Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DUXA	503835	broad.mit.edu	37	19	57672085	57672085	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:57672085G>C	ENST00000554048.2	-	2	105	c.106C>G	c.(106-108)Caa>Gaa	p.Q36E		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	36						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.Q36E(1)		breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		TAAGGCTTTTGATTGAAGGTA	0.368000													18	47					0	0	1	0	0
TNFRSF12A	51330	broad.mit.edu	37	16	3071909	3071909	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:3071909G>A	ENST00000575124.1	+	3	658	c.635G>A	c.(634-636)cGg>cAg	p.R212Q	TNFRSF12A_ENST00000341627.5_3'UTR|TNFRSF12A_ENST00000326577.4_3'UTR|TNFRSF12A_ENST00000573001.1_3'UTR			Q9NP84	TNR12_HUMAN	tumor necrosis factor receptor superfamily, member 12A	106					angiogenesis|apoptosis	integral to membrane	receptor activity			lung(1)|skin(1)	2						TCCCAGACGCGGCGGGAGCCA	0.632000													4	10					0	0	1	0	0
CTSF	8722	broad.mit.edu	37	11	66332359	66332359	+	Splice_Site	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:66332359C>G	ENST00000310325.5	-	9	1273	c.1164G>C	c.(1162-1164)caG>caC	p.Q388H		NM_003793.3	NP_003784.2	Q9UBX1	CATF_HUMAN	cathepsin F	388					proteolysis	lysosome	cysteine-type endopeptidase activity			endometrium(1)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CTCACTCACTCTGCTCGTTCT	0.607000													40	14					0	0	1	0	0
PSKH1	5681	broad.mit.edu	37	16	67942658	67942658	+	Silent	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:67942658C>G	ENST00000291041.5	+	2	176	c.6C>G	c.(4-6)ggC>ggG	p.G2G		NM_006742.2	NP_006733.1	P11801	KPSH1_HUMAN	protein serine kinase H1	2						endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|nuclear speck|plasma membrane	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(7)|pancreas(1)	12		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0044)|Epithelial(162;0.0197)|all cancers(182;0.128)		CCGTGATGGGCTGTGGGACAA	0.577000													12	17					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169814519	169814519	+	Silent	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:169814519C>G	ENST00000263817.6	-	19	2422	c.2298G>C	c.(2296-2298)ggG>ggC	p.G766G		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	766	ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GTGTGACTGTCCCGTTCACAG	0.453000													9	19					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13240691	13240691	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:13240691G>A	ENST00000378694.1	+	15	2197	c.2122G>A	c.(2122-2124)Gag>Aag	p.E708K	MCM10_ENST00000484800.2_Missense_Mutation_p.E709K|MCM10_ENST00000378714.3_Missense_Mutation_p.E708K			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	709					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						TGCCCTAGCTGAGGATGAATT	0.463000													20	27					0	0	1	0	0
SRSF4	6429	broad.mit.edu	37	1	29475466	29475466	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:29475466C>T	ENST00000373795.4	-	6	1175	c.941G>A	c.(940-942)cGa>cAa	p.R314Q	SRSF4_ENST00000546138.1_3'UTR|SRSF4_ENST00000466448.1_5'UTR	NM_005626.4	NP_005617.2	Q08170	SRSF4_HUMAN	serine/arginine-rich splicing factor 4	314	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(1)	27						cacactccctcgcttctcctc	0.622000													35	31					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42355858	42355858	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:42355858C>T	ENST00000554171.1	+	5	2462	c.30C>T	c.(28-30)ctC>ctT	p.L10L	LRFN5_ENST00000298119.4_Silent_p.L10L|LRFN5_ENST00000554120.1_Silent_p.L10L			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	10						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		ATCTGTTTCTCATTGGCATAG	0.373000										HNSCC(30;0.082)			14	25					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35713028	35713028	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr9:35713028C>T	ENST00000314888.9	-	27	3718	c.3365G>A	c.(3364-3366)cGg>cAg	p.R1122Q	TLN1_ENST00000540444.1_Missense_Mutation_p.R1122Q	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1122					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGCCACATCCCGAGCTGCAAT	0.592000													7	10					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15364547	15364547	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:15364547G>A	ENST00000360016.5	-	12	2495	c.2206C>T	c.(2206-2208)Cac>Tac	p.H736Y	BRD4_ENST00000371835.4_Intron|BRD4_ENST00000263377.2_Intron			O60885	BRD4_HUMAN	bromodomain containing 4	269					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			ACGTGACTGTGATACGGGGAA	0.622000			T	C15orf55	lethal midline carcinoma of young people								25	17					0	0	1	0	0
RBP2	5948	broad.mit.edu	37	3	139195266	139195266	+	Silent	SNP	C	C	T	rs111406295		TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:139195266C>T	ENST00000232217.2	-	1	92	c.36G>A	c.(34-36)gaG>gaA	p.E12E	RP11-319G6.1_ENST00000515247.1_RNA	NM_004164.2	NP_004155.2	P50120	RET2_HUMAN	retinol binding protein 2, cellular	12					epidermis development|retinoid metabolic process|steroid metabolic process|vitamin A metabolic process	cytosol	retinal binding|retinol binding|transporter activity			breast(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12					Vitamin A(DB00162)	TTTCATTACTCTCCATCTCCC	0.562000													37	22					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240072230	240072230	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:240072230C>T	ENST00000255380.4	+	5	2258	c.1479C>T	c.(1477-1479)ctC>ctT	p.L493L		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	493					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CCCAGACCCTCAGTGCGATCT	0.498000													42	40					0	0	1	0	0
MARCH7	64844	broad.mit.edu	37	2	160605018	160605018	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:160605018G>C	ENST00000259050.4	+	5	1339	c.1217G>C	c.(1216-1218)aGa>aCa	p.R406T	MARCH7_ENST00000409591.1_Missense_Mutation_p.R368T|MARCH7_ENST00000409175.1_Missense_Mutation_p.R406T|MARCH7_ENST00000539065.1_Missense_Mutation_p.R350T	NM_001282805.1|NM_001282807.1|NM_022826.2	NP_001269734.1|NP_001269736.1|NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase		Ser-rich.						ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						CGAGAGGGAAGAGATGAATCT	0.383000													30	51					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119456784	119456784	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:119456784C>T	ENST00000369429.3	-	6	889	c.880G>A	c.(880-882)Gac>Aac	p.D294N	TBX15_ENST00000207157.3_Missense_Mutation_p.D188N			Q96SF7	TBX15_HUMAN	T-box 15	294						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GGGTTTCGGTCAATTTTTAAT	0.338000													17	74					0	0	1	0	0
IHH	3549	broad.mit.edu	37	2	219920433	219920433	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:219920433G>A	ENST00000295731.6	-	3	731	c.732C>T	c.(730-732)ctC>ctT	p.L244L		NM_002181.3	NP_002172.2	Q14623	IHH_HUMAN	indian hedgehog						cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCAGGAAAATGAGCACATCGC	0.667000													7	21					0	0	1	0	0
PALM2	114299	broad.mit.edu	37	9	112705326	112705326	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr9:112705326C>G	ENST00000448454.2	+	8	863	c.863C>G	c.(862-864)tCt>tGt	p.S288C	AKAP2_ENST00000555236.1_Intron|PALM2-AKAP2_ENST00000302798.7_Intron|PALM2_ENST00000483909.1_Missense_Mutation_p.S252C|AKAP2_ENST00000510514.5_Intron|PALM2_ENST00000374531.2_Missense_Mutation_p.S254C|PALM2-AKAP2_ENST00000374530.3_Intron|PALM2_ENST00000314527.4_Missense_Mutation_p.S286C					paralemmin 2											breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	18						AAAGACCATTCTTCCGGGAAC	0.527000													9	11					0	0	1	0	0
MCCC1	56922	broad.mit.edu	37	3	182751863	182751863	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:182751863G>C	ENST00000492597.1	-	13	1972	c.1270C>G	c.(1270-1272)Caa>Gaa	p.Q424E	MCCC1_ENST00000539926.1_Missense_Mutation_p.Q398E|MCCC1_ENST00000265594.4_Missense_Mutation_p.Q533E|MCCC1_ENST00000489909.1_5'UTR			Q96RQ3	MCCA_HUMAN	methylcrotonoyl-CoA carboxylase 1 (alpha)	533	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(17)|ovary(1)|pancreas(2)|prostate(1)|skin(2)	40	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	GGAGAGAATTGATCTAGAAAA	0.328000													337	73					0	0	1	0	0
SORCS2	57537	broad.mit.edu	37	4	7741955	7741955	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr4:7741955C>T	ENST00000507866.2	+	27	3553	c.3444C>T	c.(3442-3444)atC>atT	p.I1148I	SORCS2_ENST00000329016.9_Silent_p.I991I	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	1148						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						TCCTGAGCATCAACTCCCGAG	0.617000													6	7					0	0	1	0	0
SAFB2	9667	broad.mit.edu	37	19	5616293	5616293	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:5616293C>T	ENST00000252542.4	-	4	657	c.393G>A	c.(391-393)atG>atA	p.M131I		NM_014649.2	NP_055464.1	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		CTAGCACACTCATGTCCATCA	0.488000													10	23					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29585261	29585261	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:29585261C>T	ENST00000323874.8	+	3	560	c.450C>T	c.(448-450)gtC>gtT	p.V150V	PTPRU_ENST00000460170.2_Silent_p.V150V|PTPRU_ENST00000428026.2_Silent_p.V150V|PTPRU_ENST00000356870.3_Silent_p.V150V|PTPRU_ENST00000373779.3_Silent_p.V150V|PTPRU_ENST00000345512.3_Silent_p.V150V			Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	150	MAM.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		AGCTGGCTGTCAGCACTTTCT	0.597000													15	37					0	0	1	0	0
INHBE	83729	broad.mit.edu	37	12	57849543	57849543	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:57849543C>T	ENST00000266646.2	+	1	440	c.224C>T	c.(223-225)gCc>gTc	p.A75V	INHBE_ENST00000551553.1_Intron	NM_031479.3	NP_113667.1	P58166	INHBE_HUMAN	inhibin, beta E	75					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	15						CTGACCAGAGCCCTCCGGAGA	0.597000											OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	20					0	0	1	0	0
CDHR5	53841	broad.mit.edu	37	11	617419	617419	+	Missense_Mutation	SNP	C	C	T	rs76054644		TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:617419C>T	ENST00000358353.3	-	16	2792	c.2470G>A	c.(2470-2472)Gag>Aag	p.E824K	CDHR5_ENST00000397542.2_Missense_Mutation_p.E824K|CDHR5_ENST00000349570.7_Missense_Mutation_p.E630K			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	824					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						CCCTCGCCCTCATCGCCGCTG	0.687000													3	12					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155191083	155191083	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr4:155191083T>A	ENST00000357232.4	-	19	5180	c.5181A>T	c.(5179-5181)gaA>gaT	p.E1727D		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GAACTCCATCTTCATTTCCAC	0.343000													34	24					0	0	1	0	0
FIP1L1	81608	broad.mit.edu	37	4	54310244	54310244	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr4:54310244C>G	ENST00000337488.6	+	15	1453	c.1259C>G	c.(1258-1260)tCt>tGt	p.S420C	FIP1L1_ENST00000306932.6_Missense_Mutation_p.S346C|FIP1L1_ENST00000358575.5_Missense_Mutation_p.S414C|FIP1L1_ENST00000507166.1_Intron	NM_030917.3	NP_112179.2	Q6UN15	FIP1_HUMAN	factor interacting with PAPOLA and CPSF1	420					mRNA processing	nucleus	RNA binding			large_intestine(3)|liver(1)|ovary(1)|skin(1)	6			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			GATAGTCGTTCTGCACGTGCA	0.294000			T	PDGFRA	idiopathic hypereosinophilic syndrome								7	80					0	0	1	0	0
MICB	4277	broad.mit.edu	37	6	31474881	31474881	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:31474881C>T	ENST00000252229.6	+	4	775	c.696C>T	c.(694-696)ccC>ccT	p.P232P	MICB_ENST00000538442.1_Silent_p.P200P|MICB_ENST00000399150.3_Silent_p.P189P	NM_005931.3	NP_005922.2	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	232	Ig-like C1-type.				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	13						GCTTCTATCCCCGGAATATCA	0.572000													10	26					0	0	1	0	0
SPINK5	11005	broad.mit.edu	37	5	147506618	147506618	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:147506618C>T	ENST00000359874.3	+	31	3103	c.3030C>T	c.(3028-3030)gaC>gaT	p.D1010D	SPINK5_ENST00000256084.7_Silent_p.D980D	NM_001127698.1	NP_001121170.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	980	Kazal-like 15.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAGGAAGACAGCCCAGACT	0.348000													6	20					0	0	1	0	0
GEMIN4	50628	broad.mit.edu	37	17	649490	649490	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:649490G>A	ENST00000576778.1	-	1	3101	c.1760C>T	c.(1759-1761)tCa>tTa	p.S587L	GEMIN4_ENST00000319004.5_Missense_Mutation_p.S598L			P57678	GEMI4_HUMAN	gem (nuclear organelle) associated protein 4	598					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		AGTGGCAGATGAATTGGGACC	0.512000													57	14					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70549858	70549858	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr13:70549858C>A	ENST00000377844.4	-	2	1333	c.574G>T	c.(574-576)Gtt>Ttt	p.V192F	KLHL1_ENST00000545028.1_Intron	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	192					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GCATGATGAACAGCTTGATAG	0.428000													20	15					1.33834e-09	1.40409e-09	1	1	0
NSUN6	221078	broad.mit.edu	37	10	18905157	18905157	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:18905157C>T	ENST00000377304.4	-	4	795	c.377G>A	c.(376-378)aGa>aAa	p.R126K		NM_182543.2	NP_872349.1	Q8TEA1	NSUN6_HUMAN	NOP2/Sun domain family, member 6	126	PUA.						methyltransferase activity|RNA binding			endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15						ATGGGCTCCTCTTAAAACTGC	0.353000													28	35					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240072073	240072073	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:240072073C>T	ENST00000255380.4	+	5	2101	c.1322C>T	c.(1321-1323)tCt>tTt	p.S441F		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	441					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GCTAAGACTTCTGACGTCAAC	0.542000													12	8					0	0	1	0	0
ZNF346	23567	broad.mit.edu	37	5	176477855	176477855	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:176477855G>A	ENST00000503039.1	+	6	700	c.696G>A	c.(694-696)aaG>aaA	p.K232K	ZNF346_ENST00000511834.1_Silent_p.K223K|ZNF346_ENST00000506693.1_Silent_p.K109K|ZNF346_ENST00000261948.4_Silent_p.K232K|ZNF346_ENST00000503425.1_Silent_p.K175K|ZNF346_ENST00000512315.1_Intron|ZNF346_ENST00000358149.3_Silent_p.K207K			Q9UL40	ZN346_HUMAN	zinc finger protein 346	207						cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	14	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATGTGGGCAAGAAACACAGAA	0.522000													21	28					0	0	1	0	0
UBLCP1	134510	broad.mit.edu	37	5	158710291	158710291	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:158710291C>T	ENST00000296786.6	+	10	1199	c.873C>T	c.(871-873)ctC>ctT	p.L291L		NM_145049.3	NP_659486.2	Q8WVY7	UBCP1_HUMAN	ubiquitin-like domain containing CTD phosphatase 1	291	FCP1 homology.					nucleus	phosphoprotein phosphatase activity			endometrium(1)|kidney(3)|large_intestine(4)|ovary(1)	9	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCAGTACCTCAAGGAGATAG	0.299000													23	55					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89349481	89349481	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:89349481C>G	ENST00000301030.4	-	9	3929	c.3469G>C	c.(3469-3471)Gag>Cag	p.E1157Q	ANKRD11_ENST00000378330.2_Missense_Mutation_p.E1157Q	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1157	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCATAGGCCTCCCGTCCTTCC	0.617000													15	34					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57548274	57548274	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:57548274C>G	ENST00000243077.3	+	8	1483	c.1017C>G	c.(1015-1017)ttC>ttG	p.F339L	LRP1_ENST00000554174.1_Missense_Mutation_p.F339L	NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	339					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AGGTGTTTTTCACTGACTATG	0.537000													15	14					0	0	1	0	0
CCNYL1	151195	broad.mit.edu	37	2	208618339	208618339	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:208618339G>C	ENST00000295414.3	+	10	1208	c.997G>C	c.(997-999)Gac>Cac	p.D333H	CCNYL1_ENST00000468768.1_3'UTR|CCNYL1_ENST00000392209.3_Missense_Mutation_p.D263H|CCNYL1_ENST00000339882.5_Missense_Mutation_p.D282H			Q8N7R7	CCYL1_HUMAN	cyclin Y-like 1	333					regulation of cyclin-dependent protein kinase activity		protein kinase binding			endometrium(1)|large_intestine(1)|lung(3)	5				LUSC - Lung squamous cell carcinoma(261;0.0731)|Epithelial(149;0.139)|Lung(261;0.14)		TGAAGACAAAGACTTGTGTAG	0.403000													39	118					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123071247	123071247	+	Splice_Site	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:123071247G>A	ENST00000333479.7	+	38	3850		c.e38-1		KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1						cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		ATCTTTTGTAGAAAGCAAGAG	0.328000													11	32					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44676662	44676662	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr20:44676662C>T	ENST00000243964.3	+	16	2048	c.1950C>T	c.(1948-1950)ctC>ctT	p.L650L	SLC12A5_ENST00000454036.2_Silent_p.L673L	NM_020708.4	NP_065759.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	673					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GTCTGTCTCTCAGTGCGGCTC	0.607000													8	5					0	0	1	0	0
KCNE4	23704	broad.mit.edu	37	2	223918025	223918025	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:223918025C>T	ENST00000281830.3	+	2	961	c.630C>T	c.(628-630)agC>agT	p.S210S	KCNE4_ENST00000604125.1_Silent_p.S159S|KCNE4_ENST00000488477.2_Intron			Q8WWG9	KCNE4_HUMAN	potassium voltage-gated channel, Isk-related family, member 4	159						integral to membrane	voltage-gated potassium channel activity			large_intestine(2)|lung(5)|ovary(2)|skin(1)	10		Renal(207;0.0183)|Lung NSC(271;0.137)|all_lung(227;0.175)		Epithelial(121;4.48e-11)|all cancers(144;2.88e-08)|Lung(261;0.00688)|LUSC - Lung squamous cell carcinoma(224;0.008)		ACGAGAGCAGCGAAGGGTCCT	0.617000													6	10					0	0	1	0	0
ATOH8	84913	broad.mit.edu	37	2	85982020	85982020	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:85982020C>T	ENST00000306279.3	+	1	1004	c.708C>T	c.(706-708)aaC>aaT	p.N236N	ATOH8_ENST00000463422.1_3'UTR	NM_032827.6	NP_116216.2	Q96SQ7	ATOH8_HUMAN	atonal homolog 8 (Drosophila)	236					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(2)	5						TCCTGGCGAACGCCAGGGAGC	0.701000													19	68					0	0	1	0	0
TRIM21	6737	broad.mit.edu	37	11	4411450	4411450	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:4411450G>A	ENST00000254436.7	-	2	302	c.190C>T	c.(190-192)Cgg>Tgg	p.R64W	TRIM21_ENST00000543625.1_Missense_Mutation_p.R64W	NM_003141.3	NP_003132.2	P19474	RO52_HUMAN	tripartite motif containing 21	64					cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)	16		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		CGATTGGGCCGGAGATTCTTG	0.577000													46	34					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102051108	102051108	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:102051108G>C	ENST00000318222.3	-	12	2339	c.1957C>G	c.(1957-1959)Ctg>Gtg	p.L653V	PKD2L1_ENST00000338519.3_Missense_Mutation_p.L578V|PKD2L1_ENST00000353274.3_Missense_Mutation_p.L653V	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	653					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TTCTCATCCAGAATACGATTC	0.502000													3	60					0	0	1	0	0
CTSF	8722	broad.mit.edu	37	11	66332255	66332255	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:66332255C>G	ENST00000310325.5	-	10	1297	c.1188G>C	c.(1186-1188)aaG>aaC	p.K396N		NM_003793.3	NP_003784.2	Q9UBX1	CATF_HUMAN	cathepsin F	396					proteolysis	lysosome	cysteine-type endopeptidase activity			endometrium(1)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	19						TTGGGCCTCTCTTGGCCAGCC	0.652000													23	3					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178634647	178634647	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:178634647G>A	ENST00000251582.7	-	4	859	c.758C>T	c.(757-759)tCg>tTg	p.S253L	ADAMTS2_ENST00000274609.5_Missense_Mutation_p.S253L	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	253					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCTCCGCCTCGAGCTGTTGGC	0.657000													25	40					0	0	1	0	0
PNLIPRP2	5408	broad.mit.edu	37	10	118380838	118380838	+	RNA	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:118380838C>T	ENST00000537242.1	+	0	47				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		CTTGGACCCTCGGCCTTCTCC	0.592000													8	7					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43056985	43056985	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr20:43056985C>T	ENST00000316099.4	+	9	1229	c.1140C>T	c.(1138-1140)agC>agT	p.S380S	HNF4A_ENST00000316673.4_Silent_p.S358S|HNF4A_ENST00000415691.2_Silent_p.S380S|HNF4A_ENST00000457232.1_Silent_p.S358S	NM_000457.4|NM_001258355.1|NM_178849.2	NP_000448.3|NP_001245284.1|NP_849180.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha						blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGTCCCCCAGCGATGCACCCC	0.592000													15	19					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168298958	168298958	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:168298958G>C	ENST00000366806.2	+	11	1533	c.1391G>C	c.(1390-1392)aGa>aCa	p.R464T	MLLT4_ENST00000447894.2_Missense_Mutation_p.R464T|MLLT4_ENST00000392108.3_Missense_Mutation_p.R464T|MLLT4_ENST00000392112.1_Missense_Mutation_p.R448T|MLLT4_ENST00000351017.4_Missense_Mutation_p.R464T|MLLT4_ENST00000400822.3_Missense_Mutation_p.R463T|MLLT4_ENST00000344191.4_Missense_Mutation_p.R464T			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	464	FHA.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GTGACGCCCAGAAGTATGGAC	0.517000			T	MLL	AL								20	19					0	0	1	0	0
EEF2K	29904	broad.mit.edu	37	16	22285043	22285043	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:22285043G>A	ENST00000263026.5	+	16	2335	c.1861G>A	c.(1861-1863)Gac>Aac	p.D621N		NM_013302.3	NP_037434	O00418	EF2K_HUMAN	eukaryotic elongation factor-2 kinase	621	Pseudosubstrate/autoinhibitory domain (Potential).				insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(8)|large_intestine(2)|lung(13)|ovary(1)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(48;0.0223)		GCGAGCTTTTGACTCTGGCCA	0.557000													16	34					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42531777	42531777	+	Silent	SNP	T	T	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr18:42531777T>C	ENST00000282030.5	+	4	2768	c.2472T>C	c.(2470-2472)agT>agC	p.S824S		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	824						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GAATACACAGTGGAACCTGGA	0.517000									Schinzel-Giedion syndrome				27	48					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116411636	116411636	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:116411636G>T	ENST00000397752.3	+	13	3015	c.2815G>T	c.(2815-2817)Gtc>Ttc	p.V939F	MET_ENST00000318493.6_Missense_Mutation_p.V957F	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	939					axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TGCTGGTGTTGTCTCAATATC	0.348000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				26	120					7.33532e-06	7.52181e-06	1	1	0
ZFAND5	7763	broad.mit.edu	37	9	74971943	74971943	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr9:74971943G>A	ENST00000237937.3	-	5	954	c.397C>T	c.(397-399)Cag>Tag	p.Q133*	ZFAND5_ENST00000343431.2_Nonsense_Mutation_p.Q133*|ZFAND5_ENST00000376960.4_Nonsense_Mutation_p.Q133*|ZFAND5_ENST00000488164.1_5'UTR|ZFAND5_ENST00000376962.5_Nonsense_Mutation_p.Q133*	NM_001102421.1|NM_001278243.1|NM_001278244.1|NM_001278245.1|NM_006007.2	NP_001095891.1|NP_001265172.1|NP_001265173.1|NP_001265174.1|NP_005998.1	O76080	ZFAN5_HUMAN	zinc finger, AN1-type domain 5	133							DNA binding|zinc ion binding	p.Q133*(1)		cervix(1)|kidney(2)|lung(2)|prostate(1)	6						GTACTGGGCTGAGAAACTGAT	0.383000													24	60					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39106841	39106841	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:39106841A>T	ENST00000591517.1	-	4	335	c.307T>A	c.(307-309)Tac>Aac	p.Y103N	MAP4K1_ENST00000396857.2_Missense_Mutation_p.Y103N|MAP4K1_ENST00000589130.1_Missense_Mutation_p.Y99N|MAP4K1_ENST00000586296.1_Missense_Mutation_p.Y103N	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	103	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TAACCTTGGTAGATGTCCTGG	0.502000													19	54					0	0	1	0	0
CD28	940	broad.mit.edu	37	2	204571318	204571318	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:204571318C>T	ENST00000458610.2	+	1	72	c.72C>T	c.(70-72)gaC>gaT	p.D24D	CD28_ENST00000324106.8_5'UTR|CD28_ENST00000374481.3_5'UTR			P10747	CD28_HUMAN	CD28 molecule	10					cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13						CCGTGGATGACGGAGACTCTC	0.577000													6	9					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228175592	228175592	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:228175592G>T	ENST00000396578.3	+	51	5018	c.4856G>T	c.(4855-4857)aGa>aTa	p.R1619I	AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000396588.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1619	Collagen IV NC1.|Required for the anti-tumor cell activity of tumstatin.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TGTCATGGAAGAGGAACGTGC	0.483000													18	67					4.30721e-22	4.70939e-22	1	1	0
WDHD1	11169	broad.mit.edu	37	14	55424327	55424327	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:55424327G>A	ENST00000360586.3	-	22	2793	c.2728C>T	c.(2728-2730)Cga>Tga	p.R910*	WDHD1_ENST00000359167.4_Nonsense_Mutation_p.R428*|WDHD1_ENST00000420358.2_Nonsense_Mutation_p.R787*|WDHD1_ENST00000421192.1_Nonsense_Mutation_p.R787*	NM_007086.3	NP_009017.1	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	910						cytoplasm|nucleoplasm	DNA binding			breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(2)	42						GGATTTACTCGTCCTTGGCTG	0.323000													3	51					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80646695	80646695	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:80646695T>A	ENST00000466387.1	+	13	1983	c.1259T>A	c.(1258-1260)gTt>gAt	p.V420D	CTNNA2_ENST00000496558.1_Missense_Mutation_p.V420D|CTNNA2_ENST00000402739.4_Missense_Mutation_p.V420D|CTNNA2_ENST00000361291.4_Missense_Mutation_p.V454D|CTNNA2_ENST00000540488.1_Missense_Mutation_p.V420D|CTNNA2_ENST00000343114.3_Missense_Mutation_p.V99D|CTNNA2_ENST00000541047.1_Missense_Mutation_p.V420D			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	420					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TATGCCCAAGTTTTCCGTGAG	0.443000													29	52					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31599563	31599563	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr18:31599563C>T	ENST00000261592.5	-	6	1072	c.775G>A	c.(775-777)Gat>Aat	p.D259N	NOL4_ENST00000538587.1_Missense_Mutation_p.D185N|NOL4_ENST00000535384.1_5'UTR|NOL4_ENST00000269185.4_Missense_Mutation_p.D145N|NOL4_ENST00000589544.1_Missense_Mutation_p.D259N|NOL4_ENST00000535475.1_Missense_Mutation_p.D104N	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	259						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						GCAGCAGAATCATCTGTTGGA	0.403000													17	56					0	0	1	0	0
ZNF473	25888	broad.mit.edu	37	19	50542429	50542429	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:50542429C>T	ENST00000595661.1	+	4	516	c.21C>T	c.(19-21)acC>acT	p.T7T	ZNF473_ENST00000601364.1_Silent_p.T7T|ZNF473_ENST00000391821.2_Silent_p.T7T|ZNF473_ENST00000445728.3_5'UTR|ZNF473_ENST00000270617.3_Silent_p.T7T			Q8WTR7	ZN473_HUMAN	zinc finger protein 473	7	KRAB.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		AATTTGTGACCCTCAAGGATG	0.577000													23	76					0	0	1	0	0
DPY19L2P2	349152	broad.mit.edu	37	7	102895314	102895314	+	RNA	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:102895314C>G	ENST00000312132.4	-	0	2530																											CAAGCAGGATCTCGCAATCCT	0.338000													11	21					0	0	1	0	0
TINAG	27283	broad.mit.edu	37	6	54191662	54191662	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:54191662G>A	ENST00000259782.4	+	4	668	c.572G>A	c.(571-573)cGc>cAc	p.R191H	TINAG_ENST00000370869.3_Missense_Mutation_p.R187H|TINAG_ENST00000370864.3_Missense_Mutation_p.R173H	NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	191					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity	p.R191H(1)|p.R191L(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TTTAAATTTCGCCTTGGCACT	0.373000													14	113					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152690229	152690229	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:152690229G>A	ENST00000367255.5	-	61	10286	c.9685C>T	c.(9685-9687)Cag>Tag	p.Q3229*	SYNE1_ENST00000341594.5_Nonsense_Mutation_p.Q3268*|SYNE1_ENST00000448038.1_Nonsense_Mutation_p.Q3236*|SYNE1_ENST00000423061.1_Nonsense_Mutation_p.Q3236*|SYNE1_ENST00000265368.4_Nonsense_Mutation_p.Q3229*	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3229					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGTTGAGCTGAGGCTCGTAG	0.512000										HNSCC(10;0.0054)			18	15					0	0	1	0	0
GIPC3	126326	broad.mit.edu	37	19	3586821	3586821	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:3586821G>A	ENST00000322315.5	+	3	466	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K		NM_133261.2	NP_573568.1	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	141	PDZ.									breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGAATCAAGGAAGGCAGTAT	0.627000											OREG0025154	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	8					0	0	1	0	0
DPEP2	64174	broad.mit.edu	37	16	68024029	68024029	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:68024029C>T	ENST00000412757.2	-	9	1580	c.915G>A	c.(913-915)aaG>aaA	p.K305K	DPEP2_ENST00000393847.1_Silent_p.K305K|DPEP2_ENST00000572888.1_Silent_p.K305K			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	305					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		CGCCACCGTTCTTCTTCTGCA	0.587000													16	26					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117043445	117043445	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chrX:117043445G>A	ENST00000371876.1	-	4	3453	c.1032C>T	c.(1030-1032)ggC>ggT	p.G344G	KLHL13_ENST00000541812.1_Silent_p.G379G|KLHL13_ENST00000371882.1_Silent_p.G344G|KLHL13_ENST00000539496.1_Silent_p.G398G|KLHL13_ENST00000540167.1_Silent_p.G379G|KLHL13_ENST00000469946.1_Silent_p.G344G|KLHL13_ENST00000545703.1_Silent_p.G353G|KLHL13_ENST00000371878.1_Silent_p.G344G|KLHL13_ENST00000262820.3_Silent_p.G395G			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	395					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						TACTCTGTCCGCCAACCACAT	0.428000													3	35					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179474518	179474518	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:179474518C>A	ENST00000589042.1	-	272	51856	c.51632G>T	c.(51631-51633)gGa>gTa	p.G17211V	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G14643V|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G8271V|TTN_ENST00000460472.2_Missense_Mutation_p.G8146V|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G8338V|TTN_ENST00000591111.1_Missense_Mutation_p.G15570V|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15570	Fibronectin type-III 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTTCAAGTCCTTTTGCTGT	0.473000													27	288					5.09552e-08	5.28478e-08	1	1	0
FDXACB1	91893	broad.mit.edu	37	11	111746266	111746266	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:111746266G>A	ENST00000260257.4	-	5	1302	c.1255C>T	c.(1255-1257)Cta>Tta	p.L419L	ALG9_ENST00000527377.1_Intron|FDXACB1_ENST00000542429.1_Silent_p.L270L|ALG9_ENST00000524880.1_Intron	NM_138378.2	NP_612387.1	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain containing 1	419					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(3)	19						AGGCTATCTAGAATGCCCTTC	0.418000													55	59					0	0	1	0	0
MTF2	22823	broad.mit.edu	37	1	93584938	93584938	+	Silent	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:93584938C>G	ENST00000370298.4	+	8	1066	c.777C>G	c.(775-777)ctC>ctG	p.L259L	MTF2_ENST00000545708.1_Silent_p.L157L|MTF2_ENST00000471953.1_3'UTR|MTF2_ENST00000370303.4_Silent_p.L259L|MTF2_ENST00000540243.1_Silent_p.L157L	NM_001164392.1|NM_007358.3	NP_001157864.1|NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription factor 2	259						nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		CAGAATACCTCAAACGTCTAC	0.308000													11	47					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17794613	17794613	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:17794613C>G	ENST00000378814.5	-	25	3088	c.3089G>C	c.(3088-3090)aGa>aCa	p.R1030T	KIF13A_ENST00000378816.5_Missense_Mutation_p.R1030T|KIF13A_ENST00000378826.2_Missense_Mutation_p.R1030T|KIF13A_ENST00000378843.2_Missense_Mutation_p.R1030T|KIF13A_ENST00000259711.6_Missense_Mutation_p.R1030T	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	1030					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			GACTTGTACTCTACGGGAATG	0.493000													4	230					0	0	1	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90574020	90574020	+	RNA	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:90574020G>A	ENST00000551025.1	+	0	4029							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		ATAGTCCAGTGAGACCTGTAG	0.368000													7	9					0	0	1	0	0
PAFAH2	5051	broad.mit.edu	37	1	26310994	26310994	+	Missense_Mutation	SNP	C	C	T	rs142549027		TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:26310994C>T	ENST00000374282.3	-	5	546	c.367G>A	c.(367-369)Gag>Aag	p.E123K	PAFAH2_ENST00000374284.1_Missense_Mutation_p.E123K|PAFAH2_ENST00000493892.1_5'UTR	NM_000437.3	NP_000428.2	Q99487	PAFA2_HUMAN	platelet-activating factor acetylhydrolase 2, 40kDa	123					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			NS(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|urinary_tract(1)	9		Colorectal(325;3.47e-05)|Lung NSC(340;6.23e-05)|all_lung(284;9.48e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-25)|Colorectal(126;3.57e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00717)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGCCAGCTCCATGCAGAAG	0.517000													4	19					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37665828	37665828	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr21:37665828G>T	ENST00000399151.3	+	37	6941	c.6856G>T	c.(6856-6858)Gaa>Taa	p.E2286*		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	2286					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						ACAACTGGAAGAATGCATCGA	0.403000													13	118					0.00136819	0.0013951	1	1	0
SLC24A1	9187	broad.mit.edu	37	15	65944008	65944008	+	Splice_Site	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:65944008G>T	ENST00000261892.6	+	8	3081	c.2794G>T	c.(2794-2796)Gag>Tag	p.E932*	SLC24A1_ENST00000544319.2_Splice_Site_p.E818*|SLC24A1_ENST00000537259.1_Splice_Site_p.E914*|SLC24A1_ENST00000399033.4_Intron|SLC24A1_ENST00000449142.2_3'UTR|SLC24A1_ENST00000339868.6_Splice_Site_p.E914*|SLC24A1_ENST00000546330.1_Splice_Site_p.E914*	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	932					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						TTTCAAACAGGAGTCTAGGAA	0.443000													6	16					5.9392e-07	6.1248e-07	1	1	0
DTX3	196403	broad.mit.edu	37	12	58002887	58002887	+	Silent	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:58002887G>T	ENST00000548198.1	+	5	2500	c.996G>T	c.(994-996)ctG>ctT	p.L332L	DTX3_ENST00000551632.1_Silent_p.L335L|DTX3_ENST00000548804.1_Silent_p.L332L|DTX3_ENST00000337737.3_Silent_p.L332L			Q8N9I9	DTX3_HUMAN	deltex homolog 3 (Drosophila)	332					Notch signaling pathway	cytoplasm	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)|urinary_tract(1)	12	Melanoma(17;0.122)					CCACCTACCTGACCCGGGTGC	0.552000													30	25					1.26612e-14	1.35575e-14	1	1	0
LRRC6	23639	broad.mit.edu	37	8	133595958	133595958	+	Silent	SNP	T	T	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:133595958T>C	ENST00000519595.1	-	11	1307	c.1209A>G	c.(1207-1209)agA>agG	p.R403R	LRRC6_ENST00000518642.1_Silent_p.R400R|LRRC6_ENST00000250173.1_Silent_p.R403R			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	403						cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTGTTTGTTCTCTGCTCCTGT	0.403000													41	104					0	0	1	0	0
TXNL4A	10907	broad.mit.edu	37	18	77733766	77733766	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr18:77733766G>A	ENST00000269601.5	-	3	548	c.348C>T	c.(346-348)atC>atT	p.I116I	TXNL4A_ENST00000585474.1_Silent_p.I45I|TXNL4A_ENST00000592957.1_Silent_p.I45I|TXNL4A_ENST00000592837.1_Silent_p.I45I|TXNL4A_ENST00000588162.1_3'UTR	NM_006701.2	NP_006692.1	P83876	TXN4A_HUMAN	thioredoxin-like 4A	116					cell division|mitosis|spliceosome assembly	nucleoplasm|spliceosomal complex	protein binding			breast(1)|large_intestine(1)|lung(3)	5		all_cancers(4;1.15e-12)|all_epithelial(4;8.61e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0646)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;7.36e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0249)		ACACCGTCTCGATGATGTCCA	0.592000													46	87					0	0	1	0	0
CATSPER3	347732	broad.mit.edu	37	5	134331986	134331986	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:134331986C>T	ENST00000282611.6	+	3	362	c.276C>T	c.(274-276)tcC>tcT	p.S92S		NM_178019.2	NP_821138.1	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	92					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity	p.S92S(1)		NS(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCTTTGTGTCCATCTGCACAT	0.512000													21	31					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31283199	31283199	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:31283199G>A	ENST00000544665.3	+	7	661	c.590G>A	c.(589-591)cGg>cAg	p.R197Q	ITGAM_ENST00000287497.8_Missense_Mutation_p.R197Q	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	197	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						GAAGAATTCCGGATTCACTTT	0.557000													8	35					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151097931	151097931	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:151097931C>T	ENST00000474524.1	+	30	4442	c.4404C>T	c.(4402-4404)ctC>ctT	p.L1468L	P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000273432.4_Silent_p.L1328L	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1468					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AACCCTTCCTCTCACTGGTAC	0.373000													16	50					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89350177	89350177	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:89350177C>A	ENST00000301030.4	-	9	3233	c.2773G>T	c.(2773-2775)Gaa>Taa	p.E925*	ANKRD11_ENST00000378330.2_Nonsense_Mutation_p.E925*	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	925	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTATGCTTTTCGGTCTGCTCT	0.547000													41	39					1.15183e-24	1.27087e-24	1	1	0
TTC31	64427	broad.mit.edu	37	2	74710478	74710478	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:74710478G>C	ENST00000410003.1	+	2	79	c.70G>C	c.(70-72)Gag>Cag	p.E24Q	TTC31_ENST00000442235.2_5'UTR|TTC31_ENST00000463189.1_3'UTR|TTC31_ENST00000233623.5_Missense_Mutation_p.E24Q			Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	24							binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9						CTGCCCACTGGAGGTCGCTGC	0.587000											OREG0014719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	68	68					0	0	1	0	0
BPIFA3	128861	broad.mit.edu	37	20	31811656	31811656	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr20:31811656G>A	ENST00000375454.3	+	2	377	c.167G>A	c.(166-168)cGa>cAa	p.R56Q	BPIFA3_ENST00000375452.3_Missense_Mutation_p.R56Q|BPIFA3_ENST00000490499.1_3'UTR	NM_178466.3	NP_848561.2	Q9BQP9	SPLC3_HUMAN	BPI fold containing family A, member 3	56						extracellular region	lipid binding										GCAGAAAGCCGAATTCAGAAC	0.552000													9	44					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38937378	38937378	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:38937378C>T	ENST00000355481.4	+	9	901	c.770C>T	c.(769-771)tCc>tTc	p.S257F	RYR1_ENST00000360985.3_Missense_Mutation_p.S257F|RYR1_ENST00000359596.3_Missense_Mutation_p.S257F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	257	MIR 3.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CATGCCCGCTCCCTCTGGAGG	0.602000													24	52					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54114420	54114420	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:54114420G>C	ENST00000404125.1	-	40	4760	c.4705C>G	c.(4705-4707)Cag>Gag	p.Q1569E	PSME4_ENST00000421748.2_Missense_Mutation_p.Q713E|PSME4_ENST00000476586.1_5'UTR	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	1569					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TTAATGCCCTGAGTTCGCTCA	0.358000													30	65					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73535372	73535372	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:73535372G>A	ENST00000418310.1	+	15	1966	c.1864G>A	c.(1864-1866)Gag>Aag	p.E622K	LIMK1_ENST00000336180.2_Missense_Mutation_p.E592K|LIMK1_ENST00000538333.3_Missense_Mutation_p.E558K			P53667	LIMK1_HUMAN	LIM domain kinase 1	592					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				TCTGGACCCCGAGAAGAGGTG	0.672000													68	53					0	0	1	0	0
FDXACB1	91893	broad.mit.edu	37	11	111746692	111746692	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:111746692G>A	ENST00000260257.4	-	5	876	c.829C>T	c.(829-831)Ctt>Ttt	p.L277F	ALG9_ENST00000527377.1_5'UTR|FDXACB1_ENST00000542429.1_Missense_Mutation_p.L128F|ALG9_ENST00000524880.1_Intron	NM_138378.2	NP_612387.1	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain containing 1	277					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(3)	19						CAGAAAGGAAGAACACTGGTA	0.428000													19	29					0	0	1	0	0
FKBP9	11328	broad.mit.edu	37	7	32997311	32997311	+	Translation_Start_Site	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:32997311C>A	ENST00000538443.1	+	0	226				FKBP9_ENST00000538336.1_Missense_Mutation_p.F42L|FKBP9_ENST00000242209.4_Missense_Mutation_p.F42L|AVL9_ENST00000404479.1_Intron			O95302	FKBP9_HUMAN	FK506 binding protein 9, 63 kDa						protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			AGCGGCGCTTCGTGCCCGACG	0.726000													3	0					0.004672	0.00473725	1	1	0
MYH10	4628	broad.mit.edu	37	17	8439216	8439216	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:8439216C>T	ENST00000360416.3	-	15	1777	c.1639G>A	c.(1639-1641)Gaa>Aaa	p.E547K	MYH10_ENST00000396239.1_Missense_Mutation_p.E537K|MYH10_ENST00000379980.4_Missense_Mutation_p.E553K|MYH10_ENST00000269243.4_Missense_Mutation_p.E537K	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	537	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CAGCATTCTTCATCCAAAAGG	0.428000													52	56					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144946044	144946044	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:144946044C>G	ENST00000525985.1	-	2	1449	c.1378G>C	c.(1378-1380)Gag>Cag	p.E460Q				P58107	EPIPL_HUMAN	epiplakin 1	460						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGCCCGGTCTCTGGGTCGGTG	0.672000													31	23					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27087558	27087558	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:27087558C>G	ENST00000324856.7	+	5	2503	c.2132C>G	c.(2131-2133)tCa>tGa	p.S711*	ARID1A_ENST00000457599.2_Nonsense_Mutation_p.S711*|ARID1A_ENST00000374152.2_Nonsense_Mutation_p.S328*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	711					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CAGTCTCGCTCAGGACCACTC	0.602000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								25	14					0	0	1	0	0
C5AR1	728	broad.mit.edu	37	19	47823943	47823943	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:47823943C>T	ENST00000355085.3	+	2	931	c.909C>T	c.(907-909)gcC>gcT	p.A303A		NM_001736.3	NP_001727.1	P21730	C5AR_HUMAN	complement component 5a receptor 1	303					activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)	20		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		ACGTGGTGGCCGGCCAGGGCT	0.587000													16	54					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70319378	70319378	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:70319378C>G	ENST00000338508.4	-	33	5148	c.5149G>C	c.(5149-5151)Gag>Cag	p.E1717Q	SHANK2_ENST00000449833.2_Missense_Mutation_p.E1121Q|SHANK2_ENST00000409161.1_Missense_Mutation_p.E1120Q|SHANK2_ENST00000423696.2_Missense_Mutation_p.E1337Q			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1337					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTGTTCATCTCTGTTGGCGAG	0.632000													25	7					0	0	1	0	0
FURIN	5045	broad.mit.edu	37	15	91424800	91424800	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:91424800C>T	ENST00000268171.3	+	16	2356	c.2077C>T	c.(2077-2079)Cgg>Tgg	p.R693W		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	693	Cys-rich.				cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GCAGCCACCTCGGCTGCCCCC	0.711000													18	7					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768064	57768064	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr20:57768064G>T	ENST00000371030.2	+	1	1990	c.1990G>T	c.(1990-1992)Gca>Tca	p.A664S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	664						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCAGAAAGAGGCAGCAGGGAG	0.592000													19	10					4.63292e-17	5.00521e-17	1	1	0
PPP1CC	5501	broad.mit.edu	37	12	111168532	111168532	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:111168532G>A	ENST00000335007.5	-	3	410	c.220C>T	c.(220-222)Cga>Tga	p.R74*	PPP1CC_ENST00000551676.1_Nonsense_Mutation_p.R74*|PPP1CC_ENST00000340766.5_Nonsense_Mutation_p.R74*|PPP1CC_ENST00000546933.1_Nonsense_Mutation_p.R83*|PPP1CC_ENST00000550991.1_Nonsense_Mutation_p.R74*	NM_002710.3	NP_002701.1	P36873	PP1G_HUMAN	protein phosphatase 1, catalytic subunit, gamma isozyme	74					cell division|glycogen metabolic process|mitotic prometaphase|triglyceride catabolic process	cleavage furrow|condensed chromosome kinetochore|cytosol|midbody|MLL5-L complex|nuclear speck|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein kinase binding|protein serine/threonine phosphatase activity			central_nervous_system(1)|large_intestine(2)|lung(3)	6						TCAAAAAGTCGCAGCAAATCA	0.443000													19	21					0	0	1	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973439	46973439	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:46973439G>A	ENST00000313683.10	-	2	1159	c.854C>T	c.(853-855)tCa>tTa	p.S285L	PNMAL1_ENST00000602246.1_Intron|PNMAL1_ENST00000438932.2_Missense_Mutation_p.S285L	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	285										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		GATCGGCTCTGAGATCGCCAT	0.532000													40	91					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32741583	32741583	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:32741583C>T	ENST00000333070.4	+	7	650	c.550C>T	c.(550-552)Cgt>Tgt	p.R184C	LCK_ENST00000336890.5_Missense_Mutation_p.R184C|LCK_ENST00000373564.3_Missense_Mutation_p.R242C	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	184	Interaction with PTPRH.|SH2.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	TTACAAGATCCGTAATCTGGA	0.537000			T	TRB@	T-ALL								10	37					0	0	1	0	0
IQSEC2	23096	broad.mit.edu	37	X	53270974	53270974	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chrX:53270974G>C	ENST00000396435.3	-	10	3207	c.3007C>G	c.(3007-3009)Ctc>Gtc	p.L1003V	IQSEC2_ENST00000375368.5_Missense_Mutation_p.L993V|IQSEC2_ENST00000375365.2_Missense_Mutation_p.L798V	NM_001111125.2	NP_001104595.1	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2	993	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(4)|skin(1)	29						ACCACAAGGAGATCATTGAAG	0.557000													11	3					0	0	1	0	0
IRF2	3660	broad.mit.edu	37	4	185320141	185320141	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr4:185320141C>G	ENST00000393593.3	-	7	829	c.622G>C	c.(622-624)Gag>Cag	p.E208Q		NM_002199.3	NP_002190.2	P14316	IRF2_HUMAN	interferon regulatory factor 2	208					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	22		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		TCGTCGCTCTCAGTGGTCACC	0.552000													4	36					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52725404	52725404	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:52725404C>T	ENST00000322088.6	+	13	1629	c.1571C>T	c.(1570-1572)aCg>aTg	p.T524M	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.T469M|PPP2R1A_ENST00000462990.1_Missense_Mutation_p.T345M	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	524	PP2A subunit C binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		ATGCTACCCACGGTTCTGCGC	0.592000			Mis		clear cell ovarian carcinoma								4	12					0	0	1	0	0
KIF23	9493	broad.mit.edu	37	15	69714344	69714344	+	Silent	SNP	A	A	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:69714344A>C	ENST00000260363.4	+	5	447	c.330A>C	c.(328-330)acA>acC	p.T110T	KIF23_ENST00000352331.4_Silent_p.T110T|KIF23_ENST00000395392.2_Silent_p.T110T|KIF23_ENST00000559279.1_Silent_p.T110T	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	110	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						TTCTTTTTACATATGGTGTGA	0.398000													20	36					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144916593	144916593	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:144916593G>A	ENST00000529945.1	-	9	2690	c.2251C>T	c.(2251-2253)Cat>Tat	p.H751Y	PDE4DIP_ENST00000313431.9_Missense_Mutation_p.H751Y|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.H588Y|PDE4DIP_ENST00000369359.4_Missense_Mutation_p.H725Y|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.H725Y|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.H588Y|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.H588Y|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.H588Y|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.H654Y|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.H375Y			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	588					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTCCTATCATGAAGAGACGTC	0.413000			T	PDGFRB	MPD								106	734					0	0	1	0	0
C17orf67	339210	broad.mit.edu	37	17	54893150	54893150	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:54893150C>A	ENST00000397861.2	-	5	1301	c.22G>T	c.(22-24)Gtg>Ttg	p.V8L	C17orf67_ENST00000575658.1_Missense_Mutation_p.V32L|C17orf67_ENST00000397862.2_Missense_Mutation_p.V32L			Q0P5P2	CQ067_HUMAN	chromosome 17 open reading frame 67	32						extracellular region				NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	7	Breast(9;2.49e-06)					AGAGACAGCACGAGCACAGGC	0.468000													11	33					6.40141e-05	6.54567e-05	1	1	0
PHKA2	5256	broad.mit.edu	37	X	18936904	18936904	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chrX:18936904G>A	ENST00000379942.4	-	19	2697	c.2032C>T	c.(2032-2034)Cct>Tct	p.P678S		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	678					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					CAAAGAGGAGGCAGATAGGAC	0.453000													31	6					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109268550	109268550	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:109268550C>A	ENST00000370017.3	+	6	1312	c.1035C>A	c.(1033-1035)ttC>ttA	p.F345L	FNDC7_ENST00000271311.2_Missense_Mutation_p.F346L	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	346	Fibronectin type-III 4.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		AGTGTGGCTTCACTTATTTTA	0.398000													42	89					9.14704e-12	9.6804e-12	1	1	0
NF1	4763	broad.mit.edu	37	17	29490319	29490319	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:29490319G>T	ENST00000358273.4	+	4	787	c.404G>T	c.(403-405)cGg>cTg	p.R135L	NF1_ENST00000356175.3_Missense_Mutation_p.R135L|NF1_ENST00000431387.4_Missense_Mutation_p.R135L	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	135					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GCTGAACTTCGGAATTCTGCC	0.443000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			39	29					1.49673e-21	1.63157e-21	1	1	0
OR1F2P	26184	broad.mit.edu	37	16	3265875	3265875	+	RNA	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:3265875C>G	ENST00000576468.1	+	0	418																											ACTCAGGACTCAAACCATCTC	0.502000													25	16					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20139724	20139724	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:20139724C>T	ENST00000396085.1	+	39	7580	c.7219C>T	c.(7219-7221)Ccc>Tcc	p.P2407S	NAV2_ENST00000311043.8_Missense_Mutation_p.P1468S|NAV2_ENST00000396087.3_Missense_Mutation_p.P2463S|NAV2_ENST00000527559.2_Missense_Mutation_p.P2392S|NAV2_ENST00000360655.4_Missense_Mutation_p.P2340S|NAV2_ENST00000533917.1_Missense_Mutation_p.P1468S|NAV2_ENST00000349880.4_Missense_Mutation_p.P2404S|NAV2_ENST00000540292.1_Missense_Mutation_p.P2394S	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	2463						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						CTACTCCAGCCCCCAGAGCTA	0.582000													24	27					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096930	167096930	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:167096930C>A	ENST00000361200.2	+	6	2728	c.2562C>A	c.(2560-2562)taC>taA	p.Y854*	DUSP27_ENST00000271385.5_Nonsense_Mutation_p.Y854*|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Nonsense_Mutation_p.Y854*			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	854					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						TGTCTGAGTACAAAATGGAAA	0.498000													14	28					1.5842e-08	1.65248e-08	1	1	0
PRADC1	84279	broad.mit.edu	37	2	73455601	73455601	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:73455601G>A	ENST00000258083.2	-	5	615	c.548C>T	c.(547-549)cCg>cTg	p.P183L	PRADC1_ENST00000480093.1_5'UTR	NM_032319.1	NP_115695.1	Q9BSG0	PADC1_HUMAN	protease-associated domain containing 1	183						extracellular region				endometrium(1)|large_intestine(1)|lung(2)	4						GGTCCAGGGCGGTTGCAGCAG	0.532000													14	21					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147889528	147889528	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:147889528G>A	ENST00000360693.3	-	6	705	c.567C>T	c.(565-567)aaC>aaT	p.N189N	HTR4_ENST00000521530.1_Silent_p.N189N|HTR4_ENST00000521735.1_Silent_p.N189N|HTR4_ENST00000520514.1_Silent_p.N189N|HTR4_ENST00000377888.3_Silent_p.N189N|HTR4_ENST00000517929.1_Silent_p.N189N|HTR4_ENST00000354217.2_Silent_p.N189N|HTR4_ENST00000362016.2_Silent_p.N203N|HTR4_ENST00000314512.6_Silent_p.N189N	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	189					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	CGTAGGGCTTGTTGACCATGA	0.483000													4	6					0	0	1	0	0
USP10	9100	broad.mit.edu	37	16	84778274	84778274	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:84778274G>A	ENST00000219473.7	+	4	300	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	USP10_ENST00000570191.1_Missense_Mutation_p.E67K|USP10_ENST00000562743.1_3'UTR	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	63	Interaction with p53/TP53.				DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						TGGTGTCGATGAAGTCATTGA	0.413000													7	10					0	0	1	0	0
WDR3	10885	broad.mit.edu	37	1	118492707	118492707	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:118492707C>G	ENST00000349139.5	+	15	1747	c.1700C>G	c.(1699-1701)tCt>tGt	p.S567C		NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3							nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TTGGCTGTGTCTTTGCTGGAC	0.413000													57	141					0	0	1	0	0
NFIX	4784	broad.mit.edu	37	19	13189483	13189483	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:13189483C>T	ENST00000397661.2	+	7	1242	c.1012C>T	c.(1012-1014)Cag>Tag	p.Q338*	NFIX_ENST00000358552.3_Intron|NFIX_ENST00000588228.1_Nonsense_Mutation_p.Q291*|NFIX_ENST00000587260.1_Nonsense_Mutation_p.Q337*|NFIX_ENST00000592199.1_Nonsense_Mutation_p.Q338*|NFIX_ENST00000585575.1_Nonsense_Mutation_p.Q330*|NFIX_ENST00000587760.1_Nonsense_Mutation_p.Q330*|NFIX_ENST00000360105.4_Intron	NM_002501.2	NP_002492.2	Q14938	NFIX_HUMAN	nuclear factor I/X (CCAAT-binding transcription factor)	338					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			CCTCTCCTCTCAGGGCAGCTC	0.637000													5	9					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762434	130762434	+	Silent	SNP	A	A	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:130762434A>G	ENST00000392429.1	+	2	3245	c.867A>G	c.(865-867)acA>acG	p.T289T	TMEM200A_ENST00000545622.1_Silent_p.T289T|TMEM200A_ENST00000296978.3_Silent_p.T289T	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	289						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GTGCTTTTACATTGCCTGTGA	0.408000													17	49					0	0	1	0	0
ABI2	10152	broad.mit.edu	37	2	204276052	204276052	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:204276052C>A	ENST00000261017.5	+	8	1271	c.1036C>A	c.(1036-1038)Cag>Aag	p.Q346K	ABI2_ENST00000295851.5_Intron|ABI2_ENST00000430574.1_Intron|ABI2_ENST00000261018.7_Intron|ABI2_ENST00000422511.2_Intron|ABI2_ENST00000430418.1_Intron|ABI2_ENST00000261016.6_Intron|RAPH1_ENST00000457812.1_Intron|ABI2_ENST00000424558.1_Intron	NM_005759.4	NP_005750.4	Q9NYB9	ABI2_HUMAN	abl-interactor 2	399	Pro-rich.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding			breast(1)|kidney(3)|large_intestine(1)|liver(2)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	15						GGTAACTCCTCAGTTACCTTT	0.393000													52	49					2.69953e-25	2.98759e-25	1	1	0
CANX	821	broad.mit.edu	37	5	179135270	179135270	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:179135270C>G	ENST00000247461.4	+	5	535	c.335C>G	c.(334-336)tCa>tGa	p.S112*	CANX_ENST00000512607.2_Nonsense_Mutation_p.S4*|CANX_ENST00000452673.2_Nonsense_Mutation_p.S112*|CANX_ENST00000503126.1_3'UTR|CANX_ENST00000415618.2_Nonsense_Mutation_p.S147*|CANX_ENST00000504734.1_Nonsense_Mutation_p.S112*	NM_001746.3	NP_001737.1	P27824	CALX_HUMAN	calnexin	112					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|prostate(2)|urinary_tract(3)	22	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATGAAGGAGTCAAAGCTTCCA	0.438000													25	52					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233897534	233897534	+	Silent	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:233897534G>C	ENST00000233840.3	+	1	153	c.153G>C	c.(151-153)ctG>ctC	p.L51L		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	51							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		ACGCAGAGCTGATTGTCCTGC	0.627000													12	15					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39262634	39262634	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr13:39262634C>T	ENST00000280481.7	+	1	1369	c.1153C>T	c.(1153-1155)Cag>Tag	p.Q385*		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	385					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CTCCTTCACTCAGAGGGATCT	0.547000													31	9					0	0	1	0	0
KIAA1524	57650	broad.mit.edu	37	3	108300287	108300287	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:108300287G>A	ENST00000295746.8	-	5	600	c.524C>T	c.(523-525)tCt>tTt	p.S175F	KIAA1524_ENST00000487834.1_5'UTR|KIAA1524_ENST00000491772.1_Missense_Mutation_p.S16F	NM_020890.2	NP_065941.2	Q8TCG1	CIP2A_HUMAN	KIAA1524	175						cytoplasm|integral to membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(21)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CGTTTGAACAGAAAGATTGTG	0.299000													20	25					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32188758	32188758	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr22:32188758C>G	ENST00000400246.1	+	12	864	c.722C>G	c.(721-723)tCa>tGa	p.S241*	DEPDC5_ENST00000535622.1_Nonsense_Mutation_p.S241*|DEPDC5_ENST00000400242.3_Nonsense_Mutation_p.S241*|DEPDC5_ENST00000382105.2_Nonsense_Mutation_p.S241*|DEPDC5_ENST00000536766.1_Nonsense_Mutation_p.S213*|DEPDC5_ENST00000400249.2_Nonsense_Mutation_p.S241*|DEPDC5_ENST00000382112.3_Nonsense_Mutation_p.S241*|DEPDC5_ENST00000382111.2_Nonsense_Mutation_p.S241*|DEPDC5_ENST00000400248.2_Nonsense_Mutation_p.S241*|DEPDC5_ENST00000266091.3_Nonsense_Mutation_p.S241*			O75140	DEPD5_HUMAN	DEP domain containing 5	241					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						AACCGAGCCTCAATTCGACAG	0.363000													83	14					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73717866	73717866	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:73717866G>A	ENST00000264448.6	+	10	8888	c.8777G>A	c.(8776-8778)cGa>cAa	p.R2926Q	ALMS1_ENST00000409009.1_Missense_Mutation_p.R2884Q	NM_015120.4	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2926					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CTTGAACAACGAGAACTCTTT	0.443000													41	196					0	0	1	0	0
CES5A	221223	broad.mit.edu	37	16	55883609	55883609	+	Silent	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:55883609G>C	ENST00000521992.1	-	12	1582	c.1437C>G	c.(1435-1437)gtC>gtG	p.V479V	CES5A_ENST00000290567.9_Silent_p.V450V|CES5A_ENST00000520435.1_Silent_p.V420V|CES5A_ENST00000518005.1_Silent_p.V344V|CES5A_ENST00000541580.1_5'UTR|CES5A_ENST00000319165.9_Intron	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	450						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GGTCGGCTTTGACAAAAGCTG	0.527000													44	48					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57648317	57648317	+	Silent	SNP	G	G	A	rs144667198	byFrequency	TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:57648317G>A	ENST00000269834.1	-	4	550	c.165C>T	c.(163-165)ccC>ccT	p.P55P		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	55	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGATCACATCGGGTTTGGTGG	0.507000													19	38					0	0	1	0	0
TRAV8-7	28679	broad.mit.edu	37	14	22600902	22600902	+	RNA	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:22600902G>A	ENST00000390456.3	+	0	247																											TTTTGAGGCTGAATTTAAGAA	0.488000													13	27					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110376836	110376836	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:110376836G>A	ENST00000378402.5	+	2	238	c.134G>A	c.(133-135)gGa>gAa	p.G45E		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	45	IPT/TIG 1.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGTATAAATGGAGCAACAAGG	0.328000										HNSCC(38;0.096)			4	24					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171510168	171510168	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:171510168G>C	ENST00000367742.3	+	16	3805	c.3563G>C	c.(3562-3564)aGa>aCa	p.R1188T	PRRC2C_ENST00000338920.4_Missense_Mutation_p.R1186T|PRRC2C_ENST00000392078.3_Missense_Mutation_p.R1188T|PRRC2C_ENST00000426496.2_Missense_Mutation_p.R1186T			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	1186							protein C-terminus binding										CAAGGATACAGAGGTCGAGGC	0.483000													10	28					0	0	1	0	0
MTDH	92140	broad.mit.edu	37	8	98718938	98718938	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:98718938C>A	ENST00000336273.3	+	8	1560	c.1232C>A	c.(1231-1233)tCa>tAa	p.S411*	MTDH_ENST00000519934.1_Nonsense_Mutation_p.S355*	NM_178812.3	NP_848927.2	Q86UE4	LYRIC_HUMAN	metadherin	411	Lung-homing for mammary tumors (By similarity).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			GAAAGAGCTTCACTTCTAAAG	0.433000													33	230					2.6416e-12	2.81203e-12	1	1	0
CHPF2	54480	broad.mit.edu	37	7	150933584	150933584	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:150933584C>T	ENST00000035307.2	+	3	2432	c.919C>T	c.(919-921)Cct>Tct	p.P307S	CHPF2_ENST00000495645.1_Missense_Mutation_p.P299S	NM_019015.1	NP_061888.1	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	307						Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(4)|prostate(1)|skin(3)	17						CGCCGTGCACCCTGTCTCCGA	0.562000													12	20					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233660833	233660833	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:233660833C>G	ENST00000373566.3	+	15	1804	c.1607C>G	c.(1606-1608)tCa>tGa	p.S536*	GIGYF2_ENST00000452341.2_Nonsense_Mutation_p.S345*|GIGYF2_ENST00000409547.1_Nonsense_Mutation_p.S514*|GIGYF2_ENST00000409451.3_Nonsense_Mutation_p.S535*|GIGYF2_ENST00000409196.3_Nonsense_Mutation_p.S508*|GIGYF2_ENST00000409480.1_Nonsense_Mutation_p.S536*|GIGYF2_ENST00000373563.4_Nonsense_Mutation_p.S514*			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	514	GYF.				cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		AGATTGGCATCAAAACTGCAA	0.403000													45	50					0	0	1	0	0
C9orf163	158055	broad.mit.edu	37	9	139379184	139379184	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr9:139379184G>T	ENST00000354376.1	+	1	1238	c.284G>T	c.(283-285)gGg>gTg	p.G95V		NM_152571.2	NP_689784.1	Q8N9P6	CI163_HUMAN	chromosome 9 open reading frame 163	95							protein binding			kidney(1)|lung(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.36e-06)|Epithelial(140;5.65e-06)		GTGGCACCAGGGCCAATCTGC	0.642000													11	15					0.010729	0.0108486	1	1	0
KLHL1	57626	broad.mit.edu	37	13	70456512	70456512	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr13:70456512T>C	ENST00000377844.4	-	5	1889	c.1130A>G	c.(1129-1131)cAt>cGt	p.H377R	KLHL1_ENST00000545028.1_Missense_Mutation_p.H184R	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	377					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CATCAATGCATGGAAGATGGT	0.438000													9	16					0	0	1	0	0
CD44	960	broad.mit.edu	37	11	35211541	35211541	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:35211541C>G	ENST00000263398.6	+	5	1030	c.596C>G	c.(595-597)tCt>tGt	p.S199C	CD44_ENST00000433892.2_Missense_Mutation_p.S199C|CD44_ENST00000437706.2_Missense_Mutation_p.S199C|CD44_ENST00000415148.2_Missense_Mutation_p.S199C|CD44_ENST00000360158.4_Missense_Mutation_p.S199C|CD44_ENST00000433354.2_Missense_Mutation_p.S199C|CD44_ENST00000526669.2_Intron|CD44_ENST00000278386.6_Intron|CD44_ENST00000449691.2_Missense_Mutation_p.S199C|CD44_ENST00000352818.4_Missense_Mutation_p.S199C|CD44_ENST00000428726.2_Missense_Mutation_p.S199C|CD44_ENST00000434472.2_Missense_Mutation_p.S199C	NM_001001391.1|NM_001202555.1|NM_001202556.1	NP_001001391.1|NP_001189484.1|NP_001189485.1	P16070	CD44_HUMAN	CD44 molecule (Indian blood group)	199					cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|skin(1)	23	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	TACACCTTTTCTACTGTACAC	0.507000													15	25					0	0	1	0	0
CCAR2	57805	broad.mit.edu	37	8	22463627	22463627	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:22463627C>T	ENST00000308511.4	+	3	337	c.88C>T	c.(88-90)Cct>Tct	p.P30S	CCAR2_ENST00000389279.3_Missense_Mutation_p.P30S|CCAR2_ENST00000521301.1_Missense_Mutation_p.P30S					cell cycle and apoptosis regulator 2	30																	TCTGGGCCCTCCTCCTGGTTT	0.542000													74	133					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43022002	43022002	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:43022002G>C	ENST00000428554.2	+	12	1744	c.601G>C	c.(601-603)Gag>Cag	p.E201Q	CCDC30_ENST00000507855.1_Intron|CCDC30_ENST00000342022.4_Missense_Mutation_p.E201Q|CCDC30_ENST00000340612.4_Missense_Mutation_p.E201Q|CCDC30_ENST00000390640.4_Intron			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	201										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						GCTTAGAGAAGAGCTGAGCCA	0.463000													5	27					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121706237	121706237	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr4:121706237C>T	ENST00000264808.3	-	11	1438	c.1198G>A	c.(1198-1200)Gag>Aag	p.E400K	PRDM5_ENST00000515109.1_Missense_Mutation_p.E369K|PRDM5_ENST00000428209.2_Missense_Mutation_p.E369K	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	400					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GGTCTCTCCTCAGAGTGGGTC	0.443000													16	27					0	0	1	0	0
CPSF3	51692	broad.mit.edu	37	2	9572670	9572670	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:9572670C>T	ENST00000460593.1	+	5	1399	c.261C>T	c.(259-261)acC>acT	p.T87T	CPSF3_ENST00000238112.3_Silent_p.T124T			Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3, 73kDa	124					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		TGCTGTATACCGAGACAGATT	0.358000													7	45					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22990158	22990158	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:22990158C>T	ENST00000313077.7	+	24	2903	c.2778C>T	c.(2776-2778)atC>atT	p.I926I	CYFIP1_ENST00000560848.1_Silent_p.I926I|CYFIP1_ENST00000435939.2_Silent_p.I495I	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	926					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		ACCAGGGTATCGCCGTGGTCA	0.567000													39	10					0	0	1	0	0
TAAR6	319100	broad.mit.edu	37	6	132892203	132892203	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:132892203G>C	ENST00000275198.1	+	1	743	c.743G>C	c.(742-744)aGa>aCa	p.R248T		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	248						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TACAAAGCCAGAGTGGCCAGG	0.403000													12	23					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7909777	7909777	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:7909777G>A	ENST00000254854.4	+	4	1273	c.1123G>A	c.(1123-1125)Gga>Aga	p.G375R		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	375					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				ATGGGTGTCCGGAGCAGCTGT	0.662000													18	30					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19693574	19693574	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:19693574C>G	ENST00000438132.3	+	28	2704	c.2656C>G	c.(2656-2658)Ctt>Gtt	p.L886V	C16orf62_ENST00000417362.2_Missense_Mutation_p.L704V|C16orf62_ENST00000448695.1_Missense_Mutation_p.L647V|C16orf62_ENST00000543152.1_Missense_Mutation_p.L546V|C16orf62_ENST00000542263.1_Missense_Mutation_p.L793V|C16orf62_ENST00000251143.5_Missense_Mutation_p.L797V	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	797						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						GGTCCTGTTTCTTGTTCGAGA	0.478000													74	55					0	0	1	0	0
CCNYL1	151195	broad.mit.edu	37	2	208618330	208618330	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:208618330G>A	ENST00000295414.3	+	10	1199	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K	CCNYL1_ENST00000468768.1_3'UTR|CCNYL1_ENST00000392209.3_Missense_Mutation_p.E260K|CCNYL1_ENST00000339882.5_Missense_Mutation_p.E279K			Q8N7R7	CCYL1_HUMAN	cyclin Y-like 1	330					regulation of cyclin-dependent protein kinase activity		protein kinase binding			endometrium(1)|large_intestine(1)|lung(3)	5				LUSC - Lung squamous cell carcinoma(261;0.0731)|Epithelial(149;0.139)|Lung(261;0.14)		TAGATTGTGTGAAGACAAAGA	0.403000													37	111					0	0	1	0	0
NHLRC1	378884	broad.mit.edu	37	6	18122786	18122786	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:18122786C>T	ENST00000340650.3	-	1	65	c.52G>A	c.(52-54)Gag>Aag	p.E18K		NM_198586.2	NP_940988.2	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	18					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.E18*(1)		breast(1)|kidney(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(2)	11	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			ATCTCCGCCTCGCGCATGAGC	0.711000													128	17					0	0	1	0	0
LRP8	7804	broad.mit.edu	37	1	53792581	53792581	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:53792581C>T	ENST00000306052.6	-	2	309	c.208G>A	c.(208-210)Gat>Aat	p.D70N	LRP8_ENST00000354412.3_Missense_Mutation_p.D70N|LRP8_ENST00000465675.1_5'UTR|LRP8_ENST00000371454.2_Missense_Mutation_p.D70N|LRP8_ENST00000347547.2_Missense_Mutation_p.D70N	NM_004631.4	NP_004622.2	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	70	LDL-receptor class A 1.				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(1)	21						AAGCAGTCATCGTCCTCGTCG	0.642000													25	66					0	0	1	0	0
ZNF547	284306	broad.mit.edu	37	19	57888566	57888566	+	Silent	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:57888566C>A	ENST00000282282.3	+	4	372	c.222C>A	c.(220-222)gtC>gtA	p.V74V	AC003002.4_ENST00000597658.1_Intron	NM_173631.2	NP_775902.2	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	74	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGTCACAGGTCATGGCTCCAA	0.507000													18	27					5.03518e-11	5.31329e-11	1	1	0
GRIA1	2890	broad.mit.edu	37	5	153078545	153078545	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:153078545G>A	ENST00000285900.5	+	10	1707	c.1364G>A	c.(1363-1365)cGt>cAt	p.R455H	GRIA1_ENST00000518142.1_Missense_Mutation_p.R375H|GRIA1_ENST00000521843.2_Missense_Mutation_p.R386H|GRIA1_ENST00000448073.4_Missense_Mutation_p.R465H|GRIA1_ENST00000518783.1_Missense_Mutation_p.R465H|GRIA1_ENST00000340592.5_Missense_Mutation_p.R455H	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	455					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding	p.R455H(1)		NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TACTCCTACCGTCTGGAGATT	0.542000													7	17					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12317073	12317073	+	Silent	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:12317073C>G	ENST00000358136.3	+	9	1000	c.870C>G	c.(868-870)ctC>ctG	p.L290L	VPS13D_ENST00000356315.4_Silent_p.L290L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	290					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGGAATTCCTCAAGGAGCTGG	0.423000													25	77					0	0	1	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208795688	208795688	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:208795688G>A	ENST00000457206.1	-	5	2275	c.1848C>T	c.(1846-1848)ttC>ttT	p.F616F	PLEKHM3_ENST00000389247.4_Silent_p.F616F|PLEKHM3_ENST00000427836.2_Silent_p.F616F			Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M, member 3	616					intracellular signal transduction		metal ion binding	p.F616F(2)		central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCCGGCAGCTGAACAAATAGG	0.627000													42	30					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46914452	46914452	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:46914452C>T	ENST00000307522.3	-	1	2389	c.1616G>A	c.(1615-1617)tGa>tAa	p.*539*		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	0						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		GCCCTCACCTCACAGCTGGTC	0.632000													15	48					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49933651	49933651	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:49933651C>T	ENST00000296474.3	-	10	2653	c.2626G>A	c.(2626-2628)Gag>Aag	p.E876K	MST1R_ENST00000344206.4_Missense_Mutation_p.E876K	NM_002447.2	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	876					cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		GCATGCTCCTCAGGCTTCAGT	0.577000													43	11					0	0	1	0	0
ATG12	9140	broad.mit.edu	37	5	115168301	115168301	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:115168301C>T	ENST00000509910.1	-	3	666	c.361G>A	c.(361-363)Gag>Aag	p.E121K	ATG12_ENST00000500945.2_Silent_p.*75*|ATG12_ENST00000509598.1_5'UTR|ATG12_ENST00000274459.4_Missense_Mutation_p.E168K			O94817	ATG12_HUMAN	autophagy related 12	121					autophagic vacuole assembly|negative regulation of type I interferon production	pre-autophagosomal structure membrane	protein binding			endometrium(2)|kidney(1)|lung(1)|prostate(1)	5		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;7.59e-08)|Epithelial(69;7.05e-07)|all cancers(49;3.11e-05)		ttttttACCTCATAGAGAGTT	0.289000													10	13					0	0	1	0	0
ANKFY1	51479	broad.mit.edu	37	17	4074069	4074069	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:4074069G>A	ENST00000341657.4	-	23	3261	c.3226C>T	c.(3226-3228)Cag>Tag	p.Q1076*	ANKFY1_ENST00000570535.1_Nonsense_Mutation_p.Q1118*|ANKFY1_ENST00000574367.1_Nonsense_Mutation_p.Q1077*|CYB5D2_ENST00000573984.1_Intron	NM_016376.3	NP_057460.3	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	1076						endosome membrane	metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|liver(1)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						TTGACTCCCTGGTTGTTATTC	0.582000													47	6					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53450858	53450858	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:53450858G>C	ENST00000314250.6	+	11	1113	c.823G>C	c.(823-825)Gaa>Caa	p.E275Q	TENC1_ENST00000549700.1_Missense_Mutation_p.E275Q|TENC1_ENST00000451358.1_Missense_Mutation_p.E275Q|TENC1_ENST00000314276.3_Missense_Mutation_p.E285Q|TENC1_ENST00000379902.3_Missense_Mutation_p.E151Q|TENC1_ENST00000546602.1_Missense_Mutation_p.E275Q|TENC1_ENST00000552570.1_Missense_Mutation_p.E275Q	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	275	Phosphatase tensin-type.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						GGTGGCCACAGAACTGCAGCC	0.592000													9	1					0	0	1	0	0
NKX2-2	4821	broad.mit.edu	37	20	21494067	21494067	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr20:21494067C>T	ENST00000377142.4	-	1	597	c.241G>A	c.(241-243)Gag>Aag	p.E81K		NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	81					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						TGAAGGCCCTCGGTGCTGGCC	0.662000													12	16					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	153967640	153967640	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:153967640G>A	ENST00000368559.3	-	38	5474	c.5403C>T	c.(5401-5403)tcC>tcT	p.S1801S	NUP210L_ENST00000368553.1_Silent_p.S582S|NUP210L_ENST00000271854.3_Silent_p.S1649S	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	1801						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TGAGGATGGCGGAATCTTCAC	0.413000													12	39					0	0	1	0	0
TRDMT1	1787	broad.mit.edu	37	10	17210866	17210866	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:17210866C>T	ENST00000377799.3	-	3	272	c.225G>A	c.(223-225)atG>atA	p.M75I	TRDMT1_ENST00000377766.5_Intron|TRDMT1_ENST00000488990.1_Intron|TRDMT1_ENST00000452380.2_5'UTR|TRDMT1_ENST00000358282.7_Intron|TRDMT1_ENST00000412821.3_Missense_Mutation_p.M75I|TRDMT1_ENST00000457442.2_Intron|TRDMT1_ENST00000351358.4_Missense_Mutation_p.M75I	NM_004412.5	NP_004403.1	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1	75					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	18						AGGGAGGGCTCATTAAAATCA	0.383000													9	10					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508793	106508793	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:106508793G>A	ENST00000359195.3	+	2	1097	c.787G>A	c.(787-789)Gaa>Aaa	p.E263K	PIK3CG_ENST00000440650.2_Missense_Mutation_p.E263K|PIK3CG_ENST00000496166.1_Missense_Mutation_p.E263K	NM_001282427.1|NM_002649.2	NP_001269356.1|NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	263					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						GGATATTCCCGAAAGCCAAAG	0.557000													25	28					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40915746	40915746	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:40915746A>G	ENST00000346991.5	+	11	3752	c.3362A>G	c.(3361-3363)gAa>gGa	p.E1121G	CASC5_ENST00000399668.2_Missense_Mutation_p.E1095G			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	1121	2 X 104 AA approximate repeats.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TGTATGGTGGAAATAGATAAC	0.378000													44	10					0	0	1	0	0
COMMD5	28991	broad.mit.edu	37	8	146076538	146076538	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:146076538C>G	ENST00000450361.2	-	2	607	c.186G>C	c.(184-186)gaG>gaC	p.E62D	COMMD5_ENST00000402718.3_Missense_Mutation_p.E62D|COMMD5_ENST00000305103.3_Missense_Mutation_p.E62D	NM_001081003.1	NP_001074472.1	Q9GZQ3	COMD5_HUMAN	COMM domain containing 5	62						nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|ovary(1)|pancreas(1)	11	all_cancers(97;1.14e-11)|all_epithelial(106;7.74e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)			CTCGGCAGTCCTCCCCCTGCA	0.632000													18	30					0	0	1	0	0
ZNF274	10782	broad.mit.edu	37	19	58718134	58718134	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:58718134G>A	ENST00000326804.4	+	5	763	c.304G>A	c.(304-306)Gag>Aag	p.E102K	ZNF274_ENST00000345813.3_Missense_Mutation_p.E70K|ZNF274_ENST00000424679.2_5'UTR|ZNF274_ENST00000597818.1_3'UTR	NM_001278734.1|NM_133502.1	NP_001265663.1|NP_598009.1	Q96GC6	ZN274_HUMAN	zinc finger protein 274	102					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)|skin(1)	21		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		TCTTCCTGCTGAGAGTCCCCT	0.498000													5	9					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98742495	98742495	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:98742495G>A	ENST00000286067.2	+	1	1455	c.1348G>A	c.(1348-1350)Gaa>Aaa	p.E450K		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	450										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AAACCCCAGTGAAACTGAGGA	0.463000													78	92					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18155332	18155332	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:18155332G>A	ENST00000327031.4	-	11	1452	c.1227C>T	c.(1225-1227)acC>acT	p.T409T	FLII_ENST00000545457.2_Silent_p.T355T|FLII_ENST00000579294.1_Silent_p.T398T|FLII_ENST00000379450.4_Silent_p.T324T|FLII_ENST00000578558.1_Silent_p.T409T	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	409	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					CTGCAGCCACGGTAGCAGGAG	0.617000													4	70					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70450929	70450929	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr18:70450929G>A	ENST00000327305.6	-	7	1509	c.852C>T	c.(850-852)ttC>ttT	p.F284F	NETO1_ENST00000299430.2_Silent_p.F283F|NETO1_ENST00000583169.1_Silent_p.F284F	NM_138966.3	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	284	CUB 2.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GAAAGGATGTGAAGAGCATCT	0.453000													23	64					0	0	1	0	0
SSTR1	6751	broad.mit.edu	37	14	38679063	38679063	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:38679063G>A	ENST00000267377.2	+	3	1086	c.469G>A	c.(469-471)Gtg>Atg	p.V157M		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	157					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GGACCGCTACGTGGCCGTGGT	0.647000													16	53					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46914520	46914520	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:46914520C>T	ENST00000307522.3	-	1	2321	c.1548G>A	c.(1546-1548)agG>agA	p.R516R		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	516						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CCCTGAGGTTCCTGGCCTCTC	0.642000													9	33					0	0	1	0	0
DNAJB2	3300	broad.mit.edu	37	2	220149525	220149525	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:220149525C>T	ENST00000336576.5	+	9	1079	c.791C>T	c.(790-792)tCa>tTa	p.S264L	DNAJB2_ENST00000392086.4_Missense_Mutation_p.S264L|DNAJB2_ENST00000463463.1_3'UTR	NM_006736.5	NP_006727.2	P25686	DNJB2_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 2	264					ER-associated protein catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|negative regulation of protein deubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding|response to unfolded protein	inclusion body	heat shock protein binding|Hsp70 protein binding|polyubiquitin binding|proteasome binding|protein binding|unfolded protein binding			endometrium(4)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14		Renal(207;0.0474)		Epithelial(149;1.97e-06)|all cancers(144;0.00028)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TACAGCCTGTCAGAGATGGAG	0.667000													6	11					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16818204	16818204	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:16818204C>T	ENST00000513610.1	-	3	647	c.193G>A	c.(193-195)Gtg>Atg	p.V65M	MYO10_ENST00000507288.1_Missense_Mutation_p.V65M	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	65	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						ATGTCATCCACGCCCTCCTCG	0.468000													6	22					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56587357	56587357	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr18:56587357C>T	ENST00000336078.4	+	4	2614	c.1838C>T	c.(1837-1839)aCg>aTg	p.T613M	ZNF532_ENST00000591083.1_Missense_Mutation_p.T613M|ZNF532_ENST00000589288.1_Missense_Mutation_p.T613M|ZNF532_ENST00000591230.1_Missense_Mutation_p.T613M|ZNF532_ENST00000591808.1_Missense_Mutation_p.T613M	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	613					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						ACGTTACCGACGCGTGGGTAC	0.547000													7	32					0	0	1	0	0
GSTZ1	2954	broad.mit.edu	37	14	77793191	77793191	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:77793191G>C	ENST00000216465.5	+	3	363	c.78G>C	c.(76-78)ttG>ttC	p.L26F	GSTZ1_ENST00000393734.1_5'UTR|GSTZ1_ENST00000557053.1_5'UTR|GSTZ1_ENST00000557639.1_5'UTR|GSTZ1_ENST00000349555.3_Missense_Mutation_p.L26F|GSTZ1_ENST00000554279.1_Missense_Mutation_p.L26F|GSTZ1_ENST00000556627.1_Missense_Mutation_p.L26F|GSTZ1_ENST00000553586.1_Missense_Mutation_p.L27F|GSTZ1_ENST00000361389.4_5'UTR	NM_145870.2	NP_665877.1	O43708	MAAI_HUMAN	glutathione S-transferase zeta 1	26	GST N-terminal.				glutathione metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol|mitochondrion	glutathione peroxidase activity|glutathione transferase activity|maleylacetoacetate isomerase activity|protein homodimerization activity			lung(2)|prostate(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)	Glutathione(DB00143)	CTCTGGCCTTGAAAGGCATCG	0.527000													3	15					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5841757	5841757	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:5841757C>T	ENST00000317037.2	+	1	214	c.192C>T	c.(190-192)ttC>ttT	p.F64F	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTACTACTTCCTGGCCCTGC	0.512000													40	47					0	0	1	0	0
FTCD	10841	broad.mit.edu	37	21	47571574	47571574	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr21:47571574C>T	ENST00000397748.1	-	5	577	c.534G>A	c.(532-534)gcG>gcA	p.A178A	FTCD_ENST00000355384.2_Silent_p.A178A|FTCD-AS1_ENST00000446649.1_RNA|FTCD_ENST00000291670.5_Silent_p.A178A|FTCD_ENST00000397746.3_Silent_p.A178A|FTCD_ENST00000397743.1_Silent_p.A178A|FTCD_ENST00000498355.2_5'UTR|FTCD_ENST00000359679.2_Silent_p.A178A			O95954	FTCD_HUMAN	formimidoyltransferase cyclodeaminase	178	Formiminotransferase N-subdomain (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			endometrium(1)|large_intestine(2)|lung(9)|pancreas(1)|prostate(3)|skin(3)	19	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	GGAACTTCCTCGCCCCCGTGG	0.652000													70	14					0	0	1	0	0
EPS8L3	79574	broad.mit.edu	37	1	110301945	110301945	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:110301945G>C	ENST00000369805.3	-	5	549	c.320C>G	c.(319-321)tCc>tGc	p.S107C	RP4-735C1.4_ENST00000431955.1_RNA|EPS8L3_ENST00000361965.4_Missense_Mutation_p.S107C|EPS8L3_ENST00000494151.1_5'UTR|EPS8L3_ENST00000361852.4_Missense_Mutation_p.S107C	NM_139053.2	NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	107						cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		GGAGTTGTAGGAACATGTGTT	0.612000													31	101					0	0	1	0	0
ALX1	8092	broad.mit.edu	37	12	85674234	85674234	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:85674234G>C	ENST00000316824.3	+	1	350	c.195G>C	c.(193-195)ttG>ttC	p.L65F		NM_006982.2	NP_008913.2	Q15699	ALX1_HUMAN	ALX homeobox 1	65					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|ovary(1)	26				GBM - Glioblastoma multiforme(134;0.134)		ACGTGCGCTTGGAGAGGACCT	0.637000													19	11					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53451392	53451392	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:53451392G>C	ENST00000314250.6	+	12	1177	c.887G>C	c.(886-888)aGa>aCa	p.R296T	TENC1_ENST00000549700.1_Missense_Mutation_p.R296T|TENC1_ENST00000451358.1_Missense_Mutation_p.R296T|TENC1_ENST00000314276.3_Missense_Mutation_p.R306T|TENC1_ENST00000379902.3_Missense_Mutation_p.R172T|TENC1_ENST00000546602.1_Missense_Mutation_p.R296T|TENC1_ENST00000552570.1_Missense_Mutation_p.R296T	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	296					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						GGCTCCATCAGAATGAACAGC	0.532000													149	33					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159655130	159655130	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:159655130C>T	ENST00000297267.9	+	11	3786	c.3586C>T	c.(3586-3588)Ctg>Ttg	p.L1196L	FNDC1_ENST00000340366.6_Silent_p.L1133L	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1196						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGAAGACCTTCTGTCTTCCTC	0.617000													6	10					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180065277	180065277	+	Nonsense_Mutation	SNP	T	T	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:180065277T>A	ENST00000367607.3	+	36	9442	c.9024T>A	c.(9022-9024)taT>taA	p.Y3008*	CEP350_ENST00000490141.1_3'UTR	NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	3008						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						ACTCTAGTTATTTCCGACGAG	0.328000													3	4					0	0	1	0	0
CENPH	64946	broad.mit.edu	37	5	68487627	68487627	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:68487627G>C	ENST00000283006.2	+	2	227	c.140G>C	c.(139-141)aGa>aCa	p.R47T	CENPH_ENST00000515001.1_Missense_Mutation_p.R47T	NM_022909.3	NP_075060.1	Q9H3R5	CENPH_HUMAN	centromere protein H	47					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|kinetochore organization|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	kinetochore binding|protein binding			kidney(15)|large_intestine(2)|lung(3)	20		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.41e-56)|Epithelial(20;1.29e-52)|all cancers(19;3.15e-48)|Lung(70;0.0178)		TTCAGGCTGAGAGCACAGACA	0.308000													23	22					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97311455	97311455	+	Splice_Site	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:97311455G>T	ENST00000389672.5	+	12	2424		c.e12-1		EPHA6_ENST00000442602.2_Splice_Site|EPHA6_ENST00000514100.1_Splice_Site|EPHA6_ENST00000502694.1_Splice_Site	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6							integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						TCTCTTAAAAGGATCCTTCCC	0.433000													31	46					2.48696e-23	2.72739e-23	1	1	0
BRMS1	25855	broad.mit.edu	37	11	66108769	66108769	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:66108769C>T	ENST00000359957.3	-	4	426	c.266G>A	c.(265-267)cGg>cAg	p.R89Q	BRMS1_ENST00000425825.2_Missense_Mutation_p.R89Q	NM_015399.3	NP_056214.1	Q9HCU9	BRMS1_HUMAN	breast cancer metastasis suppressor 1	89					apoptosis|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of anoikis|positive regulation of protein deacetylation|transcription, DNA-dependent	cytoplasm|nucleus	NF-kappaB binding			large_intestine(1)|liver(1)|lung(1)|prostate(1)|skin(1)	5						TTCCTCCAGCCGCAACCGCAG	0.602000													7	16					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62330175	62330175	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:62330175C>A	ENST00000371158.2	+	20	2819	c.2705C>A	c.(2704-2706)tCt>tAt	p.S902Y	INADL_ENST00000316485.6_Missense_Mutation_p.S902Y	NM_176877.2	NP_795352	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	902					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CCTGTGCCCTCTGTGAATGAA	0.463000													32	65					1.30293e-26	1.44638e-26	1	1	0
KCNJ10	3766	broad.mit.edu	37	1	160011440	160011440	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:160011440G>C	ENST00000368089.3	-	2	1109	c.883C>G	c.(883-885)Cag>Gag	p.Q295E	KCNJ10_ENST00000509700.1_Intron	NM_002241.4	NP_002232.2	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 10	295						integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)	17	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGCGCACCTGACAGGTGGCA	0.542000													16	12					0	0	1	0	0
FOXA3	3171	broad.mit.edu	37	19	46375735	46375735	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:46375735C>T	ENST00000302177.2	+	2	669	c.472C>T	c.(472-474)Cag>Tag	p.Q158*		NM_004497.2	NP_004488.2	P55318	FOXA3_HUMAN	forkhead box A3	158					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	13		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		CCGGGAGAATCAGCAGCGCTG	0.572000													24	73					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109859108	109859108	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr13:109859108A>C	ENST00000356711.2	+	35	5627	c.5501A>C	c.(5500-5502)aAg>aCg	p.K1834T	MYO16_ENST00000357550.2_Missense_Mutation_p.K1834T	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1834					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCTTGCAAGAAGCCCAGCCTT	0.592000													13	18					0	0	1	0	0
DPH2	1802	broad.mit.edu	37	1	44437342	44437342	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:44437342G>A	ENST00000255108.3	+	4	940	c.768G>A	c.(766-768)aaG>aaA	p.K256K	DPH2_ENST00000412950.2_Silent_p.K121K|DPH2_ENST00000396758.2_Intron|DPH2_ENST00000529729.1_3'UTR	NM_001384.4	NP_001375.2	Q9BQC3	DPH2_HUMAN	DPH2 homolog (S. cerevisiae)	256					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(2)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				ATACAGGGAAGACTCAGGATG	0.632000													18	20					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62025423	62025423	+	Splice_Site	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:62025423C>T	ENST00000435607.1	-	17	3221	c.3145G>A	c.(3145-3147)Gcc>Acc	p.A1049T	SCN4A_ENST00000578147.1_Splice_Site_p.A1049T	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1049					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TCCTCGAAGGCCTGGGGGCAC	0.612000													14	19					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59404265	59404265	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:59404265G>A	ENST00000301645.3	-	6	1421	c.1284C>T	c.(1282-1284)ctC>ctT	p.L428L		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	428					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding	p.L428L(1)		breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				ACTTTAACTTGAGTCCATTAC	0.358000									Neonatal Giant Cell Hepatitis				49	193					0	0	1	0	0
OR4X2	119764	broad.mit.edu	37	11	48267376	48267376	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:48267376T>G	ENST00000302329.3	+	1	769	c.721T>G	c.(721-723)Ttg>Gtg	p.L241V		NM_001004727.1	NP_001004727.1	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X, member 2	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(4)|lung(12)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	20						TGTGGTTATCTTGTTCTTTGG	0.522000													21	14					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89349928	89349928	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr16:89349928C>G	ENST00000301030.4	-	9	3482	c.3022G>C	c.(3022-3024)Gag>Cag	p.E1008Q	ANKRD11_ENST00000378330.2_Missense_Mutation_p.E1008Q	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1008	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTCTCCTTCTCTCGTGCTGGG	0.532000													30	56					0	0	1	0	0
FOXN1	8456	broad.mit.edu	37	17	26864385	26864385	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:26864385G>A	ENST00000226247.2	+	8	1907	c.1878G>A	c.(1876-1878)acG>acA	p.T626T	FOXN1_ENST00000579795.1_Silent_p.T626T	NM_003593.2	NP_003584.2	O15353	FOXN1_HUMAN	forkhead box N1	626					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Lung NSC(42;0.00431)					TGGAGCCCACGCCCCCCACGG	0.682000													11	35					0	0	1	0	0
RUNX1	861	broad.mit.edu	37	21	36259204	36259204	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr21:36259204T>C	ENST00000344691.4	-	1	1783	c.206A>G	c.(205-207)aAc>aGc	p.N69S	RUNX1_ENST00000358356.5_Missense_Mutation_p.N69S|RUNX1_ENST00000325074.5_Missense_Mutation_p.N84S|RUNX1_ENST00000437180.1_Missense_Mutation_p.N96S|RUNX1_ENST00000300305.3_Missense_Mutation_p.N96S|RUNX1_ENST00000399240.1_Missense_Mutation_p.N69S|RUNX1_ENST00000486278.2_Missense_Mutation_p.N72S	NM_001001890.2	NP_001001890.1	Q01196	RUNX1_HUMAN	runt-related transcription factor 1	69	Runt.				myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|calcium ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.V90_K117del(1)		breast(5)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(428)|large_intestine(3)|lung(6)|oesophagus(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	452						GCAGAGGAAGTTGGGGCTGTC	0.701000			T	"""RPL22, MDS1, EVI1, CBFA2T3, CBFA2T1, ETV6, LAF4"""	"""AML, preB- ALL, T-ALL"""								24	12					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110986227	110986227	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:110986227G>A	ENST00000524391.1	-	2	1423	c.391C>T	c.(391-393)Ctc>Ttc	p.L131F	KCNV1_ENST00000297404.1_Missense_Mutation_p.L131F|RP11-696P8.2_ENST00000530667.1_RNA			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	131						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			AGGAAGGAGAGCGCGCACAGC	0.637000													11	26					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr9:20414346G>A	ENST00000380338.4	-	5	784	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S163S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								4	39					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115838018	115838018	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:115838018T>C	ENST00000343348.6	-	3	893	c.106A>G	c.(106-108)Aaa>Gaa	p.K36E	SEMA6A_ENST00000510263.1_Missense_Mutation_p.K36E|SEMA6A_ENST00000503962.1_5'UTR|SEMA6A_ENST00000257414.8_Missense_Mutation_p.K36E|CTB-118N6.3_ENST00000510682.1_RNA	NM_020796.3	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	36	Sema.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		GGATACTGTTTTGTATCTGTG	0.498000													26	35					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088427	94088427	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:94088427G>A	ENST00000553484.1	+	31	5068	c.4914G>A	c.(4912-4914)tcG>tcA	p.S1638S	UNC79_ENST00000555664.1_Silent_p.S1616S|UNC79_ENST00000393151.2_Silent_p.S1616S|UNC79_ENST00000256339.4_Silent_p.S1439S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1616						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						ATTCAACCTCGGGGCCTGAAA	0.468000													26	67					0	0	1	0	0
SLC22A13	9390	broad.mit.edu	37	3	38307727	38307727	+	Missense_Mutation	SNP	G	G	A	rs147778100		TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:38307727G>A	ENST00000311856.4	+	1	425	c.376G>A	c.(376-378)Gag>Aag	p.E126K	SLC22A13_ENST00000450935.2_Missense_Mutation_p.E85K	NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	126						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		CCTGAAGAATGAGGTAGGCTT	0.562000													13	44					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31369187	31369187	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr20:31369187G>C	ENST00000328111.2	+	3	492	c.171G>C	c.(169-171)aaG>aaC	p.K57N	DNMT3B_ENST00000353855.2_Missense_Mutation_p.K57N|DNMT3B_ENST00000201963.3_Missense_Mutation_p.K69N|DNMT3B_ENST00000348286.2_Missense_Mutation_p.K57N|DNMT3B_ENST00000344505.4_Missense_Mutation_p.K57N|DNMT3B_ENST00000375623.4_Missense_Mutation_p.K57N|DNMT3B_ENST00000443239.3_Missense_Mutation_p.K57N|DNMT3B_ENST00000456297.2_Missense_Mutation_p.K57N	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	57	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GACTCTCCAAGAGGGAGGTGT	0.552000													10	38					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47504396	47504396	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:47504396G>C	ENST00000371901.3	+	7	1090	c.840G>C	c.(838-840)aaG>aaC	p.K280N	CYP4X1_ENST00000538609.1_Missense_Mutation_p.K279N|CYP4X1_ENST00000466294.1_3'UTR	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	280						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						ACACTCCGAAGAGGAAGTACC	0.393000													26	22					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111535718	111535718	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:111535718C>G	ENST00000428084.1	-	16	1809	c.1537G>C	c.(1537-1539)Gaa>Caa	p.E513Q	DOCK4_ENST00000476846.1_5'UTR|DOCK4_ENST00000437633.1_Missense_Mutation_p.E513Q			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	513	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				CTACCATCTTCTTGCATCAGA	0.403000													51	117					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169814608	169814608	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:169814608C>T	ENST00000263817.6	-	19	2333	c.2209G>A	c.(2209-2211)Gaa>Aaa	p.E737K		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	737					bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GGGGCAGGTTCAACTTCTTCC	0.483000													14	39					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228447433	228447433	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:228447433G>A	ENST00000570156.2	+	17	5167	c.5093G>A	c.(5092-5094)tGt>tAt	p.C1698Y	OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000359599.6_Missense_Mutation_p.C170Y|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000284548.11_Intron	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	684	Ig-like 17.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GAGTATAGCTGTGAGGCTGGG	0.587000													18	62					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1921097	1921097	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:1921097C>G	ENST00000399161.2	-	11	2245	c.1498G>C	c.(1498-1500)Gaa>Caa	p.E500Q	MYT1L_ENST00000428368.2_Missense_Mutation_p.E498Q	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	500					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E500K(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCTTTCTTTTCTGTTCTTGAG	0.478000													16	95					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155191082	155191082	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr4:155191082C>T	ENST00000357232.4	-	19	5181	c.5182G>A	c.(5182-5184)Gat>Aat	p.D1728N		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AGAACTCCATCTTCATTTCCA	0.343000													35	24					0	0	1	0	0
CTD-2090I13.1	0	broad.mit.edu	37	1	227618266	227618266	+	RNA	SNP	C	C	T	rs140531650	by1000genomes	TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:227618266C>T	ENST00000445817.1	+	0	1501																											GCATATTCTGCGAGTACTCAA	0.507000													16	19					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605048	140605048	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:140605048G>A	ENST00000239449.4	+	1	1971	c.1971G>A	c.(1969-1971)acG>acA	p.T657T	PCDHB14_ENST00000515856.2_Silent_p.T504T	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		657	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCACCGCCACGCTGCACGTGC	0.721000													27	35					0	0	1	0	0
RIC3	79608	broad.mit.edu	37	11	8158946	8158946	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:8158946C>T	ENST00000343202.4	-	4	565	c.500G>A	c.(499-501)aGa>aAa	p.R167K	RIC3_ENST00000530060.1_5'UTR|RIC3_ENST00000335425.7_Intron|RIC3_ENST00000309737.6_Missense_Mutation_p.R167K|RIC3_ENST00000425599.2_Intron|RIC3_ENST00000539720.1_Missense_Mutation_p.R118K	NM_001206671.2|NM_024557.4	NP_001193600.1|NP_078833.3	Q7Z5B4	RIC3_HUMAN	RIC3 acetylcholine receptor chaperone	167						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)	17				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		AGGTCCCACTCTGTTGATTAA	0.423000													64	11					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6553157	6553157	+	Splice_Site	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:6553157C>T	ENST00000263125.5	-	3	218		c.e3-1		PRKCQ_ENST00000397176.2_Splice_Site|PRKCQ_ENST00000539722.1_Splice_Site	NM_001282644.1|NM_006257.3	NP_001269573.1|NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta						axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						TGCCCGTTCTCTAGGAACAGA	0.463000													17	35					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89649709	89649709	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr4:89649709C>G	ENST00000264344.5	-	24	3254	c.3047G>C	c.(3046-3048)aGa>aCa	p.R1016T	FAM13A_ENST00000511976.1_Missense_Mutation_p.R602T|FAM13A_ENST00000508369.1_Missense_Mutation_p.R690T|FAM13A_ENST00000503556.1_Missense_Mutation_p.R676T|FAM13A-AS1_ENST00000511543.1_RNA|FAM13A_ENST00000395002.2_Missense_Mutation_p.R662T|FAM13A_ENST00000513837.1_Missense_Mutation_p.R662T|FAM13A-AS1_ENST00000500765.1_RNA	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	1016					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						ATCAGTGTCTCTCTTGCTGAT	0.522000													15	31					0	0	1	0	0
KCNIP3	30818	broad.mit.edu	37	2	96040659	96040659	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:96040659C>G	ENST00000295225.5	+	4	505	c.370C>G	c.(370-372)Cag>Gag	p.Q124E	KCNIP3_ENST00000468529.1_Missense_Mutation_p.Q98E|KCNIP3_ENST00000360990.3_Intron|KCNIP3_ENST00000377181.2_3'UTR	NM_013434.4	NP_038462.1	Q9Y2W7	CSEN_HUMAN	Kv channel interacting protein 3, calsenilin	124					apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	16				READ - Rectum adenocarcinoma(193;0.13)		GTTCTTCCCTCAGGGAGGTGA	0.652000													27	30					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35667227	35667227	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:35667227G>C	ENST00000440995.2	+	9	1221	c.1221G>C	c.(1219-1221)aaG>aaC	p.K407N	SPEF2_ENST00000282469.6_Missense_Mutation_p.K407N|SPEF2_ENST00000509059.1_Missense_Mutation_p.K407N|SPEF2_ENST00000356031.3_Missense_Mutation_p.K407N			Q9C093	SPEF2_HUMAN	sperm flagellar 2	407					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTAAAGAAAAGAGATTTCATG	0.318000													20	39					0	0	1	0	0
FAM135A	57579	broad.mit.edu	37	6	71246060	71246060	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:71246060C>G	ENST00000418814.2	+	19	4677	c.4063C>G	c.(4063-4065)Ctt>Gtt	p.L1355V	FAM135A_ENST00000505769.1_Missense_Mutation_p.L935V|FAM135A_ENST00000370479.3_Missense_Mutation_p.L1142V|FAM135A_ENST00000361499.3_Missense_Mutation_p.L1159V|FAM135A_ENST00000505868.1_Missense_Mutation_p.L1355V|FAM135A_ENST00000457062.2_Missense_Mutation_p.L1142V	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	1355										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						CTTTCTGTCTCTTTCTGGACC	0.353000													23	8					0	0	1	0	0
PRR5L	79899	broad.mit.edu	37	11	36440835	36440835	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:36440835C>A	ENST00000378867.3	+	5	631	c.276C>A	c.(274-276)ttC>ttA	p.F92L	PRR5L_ENST00000530639.1_Missense_Mutation_p.F92L|PRR5L_ENST00000389693.3_3'UTR|PRR5L_ENST00000527487.1_Missense_Mutation_p.F92L|PRR5L_ENST00000311599.5_Missense_Mutation_p.F66L	NM_024841.4	NP_079117.3	Q6MZQ0	PRR5L_HUMAN	proline rich 5 like	92										breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(7)|ovary(1)	19						TTGGATCATTCATTACAGACT	0.483000													21	36					1.64293e-13	1.75407e-13	1	1	0
RBP2	5948	broad.mit.edu	37	3	139195287	139195287	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:139195287C>G	ENST00000232217.2	-	1	71	c.15G>C	c.(13-15)caG>caC	p.Q5H	RP11-319G6.1_ENST00000515247.1_RNA	NM_004164.2	NP_004155.2	P50120	RET2_HUMAN	retinol binding protein 2, cellular	5					epidermis development|retinoid metabolic process|steroid metabolic process|vitamin A metabolic process	cytosol	retinal binding|retinol binding|transporter activity			breast(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12					Vitamin A(DB00162)	AGGTTCCATTCTGGTCCCTTG	0.537000													36	26					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48808101	48808101	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:48808101C>T	ENST00000309835.3	+	1	339	c.329C>T	c.(328-330)tCa>tTa	p.S110L	STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.S110L|STON1_ENST00000404752.1_Missense_Mutation_p.S110L|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.S110L|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.S110L|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.S110L|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.S110L|STON1_ENST00000406226.1_Missense_Mutation_p.S110L					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GAATCATCTTCAGACAGCCCA	0.468000													32	52					0	0	1	0	0
ULK2	9706	broad.mit.edu	37	17	19685274	19685274	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:19685274G>C	ENST00000395544.4	-	23	3066	c.2567C>G	c.(2566-2568)tCt>tGt	p.S856C	ULK2_ENST00000361658.2_Missense_Mutation_p.S856C	NM_014683.3	NP_055498.3	Q8IYT8	ULK2_HUMAN	unc-51 like autophagy activating kinase 2	856					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|skin(4)|stomach(1)	6	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GGACACAGCAGATGTGCACAG	0.542000													20	63					0	0	1	0	0
ITPRIPL1	150771	broad.mit.edu	37	2	96993457	96993457	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:96993457C>G	ENST00000361124.4	+	1	1523	c.1112C>G	c.(1111-1113)tCa>tGa	p.S371*	ITPRIPL1_ENST00000542887.1_Nonsense_Mutation_p.S355*|ITPRIPL1_ENST00000536814.1_Nonsense_Mutation_p.S355*|ITPRIPL1_ENST00000439118.2_Nonsense_Mutation_p.S363*	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	363						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CGCTTTCTCTCAATCCACTTG	0.582000													33	103					0	0	1	0	0
CLIP1	6249	broad.mit.edu	37	12	122862358	122862358	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:122862358C>T	ENST00000358808.2	-	3	389	c.235G>A	c.(235-237)Gaa>Aaa	p.E79K	CLIP1_ENST00000302528.7_Missense_Mutation_p.E79K|CLIP1_ENST00000540338.1_Missense_Mutation_p.E79K|CLIP1_ENST00000361654.4_Missense_Mutation_p.E79K|CLIP1_ENST00000537178.1_Missense_Mutation_p.E79K	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	79	CAP-Gly 1.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		AACTGGGTTTCTCCAAGAAAC	0.478000													59	122					0	0	1	0	0
CASP2	835	broad.mit.edu	37	7	142988768	142988768	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:142988768G>A	ENST00000310447.5	+	2	451	c.210G>A	c.(208-210)atG>atA	p.M70I	CASP2_ENST00000493642.1_3'UTR|CASP2_ENST00000392925.2_Missense_Mutation_p.M70I	NM_032982.3|NM_032983.3	NP_116764.2|NP_116765.2	P42575	CASP2_HUMAN	caspase 2, apoptosis-related cysteine peptidase	70	CARD.				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(164;0.059)					CCTTGGAAATGAGGGAGCTCA	0.428000													58	55					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41568620	41568620	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr22:41568620G>A	ENST00000263253.7	+	28	5789	c.4570G>A	c.(4570-4572)Gaa>Aaa	p.E1524K	RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1524	Poly-Glu.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						GGAACAGGAGGAAGAAGAGAG	0.383000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				16	13					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49932965	49932965	+	Silent	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:49932965C>G	ENST00000296474.3	-	13	3006	c.2979G>C	c.(2977-2979)ctG>ctC	p.L993L	MST1R_ENST00000344206.4_Silent_p.L944L	NM_002447.2	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	993					cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CCAGGTCATTCAGGTTGGGAG	0.567000													25	6					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160059241	160059241	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:160059241C>T	ENST00000327245.5	-	13	2361	c.1515G>A	c.(1513-1515)ctG>ctA	p.L505L	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	505					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGCTCCTCCTCAGAGGCTGAG	0.587000													13	13					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89395057	89395057	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:89395057G>C	ENST00000439576.2	+	11	2433	c.2059G>C	c.(2059-2061)Gag>Cag	p.E687Q	ACAN_ENST00000352105.7_Missense_Mutation_p.E687Q|ACAN_ENST00000561243.1_Missense_Mutation_p.E687Q|ACAN_ENST00000559004.1_Missense_Mutation_p.E687Q	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	687					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGGAGAAGAAGAGGGTGGCAC	0.577000													3	7					0	0	1	0	0
WBP2NL	164684	broad.mit.edu	37	22	42415321	42415321	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr22:42415321G>C	ENST00000328823.9	+	2	100	c.69G>C	c.(67-69)ttG>ttC	p.L23F		NM_152613.2	NP_689826.2	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	23					egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			breast(2)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)	14						ACAGTCTCTTGAAGCGGTCTC	0.388000													59	12					0	0	1	0	0
IPO4	79711	broad.mit.edu	37	14	24651013	24651013	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:24651013G>A	ENST00000354464.6	-	27	3020	c.2844C>T	c.(2842-2844)ctC>ctT	p.L948L	RP11-468E2.2_ENST00000561419.1_3'UTR	NM_024658.3	NP_078934.3	Q8TEX9	IPO4_HUMAN	importin 4	948					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|stomach(2)|urinary_tract(1)	33				GBM - Glioblastoma multiforme(265;0.0087)		CCCGCGCCAGGAGGGGAAAAA	0.622000													11	29					0	0	1	0	0
KLC1	3831	broad.mit.edu	37	14	104120961	104120961	+	Silent	SNP	A	A	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:104120961A>G	ENST00000389744.4	+	2	329	c.60A>G	c.(58-60)acA>acG	p.T20T	KLC1_ENST00000334553.6_Silent_p.T20T|KLC1_ENST00000557450.1_Silent_p.T20T|RP11-73M18.2_ENST00000472726.2_Silent_p.T192T|KLC1_ENST00000553286.1_Silent_p.T20T|KLC1_ENST00000555836.1_Silent_p.T20T|KLC1_ENST00000380038.3_Silent_p.T20T|KLC1_ENST00000554280.1_Silent_p.T20T|KLC1_ENST00000557575.1_Silent_p.T20T|KLC1_ENST00000445352.4_Silent_p.T20T|KLC1_ENST00000347839.6_Silent_p.T20T|KLC1_ENST00000246489.7_Silent_p.T20T|KLC1_ENST00000452929.2_Silent_p.T20T|KLC1_ENST00000348520.6_Silent_p.T20T			Q07866	KLC1_HUMAN	kinesin light chain 1	20					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding		KLC1/ALK(2)	NS(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	12		Melanoma(154;0.155)|all_epithelial(191;0.19)				AGAAGCTTACACAGGATGAAA	0.363000													37	35					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92985372	92985372	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:92985372C>T	ENST00000544910.1	+	28	2885	c.2665C>T	c.(2665-2667)Cgg>Tgg	p.R889W	CCDC132_ENST00000541136.1_3'UTR|CCDC132_ENST00000305866.5_Missense_Mutation_p.R919W|CCDC132_ENST00000474412.1_3'UTR|CCDC132_ENST00000535481.1_Missense_Mutation_p.R639W	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	919										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TGACATGGAACGGTGGATCAA	0.318000													3	37					0	0	1	0	0
APOBEC3A	200315	broad.mit.edu	37	22	39355629	39355629	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr22:39355629G>A	ENST00000402255.1	+	3	316	c.112G>A	c.(112-114)Gag>Aag	p.E38K	APOBEC3A_ENST00000249116.2_Missense_Mutation_p.E38K					apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A											large_intestine(1)|lung(2)|ovary(1)|skin(1)	5	Melanoma(58;0.04)					CTACGAAGTGGAGCGCCTGGA	0.542000													41	10					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116535411	116535411	+	Splice_Site	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:116535411G>T	ENST00000410059.1	+	15	1841		c.e15+1		DPP10_ENST00000409163.1_Splice_Site|DPP10_ENST00000393147.2_Splice_Site|DPP10_ENST00000310323.8_Splice_Site	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)						proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						AGCTGTACAGGTAAGCAGTGT	0.398000													19	36					4.63292e-17	5.00521e-17	1	1	0
RRNAD1	51093	broad.mit.edu	37	1	156703213	156703213	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:156703213G>A	ENST00000368216.4	+	5	1167	c.537G>A	c.(535-537)gtG>gtA	p.V179V	RRNAD1_ENST00000368218.4_Silent_p.V179V|RRNAD1_ENST00000476229.1_Silent_p.V56V	NM_015997.3	NP_057081.3	Q96FB5	RRNAD_HUMAN	ribosomal RNA adenine dimethylase domain containing 1	179						integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(3)	9						GGTTGATGGTGAAGAGCATCG	0.592000													22	68					0	0	1	0	0
PRR21	643905	broad.mit.edu	37	2	240981281	240981281	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:240981281G>A	ENST00000408934.1	-	1	1118	c.1119C>T	c.(1117-1119)ttC>ttT	p.F373F		NM_001080835.1	NP_001074304.1	Q8WXC7	PRR21_HUMAN	proline rich 21	373										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(5)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	29						GACAGGTGTTGAAGGTGGCCC	0.463000													37	20					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35801453	35801453	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:35801453G>A	ENST00000361922.4	+	9	1673	c.1523G>A	c.(1522-1524)cGa>cAa	p.R508Q	MAG_ENST00000593348.1_3'UTR|MAG_ENST00000392213.3_Missense_Mutation_p.R508Q|MAG_ENST00000537831.2_Missense_Mutation_p.R483Q	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	508	Ig-like C2-type 4.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TCCTCAGATCGACTGATGTGG	0.562000													10	20					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070991	9070991	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:9070991C>T	ENST00000397910.4	-	3	16658	c.16455G>A	c.(16453-16455)ctG>ctA	p.L5485L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5487	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTAGGGCTCAGGGATGCTG	0.488000													7	40					0	0	1	0	0
FAM111A	63901	broad.mit.edu	37	11	58919728	58919728	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:58919728G>A	ENST00000528737.1	+	5	3405	c.587G>A	c.(586-588)aGa>aAa	p.R196K	FAM111A_ENST00000420244.1_Missense_Mutation_p.R196K|FAM111A_ENST00000533703.1_Missense_Mutation_p.R196K|FAM111A_ENST00000361723.3_Missense_Mutation_p.R196K|FAM111A_ENST00000531147.1_Missense_Mutation_p.R196K			Q96PZ2	F111A_HUMAN	family with sequence similarity 111, member A	196					proteolysis		serine-type endopeptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_epithelial(135;0.139)				AAGTGTAAAAGAAGGATTGTT	0.413000													24	45					0	0	1	0	0
ZNF829	374899	broad.mit.edu	37	19	37382438	37382438	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:37382438T>G	ENST00000520965.1	-	6	1564	c.1498A>C	c.(1498-1500)Agt>Cgt	p.S500R	ZNF345_ENST00000526123.1_Intron|ZNF829_ENST00000391711.3_Missense_Mutation_p.S419R|ZNF345_ENST00000432005.2_Intron	NM_001171979.1	NP_001165450.1	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCAGAGCGACTACCAAAAGCC	0.383000													8	66					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49791066	49791066	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:49791066G>T	ENST00000249601.4	-	2	462	c.166C>A	c.(166-168)Cag>Aag	p.Q56K	ARHGAP22_ENST00000491108.1_5'UTR|ARHGAP22_ENST00000435790.2_Missense_Mutation_p.Q62K|ARHGAP22_ENST00000417912.2_Missense_Mutation_p.Q56K	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	56	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						AACCAGCGCTGCTGCCAGTTC	0.612000													31	52					1.08312e-15	1.16668e-15	1	1	0
PCDHGA5	56110	broad.mit.edu	37	5	140744048	140744048	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:140744048G>C	ENST00000518069.1	+	1	151	c.151G>C	c.(151-153)Gac>Cac	p.D51H	PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATAGCCAAGGACCTTGGGCT	0.647000													22	27					0	0	1	0	0
FDXACB1	91893	broad.mit.edu	37	11	111746689	111746689	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:111746689G>A	ENST00000260257.4	-	5	879	c.832C>T	c.(832-834)Cct>Tct	p.P278S	ALG9_ENST00000527377.1_5'UTR|FDXACB1_ENST00000542429.1_Missense_Mutation_p.P129S|ALG9_ENST00000524880.1_Intron	NM_138378.2	NP_612387.1	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain containing 1	278					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(3)	19						TTCCAGAAAGGAAGAACACTG	0.428000													17	29					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105353177	105353177	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:105353177G>C	ENST00000453495.1	+	12	2832	c.2604G>C	c.(2602-2604)gaG>gaC	p.E868D	CEP170B_ENST00000418279.1_Missense_Mutation_p.E797D|CEP170B_ENST00000414716.3_Missense_Mutation_p.E867D|CEP170B_ENST00000556508.1_Missense_Mutation_p.E797D					centrosomal protein 170B																		TCCGGCAAGAGAGCTTCACTA	0.662000													10	21					0	0	1	0	0
FIGNL1	63979	broad.mit.edu	37	7	50514656	50514656	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:50514656G>A	ENST00000419119.1	-	2	1883	c.330C>T	c.(328-330)ttC>ttT	p.F110F	FIGNL1_ENST00000433017.1_Silent_p.F110F|FIGNL1_ENST00000435566.1_3'UTR|FIGNL1_ENST00000395556.2_Silent_p.F110F|FIGNL1_ENST00000356889.4_Silent_p.F110F			Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	110					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	29	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				TACTCATTTTGAAAACATTAT	0.383000													29	36					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70486786	70486786	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:70486786G>A	ENST00000310961.5	+	17	1838	c.1420G>A	c.(1420-1422)Gat>Aat	p.D474N	RP11-181B18.1_ENST00000425754.1_RNA|LRRC7_ENST00000415775.2_De_novo_Start_InFrame|LRRC7_ENST00000035383.5_Missense_Mutation_p.D469N|RP11-181B18.1_ENST00000414132.1_RNA			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	469						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CAAAAAAGAAGATGACGAAAA	0.383000													24	57					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32035481	32035481	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:32035481G>A	ENST00000375244.3	-	18	6702	c.6501C>T	c.(6499-6501)caC>caT	p.H2167H	TNXB_ENST00000375247.2_Silent_p.H2167H			P22105	TENX_HUMAN	tenascin XB	2239	Fibronectin type-III 14.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCCGCCCCTCGTGGAGGCCGT	0.672000													12	22					0	0	1	0	0
NBN	4683	broad.mit.edu	37	8	90967773	90967773	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:90967773C>T	ENST00000265433.3	-	10	1289	c.1135G>A	c.(1135-1137)Gaa>Aaa	p.E379K	NBN_ENST00000409330.1_Missense_Mutation_p.E297K	NM_002485.4	NP_002476.2	O60934	NBN_HUMAN	nibrin	379					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TTTGGCCTTTCACTCAAATCC	0.338000								Homologous recombination					9	72					0	0	1	0	0
WWC3	55841	broad.mit.edu	37	X	10106890	10106890	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chrX:10106890G>C	ENST00000380861.4	+	21	3389	c.2998G>C	c.(2998-3000)Gcc>Ccc	p.A1000P	WWC3_ENST00000454666.1_Missense_Mutation_p.A1000P	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	1000										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						GTTGGAGGACGCCCAGCTCCG	0.701000													9	5					0	0	1	0	0
APOBEC3A	200315	broad.mit.edu	37	22	39355623	39355623	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr22:39355623G>A	ENST00000402255.1	+	3	310	c.106G>A	c.(106-108)Gaa>Aaa	p.E36K	APOBEC3A_ENST00000249116.2_Missense_Mutation_p.E36K					apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A											large_intestine(1)|lung(2)|ovary(1)|skin(1)	5	Melanoma(58;0.04)					CCTGTGCTACGAAGTGGAGCG	0.537000													44	10					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7480927	7480927	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:7480927C>G	ENST00000399422.4	+	13	1749	c.1701C>G	c.(1699-1701)atC>atG	p.I567M		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	567					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						CTGGGAAAATCAAACGCAACG	0.373000													10	2					0	0	1	0	0
LRGUK	136332	broad.mit.edu	37	7	133884061	133884061	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:133884061G>A	ENST00000285928.2	+	14	1704	c.1635G>A	c.(1633-1635)cgG>cgA	p.R545R		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	545	Guanylate kinase-like.						ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						GATATTTGCGGAGAAAAGGAT	0.368000													35	103					0	0	1	0	0
CTAGE9	643854	broad.mit.edu	37	6	132030916	132030916	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:132030916C>T	ENST00000314099.8	-	1	1290	c.1242G>A	c.(1240-1242)gaG>gaA	p.E414E	ENPP3_ENST00000358229.5_Intron|ENPP3_ENST00000414305.1_Intron|ENPP3_ENST00000357639.3_Intron	NM_001145659.1|NM_001278507.1	NP_001139131.1|NP_001265436.1	A4FU28	CTGE9_HUMAN	CTAGE family, member 9	414						integral to membrane				endometrium(1)|lung(1)	2						TAGAAAGCTTCTCTTCTTCCT	0.368000													20	24					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155264089	155264089	+	Silent	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:155264089C>A	ENST00000392414.3	-	7	1073	c.960G>T	c.(958-960)ctG>ctT	p.L320L	PKLR_ENST00000342741.4_Silent_p.L351L	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	351			V -> L (in PKRD).		endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	TCTTCTGAGCCAGGAAAACCT	0.582000													9	19					5.4927e-09	5.74597e-09	1	1	0
HMHA1	23526	broad.mit.edu	37	19	1085894	1085894	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:1085894C>G	ENST00000313093.2	+	23	3531	c.3300C>G	c.(3298-3300)ttC>ttG	p.F1100L	HMHA1_ENST00000543365.1_Missense_Mutation_p.F983L|HMHA1_ENST00000536472.1_Missense_Mutation_p.F968L|HMHA1_ENST00000590214.1_Missense_Mutation_p.F1127L|HMHA1_ENST00000586866.1_Missense_Mutation_p.F1104L|HMHA1_ENST00000591169.1_3'UTR|HMHA1_ENST00000590577.1_Missense_Mutation_p.F735L|HMHA1_ENST00000539243.2_Missense_Mutation_p.F1116L	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	1100					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTCAGGATTCAACACCAACC	0.692000													30	36					0	0	1	0	0
CEP85	64793	broad.mit.edu	37	1	26584703	26584703	+	Silent	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:26584703C>G	ENST00000252992.4	+	6	1238	c.1107C>G	c.(1105-1107)ctC>ctG	p.L369L	CEP85_ENST00000451429.2_Silent_p.L318L	NM_001281517.1|NM_022778.2	NP_001268446.1|NP_073615.2	Q6P2H3	CEP85_HUMAN	centrosomal protein 85kDa	369						centrosome|nucleolus|spindle pole				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(11)|skin(2)	25						ACAGTGCCCTCTTGGGCCGCC	0.547000													23	66					0	0	1	0	0
ZNF33A	7581	broad.mit.edu	37	10	38345330	38345330	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:38345330C>G	ENST00000374618.3	+	5	2456	c.2278C>G	c.(2278-2280)Caa>Gaa	p.Q760E	ZNF33A_ENST00000458705.2_Missense_Mutation_p.Q759E|ZNF33A_ENST00000432900.2_Missense_Mutation_p.Q766E|ZNF33A_ENST00000307441.9_Missense_Mutation_p.Q759E|ZNF33A_ENST00000469037.2_Intron	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	759						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						AACTTTCTCTCAAAAGTCAAA	0.368000													24	22					0	0	1	0	0
RAB3B	5865	broad.mit.edu	37	1	52385675	52385675	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:52385675G>A	ENST00000371655.3	-	5	796	c.584C>T	c.(583-585)cCg>cTg	p.P195L		NM_002867.3	NP_002858.2	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	195					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	9						CAGCATCGACGGGTCTGTGTC	0.572000													16	26					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116381038	116381038	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:116381038G>A	ENST00000397752.3	+	5	1860	c.1660G>A	c.(1660-1662)Ggg>Agg	p.G554R	MET_ENST00000318493.6_Missense_Mutation_p.G554R|MET_ENST00000495962.1_3'UTR|MET_ENST00000436117.2_Missense_Mutation_p.G554R	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	554					axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			ATGCCTGAGCGGGACATGGAC	0.473000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				40	48					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17758269	17758269	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:17758269C>T	ENST00000428389.2	-	18	2112	c.2113G>A	c.(2113-2115)Gag>Aag	p.E705K	UNC13A_ENST00000550896.1_Missense_Mutation_p.E615K|UNC13A_ENST00000519716.2_Missense_Mutation_p.E617K|UNC13A_ENST00000551649.1_Missense_Mutation_p.E617K|UNC13A_ENST00000252773.7_Missense_Mutation_p.E617K|UNC13A_ENST00000552293.1_Missense_Mutation_p.E617K			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	617	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						GTCCGGTCCTCCGCCCCGTGC	0.647000													21	41					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104174909	104174909	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:104174909G>A	ENST00000020673.5	-	4	1361	c.835C>T	c.(835-837)Cga>Tga	p.R279*	PSD_ENST00000406432.1_Nonsense_Mutation_p.R279*	NM_001270966.1|NM_002779.4	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	279					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		TTGGCTGCTCGCCCCACAGCC	0.657000													14	21					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11565098	11565098	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:11565098C>T	ENST00000304623.8	-	3	434	c.245G>A	c.(244-246)cGa>cAa	p.R82Q	CTNND2_ENST00000511377.1_5'UTR|CTNND2_ENST00000458100.2_5'UTR|CTNND2_ENST00000359640.2_Missense_Mutation_p.R82Q|CTNND2_ENST00000503622.1_5'UTR	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	82					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GAGCTTGCATCGCTCCAGCTG	0.522000													8	30					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42356669	42356669	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:42356669G>C	ENST00000554171.1	+	5	3273	c.841G>C	c.(841-843)Gag>Cag	p.E281Q	LRFN5_ENST00000298119.4_Missense_Mutation_p.E281Q|LRFN5_ENST00000554120.1_Missense_Mutation_p.E281Q			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	281	LRRCT.					integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TCCTGAAGAAGAGTTTTTGTG	0.493000										HNSCC(30;0.082)			21	48					0	0	1	0	0
CCT6P1	643253	broad.mit.edu	37	7	65227987	65227987	+	RNA	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:65227987G>C	ENST00000442266.1	+	0	1221																											ATTGTGTAAAGAAACAGCTTC	0.368000													8	22					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97887869	97887869	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:97887869C>G	ENST00000356526.2	+	1	326	c.326C>G	c.(325-327)aCc>aGc	p.T109S		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						ATTGGCGTAACCACAGAATGT	0.388000													13	288					0	0	1	0	0
AGAP3	116988	broad.mit.edu	37	7	150815385	150815385	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:150815385G>C	ENST00000397238.2	+	6	795	c.795G>C	c.(793-795)gaG>gaC	p.E265D	AGAP3_ENST00000473312.1_Missense_Mutation_p.E265D|AGAP3_ENST00000335367.3_Missense_Mutation_p.E445D|AGAP3_ENST00000479901.1_Missense_Mutation_p.E265D|AGAP3_ENST00000463381.1_Missense_Mutation_p.E37D|AGAP3_ENST00000476375.1_3'UTR	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	229	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						CCTACTATGAGACGTGCGCGA	0.632000													43	44					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14877913	14877913	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:14877913C>T	ENST00000315576.3	-	6	815	c.364G>A	c.(364-366)Gaa>Aaa	p.E122K	EMR2_ENST00000392967.2_Missense_Mutation_p.E122K|EMR2_ENST00000594294.1_Missense_Mutation_p.E122K|EMR2_ENST00000601345.1_Missense_Mutation_p.E122K|EMR2_ENST00000392965.3_Missense_Mutation_p.E122K|EMR2_ENST00000594076.1_Intron|EMR2_ENST00000353876.1_Intron|EMR2_ENST00000595839.1_Intron|EMR2_ENST00000346057.1_Missense_Mutation_p.E122K|EMR2_ENST00000596991.2_Missense_Mutation_p.E122K|EMR2_ENST00000353005.1_Intron|EMR2_ENST00000392964.3_5'UTR	NM_013447.3	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	122	EGF-like 3; calcium-binding.				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						TGCTGACATTCGTCCACATCT	0.577000													41	37					0	0	1	0	0
FAM219A	203259	broad.mit.edu	37	9	34402806	34402806	+	Splice_Site	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr9:34402806C>G	ENST00000445726.1	-	3	467		c.e3-1		FAM219A_ENST00000297620.4_Splice_Site|FAM219A_ENST00000379084.1_Splice_Site|FAM219A_ENST00000379078.1_Splice_Site|FAM219A_ENST00000379081.1_Splice_Site|FAM219A_ENST00000379087.1_Splice_Site|FAM219A_ENST00000379089.1_Splice_Site|FAM219A_ENST00000379080.1_Splice_Site	NM_001184940.1|NM_001184941.1	NP_001171869.1|NP_001171870.1	Q8IW50	CI025_HUMAN	family with sequence similarity 219, member A																		CGCTGCTTCTCTGCAGGAGAA	0.597000													18	7					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669122	234669122	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:234669122C>T	ENST00000360418.3	+	1	189	c.189C>T	c.(187-189)gaC>gaT	p.D63D	UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A1_ENST00000609767.1_Intron|UGT1A3_ENST00000482026.1_Intron|UGT1A8_ENST00000305208.5_Silent_p.D63D|UGT1A1_ENST00000608381.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A1_ENST00000373450.4_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A1_ENST00000609637.1_Intron|UGT1A1_ENST00000608383.1_Silent_p.D63D			P22309	UD11_HUMAN		63					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	TAGCACCTGACGCCTCGTTGT	0.527000													63	33					0	0	1	0	0
MBL2	4153	broad.mit.edu	37	10	54527898	54527898	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:54527898C>T	ENST00000373968.3	-	4	810	c.746G>A	c.(745-747)tGa>tAa	p.*249*		NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	0					acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						TATGACCCTTCAGATAGGGAA	0.463000													46	84					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377272	113377272	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:113377272G>A	ENST00000316407.4	-	7	3667	c.3257C>T	c.(3256-3258)tCt>tTt	p.S1086F	KIAA2018_ENST00000478658.1_Missense_Mutation_p.S1086F|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1086					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TGACATGGGAGAGTCGGCCTG	0.453000													89	47					0	0	1	0	0
CTBP2	1488	broad.mit.edu	37	10	126682440	126682440	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:126682440C>G	ENST00000309035.6	-	6	2645	c.2515G>C	c.(2515-2517)Gag>Cag	p.E839Q	CTBP2_ENST00000337195.5_Missense_Mutation_p.E299Q|CTBP2_ENST00000334808.6_Missense_Mutation_p.E367Q|CTBP2_ENST00000411419.2_Missense_Mutation_p.E299Q|CTBP2_ENST00000531469.1_Missense_Mutation_p.E299Q|CTBP2_ENST00000494626.2_Missense_Mutation_p.E299Q	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	299					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		GGCTCTGACTCATGCACGTCG	0.632000													52	50					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95719701	95719701	+	RNA	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:95719701C>T	ENST00000480546.1	-	0	1596					NR_002319.2																						AAAGTCTCTTCAACTAGAGGT	0.498000													21	29					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145758606	145758606	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:145758606C>G	ENST00000276826.5	-	7	2900	c.2699G>C	c.(2698-2700)aGa>aCa	p.R900T	ARHGAP39_ENST00000540274.1_Missense_Mutation_p.R900T|ARHGAP39_ENST00000377307.2_Missense_Mutation_p.R931T			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	900	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						GTAGCGCTCTCTCTGCATGCC	0.637000													15	96					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43916112	43916112	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:43916112C>T	ENST00000562955.1	+	71	10089	c.10089C>T	c.(10087-10089)atC>atT	p.I3363I	SZT2_ENST00000372442.1_Silent_p.I2521I	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	3420						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						AGTCTGTCATCAACACAGCCT	0.582000													56	35					0	0	1	0	0
MALT1	10892	broad.mit.edu	37	18	56377297	56377297	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr18:56377297C>T	ENST00000348428.3	+	6	1176	c.918C>T	c.(916-918)atC>atT	p.I306I	RP11-126O1.4_ENST00000588835.1_RNA|MALT1_ENST00000345724.3_Silent_p.I306I	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	306					activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						AGGTAGAAATCATCATAGGTA	0.343000			T	BIRC3	MALT								5	99					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179403718	179403718	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:179403718C>A	ENST00000589042.1	-	353	99168	c.98944G>T	c.(98944-98946)Gag>Tag	p.E32982*	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.E30414*|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000359218.5_Nonsense_Mutation_p.E24042*|TTN_ENST00000460472.2_Nonsense_Mutation_p.E23917*|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.E24109*|TTN_ENST00000591111.1_Nonsense_Mutation_p.E31341*|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31341							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGCTGGTCTCACTCAGGCCA	0.463000													16	36					2.23348e-06	2.29676e-06	1	1	0
EP300	2033	broad.mit.edu	37	22	41566488	41566488	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr22:41566488G>A	ENST00000263253.7	+	27	5584	c.4365G>A	c.(4363-4365)caG>caA	p.Q1455Q	RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1455					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						CTCCTGACCAGAAGATACCCA	0.443000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				46	38					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109845639	109845639	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:109845639G>C	ENST00000310903.5	+	10	1134	c.1028G>C	c.(1027-1029)aGa>aCa	p.R343T	MYO1H_ENST00000542883.1_3'UTR|MYO1H_ENST00000431443.2_Missense_Mutation_p.R343T			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						GTCTACGCTAGAGATGCAATG	0.433000													11	43					0	0	1	0	0
HTATSF1	27336	broad.mit.edu	37	X	135591295	135591295	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chrX:135591295G>C	ENST00000535601.1	+	8	1302	c.880G>C	c.(880-882)Gag>Cag	p.E294Q	HTATSF1_ENST00000218364.4_Missense_Mutation_p.E294Q	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	294	RRM 2.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					CCTTCGAGTAGAGTGTTCGAA	0.378000													115	42					0	0	1	0	0
PCIF1	63935	broad.mit.edu	37	20	44569491	44569491	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr20:44569491C>T	ENST00000372409.3	+	6	795	c.431C>T	c.(430-432)tCc>tTc	p.S144F		NM_022104.3	NP_071387.1	Q9H4Z3	PCIF1_HUMAN	PDX1 C-terminal inhibiting factor 1	144						nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	20						GTGCCCAGCTCCCCCAGTATC	0.557000													26	76					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152323362	152323362	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:152323362C>G	ENST00000388718.5	-	3	6972	c.6900G>C	c.(6898-6900)caG>caC	p.Q2300H	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2300							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TATCTCCTGTCTGTCCATGAG	0.473000													47	131					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169391207	169391207	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:169391207G>C	ENST00000545005.1	-	4	969	c.462C>G	c.(460-462)ttC>ttG	p.F154L	CCDC181_ENST00000367806.3_Missense_Mutation_p.F154L|CCDC181_ENST00000367805.3_Missense_Mutation_p.F154L|CCDC181_ENST00000491570.1_5'UTR					coiled-coil domain containing 181																		ACTGGTCCTTGAACTTAAGTT	0.348000													27	62					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241468619	241468619	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:241468619G>A	ENST00000391987.1	-	5	887	c.521C>T	c.(520-522)tCg>tTg	p.S174L	ANKMY1_ENST00000403283.1_Intron|ANKMY1_ENST00000405002.1_Intron|ANKMY1_ENST00000361678.4_Intron|ANKMY1_ENST00000462004.1_Intron|ANKMY1_ENST00000536462.1_Intron|ANKMY1_ENST00000272972.3_Missense_Mutation_p.S174L|ANKMY1_ENST00000401804.1_Missense_Mutation_p.S263L|ANKMY1_ENST00000405523.3_Intron|ANKMY1_ENST00000373320.4_Intron|ANKMY1_ENST00000373318.2_Intron|ANKMY1_ENST00000406958.1_Intron	NM_001282771.1	NP_001269700.1	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	174							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		ACTGTTGGTCGAGTAGACATA	0.502000													20	42					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90086839	90086839	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:90086839G>A	ENST00000405460.2	+	70	14289	c.14193G>A	c.(14191-14193)gtG>gtA	p.V4731V	GPR98_ENST00000425867.2_Silent_p.V392V	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4731	Calx-beta 32.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAGATTATGTGATCCAGCTTG	0.443000													19	29					0	0	1	0	0
GABBR2	9568	broad.mit.edu	37	9	101216318	101216318	+	Missense_Mutation	SNP	G	G	A	rs76761930		TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr9:101216318G>A	ENST00000259455.2	-	7	1640	c.1181C>T	c.(1180-1182)aCg>aTg	p.T394M		NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	394					negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity		NOTCH1_ENST00000277541/GABBR2(2)	breast(4)|endometrium(4)|large_intestine(12)|lung(21)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	49		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	CCTGCCCAGCGTGTGGTCCGT	0.572000													18	20					0	0	1	0	0
CALD1	800	broad.mit.edu	37	7	134618346	134618346	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:134618346G>A	ENST00000361675.2	+	5	1055	c.826G>A	c.(826-828)Gaa>Aaa	p.E276K	CALD1_ENST00000422748.1_Intron|CALD1_ENST00000543443.1_Intron|CALD1_ENST00000393118.2_Intron|CALD1_ENST00000361388.2_Intron|CALD1_ENST00000424922.1_Intron|CALD1_ENST00000417172.1_Intron|CALD1_ENST00000361901.2_Intron|CALD1_ENST00000495522.1_Intron			Q05682	CALD1_HUMAN	caldesmon 1	276					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						GGAAGCAGAAGAAAGAGAAAG	0.443000													8	19					0	0	1	0	0
AADAT	51166	broad.mit.edu	37	4	170988503	170988503	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr4:170988503C>T	ENST00000337664.4	-	9	1213	c.937G>A	c.(937-939)Gaa>Aaa	p.E313K	AADAT_ENST00000353187.2_Missense_Mutation_p.E313K|AADAT_ENST00000515480.1_Missense_Mutation_p.E313K|AADAT_ENST00000509167.1_Missense_Mutation_p.E317K	NM_016228.3	NP_057312.1	Q8N5Z0	AADAT_HUMAN	aminoadipate aminotransferase	313					2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|pancreas(1)|stomach(1)	11		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ATGAAACCTTCTTCTCCCCAT	0.348000													3	33					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49686348	49686348	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:49686348C>T	ENST00000252826.5	+	12	1748	c.1622C>T	c.(1621-1623)tCg>tTg	p.S541L	TRPM4_ENST00000355712.5_Missense_Mutation_p.S187L|TRPM4_ENST00000427978.2_Missense_Mutation_p.S541L	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	541					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TATCTGCTCTCGGACAAGGCC	0.647000													13	14					0	0	1	0	0
NOL8	55035	broad.mit.edu	37	9	95078188	95078188	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr9:95078188C>T	ENST00000545558.1	-	7	1211	c.719G>A	c.(718-720)aGg>aAg	p.R240K	NOL8_ENST00000442668.2_Missense_Mutation_p.R240K|NOL8_ENST00000358855.4_Missense_Mutation_p.R172K|NOL8_ENST00000535387.1_Missense_Mutation_p.R240K|NOL8_ENST00000542053.1_Missense_Mutation_p.R172K			Q76FK4	NOL8_HUMAN	nucleolar protein 8	240					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						TATTACCCTCCTGGGCCTTGT	0.463000													22	45					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51875187	51875187	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:51875187C>T	ENST00000371117.3	-	35	5946	c.5671G>A	c.(5671-5673)Gag>Aag	p.E1891K	PKHD1_ENST00000340994.4_Missense_Mutation_p.E1891K	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1891					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CACTCCATCTCTGCCTCAGTT	0.438000													31	45					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78362990	78362990	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:78362990G>A	ENST00000582970.1	+	65	15161	c.15018G>A	c.(15016-15018)tcG>tcA	p.S5006S	RNF213_ENST00000508628.2_Silent_p.S5055S|CTD-2047H16.4_ENST00000575034.1_RNA|RNF213_ENST00000427003.3_3'UTR|RNF213_ENST00000336301.6_Silent_p.S3079S|CTD-2047H16.4_ENST00000573394.1_RNA|CTD-2047H16.4_ENST00000572151.1_RNA	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TCCCCAGCTCGGTCATTAGTG	0.567000													34	177					0	0	1	0	0
RCC1	1104	broad.mit.edu	37	1	28857058	28857058	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:28857058C>T	ENST00000373831.3	+	3	158	c.97C>T	c.(97-99)Cgc>Tgc	p.R33C	RCC1_ENST00000373832.1_Intron|RCC1_ENST00000373833.6_Intron|RCC1_ENST00000398958.2_Intron	NM_001048194.2|NM_001048195.2	NP_001041659.1|NP_001041660.1	P18754	RCC1_HUMAN	regulator of chromosome condensation 1	24					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		TGCCTCCCGCCGCGTTCCTGG	0.677000													4	9					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10466446	10466446	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:10466446C>A	ENST00000382483.3	-	4	5385	c.5162G>T	c.(5161-5163)aGg>aTg	p.R1721M		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1721					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTGGACAGTCCTAGTGCTCGT	0.657000													3	48					0.115264	0.115264	1	1	0
GPC5	2262	broad.mit.edu	37	13	92346023	92346023	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr13:92346023C>G	ENST00000377067.3	+	3	1280	c.908C>G	c.(907-909)tCg>tGg	p.S303W		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	303						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding	p.S303L(1)		NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GAAGAACTCTCGGATGCAATG	0.488000													20	60					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30699835	30699835	+	Missense_Mutation	SNP	C	C	T	rs142875385		TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:30699835C>T	ENST00000256246.2	-	1	6773	c.6699G>A	c.(6697-6699)atG>atA	p.M2233I		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2233										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CAATCGTTTTCATGACTTTCC	0.338000													25	44					0	0	1	0	0
ACTG1	71	broad.mit.edu	37	17	79478230	79478230	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:79478230G>T	ENST00000575842.1	-	3	1212	c.786C>A	c.(784-786)ttC>ttA	p.F262L	ACTG1_ENST00000331925.2_Missense_Mutation_p.F262L|ACTG1_ENST00000573283.1_Missense_Mutation_p.F262L|ACTG1_ENST00000575087.1_Missense_Mutation_p.F262L			P63261	ACTG_HUMAN	actin, gamma 1	262					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|lung(8)|ovary(2)|prostate(5)|urinary_tract(1)	29	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			AGGAAGGCTGGAACAGCGCCT	0.572000													19	86					7.45023e-12	7.90769e-12	1	1	0
ACAD10	80724	broad.mit.edu	37	12	112147435	112147435	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr12:112147435G>A	ENST00000455480.2	+	5	814	c.637G>A	c.(637-639)Gac>Aac	p.D213N	ACAD10_ENST00000313698.4_Missense_Mutation_p.D213N|ACAD10_ENST00000549590.1_Missense_Mutation_p.D213N|ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000392636.2_5'UTR	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	213							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						CTTTCTTGATGACCTTGGAAC	0.483000													19	44					0	0	1	0	0
LCE1E	353135	broad.mit.edu	37	1	152760055	152760055	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:152760055G>A	ENST00000368770.3	+	2	333	c.280G>A	c.(280-282)Gac>Aac	p.D94N	LCE1E_ENST00000368771.1_Missense_Mutation_p.D94N	NM_178353.1	NP_848130.1	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	94	Cys-rich.				keratinization					lung(5)|stomach(1)	6	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGAGCTCTGACTGCTGCAG	0.672000													47	17					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183643381	183643381	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:183643381G>A	ENST00000334444.6	-	29	4414	c.4174C>T	c.(4174-4176)Cta>Tta	p.L1392L	ABCC5_ENST00000265586.6_Silent_p.L1349L	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	1392	ABC transporter 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCGGAGCCTAGAACCGTGTGC	0.547000													24	38					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138550950	138550950	+	Silent	SNP	A	A	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:138550950A>T	ENST00000251691.4	+	5	547	c.381A>T	c.(379-381)acA>acT	p.T127T		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	127					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ACACGCCAACATTTGATCTGA	0.443000													12	17					0	0	1	0	0
WDR25	79446	broad.mit.edu	37	14	100995525	100995525	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:100995525C>T	ENST00000335290.6	+	6	1619	c.1393C>T	c.(1393-1395)Cgg>Tgg	p.R465W	WDR25_ENST00000557502.1_3'UTR|WDR25_ENST00000402312.3_Missense_Mutation_p.R465W|WDR25_ENST00000542471.2_Missense_Mutation_p.R208W|WDR25_ENST00000554998.1_Missense_Mutation_p.R465W	NM_024515.4	NP_078791.3	Q64LD2	WDR25_HUMAN	WD repeat domain 25	465										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|skin(1)	20		Melanoma(154;0.212)				GAGCAGACGGCGGCGCTATGA	0.637000													10	26					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47497107	47497107	+	Splice_Site	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:47497107G>T	ENST00000371901.3	+	3	569		c.e3-1		CYP4X1_ENST00000538609.1_Splice_Site	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1							endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						TGACTCTGCAGATCCCAAGTC	0.438000													42	124					1.61863e-15	1.73835e-15	1	1	0
ZMIZ1	57178	broad.mit.edu	37	10	81063801	81063801	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr10:81063801T>G	ENST00000334512.5	+	19	2727	c.2155T>G	c.(2155-2157)Tcc>Gcc	p.S719A		NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	719					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CGTGGCTGCCTCCTCGGGCAA	0.632000													5	12					0	0	1	0	0
RTTN	25914	broad.mit.edu	37	18	67718734	67718734	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr18:67718734G>C	ENST00000255674.6	-	39	5522	c.5236C>G	c.(5236-5238)Ctt>Gtt	p.L1746V	RTTN_ENST00000454359.1_3'UTR	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	1746							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				ATGGCCAGAAGATTAAATAAA	0.403000													13	38					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28460878	28460878	+	Missense_Mutation	SNP	G	G	C	rs151115059		TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:28460878G>C	ENST00000261609.7	-	39	6207	c.6099C>G	c.(6097-6099)atC>atG	p.I2033M		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	2033					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCGTGAGAGCGATGCTCCGCA	0.617000													7	20					0	0	1	0	0
POLR3C	10623	broad.mit.edu	37	1	145608482	145608482	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:145608482C>T	ENST00000334163.3	-	3	485	c.325G>A	c.(325-327)Gag>Aag	p.E109K	POLR3C_ENST00000369294.1_Missense_Mutation_p.E109K|POLR3C_ENST00000471254.1_5'UTR	NM_006468.6	NP_006459.3	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide C (62kD)	109					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			AACAGAAGCTCCTCAACAATC	0.493000													45	32					0	0	1	0	0
TRIP4	9325	broad.mit.edu	37	15	64706346	64706346	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:64706346A>T	ENST00000261884.3	+	8	1166	c.1106A>T	c.(1105-1107)gAt>gTt	p.D369V		NM_016213.4	NP_057297.2	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	369					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21						ACCAAATTGGATAGATCTTCT	0.428000													24	12					0	0	1	0	0
CENPU	79682	broad.mit.edu	37	4	185650190	185650190	+	Splice_Site	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr4:185650190C>T	ENST00000281453.5	-	3	167		c.e3-1		MLF1IP_ENST00000541971.1_Splice_Site	NM_024629.3	NP_078905.2	Q71F23	CENPU_HUMAN							CenH3-containing nucleosome assembly at centromere|interspecies interaction between organisms|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|condensed chromosome kinetochore|cytosol|nucleoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|stomach(1)	13		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Hepatocellular(41;0.000519)|Colorectal(36;0.00172)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.0299)|all_hematologic(60;0.0592)|Medulloblastoma(177;0.146)		all cancers(43;7.83e-28)|Epithelial(43;2.56e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-11)|Colorectal(24;3.27e-06)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.16e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000252)|COAD - Colon adenocarcinoma(29;0.000512)|LUSC - Lung squamous cell carcinoma(40;0.01)|READ - Rectum adenocarcinoma(43;0.0419)		GACCAGCTTTCTAAAAGTGAA	0.388000													3	23					0	0	1	0	0
ZNF708	7562	broad.mit.edu	37	19	21477264	21477264	+	Silent	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:21477264G>A	ENST00000356929.3	-	4	701	c.504C>T	c.(502-504)ttC>ttT	p.F168F		NM_021269.2	NP_067092.2	P17019	ZN708_HUMAN	zinc finger protein 708	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F168L(1)		breast(1)|central_nervous_system(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(2)|stomach(1)	32						CTTTACATTTGAAAGGATTTT	0.328000													12	40					0	0	1	0	0
RAB12	201475	broad.mit.edu	37	18	8633290	8633290	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr18:8633290G>C	ENST00000329286.6	+	3	674	c.391G>C	c.(391-393)Gat>Cat	p.D131H		NM_001025300.2	NP_001020471.2	Q6IQ22	RAB12_HUMAN	RAB12, member RAS oncogene family	131					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			breast(1)|lung(4)|prostate(1)|urinary_tract(1)	7						GGAGACATTTGATGATTTGCC	0.368000													6	122					0	0	1	0	0
ABHD2	11057	broad.mit.edu	37	15	89695026	89695026	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:89695026G>C	ENST00000352732.5	+	4	833	c.313G>C	c.(313-315)Gat>Cat	p.D105H	ABHD2_ENST00000355100.3_Missense_Mutation_p.D105H|ABHD2_ENST00000565973.1_Missense_Mutation_p.D105H	NM_152924.4	NP_690888.1	P08910	ABHD2_HUMAN	abhydrolase domain containing 2	105						integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|soft_tissue(1)	23	Lung NSC(78;0.0472)|all_lung(78;0.089)					CACTATGTCTGATGGAGCCAC	0.517000													78	31					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4674658	4674658	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:4674658T>A	ENST00000396952.5	+	2	1552	c.902T>A	c.(901-903)aTt>aAt	p.I301N	OR51E1_ENST00000530215.1_3'UTR	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACAAAGGAGATTCGACAGCGC	0.502000													32	63					0	0	1	0	0
NMT1	4836	broad.mit.edu	37	17	43138713	43138713	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:43138713G>C	ENST00000592782.1	+	2	147	c.16G>C	c.(16-18)Gag>Cag	p.E6Q	NMT1_ENST00000590114.1_3'UTR|NMT1_ENST00000258960.2_Missense_Mutation_p.E6Q			P30419	NMT1_HUMAN	N-myristoyltransferase 1	6					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	8		Prostate(33;0.155)				GGACGAGAGTGAGACAGCAGT	0.597000													3	15					0	0	1	0	0
CELF1	10658	broad.mit.edu	37	11	47510469	47510469	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:47510469C>T	ENST00000395290.2	-	1	107	c.98G>A	c.(97-99)cGg>cAg	p.R33Q	CELF1_ENST00000310513.5_Missense_Mutation_p.R33Q|CELF1_ENST00000395292.2_Missense_Mutation_p.R33Q|CELF1_ENST00000361904.3_Missense_Mutation_p.R33Q|CELF1_ENST00000532048.1_Missense_Mutation_p.R60Q|CELF1_ENST00000531165.1_Missense_Mutation_p.R60Q|CELF1_ENST00000358597.3_Missense_Mutation_p.R33Q	NM_001025596.2|NM_001172640.1	NP_001020767.1|NP_001166111.1	Q92879	CELF1_HUMAN	CUGBP, Elav-like family member 1	33	RRM 1.				embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding	p.R33L(1)		central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)	18						GAAGAGTTCCCGCAAGTCCTT	0.502000													40	59					0	0	1	0	0
SLC19A3	80704	broad.mit.edu	37	2	228563522	228563522	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr2:228563522C>A	ENST00000258403.3	-	3	980	c.909G>T	c.(907-909)tgG>tgT	p.W303C	SLC19A3_ENST00000541617.1_Missense_Mutation_p.W299C|SLC19A3_ENST00000409287.1_Intron	NM_025243.3	NP_079519.1	Q9BZV2	S19A3_HUMAN	solute carrier family 19 (thiamine transporter), member 3	303					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|skin(3)	30		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	CCTTGTAATCCCACAGGATTT	0.443000													18	65					1.99824e-07	2.06655e-07	1	1	0
CDK5RAP1	51654	broad.mit.edu	37	20	31961946	31961946	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr20:31961946G>A	ENST00000357886.4	-	10	1375	c.1222C>T	c.(1222-1224)Cgt>Tgt	p.R408C	CDK5RAP1_ENST00000544843.1_Missense_Mutation_p.R394C|CDK5RAP1_ENST00000477105.1_5'UTR|CDK5RAP1_ENST00000346416.2_Missense_Mutation_p.R394C|CDK5RAP1_ENST00000339269.5_Missense_Mutation_p.R317C|CDK5RAP1_ENST00000473997.1_Missense_Mutation_p.R304C			Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	408					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(12)|ovary(3)|skin(3)|urinary_tract(1)	26						TCCAACACACGGCTGCTTCCA	0.502000													5	126					0	0	1	0	0
C19orf40	91442	broad.mit.edu	37	19	33467501	33467501	+	Silent	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr19:33467501G>C	ENST00000588258.1	+	5	671	c.561G>C	c.(559-561)ctG>ctC	p.L187L	C19orf40_ENST00000589646.1_Silent_p.L92L|C19orf40_ENST00000590281.1_Silent_p.L187L|C19orf40_ENST00000590179.1_Silent_p.L92L	NM_152266.3	NP_689479.1	Q9BTP7	FAP24_HUMAN	chromosome 19 open reading frame 40	187	RuvA domain 2-like.				DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7	Esophageal squamous(110;0.137)					TCCAGCAACTGAGTAATGCTT	0.557000								Direct reversal of damage			OREG0025408	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	93					0	0	1	0	0
FDXACB1	91893	broad.mit.edu	37	11	111746622	111746622	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr11:111746622G>A	ENST00000260257.4	-	5	946	c.899C>T	c.(898-900)tCt>tTt	p.S300F	ALG9_ENST00000527377.1_5'UTR|FDXACB1_ENST00000542429.1_Missense_Mutation_p.S151F|ALG9_ENST00000524880.1_Intron	NM_138378.2	NP_612387.1	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain containing 1	300					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(3)	19						CAGGGACTCAGAATTTGAGTT	0.428000													10	21					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235973465	235973465	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:235973465G>T	ENST00000389794.3	-	5	827	c.653C>A	c.(652-654)gCt>gAt	p.A218D	LYST_ENST00000389793.2_Missense_Mutation_p.A218D|LYST_ENST00000536965.1_Missense_Mutation_p.A218D			Q99698	LYST_HUMAN	lysosomal trafficking regulator	218					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CAAAGCCATAGCATCTGGAGG	0.433000													41	101					2.47872e-24	2.7266e-24	1	1	0
SEL1L	6400	broad.mit.edu	37	14	81943501	81943501	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr14:81943501C>T	ENST00000336735.4	-	21	2316	c.2200G>A	c.(2200-2202)Gat>Aat	p.D734N		NM_005065.5	NP_005056.3	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like (C. elegans)	734	Interaction with ERLEC1, OS9 and SYVN1.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	28				BRCA - Breast invasive adenocarcinoma(234;0.0299)		TGGTCCATATCAAGTTGGGTG	0.423000													7	25					0	0	1	0	0
RPL24	6152	broad.mit.edu	37	3	101404752	101404752	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:101404752C>T	ENST00000469605.1	-	3	120	c.102G>A	c.(100-102)gcG>gcA	p.A34A	RPL24_ENST00000394077.3_Silent_p.A34A|RPL24_ENST00000495401.1_Silent_p.A34A			P83731	RL24_HUMAN	ribosomal protein L24	34					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			large_intestine(1)|lung(2)|urinary_tract(1)	4						ACTCGCATTTCGCATTAAGAA	0.418000													34	86					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91694573	91694573	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr7:91694573G>C	ENST00000359028.2	+	26	6267	c.6042G>C	c.(6040-6042)atG>atC	p.M2014I	AKAP9_ENST00000356239.3_Missense_Mutation_p.M2002I|AKAP9_ENST00000491695.1_3'UTR|AKAP9_ENST00000358100.2_Missense_Mutation_p.M2014I			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2014	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAAATTAATGAAGGAAAAAC	0.294000			T	BRAF	papillary thyroid								22	33					0	0	1	0	0
MUC21	394263	broad.mit.edu	37	6	30955025	30955025	+	Missense_Mutation	SNP	G	G	A	rs55763085		TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:30955025G>A	ENST00000376296.3	+	2	1314	c.1073G>A	c.(1072-1074)aGc>aAc	p.S358N	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	358	28 X 15 AA approximate tandem repeats.|Ser-rich.					integral to membrane|plasma membrane		p.S358N(1)		NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						AGTGGGGCCAGCACAGCCACC	0.642000													4	116					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84700186	84700186	+	Splice_Site	SNP	T	T	G			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:84700186T>G	ENST00000286744.5	+	28	4978		c.e28+2		ADAMTSL3_ENST00000567476.1_Splice_Site	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CAGAAAGAGGTAGGGGCCCCA	0.512000													31	70					0	0	1	0	0
PSIP1	11168	broad.mit.edu	37	9	15486845	15486845	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr9:15486845C>A	ENST00000380733.4	-	5	716	c.373G>T	c.(373-375)Gaa>Taa	p.E125*	PSIP1_ENST00000380738.4_Nonsense_Mutation_p.E125*|PSIP1_ENST00000380716.4_Nonsense_Mutation_p.E125*|PSIP1_ENST00000380715.1_Nonsense_Mutation_p.E125*|PSIP1_ENST00000397519.2_Nonsense_Mutation_p.E125*			O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1	125					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(2)|endometrium(2)|kidney(1)|lung(3)|prostate(1)	9				GBM - Glioblastoma multiforme(50;2.38e-06)		GCTTTTTCTTCATGGTCGGTA	0.348000													19	16					1.01871e-10	1.07186e-10	1	1	0
ZNF608	57507	broad.mit.edu	37	5	123980306	123980306	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr5:123980306G>C	ENST00000306315.5	-	5	4189	c.3754C>G	c.(3754-3756)Ctg>Gtg	p.L1252V	ZNF608_ENST00000504926.1_Missense_Mutation_p.L825V	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1252						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TGCTGATCCAGATATTTGGGC	0.358000													28	25					0	0	1	0	0
PNMT	5409	broad.mit.edu	37	17	37824887	37824887	+	Silent	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:37824887C>T	ENST00000269582.2	+	1	477	c.159C>T	c.(157-159)gtC>gtT	p.V53V	PNMT_ENST00000394246.1_Intron|PNMT_ENST00000581428.1_Silent_p.V53V	NM_002686.3	NP_002677.1	P11086	PNMT_HUMAN	phenylethanolamine N-methyltransferase	53					catecholamine biosynthetic process|hormone biosynthetic process	cytosol	phenylethanolamine N-methyltransferase activity			NS(1)|breast(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CGAACGGCGTCGGGCCGTGGA	0.697000													5	9					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7583745	7583745	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr6:7583745C>T	ENST00000379802.3	+	24	6591	c.6250C>T	c.(6250-6252)Cag>Tag	p.Q2084*	DSP_ENST00000418664.2_Nonsense_Mutation_p.Q1485*	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2084	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CGATGACCGTCAGCAGATATA	0.453000													44	116					0	0	1	0	0
FRG1	2483	broad.mit.edu	37	4	190878611	190878611	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr4:190878611A>C	ENST00000226798.4	+	6	713	c.491A>C	c.(490-492)gAc>gCc	p.D164A	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	164					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		GAAGCAGGGGACATAGAAGCA	0.373000													3	27					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180885514	180885516	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr1:180885514_180885516delAGA	ENST00000367588.4	+	2	330_332	c.275_277delAGA	c.(274-279)gagaag>gag	p.K93del		NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	93										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						GCTTTGAAGGAGAAGATGACAGT	0.591													13	26	---	---	---	---					
GMPS	8833	broad.mit.edu	37	3	155633812	155633812	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr3:155633812delC	ENST00000496455.2	+	9	1378	c.1043delC	c.(1042-1044)gccfs	p.A348fs	GMPS_ENST00000295920.7_Frame_Shift_Del_p.A249fs	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase						glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TTATAGATTGCCAATGAAGTA	0.358			T	MLL	AML								12	16	---	---	---	---					
PRKDC	5591	broad.mit.edu	37	8	48866910	48866910	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr8:48866910delT	ENST00000314191.2	-	5	552	c.496delA	c.(496-498)atafs	p.I166fs	PRKDC_ENST00000338368.3_Frame_Shift_Del_p.I166fs|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	166					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GTATCTGGTATTTTTTTTTTC	0.264								Non-homologous end-joining					2	4	---	---	---	---					
SCAND2P	54581	broad.mit.edu	37	15	85177446	85177456	+	RNA	DEL	CCCCGCGGCGG	CCCCGCGGCGG	-			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:85177446_85177456delCCCCGCGGCGG	ENST00000348993.5	+	0	848					NR_003654.2																						ccgcggccgaccccgcggcggccgcgtcccc	0.687													8	2	---	---	---	---					
WDR73	84942	broad.mit.edu	37	15	85186877	85186894	+	In_Frame_Del	DEL	CTTGGCTCCGTGTTCCAT	CTTGGCTCCGTGTTCCAT	-	rs143462247		TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr15:85186877_85186894delCTTGGCTCCGTGTTCCAT	ENST00000434634.2	-	8	1004_1021	c.944_961delATGGAACACGGAGCCAAG	c.(943-963)gatggaacacggagccaagta>gta	p.DGTRSQ315del	WDR73_ENST00000398528.3_5'UTR	NM_032856.2	NP_116245.2	Q6P4I2	WDR73_HUMAN	WD repeat domain 73	315										cervix(1)|large_intestine(1)|lung(1)	3						AGAGGTTCTACTTGGCTCCGTGTTCCATCTTGGCTCCG	0.509													11	10	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578213	7578213	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr17:7578213delA	ENST00000420246.2	-	6	768	c.636delT	c.(634-636)tttfs	p.F212fs	TP53_ENST00000445888.2_Frame_Shift_Del_p.F212fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.F212fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.F212fs|TP53_ENST00000574684.1_Intron|TP53_ENST00000413465.2_Frame_Shift_Del_p.F212fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.F212fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	212	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		F -> I (in sporadic cancers; somatic mutation).|F -> L (in sporadic cancers; somatic mutation).|F -> S (in sporadic cancers; somatic mutation).|F -> V (in a sporadic cancer; somatic mutation).|F -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.F212fs*3(6)|p.?(5)|p.R213fs*35(3)|p.F212L(2)|p.D208fs*1(1)|p.R209_R213delRNTFR(1)|p.F119fs*3(1)|p.T211fs*28(1)|p.D207_R213delDDRNTFR(1)|p.D207_V216del10(1)|p.T211_S215delTFRHS(1)|p.F80fs*3(1)|p.R120fs*35(1)|p.R209fs*6(1)|p.R81fs*>11(1)|p.D208_V216delDRNTFRHSV(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACTATGTCGAAAAGTGTTTC	0.532		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			39	12	---	---	---	---					
SIRPD	128646	broad.mit.edu	37	20	1532455	1532455	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chr20:1532455delG	ENST00000381623.3	-	2	1492	c.303delC	c.(301-303)tccfs	p.S101fs	SIRPD_ENST00000381621.1_Frame_Shift_Del_p.S101fs			Q9H106	SIRPD_HUMAN	signal-regulatory protein delta	101	Ig-like V-type.					extracellular region				breast(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)	15						GGATGCGGGTGGAAAAGTCTG	0.463													30	83	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44922719	44922726	+	Frame_Shift_Del	DEL	CAACAGCT	CAACAGCT	-			TCGA-DK-AA6W-01A-12D-A391-08	TCGA-DK-AA6W-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	00ad48e9-7f54-48bb-9948-f5b46103575b	b44c761c-c9f6-444e-a490-86e1a901abbd	g.chrX:44922719_44922726delCAACAGCT	ENST00000377967.4	+	16	1621_1628	c.1580_1587delCAACAGCT	c.(1579-1587)ccaacagctfs	p.PTA527fs	KDM6A_ENST00000382899.4_Frame_Shift_Del_p.PTA534fs|KDM6A_ENST00000543216.1_Frame_Shift_Del_p.PTA448fs|KDM6A_ENST00000536777.1_Frame_Shift_Del_p.PTA482fs	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	527					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.0(2)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						CCTAATGGGCCAACAGCTGACTCATCAC	0.500			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								9	8	---	---	---	---					
