1_ENST00000372802.1_Nonsense_Mutation_p.S108*	NM_001105530.1|NM_006367.3	NP_001099000|NP_006358	Q01518	CAP1_HUMAN	CAP, adenylate cyclase-associated protein 1 (yeast)	109					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	12	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCACCCATCTCAGAGCAGATC	0.448000													21	66					0	0	0.294199	0	0
MICA	100507436	broad.mit.edu	37	6	31382788	31382788	+	Splice_Site	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:31382788G>A	ENST00000449934.2	+	6	1082		c.e6-1		HCP5_ENST00000414046.2_RNA	NM_001177519.1	NP_001170990.1	Q29983	MICA_HUMAN	MHC class I polypeptide-related sequence A						antigen processing and presentation|cytolysis|defense response to bacterium|defense response to virus|gamma-delta T cell activation|immune response to tumor cell|response to DNA damage stimulus|response to heat|stimulatory C-type lectin receptor signaling pathway	cell surface|cytoplasm|extracellular space|integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			breast(1)|endometrium(3)|kidney(1)	5		Ovarian(999;0.0253)				CTTTTCTCCAGAGCTCGTGAG	0.522000													9	73					0	0	0.387290	0	0
TAF1B	9014	broad.mit.edu	37	2	10008450	10008450	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:10008450G>A	ENST00000263663.5	+	6	633	c.445G>A	c.(445-447)Gag>Aag	p.E149K	TAF1B_ENST00000402170.1_3'UTR|TAF1B_ENST00000396242.3_5'UTR	NM_005680.2	NP_005671	Q53T94	TAF1B_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	149					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TAGTGAGCCTGAGCTGCTAAG	0.398000													19	48					0	0	0.324025	0	0
KCND2	3751	broad.mit.edu	37	7	120385895	120385895	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:120385895A>G	ENST00000331113.4	+	5	2494	c.1529A>G	c.(1528-1530)aAt>aGt	p.N510S		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	510					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GCAACTGTTAATCGTCCTTCA	0.438000													27	51					0	0	0.368089	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070334	114070334	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:114070334C>T	ENST00000462705.1	-	11	1193	c.372G>A	c.(370-372)gtG>gtA	p.V124V	ZBTB20_ENST00000357258.3_Silent_p.V124V|ZBTB20_ENST00000471418.1_Silent_p.V124V|ZBTB20_ENST00000464560.1_Silent_p.V124V|ZBTB20_ENST00000481632.1_Silent_p.V124V|ZBTB20_ENST00000393785.2_Silent_p.V124V|ZBTB20_ENST00000474710.1_Silent_p.V197V	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	197	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		ACACATCGCCCACGTTCTGTG	0.652000													10	79					0	0	0.387290	0	0
HMG20A	10363	broad.mit.edu	37	15	77770687	77770687	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:77770687G>T	ENST00000381714.3	+	9	1170	c.742G>T	c.(742-744)Gag>Tag	p.E248*	HMG20A_ENST00000336216.4_Nonsense_Mutation_p.E248*	NM_018200.2	NP_060670.1	Q9NP66	HM20A_HUMAN	high mobility group 20A	248					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						GGAGTTTGAGGAGAGGAATGC	0.557000													26	64					4.87955e-14	5.34126e-14	0.324025	1	0
BRINP3	339479	broad.mit.edu	37	1	190195374	190195374	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:190195374A>T	ENST00000367462.3	-	6	1030	c.799T>A	c.(799-801)Tca>Aca	p.S267T	BRINP3_ENST00000534846.1_Missense_Mutation_p.S165T	NM_199051.1	NP_950252.1			bone morphogenetic protein/retinoic acid inducible neural-specific 3	267																	TCTCCCTCTGAATTGCAAGCA	0.438000													19	60					0	0	0.279207	0	0
SMG5	23381	broad.mit.edu	37	1	156237348	156237348	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156237348C>G	ENST00000361813.5	-	10	1174	c.1030G>C	c.(1030-1032)Gag>Cag	p.E344Q	SMG5_ENST00000368267.5_Intron|SMG5_ENST00000489907.2_5'UTR	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	344					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					TATCCACTCTCATACTCCTCC	0.527000													9	91					0	0	0.387290	0	0
REG1P	5969	broad.mit.edu	37	2	79364079	79364079	+	RNA	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:79364079C>A	ENST00000444841.1	-	0	285																											ATGGAGCACTCAGTGAAGGAG	0.502000													16	61					1.78486e-19	2.03688e-19	0.189662	1	0
NFE2L2	4780	broad.mit.edu	37	2	178097233	178097233	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:178097233G>C	ENST00000397062.3	-	4	1035	c.481C>G	c.(481-483)Cag>Gag	p.Q161E	NFE2L2_ENST00000423513.1_3'UTR|NFE2L2_ENST00000446151.2_Missense_Mutation_p.Q138E|NFE2L2_ENST00000464747.1_Missense_Mutation_p.Q145E|NFE2L2_ENST00000397063.4_Missense_Mutation_p.Q145E	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	161					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			GACTGAGCCTGATTAGTAGCA	0.448000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			9	56					0	0	0.335167	0	0
FRY	10129	broad.mit.edu	37	13	32808828	32808828	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:32808828C>A	ENST00000380250.3	+	42	6141	c.5645C>A	c.(5644-5646)tCa>tAa	p.S1882*		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1882					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CAACCTCTGTCAGCACATGCC	0.512000													17	41					4.35082e-09	4.62519e-09	0.219247	1	0
HSP90AA1	3320	broad.mit.edu	37	14	102551299	102551299	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:102551299C>A	ENST00000334701.7	-	6	1347	c.1066G>T	c.(1066-1068)Gag>Tag	p.E356*	HSP90AA1_ENST00000441629.2_Nonsense_Mutation_p.E55*|HSP90AA1_ENST00000216281.8_Nonsense_Mutation_p.E234*	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	234					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	tcttcAGCCTCATCATCGCTT	0.418000													11	26					2.80697e-09	2.98938e-09	0.387290	1	0
SPATA2L	124044	broad.mit.edu	37	16	89763774	89763774	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:89763774G>C	ENST00000289805.5	-	3	1311	c.1243C>G	c.(1243-1245)Ctg>Gtg	p.L415V	SPATA2L_ENST00000335360.7_Intron	NM_152339.3	NP_689552.2	Q8IUW3	SPA2L_HUMAN	spermatogenesis associated 2-like	415										breast(1)|cervix(1)|endometrium(1)|lung(2)|skin(1)	6		Lung NSC(15;0.00043)|all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		TTGTAGAGCAGAGTGTCCATC	0.687000													4	14					0	0	0.150653	0	0
HIPK3	10114	broad.mit.edu	37	11	33370177	33370177	+	Nonsense_Mutation	SNP	C	C	T	rs150770633		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:33370177C>T	ENST00000303296.4	+	13	2784	c.2479C>T	c.(2479-2481)Cag>Tag	p.Q827*	HIPK3_ENST00000456517.1_Nonsense_Mutation_p.Q806*|HIPK3_ENST00000525975.1_Nonsense_Mutation_p.Q806*|HIPK3_ENST00000379016.3_Nonsense_Mutation_p.Q806*	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	827	Interaction with AR (By similarity).|Interaction with FAS (By similarity).				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						ACAGGACAATCAGAACTCAGA	0.378000													36	42					0	0	0.235728	0	0
SYMPK	8189	broad.mit.edu	37	19	46345718	46345718	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:46345718G>A	ENST00000245934.7	-	9	1121	c.877C>T	c.(877-879)Cag>Tag	p.Q293*		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	293					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CTGCTCACCTGCGATTTGGCC	0.562000													15	80					0	0	0.219247	0	0
SEC24A	10802	broad.mit.edu	37	5	134029515	134029515	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:134029515G>A	ENST00000398844.2	+	13	2166	c.1878G>A	c.(1876-1878)ctG>ctA	p.L626L		NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	626					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTTTAAGCTGATGTCTCCAA	0.498000													9	48					0	0	0.335167	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107446552	107446552	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:107446552G>T	ENST00000409382.3	-	5	1898	c.1288C>A	c.(1288-1290)Caa>Aaa	p.Q430K	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.Q430K|ST6GAL2_ENST00000409087.3_Missense_Mutation_p.Q430K	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	430					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						GGGTTTGGTTGAATCTTCTCT	0.368000													40	126					5.44703e-19	6.16842e-19	0.279185	1	0
MALAT1	378938	broad.mit.edu	37	11	65273495	65273495	+	RNA	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65273495G>A	ENST00000534336.1	+	0	8263					NR_002819.2																						GTAGGGTCATGAAGGTTTTTC	0.378000													13	28					0	0	0.105934	0	0
QRICH1	54870	broad.mit.edu	37	3	49094498	49094498	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49094498G>A	ENST00000395443.2	-	3	1607	c.1135C>T	c.(1135-1137)Ctt>Ttt	p.L379F	QRICH1_ENST00000424300.1_Missense_Mutation_p.L379F|QRICH1_ENST00000479449.1_Intron|QRICH1_ENST00000357496.2_Missense_Mutation_p.L379F	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	379	Gln-rich.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GAGTTTGCAAGGGTCTGCACT	0.522000													24	55					0	0	0.309145	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32217653	32217653	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:32217653G>A	ENST00000492345.1	+	10	1786	c.1101G>A	c.(1099-1101)ctG>ctA	p.L367L	CBFA2T2_ENST00000491618.1_3'UTR|CBFA2T2_ENST00000397800.1_Silent_p.L367L|CBFA2T2_ENST00000342704.6_Silent_p.L387L|CBFA2T2_ENST00000346541.3_Silent_p.L396L|CBFA2T2_ENST00000359606.3_Silent_p.L406L|CBFA2T2_ENST00000375279.2_Silent_p.L396L			O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	396						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						ACACAGAGCTGAGGAAAACGG	0.507000													5	34					0	0	0.217242	0	0
ANKHD1	54882	broad.mit.edu	37	5	139916980	139916980	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:139916980C>G	ENST00000297183.6	+	31	7158	c.7034C>G	c.(7033-7035)tCt>tGt	p.S2345C	ANKHD1_ENST00000544120.1_Missense_Mutation_p.S669C|ANKHD1_ENST00000360839.2_Missense_Mutation_p.S2345C|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.S2345C	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGCCACTTCTGCCCCACCA	0.453000													25	91					0	0	0.396831	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	62					0	0	0.248553	0	0
HEATR6	63897	broad.mit.edu	37	17	58123500	58123500	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:58123500C>G	ENST00000184956.6	-	19	2876	c.2860G>C	c.(2860-2862)Gag>Cag	p.E954Q	HEATR6_ENST00000585976.1_Missense_Mutation_p.E842Q	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	954							binding	p.E954Q(1)		NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			ATAGACTCCTCAATGATTTCT	0.393000													25	62					0	0	0.368089	0	0
MSLN	10232	broad.mit.edu	37	16	814666	814666	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:814666G>A	ENST00000566549.1	+	6	737	c.320G>A	c.(319-321)cGg>cAg	p.R107Q	MSLN_ENST00000545450.2_Missense_Mutation_p.R107Q|MSLN_ENST00000382862.3_Missense_Mutation_p.R107Q|MSLN_ENST00000563941.1_Missense_Mutation_p.R107Q			Q13421	MSLN_HUMAN	mesothelin	107					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				CTGGCTCACCGGCTCTCTGAG	0.682000													53	127					0	0	0.323286	0	0
NT5DC3	51559	broad.mit.edu	37	12	104187715	104187715	+	Splice_Site	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:104187715C>G	ENST00000392876.3	-	7	854	c.814G>C	c.(814-816)Gaa>Caa	p.E272Q		NM_001031701.2	NP_001026871.1	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	272							hydrolase activity|metal ion binding			NS(1)|breast(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|ovary(2)|skin(1)|stomach(2)	30						GAGCACATACCAATGTCTGCT	0.413000													21	80					0	0	0.368089	0	0
MALAT1	378938	broad.mit.edu	37	11	65273350	65273350	+	RNA	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65273350G>T	ENST00000534336.1	+	0	8118					NR_002819.2																						GTAGACTGGAGAAGATAGGCA	0.413000													31	75					6.29468e-14	6.87753e-14	0.214465	1	0
KIF3C	3797	broad.mit.edu	37	2	26204353	26204353	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:26204353T>C	ENST00000264712.3	-	1	1013	c.434A>G	c.(433-435)tAt>tGt	p.Y145C	KIF3C_ENST00000405914.1_Missense_Mutation_p.Y145C	NM_002254.6	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	145	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GATCTCCAAATAGGAGGCCCG	0.582000													31	71					0	0	0.203993	0	0
UGP2	7360	broad.mit.edu	37	2	64083559	64083559	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:64083559G>C	ENST00000337130.5	+	2	615	c.139G>C	c.(139-141)Gaa>Caa	p.E47Q	UGP2_ENST00000487469.1_Intron|UGP2_ENST00000467648.2_Missense_Mutation_p.E36Q|UGP2_ENST00000445915.2_Missense_Mutation_p.E56Q|UGP2_ENST00000394417.2_Missense_Mutation_p.E36Q	NM_006759.3	NP_006750.3	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2	47					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)	18						ATCATCACATGAATTTGAGGT	0.458000													34	217					0	0	0.312237	0	0
GABARAPL3	23766	broad.mit.edu	37	15	90892196	90892196	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:90892196G>C	ENST00000412799.2	-	1	473	c.234C>G	c.(232-234)ttC>ttG	p.F78L																								TGTTGACAAAGAAGAATAAGG	0.478000													23	50					0	0	0.309145	0	0
PLIN3	10226	broad.mit.edu	37	19	4859922	4859922	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:4859922C>T	ENST00000221957.4	-	3	357	c.181G>A	c.(181-183)Gac>Aac	p.D61N	PLIN3_ENST00000585479.1_Missense_Mutation_p.D61N|PLIN3_ENST00000592528.1_Missense_Mutation_p.D61N	NM_001164189.1|NM_001164194.1|NM_005817.4	NP_001157661.1|NP_001157666.1|NP_005808.3	O60664	PLIN3_HUMAN	perilipin 3	61					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9					Galsulfase(DB01279)|Idursulfase(DB01271)	TCTGCTGCGTCGCAGACAGTC	0.637000													3	25					0	0	0.184627	0	0
MRPL41	64975	broad.mit.edu	37	9	140446562	140446562	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140446562G>A	ENST00000371443.5	+	2	817	c.29G>A	c.(28-30)tGc>tAc	p.C10Y		NM_032477.2	NP_115866.1	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	10					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			breast(1)|lung(1)	2	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		GCGGCGCGCTGCCTGGTCCGG	0.776000													7	9					0	0	0.335167	0	0
PHLDB2	90102	broad.mit.edu	37	3	111686606	111686606	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:111686606G>A	ENST00000431670.2	+	15	3661	c.3250G>A	c.(3250-3252)Gaa>Aaa	p.E1084K	PHLDB2_ENST00000495180.1_Missense_Mutation_p.E575K|PHLDB2_ENST00000481953.1_Missense_Mutation_p.E1041K|PHLDB2_ENST00000393925.3_Missense_Mutation_p.E1084K|PHLDB2_ENST00000393923.3_Missense_Mutation_p.E1068K|PHLDB2_ENST00000412622.1_Missense_Mutation_p.E1041K	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	1084						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						ATTACAGGAAGAAACTAGCCA	0.433000											OREG0015707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	22					0	0	0.217242	0	0
TRDMT1	1787	broad.mit.edu	37	10	17195630	17195630	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:17195630C>G	ENST00000377799.3	-	10	998	c.951G>C	c.(949-951)gaG>gaC	p.E317D	TRDMT1_ENST00000488990.1_Missense_Mutation_p.E194D|TRDMT1_ENST00000412821.3_Missense_Mutation_p.E293D|TRDMT1_ENST00000351358.4_Missense_Mutation_p.E271D|TRDMT1_ENST00000377766.5_3'UTR|TRDMT1_ENST00000358282.7_3'UTR|TRDMT1_ENST00000457442.2_Missense_Mutation_p.E236D|TRDMT1_ENST00000452380.2_5'UTR	NM_004412.5	NP_004403.1	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1	317					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	18						TGTAGATATTCTCAACCTGTA	0.333000													4	18					0	0	0.217242	0	0
DSCAML1	57453	broad.mit.edu	37	11	117302289	117302289	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:117302289C>G	ENST00000321322.6	-	31	5516	c.5515G>C	c.(5515-5517)Gag>Cag	p.E1839Q	DSCAML1_ENST00000527706.1_Missense_Mutation_p.E1569Q	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1779					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CTGTCACTCTCAGTGACCGTG	0.632000													21	59					0	0	0.249174	0	0
DOK2	9046	broad.mit.edu	37	8	21767094	21767094	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:21767094G>C	ENST00000276420.4	-	5	1225	c.967C>G	c.(967-969)Cag>Gag	p.Q323E	DOK2_ENST00000544659.1_Missense_Mutation_p.Q169E	NM_003974.2	NP_003965.2	O60496	DOK2_HUMAN	docking protein 2, 56kDa	323	Pro-rich.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(3)|skin(1)	26				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GCCAGGAGCTGAGGAGGGACT	0.647000													30	43					0	0	0.410975	0	0
DNMT1	1786	broad.mit.edu	37	19	10286275	10286275	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:10286275G>C	ENST00000340748.4	-	6	776	c.541C>G	c.(541-543)Cag>Gag	p.Q181E	DNMT1_ENST00000540357.1_Missense_Mutation_p.Q181E|DNMT1_ENST00000359526.4_Missense_Mutation_p.Q197E			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	181	Interaction with DNMT3B.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GACTCTTCCTGAGGTTTCCGT	0.512000													23	53					0	0	0.353513	0	0
SYNE1	23345	broad.mit.edu	37	6	152740829	152740829	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:152740829C>G	ENST00000367255.5	-	40	5897	c.5296G>C	c.(5296-5298)Gaa>Caa	p.E1766Q	SYNE1_ENST00000341594.5_Missense_Mutation_p.E1803Q|SYNE1_ENST00000265368.4_Missense_Mutation_p.E1766Q|SYNE1_ENST00000448038.1_Missense_Mutation_p.E1773Q|SYNE1_ENST00000423061.1_Missense_Mutation_p.E1773Q	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1766					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGCTGGTGTTCAGCAACCACA	0.348000										HNSCC(10;0.0054)			11	42					0	0	0.160694	0	0
TLR8	51311	broad.mit.edu	37	X	12938248	12938248	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:12938248C>G	ENST00000218032.6	+	2	1176	c.1089C>G	c.(1087-1089)ttC>ttG	p.F363L	TLR8_ENST00000311912.5_Missense_Mutation_p.F381L	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	363					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						CCAGAAACTTCTCTAAACTTT	0.393000													26	43					0	0	0.353513	0	0
ANGPTL4	51129	broad.mit.edu	37	19	8436324	8436324	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:8436324C>G	ENST00000301455.2	+	6	1128	c.957C>G	c.(955-957)ccC>ccG	p.P319P	ANGPTL4_ENST00000541807.1_Silent_p.P152P|ANGPTL4_ENST00000393962.2_Silent_p.P281P	NM_139314.1	NP_647475.1	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4	319	Fibrinogen C-terminal.				angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			large_intestine(1)|lung(1)|ovary(2)|skin(2)	6						CCGTCCCACCCAGCGGCCTCT	0.667000													5	25					0	0	0.248553	0	0
RPUSD3	285367	broad.mit.edu	37	3	9885243	9885243	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:9885243G>C	ENST00000383820.5	-	2	169	c.168C>G	c.(166-168)ccC>ccG	p.P56P	RPUSD3_ENST00000485705.1_5'UTR|RPUSD3_ENST00000424438.1_Silent_p.P24P|RPUSD3_ENST00000433535.2_Silent_p.P56P|TTLL3_ENST00000455274.1_Intron	NM_173659.3	NP_775930.2	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	56					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(2)|endometrium(3)|lung(2)	7	Medulloblastoma(99;0.227)					GGTCCCCGAGGGGCCCCGACC	0.657000													11	23					0	0	0.093190	0	0
OGDHL	55753	broad.mit.edu	37	10	50966537	50966537	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:50966537G>A	ENST00000374103.4	-	2	187	c.102C>T	c.(100-102)tcC>tcT	p.S34S	OGDHL_ENST00000432695.1_Intron|OGDHL_ENST00000419399.1_Silent_p.S34S	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	34					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CCGGTGGCCCGGAGGACCTGC	0.632000													17	27					0	0	0.189662	0	0
HIST1H2AK	8330	broad.mit.edu	37	6	27805994	27805994	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:27805994C>T	ENST00000330180.2	-	1	123	c.124G>A	c.(124-126)Gag>Aag	p.E42K		NM_003510.2	NP_003501.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	42					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(2)|endometrium(2)|kidney(1)|lung(3)|upper_aerodigestive_tract(2)	10						CCGACCCGCTCAGCGTAGTTG	0.657000													12	38					0	0	0.119110	0	0
ASGR2	433	broad.mit.edu	37	17	7010563	7010563	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:7010563G>A	ENST00000380952.2	-	6	762	c.498C>T	c.(496-498)ctC>ctT	p.L166L	ASGR2_ENST00000355035.5_Silent_p.L166L|ASGR2_ENST00000446679.2_Silent_p.L147L|ASGR2_ENST00000254850.7_Silent_p.L142L	NM_001181.4|NM_001201352.1|NM_080912.3	NP_001172|NP_001188281.1|NP_550434	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2	166					cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|skin(3)|stomach(4)	18					Antihemophilic Factor(DB00025)	TGCTGTGGAGGAGCTCCATCT	0.642000													10	14					0	0	0.387290	0	0
APOBR	55911	broad.mit.edu	37	16	28508751	28508751	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:28508751G>A	ENST00000564831.1	+	2	2422	c.2389G>A	c.(2389-2391)Gag>Aag	p.E797K	APOBR_ENST00000431282.1_Missense_Mutation_p.E788K|APOBR_ENST00000328423.5_Missense_Mutation_p.E788K	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	788	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						AGAAAAGGAAGAGGCAGCAGC	0.572000													6	10					0	0	0.248553	0	0
DDX59	83479	broad.mit.edu	37	1	200594175	200594175	+	Splice_Site	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:200594175C>G	ENST00000447706.2	-	8	1748	c.1597G>C	c.(1597-1599)Gaa>Caa	p.E533Q				Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	0	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|liver(1)|lung(9)|ovary(3)	21						TAGGTATTTTCCTAAAATGGA	0.368000													6	20					0	0	0.248553	0	0
PSME4	23198	broad.mit.edu	37	2	54122166	54122166	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:54122166C>T	ENST00000404125.1	-	34	3945	c.3890G>A	c.(3889-3891)aGa>aAa	p.R1297K	PSME4_ENST00000421748.2_Missense_Mutation_p.R441K	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	1297					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CTCCCTGCTTCTGCCAAGCTT	0.388000													45	127					0	0	0.323286	0	0
MSTN	2660	broad.mit.edu	37	2	190924966	190924966	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190924966C>T	ENST00000260950.4	-	2	701	c.569G>A	c.(568-570)cGa>cAa	p.R190Q	C2orf88_ENST00000478197.1_Intron	NM_005259.2	NP_005250.1	O14793	GDF8_HUMAN	myostatin	190					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)	12			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TTTCAGAGATCGGATTCCAGT	0.428000													43	239					0	0	0.323286	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000392221.1_Silent_p.P45P|EEF1B2_ENST00000236957.5_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													6	249					0	0	0.217242	0	0
SMC4	10051	broad.mit.edu	37	3	160148850	160148850	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:160148850C>T	ENST00000357388.3	+	20	3422	c.2971C>T	c.(2971-2973)Cgc>Tgc	p.R991C	SMC4_ENST00000462787.1_Intron|SMC4_ENST00000469762.1_Missense_Mutation_p.R966C|SMC4_ENST00000344722.5_Missense_Mutation_p.R991C|SMC4_ENST00000360111.2_Intron|RP11-432B6.3_ENST00000483754.1_Intron	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	991					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GAAAGAACATCGCAATCTGCT	0.333000													21	50					0	0	0.249174	0	0
HSF1	3297	broad.mit.edu	37	8	145533476	145533476	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:145533476G>A	ENST00000528838.1	+	4	542	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	HSF1_ENST00000400780.4_Missense_Mutation_p.E63K	NM_005526.2	NP_005517.1	Q00613	HSF1_HUMAN	heat shock transcription factor 1	128						cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(3)|prostate(3)|skin(1)|urinary_tract(2)	11	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			CCTGAAGAGTGAAGACATAAA	0.602000													16	152					0	0	0.264190	0	0
PPAP2A	8611	broad.mit.edu	37	5	54721830	54721830	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:54721830C>G	ENST00000307259.8	-	5	1007	c.587G>C	c.(586-588)aGa>aCa	p.R196T	PPAP2A_ENST00000264775.5_Missense_Mutation_p.R197T	NM_003711.2	NP_003702.2	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A	196					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	9		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				GCGTAAGAGTCTTGCCCAGTC	0.378000													11	55					0	0	0.105934	0	0
CILP2	148113	broad.mit.edu	37	19	19654990	19654990	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:19654990G>A	ENST00000586018.1	+	8	1756	c.1654G>A	c.(1654-1656)Ggc>Agc	p.G552S	CILP2_ENST00000291495.5_Missense_Mutation_p.G546S			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	546						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						TCGAGGTGCCGGCGTGTACCA	0.617000													3	71					0	0	0.115264	0	0
GOLGA2	2801	broad.mit.edu	37	9	131028091	131028091	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:131028091G>A	ENST00000421699.2	-	10	733	c.721C>T	c.(721-723)Cag>Tag	p.Q241*	GOLGA2_ENST00000609374.1_Nonsense_Mutation_p.Q229*	NM_004486.4	NP_004477.3	Q08379	GOGA2_HUMAN	golgin A2	241						Golgi cisterna membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34						GCAGCATGCTGAGTGTGAGCC	0.532000													22	54					0	0	0.353513	0	0
MTF1	4520	broad.mit.edu	37	1	38304297	38304297	+	Splice_Site	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:38304297C>T	ENST00000373036.4	-	4	919	c.779G>A	c.(778-780)cGg>cAg	p.R260Q		NM_005955.2	NP_005946.2	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	260						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding	p.R260Q(1)		endometrium(3)|kidney(5)|large_intestine(6)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)	31	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TAAGACCTACCGAAATGGCTT	0.403000													11	62					0	0	0.119110	0	0
GCLM	2730	broad.mit.edu	37	1	94360257	94360257	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:94360257G>A	ENST00000370238.3	-	6	814	c.568C>T	c.(568-570)Ctt>Ttt	p.L190F	GCLM_ENST00000467772.1_5'UTR	NM_002061.2	NP_002052.1	P48507	GSH0_HUMAN	glutamate-cysteine ligase, modifier subunit	190					glutamate metabolic process|glutathione biosynthetic process|regulation of blood vessel size|response to drug|response to oxidative stress|xenobiotic metabolic process	cytosol|soluble fraction	glutamate-cysteine ligase catalytic subunit binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_lung(203;0.000815)|Lung NSC(277;0.00363)		all cancers(265;0.00566)|GBM - Glioblastoma multiforme(16;0.0203)|Epithelial(280;0.131)	L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	CAGGAGGCAAGATTAACTTGG	0.323000													51	87					0	0	0.323286	0	0
ACPP	55	broad.mit.edu	37	3	132068810	132068810	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:132068810G>C	ENST00000336375.5	+	8	918	c.828G>C	c.(826-828)caG>caC	p.Q276H	ACPP_ENST00000475741.1_Missense_Mutation_p.Q243H|ACPP_ENST00000351273.7_Missense_Mutation_p.Q276H	NM_001099.4	NP_001090.2	P15309	PPAP_HUMAN	acid phosphatase, prostate	276						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(5)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	27						GAGCAACTCAGATACCAAGCT	0.348000													10	61					0	0	0.335167	0	0
SLC6A18	348932	broad.mit.edu	37	5	1245984	1245984	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:1245984G>C	ENST00000324642.3	+	12	1801	c.1678G>C	c.(1678-1680)Gag>Cag	p.E560Q		NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	560					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTCGCGTCAGGAGAAGCTCTA	0.706000													5	34					0	0	0.217242	0	0
MYB	4602	broad.mit.edu	37	6	135539063	135539063	+	Missense_Mutation	SNP	C	C	T	rs148508251		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:135539063C>T	ENST00000341911.5	+	16	2430	c.2231C>T	c.(2230-2232)tCc>tTc	p.S744F	MYB_ENST00000534044.1_Missense_Mutation_p.S586F|MYB_ENST00000533624.1_Missense_Mutation_p.S588F|MYB_ENST00000525369.1_Missense_Mutation_p.S538F|MYB_ENST00000442647.2_Missense_Mutation_p.S620F|MYB_ENST00000534121.1_Missense_Mutation_p.S728F|MYB_ENST00000316528.8_Missense_Mutation_p.S709F|MYB_ENST00000531845.1_3'UTR|MYB_ENST00000528774.1_Missense_Mutation_p.S741F|MYB_ENST00000367814.4_Missense_Mutation_p.S623F	NM_001130173.1|NM_001161656.1|NM_001161658.1	NP_001123645.1|NP_001155128.1|NP_001155130.1	P10242	MYB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog	623					blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		ATGACATCTTCCAGTCAAGCT	0.478000			T	NFIB	adenoid cystic carcinoma								10	69					0	0	0.361761	0	0
MGEA5	10724	broad.mit.edu	37	10	103567511	103567511	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103567511C>T	ENST00000361464.3	-	5	1023	c.628G>A	c.(628-630)Gaa>Aaa	p.E210K	MGEA5_ENST00000439817.1_Missense_Mutation_p.E210K|MGEA5_ENST00000370094.3_Missense_Mutation_p.E210K|MGEA5_ENST00000357797.5_Missense_Mutation_p.E210K|MGEA5_ENST00000419011.2_3'UTR	NM_012215.3	NP_036347.1	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	210					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	23		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		AGGAAAGTTTCTGGCTCTCCT	0.393000													18	114					0	0	0.234183	0	0
USPL1	10208	broad.mit.edu	37	13	31205593	31205593	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:31205593C>T	ENST00000255304.4	+	4	1192	c.850C>T	c.(850-852)Caa>Taa	p.Q284*	USPL1_ENST00000465952.1_3'UTR	NM_005800.4	NP_005791.3	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	284					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(15)|pancreas(3)|skin(3)	34		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		ATATACCAGTCAATTGAGTGG	0.378000													20	62					0	0	0.279207	0	0
GRIN1	2902	broad.mit.edu	37	9	140051206	140051206	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140051206G>A	ENST00000371561.3	+	5	1854	c.757G>A	c.(757-759)Gag>Aag	p.E253K	GRIN1_ENST00000350902.5_Missense_Mutation_p.E253K|GRIN1_ENST00000371546.4_Missense_Mutation_p.E274K|GRIN1_ENST00000371555.4_Missense_Mutation_p.E274K|GRIN1_ENST00000371553.3_Missense_Mutation_p.E274K|GRIN1_ENST00000315048.3_Missense_Mutation_p.E253K|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000371550.4_Missense_Mutation_p.E253K|GRIN1_ENST00000371559.4_Missense_Mutation_p.E253K|GRIN1_ENST00000371560.3_Missense_Mutation_p.E274K	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	253					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CGGCGAGCGCGAGATCTCGGG	0.697000													6	3					0	0	0.248553	0	0
ATIC	471	broad.mit.edu	37	2	216177324	216177324	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:216177324C>T	ENST00000435675.1	+	1	511	c.120C>T	c.(118-120)ctC>ctT	p.L40L	ATIC_ENST00000540518.1_5'UTR|ATIC_ENST00000236959.9_Silent_p.L41L			P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	41					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	large_intestine(2)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	8		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	CAAAAGCTCTCAGGGATGCTG	0.488000			T	ALK	ALCL								22	38					0	0	0.279207	0	0
CELSR3	1951	broad.mit.edu	37	3	48698429	48698429	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48698429C>T	ENST00000544264.1	-	1	1919	c.1639G>A	c.(1639-1641)Gag>Aag	p.E547K	CELSR3_ENST00000164024.4_Missense_Mutation_p.E547K			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	547	Cadherin 3.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TAGCGCTTCTCGCTGAACTGA	0.652000													22	34					0	0	0.279207	0	0
IQGAP1	8826	broad.mit.edu	37	15	91020921	91020921	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:91020921G>C	ENST00000268182.5	+	26	3253	c.3129G>C	c.(3127-3129)gaG>gaC	p.E1043D	IQGAP1_ENST00000560738.1_Missense_Mutation_p.E471D	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1043	C1.|Ras-GAP.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AGATTCAAGAGATTGTGACAG	0.413000													20	72					0	0	0.219247	0	0
TDP1	55775	broad.mit.edu	37	14	90429788	90429788	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:90429788C>G	ENST00000335725.4	+	3	580	c.330C>G	c.(328-330)atC>atG	p.I110M	TDP1_ENST00000555880.1_Missense_Mutation_p.I110M|TDP1_ENST00000555565.1_Intron|TDP1_ENST00000393452.3_Missense_Mutation_p.I110M|TDP1_ENST00000357382.3_5'UTR|TDP1_ENST00000393454.2_Missense_Mutation_p.I110M	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	110					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		AAGTGGTGATCAAAAAGGAGA	0.542000								Repair of DNA-protein crosslinks					24	53					0	0	0.309145	0	0
C1orf61	10485	broad.mit.edu	37	1	156386657	156386657	+	Splice_Site	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156386657C>G	ENST00000368243.1	-	3	92		c.e3-1			NM_006365.1	NP_006356.1	Q13536	CROC4_HUMAN	chromosome 1 open reading frame 61							nucleus				large_intestine(2)|lung(2)|skin(1)	5	Hepatocellular(266;0.158)					TTTTTACATTCTGAAACAAAT	0.388000													13	35					0	0	0.119110	0	0
ALDH1A1	216	broad.mit.edu	37	9	75540481	75540481	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:75540481C>G	ENST00000297785.3	-	6	606	c.552G>C	c.(550-552)ctG>ctC	p.L184L	ALDH1A1_ENST00000376939.1_Silent_p.L184L|ALDH1A1_ENST00000482210.1_5'UTR	NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	184					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTCCACAGCTCAGTGCAGGCC	0.423000													24	30					0	0	0.309145	0	0
CSNK2B	1460	broad.mit.edu	37	6	31635728	31635728	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:31635728G>T	ENST00000375880.2	+	3	274	c.156G>T	c.(154-156)atG>atT	p.M52I	CSNK2B_ENST00000375882.2_Missense_Mutation_p.M52I|CSNK2B_ENST00000375866.2_Missense_Mutation_p.M52I|CSNK2B_ENST00000375865.2_Missense_Mutation_p.M52I|CSNK2B_ENST00000375885.4_Missense_Mutation_p.M71I																							CTCTAGACATGATCTTGGACC	0.458000													8	55					0.00185496	0.00190335	0.105934	1	0
DLEC1	9940	broad.mit.edu	37	3	38136557	38136557	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:38136557C>T	ENST00000308059.6	+	13	2128	c.2107C>T	c.(2107-2109)Cat>Tat	p.H703Y	DLEC1_ENST00000346219.3_Missense_Mutation_p.H703Y|DLEC1_ENST00000452631.2_Missense_Mutation_p.H703Y			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	703					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CTTTTCTCCTCATGAGGTTCA	0.527000													15	53					0	0	0.204396	0	0
MEIS1	4211	broad.mit.edu	37	2	66795861	66795861	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:66795861C>T	ENST00000488550.1	+	11	1386	c.1087C>T	c.(1087-1089)Cag>Tag	p.Q363*	MEIS1_ENST00000444274.2_3'UTR|MEIS1_ENST00000495021.2_Nonsense_Mutation_p.Q298*|MEIS1_ENST00000398506.2_Nonsense_Mutation_p.Q361*|MEIS1_ENST00000409517.1_3'UTR|MEIS1_ENST00000272369.9_Nonsense_Mutation_p.Q363*|MEIS1_ENST00000407092.2_Nonsense_Mutation_p.Q363*			O00470	MEIS1_HUMAN	Meis homeobox 1	363	Required for transcriptional activation (By similarity).						sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	24						AATGGACGGTCAGCAACATAT	0.408000													98	255					0	0	0.323286	0	0
NRBP2	340371	broad.mit.edu	37	8	144921499	144921499	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:144921499G>C	ENST00000442628.2	-	6	706	c.567C>G	c.(565-567)atC>atG	p.I189M	NRBP2_ENST00000327830.5_De_novo_Start_InFrame	NM_178564.3	NP_848659.2	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	189	Protein kinase.				negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)|kidney(1)|large_intestine(2)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AGCCGATCTTGATGAGGCCGT	0.657000													3	28					0	0	0.150653	0	0
RABGGTA	5875	broad.mit.edu	37	14	24738898	24738898	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:24738898G>A	ENST00000399409.3	-	5	913	c.430C>T	c.(430-432)Cac>Tac	p.H144Y	RABGGTA_ENST00000216840.6_Missense_Mutation_p.H144Y|RABGGTA_ENST00000560777.1_5'UTR|RABGGTA_ENST00000559586.1_5'UTR	NM_004581.5	NP_004572.3	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase, alpha subunit	144					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	12				GBM - Glioblastoma multiforme(265;0.0184)		TCCCAGCAGTGAACTGGAGGG	0.587000													11	13					0	0	0.093190	0	0
MUC17	140453	broad.mit.edu	37	7	100679360	100679360	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:100679360C>G	ENST00000306151.4	+	3	4727	c.4663C>G	c.(4663-4665)Cct>Gct	p.P1555A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1555	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGTTCATCTCCTACAACTGC	0.493000													70	437					0	0	0.323286	0	0
MPZL2	10205	broad.mit.edu	37	11	118128003	118128003	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:118128003C>G	ENST00000278937.2	-	5	738	c.610G>C	c.(610-612)Gag>Cag	p.E204Q	MPZL2_ENST00000438295.2_Missense_Mutation_p.E204Q	NM_005797.3	NP_005788.1	O60487	MPZL2_HUMAN	myelin protein zero-like 2	204					anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|skin(1)	11	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		ACCTTTTTCTCTTGGTTGAGC	0.388000													12	84					0	0	0.105934	0	0
CCDC15	80071	broad.mit.edu	37	11	124857585	124857585	+	Missense_Mutation	SNP	C	C	A	rs112861775		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:124857585C>A	ENST00000529051.1	+	8	1722	c.1463C>A	c.(1462-1464)cCc>cAc	p.P488H	CCDC15_ENST00000344762.5_Missense_Mutation_p.P488H			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	488						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CATGTTCTCCCCAAAGACCAA	0.403000													4	145					0.150653	0.151682	0.150653	1	0
TAF4	6874	broad.mit.edu	37	20	60575694	60575694	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:60575694G>A	ENST00000252996.4	-	10	2569	c.2570C>T	c.(2569-2571)tCt>tTt	p.S857F		NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa						interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.S857C(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			CACCAATTCAGAGTTCGTGGC	0.443000													40	52					0	0	0.290176	0	0
MYH6	4624	broad.mit.edu	37	14	23858626	23858626	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23858626T>G	ENST00000405093.3	-	28	4024	c.3954A>C	c.(3952-3954)aaA>aaC	p.K1318N	MYH6_ENST00000356287.3_Missense_Mutation_p.K1318N	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1318					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCAGCTGCCTTTTGAGGTCCT	0.607000													16	124					0	0	0.175082	0	0
PPRC1	23082	broad.mit.edu	37	10	103909067	103909067	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103909067G>C	ENST00000278070.2	+	13	4911	c.4872G>C	c.(4870-4872)aaG>aaC	p.K1624N	PPRC1_ENST00000413464.2_Missense_Mutation_p.K1360N|PPRC1_ENST00000370012.1_Missense_Mutation_p.K591N	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1624					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AGTTCTGCAAGAGGAGCTATT	0.557000													28	65					0	0	0.368089	0	0
SLC26A9	115019	broad.mit.edu	37	1	205896660	205896660	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:205896660G>C	ENST00000367135.3	-	10	1288	c.1175C>G	c.(1174-1176)tCt>tGt	p.S392C	SLC26A9_ENST00000367134.2_Missense_Mutation_p.S392C|SLC26A9_ENST00000340781.4_Missense_Mutation_p.S392C	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	392						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			CAGAGTGACAGAAAGCGCACA	0.517000													11	45					0	0	0.387290	0	0
SLC22A20	440044	broad.mit.edu	37	11	64981715	64981715	+	RNA	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:64981715C>G	ENST00000525437.1	+	0	405							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						CGTCCACCATCGTGATGGAGG	0.657000													4	12					0	0	0.150653	0	0
LAMA5	3911	broad.mit.edu	37	20	60900379	60900379	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:60900379G>T	ENST00000252999.3	-	41	5588	c.5522C>A	c.(5521-5523)tCa>tAa	p.S1841*		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1841	Laminin EGF-like 16; second part.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACCTGGCATGAGTCCCCCCG	0.677000													9	15					0.000978159	0.00100542	0.387290	1	0
PCDHGA10	56106	broad.mit.edu	37	5	140795020	140795020	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:140795020G>A	ENST00000398610.2	+	1	2278	c.2278G>A	c.(2278-2280)Gag>Aag	p.E760K	PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB6_ENST00000520790.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATTCCCACGAGGTCTCTCT	0.602000													56	107					0	0	0.323286	0	0
GANAB	23193	broad.mit.edu	37	11	62398090	62398090	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62398090C>G	ENST00000346178.4	-	12	1450	c.1435G>C	c.(1435-1437)Gct>Cct	p.A479P	GANAB_ENST00000540933.1_Missense_Mutation_p.A360P|GANAB_ENST00000356638.3_Missense_Mutation_p.A457P|GANAB_ENST00000534779.1_Missense_Mutation_p.A365P	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	457					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						CTCTTAGAAGCCAAGCGCTCA	0.537000													4	45					0	0	0.150653	0	0
FMO5	2330	broad.mit.edu	37	1	146672879	146672879	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:146672879G>C	ENST00000254090.4	-	7	1426	c.1038C>G	c.(1036-1038)gtC>gtG	p.V346V	RP11-337C18.8_ENST00000606757.1_RNA|RP11-337C18.8_ENST00000607149.1_RNA|FMO5_ENST00000441068.2_Silent_p.V346V|FMO5_ENST00000369272.3_Intron|RP11-337C18.10_ENST00000606856.1_RNA	NM_001461.2	NP_001452.2	P49326	FMO5_HUMAN	flavin containing monooxygenase 5	346						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	25	all_hematologic(923;0.0487)					TCTTGTTTTTGACCACTTTGA	0.443000													6	68					0	0	0.248553	0	0
C17orf70	80233	broad.mit.edu	37	17	79517599	79517599	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:79517599C>T	ENST00000537152.1	-	3	993	c.468G>A	c.(466-468)gtG>gtA	p.V156V	C17orf70_ENST00000327787.8_Silent_p.V307V	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	307					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			AGTCACAGTGCACATCCTCGT	0.607000													12	74					0	0	0.146539	0	0
INTS7	25896	broad.mit.edu	37	1	212190334	212190334	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:212190334C>T	ENST00000366994.3	-	4	507	c.403G>A	c.(403-405)Gag>Aag	p.E135K	INTS7_ENST00000366993.3_Missense_Mutation_p.E135K|INTS7_ENST00000440600.2_Missense_Mutation_p.E86K|INTS7_ENST00000366992.3_Missense_Mutation_p.E135K|INTS7_ENST00000469606.1_5'UTR	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	135					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TTCTTCCTCTCAGGAATTATT	0.398000													32	123					0	0	0.312237	0	0
OPN5	221391	broad.mit.edu	37	6	47775996	47775996	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:47775996C>T	ENST00000489301.2	+	5	948	c.863C>T	c.(862-864)tCt>tTt	p.S288F	OPN5_ENST00000244799.4_3'UTR|OPN5_ENST00000393699.2_Missense_Mutation_p.S288F|OPN5_ENST00000371211.2_Missense_Mutation_p.S288F			Q6U736	OPN5_HUMAN	opsin 5	288					phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity	p.S288Y(1)		endometrium(1)|large_intestine(3)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	29						ATACAGCTCTCTGTGGTGCCA	0.453000													25	130					0	0	0.382532	0	0
ABHD16A	7920	broad.mit.edu	37	6	31657862	31657862	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:31657862C>T	ENST00000375842.4	-	11	1279	c.293G>A	c.(292-294)gGa>gAa	p.G98E	XXbac-BPG32J3.20_ENST00000461287.1_3'UTR|ABHD16A_ENST00000440843.2_Missense_Mutation_p.G284E|ABHD16A_ENST00000395952.3_Missense_Mutation_p.G317E|ABHD16A_ENST00000471644.1_5'UTR			O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	317						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						CACCGTGCTTCCAGCAAAGCC	0.542000													8	59					0	0	0.093190	0	0
CASC3	22794	broad.mit.edu	37	17	38297460	38297460	+	Splice_Site	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38297460G>T	ENST00000264645.7	+	2	458	c.232G>T	c.(232-234)Gag>Tag	p.E78*		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	78					mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						TTTCTTTCAGGAGAGTGAAGA	0.403000													59	86					2.6465e-34	3.09809e-34	0.323286	1	0
LPAR3	23566	broad.mit.edu	37	1	85279670	85279670	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:85279670C>G	ENST00000440886.1	-	2	959	c.921G>C	c.(919-921)atG>atC	p.M307I	LPAR3_ENST00000491034.1_5'UTR|LPAR3_ENST00000370611.3_Missense_Mutation_p.M307I			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	307					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						AGCAGCAGATCATCTTCTTCA	0.547000													16	64					0	0	0.189662	0	0
HLCS	3141	broad.mit.edu	37	21	38126702	38126702	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:38126702G>C	ENST00000399120.1	-	12	3256	c.2026C>G	c.(2026-2028)Ctg>Gtg	p.L676V	HLCS_ENST00000336648.4_Missense_Mutation_p.L676V	NM_001242784.1	NP_001229713.1	P50747	BPL1_HUMAN	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	676					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	GCGCTGCCCAGATGGACTTGC	0.557000													12	41					0	0	0.175082	0	0
TMPO	7112	broad.mit.edu	37	12	98927062	98927062	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:98927062G>C	ENST00000266732.4	+	4	1265	c.1027G>C	c.(1027-1029)Gag>Cag	p.E343Q	TMPO_ENST00000393053.2_Intron|TMPO_ENST00000261210.5_Intron|TMPO_ENST00000556029.1_Intron|TMPO_ENST00000343315.5_Intron	NM_003276.2	NP_003267.1	P42167	LAP2B_HUMAN	thymopoietin	249	Binds lamins B.|NAKAP95-binding C.|Nucleoplasmic (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			breast(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						ATTATGTCCTGAGAGGTCCCA	0.418000													27	48					0	0	0.382532	0	0
SH3GLB1	51100	broad.mit.edu	37	1	87208005	87208005	+	Silent	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:87208005C>A	ENST00000370558.4	+	8	1200	c.876C>A	c.(874-876)atC>atA	p.I292I	SH3GLB1_ENST00000535010.1_Silent_p.I192I|SH3GLB1_ENST00000482504.1_Silent_p.I313I	NM_001206651.1|NM_001206653.1|NM_016009.4	NP_001193580.1|NP_001193582.1|NP_057093.1	Q9Y371	SHLB1_HUMAN	SH3-domain GRB2-like endophilin B1	292					anti-apoptosis|filopodium assembly|signal transduction	Golgi membrane|mitochondrial outer membrane	cytoskeletal adaptor activity|protein homodimerization activity|SH3 domain binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|stomach(1)	11		Lung NSC(277;0.209)		all cancers(265;0.0136)|Epithelial(280;0.0414)		GCCTAGTAATCACCTCTCCTT	0.438000													36	47					1.30015e-28	1.51299e-28	0.214465	1	0
TCN1	6947	broad.mit.edu	37	11	59623355	59623355	+	Missense_Mutation	SNP	G	G	C	rs146250932	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:59623355G>C	ENST00000257264.3	-	6	1028	c.924C>G	c.(922-924)tgC>tgG	p.C308W	TCN1_ENST00000532419.1_Intron	NM_001062.3	NP_001053.2	P20061	TCO1_HUMAN	transcobalamin I (vitamin B12 binding protein, R binder family)	308					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAGCAGAGACGCAAGAAGAGT	0.443000													20	66					0	0	0.309145	0	0
BRAP	8315	broad.mit.edu	37	12	112123571	112123571	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:112123571C>G	ENST00000419234.4	-	1	219	c.26G>C	c.(25-27)cGa>cCa	p.R9P		NM_006768.3	NP_006759.3	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	9					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	20						GAGCTCCAATCGGATAACAAC	0.726000													9	12					0	0	0.361761	0	0
CEP63	80254	broad.mit.edu	37	3	134278032	134278032	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:134278032G>A	ENST00000337090.3	+	14	1887	c.1714G>A	c.(1714-1716)Gag>Aag	p.E572K	CEP63_ENST00000332047.5_Intron|CEP63_ENST00000606977.1_Missense_Mutation_p.E572K|CEP63_ENST00000354446.3_Intron|CEP63_ENST00000513612.2_Missense_Mutation_p.E572K|CEP63_ENST00000383229.3_Intron			Q96MT8	CEP63_HUMAN	centrosomal protein 63kDa	572					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						AATAAAGACTGAGCACTACAA	0.433000													56	103					0	0	0.323286	0	0
ADAM11	4185	broad.mit.edu	37	17	42849819	42849819	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:42849819G>C	ENST00000535346.1	+	8	765	c.67G>C	c.(67-69)Gag>Cag	p.E23Q	ADAM11_ENST00000200557.6_Silent_p.L221L			O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11	223					integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Prostate(33;0.0959)				GGCCGAGGCTGAGAAGGAAAA	0.706000													3	7					0	0	0.115264	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687370	68687370	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:68687370G>A	ENST00000361320.4	+	2	1274	c.696G>A	c.(694-696)caG>caA	p.Q232Q	CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.2_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	232						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TCAGCCTTCAGAACCTTTACT	0.453000													31	69					0	0	0.183431	0	0
CCT5	22948	broad.mit.edu	37	5	10258507	10258507	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:10258507G>A	ENST00000280326.4	+	6	1153	c.733G>A	c.(733-735)Gat>Aat	p.D245N	CCT5_ENST00000506600.1_Missense_Mutation_p.D152N|CCT5_ENST00000515390.1_Missense_Mutation_p.D190N|CCT5_ENST00000515676.1_Missense_Mutation_p.D207N|CCT5_ENST00000503026.1_Missense_Mutation_p.D224N	NM_012073.3	NP_036205.1	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	245					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(2)	26						GAAAGTGGAAGATGCGAAGAT	0.408000													17	109					0	0	0.219247	0	0
NLRC4	58484	broad.mit.edu	37	2	32461380	32461380	+	Silent	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:32461380C>A	ENST00000404025.2	-	8	3038	c.2550G>T	c.(2548-2550)ctG>ctT	p.L850L	NLRC4_ENST00000342905.6_Silent_p.L185L|NLRC4_ENST00000360906.5_Silent_p.L850L|NLRC4_ENST00000402280.1_Silent_p.L850L			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	850					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CAAGAATGCTCAGTTTGACCA	0.303000													20	40					7.87624e-14	8.57377e-14	0.264190	1	0
CDCA5	113130	broad.mit.edu	37	11	64846584	64846584	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:64846584C>G	ENST00000275517.3	-	6	926	c.754G>C	c.(754-756)Gaa>Caa	p.E252Q	CDCA5_ENST00000404147.3_Missense_Mutation_p.E307Q	NM_080668.3	NP_542399.1	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	252					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding			large_intestine(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						GCATCTCATTCAACCAGGAGA	0.572000													14	29					0	0	0.219247	0	0
GPR68	8111	broad.mit.edu	37	14	91701248	91701248	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:91701248C>G	ENST00000531499.2	-	2	486	c.147G>C	c.(145-147)caG>caC	p.Q49H	GPR68_ENST00000238699.3_Missense_Mutation_p.Q59H|GPR68_ENST00000535815.1_Missense_Mutation_p.Q49H			Q15743	OGR1_HUMAN	G protein-coupled receptor 68	49					inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|lung(2)|skin(1)|urinary_tract(1)	8		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		GGGCCTTGATCTGCAGGTAGC	0.622000													15	32					0	0	0.219247	0	0
NCOR1P1	149934	broad.mit.edu	37	20	26084296	26084296	+	RNA	SNP	A	A	G	rs61752037	by1000genomes	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:26084296A>G	ENST00000478176.1	-	0	161					NR_003678.1													p.F40F(1)									GTTTGCCTCCAAATGCTGGAT	0.378000													3	55					0	0	0.278610	0	0
CD8A	925	broad.mit.edu	37	2	87017470	87017470	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:87017470G>T	ENST00000409511.2	-	5	1414	c.384C>A	c.(382-384)ttC>ttA	p.F128L	CD8A_ENST00000456996.2_Missense_Mutation_p.F128L|CD8A_ENST00000352580.3_Missense_Mutation_p.F128L|CD8A_ENST00000409781.1_Missense_Mutation_p.F128L|CD8A_ENST00000538832.1_Missense_Mutation_p.F169L|CD8A_ENST00000283635.3_Missense_Mutation_p.F128L	NM_001145873.1	NP_001139345.1	P01732	CD8A_HUMAN	CD8a molecule	128	Ig-like V-type.				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	8						AGACCGGCACGAAGTGGCTGA	0.627000													26	59					3.99451e-17	4.46356e-17	0.382532	1	0
STOML3	161003	broad.mit.edu	37	13	39540963	39540963	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:39540963C>T	ENST00000379631.4	-	7	1219	c.875G>A	c.(874-876)tGa>tAa	p.*292*	STOML3_ENST00000423210.1_Silent_p.*283*	NM_145286.2	NP_660329.1	Q8TAV4	STML3_HUMAN	stomatin (EPB72)-like 3	0						integral to membrane|plasma membrane				breast(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	11		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		AAGAGGACCTCAGGCTTTATT	0.443000													29	59					0	0	0.225048	0	0
MYH3	4621	broad.mit.edu	37	17	10539066	10539066	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:10539066C>T	ENST00000583535.1	-	29	4048	c.3961G>A	c.(3961-3963)Gag>Aag	p.E1321K	MYH3_ENST00000226209.7_Missense_Mutation_p.E1321K	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1321					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TTCTCTTCCTCCAGCTGCCTC	0.428000													52	77					0	0	0.323286	0	0
NFRKB	4798	broad.mit.edu	37	11	129762708	129762708	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:129762708C>G	ENST00000446488.3	-	2	140	c.37G>C	c.(37-39)Gaa>Caa	p.E13Q	NFRKB_ENST00000526940.1_Missense_Mutation_p.E13Q|NFRKB_ENST00000524794.1_Missense_Mutation_p.E26Q|NFRKB_ENST00000524746.1_Missense_Mutation_p.E13Q|NFRKB_ENST00000304521.5_Missense_Mutation_p.E13Q	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	13					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GGACCAAGTTCCAGAGGATCT	0.517000													29	136					0	0	0.410975	0	0
KIAA0586	9786	broad.mit.edu	37	14	58895165	58895165	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:58895165G>C	ENST00000354386.6	+	2	463	c.219G>C	c.(217-219)ttG>ttC	p.L73F	KIAA0586_ENST00000423743.3_Intron|KIAA0586_ENST00000261244.5_Missense_Mutation_p.L61F|KIAA0586_ENST00000556134.1_Missense_Mutation_p.L46F	NM_001244189.1	NP_001231118.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	61										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GGACTAGTTTGAATGGAACAT	0.383000													20	55					0	0	0.309145	0	0
SETDB1	9869	broad.mit.edu	37	1	150923439	150923439	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:150923439G>C	ENST00000271640.5	+	13	2276	c.2086G>C	c.(2086-2088)Gag>Cag	p.E696Q	SETDB1_ENST00000459773.1_Intron|SETDB1_ENST00000368969.4_Missense_Mutation_p.E696Q	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	696					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGTGTCAATGAGATTGACAC	0.468000													16	75					0	0	0.279207	0	0
SLC29A3	55315	broad.mit.edu	37	10	73111520	73111520	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:73111520G>C	ENST00000373189.5	+	4	637	c.585G>C	c.(583-585)atG>atC	p.M195I	SLC29A3_ENST00000469204.1_3'UTR	NM_001174098.1|NM_018344.5	NP_001167569.1|NP_060814.4	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 3	195					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	15						CCTTTCCTATGAGGAACTCCC	0.577000													10	17					0	0	0.119110	0	0
HORMAD1	84072	broad.mit.edu	37	1	150687152	150687152	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:150687152G>A	ENST00000368993.2	-	4	286	c.181C>T	c.(181-183)Ctt>Ttt	p.L61F	HORMAD1_ENST00000368995.4_Intron|HORMAD1_ENST00000361824.2_Missense_Mutation_p.L61F|HORMAD1_ENST00000322343.7_Missense_Mutation_p.L61F|HORMAD1_ENST00000476530.1_5'UTR			Q86X24	HORM1_HUMAN	HORMA domain containing 1	61	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(3)	16	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TTGACACAAAGATCTAAACAC	0.274000													14	59					0	0	0.189662	0	0
C18orf25	147339	broad.mit.edu	37	18	43842948	43842948	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:43842948C>T	ENST00000282059.6	+	5	1453	c.1079C>T	c.(1078-1080)tCg>tTg	p.S360L	C18orf25_ENST00000321319.6_Missense_Mutation_p.S299L	NM_145055.3	NP_659492	Q96B23	CR025_HUMAN	chromosome 18 open reading frame 25	360										central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	11						AAGCATGGCTCGGGCACGCAG	0.493000													19	113					0	0	0.324025	0	0
ZNF555	148254	broad.mit.edu	37	19	2852858	2852858	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:2852858C>A	ENST00000334241.4	+	4	933	c.795C>A	c.(793-795)ttC>ttA	p.F265L	ZNF555_ENST00000591539.1_Missense_Mutation_p.F264L|AC006130.3_ENST00000589365.1_RNA	NM_001172775.1|NM_152791.4	NP_001166246.1|NP_690004.4	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)|urinary_tract(4)	23				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAAGCTTTCAGTTATTCCT	0.408000													9	50					9.70103e-10	1.03501e-09	0.361761	1	0
RIN2	54453	broad.mit.edu	37	20	19977329	19977329	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:19977329A>G	ENST00000255006.6	+	11	2503	c.2354A>G	c.(2353-2355)tAt>tGt	p.Y785C	RIN2_ENST00000484638.1_3'UTR|RIN2_ENST00000440354.2_Missense_Mutation_p.Y303C	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	736					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						TCAGGAGGCTATTACTTGACA	0.498000													15	44					0	0	0.146539	0	0
EHMT1	79813	broad.mit.edu	37	9	140729270	140729270	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140729270C>T	ENST00000460843.1	+	27	3789	c.3762C>T	c.(3760-3762)ttC>ttT	p.F1254F		NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1254					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GCAAGCTCTTCAGCTGCCGCT	0.672000													14	16					0	0	0.160694	0	0
PIGQ	9091	broad.mit.edu	37	16	624461	624461	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:624461C>T	ENST00000321878.5	+	2	546	c.387C>T	c.(385-387)atC>atT	p.I129I	PIGQ_ENST00000409527.2_Silent_p.I129I|PIGQ_ENST00000026218.5_Silent_p.I129I|PIGQ_ENST00000470411.2_Silent_p.I129I	NM_004204.3	NP_004195.2	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Q	129					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(780;0.00335)				TCATGCTCATCTTCTATGACC	0.692000													6	12					0	0	0.278610	0	0
XPO4	64328	broad.mit.edu	37	13	21442798	21442798	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:21442798C>G	ENST00000400602.2	-	2	147	c.112G>C	c.(112-114)Gag>Cag	p.E38Q	XPO4_ENST00000490513.1_5'UTR|XPO4_ENST00000255305.6_Missense_Mutation_p.E38Q	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	38					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		AATATGTGCTCTGCATGCTGG	0.323000													54	121					0	0	0.323286	0	0
JADE2	23338	broad.mit.edu	37	5	133914845	133914845	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:133914845G>A	ENST00000395003.1	+	11	2390	c.2211G>A	c.(2209-2211)gaG>gaA	p.E737E	PHF15_ENST00000282605.4_Silent_p.E781E|PHF15_ENST00000402835.1_3'UTR|PHF15_ENST00000361895.2_Silent_p.E738E	NM_015288.4	NP_056103.4	Q9NQC1	JADE2_HUMAN		737					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTGTGGCTGAGAGGCCCAAGG	0.622000													9	62					0	0	0.361761	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67218811	67218811	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67218811G>A	ENST00000314586.6	-	12	2139	c.1899C>T	c.(1897-1899)ctC>ctT	p.L633L		NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	633					exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						TCACCAAACTGAGGAAAAGCT	0.687000													3	22					0	0	0.115264	0	0
OR2A25	392138	broad.mit.edu	37	7	143771967	143771967	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:143771967C>T	ENST00000408898.2	+	1	693	c.655C>T	c.(655-657)Cat>Tat	p.H219Y		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	219					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					ATCTTATGTTCATATTCTATG	0.483000													25	60					0	0	0.294199	0	0
TLR8	51311	broad.mit.edu	37	X	12938564	12938564	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:12938564C>G	ENST00000218032.6	+	2	1492	c.1405C>G	c.(1405-1407)Cat>Gat	p.H469D	TLR8_ENST00000311912.5_Missense_Mutation_p.H487D	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	469					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						GAACTTTTATCATTTCACCCG	0.398000													22	38					0	0	0.368089	0	0
CSRNP3	80034	broad.mit.edu	37	2	166514277	166514277	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:166514277C>G	ENST00000314499.7	+	5	531	c.155C>G	c.(154-156)tCc>tGc	p.S52C	CSRNP3_ENST00000342316.4_Missense_Mutation_p.S52C|CSRNP3_ENST00000409420.1_Missense_Mutation_p.S84C	NM_001172173.1	NP_001165644.1	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	52	Ser-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(3)|skin(2)	33						TCAGCTTCCTCCATTCTCAAA	0.443000													31	85					0	0	0.268233	0	0
DDR1	780	broad.mit.edu	37	6	30865172	30865172	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:30865172G>C	ENST00000324771.8	+	17	2562	c.2014G>C	c.(2014-2016)Gag>Cag	p.E672Q	DDR1_ENST00000446312.1_3'UTR|DDR1_ENST00000452441.1_Missense_Mutation_p.E672Q|DDR1_ENST00000376568.3_Missense_Mutation_p.E672Q|DDR1_ENST00000508312.1_Missense_Mutation_p.E653Q|DDR1_ENST00000376567.2_Missense_Mutation_p.E635Q|DDR1_ENST00000361741.4_Missense_Mutation_p.E339Q|DDR1_ENST00000376570.4_Missense_Mutation_p.E635Q|DDR1_ENST00000454612.2_Missense_Mutation_p.E635Q|DDR1_ENST00000376569.3_Missense_Mutation_p.E635Q|DDR1_ENST00000418800.2_Missense_Mutation_p.E635Q|DDR1_ENST00000513240.1_Missense_Mutation_p.E678Q|DDR1_ENST00000376575.3_Missense_Mutation_p.E678Q			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	672	Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	TTTCCTGAAAGAGGTGAAGAT	0.587000													16	58					0	0	0.219247	0	0
MALAT1	378938	broad.mit.edu	37	11	65272949	65272949	+	RNA	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65272949G>T	ENST00000534336.1	+	0	7717					NR_002819.2																						GGGAAAGGGGGAAAGCGGGCA	0.488000													20	70					4.26978e-12	4.60543e-12	0.279207	1	0
CREB5	9586	broad.mit.edu	37	7	28534602	28534602	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:28534602G>C	ENST00000357727.2	+	3	544	c.154G>C	c.(154-156)Gac>Cac	p.D52H	CREB5_ENST00000396300.2_Missense_Mutation_p.D45H|CREB5_ENST00000396299.2_Missense_Mutation_p.D19H|CREB5_ENST00000409603.1_Missense_Mutation_p.D19H	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	52					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						AATAAAAACAGACAATATGTT	0.408000													23	42					0	0	0.294199	0	0
CC2D1B	200014	broad.mit.edu	37	1	52825538	52825538	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:52825538C>G	ENST00000371586.2	-	8	919	c.781G>C	c.(781-783)Gag>Cag	p.E261Q	CC2D1B_ENST00000284376.3_Missense_Mutation_p.E261Q|CC2D1B_ENST00000460261.1_Intron|CC2D1B_ENST00000438831.1_5'UTR	NM_032449.2	NP_115825.1	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	261	Pro-rich.									breast(1)|large_intestine(6)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	27						AGGCTGGTCTCAGGTTGGGAG	0.572000													3	19					0	0	0.150653	0	0
DNAH5	1767	broad.mit.edu	37	5	13708301	13708301	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:13708301G>A	ENST00000265104.4	-	76	13373	c.13269C>T	c.(13267-13269)atC>atT	p.I4423I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4423					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTTCGCTCATGATGATGGTGC	0.458000									Kartagener syndrome				73	198					0	0	0.323286	0	0
NES	10763	broad.mit.edu	37	1	156640696	156640696	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156640696G>A	ENST00000368223.3	-	4	3416	c.3284C>T	c.(3283-3285)gCg>gTg	p.A1095V		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1095	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCAGCTCCCGCAGCAGACTC	0.662000													17	44					0	0	0.160694	0	0
DCP1B	196513	broad.mit.edu	37	12	2061674	2061674	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:2061674G>A	ENST00000280665.6	-	7	1511	c.1432C>T	c.(1432-1434)Cct>Tct	p.P478S	DCP1B_ENST00000540622.1_Missense_Mutation_p.P352S|DCP1B_ENST00000397173.4_Missense_Mutation_p.P376S	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	478					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			GCGAGCACAGGAAACTTAGCG	0.512000													17	35					0	0	0.160694	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369339.3_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	95					0	0	0.150653	0	0
PCDH12	51294	broad.mit.edu	37	5	141336269	141336269	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:141336269G>A	ENST00000231484.3	-	1	2358	c.1148C>T	c.(1147-1149)tCa>tTa	p.S383L		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	383	Cadherin 4.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGTGTCCTGAATCCAAGTC	0.507000													20	94					0	0	0.264190	0	0
LCTL	197021	broad.mit.edu	37	15	66845384	66845384	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:66845384G>T	ENST00000341509.5	-	9	1266	c.1135C>A	c.(1135-1137)Ctg>Atg	p.L379M	LCTL_ENST00000537670.1_Missense_Mutation_p.L206M	NM_207338.2	NP_997221.2	Q6UWM7	LCTL_HUMAN	lactase-like	379					carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TTAGACCCCAGATCTGGCCAG	0.493000													16	100					4.96729e-08	5.25215e-08	0.204396	1	0
ZNF547	284306	broad.mit.edu	37	19	57888951	57888951	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:57888951C>G	ENST00000282282.3	+	4	757	c.607C>G	c.(607-609)Cag>Gag	p.Q203E	AC003002.4_ENST00000597658.1_Intron	NM_173631.2	NP_775902.2	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAATAGACATCAGAGAACTCA	0.418000													28	39					0	0	0.183431	0	0
UTP20	27340	broad.mit.edu	37	12	101682793	101682793	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:101682793G>C	ENST00000261637.4	+	6	745	c.571G>C	c.(571-573)Gaa>Caa	p.E191Q		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	191					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						TTTTGCTGCTGAAAGTTTTAC	0.328000													8	29					0	0	0.335167	0	0
TP53BP2	7159	broad.mit.edu	37	1	223983678	223983678	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:223983678C>T	ENST00000391878.2	-	14	2944	c.2176G>A	c.(2176-2178)Gaa>Aaa	p.E726K	TP53BP2_ENST00000391879.2_Missense_Mutation_p.E88K|TP53BP2_ENST00000498843.1_5'UTR|TP53BP2_ENST00000343537.7_Missense_Mutation_p.E855K	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	849					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		TTTGGTTCTTCTGGGTTATTC	0.547000													15	89					0	0	0.189662	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													5	248					0	0	0.184627	0	0
SOD1	6647	broad.mit.edu	37	21	33039670	33039670	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:33039670C>T	ENST00000270142.6	+	4	487	c.339C>T	c.(337-339)atC>atT	p.I113I	SOD1_ENST00000470944.1_3'UTR|SOD1_ENST00000389995.4_Silent_p.I94I	NM_000454.4	NP_000445.1	P00441	SODC_HUMAN	superoxide dismutase 1, soluble	113			I -> M (in ALS1).|I -> T (in ALS1).		activation of MAPK activity|auditory receptor cell stereocilium organization|cell aging|cellular iron ion homeostasis|DNA fragmentation involved in apoptotic nuclear change|double-strand break repair|embryo implantation|glutathione metabolic process|heart contraction|hydrogen peroxide biosynthetic process|locomotory behavior|muscle cell homeostasis|myeloid cell homeostasis|negative regulation of cholesterol biosynthetic process|negative regulation of neuron apoptosis|neurofilament cytoskeleton organization|ovarian follicle development|peripheral nervous system myelin maintenance|placenta development|platelet activation|platelet degranulation|positive regulation of cytokine production|regulation of blood pressure|regulation of mitochondrial membrane potential|regulation of multicellular organism growth|regulation of organ growth|regulation of T cell differentiation in thymus|relaxation of vascular smooth muscle|removal of superoxide radicals|response to axon injury|response to drug|response to ethanol|response to heat|response to hydrogen peroxide|retina homeostasis|sensory perception of sound|spermatogenesis|thymus development	cytoplasmic vesicle|cytosol|dendrite cytoplasm|extracellular matrix|extracellular space|mitochondrial matrix|neuronal cell body|nucleus|peroxisome|protein complex	chaperone binding|copper ion binding|protein homodimerization activity|protein phosphatase 2B binding|superoxide dismutase activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)	4						ACCATTGCATCATTGGCCGCA	0.428000													21	165					0	0	0.353513	0	0
PAQR6	79957	broad.mit.edu	37	1	156215947	156215947	+	Translation_Start_Site	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156215947G>A	ENST00000335852.1	-	0	308				PAQR6_ENST00000356983.2_De_novo_Start_InFrame|PAQR6_ENST00000492619.1_5'UTR|PAQR6_ENST00000292291.5_Missense_Mutation_p.T49M|PAQR6_ENST00000368270.1_Missense_Mutation_p.T25M|PAQR6_ENST00000540423.1_Missense_Mutation_p.T46M	NM_024897.3	NP_079173.2	Q6TCH4	PAQR6_HUMAN	progestin and adipoQ receptor family member VI							integral to membrane	receptor activity			lung(4)|ovary(1)	5	Hepatocellular(266;0.158)					GATGTTGACCGTCTCGTTGGT	0.647000													23	43					0	0	0.309145	0	0
BARHL2	343472	broad.mit.edu	37	1	91182500	91182500	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:91182500G>A	ENST00000370445.4	-	1	294	c.253C>T	c.(253-255)Cat>Tat	p.H85Y		NM_020063.1	NP_064447.1	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	85						nucleus	sequence-specific DNA binding			cervix(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		AGGTGGTGATGATGCTGGGTC	0.657000													10	16					0	0	0.361761	0	0
MC4R	4160	broad.mit.edu	37	18	58038833	58038833	+	Silent	SNP	C	C	T	rs13447339		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:58038833C>T	ENST00000299766.3	-	1	1168	c.750G>A	c.(748-750)ctG>ctA	p.L250L		NM_005912.2	NP_005903.2	P32245	MC4R_HUMAN	melanocortin 4 receptor	250					feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(73;0.0946)				AGACGCCAATCAGGATGGTCA	0.498000													23	29					0	0	0.324025	0	0
CELSR3	1951	broad.mit.edu	37	3	48694197	48694197	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48694197G>C	ENST00000544264.1	-	2	4613	c.4333C>G	c.(4333-4335)Cgc>Ggc	p.R1445G	CELSR3_ENST00000164024.4_Missense_Mutation_p.R1445G			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	1445	EGF-like 2; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCGCCGTTGCGACATGGGTTG	0.711000													2	8					0	0	0.115264	0	0
ACIN1	22985	broad.mit.edu	37	14	23530572	23530572	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23530572G>C	ENST00000262710.1	-	17	3860	c.3533C>G	c.(3532-3534)tCa>tGa	p.S1178*	ACIN1_ENST00000555053.1_Nonsense_Mutation_p.S1165*|ACIN1_ENST00000457657.1_Nonsense_Mutation_p.S1138*|ACIN1_ENST00000338631.6_Nonsense_Mutation_p.S451*|ACIN1_ENST00000605057.1_Nonsense_Mutation_p.S1120*|ACIN1_ENST00000557515.1_Nonsense_Mutation_p.S419*|ACIN1_ENST00000397341.3_Nonsense_Mutation_p.S420*|ACIN1_ENST00000357481.2_Nonsense_Mutation_p.S420*	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1178	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ACGGGACCTTGATCGGGAACG	0.567000													33	105					0	0	0.235728	0	0
GPLD1	2822	broad.mit.edu	37	6	24486344	24486344	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:24486344C>T	ENST00000230036.1	-	2	222	c.112G>A	c.(112-114)Gag>Aag	p.E38K	GPLD1_ENST00000474784.1_5'UTR	NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	38						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						TGAAGAAACTCCAGAGCTCTG	0.323000													20	129					0	0	0.382532	0	0
HCST	10870	broad.mit.edu	37	19	36394703	36394703	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:36394703C>G	ENST00000246551.4	+	3	253	c.139C>G	c.(139-141)Ctg>Gtg	p.L47V	HCST_ENST00000437550.2_Missense_Mutation_p.L47V			Q9UBK5	HCST_HUMAN	hematopoietic cell signal transducer	47					regulation of immune response	integral to membrane|plasma membrane				lung(4)	4	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTCCCTCTCTCTGCCGCTCCT	0.682000													5	32					0	0	0.278610	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6534204	6534204	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:6534204C>G	ENST00000377748.1	-	8	1188	c.691G>C	c.(691-693)Gag>Cag	p.E231Q	PLEKHG5_ENST00000377740.3_Missense_Mutation_p.E231Q|PLEKHG5_ENST00000340850.5_Missense_Mutation_p.E154Q|PLEKHG5_ENST00000544978.1_Missense_Mutation_p.E154Q|PLEKHG5_ENST00000377732.1_Missense_Mutation_p.E191Q|PLEKHG5_ENST00000400915.3_Missense_Mutation_p.E210Q|PLEKHG5_ENST00000377728.3_Missense_Mutation_p.E154Q|PLEKHG5_ENST00000535355.1_Missense_Mutation_p.E223Q|PLEKHG5_ENST00000377737.2_Missense_Mutation_p.E154Q|PLEKHG5_ENST00000400913.1_Missense_Mutation_p.E154Q|PLEKHG5_ENST00000377725.1_Missense_Mutation_p.E154Q|PLEKHG5_ENST00000537245.1_Missense_Mutation_p.E233Q	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	210					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		ACCTTGCCCTCATCTCCAGGC	0.677000													9	35					0	0	0.093190	0	0
SLC23A3	151295	broad.mit.edu	37	2	220034633	220034633	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:220034633G>T	ENST00000455516.2	-	1	121	c.74C>A	c.(73-75)cCa>cAa	p.P25Q	SLC23A3_ENST00000396775.3_5'UTR|SLC23A3_ENST00000295738.7_Missense_Mutation_p.P25Q|SLC23A3_ENST00000409878.3_Missense_Mutation_p.P25Q	NM_001144890.1	NP_001138362.1	Q6PIS1	S23A3_HUMAN	solute carrier family 23, member 3	25					transmembrane transport	integral to membrane	protein binding|transporter activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	11		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGAGCAGGTGGAGGCAAGGG	0.612000													4	35					0.150653	0.151682	0.150653	1	0
IGDCC4	57722	broad.mit.edu	37	15	65680830	65680830	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:65680830G>C	ENST00000352385.2	-	16	3011	c.2802C>G	c.(2800-2802)ttC>ttG	p.F934L		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	934	Fibronectin type-III 5.					integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						GCAGGCGGGAGAAAGGCCCAG	0.602000													59	169					0	0	0.323286	0	0
PTPN13	5783	broad.mit.edu	37	4	87622590	87622590	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:87622590C>G	ENST00000436978.1	+	7	1311	c.831C>G	c.(829-831)ttC>ttG	p.F277L	PTPN13_ENST00000316707.6_Missense_Mutation_p.F277L|PTPN13_ENST00000411767.2_Missense_Mutation_p.F277L|PTPN13_ENST00000511467.1_Missense_Mutation_p.F277L|PTPN13_ENST00000427191.2_Missense_Mutation_p.F277L	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	277						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CTTACCAGTTCAAAACTAGTG	0.393000													7	11					0	0	0.307466	0	0
NOP16	51491	broad.mit.edu	37	5	175811345	175811345	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:175811345G>C	ENST00000389158.5	-	5	859	c.424C>G	c.(424-426)Caa>Gaa	p.Q142E	NOP16_ENST00000507413.1_Intron|NOP16_ENST00000510123.1_Intron			Q9Y3C1	NOP16_HUMAN	NOP16 nucleolar protein	142						nucleolus				central_nervous_system(1)|endometrium(2)|lung(4)|ovary(1)	8						GGGGTATCTTGATAGTAATTC	0.448000													6	45					0	0	0.217242	0	0
TSGA13	114960	broad.mit.edu	37	7	130353957	130353957	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:130353957G>T	ENST00000456951.1	-	9	1576	c.725C>A	c.(724-726)tCg>tAg	p.S242*	TSGA13_ENST00000356588.3_Nonsense_Mutation_p.S242*			Q96PP4	TSG13_HUMAN	testis specific, 13	242										endometrium(1)|kidney(3)|large_intestine(3)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	18	Melanoma(18;0.0435)					TTCCAAGAGCGATGCGAGTGT	0.582000													32	72					3.86903e-22	4.45845e-22	0.173368	1	0
GTF2F1	2962	broad.mit.edu	37	19	6392882	6392882	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:6392882G>A	ENST00000394456.5	-	2	509	c.45C>T	c.(43-45)gtC>gtT	p.V15V		NM_002096.2	NP_002087.2	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1, 74kDa	15					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)	16						GAACTCGAACGACGTATTCAG	0.587000											OREG0025199	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	186					0	0	0.323286	0	0
PTPRB	5787	broad.mit.edu	37	12	70956762	70956762	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:70956762G>C	ENST00000334414.6	-	16	4074	c.4030C>G	c.(4030-4032)Ctc>Gtc	p.L1344V	PTPRB_ENST00000550857.1_Missense_Mutation_p.L1036V|PTPRB_ENST00000451516.2_Missense_Mutation_p.L1036V|PTPRB_ENST00000261266.5_Missense_Mutation_p.L1126V|PTPRB_ENST00000550358.1_Missense_Mutation_p.L1256V|PTPRB_ENST00000538708.1_Missense_Mutation_p.L1036V|PTPRB_ENST00000551525.1_Missense_Mutation_p.L1343V	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1126	Fibronectin type-III 15.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTCTCCTGGAGATTCCCATCT	0.512000													8	60					0	0	0.307466	0	0
SIK2	23235	broad.mit.edu	37	11	111594445	111594445	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:111594445C>G	ENST00000304987.3	+	15	2546	c.2373C>G	c.(2371-2373)ctC>ctG	p.L791L		NM_015191.1	NP_056006.1	Q9H0K1	SIK2_HUMAN	salt-inducible kinase 2	791					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	30						GCCCTTTCCTCAGCCAGTACC	0.662000													136	297					0	0	0.323286	0	0
SHANK2	22941	broad.mit.edu	37	11	70332669	70332669	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:70332669G>A	ENST00000338508.4	-	32	3731	c.3732C>T	c.(3730-3732)ctC>ctT	p.L1244L	SHANK2_ENST00000409161.1_Silent_p.L647L|SHANK2_ENST00000423696.2_Silent_p.L864L|SHANK2_ENST00000449833.2_Silent_p.L648L			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	864					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GAGGTTTGTTGAGGTCGGCCT	0.632000													8	97					0	0	0.361761	0	0
MLLT10	8028	broad.mit.edu	37	10	21962735	21962735	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:21962735C>G	ENST00000377072.3	+	11	1856	c.1508C>G	c.(1507-1509)tCt>tGt	p.S503C	MLLT10_ENST00000377059.3_Missense_Mutation_p.S503C|MLLT10_ENST00000446906.2_Missense_Mutation_p.S503C|MLLT10_ENST00000307729.7_Missense_Mutation_p.S503C	NM_004641.3	NP_004632.1	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	503	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						CCAACATCATCTGTAGCATCA	0.433000			T	"""MLL, PICALM, CDK6"""	AL								27	76					0	0	0.368089	0	0
CALHM2	51063	broad.mit.edu	37	10	105207266	105207266	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:105207266G>C	ENST00000260743.5	-	4	1138	c.615C>G	c.(613-615)ctC>ctG	p.L205L	CALHM2_ENST00000369788.3_Silent_p.L205L	NM_015916.4	NP_057000.2	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	205						integral to membrane				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)|skin(1)	11						AGTAATGCTTGAGGCACTTGG	0.617000													3	38					0	0	0.150653	0	0
FAM134C	162427	broad.mit.edu	37	17	40733844	40733844	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:40733844G>C	ENST00000309428.5	-	9	1447	c.1388C>G	c.(1387-1389)tCt>tGt	p.S463C	FAM134C_ENST00000543197.1_Missense_Mutation_p.S268C|FAM134C_ENST00000585894.1_Missense_Mutation_p.S366C	NM_178126.3	NP_835227.1	Q86VR2	F134C_HUMAN	family with sequence similarity 134, member C	463						integral to membrane				endometrium(1)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	11		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		GTGGCTCCTAGAACTGGCAGG	0.547000													16	34					0	0	0.189662	0	0
NWD1	284434	broad.mit.edu	37	19	16860125	16860125	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:16860125C>G	ENST00000524140.2	+	6	1090	c.672C>G	c.(670-672)ctC>ctG	p.L224L	NWD1_ENST00000552788.1_Silent_p.L224L|NWD1_ENST00000523826.1_Silent_p.L18L|NWD1_ENST00000339803.6_Silent_p.L89L|NWD1_ENST00000549814.1_Silent_p.L224L|NWD1_ENST00000379808.3_Silent_p.L224L	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	224							ATP binding	p.L224L(1)|p.L89L(1)		NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AGAACCTTCTCAGCAGCCTCA	0.587000													12	64					0	0	0.093190	0	0
RPTN	126638	broad.mit.edu	37	1	152128385	152128388	+	Frame_Shift_Del	DEL	TGTC	TGTC	-			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:152128385_152128388delTGTC	ENST00000316073.3	-	3	1251_1254	c.1187_1190delGACA	c.(1186-1191)agacaafs	p.RQ396fs		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	396	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						ACTTTGGTCTTGTCTGTCTGTCTG	0.505													8	1501	---	---	---	---					
USP4	7375	broad.mit.edu	37	3	49362440	49362441	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49362440_49362441insA	ENST00000351842.4	-	5	527_528	c.519_520insT	c.(517-522)ttcaacfs	p.N174fs	USP4_ENST00000415188.1_Frame_Shift_Ins_p.N174fs|USP4_ENST00000416417.1_Frame_Shift_Ins_p.N174fs|USP4_ENST00000265560.4_Frame_Shift_Ins_p.N174fs	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	174					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GCAGGGATGTTGAATAGCTTCC	0.500													52	162	---	---	---	---					
PAXIP1	22976	broad.mit.edu	37	7	154760267	154760269	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:154760267_154760269delCTG	ENST00000404141.1	-	7	1796_1798	c.1642_1644delCAG	c.(1642-1644)cagdel	p.Q548del	PAXIP1_ENST00000473219.1_5'UTR|PAXIP1_ENST00000397192.1_In_Frame_Del_p.Q548del			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	548	Gln-rich.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		GACTTTGCATctgctgctgctgc	0.626													4	4	---	---	---	---					
SUPT5H	6829	broad.mit.edu	37	19	39962359	39962359	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:39962359delG	ENST00000599117.1	+	21	2306	c.1939delG	c.(1939-1941)gggfs	p.G648fs	SUPT5H_ENST00000359191.6_Frame_Shift_Del_p.G644fs|SUPT5H_ENST00000432763.2_Frame_Shift_Del_p.G648fs|SUPT5H_ENST00000402194.2_Frame_Shift_Del_p.G644fs|SUPT5H_ENST00000598725.1_Frame_Shift_Del_p.G648fs			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	648					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGTGCTGGCTGGGGGCTCAAA	0.587													15	40	---	---	---	---					
