Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CRB1	23418	broad.mit.edu	37	1	197313415	197313415	+	Silent	SNP	A	A	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:197313415A>G	ENST00000367400.3	+	3	792	c.657A>G	c.(655-657)gtA>gtG	p.V219V	CRB1_ENST00000543483.1_5'UTR|CRB1_ENST00000535699.1_Silent_p.V150V|CRB1_ENST00000367399.2_Intron|CRB1_ENST00000538660.1_Silent_p.V219V	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	219	EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding	p.V219V(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TAAAAGGTGTAAACTGTGAAT	0.398000													46	130					0	0	1	0	0
ZNF224	7767	broad.mit.edu	37	19	44612405	44612405	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr19:44612405C>T	ENST00000336976.6	+	6	2346	c.2092C>T	c.(2092-2094)Cat>Tat	p.H698Y	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	698					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				CCTTCGACTTCATCAGAATGT	0.418000													18	11					0	0	1	0	0
ODC1	4953	broad.mit.edu	37	2	10581774	10581774	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr2:10581774C>A	ENST00000234111.4	-	11	1612	c.1102G>T	c.(1102-1104)Gag>Tag	p.E368*	ODC1_ENST00000405333.1_Nonsense_Mutation_p.E368*	NM_002539.1	NP_002530.1	P11926	DCOR_HUMAN	ornithine decarboxylase 1	368					polyamine biosynthetic process|regulation of cellular amino acid metabolic process|response to virus	cytosol	ornithine decarboxylase activity|protein binding			NS(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(3)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.161)	Pyridoxal Phosphate(DB00114)|Spermine(DB00127)	TCACAGCGCTCAACAATCCGA	0.473000													30	42					1.99505e-19	2.15557e-19	1	1	0
HECTD1	25831	broad.mit.edu	37	14	31576229	31576229	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr14:31576229C>G	ENST00000399332.1	-	38	7337	c.6849G>C	c.(6847-6849)atG>atC	p.M2283I	HECTD1_ENST00000553700.1_Missense_Mutation_p.M2283I	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	2283	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TCAGTTTACTCATATTGCTTT	0.363000													27	31					0	0	1	0	0
FEM1C	56929	broad.mit.edu	37	5	114860685	114860685	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr5:114860685A>T	ENST00000274457.3	-	3	1735	c.1174T>A	c.(1174-1176)Ttt>Att	p.F392I		NM_020177.2	NP_064562.1	Q96JP0	FEM1C_HUMAN	fem-1 homolog c (C. elegans)	392						cytoplasm				breast(5)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	18		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)		TGTAGCATAAAGGAGAATAGT	0.433000													19	36					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115231273	115231273	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:115231273C>G	ENST00000369538.3	-	2	258	c.211G>C	c.(211-213)Gat>Cat	p.D71H	AMPD1_ENST00000353928.6_Missense_Mutation_p.D42H|AMPD1_ENST00000520113.2_Missense_Mutation_p.D75H	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	42					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TCATCCACATCAAAGGGGGAA	0.453000													15	122					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152534599	152534599	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr2:152534599T>A	ENST00000427231.2	-	33	3560	c.3358A>T	c.(3358-3360)Ata>Tta	p.I1120L	NEB_ENST00000604864.1_Missense_Mutation_p.I1120L|NEB_ENST00000603639.1_Missense_Mutation_p.I1120L|NEB_ENST00000409198.1_Missense_Mutation_p.I1120L|NEB_ENST00000397345.3_Missense_Mutation_p.I1120L|NEB_ENST00000172853.10_Missense_Mutation_p.I1120L	NM_001164507.1|NM_001271208.1	NP_001157979|NP_001258137.1	P20929	NEBU_HUMAN	nebulin	1120					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCTGATTGTATCTTGGCCACG	0.403000													7	15					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81112796	81112796	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr12:81112796C>T	ENST00000228644.3	+	3	886	c.734C>T	c.(733-735)gCt>gTt	p.A245V		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	245					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						ACTCCAGGGGCTTCTAGTTCC	0.502000													9	56					0	0	1	0	0
PPM1J	333926	broad.mit.edu	37	1	113254634	113254634	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:113254634C>G	ENST00000464951.1	-	6	1676	c.268G>C	c.(268-270)Gag>Cag	p.E90Q	PPM1J_ENST00000359994.4_Missense_Mutation_p.E90Q|PPM1J_ENST00000309276.6_Missense_Mutation_p.E296Q			Q5JR12	PPM1J_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1J	296										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	14	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGGTAAACTCCCGGGACATT	0.517000													11	12					0	0	1	0	0
LEPRE1	64175	broad.mit.edu	37	1	43223456	43223456	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:43223456C>A	ENST00000236040.4	-	5	1118	c.1078G>T	c.(1078-1080)Gag>Tag	p.E360*	LEPRE1_ENST00000397054.3_Nonsense_Mutation_p.E360*|LEPRE1_ENST00000296388.5_Nonsense_Mutation_p.E360*	NM_001243246.1	NP_001230175.1	Q32P28	P3H1_HUMAN	leucine proline-enriched proteoglycan (leprecan) 1	360					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			large_intestine(2)|lung(15)|ovary(5)|prostate(1)|urinary_tract(3)	26	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCTCTCACCTCACGGGGGCCG	0.537000											OREG0013423	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	67	75					7.46257e-40	8.15676e-40	1	1	0
LMTK3	114783	broad.mit.edu	37	19	49012112	49012112	+	Missense_Mutation	SNP	A	A	C			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr19:49012112A>C	ENST00000600059.1	-	5	780	c.553T>G	c.(553-555)Tac>Gac	p.Y185D	LMTK3_ENST00000270238.3_Missense_Mutation_p.Y214D					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CAGTACCTGTACGGCTGTGCT	0.582000													5	54					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664141	22664141	+	RNA	SNP	G	G	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr22:22664141G>A	ENST00000426066.1	+	0	664					NR_027293.1																						AAATTTGAAGGTGCTGTGATT	0.448000													3	58					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165523	172165523	+	Nonsense_Mutation	SNP	A	A	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr3:172165523A>T	ENST00000241256.2	-	1	723	c.681T>A	c.(679-681)tgT>tgA	p.C227*	GHSR_ENST00000427970.1_Nonsense_Mutation_p.C227*	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	227					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GGACCGTGAGACAGAAGACAG	0.607000													13	39					0	0	1	0	0
SAFB	6294	broad.mit.edu	37	19	5661536	5661536	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr19:5661536C>T	ENST00000292123.5	+	15	1977	c.1870C>T	c.(1870-1872)Cgt>Tgt	p.R624C	SAFB_ENST00000538656.1_Missense_Mutation_p.R466C|SAFB_ENST00000454510.1_Missense_Mutation_p.R555C|SAFB_ENST00000433404.1_Missense_Mutation_p.R454C|SAFB_ENST00000588852.1_Missense_Mutation_p.R624C|SAFB_ENST00000592224.1_Missense_Mutation_p.R623C	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	624	Arg-rich.|Interaction with POLR2A.|Interaction with SAFB2.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		CAGCAGGGTGCGTGAACGCAG	0.632000													10	26					0	0	1	0	0
ZNF460	10794	broad.mit.edu	37	19	57803580	57803580	+	Silent	SNP	A	A	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr19:57803580A>G	ENST00000360338.3	+	3	1993	c.1671A>G	c.(1669-1671)gaA>gaG	p.E557E	ZNF460_ENST00000537645.1_Silent_p.E516E	NM_006635.3	NP_006626.3	Q14592	ZN460_HUMAN	zinc finger protein 460	557					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCATAGTGGAAGAAACCCTAC	0.413000													11	80					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94693464	94693464	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr4:94693464A>G	ENST00000282020.4	+	16	3097	c.2839A>G	c.(2839-2841)Aaa>Gaa	p.K947E	GRID2_ENST00000510992.1_Missense_Mutation_p.K852E	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	947	Interaction with AP4M1 (By similarity).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ACTGTCAGCTAAAGCTGCTTC	0.483000													14	46					0	0	1	0	0
GLOD5	392465	broad.mit.edu	37	X	48631836	48631836	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chrX:48631836C>A	ENST00000303227.6	+	4	509	c.468C>A	c.(466-468)aaC>aaA	p.N156K	GLOD5_ENST00000470676.1_3'UTR	NM_001080489.2	NP_001073958.2			glyoxalase domain containing 5											endometrium(1)|lung(2)	3						AGGTGTCCAACTACATCTCCT	0.567000													29	51					2.80507e-11	2.96266e-11	1	1	0
PRICKLE1	144165	broad.mit.edu	37	12	42853988	42853988	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr12:42853988C>T	ENST00000455697.1	-	8	2404	c.2119G>A	c.(2119-2121)Gat>Aat	p.D707N	PRICKLE1_ENST00000552240.1_Missense_Mutation_p.D707N|RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.D707N|PRICKLE1_ENST00000445766.2_Missense_Mutation_p.D707N|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.D707N	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	707					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		TCATAGTTATCGGGGGTGTAC	0.498000													35	61					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869998	36869998	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr20:36869998T>A	ENST00000279024.4	-	3	806	c.535A>T	c.(535-537)Acc>Tcc	p.T179S		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	179										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				GTTATCTTGGTCCAAGGCACA	0.532000													16	103					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201984342	201984342	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:201984342A>T	ENST00000359651.3	+	8	4199	c.1007A>T	c.(1006-1008)tAc>tTc	p.Y336F	ELF3_ENST00000367284.5_Missense_Mutation_p.Y336F|RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367283.3_Missense_Mutation_p.Y336F			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	336					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						CCCAGGTACTACTACAAACGG	0.592000													33	33					0	0	1	0	0
SMCO1	255798	broad.mit.edu	37	3	196234787	196234787	+	Missense_Mutation	SNP	C	C	T	rs62410569		TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr3:196234787C>T	ENST00000397537.2	-	3	772	c.616G>A	c.(616-618)Gaa>Aaa	p.E206K		NM_001077657.1	NP_001071125.1			single-pass membrane protein with coiled-coil domains 1																		atcaaCTCTTCGAGGGATGAC	0.443000													7	19					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161578	90161578	+	RNA	SNP	G	G	A	rs13337896	by1000genomes	TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr16:90161578G>A	ENST00000564451.1	+	0	931				TUBB8P7_ENST00000567960.1_RNA														p.R105H(3)									GCCAAGGGACGCTACACCGAA	0.587000													4	48					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887612	12887612	+	Missense_Mutation	SNP	T	T	C	rs60558629		TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:12887612T>C	ENST00000535591.1	-	3	440	c.245A>G	c.(244-246)cAt>cGt	p.H82R		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	82								p.H82R(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GAAGCACCCATGGGCCATAGC	0.488000													5	374					0	0	1	0	0
MAP3K8	1326	broad.mit.edu	37	10	30728018	30728018	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr10:30728018C>T	ENST00000263056.1	+	3	847	c.151C>T	c.(151-153)Caa>Taa	p.Q51*	MAP3K8_ENST00000375321.1_Nonsense_Mutation_p.Q51*|MAP3K8_ENST00000542547.1_Nonsense_Mutation_p.Q51*|MAP3K8_ENST00000375322.2_Nonsense_Mutation_p.Q51*	NM_001244134.1|NM_005204.3	NP_001231063.1|NP_005195.2	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase 8	51					cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Prostate(175;0.151)				GACCATGTGTCAAGACAGTAA	0.388000													10	45					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154194915	154194915	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chrX:154194915G>T	ENST00000360256.4	-	8	1257	c.1057C>A	c.(1057-1059)Caa>Aaa	p.Q353K		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	353					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	ATTCGTAGTTGGGGTTCCTCT	0.413000													18	43					5.03518e-11	5.25897e-11	1	1	0
GPRIN1	114787	broad.mit.edu	37	5	176025449	176025449	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr5:176025449T>A	ENST00000303991.4	-	2	1564	c.1387A>T	c.(1387-1389)Agg>Tgg	p.R463W		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	463						growth cone|plasma membrane				NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGTCCTCCCTTCTGGAGGAC	0.522000													23	41					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	103797741	103797741	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr11:103797741A>G	ENST00000302251.5	-	6	1319	c.868T>C	c.(868-870)Tgc>Cgc	p.C290R	PDGFD_ENST00000393158.2_Missense_Mutation_p.C296R	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	296					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		ACGAGGAGGCAACGTGGAAAG	0.483000													36	6					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31576197	31576197	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr14:31576197C>T	ENST00000399332.1	-	38	7369	c.6881G>A	c.(6880-6882)aGa>aAa	p.R2294K	HECTD1_ENST00000553700.1_Missense_Mutation_p.R2294K	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	2294	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GTGTAAGTCTCTATCACCTCG	0.358000													27	32					0	0	1	0	0
HIPK2	28996	broad.mit.edu	37	7	139305249	139305249	+	Silent	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr7:139305249C>T	ENST00000406875.3	-	7	1774	c.1680G>A	c.(1678-1680)acG>acA	p.T560T	HIPK2_ENST00000428878.2_Silent_p.T560T|HIPK2_ENST00000342645.6_Silent_p.T560T	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	560	Interaction with SKI and SMAD1.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					TCTGGTTCACCGTGTCATACA	0.507000											OREG0018361	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	62	106					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49068425	49068425	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chrX:49068425C>T	ENST00000376265.2	-	35	4127	c.4066G>A	c.(4066-4068)Gat>Aat	p.D1356N	CACNA1F_ENST00000376251.1_Missense_Mutation_p.D1291N|CACNA1F_ENST00000323022.5_Missense_Mutation_p.D1345N	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1356					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	TGTGTGCCATCCTGAAGAGCC	0.517000													37	49					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21268148	21268148	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:21268148G>A	ENST00000602326.1	-	12	1932	c.1349C>T	c.(1348-1350)gCt>gTt	p.A450V	EIF4G3_ENST00000356916.3_Missense_Mutation_p.A455V|EIF4G3_ENST00000374937.3_Missense_Mutation_p.A450V|EIF4G3_ENST00000400422.1_Missense_Mutation_p.A444V|EIF4G3_ENST00000374935.3_Intron|EIF4G3_ENST00000264211.8_Missense_Mutation_p.A444V|EIF4G3_ENST00000536266.1_Missense_Mutation_p.A48V|EIF4G3_ENST00000374927.4_Missense_Mutation_p.A444V	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	444					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TGTGATGGCAGCACTCGGAGA	0.488000													4	151					0	0	1	0	0
RSPRY1	89970	broad.mit.edu	37	16	57241992	57241992	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr16:57241992A>G	ENST00000537866.1	+	3	1246	c.373A>G	c.(373-375)Atg>Gtg	p.M125V	RSPRY1_ENST00000394420.4_Missense_Mutation_p.M125V			Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	125						extracellular region	zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|urinary_tract(3)	27						TCCCTATTCAATGATAACATT	0.299000													72	109					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237540653	237540653	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:237540653C>T	ENST00000366574.2	+	8	811	c.494C>T	c.(493-495)gCc>gTc	p.A165V	RYR2_ENST00000542537.1_Missense_Mutation_p.A149V|RYR2_ENST00000360064.6_Missense_Mutation_p.A163V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	165	MIR 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATACACCCTGCCTCTAAGCAG	0.423000													6	18					0	0	1	0	0
ZC3H18	124245	broad.mit.edu	37	16	88689632	88689632	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr16:88689632C>T	ENST00000301011.5	+	10	1873	c.1673C>T	c.(1672-1674)tCt>tTt	p.S558F	ZC3H18_ENST00000452588.2_Missense_Mutation_p.S582F	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	558	Ser-rich.					nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CCCAGGTCGTCTTCGCGGTCA	0.657000													3	32					0	0	1	0	0
GPR50	9248	broad.mit.edu	37	X	150349435	150349435	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chrX:150349435C>G	ENST00000218316.3	+	2	1449	c.1380C>G	c.(1378-1380)ttC>ttG	p.F460L		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	460	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					CTGTCCATTTCAAGCCTGACT	0.547000													57	226					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													4	32					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766241	77766241	+	Missense_Mutation	SNP	A	A	C			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr8:77766241A>C	ENST00000521891.2	+	10	7532	c.7084A>C	c.(7084-7086)Aag>Cag	p.K2362Q	ZFHX4_ENST00000518282.1_Missense_Mutation_p.K2336Q|ZFHX4_ENST00000050961.6_Missense_Mutation_p.K2317Q|ZFHX4_ENST00000455469.2_Missense_Mutation_p.K2317Q	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2317	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGTGGTATACAAGCATTGCAC	0.502000										HNSCC(33;0.089)			39	171					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140969350	140969350	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chrX:140969350T>C	ENST00000298296.1	+	4	677	c.677T>C	c.(676-678)tTc>tCc	p.F226S	MAGEC3_ENST00000443323.2_Intron|MAGEC3_ENST00000536088.1_Intron|MAGEC3_ENST00000448920.1_Intron	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	226	MAGE 1.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					CCTATGATCTTCAGGAAAGCC	0.433000													69	76					0	0	1	0	0
RNF121	55298	broad.mit.edu	37	11	71698077	71698077	+	Silent	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr11:71698077C>T	ENST00000361756.3	+	5	787	c.426C>T	c.(424-426)atC>atT	p.I142I	RNF121_ENST00000533380.1_Intron|RNF121_ENST00000545854.1_Silent_p.I61I|RNF121_ENST00000530137.1_Silent_p.I110I|RNF121_ENST00000393713.3_Silent_p.I110I|RNF121_ENST00000490867.1_3'UTR	NM_018320.4	NP_060790.2	Q9H920	RN121_HUMAN	ring finger protein 121	142						integral to membrane	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|urinary_tract(1)	13						TCCTGCTAATCTATAAAATCA	0.428000													28	65					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55135821	55135821	+	Silent	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr11:55135821C>T	ENST00000314706.3	+	1	462	c.462C>T	c.(460-462)atC>atT	p.I154I		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						ACATGGCCATCTGTAAGCCTC	0.438000													68	148					0	0	1	0	0
PYCARD	29108	broad.mit.edu	37	16	31213094	31213094	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr16:31213094C>T	ENST00000247470.9	-	3	701	c.400G>A	c.(400-402)Gat>Aat	p.D134N	PYCARD_ENST00000350605.4_Missense_Mutation_p.D115N	NM_013258.4	NP_037390.2	Q9ULZ3	ASC_HUMAN	PYD and CARD domain containing	134	CARD.				induction of apoptosis|positive regulation of interleukin-1 beta secretion|positive regulation of NF-kappaB transcription factor activity|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex	caspase activator activity|cysteine-type endopeptidase activity|protein homodimerization activity|Pyrin domain binding			NS(1)|kidney(1)	2						TACAGAGCATCCAGCAGCCAC	0.602000													36	45					0	0	1	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91526743	91526743	+	Silent	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr14:91526743C>T	ENST00000261991.3	-	1	209	c.36G>A	c.(34-36)gcG>gcA	p.A12A	RPS6KA5_ENST00000418736.2_Silent_p.A12A	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	12					axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		CGCTGGTCCCCGCGGCGCCGC	0.716000													4	4					0	0	1	0	0
GDNF	2668	broad.mit.edu	37	5	37834811	37834811	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr5:37834811C>T	ENST00000326524.2	-	2	287	c.88G>A	c.(88-90)Gag>Aag	p.E30K	GDNF_ENST00000381826.4_Intron|GDNF_ENST00000427982.1_Missense_Mutation_p.E47K|GDNF_ENST00000515058.1_Intron|GDNF_ENST00000344622.4_Intron	NM_000514.3	NP_000505.1	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor	30					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity			NS(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(8)|skin(2)	15	all_lung(31;0.00118)					GCGGGCGCCTCGGGAGGCCTC	0.706000													4	10					0	0	1	0	0
SPIN3	169981	broad.mit.edu	37	X	57021212	57021212	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chrX:57021212C>T	ENST00000374919.3	-	2	491	c.169G>A	c.(169-171)Gga>Aga	p.G57R		NM_001010862.2	NP_001010862.2	Q5JUX0	SPIN3_HUMAN	spindlin family, member 3	57					gamete generation					central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)	4						TCTTTCCATCCGTGCTGAATT	0.488000													39	120					0	0	1	0	0
RPL6	6128	broad.mit.edu	37	12	112844607	112844607	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr12:112844607C>T	ENST00000424576.2	-	4	609	c.424G>A	c.(424-426)Gcc>Acc	p.A142T	RPL6_ENST00000202773.9_Missense_Mutation_p.A142T	NM_001024662.1	NP_001019833.1	Q02878	RL6_HUMAN	ribosomal protein L6	142					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			cervix(1)|large_intestine(6)|lung(3)	10						GTAATGCTGGCTCGCAGTTTT	0.557000													9	43					0	0	1	0	0
CELA1	1990	broad.mit.edu	37	12	51723536	51723536	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr12:51723536C>T	ENST00000293636.1	-	7	731	c.691G>A	c.(691-693)Ggc>Agc	p.G231S		NM_001971.5	NP_001962.3	Q9UNI1	CELA1_HUMAN	chymotrypsin-like elastase family, member 1	231	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15						ACATTACAGCCCCGGCTGGAC	0.522000													25	41					0	0	1	0	0
ACSS1	84532	broad.mit.edu	37	20	25003680	25003680	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr20:25003680C>T	ENST00000537502.1	-	3	2138	c.607G>A	c.(607-609)Gag>Aag	p.E203K	ACSS1_ENST00000323482.4_Missense_Mutation_p.E286K|ACSS1_ENST00000432802.2_Missense_Mutation_p.E286K|ACSS1_ENST00000542618.1_Missense_Mutation_p.E165K			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	286					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGCATGTCCTCACTGCCCATG	0.597000													21	26					0	0	1	0	0
ZYG11B	79699	broad.mit.edu	37	1	53237368	53237368	+	Silent	SNP	T	T	C			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:53237368T>C	ENST00000294353.6	+	3	1018	c.873T>C	c.(871-873)cgT>cgC	p.R291R	ZYG11B_ENST00000443756.2_Silent_p.R291R|ZYG11B_ENST00000545132.1_Silent_p.R291R	NM_024646.2	NP_078922.1	Q9C0D3	ZY11B_HUMAN	zyg-11 family member B, cell cycle regulator	291							protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	30						TACAACAACGTCCAAGCATGC	0.403000													55	54					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17089531	17089531	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr10:17089531T>A	ENST00000377833.4	-	23	3276	c.3211A>T	c.(3211-3213)Aac>Tac	p.N1071Y		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1071	CUB 6.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CATTCCCAGTTGTTGGGATAA	0.423000													25	39					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8218509	8218509	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr17:8218509C>G	ENST00000361926.3	+	6	1284	c.1174C>G	c.(1174-1176)Cgc>Ggc	p.R392G	ARHGEF15_ENST00000421050.1_Missense_Mutation_p.R392G	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	392					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						CCCTGGACCTCGCAACACCCT	0.647000													7	14					0	0	1	0	0
TMEM30A	55754	broad.mit.edu	37	6	75968519	75968519	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr6:75968519C>T	ENST00000230461.6	-	6	1198	c.869G>A	c.(868-870)cGa>cAa	p.R290Q	TMEM30A_ENST00000475111.2_Missense_Mutation_p.R254Q|TMEM30A_ENST00000370050.5_Missense_Mutation_p.R171Q	NM_018247.3	NP_060717.1	Q9NV96	CC50A_HUMAN	transmembrane protein 30A	290						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(8)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CAAAGAGTATCGGCCAGCTGG	0.393000													14	24					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84104237	84104237	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr16:84104237G>C	ENST00000343411.3	-	13	2233	c.1738C>G	c.(1738-1740)Cag>Gag	p.Q580E		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	580					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						ACATGGCCCTGAGCAATGCCT	0.527000													13	79					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70405437	70405437	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr10:70405437C>T	ENST00000373644.4	+	4	3160	c.2951C>T	c.(2950-2952)tCa>tTa	p.S984L		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	984					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						CATATCAACTCAGCTACTAAC	0.358000													38	26					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38958617	38958617	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr5:38958617T>C	ENST00000357387.3	-	24	2378	c.2348A>G	c.(2347-2349)aAt>aGt	p.N783S	RICTOR_ENST00000296782.5_Missense_Mutation_p.N783S|RICTOR_ENST00000503698.1_5'UTR	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	783					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					AGCATGAAGATTGGCCTAAAA	0.308000													12	49					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116525965	116525965	+	Silent	SNP	T	T	C			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr2:116525965T>C	ENST00000410059.1	+	13	1686	c.1206T>C	c.(1204-1206)gcT>gcC	p.A402A	DPP10_ENST00000393147.2_Silent_p.A406A|DPP10_ENST00000409163.1_Silent_p.A352A|DPP10_ENST00000310323.8_Silent_p.A395A	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	402					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						ACCACGTAGCTATGTTCCTCA	0.453000													24	17					0	0	1	0	0
IGF2BP3	10643	broad.mit.edu	37	7	23383371	23383371	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr7:23383371C>T	ENST00000258729.3	-	9	1399	c.1043G>A	c.(1042-1044)aGg>aAg	p.R348K		NM_006547.2	NP_006538.2	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding protein 3	348					anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(2)|prostate(2)|skin(4)|stomach(1)	34						ATAAGACTCCCTGATTTTCTT	0.343000													18	115					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15928166	15928166	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr5:15928166C>G	ENST00000504595.1	+	3	776	c.295C>G	c.(295-297)Ccg>Gcg	p.P99A	FBXL7_ENST00000510662.1_Missense_Mutation_p.P52A|FBXL7_ENST00000329673.7_Missense_Mutation_p.P87A	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	99					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						CCTCACACACCCGCTCATCCG	0.652000													5	11					0	0	1	0	0
MFSD9	84804	broad.mit.edu	37	2	103353216	103353216	+	Silent	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr2:103353216C>T	ENST00000258436.5	-	1	97	c.54G>A	c.(52-54)gaG>gaA	p.E18E		NM_032718.3	NP_116107.3	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing 9	18					transmembrane transport	integral to membrane|plasma membrane	transporter activity			breast(3)|large_intestine(7)|liver(1)|lung(6)|ovary(2)|skin(1)	20						GCTCTGCGGTCTCCGAGACCA	0.692000													16	10					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369339.3_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													5	181					0	0	1	0	0
KRTAP26-1	388818	broad.mit.edu	37	21	31691849	31691849	+	Silent	SNP	A	A	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr21:31691849A>G	ENST00000360542.3	-	1	758	c.505T>C	c.(505-507)Ttg>Ctg	p.L169L		NM_203405.1	NP_981950.1	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	169						intermediate filament				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16						CGATAGGCCAAGCAACTCGAG	0.557000													80	114					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664115	22664115	+	RNA	SNP	A	A	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr22:22664115A>T	ENST00000426066.1	+	0	638					NR_027293.1																						TGTTTAATTCAGCCTTGGAAG	0.413000													3	52					0	0	1	0	0
EPS8L2	64787	broad.mit.edu	37	11	720123	720123	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr11:720123G>A	ENST00000533256.1	+	6	602	c.227G>A	c.(226-228)cGg>cAg	p.R76Q	AP006621.9_ENST00000527021.2_RNA|EPS8L2_ENST00000318562.8_Missense_Mutation_p.R76Q|EPS8L2_ENST00000526198.1_Missense_Mutation_p.R76Q|EPS8L2_ENST00000530636.1_Missense_Mutation_p.R76Q			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	76	PID.					cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GACGCCATCCGGAAGCTGGTG	0.617000													6	16					0	0	1	0	0
ZRANB3	84083	broad.mit.edu	37	2	136111039	136111039	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr2:136111039G>A	ENST00000401392.1	-	4	552	c.340C>T	c.(340-342)Cag>Tag	p.Q114*	ZRANB3_ENST00000264159.6_Nonsense_Mutation_p.Q114*|ZRANB3_ENST00000536680.1_Nonsense_Mutation_p.Q114*			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	114	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		GTTTTATTCTGAATAACATTG	0.358000													13	9					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34505471	34505471	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr20:34505471G>C	ENST00000374012.3	+	13	2020	c.1891G>C	c.(1891-1893)Gat>Cat	p.D631H	PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	631					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					GTATGGCCAAGATGTGGATGT	0.473000													25	28					0	0	1	0	0
DONSON	29980	broad.mit.edu	37	21	34953734	34953734	+	Silent	SNP	G	G	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr21:34953734G>A	ENST00000453626.1	-	8	1228	c.1224C>T	c.(1222-1224)acC>acT	p.T408T	DONSON_ENST00000432378.1_Silent_p.T408T|DONSON_ENST00000303071.5_Silent_p.T408T|DONSON_ENST00000303113.6_Silent_p.T394T			Q9NYP3	DONS_HUMAN	downstream neighbor of SON	408					multicellular organismal development	nucleus				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|ovary(1)	11						GCAATGTAAAGGTGTTGATTC	0.413000													10	23					0	0	1	0	0
FOXQ1	94234	broad.mit.edu	37	6	1313398	1313398	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr6:1313398C>A	ENST00000296839.2	+	1	724	c.459C>A	c.(457-459)ttC>ttA	p.F153L		NM_033260.3	NP_150285.3	Q9C009	FOXQ1_HUMAN	forkhead box Q1	153					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			lung(1)|urinary_tract(1)	2	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		TGGGCAAGTTCCCCTTTTTCC	0.657000													19	16					4.96729e-08	5.13105e-08	1	1	0
KCNE4	23704	broad.mit.edu	37	2	223918016	223918016	+	Silent	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr2:223918016C>T	ENST00000281830.3	+	2	952	c.621C>T	c.(619-621)aaC>aaT	p.N207N	KCNE4_ENST00000488477.2_Intron|KCNE4_ENST00000604125.1_Silent_p.N156N			Q8WWG9	KCNE4_HUMAN	potassium voltage-gated channel, Isk-related family, member 4	156						integral to membrane	voltage-gated potassium channel activity			large_intestine(2)|lung(5)|ovary(2)|skin(1)	10		Renal(207;0.0183)|Lung NSC(271;0.137)|all_lung(227;0.175)		Epithelial(121;4.48e-11)|all cancers(144;2.88e-08)|Lung(261;0.00688)|LUSC - Lung squamous cell carcinoma(224;0.008)		CGCCCCTCAACGAGAGCAGCG	0.627000													7	7					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96730107	96730107	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr14:96730107C>T	ENST00000216629.6	+	3	694	c.88C>T	c.(88-90)Cca>Tca	p.P30S	RP11-404P21.3_ENST00000553638.1_RNA|RP11-404P21.8_ENST00000555847.1_3'UTR|BDKRB1_ENST00000553356.1_Missense_Mutation_p.P30S|RP11-404P21.8_ENST00000553811.1_3'UTR	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	30					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		TGACAATGCTCCAGAAGCCTG	0.537000													22	17					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803746	142803746	+	RNA	SNP	A	A	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:142803746A>G	ENST00000423385.1	-	0	1219																											actatggattagagctgatta	0.393000													3	4					0	0	1	0	0
RHOB	388	broad.mit.edu	37	2	20647363	20647363	+	Missense_Mutation	SNP	T	T	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr2:20647363T>G	ENST00000272233.4	+	1	529	c.137T>G	c.(136-138)aTt>aGt	p.I46S		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	46					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GTGGCCGACATTGAGGTGGAC	0.652000													48	48					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51780819	51780819	+	Silent	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr15:51780819C>T	ENST00000251076.5	-	21	5264	c.4977G>A	c.(4975-4977)agG>agA	p.R1659R	RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000449909.3_Silent_p.R1023R|DMXL2_ENST00000543779.2_Silent_p.R1659R	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1659						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		CATCATTGTTCCTTTGAAAAG	0.333000													13	43					0	0	1	0	0
MSL3	10943	broad.mit.edu	37	X	11786764	11786764	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chrX:11786764C>T	ENST00000380693.3	+	9	1383	c.746C>T	c.(745-747)gCt>gTt	p.A249V	MSL3_ENST00000398527.2_Missense_Mutation_p.A403V|MSL3_ENST00000361672.2_Missense_Mutation_p.A266V|MSL3_ENST00000312196.4_Missense_Mutation_p.A415V|MSL3_ENST00000467141.1_3'UTR	NM_006800.3	NP_006791.2	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3 homolog (Drosophila)	415					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	19						GCTGTGTTTGCTGGCTTTGAA	0.378000													19	55					0	0	1	0	0
HECTD2	143279	broad.mit.edu	37	10	93252138	93252138	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr10:93252138G>C	ENST00000446394.1	+	14	1441	c.1341G>C	c.(1339-1341)aaG>aaC	p.K447N	HECTD2_ENST00000536715.1_Missense_Mutation_p.K32N|HECTD2_ENST00000298068.5_Missense_Mutation_p.K443N|HECTD2_ENST00000371667.1_Missense_Mutation_p.K93N	NM_001284274.1	NP_001271203.1	Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	443	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						ATTTGAAAAAGAAGTTAAAAG	0.348000													17	78					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32932942	32932942	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr3:32932942C>A	ENST00000383763.5	+	4	2309	c.2246C>A	c.(2245-2247)tCc>tAc	p.S749Y		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase						multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CACTTTGACTCCCCACGGGGT	0.582000													28	23					6.32553e-13	6.75682e-13	1	1	0
ZYG11B	79699	broad.mit.edu	37	1	53237356	53237356	+	Silent	SNP	T	T	C			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:53237356T>C	ENST00000294353.6	+	3	1006	c.861T>C	c.(859-861)ttT>ttC	p.F287F	ZYG11B_ENST00000443756.2_Silent_p.F287F|ZYG11B_ENST00000545132.1_Silent_p.F287F	NM_024646.2	NP_078922.1	Q9C0D3	ZY11B_HUMAN	zyg-11 family member B, cell cycle regulator	287							protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	30						TTGAAGCCTTTATACAACAAC	0.428000													54	50					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128277	152128280	+	Frame_Shift_Del	DEL	TGTC	TGTC	-			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:152128277_152128280delTGTC	ENST00000316073.3	-	3	1359_1362	c.1295_1298delGACA	c.(1294-1299)agacaafs	p.RQ432fs		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	432	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding	p.R432K(1)		breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						ACTCTGGCCTTGTCTGTCTGTCTG	0.525													7	1121	---	---	---	---					
ELF3	1999	broad.mit.edu	37	1	201982416	201982417	+	Frame_Shift_Ins	INS	-	-	A			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr1:201982416_201982417insA	ENST00000359651.3	+	6	3987_3988	c.795_796insA	c.(796-798)agcfs	p.S266fs	ELF3_ENST00000367284.5_Frame_Shift_Ins_p.S266fs|ELF3_ENST00000367283.3_Frame_Shift_Ins_p.S266fs|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	266					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						AGGGCAAGAAGAGCAAGCACGG	0.639													36	60	---	---	---	---					
NMI	9111	broad.mit.edu	37	2	152128201	152128201	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr2:152128201delT	ENST00000243346.5	-	7	1150	c.680delA	c.(679-681)aatfs	p.N227fs		NM_004688.2	NP_004679.2	Q13287	NMI_HUMAN	N-myc (and STAT) interactor	227					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				BRCA - Breast invasive adenocarcinoma(221;0.0571)		GCAGGTTTGATTTATATAAAG	0.308													37	27	---	---	---	---					
TRMT10C	54931	broad.mit.edu	37	3	101283718	101283722	+	Frame_Shift_Del	DEL	TAACT	TAACT	-			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr3:101283718_101283722delTAACT	ENST00000309922.6	+	2	247_251	c.93_97delTAACT	c.(91-99)aataacttafs	p.NL32fs		NM_017819.2	NP_060289.2			tRNA methyltransferase 10 homolog C (S. cerevisiae)																		GGAAGAGAAATAACTTAACAATTTT	0.380													51	123	---	---	---	---					
BHLHE41	79365	broad.mit.edu	37	12	26276595	26276596	+	Frame_Shift_Ins	INS	-	-	G			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr12:26276595_26276596insG	ENST00000242728.4	-	4	660_661	c.313_314insC	c.(313-315)caafs	p.Q105fs		NM_030762.2	NP_110389.1	Q9C0J9	BHE41_HUMAN	basic helix-loop-helix family, member e41	105					cell differentiation|cell proliferation|organ morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(1)	5						CTGATGCTGTTGCTCGGTTAAG	0.475											OREG0021711	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	30	---	---	---	---					
OAS2	4939	broad.mit.edu	37	12	113433126	113433130	+	Frame_Shift_Del	DEL	GATCT	GATCT	-			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr12:113433126_113433130delGATCT	ENST00000392583.2	+	3	681_685	c.474_478delGATCT	c.(472-480)tggatctatfs	p.WIY158fs	RP1-71H24.1_ENST00000552784.1_RNA|OAS2_ENST00000342315.4_Frame_Shift_Del_p.WIY158fs	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	158	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						CCAGCCCCTGGATCTATCGAGAGCT	0.434													14	84	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7577036	7577036	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr17:7577036delG	ENST00000420246.2	-	8	1034	c.902delC	c.(901-903)ccafs	p.P301fs	TP53_ENST00000359597.4_Frame_Shift_Del_p.P301fs|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Frame_Shift_Del_p.P301fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.P301fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.P301fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	301	Interaction with CARM1.|Interaction with HIPK1 (By similarity).		P -> A (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.G302fs*4(5)|p.?(3)|p.P301fs*44(2)|p.P301_S303delPGS(1)|p.L299fs*2(1)|p.P301fs*5(1)|p.L265_K305del41(1)|p.P301Q(1)|p.G293fs*1(1)|p.P301L(1)|p.E298_P301delELPP(1)|p.H296_S303delHHELPPGS(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGTGCTCCCTGGGGGCAGCTC	0.557		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	24	---	---	---	---					
EP300	2033	broad.mit.edu	37	22	41556700	41556700	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chr22:41556700delG	ENST00000263253.7	+	20	4864	c.3645delG	c.(3643-3645)ttgfs	p.L1215fs		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1215					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.Y1198_L1243del(1)		NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						GCGTTTCTTTGGGGGATGACC	0.428			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				31	38	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44820536	44820536	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chrX:44820536delG	ENST00000377967.4	+	3	274	c.233delG	c.(232-234)cgcfs	p.R78fs	KDM6A_ENST00000543216.1_Frame_Shift_Del_p.R78fs|KDM6A_ENST00000536777.1_Frame_Shift_Del_p.R78fs|KDM6A_ENST00000382899.4_Frame_Shift_Del_p.R78fs	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	78					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(14)|p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TAGGCTGTTCGCTGCTATGAA	0.333			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								18	49	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44918673	44918673	+	Frame_Shift_Del	DEL	A	A	-			TCGA-E7-A97Q-01A-11D-A38G-08	TCGA-E7-A97Q-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fd941f38-9b9c-471d-9cce-7081cc9cc9c1	0c28df77-b2bc-47ed-a7fd-6ea14b65823a	g.chrX:44918673delA	ENST00000377967.4	+	12	1197	c.1156delA	c.(1156-1158)aatfs	p.N386fs	KDM6A_ENST00000543216.1_Frame_Shift_Del_p.N386fs|KDM6A_ENST00000536777.1_Frame_Shift_Del_p.N386fs|KDM6A_ENST00000382899.4_Frame_Shift_Del_p.N386fs	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	386					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.0(2)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						AAGTTGTAGTAATACCTCTGC	0.408			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								22	37	---	---	---	---					
