Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNRD1-AS1	80862	broad.mit.edu	37	6	29976024	29976024	+	RNA	SNP	C	C	G	rs3765604	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr6:29976024C>G	ENST00000376797.3	-	0	1053				ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA																							ATAACGAGGTCCTGGGTTCTG	0.592000													8	29					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55212787	55212787	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:55212787C>T	ENST00000447346.2	+	15	2199	c.2134C>T	c.(2134-2136)Cgc>Tgc	p.R712C	IL31RA_ENST00000490985.1_Missense_Mutation_p.R570C|IL31RA_ENST00000396834.1_Intron|IL31RA_ENST00000354961.4_Intron|IL31RA_ENST00000359040.5_Intron	NM_001242636.1|NM_139017.5	NP_001229565.1|NP_620586.3	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	680					anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				AGAGGGGACCCGCCCAGAAGC	0.483000													11	49					0	0	1	0	0
CCKBR	887	broad.mit.edu	37	11	6290930	6290930	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr11:6290930C>T	ENST00000525462.1	+	2	186	c.183C>T	c.(181-183)taC>taT	p.Y61Y	CCKBR_ENST00000532715.1_Intron|CCKBR_ENST00000531712.1_3'UTR|CCKBR_ENST00000525014.1_Silent_p.Y61Y|CCKBR_ENST00000334619.2_Silent_p.Y61Y			P32239	GASR_HUMAN	cholecystokinin B receptor	61					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TCACTCTTTACGCAGTGATCT	0.532000													17	64					0	0	1	0	0
WASF2	10163	broad.mit.edu	37	1	27736473	27736473	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:27736473G>A	ENST00000430629.2	-	8	1267	c.1052C>T	c.(1051-1053)tCa>tTa	p.S351L	WASF2_ENST00000536657.1_Intron	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	351					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		AGATGGGGGTGAGGGTGGTGG	0.637000													13	55					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	241094020	241094020	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:241094020A>T	ENST00000366565.1	-	6	763	c.382T>A	c.(382-384)Tat>Aat	p.Y128N	RGS7_ENST00000366563.1_Missense_Mutation_p.Y128N|RGS7_ENST00000407727.1_Missense_Mutation_p.Y128N|RGS7_ENST00000401882.1_Intron|RGS7_ENST00000331110.7_Missense_Mutation_p.Y102N|RGS7_ENST00000446183.2_Missense_Mutation_p.Y44N|RGS7_ENST00000348120.2_Intron|RGS7_ENST00000366564.1_Missense_Mutation_p.Y128N|RGS7_ENST00000366562.4_Missense_Mutation_p.Y128N	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	128					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CACTGACCATAATCTGTGTTT	0.373000													131	96					0	0	1	0	0
UBA6	55236	broad.mit.edu	37	4	68514897	68514897	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:68514897G>A	ENST00000322244.5	-	14	1196	c.1137C>T	c.(1135-1137)ctC>ctT	p.L379L		NM_018227.5	NP_060697.4	A0AVT1	UBA6_HUMAN	ubiquitin-like modifier activating enzyme 6						protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						CAGTCCAAGAGAGCCAATGCA	0.393000													13	65					0	0	1	0	0
OR2T1	26696	broad.mit.edu	37	1	248569879	248569879	+	Missense_Mutation	SNP	T	T	A	rs138350213		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:248569879T>A	ENST00000366474.1	+	1	584	c.584T>A	c.(583-585)aTa>aAa	p.I195K		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGATGATTATAGCAGGTTCC	0.537000													15	139					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170011072	170011072	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:170011072G>A	ENST00000263816.3	-	66	12478	c.12193C>T	c.(12193-12195)Cga>Tga	p.R4065*		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4065					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTATATTTTCGAATTCGGACA	0.378000													29	58					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140969332	140969332	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:140969332G>A	ENST00000298296.1	+	4	659	c.659G>A	c.(658-660)gGc>gAc	p.G220D	MAGEC3_ENST00000443323.2_Intron|MAGEC3_ENST00000448920.1_Intron|MAGEC3_ENST00000536088.1_Intron	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	220	MAGE 1.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					ACATACACGGGCTACTTTCCT	0.438000													56	47					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27447754	27447754	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:27447754G>A	ENST00000527372.1	-	7	1788	c.1608C>T	c.(1606-1608)taC>taT	p.Y536Y	MYO18A_ENST00000354329.4_Silent_p.Y536Y|MYO18A_ENST00000533112.1_Silent_p.Y536Y|MYO18A_ENST00000531253.1_Silent_p.Y536Y	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	536	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CCAGGAGGGTGTACAGAGCCT	0.577000													9	59					0	0	1	0	0
IZUMO2	126123	broad.mit.edu	37	19	50666025	50666025	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:50666025G>A	ENST00000293405.3	-	2	278	c.278C>T	c.(277-279)aCg>aTg	p.T93M		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	93						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						TAAGTGCTGCGTTTGGTTCTT	0.567000													10	48					0	0	1	0	0
PDCL	5082	broad.mit.edu	37	9	125585294	125585294	+	Splice_Site	SNP	C	C	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr9:125585294C>A	ENST00000259467.4	-	3	520		c.e3+1			NM_005388.4	NP_005379.3	Q13371	PHLP_HUMAN	phosducin-like						signal transduction|visual perception					endometrium(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	10						CTGCTAATTACCTTCCCACTG	0.483000													42	60					3.54561e-26	3.87335e-26	1	1	0
CLSTN2	64084	broad.mit.edu	37	3	140282913	140282913	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:140282913G>A	ENST00000458420.3	+	16	2783	c.2593G>A	c.(2593-2595)Gag>Aag	p.E865K		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	865					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CTTCATCCAGGAGACTGAGGC	0.562000										HNSCC(16;0.037)			27	125					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179532370	179532370	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:179532370G>A	ENST00000589042.1	-	160	35848	c.35624C>T	c.(35623-35625)gCa>gTa	p.A11875V	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10008	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATACCTTTTGCTAGTTTGGG	0.294000													18	104					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7117211	7117211	+	Silent	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:7117211A>G	ENST00000341500.5	-	21	4008	c.3969T>C	c.(3967-3969)tgT>tgC	p.C1323C	INSR_ENST00000302850.5_Silent_p.C1335C	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1335					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCTCCCTCTGACAGTGCGAGG	0.597000													29	56					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14767865	14767865	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:14767865C>T	ENST00000261170.3	-	26	3119	c.2983G>A	c.(2983-2985)Gag>Aag	p.E995K	RP11-695J4.2_ENST00000545424.1_RNA|RP11-695J4.2_ENST00000542401.1_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	995					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						TAGGTAGTCTCATTTCCTCTT	0.483000													4	21					0	0	1	0	0
OMP	4975	broad.mit.edu	37	11	76814045	76814045	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr11:76814045C>T	ENST00000529803.1	+	1	160	c.160C>T	c.(160-162)Cgc>Tgc	p.R54C	CAPN5_ENST00000278559.3_Intron|CAPN5_ENST00000456580.2_Intron|CAPN5_ENST00000531028.1_Intron|CAPN5_ENST00000529629.1_Intron	NM_006189.1	NP_006180.1	P47874	OMP_HUMAN	olfactory marker protein	54					sensory perception of smell|synaptic transmission			p.R54C(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						GTCTGTGTACCGCCTCAACTT	0.637000													6	30					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43930620	43930620	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:43930620G>C	ENST00000262726.7	-	30	4434	c.4181C>G	c.(4180-4182)gCa>gGa	p.A1394G	EFCAB6_ENST00000461800.1_5'UTR|EFCAB6_ENST00000396231.2_Missense_Mutation_p.A1242G|EFCAB6-AS1_ENST00000431327.3_RNA	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1394	EF-hand 15.|Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GCTTTCCTTTGCTTTTAGCAG	0.473000													4	53					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51266209	51266209	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:51266209A>T	ENST00000266037.9	+	18	1788	c.1765A>T	c.(1765-1767)Aaa>Taa	p.K589*		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	589	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GCGCAGCACCAAAGAGTCTTT	0.517000													14	43					0	0	1	0	0
BCL2L13	23786	broad.mit.edu	37	22	18210180	18210180	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:18210180C>T	ENST00000317582.5	+	7	1685	c.1338C>T	c.(1336-1338)gcC>gcT	p.A446A	BCL2L13_ENST00000337612.5_Silent_p.A284A|BCL2L13_ENST00000485631.1_3'UTR|BCL2L13_ENST00000538149.1_Silent_p.A322A|BCL2L13_ENST00000418951.2_3'UTR|BCL2L13_ENST00000543133.1_Silent_p.A284A|BCL2L13_ENST00000355028.3_3'UTR	NM_015367.3	NP_056182.2	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	446					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			breast(2)|central_nervous_system(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(3)|urinary_tract(2)	15		all_epithelial(15;0.123)		Lung(27;0.199)		TGTCCCCCGCCGGTGAGATGA	0.612000													23	79					0	0	1	0	0
LIPA	3988	broad.mit.edu	37	10	91007301	91007301	+	Missense_Mutation	SNP	C	C	T	rs145756015		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:91007301C>T	ENST00000336233.5	-	2	427	c.105G>A	c.(103-105)atG>atA	p.M35I	LIPA_ENST00000371837.1_Intron|LIPA_ENST00000456827.1_Missense_Mutation_p.M35I			P38571	LICH_HUMAN	lipase A, lysosomal acid, cholesterol esterase	35					lipid catabolic process	lysosome	lipase activity|sterol esterase activity			endometrium(1)|large_intestine(2)|lung(3)	6		Colorectal(252;0.0162)		GBM - Glioblastoma multiforme(2;0.00406)		TTACCACATTCATGTTTGTTT	0.438000													4	21					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25321010	25321010	+	RNA	SNP	G	G	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr15:25321010G>T	ENST00000549804.2	+	0	1106																											GATACCTCAGGATGGTAAGTA	0.463000													12	41					1.61879e-10	1.72494e-10	1	1	0
ATP7A	538	broad.mit.edu	37	X	77268496	77268496	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:77268496C>T	ENST00000341514.6	+	10	2448	c.2293C>T	c.(2293-2295)Ctt>Ttt	p.L765F	ATP7A_ENST00000343533.5_Intron|ATP7A_ENST00000350425.4_Intron	NM_000052.5	NP_000043.4	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	765					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						TTTGATTATTCTTCTAGTTGC	0.423000													59	61					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49699204	49699204	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:49699204C>T	ENST00000303221.5	-	6	900	c.685G>A	c.(685-687)Gag>Aag	p.E229K	EMB_ENST00000508934.1_Missense_Mutation_p.E175K|EMB_ENST00000506190.1_5'UTR|EMB_ENST00000514111.1_Missense_Mutation_p.E179K	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	229	Ig-like V-type 2.					integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				CCATCTTCCTCCAAAAGTTGT	0.418000													13	57					0	0	1	0	0
RASA1	5921	broad.mit.edu	37	5	86679590	86679590	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:86679590C>T	ENST00000456692.2	+	21	2335	c.2220C>T	c.(2218-2220)atC>atT	p.I740I	RASA1_ENST00000274376.6_Silent_p.I917I|RASA1_ENST00000506290.1_Silent_p.I751I|RASA1_ENST00000512763.1_Silent_p.I750I	NM_022650.2	NP_072179.1	P20936	RASA1_HUMAN	RAS p21 protein activator (GTPase activating protein) 1	917					cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TGTTCAATATCATCTCAGGTA	0.274000													5	20					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48755296	48755296	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:48755296C>T	ENST00000285238.8	+	24	3650	c.3570C>T	c.(3568-3570)atC>atT	p.I1190I		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1190	ABC transmembrane type-1 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCTACATCATCTCCAACCGGT	0.577000													21	149					0	0	1	0	0
ZCCHC8	55596	broad.mit.edu	37	12	122958344	122958344	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:122958344C>G	ENST00000543897.1	-	12	3465	c.1110G>C	c.(1108-1110)caG>caC	p.Q370H	ZCCHC8_ENST00000336229.4_Missense_Mutation_p.Q608H|ZCCHC8_ENST00000538116.1_Missense_Mutation_p.Q219H|ZCCHC8_ENST00000536306.1_Missense_Mutation_p.Q370H			Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	608						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		CTTTTTCCTTCTGACAAAGTG	0.493000													52	147					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263361	140263361	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:140263361C>A	ENST00000289272.2	+	1	1508	c.1508C>A	c.(1507-1509)gCg>gAg	p.A503E	PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.A503E|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA12_ENST00000398631.2_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAGCGTGCGCTGTCGAGC	0.672000													19	65					0.000132079	0.000136272	1	1	0
CLIP3	25999	broad.mit.edu	37	19	36508845	36508845	+	Missense_Mutation	SNP	C	C	T	rs149100841		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:36508845C>T	ENST00000360535.4	-	10	1459	c.1232G>A	c.(1231-1233)cGt>cAt	p.R411H	CLIP3_ENST00000593074.1_Missense_Mutation_p.R411H|AC002116.7_ENST00000586962.1_RNA	NM_015526.2	NP_056341.1	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	411					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			cervix(1)|endometrium(6)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	23	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGCCCCGTCACGCTGCTGCAA	0.612000													14	49					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8188893	8188893	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:8188893C>G	ENST00000600128.1	-	23	3146		c.e23-1		FBN3_ENST00000601739.1_Splice_Site|FBN3_ENST00000270509.2_Splice_Site			Q75N90	FBN3_HUMAN	fibrillin 3							proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						AATCTCACATCTGCACGGGGG	0.617000													9	15					0	0	1	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545237	234545237	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:234545237C>T	ENST00000344644.5	+	1	138	c.69C>T	c.(67-69)gcC>gcT	p.A23A	UGT1A1_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Silent_p.A23A	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		GTGGCTTTGCCGAGGCAGGGA	0.597000													26	89					0	0	1	0	0
MBIP	51562	broad.mit.edu	37	14	36789701	36789701	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr14:36789701C>T	ENST00000416007.4	-	1	181	c.94G>A	c.(94-96)Gaa>Aaa	p.E32K	MBIP_ENST00000318473.7_Missense_Mutation_p.E32K|MBIP_ENST00000359527.7_Missense_Mutation_p.E32K	NM_001144891.1|NM_016586.2	NP_001138363.1|NP_057670.2	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1	32					histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity			breast(2)|large_intestine(1)|lung(5)	8	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)		CGAAAGATTTCGTAGAGCACC	0.567000													9	30					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122419588	122419588	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:122419588C>G	ENST00000474629.2	+	6	2453	c.2187C>G	c.(2185-2187)gaC>gaG	p.D729E		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	729					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		AGGCAGTGGACATTGTCAAGC	0.408000													3	22					0	0	1	0	0
ENPP1	5167	broad.mit.edu	37	6	132204911	132204911	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr6:132204911C>G	ENST00000360971.2	+	22	2328	c.2308C>G	c.(2308-2310)Caa>Gaa	p.Q770E		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	770	Nuclease.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	CCAGAGTTTTCAAGGTAAATA	0.274000													21	44					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24873643	24873643	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:24873643G>A	ENST00000396432.2	-	26	6061	c.5575C>T	c.(5575-5577)Cgc>Tgc	p.R1859C		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1858	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						GTACTGGTGCGTAGGCGTTCC	0.527000													18	74					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875460	247875460	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:247875460A>G	ENST00000302084.2	-	1	645	c.598T>C	c.(598-600)Ttt>Ctt	p.F200L	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GCAATCACAAAGGCCACAAGC	0.537000													20	144					0	0	1	0	0
DNAJC11	55735	broad.mit.edu	37	1	6696194	6696194	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:6696194A>G	ENST00000377577.5	-	15	1760	c.1637T>C	c.(1636-1638)cTc>cCc	p.L546P	DNAJC11_ENST00000377573.5_Missense_Mutation_p.L456P|DNAJC11_ENST00000349363.6_Intron|DNAJC11_ENST00000294401.7_Missense_Mutation_p.L494P|DNAJC11_ENST00000542246.1_Missense_Mutation_p.L508P|DNAJC11_ENST00000465508.1_5'UTR	NM_018198.3	NP_060668.2	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	546					protein folding		heat shock protein binding|unfolded protein binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)|urinary_tract(1)	32	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTATCCGGAGGGCCTCACT	0.607000													8	38					0	0	1	0	0
ELF2	1998	broad.mit.edu	37	4	139980487	139980487	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:139980487G>C	ENST00000394235.2	-	10	1898	c.1396C>G	c.(1396-1398)Ctg>Gtg	p.L466V	ELF2_ENST00000265495.4_Missense_Mutation_p.L466V|ELF2_ENST00000510408.1_Missense_Mutation_p.L406V|ELF2_ENST00000515489.1_Intron|ELF2_ENST00000379550.1_Missense_Mutation_p.L478V|ELF2_ENST00000379549.2_Missense_Mutation_p.L389V|ELF2_ENST00000358635.3_Missense_Mutation_p.L418V	NM_001276458.1	NP_001263387.1	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription factor)	478					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	19	all_hematologic(180;0.162)					GATCCAGTCAGATTTGACTTT	0.443000													18	72					0	0	1	0	0
ZCWPW1	55063	broad.mit.edu	37	7	100013666	100013666	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr7:100013666C>T	ENST00000398027.2	-	8	930	c.683G>A	c.(682-684)cGa>cAa	p.R228Q	ZCWPW1_ENST00000360951.4_Missense_Mutation_p.R229Q|ZCWPW1_ENST00000324725.6_Missense_Mutation_p.R108Q|ZCWPW1_ENST00000490721.1_Missense_Mutation_p.R108Q	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	228							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTTCTTTAGTCGGTCTTCCTG	0.443000													11	130					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55816954	55816954	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:55816954G>C	ENST00000309383.1	+	16	2167	c.1890G>C	c.(1888-1890)tcG>tcC	p.S630S	BRSK1_ENST00000590333.1_Splice_Site_p.S646S|BRSK1_ENST00000326848.7_Splice_Site_p.S325S	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	630					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity	p.S630S(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CCTTTCTGTCGGTGAGGGGCC	0.557000													55	162					0	0	1	0	0
GBP6	163351	broad.mit.edu	37	1	89845982	89845982	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:89845982G>A	ENST00000370456.4	+	6	756	c.663G>A	c.(661-663)agG>agA	p.R221R	GBP6_ENST00000535065.1_Silent_p.R91R	NM_198460.2	NP_940862.2	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	221							GTP binding|GTPase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		ATTTTCCCAGGGAGTGCATCA	0.408000													7	74					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33572681	33572681	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr20:33572681G>C	ENST00000262873.7	+	10	891	c.799G>C	c.(799-801)Gag>Cag	p.E267Q		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	225	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TCAAATCATCGAGGCCAACCC	0.647000													15	50					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169344916	169344916	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:169344916G>A	ENST00000511577.1	-	15	2187	c.1940C>T	c.(1939-1941)tCg>tTg	p.S647L	DDX60L_ENST00000505890.1_Missense_Mutation_p.S647L|DDX60L_ENST00000260184.7_Missense_Mutation_p.S647L			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	647							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TAAATCTTTCGAAATTTTGCC	0.308000													3	9					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168107280	168107280	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:168107280A>G	ENST00000409195.1	+	9	9467	c.9378A>G	c.(9376-9378)atA>atG	p.I3126M	XIRP2_ENST00000409273.1_Missense_Mutation_p.I2904M|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.I3126M|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2951					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TTATCACAATAGAATCTACTG	0.443000													18	86					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79375841	79375841	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:79375841G>A	ENST00000350881.2	+	20	2815	c.2625G>A	c.(2623-2625)tgG>tgA	p.W875*	CTD-2201I18.1_ENST00000514042.1_RNA|THBS4_ENST00000511733.1_Nonsense_Mutation_p.W784*|THBS4_ENST00000504720.1_3'UTR|CTD-2201I18.1_ENST00000503007.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	875	TSP C-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		ATGTGGGCTGGAAGGACAAGG	0.597000													9	34					0	0	1	0	0
DPY19L4	286148	broad.mit.edu	37	8	95751649	95751649	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr8:95751649G>A	ENST00000414645.2	+	5	451	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	118						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					AGGTGTTTACGAACTGACACA	0.313000													7	103					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640412	179640412	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:179640412G>A	ENST00000589042.1	-	28	6403	c.6179C>T	c.(6178-6180)aCg>aTg	p.T2060M	TTN_ENST00000360870.5_Missense_Mutation_p.T2060M|TTN_ENST00000342175.6_Missense_Mutation_p.T2014M|TTN_ENST00000591111.1_Missense_Mutation_p.T2060M|TTN_ENST00000359218.5_Missense_Mutation_p.T2014M|TTN_ENST00000460472.2_Missense_Mutation_p.T2014M|TTN_ENST00000342992.6_Missense_Mutation_p.T2060M	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1829							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTGGAATCGTGATTTTGCC	0.423000													17	110					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126239451	126239451	+	Silent	SNP	C	C	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:126239451C>A	ENST00000394329.3	+	1	1898	c.1885C>A	c.(1885-1887)Cgg>Agg	p.R629R		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	629	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGAGACTGACCGGAGGTCCTT	0.557000													18	51					1.67942e-08	1.77499e-08	1	1	0
CD6	923	broad.mit.edu	37	11	60781397	60781397	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr11:60781397C>T	ENST00000313421.7	+	8	1484	c.1298C>T	c.(1297-1299)cCc>cTc	p.P433L	CD6_ENST00000352009.5_Intron|CD6_ENST00000452451.2_Missense_Mutation_p.P433L|CD6_ENST00000545105.1_3'UTR|CD6_ENST00000346437.4_Intron|CD6_ENST00000344028.5_Intron	NM_006725.4	NP_006716.3	P30203	CD6_HUMAN	CD6 molecule	433					cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)	18						TCAGCCCTCCCCGTAATGGTG	0.557000													6	29					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47531966	47531966	+	Silent	SNP	G	G	C	rs143583433	by1000genomes	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr21:47531966G>C	ENST00000300527.4	+	3	293	c.189G>C	c.(187-189)acG>acC	p.T63T	COL6A2_ENST00000409416.1_Silent_p.T63T|COL6A2_ENST00000397763.1_Silent_p.T63T|COL6A2_ENST00000310645.5_Silent_p.T63T|COL6A2_ENST00000357838.4_Silent_p.T63T	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	63	Nonhelical region.|VWFA 1.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AGTCCCCCACGGACATCCTGC	0.612000													25	55					0	0	1	0	0
FGF14	2259	broad.mit.edu	37	13	102527614	102527614	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr13:102527614A>G	ENST00000376131.4	-	2	336	c.241T>C	c.(241-243)Tat>Cat	p.Y81H	FGF14_ENST00000376143.4_Missense_Mutation_p.Y76H|FGF14_ENST00000468052.1_5'UTR	NM_175929.2	NP_787125.1	Q92915	FGF14_HUMAN	fibroblast growth factor 14	76					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)	29	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGCCTGCAATATAACCTGGTC	0.448000													12	45					0	0	1	0	0
PGM1	5236	broad.mit.edu	37	1	64117350	64117350	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:64117350G>A	ENST00000371083.4	+	9	1713	c.1345G>A	c.(1345-1347)Gag>Aag	p.E449K	PGM1_ENST00000371084.3_Missense_Mutation_p.E431K|PGM1_ENST00000540265.1_Missense_Mutation_p.E234K|PGM1_ENST00000483707.1_3'UTR	NM_001172818.1	NP_001166289.1	P36871	PGM1_HUMAN	phosphoglucomutase 1	431					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20						GTATGATTACGAGGAGGTGGA	0.498000													10	20					0	0	1	0	0
VWC2	375567	broad.mit.edu	37	7	49951714	49951714	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr7:49951714A>T	ENST00000340652.4	+	4	1467	c.911A>T	c.(910-912)tAt>tTt	p.Y304F	ZPBP_ENST00000491129.1_Intron	NM_198570.3	NP_940972.2	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2						negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space				cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8						CACTGTACTTATGAGGAAGGC	0.493000													14	40					0	0	1	0	0
PHGDH	26227	broad.mit.edu	37	1	120254678	120254678	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:120254678C>T	ENST00000369409.4	+	1	169	c.33C>T	c.(31-33)atC>atT	p.I11I		NM_006623.3	NP_006614.2	O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	11					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	18	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	AAGTGCTCATCAGTGACAGCC	0.552000													13	53					0	0	1	0	0
ROCK2	9475	broad.mit.edu	37	2	11367412	11367412	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:11367412G>A	ENST00000315872.6	-	6	1284	c.836C>T	c.(835-837)tCt>tTt	p.S279F	ROCK2_ENST00000401753.1_Missense_Mutation_p.S36F	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	279	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AACACCTACAGACCACCAATC	0.363000													53	113					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140140011	140140011	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:140140011C>T	ENST00000458420.3	+	5	872	c.682C>T	c.(682-684)Cag>Tag	p.Q228*		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	228	Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CAAACAACACCAGTATGAGAT	0.502000										HNSCC(16;0.037)			34	97					0	0	1	0	0
FAM131A	131408	broad.mit.edu	37	3	184062488	184062488	+	Silent	SNP	C	C	T	rs150189351	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:184062488C>T	ENST00000310585.4	+	3	2102	c.738C>T	c.(736-738)ggC>ggT	p.G246G	EIF2B5_ENST00000444495.1_Intron|FAM131A_ENST00000383847.2_Silent_p.G277G|FAM131A_ENST00000340957.5_Silent_p.G192G|FAM131A_ENST00000418281.1_Silent_p.G154G|FAM131A_ENST00000453072.1_Silent_p.G192G|FAM131A_ENST00000450976.1_Silent_p.G192G			Q6UXB0	F131A_HUMAN	family with sequence similarity 131, member A	246						extracellular region		p.G246G(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(9)|skin(1)	14	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGCTGCTGGGCGATGAGCTGC	0.667000													9	100					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	266745	266745	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:266745C>T	ENST00000538872.1	+	7	2446	c.2328C>T	c.(2326-2328)ccC>ccT	p.P776P	IQSEC3_ENST00000326261.4_Silent_p.P776P|IQSEC3_ENST00000382841.2_Silent_p.P473P			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	776	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TCCACAACCCCGACACCATCT	0.602000													5	84					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr16:90161902A>G	ENST00000567960.1	+	0	638				TUBB8P7_ENST00000564451.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													5	44					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39604116	39604116	+	Missense_Mutation	SNP	T	T	A	rs142592344	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr8:39604116T>A	ENST00000265708.4	-	19	2152	c.2049A>T	c.(2047-2049)aaA>aaT	p.K683N	ADAM2_ENST00000379853.2_Missense_Mutation_p.K527N|ADAM2_ENST00000347580.4_Missense_Mutation_p.K664N|ADAM2_ENST00000521880.1_Missense_Mutation_p.K620N	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	683					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ATCTCATTGGTTTGGAATGGT	0.299000													23	113					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125526589	125526589	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:125526589T>C	ENST00000241305.3	-	10	1533	c.1379A>G	c.(1378-1380)aAc>aGc	p.N460S	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	460					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GAGCAGCGTGTTTAAATCAGG	0.527000													12	57					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2876065	2876065	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr8:2876065C>T	ENST00000520002.1	-	53	8521	c.7966G>A	c.(7966-7968)Gtg>Atg	p.V2656M	CSMD1_ENST00000602723.1_Intron|CSMD1_ENST00000537824.1_Missense_Mutation_p.V2655M|CSMD1_ENST00000400186.3_Intron|CSMD1_ENST00000542608.1_Intron|CSMD1_ENST00000602557.1_Missense_Mutation_p.V2656M			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2656	Sushi 17.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGAGACCCCACAAGCGTGTAG	0.498000													69	108					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31137576	31137576	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:31137576C>T	ENST00000452305.1	-	8	2291	c.1728G>A	c.(1726-1728)ctG>ctA	p.L576L	ZNF438_ENST00000361310.3_Silent_p.L586L|ZNF438_ENST00000413025.1_Silent_p.L586L|ZNF438_ENST00000444692.2_Silent_p.L576L|ZNF438_ENST00000442986.1_Silent_p.L586L|ZNF438_ENST00000538351.2_Silent_p.L537L|ZNF438_ENST00000331737.6_Silent_p.L576L|ZNF438_ENST00000375311.1_Silent_p.L150L|ZNF438_ENST00000436087.2_Silent_p.L586L	NM_001143770.1	NP_001137242.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	586					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				GCACTTCTTTCAGATGGCCAA	0.478000													31	88					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193130158	193130158	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:193130158G>A	ENST00000342695.4	-	27	3339	c.3017C>T	c.(3016-3018)gCc>gTc	p.A1006V	ATP13A4_ENST00000392443.3_Missense_Mutation_p.A987V|ATP13A4_ENST00000400270.2_Missense_Mutation_p.A22V|ATP13A4_ENST00000482964.1_5'UTR	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1006					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TACTGTGCAGGCACTAAAAGG	0.398000													39	124					0	0	1	0	0
IL2RG	3561	broad.mit.edu	37	X	70331384	70331384	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:70331384C>T	ENST00000374202.2	-	1	97	c.6G>A	c.(4-6)ttG>ttA	p.L2L		NM_000206.2	NP_000197.1	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma	2					immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			breast(1)|endometrium(3)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	15	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	ATGATGGCTTCAACATGGCGC	0.552000									Severe Combined Immunodeficiency, X-linked				9	18					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51165497	51165497	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:51165497C>T	ENST00000293441.1	-	23	6229	c.6211G>A	c.(6211-6213)Ggg>Agg	p.G2071R	SHANK1_ENST00000391813.1_Missense_Mutation_p.G1458R|SHANK1_ENST00000391814.1_Missense_Mutation_p.G2079R|SYT3_ENST00000544769.1_Intron|SHANK1_ENST00000359082.3_Missense_Mutation_p.G2062R	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2071					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CGCGAGGCCCCTGACAAGGCT	0.692000													3	28					0	0	1	0	0
DAAM1	23002	broad.mit.edu	37	14	59798179	59798179	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr14:59798179C>T	ENST00000395125.1	+	13	1836	c.1813C>T	c.(1813-1815)Cag>Tag	p.Q605*	DAAM1_ENST00000351081.1_Nonsense_Mutation_p.Q605*|DAAM1_ENST00000360909.3_Nonsense_Mutation_p.Q605*	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	605	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AAGCATTCCTCAGCCCACAAA	0.532000													25	81					0	0	1	0	0
MIR513A1	574509	broad.mit.edu	37	X	146295085	146295085	+	RNA	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:146295085G>A	ENST00000385138.1	-	0	24					NR_030231.1																						ggcactgtacgctgaatggct	0.433000													3	11					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42486133	42486133	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:42486133C>A	ENST00000545399.1	-	9	1311	c.1158G>T	c.(1156-1158)caG>caT	p.Q386H	ATP1A3_ENST00000602133.1_Missense_Mutation_p.Q343H|ATP1A3_ENST00000302102.5_Missense_Mutation_p.Q373H|ATP1A3_ENST00000543770.1_Missense_Mutation_p.Q384H	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	373					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						TCATGCGGTTCTGAGTGAGGG	0.597000													8	177					0.000442599	0.000453054	1	1	0
ADAMTS2	9509	broad.mit.edu	37	5	178579179	178579179	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:178579179C>T	ENST00000251582.7	-	10	1694	c.1593G>A	c.(1591-1593)ggG>ggA	p.G531G	ADAMTS2_ENST00000274609.5_Silent_p.G531G	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	531	Disintegrin.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCAAGGGGGGCCCCTTCTTGG	0.592000													6	36					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126238269	126238269	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:126238269C>T	ENST00000394329.3	+	1	716	c.703C>T	c.(703-705)Cag>Tag	p.Q235*		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	235	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GGGCTACCTTCAGGTAAACGT	0.597000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	36					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6606437	6606437	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:6606437C>T	ENST00000433363.2	-	5	801	c.568G>A	c.(568-570)Ggc>Agc	p.G190S	SLC13A5_ENST00000381074.4_Missense_Mutation_p.G147S|SLC13A5_ENST00000293800.6_Missense_Mutation_p.G173S|SLC13A5_ENST00000573648.1_Missense_Mutation_p.G190S	NM_001284510.1|NM_177550.3	NP_001271439.1|NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	190						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						AGAGTGGGGCCTTCAAAAATC	0.627000													5	56					0	0	1	0	0
BCAS2	10286	broad.mit.edu	37	1	115118216	115118216	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:115118216G>T	ENST00000369541.3	-	4	461	c.414C>A	c.(412-414)taC>taA	p.Y138*	BCAS2_ENST00000485021.1_5'UTR	NM_005872.2	NP_005863.1	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	138					mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			biliary_tract(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)	13	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTACTCATTGTATACTTTCC	0.343000													19	49					1.56452e-12	1.68089e-12	1	1	0
BTG2	7832	broad.mit.edu	37	1	203276391	203276391	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:203276391C>T	ENST00000290551.4	+	2	373	c.302C>T	c.(301-303)aCc>aTc	p.T101I		NM_006763.2	NP_006754.1	P78543	BTG2_HUMAN	BTG family, member 2	101					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(75;0.203)			AGCGAGCTGACCCTGTGGGTG	0.642000													6	43					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29141694	29141694	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr6:29141694G>A	ENST00000377167.2	+	1	384	c.282G>A	c.(280-282)tcG>tcA	p.S94S		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						AGACCATCTCGTATGCTGGTT	0.473000													9	184					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24873919	24873919	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:24873919C>G	ENST00000396432.2	-	26	5785	c.5299G>C	c.(5299-5301)Gat>Cat	p.D1767H		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1766	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TTTAACCGATCTGCTATTTTC	0.463000													19	86					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108488251	108488251	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:108488251G>A	ENST00000408999.3	+	20	3868	c.3791G>A	c.(3790-3792)aGt>aAt	p.S1264N	RGPD4_ENST00000354986.4_Missense_Mutation_p.S1264N	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1264					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						GATAGTGTCAGTAGTAGCTCA	0.403000													122	253					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46859620	46859620	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:46859620G>T	ENST00000262738.3	-	2	4166	c.4167C>A	c.(4165-4167)tgC>tgA	p.C1389*	CELSR1_ENST00000395964.1_Nonsense_Mutation_p.C1389*	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1389	EGF-like 2; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGTCCTCGAAGCACTCGCAGG	0.647000													5	10					0.000602214	0.000611624	1	1	0
PAOX	196743	broad.mit.edu	37	10	135202547	135202547	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:135202547C>T	ENST00000480071.2	+	4	986	c.956C>T	c.(955-957)tCa>tTa	p.S319L	PAOX_ENST00000368535.2_3'UTR|PAOX_ENST00000278060.5_Silent_p.L403L|PAOX_ENST00000357296.3_Silent_p.L403L|PAOX_ENST00000368539.4_3'UTR	NM_207127.1	NP_997010.1	Q6QHF9	PAOX_HUMAN	polyamine oxidase (exo-N4-amino)	0					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|urinary_tract(2)	23		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		TTCTGTGTCTCACCCAAGTGC	0.502000													13	210					0	0	1	0	0
ZNF354B	117608	broad.mit.edu	37	5	178310335	178310335	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:178310335G>A	ENST00000322434.3	+	5	1108	c.882G>A	c.(880-882)gtG>gtA	p.V294V		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCATACTGTGGAGAAATGCT	0.378000													31	81					0	0	1	0	0
HSD17B13	345275	broad.mit.edu	37	4	88226451	88226451	+	Silent	SNP	A	A	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:88226451A>T	ENST00000328546.4	-	7	886	c.822T>A	c.(820-822)ccT>ccA	p.P274P	HSD17B13_ENST00000302219.6_Silent_p.P238P	NM_178135.3	NP_835236.2	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	274						extracellular region	binding|oxidoreductase activity			endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	8		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		AGGCGCGTTCAGGAAGAAACC	0.333000													8	24					0	0	1	0	0
SFTA3	253970	broad.mit.edu	37	14	36946212	36946212	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr14:36946212C>T	ENST00000518529.2	-	3	900	c.225G>A	c.(223-225)acG>acA	p.T75T	RP11-896J10.3_ENST00000521945.1_RNA|SFTA3_ENST00000518987.1_Intron	NM_001101341.1	NP_001094811.1	P0C7M3	SFTA3_HUMAN	surfactant associated 3	75										breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7						GTGACAGCGTCGTGGGATGCA	0.532000													8	111					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70903954	70903954	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:70903954C>T	ENST00000264436.4	-	13	2011	c.1567G>A	c.(1567-1569)Gtc>Atc	p.V523I	ADD2_ENST00000407644.2_Missense_Mutation_p.V523I|ADD2_ENST00000413157.2_Missense_Mutation_p.V523I|ADD2_ENST00000355733.3_Missense_Mutation_p.V523I|ADD2_ENST00000430656.1_Missense_Mutation_p.V539I	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)						actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						TCGGCAATGACGCTCGCCAGG	0.602000													12	53					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25320984	25320984	+	RNA	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr15:25320984C>T	ENST00000549804.2	+	0	1080																											TTGGCATGGTCTCCTTCAGGC	0.473000													6	28					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131640400	131640400	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:131640400G>A	ENST00000368648.3	-	13	1397	c.1325C>T	c.(1324-1326)aCg>aTg	p.T442M	EBF3_ENST00000355311.5_Missense_Mutation_p.T451M	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	451					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding	p.T442M(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GGCTTGTGACGTCTCTGACAC	0.597000													23	73					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155774915	155774915	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:155774915G>A	ENST00000437809.1	-	11	1592	c.1470C>T	c.(1468-1470)ctC>ctT	p.L490L	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000361040.5_Silent_p.L490L|GON4L_ENST00000368331.1_Silent_p.L490L|GON4L_ENST00000271883.5_Silent_p.L490L	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	490					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GAAATGCAATGAGACTGTCAT	0.458000													28	56					0	0	1	0	0
TSC1	7248	broad.mit.edu	37	9	135802692	135802692	+	Splice_Site	SNP	C	C	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr9:135802692C>A	ENST00000298552.3	-	4	328		c.e4-1		TSC1_ENST00000545250.1_Splice_Site|TSC1_ENST00000475903.1_Splice_Site|TSC1_ENST00000403810.1_Splice_Site|TSC1_ENST00000440111.2_Splice_Site	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1						activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding			NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GGGCCACGGTCTAAATCAAGA	0.428000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				9	12					0.0477658	0.0477658	1	1	0
MCM2	4171	broad.mit.edu	37	3	127325534	127325534	+	Silent	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:127325534C>G	ENST00000265056.7	+	6	1219	c.975C>G	c.(973-975)gtC>gtG	p.V325V		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	325					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						TCAGCATGGTCAAGTACAACT	0.612000													26	79					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	100200436	100200436	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:100200436C>T	ENST00000547776.2	-	4	414	c.415G>A	c.(415-417)Gga>Aga	p.G139R	ANKS1B_ENST00000329257.7_Missense_Mutation_p.G139R|ANKS1B_ENST00000547010.1_Intron	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	139						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TCTGAGTGTCCATATTGAGCT	0.398000													11	35					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121107201	121107201	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:121107201C>T	ENST00000295228.3	+	2	1021	c.975C>T	c.(973-975)acC>acT	p.T325T		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	325					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				TAGCACCCACCGGCTACTACG	0.617000													26	74					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110709723	110709723	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:110709723G>A	ENST00000331565.4	+	2	657	c.172G>A	c.(172-174)Gag>Aag	p.E58K	RP5-1028L10.1_ENST00000443008.1_RNA|RP5-1028L10.1_ENST00000430098.1_RNA|RP5-1028L10.1_ENST00000418579.1_RNA	NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	58					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		GCTGGATGCAGAGGACCGGCC	0.612000													5	15					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46859881	46859881	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:46859881G>A	ENST00000262738.3	-	2	3905	c.3906C>T	c.(3904-3906)ttC>ttT	p.F1302F	CELSR1_ENST00000395964.1_Silent_p.F1302F	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1302					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TGTTGTCGTCGAAGGGCAGCA	0.637000													10	36					0	0	1	0	0
ACAP1	9744	broad.mit.edu	37	17	7253548	7253548	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:7253548C>G	ENST00000158762.3	+	20	2270	c.2064C>G	c.(2062-2064)atC>atG	p.I688M		NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	688	Required for interaction with GULP1.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						ACGCTGACATCGTCACCCTGT	0.672000													14	37					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53348844	53348844	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr16:53348844A>G	ENST00000566029.1	+	36	7633	c.7424A>G	c.(7423-7425)aAt>aGt	p.N2475S	CHD9_ENST00000398510.3_Missense_Mutation_p.N2491S|CHD9_ENST00000564845.1_Missense_Mutation_p.N2475S|CHD9_ENST00000447540.1_Missense_Mutation_p.N2476S			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2491	Binds A/T-rich DNA.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				CCAGTTATTAATCTTAAAGAT	0.428000													19	54					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230450646	230450646	+	Missense_Mutation	SNP	T	T	A	rs72987941	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:230450646T>A	ENST00000341772.4	-	4	909	c.775A>T	c.(775-777)Acc>Tcc	p.T259S	DNER_ENST00000482831.1_5'UTR	NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	259					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity	p.T259P(1)		NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TGAAGGGGGGTCACACTTCGT	0.517000													4	59					0	0	1	0	0
RTP3	83597	broad.mit.edu	37	3	46542025	46542025	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:46542025C>G	ENST00000296142.3	+	2	907	c.335C>G	c.(334-336)tCa>tGa	p.S112*		NM_031440.1	NP_113628.1	Q9BQQ7	RTP3_HUMAN	receptor (chemosensory) transporter protein 3	112					detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			endometrium(1)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		GAGAACATCTCAAGGATCCTG	0.458000													39	87					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145116147	145116148	+	RNA	INS	-	-	A	rs138980379		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:145116147_145116148insA	ENST00000453618.1	+	0	1233_1234							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										AGTAGATTGTTATTTCGTTTTT	0.416													3	6	---	---	---	---					
ELF3	1999	broad.mit.edu	37	1	201983027	201983028	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:201983027_201983028insA	ENST00000359651.3	+	7	4068_4069	c.876_877insA	c.(877-879)atgfs	p.M293fs	RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367283.3_Frame_Shift_Ins_p.M293fs|ELF3_ENST00000367284.5_Frame_Shift_Ins_p.M293fs			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	293					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						ACGAGGGCCTCATGAAGTGGGA	0.574													7	20	---	---	---	---					
MTR	4548	broad.mit.edu	37	1	237024474	237024474	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:237024474delA	ENST00000366577.5	+	20	2487	c.2093delA	c.(2092-2094)caafs	p.Q698fs	MTR_ENST00000535889.1_Intron	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	698	B12-binding N-terminal.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AGGTTAAACCAAAAAAAATAT	0.308													7	132	---	---	---	---					
TCTA	6988	broad.mit.edu	37	3	49450045	49450047	+	In_Frame_Del	DEL	TAC	TAC	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:49450045_49450047delTAC	ENST00000273590.3	+	1	407_409	c.186_188delTAC	c.(184-189)aataca>aaa	p.62_63NT>K	RHOA_ENST00000265538.3_Intron|TCTA_ENST00000493381.1_3'UTR	NM_022171.2	NP_071503.1	P57738	TCTA_HUMAN	T-cell leukemia translocation altered	62						integral to membrane				large_intestine(4)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCTACGGGAATACAGTGACCGGG	0.635													30	84	---	---	---	---					
AC006988.1	0	broad.mit.edu	37	7	88269890	88269891	+	RNA	INS	-	-	T	rs113056340		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr7:88269890_88269891insT	ENST00000390184.1	+	0	56_57																											AGAAGGAGCACTTTTTTTTTTT	0.317													3	5	---	---	---	---					
C9orf41	138199	broad.mit.edu	37	9	77642981	77642983	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr9:77642981_77642983delCTC	ENST00000376834.3	-	1	327_329	c.175_177delGAG	c.(175-177)gagdel	p.E59del	C9orf41_ENST00000376837.3_In_Frame_Del_p.E59del|C9orf41_ENST00000376830.3_In_Frame_Del_p.E59del	NM_152420.1	NP_689633.1	Q8N4J0	CI041_HUMAN	chromosome 9 open reading frame 41	59										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|urinary_tract(2)	17						GCTCAAGCCTCTCCTCCTCCTCC	0.695													2	4	---	---	---	---					
SPTAN1	6709	broad.mit.edu	37	9	131388682	131388682	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr9:131388682delT	ENST00000358161.5	+	49	6405	c.6292delT	c.(6292-6294)ttcfs	p.F2098fs	SPTAN1_ENST00000372731.4_Frame_Shift_Del_p.F2093fs|SPTAN1_ENST00000372739.3_Frame_Shift_Del_p.F2098fs			Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2093					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GGAGGACCTCTTCCTGACCTT	0.582													38	90	---	---	---	---					
ZWILCH	55055	broad.mit.edu	37	15	66820228	66820229	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr15:66820228_66820229insA	ENST00000307897.5	+	10	1327_1328	c.947_948insA	c.(946-951)acaaaafs	p.TK316fs	ZWILCH_ENST00000535141.2_Frame_Shift_Ins_p.TK202fs|ZWILCH_ENST00000565627.1_Frame_Shift_Ins_p.TK202fs|ZWILCH_ENST00000446801.2_Frame_Shift_Ins_p.TK202fs	NM_017975.3	NP_060445.3	Q9H900	ZWILC_HUMAN	zwilch kinetochore protein	316					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(1)|lung(6)|ovary(1)	18						GGTGATTCTACAAAAAAAGACA	0.317													26	46	---	---	---	---					
TMEM102	284114	broad.mit.edu	37	17	7340636	7340636	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:7340636delG	ENST00000323206.1	+	3	1611	c.1338delG	c.(1336-1338)gagfs	p.E446fs	RP11-104H15.7_ENST00000575310.1_RNA|TMEM102_ENST00000396568.1_Frame_Shift_Del_p.E446fs|RP11-104H15.9_ENST00000570444.1_RNA	NM_178518.2	NP_848613.1	Q8N9M5	TM102_HUMAN	transmembrane protein 102	446					regulation of apoptosis|response to cytokine stimulus|signal transduction	cell surface|integral to membrane|intracellular	protein binding			kidney(1)|lung(3)|skin(1)	5		Prostate(122;0.173)				GAGTGCTCGAGGCCGGGACGT	0.697													2	4	---	---	---	---					
AC015922.5	0	broad.mit.edu	37	17	15737072	15737073	+	RNA	INS	-	-	TTTA	rs71838018		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:15737072_15737073insTTTA	ENST00000584636.1	+	0	316																											CTCTATCCTGCTTTATCTTGGA	0.460													2	4	---	---	---	---					
SF3A1	10291	broad.mit.edu	37	22	30742328	30742330	+	In_Frame_Del	DEL	CTG	CTG	-	rs141985009	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:30742328_30742330delCTG	ENST00000215793.8	-	3	518_520	c.364_366delCAG	c.(364-366)cagdel	p.Q122del	SF3A1_ENST00000439242.1_Intron	NM_005877.4	NP_005868.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa		Poly-Gln.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						GCTGGGTGGTCTGCTGCTGCTGC	0.606													8	97	---	---	---	---					
STAG2	10735	broad.mit.edu	37	X	123227957	123227974	+	In_Frame_Del	DEL	ATGAGGGAATGGATTTTG	ATGAGGGAATGGATTTTG	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:123227957_123227974delATGAGGGAATGGATTTTG	ENST00000371160.1	+	32	3847_3864	c.3557_3574delATGAGGGAATGGATTTTG	c.(3556-3576)aatgagggaatggattttgac>aac	p.EGMDFD1187del	STAG2_ENST00000371145.3_In_Frame_Del_p.EGMDFD1224del|STAG2_ENST00000354548.5_In_Frame_Del_p.EGMDFD1118del|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000218089.9_In_Frame_Del_p.EGMDFD1224del|STAG2_ENST00000371157.3_In_Frame_Del_p.EGMDFD1187del|STAG2_ENST00000371144.3_In_Frame_Del_p.EGMDFD1187del	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	1187					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						GAGGATCTTAATGAGGGAATGGATTTTGACACCATGGA	0.353													10	42	---	---	---	---					
