Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PKD1L1	168507	broad.mit.edu	37	7	47930253	47930253	+	Silent	SNP	T	T	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:47930253T>C	ENST00000289672.2	-	16	2612	c.2562A>G	c.(2560-2562)caA>caG	p.Q854Q		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	854	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						CACTGAGCCATTGTGCCTCAA	0.602000													9	41					0	0	1	0	0
SLC38A2	54407	broad.mit.edu	37	12	46765027	46765027	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:46765027C>T	ENST00000256689.5	-	2	494	c.50G>A	c.(49-51)aGc>aAc	p.S17N	SLC38A2_ENST00000547252.1_5'UTR	NM_018976.4	NP_061849.2	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	17	Regulates protein turnover upon amino acid deprivation (By similarity).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	18	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		GTAGCTGCTGCTGTCTTCATC	0.512000													33	121					0	0	1	0	0
KLC3	147700	broad.mit.edu	37	19	45854218	45854218	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:45854218G>C	ENST00000470402.1	+	11	1528	c.1428G>C	c.(1426-1428)aaG>aaC	p.K476N	KLC3_ENST00000585434.1_Missense_Mutation_p.K461N|KLC3_ENST00000391946.2_Missense_Mutation_p.K462N|ERCC2_ENST00000391945.4_3'UTR			Q6P597	KLC3_HUMAN	kinesin light chain 3	462						cytoplasm|kinesin complex|microtubule	microtubule motor activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	8		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GCAGAATGAAGAGAGCCATGT	0.552000													9	94					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72964852	72964852	+	Missense_Mutation	SNP	G	G	A	rs147715599		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:72964852G>A	ENST00000262209.4	-	14	2000	c.1793C>T	c.(1792-1794)aCg>aTg	p.T598M	RP11-383H13.1_ENST00000457356.4_3'UTR|RP11-383H13.1_ENST00000537896.1_3'UTR|RP11-383H13.1_ENST00000524152.1_3'UTR	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	598						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	CCTGATGATCGTAAGAACAAC	0.448000													24	72					0	0	1	0	0
TDGF1	6997	broad.mit.edu	37	3	46621463	46621463	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:46621463G>C	ENST00000296145.5	+	5	1094	c.361G>C	c.(361-363)Gac>Cac	p.D121H	LRRC2_ENST00000296144.3_5'UTR|TDGF1_ENST00000542931.1_Missense_Mutation_p.D105H	NM_003212.3	NP_003203.1	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	121					activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity			cervix(2)|endometrium(1)|kidney(1)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		TGTGCCCCATGACACCTGGCT	0.557000													12	49					0	0	1	0	0
OR14C36	127066	broad.mit.edu	37	1	248512486	248512486	+	Missense_Mutation	SNP	G	G	C	rs142744958		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:248512486G>C	ENST00000317861.1	+	1	410	c.410G>C	c.(409-411)cGa>cCa	p.R137P		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R137Q(1)		central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						GTGAACTCTCGAATCTGCATC	0.512000													12	102					0	0	1	0	0
CXCR2P1	3580	broad.mit.edu	37	2	218925149	218925149	+	RNA	SNP	G	G	A	rs6758271	by1000genomes	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:218925149G>A	ENST00000439871.1	-	0	1231					NR_002712.1																						TGATCAAGCCGTGTATGGCTA	0.502000													4	56					0	0	1	0	0
ELP3	55140	broad.mit.edu	37	8	27954743	27954743	+	Silent	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:27954743C>T	ENST00000256398.8	+	2	404	c.27C>T	c.(25-27)ctC>ctT	p.L9L	ELP3_ENST00000537665.1_Intron|ELP3_ENST00000523760.1_3'UTR|ELP3_ENST00000524103.1_Intron|ELP3_ENST00000521015.1_5'UTR|ELP3_ENST00000380353.4_5'UTR|ELP3_ENST00000542181.1_5'UTR	NM_001284220.1|NM_001284226.1|NM_018091.5	NP_001271149.1|NP_001271155.1|NP_060561.3	Q9H9T3	ELP3_HUMAN	elongator acetyltransferase complex subunit 3	9					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding			kidney(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		CAGGAGATCTCAGCCCTGCTG	0.373000													6	87					0	0	1	0	0
TRIM49C	642612	broad.mit.edu	37	11	89774454	89774454	+	Silent	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:89774454G>A	ENST00000448984.1	+	8	1424	c.1095G>A	c.(1093-1095)aaG>aaA	p.K365K	TRIM49C_ENST00000432771.1_Intron	NM_001195234.1	NP_001182163.1	P0CI26	T49L2_HUMAN	tripartite motif containing 49C	365	B30.2/SPRY.					intracellular	zinc ion binding			endometrium(3)|kidney(1)|lung(4)	8						GGAAGGAGAAGAATCAGAATG	0.443000													18	68					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71220684	71220684	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr16:71220684C>A	ENST00000393567.2	-	2	265	c.115G>T	c.(115-117)Gaa>Taa	p.E39*	HYDIN_ENST00000538248.1_Nonsense_Mutation_p.E66*|HYDIN_ENST00000448089.2_Nonsense_Mutation_p.E39*|HYDIN_ENST00000448691.1_Nonsense_Mutation_p.E39*|HYDIN_ENST00000288168.10_Nonsense_Mutation_p.E56*|HYDIN_ENST00000393550.2_Nonsense_Mutation_p.E39*|HYDIN_ENST00000541601.1_Nonsense_Mutation_p.E56*|HYDIN_ENST00000321489.5_Nonsense_Mutation_p.E39*	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	39										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				ACTTCTTCTTCTGTAACCACC	0.413000													12	65					1.08611e-07	1.16489e-07	1	1	0
UGT8	7368	broad.mit.edu	37	4	115544466	115544466	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:115544466G>A	ENST00000310836.6	+	2	952	c.430G>A	c.(430-432)Gga>Aga	p.G144R	UGT8_ENST00000394511.3_Missense_Mutation_p.G144R	NM_001128174.1	NP_001121646	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	144					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		TGATATGTGTGGATTTGTGAT	0.448000													49	97					0	0	1	0	0
EMILIN2	84034	broad.mit.edu	37	18	2892374	2892374	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:2892374C>T	ENST00000254528.3	+	4	2408	c.2249C>T	c.(2248-2250)tCg>tTg	p.S750L		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	750					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		ACGCTCAGGTCGCATTCCAGA	0.483000													21	165					0	0	1	0	0
ZNF706	51123	broad.mit.edu	37	8	102213947	102213947	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:102213947A>T	ENST00000520347.1	-	2	2979	c.23T>A	c.(22-24)aTt>aAt	p.I8N	ZNF706_ENST00000518336.1_Missense_Mutation_p.I8N|ZNF706_ENST00000519882.1_Missense_Mutation_p.I8N|ZNF706_ENST00000311212.4_Missense_Mutation_p.I8N|ZNF706_ENST00000521272.1_Missense_Mutation_p.I8N|ZNF706_ENST00000520984.1_Missense_Mutation_p.I8N|ZNF706_ENST00000519744.1_Missense_Mutation_p.I8N|ZNF706_ENST00000517844.1_Missense_Mutation_p.I8N			Q9Y5V0	ZN706_HUMAN	zinc finger protein 706	8						intracellular	zinc ion binding			large_intestine(1)|ovary(2)	3	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			CTGAGACTGAATTTTCTGCTG	0.393000													8	36					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129680811	129680811	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:129680811G>T	ENST00000358303.4	-	3	473	c.389C>A	c.(388-390)cCa>cAa	p.P130Q	ZC3HC1_ENST00000311873.5_Missense_Mutation_p.P109Q|ZC3HC1_ENST00000481503.1_Missense_Mutation_p.P130Q|ZC3HC1_ENST00000360708.5_Missense_Mutation_p.P130Q	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	130					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					GTCAAAAGCTGGTTGTAAACT	0.418000													32	129					8.88839e-20	1.01652e-19	1	1	0
DCP2	167227	broad.mit.edu	37	5	112327847	112327847	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:112327847C>G	ENST00000389063.2	+	3	433	c.235C>G	c.(235-237)Caa>Gaa	p.Q79E	DCP2_ENST00000515408.1_Missense_Mutation_p.Q79E|DCP2_ENST00000543319.1_Intron	NM_152624.5	NP_689837	Q8IU60	DCP2_HUMAN	decapping mRNA 2	79					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|RNA binding			endometrium(3)|large_intestine(6)|lung(1)	10		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		TTTGCTGCCTCAAGGTGAAGA	0.353000													19	82					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64168367	64168367	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:64168367A>T	ENST00000395391.1	+	4	3060	c.1685A>T	c.(1684-1686)aAc>aTc	p.N562I	ZNF107_ENST00000344930.3_Missense_Mutation_p.N562I|ZNF107_ENST00000423627.1_Missense_Mutation_p.N562I			Q9UII5	ZN107_HUMAN	zinc finger protein 107	562					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AAAGTTTTTAACCAGTCCTCA	0.348000													32	50					0	0	1	0	0
OTUD7A	161725	broad.mit.edu	37	15	31793915	31793915	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr15:31793915C>G	ENST00000382902.1	-	8	1241	c.1149G>C	c.(1147-1149)caG>caC	p.Q383H	OTUD7A_ENST00000307050.4_Missense_Mutation_p.Q376H			Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	376	Catalytic (By similarity).|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		GCTGGTCTCTCTGTTCCATGG	0.577000													9	57					0	0	1	0	0
ZNF35	7584	broad.mit.edu	37	3	44692740	44692740	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:44692740G>C	ENST00000396056.2	+	2	416	c.181G>C	c.(181-183)Gag>Cag	p.E61Q	RP11-944L7.4_ENST00000457331.1_RNA|ZNF35_ENST00000296092.3_Missense_Mutation_p.E61Q|ZNF35_ENST00000542250.1_5'UTR|ZNF35_ENST00000399560.2_Missense_Mutation_p.E61Q|ZNF35_ENST00000453164.1_Missense_Mutation_p.E61Q	NM_003420.3	NP_003411.3	P13682	ZNF35_HUMAN	zinc finger protein 35	61	Globular domain.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	12		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		TGGATCAGAAGAGGAAGAAAA	0.537000													5	38					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420612	55420612	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:55420612G>C	ENST00000242994.3	+	2	767	c.389G>C	c.(388-390)aGa>aCa	p.R130T		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	130	Helix-loop-helix motif.				amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						GAGACTCTTAGACTGGCCAGG	0.502000													16	67					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21183933	21183933	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:21183933C>T	ENST00000602326.1	-	23	3735	c.3152G>A	c.(3151-3153)cGg>cAg	p.R1051Q	EIF4G3_ENST00000400422.1_Missense_Mutation_p.R1045Q|EIF4G3_ENST00000264211.8_Missense_Mutation_p.R1045Q|EIF4G3_ENST00000374935.3_Missense_Mutation_p.R765Q|EIF4G3_ENST00000537738.1_Missense_Mutation_p.R535Q|EIF4G3_ENST00000536266.1_Missense_Mutation_p.R649Q|EIF4G3_ENST00000374937.3_Missense_Mutation_p.R1051Q	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	1045					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GTCCAGTACCCGACTGTTCTT	0.463000													101	247					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48623896	48623896	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:48623896G>C	ENST00000328333.8	-	26	3526	c.3419C>G	c.(3418-3420)aCa>aGa	p.T1140R	COL7A1_ENST00000454817.1_Missense_Mutation_p.T1140R	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1140	Nonhelical region (NC1).|VWFA 2.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCTGTGAGCTGTGACCACGGC	0.592000													67	95					0	0	1	0	0
EVC2	132884	broad.mit.edu	37	4	5570351	5570351	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:5570351G>A	ENST00000310917.2	-	20	3868	c.3137C>T	c.(3136-3138)tCg>tTg	p.S1046L	EVC2_ENST00000344408.5_Missense_Mutation_p.S1126L|EVC2_ENST00000344938.1_Missense_Mutation_p.S1126L	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	1126						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						CGCCAGGTACGATGCCAGTCT	0.577000													6	11					0	0	1	0	0
PELI1	57162	broad.mit.edu	37	2	64322381	64322381	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:64322381A>C	ENST00000358912.4	-	7	1154	c.712T>G	c.(712-714)Tta>Gta	p.L238V		NM_020651.3	NP_065702.2	Q96FA3	PELI1_HUMAN	pellino E3 ubiquitin protein ligase 1	238					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	19						CCATCTTGTAACTGATTGGTT	0.398000													25	43					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53012246	53012246	+	Silent	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:53012246G>A	ENST00000305748.3	-	1	97	c.63C>T	c.(61-63)tcC>tcT	p.S21S		NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	21	Gly-rich.|Head.					keratin filament	structural molecule activity	p.S21S(2)		NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		AGAGCACAGCGGAGCAGCCGC	0.642000													26	52					0	0	1	0	0
HYAL2	8692	broad.mit.edu	37	3	50357493	50357493	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:50357493C>T	ENST00000447092.1	-	1	2720	c.428G>A	c.(427-429)cGc>cAc	p.R143H	HYAL2_ENST00000442581.1_Missense_Mutation_p.R143H|HYAL2_ENST00000357750.4_Missense_Mutation_p.R143H|HYAL2_ENST00000395139.3_Missense_Mutation_p.R143H|TUSC2_ENST00000462137.1_5'UTR			Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2	143						anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			breast(1)|endometrium(2)|kidney(1)|ovary(1)|prostate(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	CTGCCAGTTGCGCACCCACAC	0.592000													21	98					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173961175	173961175	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:173961175C>T	ENST00000506823.1	+	13	2387	c.1730C>T	c.(1729-1731)tCt>tTt	p.S577F	GALNTL6_ENST00000508122.1_Missense_Mutation_p.S560F	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	577	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						GACCCTCTCTCTGAGACTCAG	0.428000													16	71					0	0	1	0	0
FHL2	2274	broad.mit.edu	37	2	105979821	105979821	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:105979821G>A	ENST00000336660.5	-	4	554	c.434C>T	c.(433-435)gCg>gTg	p.A145V	FHL2_ENST00000358129.4_Silent_p.R203R|FHL2_ENST00000393353.3_Silent_p.R203R|FHL2_ENST00000344213.4_Silent_p.R313R|FHL2_ENST00000322142.8_Silent_p.R203R|FHL2_ENST00000409177.1_Silent_p.R319R|FHL2_ENST00000393352.3_Silent_p.R203R|FHL2_ENST00000409807.1_Silent_p.R203R|AC012360.6_ENST00000457290.2_RNA|FHL2_ENST00000408995.1_Silent_p.R203R			Q14192	FHL2_HUMAN	four and a half LIM domains 2	0	LIM zinc-binding 2.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent	actin cytoskeleton|focal adhesion|nucleus	androgen receptor binding|identical protein binding|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	9						CAAAGTCATCGCGAGCTGTGA	0.612000													4	13					0	0	1	0	0
EIF4A3	9775	broad.mit.edu	37	17	78113852	78113852	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:78113852C>G	ENST00000269349.3	-	5	681	c.460G>C	c.(460-462)Gat>Cat	p.D154H		NM_014740.3	NP_055555.1	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A3	154	Helicase ATP-binding.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			TGTCCGTAATCCAGCTTCCTG	0.512000													4	55					0	0	1	0	0
SLC9B1	150159	broad.mit.edu	37	4	103867833	103867833	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:103867833T>C	ENST00000296422.7	-	5	637	c.496A>G	c.(496-498)Ata>Gta	p.I166V	SLC9B1_ENST00000394789.3_Missense_Mutation_p.I166V	NM_139173.3	NP_631912	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	166						integral to membrane	solute:hydrogen antiporter activity										CCAGCTCTTATTAGAATAATG	0.363000													45	41					0	0	1	0	0
PLXNB3	5365	broad.mit.edu	37	X	153043091	153043091	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chrX:153043091G>A	ENST00000538966.1	+	32	5549	c.5278G>A	c.(5278-5280)Gag>Aag	p.E1760K	PLXNB3_ENST00000485980.1_3'UTR|PLXNB3_ENST00000538776.1_Missense_Mutation_p.E1390K|SRPK3_ENST00000489426.1_5'UTR|PLXNB3_ENST00000361971.5_Missense_Mutation_p.E1737K	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	1737					axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TGAGCTAGCAGAGAAGCACGG	0.582000													6	100					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145113243	145113243	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:145113243G>A	ENST00000426825.1	-	7	929	c.848C>T	c.(847-849)tCc>tTc	p.S283F	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	283							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CACAGCACTGGAGCCGCTGAA	0.687000													4	10					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139393627	139393627	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:139393627C>T	ENST00000277541.6	-	32	6094	c.6019G>A	c.(6019-6021)Gtg>Atg	p.V2007M		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	2007					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ATGCCCTCCACGGCCAGGCGG	0.657000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			18	27					0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23393862	23393862	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr14:23393862G>C	ENST00000324366.8	-	9	1219	c.996C>G	c.(994-996)atC>atG	p.I332M	PRMT5-AS1_ENST00000587245.2_RNA|PRMT5_ENST00000216350.8_Missense_Mutation_p.I271M|PRMT5-AS1_ENST00000590290.1_RNA|PRMT5-AS1_ENST00000595662.1_RNA|PRMT5_ENST00000538452.1_Missense_Mutation_p.I226M|PRMT5-AS1_ENST00000599580.2_RNA|PRMT5_ENST00000397440.4_Missense_Mutation_p.I161M|PRMT5_ENST00000397441.2_Missense_Mutation_p.I315M|PRMT5_ENST00000553897.1_Missense_Mutation_p.I288M	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	332					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		GAGAGTATTTGATGGGGTCCT	0.478000													6	52					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6191265	6191265	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:6191265C>T	ENST00000530810.1	-	1	373	c.292G>A	c.(292-294)Gcc>Acc	p.A98T	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGACACAGGCATCAAAAGCA	0.517000													18	71					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129304863	129304863	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:129304863C>T	ENST00000393239.1	-	5	1961	c.1783G>A	c.(1783-1785)Gag>Aag	p.E595K	PLXND1_ENST00000324093.4_Missense_Mutation_p.E595K			Q9Y4D7	PLXD1_HUMAN	plexin D1	595					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CTGGGGCCCTCGCTGGCACTG	0.657000													24	94					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6243787	6243787	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:6243787C>T	ENST00000265978.4	-	6	1434	c.1076G>A	c.(1075-1077)cGg>cAg	p.R359Q	FAM160A2_ENST00000524416.1_Missense_Mutation_p.R359Q|FAM160A2_ENST00000449352.2_Missense_Mutation_p.R359Q	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	359					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TGAGATACTCCGTAGGAAAAG	0.527000													17	37					0	0	1	0	0
ALAS1	211	broad.mit.edu	37	3	52248035	52248035	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:52248035G>C	ENST00000394965.2	+	12	2122		c.e12-1		ALAS1_ENST00000310271.2_Splice_Site|ALAS1_ENST00000484952.1_Splice_Site|ALAS1_ENST00000469224.1_Splice_Site	NM_000688.5	NP_000679.1	P13196	HEM1_HUMAN	aminolevulinate, delta-, synthase 1						heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			endometrium(3)|kidney(3)|large_intestine(7)|liver(2)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TTTCTCCTCAGAGAATCTGCT	0.408000													11	46					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43778257	43778257	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:43778257C>A	ENST00000372476.3	+	12	1991	c.1912C>A	c.(1912-1914)Ctt>Att	p.L638I	TIE1_ENST00000433781.2_Missense_Mutation_p.L283I	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	638					mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGCACACGTGCTTCTGCCCCC	0.657000													24	29					2.44723e-14	2.76818e-14	1	1	0
PIP5K1A	8394	broad.mit.edu	37	1	151171506	151171506	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:151171506G>C	ENST00000409426.1	+	1	479	c.34G>C	c.(34-36)Gtc>Ctc	p.V12L	PIP5K1A_ENST00000441902.2_Missense_Mutation_p.V12L|PIP5K1A_ENST00000368888.4_Missense_Mutation_p.V12L|PIP5K1A_ENST00000368890.4_Missense_Mutation_p.V12L			Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	12					phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			breast(1)|central_nervous_system(1)|ovary(1)|skin(1)|stomach(1)	5	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			GTCGTCTTCGGTCGGTTTTTC	0.612000													44	342					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37622222	37622222	+	Silent	SNP	G	G	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:37622222G>T	ENST00000297153.7	-	6	1988	c.810C>A	c.(808-810)ctC>ctA	p.L270L	MDGA1_ENST00000505425.1_Silent_p.L270L|MDGA1_ENST00000434837.3_Silent_p.L270L			Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	270	Ig-like 3.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						GCAGCTGGGGGAGGGGATCAC	0.647000													22	41					7.45023e-12	8.20317e-12	1	1	0
NDUFB5	4711	broad.mit.edu	37	3	179322629	179322629	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:179322629G>T	ENST00000493866.1	+	1	51	c.26G>T	c.(25-27)cGg>cTg	p.R9L	NDUFB5_ENST00000259037.3_Missense_Mutation_p.R9L|NDUFB5_ENST00000472629.1_Missense_Mutation_p.R9L	NM_001199957.1	NP_001186886.1	O43674	NDUB5_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	9					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity	p.R9P(1)		endometrium(1)|lung(6)|skin(1)	8	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)		NADH(DB00157)	TTGTTGCGGCGGGTTTCGGTT	0.607000													9	37					0.00621372	0.00646351	1	1	0
ABCA1	19	broad.mit.edu	37	9	107580989	107580989	+	Silent	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:107580989G>A	ENST00000374736.3	-	23	3811	c.3417C>T	c.(3415-3417)ctC>ctT	p.L1139L		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	1139					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGCAGGAACTGAGGGAGGATT	0.537000													6	84					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56420230	56420230	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:56420230G>T	ENST00000370754.5	-	60	14955	c.14956C>A	c.(14956-14958)Ctg>Atg	p.L4986M	DST_ENST00000421834.2_Missense_Mutation_p.L2720M|DST_ENST00000361203.3_Missense_Mutation_p.L4806M|DST_ENST00000446842.2_Missense_Mutation_p.L4482M|DST_ENST00000370788.2_Missense_Mutation_p.L2720M|DST_ENST00000370769.4_Missense_Mutation_p.L4808M|DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Missense_Mutation_p.L2394M			Q03001	DYST_HUMAN	dystonin	4806					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCTTTAACCAGTGCTGACAAA	0.408000													33	70					4.11147e-13	4.60041e-13	1	1	0
RGS7	6000	broad.mit.edu	37	1	240966262	240966262	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:240966262G>A	ENST00000366565.1	-	16	1682	c.1301C>T	c.(1300-1302)tCa>tTa	p.S434L	RGS7_ENST00000446183.2_Missense_Mutation_p.S350L|RGS7_ENST00000407727.1_Missense_Mutation_p.S434L|RGS7_ENST00000331110.7_Missense_Mutation_p.S408L|RGS7_ENST00000348120.2_Missense_Mutation_p.S381L|RGS7_ENST00000366563.1_Missense_Mutation_p.S434L|RGS7_ENST00000401882.1_Missense_Mutation_p.S381L|RGS7_ENST00000366564.1_Missense_Mutation_p.S434L|RGS7_ENST00000366562.4_Missense_Mutation_p.S434L	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	434	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			ACGTGGGTATGAATCACTTTT	0.358000													23	94					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68255131	68255131	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr16:68255131C>T	ENST00000349223.5	+	10	3363	c.3139C>T	c.(3139-3141)Cag>Tag	p.Q1047*	NFATC3_ENST00000329524.4_Intron|RP11-96D1.5_ENST00000569088.1_RNA|NFATC3_ENST00000535127.2_Intron|NFATC3_ENST00000346183.3_Intron	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	0					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TGACTTGCTTCAGTTGAGACC	0.403000													21	61					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34663196	34663196	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:34663196G>A	ENST00000488417.1	+	2	811	c.691G>A	c.(691-693)Gac>Aac	p.D231N	C1orf94_ENST00000373374.3_Missense_Mutation_p.D41N	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	41							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				CATCCTAGGTGACTCCAACTT	0.542000													14	35					0	0	1	0	0
CCDC101	112869	broad.mit.edu	37	16	28602255	28602255	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr16:28602255G>A	ENST00000317058.3	+	9	951	c.764G>A	c.(763-765)cGg>cAg	p.R255Q		NM_138414.2	NP_612423.1	Q96ES7	SGF29_HUMAN	coiled-coil domain containing 101	255	SGF29 C-terminal.				establishment of protein localization to chromatin|histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|SAGA-type complex	methylated histone residue binding			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10						CCCCCACAGCGGGTAAAGCAG	0.617000													3	13					0	0	1	0	0
CXorf66	347487	broad.mit.edu	37	X	139038603	139038603	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chrX:139038603C>T	ENST00000370540.1	-	3	561	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K		NM_001013403.2	NP_001013421.1	Q5JRM2	CX066_HUMAN	chromosome X open reading frame 66	180						integral to membrane				breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|skin(1)|stomach(1)	26						TGTGCCTTTTCCAGGTGAGAT	0.413000													65	149					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19571845	19571845	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:19571845C>G	ENST00000507958.1	-	10	2086	c.1096G>C	c.(1096-1098)Gat>Cat	p.D366H	CDH18_ENST00000274170.4_Missense_Mutation_p.D366H|CDH18_ENST00000506372.1_Missense_Mutation_p.D366H|CDH18_ENST00000382275.1_Missense_Mutation_p.D366H|CDH18_ENST00000511273.1_Missense_Mutation_p.D366H|CDH18_ENST00000502796.1_Missense_Mutation_p.D366H			Q13634	CAD18_HUMAN	cadherin 18, type 2	366	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ATAGTAGCATCTTTAAAAGGA	0.403000													19	55					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56391242	56391242	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:56391242C>T	ENST00000370754.5	-	69	17952	c.17953G>A	c.(17953-17955)Gac>Aac	p.D5985N	DST_ENST00000421834.2_Missense_Mutation_p.D3719N|DST_ENST00000361203.3_Missense_Mutation_p.D5696N|DST_ENST00000340834.4_5'UTR|DST_ENST00000446842.2_Missense_Mutation_p.D5481N|DST_ENST00000370788.2_Missense_Mutation_p.D3610N|DST_ENST00000370769.4_Missense_Mutation_p.D5807N|DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Missense_Mutation_p.D3393N			Q03001	DYST_HUMAN	dystonin	5805					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CGCTCATTGTCCTCAGCTACC	0.493000													35	127					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7808955	7808955	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:7808955G>C	ENST00000380358.4	+	27	4333	c.4332G>C	c.(4330-4332)aaG>aaC	p.K1444N	CHD3_ENST00000330494.7_Missense_Mutation_p.K1385N|CHD3_ENST00000358181.4_Missense_Mutation_p.K1385N	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1385					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				GACAGTCAAAGAGGCAGCTCC	0.567000													6	16					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183087279	183087279	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:183087279G>C	ENST00000258341.4	+	11	2245	c.1988G>C	c.(1987-1989)aGa>aCa	p.R663T		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	663	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent	p.R663I(1)		NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TACAGTGAGAGAAGTAAGTTA	0.353000													11	41					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113149637	113149637	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:113149637T>C	ENST00000401783.2	-	42	10324	c.9988A>G	c.(9988-9990)Agt>Ggt	p.S3330G	SVEP1_ENST00000374469.1_Missense_Mutation_p.S3307G|SVEP1_ENST00000297826.5_Missense_Mutation_p.S1256G	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3330	Sushi 32.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CCTTCAAGACTGTAGCCTCTG	0.483000													19	50					0	0	1	0	0
MTF2	22823	broad.mit.edu	37	1	93581036	93581036	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:93581036G>A	ENST00000370298.4	+	6	782	c.493G>A	c.(493-495)Gca>Aca	p.A165T	MTF2_ENST00000370303.4_Missense_Mutation_p.A165T|MTF2_ENST00000471953.1_3'UTR|MTF2_ENST00000545708.1_Missense_Mutation_p.A63T|MTF2_ENST00000540243.1_Missense_Mutation_p.A63T	NM_001164392.1|NM_007358.3	NP_001157864.1|NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription factor 2	165						nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		GAGGGGTGGTGCACTTAAGAA	0.393000													11	33					0	0	1	0	0
ZNF419	79744	broad.mit.edu	37	19	58005153	58005153	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:58005153G>T	ENST00000424930.2	+	5	1460	c.1231G>T	c.(1231-1233)Gag>Tag	p.E411*	AC003005.4_ENST00000601674.1_Intron|ZNF419_ENST00000221735.7_Nonsense_Mutation_p.E410*|ZNF419_ENST00000347466.6_Nonsense_Mutation_p.E378*|ZNF419_ENST00000415379.2_Nonsense_Mutation_p.E364*|ZNF419_ENST00000442920.2_Nonsense_Mutation_p.E397*|ZNF419_ENST00000426954.2_Nonsense_Mutation_p.E398*|ZNF419_ENST00000354197.4_Splice_Site	NM_001098491.1|NM_024691.3	NP_001091961.1|NP_078967.3	Q96HQ0	ZN419_HUMAN	zinc finger protein 419	410					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		ATTCTTTAGAGAGAATTCCAC	0.418000													24	120					9.57634e-11	1.03785e-10	1	1	0
GRM2	2912	broad.mit.edu	37	3	51747292	51747292	+	Silent	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:51747292C>G	ENST00000395052.3	+	3	1488	c.1254C>G	c.(1252-1254)ctC>ctG	p.L418L	GRM2_ENST00000475478.1_Intron|GRM2_ENST00000442933.2_Silent_p.L418L	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	418					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GGCGCCGCCTCTACAAGGACT	0.587000													9	19					0	0	1	0	0
ADRA1A	148	broad.mit.edu	37	8	26628136	26628136	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:26628136C>T	ENST00000380573.3	-	3	1954	c.931G>A	c.(931-933)Gta>Ata	p.V311I	ADRA1A_ENST00000354550.4_Missense_Mutation_p.V311I|ADRA1A_ENST00000380582.3_Missense_Mutation_p.V311I|ADRA1A_ENST00000519229.1_Missense_Mutation_p.V311I|ADRA1A_ENST00000276393.4_Missense_Mutation_p.V311I|ADRA1A_ENST00000380581.2_Intron|ADRA1A_ENST00000380587.1_Intron|ADRA1A_ENST00000380586.1_Missense_Mutation_p.V311I			P35348	ADA1A_HUMAN	adrenoceptor alpha 1A	311					activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity	p.V311I(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|skin(1)	36		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	AGCCAAAATACTATTTTAAAA	0.393000													19	62					0	0	1	0	0
ZBTB22	9278	broad.mit.edu	37	6	33284496	33284496	+	Silent	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:33284496C>T	ENST00000431845.2	-	2	349	c.198G>A	c.(196-198)cgG>cgA	p.R66R	ZBTB22_ENST00000418724.1_Silent_p.R66R	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	66	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						CCCGGAACTCCCGGCCCTGCA	0.592000													48	70					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45905274	45905274	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr20:45905274C>G	ENST00000311275.7	-	11	1457	c.1204G>C	c.(1204-1206)Gac>Cac	p.D402H	ZMYND8_ENST00000458360.2_Missense_Mutation_p.D397H|ZMYND8_ENST00000360911.3_Missense_Mutation_p.D397H|ZMYND8_ENST00000396281.4_Missense_Mutation_p.D402H|ZMYND8_ENST00000446994.2_Missense_Mutation_p.D339H|ZMYND8_ENST00000461685.1_Missense_Mutation_p.D422H|ZMYND8_ENST00000540497.1_Missense_Mutation_p.D397H|ZMYND8_ENST00000536340.1_Missense_Mutation_p.D429H|ZMYND8_ENST00000471951.2_Missense_Mutation_p.D422H|ZMYND8_ENST00000352431.2_Missense_Mutation_p.D422H|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000355972.4_Missense_Mutation_p.D402H|ZMYND8_ENST00000372023.3_Missense_Mutation_p.D397H|ZMYND8_ENST00000262975.4_Missense_Mutation_p.D402H	NM_001281772.1|NM_001281778.1|NM_001281783.1	NP_001268701.1|NP_001268707.1|NP_001268712.1	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	402							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GCCGTCATGTCAAAGTTGAGC	0.582000													40	133					0	0	1	0	0
PLEKHA8	84725	broad.mit.edu	37	7	30094400	30094400	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:30094400C>G	ENST00000449726.1	+	8	1222	c.872C>G	c.(871-873)tCa>tGa	p.S291*	PLEKHA8_ENST00000258679.7_Nonsense_Mutation_p.S291*|PLEKHA8_ENST00000396259.1_Nonsense_Mutation_p.S291*|PLEKHA8_ENST00000396257.2_Nonsense_Mutation_p.S291*	NM_001197027.1	NP_001183956.1	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	291					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						CAGTCTGGATCAGACTCAAGT	0.388000													22	68					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848028	123848028	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:123848028G>A	ENST00000531945.1	-	1	460	c.371C>T	c.(370-372)aCt>aTt	p.T124I		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GAAGCACTCAGTGCTGGCCAG	0.542000													8	23					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102550835	102550835	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr14:102550835C>G	ENST00000334701.7	-	7	1695	c.1414G>C	c.(1414-1416)Gat>Cat	p.D472H	HSP90AA1_ENST00000441629.2_Missense_Mutation_p.D171H|HSP90AA1_ENST00000216281.8_Missense_Mutation_p.D350H	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	350					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	TCAAACAGATCAAAAGGAGCA	0.373000													15	61					0	0	1	0	0
BRPF3	27154	broad.mit.edu	37	6	36168155	36168155	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:36168155C>T	ENST00000357641.6	+	2	309	c.56C>T	c.(55-57)tCc>tTc	p.S19F	BRPF3_ENST00000534400.1_Missense_Mutation_p.S19F|BRPF3_ENST00000339717.7_Missense_Mutation_p.S19F|BRPF3_ENST00000543502.1_Missense_Mutation_p.S19F|BRPF3_ENST00000534694.1_Missense_Mutation_p.S19F|BRPF3_ENST00000443324.2_Missense_Mutation_p.S19F	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	19					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						CGTTCCCCGTCCCCCTACAGT	0.627000													6	75					0	0	1	0	0
TBC1D3P5	440419	broad.mit.edu	37	17	25753587	25753587	+	RNA	SNP	C	C	T	rs1993829	by1000genomes	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:25753587C>T	ENST00000586223.1	+	0	1595					NR_033892.1																						TTCAGAGGAGCAAGTCCACGT	0.552000													5	50					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156844786	156844786	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:156844786A>T	ENST00000368196.3	+	10	1442	c.1322A>T	c.(1321-1323)aAg>aTg	p.K441M	NTRK1_ENST00000358660.3_Missense_Mutation_p.K441M|NTRK1_ENST00000524377.1_Missense_Mutation_p.K447M|NTRK1_ENST00000392302.2_Missense_Mutation_p.K411M	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	447					activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CGGAGAAACAAGTTTGGGATC	0.577000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			36	155					0	0	1	0	0
IGHV4-28	28400	broad.mit.edu	37	14	106780963	106780963	+	RNA	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr14:106780963C>G	ENST00000390612.2	-	0	54																											CACAGGAGGTCCAGGACTCTC	0.498000													5	47					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150171609	150171609	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:150171609G>A	ENST00000307271.3	+	4	1766	c.1192G>A	c.(1192-1194)Gcc>Acc	p.A398T		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	398						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CAGATATAGTGCCTTCAACTA	0.443000													24	110					0	0	1	0	0
SERPINA12	145264	broad.mit.edu	37	14	94964104	94964104	+	Missense_Mutation	SNP	G	G	C	rs61757459	byFrequency	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr14:94964104G>C	ENST00000341228.2	-	3	1426	c.631C>G	c.(631-633)Cga>Gga	p.R211G	SERPINA12_ENST00000556881.1_Missense_Mutation_p.R211G	NM_173850.2	NP_776249.1	Q8IW75	SPA12_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	211					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33				COAD - Colon adenocarcinoma(157;0.235)		GCCTTACCTCGAAAGAAAATA	0.408000													19	64					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000595295.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													5	23					0.184627	0.184627	1	1	0
PSG1	5669	broad.mit.edu	37	19	43376193	43376193	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:43376193C>G	ENST00000244296.2	-	3	572	c.435G>C	c.(433-435)gaG>gaC	p.E145D	PSG1_ENST00000595356.1_Missense_Mutation_p.E145D|PSG1_ENST00000312439.6_Missense_Mutation_p.E145D|PSG1_ENST00000595124.1_Intron|PSG1_ENST00000436291.2_Missense_Mutation_p.E145D|PSG1_ENST00000403380.3_Intron	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				GCTTAGGAGTCTCCACTGTGC	0.522000													28	330					0	0	1	0	0
F2RL1	2150	broad.mit.edu	37	5	76128611	76128611	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:76128611C>G	ENST00000296677.4	+	2	385	c.179C>G	c.(178-180)tCt>tGt	p.S60C		NM_005242.4	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	60					blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	13		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		ACAGTCTTTTCTGTGGATGAG	0.438000													32	71					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15366963	15366963	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:15366963C>A	ENST00000263377.2	-	9	1884	c.1663G>T	c.(1663-1665)Gag>Tag	p.E555*	BRD4_ENST00000360016.5_Nonsense_Mutation_p.E555*|BRD4_ENST00000602230.1_5'UTR|BRD4_ENST00000371835.4_Nonsense_Mutation_p.E555*	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	555	Lys-rich.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			tccacttcctctttccttttg	0.433000			T	C15orf55	lethal midline carcinoma of young people								7	41					0.0293803	0.0301076	1	1	0
PIGF	5281	broad.mit.edu	37	2	46842192	46842192	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:46842192C>G	ENST00000281382.6	-	2	282	c.112G>C	c.(112-114)Gaa>Caa	p.E38Q	PIGF_ENST00000495933.1_5'UTR|PIGF_ENST00000306465.4_Missense_Mutation_p.E38Q	NM_002643.3	NP_002634.1	Q07326	PIGF_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class F	38					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	ethanolaminephosphotransferase activity			breast(1)|endometrium(1)|lung(1)|stomach(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			AAGTGTGTTTCCAATATTGAG	0.348000													20	118					0	0	1	0	0
RETSAT	54884	broad.mit.edu	37	2	85570773	85570773	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:85570773A>T	ENST00000295802.4	-	10	1794	c.1682T>A	c.(1681-1683)cTc>cAc	p.L561H	RETSAT_ENST00000457495.2_Missense_Mutation_p.L500H|RETSAT_ENST00000263854.6_3'UTR	NM_017750.3	NP_060220.3	Q6NUM9	RETST_HUMAN	retinol saturase (all-trans-retinol 13,14-reductase)	561					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	30					Vitamin A(DB00162)	TGTCAGATAGAGGTTGGGGAT	0.647000													21	36					0	0	1	0	0
KCNN2	3781	broad.mit.edu	37	5	113698511	113698511	+	Silent	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:113698511G>A	ENST00000512097.3	+	2	1057	c.39G>A	c.(37-39)ccG>ccA	p.P13P	KCNN2_ENST00000264773.3_Silent_p.P13P			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	13						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TCATGCGGCCGCTCAGCAACT	0.697000													8	6					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77170646	77170646	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:77170646C>T	ENST00000253506.5	+	2	740	c.371C>T	c.(370-372)tCg>tTg	p.S124L	NFATC1_ENST00000545796.1_Intron|NFATC1_ENST00000586434.1_Missense_Mutation_p.S111L|NFATC1_ENST00000592223.1_Missense_Mutation_p.S111L|NFATC1_ENST00000318065.5_Missense_Mutation_p.S111L|NFATC1_ENST00000587635.1_Missense_Mutation_p.S124L|NFATC1_ENST00000542384.1_Missense_Mutation_p.S124L|NFATC1_ENST00000591814.1_Missense_Mutation_p.S124L|NFATC1_ENST00000397790.2_Intron|NFATC1_ENST00000427363.2_Missense_Mutation_p.S124L|NFATC1_ENST00000329101.4_Missense_Mutation_p.S111L	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	124					intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GAGATAACCTCGTGCTTGGGC	0.627000													9	50					0	0	1	0	0
RANBP3	8498	broad.mit.edu	37	19	5931433	5931433	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:5931433A>T	ENST00000340578.6	-	8	732	c.675T>A	c.(673-675)gaT>gaA	p.D225E	RANBP3_ENST00000591092.1_Missense_Mutation_p.D157E|RANBP3_ENST00000439268.2_Missense_Mutation_p.D225E|RANBP3_ENST00000541471.1_Missense_Mutation_p.D97E|RANBP3_ENST00000034275.8_Missense_Mutation_p.D157E	NM_003624.2|NM_007320.2|NM_007322.2	NP_003615.2|NP_015559.2|NP_015561.1	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3	225					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	18						CACACACCTCATCGGCAGCTT	0.652000													20	27					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175355234	175355234	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:175355234C>T	ENST00000367674.2	-	8	2419	c.1711G>A	c.(1711-1713)Gag>Aag	p.E571K	TNR_ENST00000263525.2_Missense_Mutation_p.E571K			Q92752	TENR_HUMAN	tenascin R		Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ACTGACACCTCGTATCGGGAG	0.637000													14	206					0	0	1	0	0
ZCCHC9	84240	broad.mit.edu	37	5	80600669	80600669	+	Silent	SNP	A	A	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:80600669A>C	ENST00000254037.2	+	1	3248	c.93A>C	c.(91-93)ggA>ggC	p.G31G	ZCCHC9_ENST00000438268.2_Silent_p.G31G|ZCCHC9_ENST00000407610.3_Silent_p.G31G|ZCCHC9_ENST00000506458.1_Intron|ZCCHC9_ENST00000380199.5_Silent_p.G31G			Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9	31							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)	13		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)		CCTTTGAGGGAACAAGCCAAA	0.423000													22	50					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122261661	122261661	+	Silent	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:122261661C>T	ENST00000334010.7	-	5	1399	c.978G>A	c.(976-978)tcG>tcA	p.S326S	CADPS2_ENST00000412584.2_Silent_p.S326S|CADPS2_ENST00000313070.7_Silent_p.S326S|CADPS2_ENST00000449022.2_Silent_p.S326S	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	326					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding	p.S326S(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						GACCACCTTTCGAAACTGGAA	0.368000													17	69					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50976988	50976988	+	Silent	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:50976988C>T	ENST00000442544.2	+	23	3964	c.3348C>T	c.(3346-3348)atC>atT	p.I1116I	DCC_ENST00000581580.1_Silent_p.I751I	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1116					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TAGTGGTCATCGTGGCTGTGA	0.512000													9	28					0	0	1	0	0
IL10RA	3587	broad.mit.edu	37	11	117864081	117864081	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:117864081C>T	ENST00000227752.3	+	4	613	c.493C>T	c.(493-495)Cga>Tga	p.R165*	IL10RA_ENST00000533700.1_3'UTR|IL10RA_ENST00000541785.1_Nonsense_Mutation_p.R145*|IL10RA_ENST00000545409.1_Nonsense_Mutation_p.R16*	NM_001558.3	NP_001549.2	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha	165						integral to membrane|plasma membrane	interleukin-10 receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		CAGTCACTTCCGAGAGTATGA	0.557000													13	56					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:197348739G>C	ENST00000418868.1	-	0	520					NR_003266.2																						TAATTTTCTAGCTGTGAAAGA	0.398000													5	121					0	0	1	0	0
GNAI3	2773	broad.mit.edu	37	1	110128959	110128959	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:110128959G>A	ENST00000369851.4	+	6	822	c.712G>A	c.(712-714)Gag>Aag	p.E238K		NM_006496.3	NP_006487.1	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	238					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			NS(1)|endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		GGCTGAGGACGAGGAGATGGT	0.413000													41	112					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72946563	72946563	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:72946563T>A	ENST00000262209.4	-	22	2812	c.2605A>T	c.(2605-2607)Act>Tct	p.T869S	RP11-383H13.1_ENST00000457356.4_Intron|RP11-383H13.1_ENST00000537896.1_Intron|RP11-383H13.1_ENST00000524152.1_Intron|TRPA1_ENST00000519720.1_5'UTR	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	869						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	CTCAACAAAGTTTTCAAAATT	0.294000													14	53					0	0	1	0	0
ZNF35	7584	broad.mit.edu	37	3	44692638	44692638	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:44692638G>A	ENST00000396056.2	+	2	314	c.79G>A	c.(79-81)Gaa>Aaa	p.E27K	RP11-944L7.4_ENST00000457331.1_RNA|ZNF35_ENST00000296092.3_Missense_Mutation_p.E27K|ZNF35_ENST00000542250.1_5'UTR|ZNF35_ENST00000399560.2_Missense_Mutation_p.E27K|ZNF35_ENST00000453164.1_Missense_Mutation_p.E27K	NM_003420.3	NP_003411.3	P13682	ZNF35_HUMAN	zinc finger protein 35	27	Globular domain.|Poly-Glu.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	12		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		GGAAGAAGAAGAAAACTTCCC	0.542000													10	55					0	0	1	0	0
HACL1	26061	broad.mit.edu	37	3	15621475	15621475	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:15621475T>C	ENST00000321169.5	-	9	1112	c.745A>G	c.(745-747)Atg>Gtg	p.M249V	HACL1_ENST00000456194.2_Missense_Mutation_p.M222V|HACL1_ENST00000457447.2_Missense_Mutation_p.M223V|HACL1_ENST00000451445.2_Missense_Mutation_p.M167V|HACL1_ENST00000435217.2_Intron	NM_012260.2	NP_036392.2	Q9UJ83	HACL1_HUMAN	2-hydroxyacyl-CoA lyase 1	249					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding			NS(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	16						CCCTTCCCCATAGGGGTGGGC	0.443000													36	55					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4968004	4968004	+	Silent	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chrY:4968004C>T	ENST00000333703.4	+	5	2865	c.2352C>T	c.(2350-2352)ttC>ttT	p.F784F	PCDH11Y_ENST00000215473.6_Silent_p.F795F|PCDH11Y_ENST00000362095.5_Silent_p.F795F	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	795	Cadherin 7.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						ATTCTCTCTTCAGTGTTGTAA	0.423000													8	130					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178936981	178936981	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:178936981C>T	ENST00000286063.6	-	1	501	c.184G>A	c.(184-186)Gct>Act	p.A62T	PDE11A_ENST00000358450.4_Intron	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A						platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GTGCTGTGAGCCAAGCTGCTG	0.627000									Primary Pigmented Nodular Adrenocortical Disease, Familial				9	16					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32633772	32633772	+	Silent	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:32633772G>A	ENST00000242310.4	-	1	1895	c.1806C>T	c.(1804-1806)acC>acT	p.T602T	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	602					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCCCTCCAAAGGTGCCCCGAA	0.483000													55	126					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3319746	3319746	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:3319746C>T	ENST00000336727.3	+	2	2753	c.1849C>T	c.(1849-1851)Cga>Tga	p.R617*	RGS12_ENST00000344733.5_Nonsense_Mutation_p.R617*|RGS12_ENST00000382788.3_Nonsense_Mutation_p.R617*|RGS12_ENST00000543385.1_Nonsense_Mutation_p.R617*	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	617						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGGTCCCCATCGAAATGTTCG	0.582000													27	107					0	0	1	0	0
FBXL17	64839	broad.mit.edu	37	5	107559915	107559915	+	Silent	SNP	T	T	C	rs112049764	byFrequency	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:107559915T>C	ENST00000542267.1	-	5	1927	c.1521A>G	c.(1519-1521)tcA>tcG	p.S507S	FBXL17_ENST00000496714.1_Silent_p.S109S|FBXL17_ENST00000359660.5_Silent_p.S109S	NM_001163315.2	NP_001156787.2	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	507										endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		ATGCTTTCACTGACTGATCTG	0.433000													3	36					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145635380	145635380	+	Missense_Mutation	SNP	G	G	A	rs147064425		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:145635380G>A	ENST00000296575.3	+	9	2082	c.1427G>A	c.(1426-1428)aGt>aAt	p.S476N		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	476						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TTTCCAGAAAGTGAGCCATCA	0.353000													10	34					0	0	1	0	0
REXO1	57455	broad.mit.edu	37	19	1828181	1828181	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:1828181G>T	ENST00000170168.4	-	2	701	c.607C>A	c.(607-609)Ccc>Acc	p.P203T	REXO1_ENST00000587524.1_5'UTR	NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	203						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGCCTTGGGGACGTATTCC	0.692000													5	22					0.184627	0.184627	1	1	0
GALNT15	117248	broad.mit.edu	37	3	16268952	16268952	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:16268952G>T	ENST00000339732.5	+	10	2368	c.1865G>T	c.(1864-1866)gGa>gTa	p.G622V	GALNT15_ENST00000437509.1_Intron	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		CCGTGTGATGGAAAAGCCCGC	0.428000													19	30					1.10513e-12	1.22991e-12	1	1	0
CAMTA1	23261	broad.mit.edu	37	1	7724545	7724545	+	Silent	SNP	G	G	A	rs142993717		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:7724545G>A	ENST00000303635.7	+	9	2145	c.1938G>A	c.(1936-1938)acG>acA	p.T646T	CAMTA1_ENST00000439411.2_Silent_p.T646T	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	646					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TGATGCCCACGGTGAAAACGG	0.637000			T	WWTR1	epitheliod hemangioendothelioma								33	161					0	0	1	0	0
LDLRAD4	753	broad.mit.edu	37	18	13645279	13645279	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:13645279C>T	ENST00000361205.4	+	7	1212	c.544C>T	c.(544-546)Cct>Tct	p.P182S	LDLRAD4_ENST00000587757.1_Missense_Mutation_p.P145S|LDLRAD4_ENST00000359446.5_Missense_Mutation_p.P182S|RP11-701H16.4_ENST00000588397.1_RNA|LDLRAD4_ENST00000586765.1_Missense_Mutation_p.P127S|LDLRAD4_ENST00000592991.1_Missense_Mutation_p.P84S|LDLRAD4_ENST00000399848.3_Missense_Mutation_p.P164S|LDLRAD4_ENST00000585931.1_Missense_Mutation_p.P105S	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		AGAGCCACCTCCTTACCAGGG	0.607000													23	225					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71054178	71054178	+	Missense_Mutation	SNP	T	T	C	rs117718337		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr16:71054178T>C	ENST00000393567.2	-	22	3379	c.3229A>G	c.(3229-3231)Ata>Gta	p.I1077V	HYDIN_ENST00000448089.2_Missense_Mutation_p.I1029V	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1077			I -> V (in dbSNP:rs6416709).					p.I1077V(3)|p.I1029V(3)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				ATGTTCTTTATGGCCAAGGGC	0.418000													4	52					0	0	1	0	0
COG6	57511	broad.mit.edu	37	13	40293396	40293396	+	Silent	SNP	T	T	G	rs61754105	byFrequency	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr13:40293396T>G	ENST00000416691.1	+	14	1408	c.1308T>G	c.(1306-1308)ctT>ctG	p.L436L	COG6_ENST00000455146.3_Silent_p.L436L	NM_001145079.1	NP_001138551.1	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6	436					protein transport	Golgi membrane|Golgi transport complex				NS(1)|kidney(2)|large_intestine(5)|lung(4)|skin(1)	13		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		CACCTGATCTTGGACCAAGTT	0.368000													4	69					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177927476	177927476	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:177927476C>T	ENST00000308284.6	-	10	1245	c.1156G>A	c.(1156-1158)Gct>Act	p.A386T	SEC16B_ENST00000464631.2_Missense_Mutation_p.A387T|RP4-798P15.3_ENST00000354921.3_RNA	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	386					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						AGCAGCTCAGCGATGTCAGAC	0.572000													9	100					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72300920	72300920	+	Silent	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr10:72300920C>T	ENST00000263563.6	+	16	2239	c.1971C>T	c.(1969-1971)ttC>ttT	p.F657F		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		GCACTGGCTTCGTGTTCAGCT	0.632000													13	49					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965564	88965564	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:88965564G>C	ENST00000333190.4	+	4	3877	c.3268G>C	c.(3268-3270)Gag>Cag	p.E1090Q		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1090						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TGATTCAACAGAGACCCAAGA	0.363000										HNSCC(36;0.09)			18	49					0	0	1	0	0
NELFA	7469	broad.mit.edu	37	4	1985773	1985773	+	Silent	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:1985773C>T	ENST00000382882.3	-	9	2254	c.1137G>A	c.(1135-1137)gcG>gcA	p.A379A	NELFA_ENST00000411638.2_Silent_p.A368A|NELFA_ENST00000542778.1_Silent_p.A233A					negative elongation factor complex member A																		GCTTGAACTGCGCTGGCAACG	0.716000													4	14					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208234158	208234158	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:208234158C>A	ENST00000367033.3	-	13	3368	c.2611G>T	c.(2611-2613)Gaa>Taa	p.E871*		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	871	IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GTCCCTCCTTCCGGCGGTCCA	0.602000													18	29					0.00887093	0.00918141	1	1	0
SH3GL1	6455	broad.mit.edu	37	19	4362650	4362650	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:4362650G>A	ENST00000269886.3	-	8	990	c.812C>T	c.(811-813)tCc>tTc	p.S271F	SH3GL1_ENST00000598564.1_Missense_Mutation_p.S207F|SH3GL1_ENST00000417295.2_Missense_Mutation_p.S223F	NM_003025.3	NP_003016.1	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	271					central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			NS(1)|endometrium(2)|kidney(16)|large_intestine(3)|lung(2)|ovary(2)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		GCCCCCGTTGGACTGCTCAGG	0.642000			T	MLL	AL								16	54					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46243818	46243818	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:46243818G>A	ENST00000334344.6	+	15	2084		c.e15-1		ARID2_ENST00000479608.1_Splice_Site|ARID2_ENST00000444670.1_Splice_Site|ARID2_ENST00000422737.1_Splice_Site	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CATATTTTCAGGAATCCCTCA	0.333000			"""N, S, F"""		hepatocellular carcinoma								33	53					0	0	1	0	0
ERP29	10961	broad.mit.edu	37	12	112451286	112451286	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:112451286C>T	ENST00000261735.3	+	1	167	c.17C>T	c.(16-18)cCc>cTc	p.P6L	ERP29_ENST00000455836.1_Missense_Mutation_p.P6L	NM_006817.3	NP_006808.1	P30040	ERP29_HUMAN	endoplasmic reticulum protein 29	6					intracellular protein transport|protein folding|protein secretion	endoplasmic reticulum lumen|melanosome	protein disulfide isomerase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	5						GCCGCTGTGCCCCGCGCCGCA	0.682000													14	58					0	0	1	0	0
EPS8	2059	broad.mit.edu	37	12	15807190	15807190	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:15807190G>T	ENST00000281172.5	-	13	1575	c.1139C>A	c.(1138-1140)tCa>tAa	p.S380*	EPS8_ENST00000540613.1_Nonsense_Mutation_p.S120*|EPS8_ENST00000543612.1_Nonsense_Mutation_p.S380*|EPS8_ENST00000542903.1_Nonsense_Mutation_p.S120*|EPS8_ENST00000543523.1_Nonsense_Mutation_p.S380*	NM_004447.5	NP_004438.3	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway substrate 8	380					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		ACTAAGTACTGAACTGGCTAG	0.383000													15	68					2.61681e-11	2.86604e-11	1	1	0
FGFR3	2261	broad.mit.edu	37	4	1803704	1803704	+	Silent	SNP	T	T	C	rs2234909	byFrequency	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:1803704T>C	ENST00000340107.4	+	7	1138	c.882T>C	c.(880-882)aaT>aaC	p.N294N	FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000481110.2_Silent_p.N294N|FGFR3_ENST00000352904.1_Silent_p.N294N|FGFR3_ENST00000440486.2_Silent_p.N294N|FGFR3_ENST00000260795.2_Silent_p.N294N|FGFR3_ENST00000412135.2_Silent_p.N294N	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	294	Ig-like C2-type 3.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.N294N(5)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	TGGAGGTGAATGGCAGCAAGG	0.672000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				6	23					0	0	1	0	0
PARD6A	50855	broad.mit.edu	37	16	67695381	67695381	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr16:67695381C>A	ENST00000458121.2	+	2	178	c.87C>A	c.(85-87)ttC>ttA	p.F29L	PARD6A_ENST00000219255.3_Missense_Mutation_p.F29L|PARD6A_ENST00000602551.1_Missense_Mutation_p.F29L	NM_001037281.1|NM_016948.2	NP_001032358.1|NP_058644.1	Q9NPB6	PAR6A_HUMAN	par-6 family cell polarity regulator alpha	29	Interaction with PRKCI and PRKCZ.|OPR.				cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(2)	6		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		TCCGACGCTTCGCGCTGCCTC	0.662000													18	67					3.51602e-12	3.89206e-12	1	1	0
PPP1R13L	10848	broad.mit.edu	37	19	45895561	45895561	+	Silent	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:45895561C>T	ENST00000418234.2	-	8	1470	c.1392G>A	c.(1390-1392)ccG>ccA	p.P464P	PPP1R13L_ENST00000360957.5_Silent_p.P464P	NM_001142502.1	NP_001135974.1	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13 like	464	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CCTCTATCTCCGGCTCAGGCT	0.647000													13	82					0	0	1	0	0
PNPLA3	80339	broad.mit.edu	37	22	44333050	44333050	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr22:44333050G>C	ENST00000216180.3	+	6	1050	c.877G>C	c.(877-879)Gct>Cct	p.A293P	PNPLA3_ENST00000423180.2_Missense_Mutation_p.A289P	NM_025225.2	NP_079501.2	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	293					triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|prostate(1)|skin(1)|stomach(2)	19		Ovarian(80;0.024)|all_neural(38;0.0416)				GGCTGCCTTGGCTGTGAGGCT	0.617000													10	29					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117266864	117266864	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:117266864C>T	ENST00000278935.3	+	25	3331	c.3184C>T	c.(3184-3186)Cat>Tat	p.H1062Y	CEP164_ENST00000533706.1_3'UTR	NM_001271933.1|NM_014956.4	NP_001258862.1|NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1062					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GCCAGATCTCCATATTGAGGA	0.572000													29	110					0	0	1	0	0
XRN2	22803	broad.mit.edu	37	20	21321376	21321376	+	Silent	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr20:21321376C>T	ENST00000377191.3	+	15	1391	c.1296C>T	c.(1294-1296)ttC>ttT	p.F432F	XRN2_ENST00000430571.2_Silent_p.F356F|XRN2_ENST00000539513.1_Silent_p.F378F	NM_012255.3	NP_036387.2	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	432					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(5)|kidney(6)|large_intestine(10)|lung(12)|ovary(1)|skin(5)	39						AACCAGCTTTCACTCCTAGTG	0.383000													5	106					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30033452	30033452	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:30033452G>C	ENST00000328224.6	-	2	2007	c.774C>G	c.(772-774)ttC>ttG	p.F258L		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	258						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CCAACTGATAGAACTTCACCT	0.507000													19	59					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130840202	130840202	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:130840202G>A	ENST00000245255.3	+	12	1666	c.1394G>A	c.(1393-1395)gGt>gAt	p.G465D		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	465					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ATTCACCAAGGTGGAAAAACA	0.453000													10	106					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154595651	154595651	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:154595651G>C	ENST00000404039.1	+	14	1880	c.1293G>C	c.(1291-1293)gaG>gaC	p.E431D	DPP6_ENST00000427557.1_Missense_Mutation_p.E388D|DPP6_ENST00000377770.3_Missense_Mutation_p.E495D|DPP6_ENST00000332007.3_Missense_Mutation_p.E433D	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	495					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CCTACGATGAGAAGGGGAATA	0.502000													4	12					0	0	1	0	0
REXO4	57109	broad.mit.edu	37	9	136277903	136277903	+	Silent	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:136277903G>A	ENST00000371942.3	-	3	910	c.711C>T	c.(709-711)ttC>ttT	p.F237F	REXO4_ENST00000478037.1_5'UTR|REXO4_ENST00000371935.2_Intron	NM_020385.2	NP_065118.2	Q9GZR2	REXO4_HUMAN	REX4, RNA exonuclease 4 homolog (S. cerevisiae)	237						nucleolus	exonuclease activity|nucleic acid binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(4)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	15				OV - Ovarian serous cystadenocarcinoma(145;8.58e-08)|Epithelial(140;9.55e-07)|all cancers(34;1.05e-05)		CGTACCCGCCGAAGGCCTGCT	0.617000													12	24					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46495137	46495137	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:46495137G>C	ENST00000361297.2	+	19	2501		c.e19-1		MAST2_ENST00000372009.2_Splice_Site|MAST2_ENST00000477968.1_3'UTR	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2						regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GATGACTTCAGATGAGATTGT	0.547000													3	38					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31326233	31326233	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:31326233A>G	ENST00000269197.5	+	12	6421	c.6421A>G	c.(6421-6423)Aaa>Gaa	p.K2141E		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	2141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						AGCTGCTCAGAAAATGCAGGT	0.408000													34	83					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131593323	131593323	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:131593323G>A	ENST00000261654.5	+	18	2501	c.1942G>A	c.(1942-1944)Gca>Aca	p.A648T	GPR133_ENST00000376682.4_Missense_Mutation_p.A334T|GPR133_ENST00000543617.1_Missense_Mutation_p.A167T|GPR133_ENST00000535015.1_Missense_Mutation_p.A680T	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	648					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.A648T(1)		NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GAGTGCCTTCGCATGGATGCT	0.567000													31	145					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637272	248637272	+	Silent	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:248637272C>T	ENST00000359594.2	+	1	646	c.621C>T	c.(619-621)tgC>tgT	p.C207C		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.C207*(1)		breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTACCTGTGCTGCATCCTCA	0.537000													276	140					0	0	1	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151130805	151130805	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:151130805C>T	ENST00000367328.1	+	11	1525	c.1213C>T	c.(1213-1215)Cgc>Tgc	p.R405C	PLEKHG1_ENST00000358517.2_Missense_Mutation_p.R405C	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	405	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GCAAGACAAACGCCTCTGGGT	0.493000													15	27					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17760337	17760337	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:17760337A>G	ENST00000428389.2	-	14	1762	c.1763T>C	c.(1762-1764)aTc>aCc	p.I588T	UNC13A_ENST00000551649.1_Missense_Mutation_p.I500T|UNC13A_ENST00000252773.7_Missense_Mutation_p.I500T|UNC13A_ENST00000550896.1_Missense_Mutation_p.I500T|UNC13A_ENST00000552293.1_Missense_Mutation_p.I500T|UNC13A_ENST00000519716.2_Missense_Mutation_p.I500T			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	500					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CACGAGTGGGATAGGTTTCCT	0.572000													38	83					0	0	1	0	0
MOSPD2	158747	broad.mit.edu	37	X	14891876	14891876	+	Silent	SNP	G	G	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chrX:14891876G>T	ENST00000380492.3	+	2	163	c.75G>T	c.(73-75)gtG>gtT	p.V25V	MOSPD2_ENST00000482354.1_Silent_p.V25V|MOSPD2_ENST00000497603.2_Silent_p.V25V	NM_001177475.1|NM_152581.3	NP_001170946.1|NP_689794.1	Q8NHP6	MSPD2_HUMAN	motile sperm domain containing 2	25						integral to membrane	structural molecule activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	Hepatocellular(33;0.183)					CTGAGTATGTGACAGGTGGGT	0.498000													4	62					0.00024832	0.000262256	1	1	0
PIGF	5281	broad.mit.edu	37	2	46840834	46840834	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:46840834C>G	ENST00000281382.6	-	3	489	c.319G>C	c.(319-321)Gag>Cag	p.E107Q	PIGF_ENST00000495933.1_5'UTR|PIGF_ENST00000306465.4_Splice_Site_p.E107Q	NM_002643.3	NP_002634.1	Q07326	PIGF_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class F	107					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	ethanolaminephosphotransferase activity			breast(1)|endometrium(1)|lung(1)|stomach(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CAAACTTACTCTATCAGTGGT	0.303000													4	15					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19497352	19497352	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:19497352C>T	ENST00000375267.2	-	26	3550	c.3547G>A	c.(3547-3549)Gaa>Aaa	p.E1183K	UBR4_ENST00000375254.3_Missense_Mutation_p.E1183K|UBR4_ENST00000375217.2_Missense_Mutation_p.E1183K|UBR4_ENST00000375226.2_Missense_Mutation_p.E1183K			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	1183					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GTTCCCTCTTCATTAAAGTTT	0.453000													48	49					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75265975	75265975	+	Silent	SNP	A	A	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr14:75265975A>G	ENST00000325680.7	+	5	4099	c.3975A>G	c.(3973-3975)gaA>gaG	p.E1325E	YLPM1_ENST00000552421.1_Intron|YLPM1_ENST00000238571.3_Silent_p.E1130E	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGTTTCGTGAACGGGATATTC	0.443000													19	64					0	0	1	0	0
FAM86DP	692099	broad.mit.edu	37	3	75478362	75478362	+	RNA	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:75478362C>T	ENST00000459803.1	-	0	303					NR_024241.1																						ACAGCTCGTCCAAAGCCTCCA	0.542000													3	39					0	0	1	0	0
PPIE	10450	broad.mit.edu	37	1	40214744	40214744	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:40214744C>G	ENST00000470213.1	+	7	554	c.554C>G	c.(553-555)tCa>tGa	p.S185*	PPIE_ENST00000372830.1_Silent_p.L226L|PPIE_ENST00000324379.5_Silent_p.L226L|PPIE_ENST00000356511.2_Silent_p.L226L			Q9UNP9	PPIE_HUMAN	peptidylprolyl isomerase E (cyclophilin E)	0	PPIase cyclophilin-type.				protein folding|regulation of transcription, DNA-dependent	catalytic step 2 spliceosome	cyclosporin A binding|nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|RNA binding			kidney(3)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	9	all_cancers(7;1.63e-13)|all_lung(5;2.27e-16)|all_epithelial(6;1.35e-15)|Lung NSC(20;1.49e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;2.7e-17)|all cancers(16;5.5e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			ACTTTATCCTCAAGCATACGG	0.547000													16	70					0	0	1	0	0
ICAM5	7087	broad.mit.edu	37	19	10402336	10402336	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:10402336G>A	ENST00000221980.4	+	3	587	c.524G>A	c.(523-525)cGa>cAa	p.R175Q	ICAM5_ENST00000586004.1_3'UTR	NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	175	Ig-like C2-type 2.				cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			GAACCACCCCGAGCGCGGGGC	0.731000													10	54					0	0	1	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90573429	90573429	+	RNA	SNP	T	T	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:90573429T>A	ENST00000551025.1	+	0	3438							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TTGACAATACTATGCATTGTG	0.418000													20	11					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152551705	152551705	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:152551705G>A	ENST00000367255.5	-	115	21773	c.21172C>T	c.(21172-21174)Caa>Taa	p.Q7058*	SYNE1_ENST00000356820.4_Nonsense_Mutation_p.Q1582*|SYNE1_ENST00000341594.5_Nonsense_Mutation_p.Q6670*|SYNE1_ENST00000265368.4_Nonsense_Mutation_p.Q7058*|SYNE1_ENST00000423061.1_Nonsense_Mutation_p.Q6987*|SYNE1_ENST00000448038.1_Nonsense_Mutation_p.Q6987*	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7058					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGTGCATTTTGAACAGAAGCC	0.388000										HNSCC(10;0.0054)			15	120					0	0	1	0	0
FZD3	7976	broad.mit.edu	37	8	28384671	28384671	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:28384671G>A	ENST00000240093.3	+	5	872	c.394G>A	c.(394-396)Gat>Aat	p.D132N	FZD3_ENST00000537916.1_Missense_Mutation_p.D132N	NM_017412.3	NP_059108.1	Q9NPG1	FZD3_HUMAN	frizzled family receptor 3	132	FZ.				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(15)|ovary(1)|prostate(1)|skin(1)	41		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		TAGGTTCCCAGATTGTGATGA	0.423000													26	81					0	0	1	0	0
TM7SF2	7108	broad.mit.edu	37	11	64882277	64882277	+	Silent	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:64882277C>G	ENST00000279263.7	+	6	858	c.696C>G	c.(694-696)ctC>ctG	p.L232L	TM7SF2_ENST00000531029.1_3'UTR|TM7SF2_ENST00000540748.1_Silent_p.L116L|TM7SF2_ENST00000345348.5_Silent_p.L232L	NM_003273.2	NP_003264.2	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	232					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCCAGTTGCTCTACGTGGGTG	0.607000													10	66					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46660807	46660807	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:46660807C>G	ENST00000544460.1	+	1	5196	c.4942C>G	c.(4942-4944)Caa>Gaa	p.Q1648E	TDRD6_ENST00000316081.6_Missense_Mutation_p.Q1648E	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1648					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			ATTATGTTCTCAAGAGGGAAA	0.383000													14	104					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131388859	131388859	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:131388859G>A	ENST00000358161.5	+	49	6582	c.6469G>A	c.(6469-6471)Gag>Aag	p.E2157K	SPTAN1_ENST00000372739.3_Missense_Mutation_p.E2157K|SPTAN1_ENST00000372731.4_Missense_Mutation_p.E2152K			Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2152					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						CCAGCTGGCCGAGCTGGACCG	0.597000													13	36					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40917795	40917795	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr15:40917795G>T	ENST00000346991.5	+	11	5801	c.5411G>T	c.(5410-5412)aGa>aTa	p.R1804I	CASC5_ENST00000399668.2_Missense_Mutation_p.R1778I			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	1804					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		AAAAAAATCAGAAAAAATGAG	0.333000													5	37					5.9392e-07	6.33719e-07	1	1	0
NCOR2	9612	broad.mit.edu	37	12	124820110	124820110	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:124820110T>C	ENST00000356219.3	-	40	6360	c.6205A>G	c.(6205-6207)Acc>Gcc	p.T2069A	NCOR2_ENST00000404121.2_Missense_Mutation_p.T1623A|NCOR2_ENST00000404621.1_Missense_Mutation_p.T2052A|NCOR2_ENST00000397355.1_Missense_Mutation_p.T2053A|NCOR2_ENST00000405201.1_Missense_Mutation_p.T2062A|NCOR2_ENST00000429285.2_Missense_Mutation_p.T2052A	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	2073					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TTGTCGTGGGTCAGACTGGGT	0.677000													4	21					0	0	1	0	0
TREM1	54210	broad.mit.edu	37	6	41254347	41254347	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:41254347G>A	ENST00000591620.1	-	1	73	c.47C>T	c.(46-48)tCa>tTa	p.S16L	TREM1_ENST00000589614.1_Missense_Mutation_p.S16L|TREM1_ENST00000244709.4_Missense_Mutation_p.S16L|TREM1_ENST00000334475.6_Missense_Mutation_p.S16L	NM_001242589.1	NP_001229518.1	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	16					blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			NS(1)|breast(2)|endometrium(2)|large_intestine(5)|lung(5)|skin(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	TGTCTTACCTGAGACAAAGAG	0.577000													10	79					0	0	1	0	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													4	22					0	0	1	0	0
C4orf40	401137	broad.mit.edu	37	4	71021792	71021792	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:71021792G>A	ENST00000344526.5	+	2	262	c.73G>A	c.(73-75)Gag>Aag	p.E25K	C4orf40_ENST00000502294.1_Missense_Mutation_p.E25K|C4orf40_ENST00000502441.2_Intron	NM_214711.3	NP_999876.2	Q6MZM9	CD040_HUMAN	chromosome 4 open reading frame 40	25						extracellular region				breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						CTTCATTGGTGAGGTAAAACT	0.264000													4	52					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164271826	164271826	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:164271826C>T	ENST00000515560.1	+	4	1923	c.401C>T	c.(400-402)tCa>tTa	p.S134L	NPY5R_ENST00000506953.1_Missense_Mutation_p.S134L|NPY5R_ENST00000338566.3_Missense_Mutation_p.S134L			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	134					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane		p.L130fs*9(1)		NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				ATTTTAATATCAATTGCCATT	0.358000													42	159					0	0	1	0	0
ZNHIT2	741	broad.mit.edu	37	11	64884048	64884048	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:64884048C>T	ENST00000310597.4	-	1	1122	c.1078G>A	c.(1078-1080)Gac>Aac	p.D360N		NM_014205.2	NP_055020.1	Q9UHR6	ZNHI2_HUMAN	zinc finger, HIT-type containing 2	360							metal ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						CTGGCGCAGTCTAGGGCCAGG	0.647000													15	64					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42718627	42718627	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:42718627G>A	ENST00000230882.4	+	10	1208	c.1018G>A	c.(1018-1020)Gac>Aac	p.D340N	GHR_ENST00000357703.3_Missense_Mutation_p.D318N|GHR_ENST00000513625.1_3'UTR|GHR_ENST00000537449.1_Missense_Mutation_p.D153N	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	340					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CCACAGTGATGACTCTTGGGT	0.378000													130	143					0	0	1	0	0
NIPAL1	152519	broad.mit.edu	37	4	48035086	48035086	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:48035086G>C	ENST00000295461.5	+	4	513	c.447G>C	c.(445-447)ttG>ttC	p.L149F	NIPAL1_ENST00000508180.1_3'UTR	NM_207330.1	NP_997213.1	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	149						integral to membrane				endometrium(2)|large_intestine(1)|lung(3)|skin(2)	8						TGGGTGCTTTGAGTGTTCTCA	0.428000													13	43					0	0	1	0	0
CLCN3	1182	broad.mit.edu	37	4	170608906	170608906	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:170608906C>A	ENST00000513761.1	+	4	975	c.416C>A	c.(415-417)tCa>tAa	p.S139*	CLCN3_ENST00000360642.3_Nonsense_Mutation_p.S139*|CLCN3_ENST00000347613.4_Nonsense_Mutation_p.S139*|CLCN3_ENST00000504131.2_Nonsense_Mutation_p.S122*	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	139					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		GGATTGGCATCAGGTAAAGAA	0.358000													12	62					4.84862e-15	5.51463e-15	1	1	0
NCOR2	9612	broad.mit.edu	37	12	124832794	124832794	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:124832794G>A	ENST00000356219.3	-	30	4087	c.3932C>T	c.(3931-3933)aCg>aTg	p.T1311M	NCOR2_ENST00000404121.2_Missense_Mutation_p.T865M|NCOR2_ENST00000404621.1_Missense_Mutation_p.T1294M|NCOR2_ENST00000397355.1_Missense_Mutation_p.T1295M|NCOR2_ENST00000405201.1_Missense_Mutation_p.T1304M|NCOR2_ENST00000429285.2_Missense_Mutation_p.T1294M	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1312					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGGGGCGGCCGTCTCATGGGG	0.612000											OREG0022238	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	66					0	0	1	0	0
HOXC8	3224	broad.mit.edu	37	12	54405067	54405067	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:54405067G>A	ENST00000040584.4	+	2	868	c.631G>A	c.(631-633)Gat>Aat	p.D211N	RP11-834C11.12_ENST00000513209.1_Intron	NM_022658.3	NP_073149.1	P31273	HXC8_HUMAN	homeobox C8	211						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	8						GAACAACAAGGATAAACTGCC	0.488000													17	49					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145573799	145573799	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:145573799G>C	ENST00000296575.3	+	2	977	c.322G>C	c.(322-324)Gag>Cag	p.E108Q	HHIP_ENST00000434550.2_Missense_Mutation_p.E108Q|HHIP_ENST00000511314.1_3'UTR|HHIP-AS1_ENST00000512359.1_RNA	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	108						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GAAGTTACTGGAGGAAATCAA	0.393000													19	92					0	0	1	0	0
C9orf172	389813	broad.mit.edu	37	9	139739888	139739888	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:139739888C>T	ENST00000436881.1	+	1	1022	c.1022C>T	c.(1021-1023)tCc>tTc	p.S341F		NM_001080482.2	NP_001073951.2	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	341	Pro-rich.									endometrium(2)|large_intestine(1)|lung(6)	9						GAACCGCCCTCCCGCTCCTAC	0.701000													5	17					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	6069450	6069450	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chrX:6069450T>A	ENST00000381095.3	-	2	685	c.58A>T	c.(58-60)Atg>Ttg	p.M20L	NLGN4X_ENST00000469740.1_5'UTR|NLGN4X_ENST00000381092.1_Missense_Mutation_p.M20L|NLGN4X_ENST00000275857.6_Missense_Mutation_p.M20L|NLGN4X_ENST00000538097.1_Missense_Mutation_p.M20L|NLGN4X_ENST00000381093.2_Missense_Mutation_p.M20L	NM_001282145.1|NM_001282146.1|NM_181332.1	NP_001269074.1|NP_001269075.1|NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	20					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						GAGTTTAACATGACGCAGACC	0.498000													25	13					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108719425	108719425	+	Silent	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:108719425C>T	ENST00000232603.5	-	21	2248	c.2166G>A	c.(2164-2166)acG>acA	p.T722T	MORC1_ENST00000483760.1_Silent_p.T701T	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	722					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						CTGAATCACTCGTGTTCTCAT	0.363000													4	82					0	0	1	0	0
ZNHIT2	741	broad.mit.edu	37	11	64884237	64884237	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:64884237C>A	ENST00000310597.4	-	1	933	c.889G>T	c.(889-891)Gag>Tag	p.E297*		NM_014205.2	NP_055020.1	Q9UHR6	ZNHI2_HUMAN	zinc finger, HIT-type containing 2	297							metal ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						GTCGGGCCCTCGCCCAGCAGG	0.711000													13	44					1.5842e-08	1.70797e-08	1	1	0
ABHD16B	140701	broad.mit.edu	37	20	62493636	62493636	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr20:62493636T>C	ENST00000369916.3	+	1	1071	c.743T>C	c.(742-744)gTt>gCt	p.V248A		NM_080622.3	NP_542189.1	Q9H3Z7	ABHGB_HUMAN	abhydrolase domain containing 16B	248							hydrolase activity			endometrium(2)|kidney(1)|lung(3)	6						GGCTGGTCTGTTGGCGGCTTC	0.672000													7	18					0	0	1	0	0
ESRRA	2101	broad.mit.edu	37	11	64082320	64082320	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:64082320A>G	ENST00000405666.1	+	5	913	c.679A>G	c.(679-681)Acc>Gcc	p.T227A	ESRRA_ENST00000406310.1_Missense_Mutation_p.T226A|ESRRA_ENST00000000442.6_Missense_Mutation_p.T227A	NM_001282450.1	NP_001269379.1	P11474	ERR1_HUMAN	estrogen-related receptor alpha	227	Ligand binding domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14						AGCCGTGGCTACCCTCTGTGA	0.612000													12	21					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37622284	37622284	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:37622284G>C	ENST00000297153.7	-	6	1926	c.748C>G	c.(748-750)Ctg>Gtg	p.L250V	MDGA1_ENST00000505425.1_Missense_Mutation_p.L250V|MDGA1_ENST00000434837.3_Missense_Mutation_p.L250V			Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	250	Ig-like 3.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						TTCACCACCAGAGTTTCGTTC	0.617000													43	78					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171086520	171086520	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:171086520C>T	ENST00000367755.4	+	9	1648	c.1537C>T	c.(1537-1539)Cat>Tat	p.H513Y	FMO3_ENST00000542847.1_Missense_Mutation_p.H493Y|FMO3_ENST00000538429.1_Missense_Mutation_p.H450Y|FMO3_ENST00000392085.2_Missense_Mutation_p.H513Y	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	513					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTTCTTTTTCCATTGGCTGAA	0.458000													62	50					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121747574	121747574	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:121747574G>A	ENST00000452319.1	+	14	4144	c.4084G>A	c.(4084-4086)Gct>Act	p.A1362T	GLI2_ENST00000314490.11_Intron|GLI2_ENST00000361492.4_Missense_Mutation_p.A1362T			P10070	GLI2_HUMAN	GLI family zinc finger 2	1362					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GATGGGGGTGGCTACAGCAGG	0.697000													4	7					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57012841	57012841	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:57012841G>C	ENST00000370706.4	+	10	2202	c.1958G>C	c.(1957-1959)cGa>cCa	p.R653P	RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000357489.3_Missense_Mutation_p.R653P|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000589549.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|ZNF451_ENST00000491832.2_Missense_Mutation_p.R653P|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	653					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.R653Q(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ACATTGTACCGACATTGCCAA	0.373000													57	84					0	0	1	0	0
EXOC7	23265	broad.mit.edu	37	17	74097331	74097331	+	Silent	SNP	G	G	A	rs9895541	by1000genomes	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:74097331G>A	ENST00000406660.3	-	4	479	c.438C>T	c.(436-438)aaC>aaT	p.N146N	EXOC7_ENST00000467929.2_Intron|EXOC7_ENST00000405575.4_Intron|EXOC7_ENST00000607838.1_Intron|EXOC7_ENST00000332065.5_Intron|EXOC7_ENST00000411744.2_Intron|EXOC7_ENST00000335146.7_Intron|EXOC7_ENST00000589210.1_Intron	NM_001282314.1	NP_001269243.1	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7	0					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	14			LUSC - Lung squamous cell carcinoma(166;0.187)			AGCTTCTCACGTTATTCTGCG	0.507000													4	66					0	0	1	0	0
CWC27	10283	broad.mit.edu	37	5	64100077	64100077	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:64100077G>C	ENST00000508024.1	+	10	1003	c.802G>C	c.(802-804)Gag>Cag	p.E268Q	CWC27_ENST00000381070.3_Missense_Mutation_p.E268Q			Q6UX04	CWC27_HUMAN	CWC27 spliceosome-associated protein homolog (S. cerevisiae)	268					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(5)|prostate(1)	21						TGAAAGTGCAGAGCATGATGA	0.368000													16	31					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100866463	100866463	+	Missense_Mutation	SNP	G	G	T	rs149659649	byFrequency	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:100866463G>T	ENST00000358544.2	+	56	11032	c.10921G>T	c.(10921-10923)Gct>Tct	p.A3641S	VPS13B_ENST00000357162.2_Missense_Mutation_p.A3616S|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3641					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GCACTATGCCGCTGGGGCCCT	0.552000													22	17					2.37509e-13	2.67198e-13	1	1	0
SPATA22	84690	broad.mit.edu	37	17	3352265	3352265	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:3352265T>C	ENST00000573128.1	-	6	991	c.508A>G	c.(508-510)Aaa>Gaa	p.K170E	SPATA22_ENST00000397168.3_Missense_Mutation_p.K170E|SPATA22_ENST00000355380.4_Missense_Mutation_p.K127E|SPATA22_ENST00000575375.1_Missense_Mutation_p.K170E|SPATA22_ENST00000268981.5_Missense_Mutation_p.K170E|SPATA22_ENST00000572969.1_Missense_Mutation_p.K170E|SPATA22_ENST00000541913.1_Missense_Mutation_p.K154E			Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	170										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)	19						TCGGTTTCTTTGTTGCGAGAT	0.403000													71	175					0	0	1	0	0
SPG20	23111	broad.mit.edu	37	13	36909198	36909198	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr13:36909198G>C	ENST00000451493.1	-	2	987	c.770C>G	c.(769-771)tCt>tGt	p.S257C	SPG20_ENST00000355182.4_Missense_Mutation_p.S257C|SPG20_ENST00000494062.2_Missense_Mutation_p.S257C|SPG20_ENST00000495510.1_5'UTR|SPG20_ENST00000438666.2_Missense_Mutation_p.S257C	NM_001142295.1	NP_001135767.1	Q8N0X7	SPG20_HUMAN	spastic paraplegia 20 (Troyer syndrome)	257					cell death	cytoplasm	ubiquitin protein ligase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	27		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		CGTATCGAGAGAATTATCCAA	0.388000													31	98					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27059176	27059176	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:27059176C>G	ENST00000324856.7	+	4	2184	c.1813C>G	c.(1813-1815)Caa>Gaa	p.Q605E	ARID1A_ENST00000374152.2_Missense_Mutation_p.Q222E|ARID1A_ENST00000457599.2_Missense_Mutation_p.Q605E	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	605					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGAGCTATCTCAAGATTCATT	0.483000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								12	73					0	0	1	0	0
DGKA	1606	broad.mit.edu	37	12	56334764	56334764	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:56334764G>A	ENST00000331886.5	+	13	1555	c.1101G>A	c.(1099-1101)cgG>cgA	p.R367R	DGKA_ENST00000394147.1_Splice_Site_p.R367R|DGKA_ENST00000551156.1_Splice_Site_p.R367R|DGKA_ENST00000549079.2_3'UTR	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	367					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	AGGCTCTGCGGGTACAGGGCT	0.542000													7	27					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137710579	137710579	+	Silent	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:137710579G>A	ENST00000371817.3	+	55	4722	c.4308G>A	c.(4306-4308)ccG>ccA	p.P1436P		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1436	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding	p.P1436P(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGCCCGGACCGGATGGCCTTC	0.697000													4	12					0	0	1	0	0
REM1	28954	broad.mit.edu	37	20	30071976	30071976	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr20:30071976G>A	ENST00000201979.2	+	5	933	c.640G>A	c.(640-642)Gct>Act	p.A214T		NM_014012.4	NP_054731.2	O75628	REM1_HUMAN	RAS (RAD and GEM)-like GTP-binding 1	214					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			kidney(3)|large_intestine(3)|lung(14)|pancreas(2)|upper_aerodigestive_tract(1)	23	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CCGCGCCTGCGCTGTGGTGTT	0.617000													10	6					0	0	1	0	0
EIF4A3	9775	broad.mit.edu	37	17	78115630	78115630	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:78115630C>T	ENST00000269349.3	-	3	481	c.260G>A	c.(259-261)gGa>gAa	p.G87E		NM_014740.3	NP_055555.1	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A3	87	Helicase ATP-binding.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			GGCTGTTTTTCCTGTGCCGGA	0.473000													4	73					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578454	7578454	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:7578454G>A	ENST00000420246.2	-	5	608	c.476C>T	c.(475-477)gCc>gTc	p.A159V	TP53_ENST00000455263.2_Missense_Mutation_p.A159V|TP53_ENST00000413465.2_Missense_Mutation_p.A159V|TP53_ENST00000445888.2_Missense_Mutation_p.A159V|TP53_ENST00000269305.4_Missense_Mutation_p.A159V|TP53_ENST00000359597.4_Missense_Mutation_p.A159V	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	159	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		A -> D (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|A -> G (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(33)|p.0?(8)|p.A159D(7)|p.R158fs(6)|p.R65fs(2)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.R26fs(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.R158fs*11(1)|p.A66V(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.A27V(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGCCATGGCGCGGACGCG	0.627000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	64					0	0	1	0	0
CCDC138	165055	broad.mit.edu	37	2	109403310	109403310	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:109403310delA	ENST00000295124.4	+	1	92	c.32delA	c.(31-33)cagfs	p.Q11fs	CCDC138_ENST00000470608.1_Intron|CCDC138_ENST00000412964.2_Frame_Shift_Del_p.Q11fs	NM_144978.1	NP_659415.1	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	11										endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	14						CCACCGGGGCAGGATTTAGTA	0.667													2	4	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12046124	12046126	+	RNA	DEL	AGC	AGC	-	rs76272937		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:12046124_12046126delAGC	ENST00000432424.2	+	0	245_247							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						AGCCCCAGCAAGCGCCGAcgccg	0.764													2	4	---	---	---	---					
INPP4B	8821	broad.mit.edu	37	4	143003291	143003291	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:143003291delG	ENST00000513000.1	-	26	2968	c.2535delC	c.(2533-2535)gccfs	p.A845fs	INPP4B_ENST00000262992.4_Frame_Shift_Del_p.A845fs|INPP4B_ENST00000508116.1_Frame_Shift_Del_p.A845fs|INPP4B_ENST00000308502.4_Frame_Shift_Del_p.A845fs|INPP4B_ENST00000509777.1_Frame_Shift_Del_p.A845fs	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	845					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TCCTGTCTTTGGCACTTTTAC	0.408													26	53	---	---	---	---					
HLA-F	3134	broad.mit.edu	37	6	29694802	29694803	+	Frame_Shift_Ins	INS	-	-	T	rs17875385		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:29694802_29694803insT	ENST00000259951.7	+	7	1235_1236	c.1179_1180insT	c.(1180-1182)tttfs	p.F394fs	HLA-F_ENST00000440587.2_Intron|HLA-F_ENST00000475996.1_Intron	NM_001098479.1	NP_001091949.1	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	0					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8						TGTGGATCTTGTTTTTTTTGTG	0.535													7	330	---	---	---	---					
TRBV29-1	28558	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													3	4	---	---	---	---					
UBXN8	7993	broad.mit.edu	37	8	30612474	30612474	+	RNA	DEL	T	T	-			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:30612474delT	ENST00000519246.1	+	0	604							O00124	UBXN8_HUMAN	UBX domain protein 8						single fertilization					central_nervous_system(1)|lung(2)	3						GGGTTGGTCGttttttttttt	0.393													3	4	---	---	---	---					
CCDC83	220047	broad.mit.edu	37	11	85593685	85593685	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:85593685delA	ENST00000280245.4	+	4	822	c.310delA	c.(310-312)aagfs	p.K104fs	CCDC83_ENST00000529676.2_Intron|CCDC83_ENST00000376067.1_Frame_Shift_Del_p.K61fs|CCDC83_ENST00000342404.3_Frame_Shift_Del_p.K104fs	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	104										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				GGAAAAATGGAAGTTTGAAAG	0.378													23	75	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23285254	23285258	+	RNA	DEL	TCCCT	TCCCT	-			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr15:23285254_23285258delTCCCT	ENST00000560464.1	-	0	5097																											CTTTCTTCTCtcccttcccttccct	0.478													5	1	---	---	---	---					
SLC6A10P	386757	broad.mit.edu	37	16	32890596	32890596	+	RNA	DEL	C	C	-			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr16:32890596delC	ENST00000330048.5	-	0	3202					NR_003083.2																						CATGGCCTCACCCCACCACGG	0.577													2	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7577104	7577105	+	Frame_Shift_Ins	INS	-	-	GGACAGGC			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:7577104_7577105insGGACAGGC	ENST00000420246.2	-	8	965_966	c.833_834insGCCTGTCC	c.(832-834)cctfs	p.-278fs	TP53_ENST00000359597.4_Frame_Shift_Ins_p.-278fs|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Frame_Shift_Ins_p.-278fs|TP53_ENST00000269305.4_Frame_Shift_Ins_p.-278fs|TP53_ENST00000445888.2_Frame_Shift_Ins_p.-278fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P278L(61)|p.P278R(30)|p.P278H(13)|p.0?(8)|p.P278F(3)|p.?(2)|p.P278fs*67(2)|p.R280fs*65(2)|p.G279fs*27(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.F270_D281del12(1)|p.V274_P278del(1)|p.S269fs*21(1)|p.P278_G279insXXXXX(1)|p.P278P(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTCTCTCCCAGGACAGGCACA	0.554		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	22	---	---	---	---					
RP11-160E2.17	0	broad.mit.edu	37	17	18988562	18988562	+	RNA	DEL	T	T	-			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:18988562delT	ENST00000442355.2	+	0	272																											CTGATGTGTGTTTTTTTTTTT	0.279													2	4	---	---	---	---					
TBC1D3P2	440452	broad.mit.edu	37	17	60347260	60347260	+	RNA	DEL	T	T	-	rs71816198		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:60347260delT	ENST00000581291.1	-	0	581																				breast(2)|kidney(1)|lung(2)	5						CTCTGAATGATTTTTTTTTTT	0.448													3	5	---	---	---	---					
MBD1	4152	broad.mit.edu	37	18	47802039	47802039	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:47802039delG	ENST00000591416.1	-	8	1154	c.723delC	c.(721-723)cccfs	p.P241fs	MBD1_ENST00000585595.1_Frame_Shift_Del_p.P241fs|MBD1_ENST00000587605.1_Frame_Shift_Del_p.P241fs|MBD1_ENST00000457839.2_Frame_Shift_Del_p.P241fs|MBD1_ENST00000382948.5_Frame_Shift_Del_p.P241fs|MBD1_ENST00000269471.5_Frame_Shift_Del_p.P241fs|MBD1_ENST00000588937.1_Frame_Shift_Del_p.P241fs|MBD1_ENST00000590208.1_Frame_Shift_Del_p.P241fs|MBD1_ENST00000347968.3_Frame_Shift_Del_p.P241fs|MBD1_ENST00000269468.5_Frame_Shift_Del_p.P241fs|MBD1_ENST00000585672.1_Frame_Shift_Del_p.P192fs|MBD1_ENST00000591535.1_Frame_Shift_Del_p.P241fs|MBD1_ENST00000398488.1_Frame_Shift_Del_p.P241fs|MBD1_ENST00000398495.2_Frame_Shift_Del_p.P241fs|MBD1_ENST00000424334.2_Frame_Shift_Del_p.P267fs|MBD1_ENST00000339998.6_Frame_Shift_Del_p.P241fs|MBD1_ENST00000436910.1_Frame_Shift_Del_p.P241fs|MBD1_ENST00000349085.2_Frame_Shift_Del_p.P241fs|MBD1_ENST00000398493.1_Frame_Shift_Del_p.P241fs|MBD1_ENST00000353909.3_Frame_Shift_Del_p.P192fs			Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1	241					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						GAAGGCAGATGGGGCAATGGC	0.637													8	48	---	---	---	---					
ALKBH6	84964	broad.mit.edu	37	19	36505121	36505124	+	Frame_Shift_Del	DEL	CCCC	CCCC	-			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:36505121_36505124delCCCC	ENST00000378875.3	-	1	17_20	c.12_15delGGGG	c.(10-15)agggggfs	p.RG4fs	ALKBH6_ENST00000495116.2_5'UTR|ALKBH6_ENST00000252984.7_5'UTR|AC002116.8_ENST00000473572.2_RNA|ALKBH6_ENST00000486389.1_5'UTR|ALKBH6_ENST00000485128.1_5'UTR	NM_032878.3|NM_198867.1	NP_116267.3|NP_942567.1	Q3KRA9	ALKB6_HUMAN	alkB, alkylation repair homolog 6 (E. coli)	0						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|skin(1)	9	all_lung(56;1.35e-06)|Lung NSC(56;2.15e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			ACATCCCCATCCCCCTCCCAGCCA	0.593													22	71	---	---	---	---					
