Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MOCS3	27304	broad.mit.edu	37	20	49575532	49575532	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:49575532G>A	ENST00000244051.1	+	1	170	c.153G>A	c.(151-153)ccG>ccA	p.P51P		NM_014484.3	NP_055299.1	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	51					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	24						CGCTGCCGCCGAAGGCCGCTC	0.652000													6	122					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42196160	42196160	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:42196160C>T	ENST00000541110.1	-	18	4154	c.3586G>A	c.(3586-3588)Gag>Aag	p.E1196K	TRERF1_ENST00000340840.2_Missense_Mutation_p.E1105K|TRERF1_ENST00000354325.2_Missense_Mutation_p.E1093K|TRERF1_ENST00000372922.4_Missense_Mutation_p.E1176K|TRERF1_ENST00000372917.4_Missense_Mutation_p.E1105K			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1176	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ACTTCAGCCTCTTCCATGACA	0.532000													12	148					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25283562	25283562	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:25283562C>T	ENST00000218548.6	+	18	2905	c.2572C>T	c.(2572-2574)Cgc>Tgc	p.R858C	ATP12A_ENST00000381946.3_Missense_Mutation_p.R852C	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	852					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CAGGAAGCCTCGCCACAAGAA	0.557000													12	58					0	0	1	0	0
CPEB1	64506	broad.mit.edu	37	15	83295967	83295967	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:83295967C>T	ENST00000563800.1	-	2	1973	c.248G>A	c.(247-249)cGa>cAa	p.R83Q	CPEB1_ENST00000562019.1_Missense_Mutation_p.R56Q|CPEB1_ENST00000450751.2_5'UTR|CPEB1_ENST00000568757.1_5'UTR|CPEB1_ENST00000568128.1_Missense_Mutation_p.R56Q			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	56					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			ATGAATTCCTCGGTTTATAGG	0.403000													25	76					0	0	1	0	0
ZSCAN9	7746	broad.mit.edu	37	6	28200360	28200360	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:28200360G>A	ENST00000425468.2	+	5	907	c.742G>A	c.(742-744)Gac>Aac	p.D248N	ZSCAN9_ENST00000252207.5_Missense_Mutation_p.D197N|ZSCAN9_ENST00000531979.1_Missense_Mutation_p.D197N	NM_001199479.1	NP_001186408.1			zinc finger and SCAN domain containing 9																		CAAGACTGAGGACAGAGAGTT	0.423000													6	77					0	0	1	0	0
DENND1A	57706	broad.mit.edu	37	9	126143804	126143804	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:126143804C>T	ENST00000373624.2	-	22	3138	c.2937G>A	c.(2935-2937)caG>caA	p.Q979Q	DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000394219.3_Silent_p.Q990Q|DENND1A_ENST00000542603.1_Silent_p.Q764Q	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	979	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						GCTTGGTTTTCTGTAACAAAT	0.647000													9	39					0	0	1	0	0
C16orf71	146562	broad.mit.edu	37	16	4797521	4797521	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:4797521G>A	ENST00000299320.5	+	9	1936	c.1458G>A	c.(1456-1458)caG>caA	p.Q486Q	RP11-127I20.7_ENST00000588099.1_RNA|C16orf71_ENST00000590191.1_Silent_p.Q503Q	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	486										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						CCAAGGGGCAGAGCGCCCAGG	0.667000													7	20					0	0	1	0	0
SCAF4	57466	broad.mit.edu	37	21	33069036	33069036	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:33069036C>T	ENST00000286835.7	-	8	1187	c.805G>A	c.(805-807)Gat>Aat	p.D269N	SCAF4_ENST00000434667.3_Missense_Mutation_p.D254N|SCAF4_ENST00000399804.1_Missense_Mutation_p.D269N	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	269						nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						TCTGGCTCATCATCATAGTCA	0.423000													17	95					0	0	1	0	0
CLCA3P	9629	broad.mit.edu	37	1	87102530	87102530	+	RNA	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:87102530G>C	ENST00000456587.1	-	0	294				CLCA3P_ENST00000466454.1_RNA																							GGGAGTATTTGATGAGTATAA	0.363000													5	98					0	0	1	0	0
C4BPA	722	broad.mit.edu	37	1	207314612	207314612	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:207314612C>T	ENST00000367070.3	+	10	1629	c.1435C>T	c.(1435-1437)Caa>Taa	p.Q479*		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	479	Sushi 7.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						TCCAGCCCCTCAATGTAAAGG	0.463000													19	86					0	0	1	0	0
NUDT6	11162	broad.mit.edu	37	4	123843692	123843692	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:123843692C>G	ENST00000304430.5	-	1	69	c.36G>C	c.(34-36)gcG>gcC	p.A12A	NUDT6_ENST00000339154.2_Intron	NM_007083.4	NP_009014.2	P53370	NUDT6_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 6	12						mitochondrion|nucleus	growth factor activity|hydrolase activity			endometrium(2)|lung(1)|prostate(1)|skin(1)|stomach(1)	6						GGGCAAGCATCGCGCGCCAGC	0.692000													7	20					0	0	1	0	0
TFAP2E	339488	broad.mit.edu	37	1	36056363	36056363	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:36056363C>A	ENST00000373235.3	+	6	1241	c.1033C>A	c.(1033-1035)Ctg>Atg	p.L345M		NM_178548.3	NP_848643.2	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)	345	H-S-H (helix-span-helix), dimerization.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)	2		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CAAGAGCATGCTGCTGGCTGC	0.612000													3	18					0.00024832	0.000254589	1	1	0
SCAPER	49855	broad.mit.edu	37	15	76673758	76673758	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:76673758G>T	ENST00000538941.2	-	28	3867	c.2928C>A	c.(2926-2928)ttC>ttA	p.F976L	SCAPER_ENST00000324767.7_Missense_Mutation_p.F1222L|SCAPER_ENST00000563290.1_Missense_Mutation_p.F1222L	NM_001145923.1	NP_001139395.1	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1221						endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						AGCTGTTGAAGAAACGTAAAC	0.428000													8	34					2.17888e-05	2.26244e-05	1	1	0
DDX54	79039	broad.mit.edu	37	12	113599123	113599123	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:113599123C>A	ENST00000314045.7	-	19	2392	c.2365G>T	c.(2365-2367)Gac>Tac	p.D789Y	DDX54_ENST00000306014.5_Missense_Mutation_p.D789Y|DDX54_ENST00000549271.1_5'UTR	NM_001111322.1	NP_001104792.1	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	789					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CCTCGCCGGTCAGATGCCCCT	0.577000													15	37					9.16793e-09	9.69863e-09	1	1	0
MAVS	57506	broad.mit.edu	37	20	3842137	3842137	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3842137G>C	ENST00000428216.2	+	4	579	c.451G>C	c.(451-453)Gag>Cag	p.E151Q	MAVS_ENST00000416600.2_Missense_Mutation_p.E10Q|MAVS_ENST00000358134.6_Intron	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein	151	Pro-rich.				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						CCAGGCGCCAGAGTCCCCAGG	0.592000													6	65					0	0	1	0	0
USP41	373856	broad.mit.edu	37	22	20723725	20723725	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:20723725C>T	ENST00000454608.2	-	8	620	c.621G>A	c.(619-621)aaG>aaA	p.K207K	USP41_ENST00000486536.2_5'UTR					ubiquitin specific peptidase 41											endometrium(1)|kidney(1)|lung(2)|skin(1)	5						TTACCAGTGTCTTCAGGGGCT	0.423000													8	51					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9783920	9783920	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:9783920C>T	ENST00000304374.2	+	1	663	c.267C>T	c.(265-267)ttC>ttT	p.F89F		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	89					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CAGACCTTTTCGTGGCGCTGC	0.632000													19	17					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9783854	9783854	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:9783854G>A	ENST00000304374.2	+	1	597	c.201G>A	c.(199-201)cgG>cgA	p.R67R		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	67					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CCATCGTGCGGAGCCGCCACC	0.647000													10	8					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158450384	158450384	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:158450384C>T	ENST00000368152.1	+	1	717	c.717C>T	c.(715-717)ctC>ctT	p.L239L	RP11-144L1.4_ENST00000426251.1_RNA|RP11-144L1.4_ENST00000419738.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	239			L -> F (in dbSNP:rs1418843).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					TTTCTTATCTCTGCATTCTGA	0.428000													14	118					0	0	1	0	0
FAHD2CP	729234	broad.mit.edu	37	2	96686904	96686904	+	RNA	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:96686904G>A	ENST00000607780.1	+	0	886																											GCTGTCGAGTGAATGGGGAAG	0.488000													13	91					0	0	1	0	0
ACLY	47	broad.mit.edu	37	17	40028327	40028327	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:40028327C>T	ENST00000352035.2	-	24	2881	c.2751G>A	c.(2749-2751)ggG>ggA	p.G917G	ACLY_ENST00000590151.1_Silent_p.G917G|ACLY_ENST00000537919.1_Silent_p.G646G|ACLY_ENST00000353196.1_Silent_p.G907G|ACLY_ENST00000393896.2_Silent_p.G907G	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase	917				AGKD -> TAVE (in Ref. 1; CAA45614).	ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				CCAGGTCTTTCCCAGCTCGCG	0.567000													4	37					0	0	1	0	0
VIPAS39	63894	broad.mit.edu	37	14	77916080	77916080	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:77916080C>T	ENST00000553888.1	-	5	869	c.359G>A	c.(358-360)gGa>gAa	p.G120E	VIPAS39_ENST00000448935.2_Missense_Mutation_p.G71E|VIPAS39_ENST00000556412.1_Missense_Mutation_p.G146E|VIPAS39_ENST00000327028.4_Intron|VIPAS39_ENST00000343765.2_Missense_Mutation_p.G120E|VIPAS39_ENST00000557658.1_Missense_Mutation_p.G120E	NM_001193314.1|NM_001193317.1|NM_022067.3	NP_001180243.1|NP_001180246.1|NP_071350.2			VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog																		CTGGAAACTTCCAGGTCTAGT	0.443000													44	72					0	0	1	0	0
NEIL2	252969	broad.mit.edu	37	8	11637344	11637344	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:11637344G>C	ENST00000284503.6	+	3	975	c.376G>C	c.(376-378)Gat>Cat	p.D126H	NEIL2_ENST00000528323.1_Intron|NEIL2_ENST00000403422.3_Missense_Mutation_p.D65H|NEIL2_ENST00000455213.2_Missense_Mutation_p.D126H|NEIL2_ENST00000436750.3_Missense_Mutation_p.D126H	NM_145043.2	NP_659480.1	Q969S2	NEIL2_HUMAN	nei endonuclease VIII-like 2 (E. coli)	126					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		CCCTGCAGGAGATGCTGGGAG	0.577000								Base excision repair (BER), DNA glycosylases					16	83					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3640791	3640791	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:3640791C>G	ENST00000294008.3	-	12	3488	c.2848G>C	c.(2848-2850)Gag>Cag	p.E950Q		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	950	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						AGCGCCTCCTCTGGCGCCTCC	0.657000								Direct reversal of damage					13	54					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57489208	57489208	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:57489208G>A	ENST00000371236.2	-	11	1154	c.891C>T	c.(889-891)ccC>ccT	p.P297P	DAB1_ENST00000414851.2_Silent_p.P279P|DAB1_ENST00000371231.1_Silent_p.P330P|DAB1_ENST00000439789.2_Silent_p.P211P|DAB1_ENST00000371234.4_Silent_p.P297P|DAB1_ENST00000420954.2_Silent_p.P295P|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	330					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GCTTACCTGAGGGTACAGCAG	0.493000													7	11					0	0	1	0	0
GPR173	54328	broad.mit.edu	37	X	53106308	53106308	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:53106308C>T	ENST00000332582.4	+	2	996	c.505C>T	c.(505-507)Cgg>Tgg	p.R169W		NM_018969.5	NP_061842.1	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	169						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)	16						CAAGTTTATTCGGGAGGAGGA	0.562000													6	12					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597320	136597320	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:136597320C>G	ENST00000531224.1	-	5	1595	c.1343G>C	c.(1342-1344)aGa>aCa	p.R448T	BCLAF1_ENST00000392348.2_Missense_Mutation_p.R446T|BCLAF1_ENST00000527759.1_Missense_Mutation_p.R446T|BCLAF1_ENST00000353331.4_Missense_Mutation_p.R446T|BCLAF1_ENST00000527536.1_Missense_Mutation_p.R448T|BCLAF1_ENST00000530767.1_Intron	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	448					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ATCACTTTCTCTATTGCCTTT	0.388000													12	240					0	0	1	0	0
MAVS	57506	broad.mit.edu	37	20	3838402	3838402	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3838402G>A	ENST00000428216.2	+	3	366	c.238G>A	c.(238-240)Gag>Aag	p.E80K	MAVS_ENST00000416600.2_Intron|MAVS_ENST00000358134.6_Missense_Mutation_p.E80K	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein	80					activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						GAGGGGCTGTGAGCTAGTTGA	0.632000													13	109					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57187752	57187752	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:57187752C>T	ENST00000331162.4	-	5	1640	c.1370G>A	c.(1369-1371)aGa>aAa	p.R457K		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			AGTATGAATTCTCTTGTGGTC	0.433000													8	133					0	0	1	0	0
ERF	2077	broad.mit.edu	37	19	42753748	42753748	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:42753748G>A	ENST00000222329.4	-	4	673	c.516C>T	c.(514-516)ctC>ctT	p.L172L	AC006486.9_ENST00000594664.1_Intron|ERF_ENST00000440177.2_Silent_p.L97L	NM_006494.2	NP_006485.2	P50548	ERF_HUMAN	Ets2 repressor factor	172					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	17		Prostate(69;0.00682)				CAGCCGAGAAGAGGGAAGATG	0.657000													4	61					0	0	1	0	0
GABRA5	2558	broad.mit.edu	37	15	27193135	27193135	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:27193135A>G	ENST00000335625.5	+	11	2032	c.1144A>G	c.(1144-1146)Atg>Gtg	p.M382V	GABRA5_ENST00000400081.3_Missense_Mutation_p.M382V|GABRA5_ENST00000355395.5_Missense_Mutation_p.M382V	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	382					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AACTGGGAAGATGTCTCACCC	0.433000													4	5					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31354887	31354887	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:31354887G>A	ENST00000542188.1	-	8	1348	c.1035C>T	c.(1033-1035)ctC>ctT	p.L345L	TRPM1_ENST00000397795.2_Silent_p.L306L|TRPM1_ENST00000256552.6_Silent_p.L328L	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	306					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GCTGCTCCCTGAGGGACTCAT	0.333000													5	84					0	0	1	0	0
ACTR8	93973	broad.mit.edu	37	3	53902769	53902769	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:53902769C>G	ENST00000335754.3	-	13	1952	c.1852G>C	c.(1852-1854)Gag>Cag	p.E618Q	ACTR8_ENST00000488802.1_5'UTR|ACTR8_ENST00000482349.1_Missense_Mutation_p.E507Q|ACTR8_ENST00000231909.7_Missense_Mutation_p.E323Q	NM_022899.4	NP_075050.3	Q9H981	ARP8_HUMAN	ARP8 actin-related protein 8 homolog (yeast)	618					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		GCAGCCCGCTCTCGTAACATG	0.478000													9	44					0	0	1	0	0
SPIN2A	54466	broad.mit.edu	37	X	57162619	57162619	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:57162619C>G	ENST00000374908.1	-	1	811	c.412G>C	c.(412-414)Gag>Cag	p.E138Q	SPIN2A_ENST00000374906.3_Missense_Mutation_p.E138Q			Q99865	SPI2A_HUMAN	spindlin family, member 2A	138					cell cycle|gamete generation					breast(1)|kidney(1)|ovary(1)	3						TGCTCTCCCTCAAACATGTGT	0.418000													38	103					0	0	1	0	0
DKKL1	27120	broad.mit.edu	37	19	49867963	49867963	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:49867963C>G	ENST00000221498.2	+	2	540	c.135C>G	c.(133-135)ctC>ctG	p.L45L	DKKL1_ENST00000594268.1_Intron	NM_014419.3	NP_055234.1	Q9UK85	DKKL1_HUMAN	dickkopf-like 1	45					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity			large_intestine(2)|upper_aerodigestive_tract(1)	3		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)		CCTTGGGTCTCACAGGCCTCC	0.587000													4	78					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21233505	21233505	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:21233505C>T	ENST00000233242.1	-	26	6362	c.6235G>A	c.(6235-6237)Gaa>Aaa	p.E2079K		NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	2079	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCAAAATATTCTTGCAAGGTC	0.343000													22	79					0	0	1	0	0
INSL5	10022	broad.mit.edu	37	1	67266883	67266883	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:67266883G>C	ENST00000304526.2	-	1	56	c.22C>G	c.(22-24)Ctg>Gtg	p.L8V		NM_005478.4	NP_005469.2	Q9Y5Q6	INSL5_HUMAN	insulin-like 5	8						extracellular region	hormone activity			breast(2)|endometrium(1)|lung(5)	8						AATAAAAACAGAGTGAAAATG	0.418000													4	32					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67404900	67404900	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:67404900G>C	ENST00000329956.6	+	9	1268	c.1249G>C	c.(1249-1251)Gag>Cag	p.E417Q	LRRC36_ENST00000290940.7_Missense_Mutation_p.E149Q|LRRC36_ENST00000435835.3_Missense_Mutation_p.E296Q|LRRC36_ENST00000563189.1_Missense_Mutation_p.E296Q|LRRC36_ENST00000541146.1_5'UTR	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	417										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		TGTCAATGTAGAGCAACAATT	0.493000													7	96					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89800365	89800365	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:89800365C>T	ENST00000289816.5	+	9	1480	c.1168C>T	c.(1168-1170)Cgg>Tgg	p.R390W	ZNF276_ENST00000446326.2_Missense_Mutation_p.R251W|ZNF276_ENST00000443381.2_Missense_Mutation_p.R465W|ZNF276_ENST00000568064.1_Missense_Mutation_p.R373W	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R390W(1)		cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GGTCCGGGAGCGGCCCTGCCC	0.627000													13	19					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93821974	93821974	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:93821974C>G	ENST00000315765.9	+	12	2142	c.2134C>G	c.(2134-2136)Cag>Gag	p.Q712E		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	712	Plastocyanin-like 4.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AGGCATGGGTCAGATCTATGA	0.502000													17	35					0	0	1	0	0
EVC	2121	broad.mit.edu	37	4	5749989	5749989	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:5749989G>T	ENST00000382674.2	+	8	1238	c.1054G>T	c.(1054-1056)Gca>Tca	p.A352S	EVC_ENST00000509451.1_Missense_Mutation_p.A352S|EVC_ENST00000264956.6_Missense_Mutation_p.A352S			P57679	EVC_HUMAN	Ellis van Creveld syndrome	352					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				AAGAATGATTGCAGCCGAAGG	0.488000													25	11					1.42536e-11	1.53226e-11	1	1	0
KLHL41	10324	broad.mit.edu	37	2	170366331	170366331	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:170366331C>T	ENST00000284669.1	+	1	120	c.43C>T	c.(43-45)Caa>Taa	p.Q15*	RP11-724O16.1_ENST00000513963.1_Intron|BBS5_ENST00000554017.1_Intron	NM_006063.2	NP_006054.2			kelch-like family member 41																		GCGGCTTTACCAATCCACCCT	0.488000													47	102					0	0	1	0	0
HTATSF1	27336	broad.mit.edu	37	X	135593696	135593696	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:135593696G>T	ENST00000535601.1	+	10	2214	c.1792G>T	c.(1792-1794)Gaa>Taa	p.E598*	HTATSF1_ENST00000218364.4_Nonsense_Mutation_p.E598*	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	598	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					AAATGACTCTGAAAACTCCGA	0.388000													29	50					8.58068e-18	9.34796e-18	1	1	0
IL31RA	133396	broad.mit.edu	37	5	55178994	55178994	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:55178994C>T	ENST00000396834.1	+	7	1016	c.520C>T	c.(520-522)Cga>Tga	p.R174*	IL31RA_ENST00000490985.1_Nonsense_Mutation_p.R51*|IL31RA_ENST00000297015.3_Nonsense_Mutation_p.R51*|IL31RA_ENST00000359040.5_Nonsense_Mutation_p.R193*|IL31RA_ENST00000447346.2_Nonsense_Mutation_p.R193*|IL31RA_ENST00000396836.2_Nonsense_Mutation_p.R193*|IL31RA_ENST00000354961.4_Nonsense_Mutation_p.R174*	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	161	Fibronectin type-III 2.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				ATACACACTTCGATTCAGGAC	0.383000													14	31					0	0	1	0	0
TNPO1	3842	broad.mit.edu	37	5	72192888	72192888	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:72192888G>C	ENST00000337273.5	+	20	2674	c.2248G>C	c.(2248-2250)Gag>Cag	p.E750Q	TNPO1_ENST00000506351.2_Missense_Mutation_p.E742Q|TNPO1_ENST00000523768.1_Missense_Mutation_p.E700Q|TNPO1_ENST00000454282.1_Missense_Mutation_p.E700Q	NM_002270.3	NP_002261.3	Q92973	TNPO1_HUMAN	transportin 1	750					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(6)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	36		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		TCTAGGTATAGAGATGCAGCC	0.343000													16	31					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32915264	32915264	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:32915264G>A	ENST00000544455.1	+	11	6999	c.6772G>A	c.(6772-6774)Gaa>Aaa	p.E2258K	BRCA2_ENST00000380152.3_Missense_Mutation_p.E2258K	NM_000059.3	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2258					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TACATGTCCCGAAAATGAGGA	0.378000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			18	179					0	0	1	0	0
GGT5	2687	broad.mit.edu	37	22	24622208	24622208	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:24622208C>T	ENST00000327365.4	-	8	1481	c.1065G>A	c.(1063-1065)gaG>gaA	p.E355E	GGT5_ENST00000418439.2_Silent_p.E278E|GGT5_ENST00000263112.7_Silent_p.E323E|GGT5_ENST00000398292.3_Silent_p.E355E	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	355					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						GGGCCAGGGTCTCCCCCAGCA	0.677000													6	27					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141533803	141533803	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:141533803C>T	ENST00000389484.3	-	33	6335	c.5364G>A	c.(5362-5364)aaG>aaA	p.K1788K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1788					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACCACAGTTTCTTATCTAGAA	0.343000										TSP Lung(27;0.18)			8	34					0	0	1	0	0
TPCN2	219931	broad.mit.edu	37	11	68838873	68838873	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:68838873C>T	ENST00000294309.3	+	10	1046	c.945C>T	c.(943-945)ttC>ttT	p.F315F	TPCN2_ENST00000542467.1_Silent_p.F315F|TPCN2_ENST00000442692.2_3'UTR	NM_139075.3	NP_620714.2	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	315					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	32			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ACAGTCAGTTCCGGGGCTACC	0.597000													3	11					0	0	1	0	0
XPO5	57510	broad.mit.edu	37	6	43528732	43528732	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43528732C>G	ENST00000265351.7	-	10	1234	c.1024G>C	c.(1024-1026)Gat>Cat	p.D342H		NM_020750.2	NP_065801.1	Q9HAV4	XPO5_HUMAN	exportin 5	342					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(4)|lung(10)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	34	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			GTTTCTACATCAGAATCTGCA	0.368000													14	67					0	0	1	0	0
GPR37L1	9283	broad.mit.edu	37	1	202097339	202097339	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:202097339C>T	ENST00000367282.5	+	2	1207	c.1101C>T	c.(1099-1101)gtC>gtT	p.V367V		NM_004767.3	NP_004758.3	O60883	ETBR2_HUMAN	G protein-coupled receptor 37 like 1							integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	18						TGACCGTGGTCTACGCCTTCT	0.647000													9	113					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39893741	39893741	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:39893741G>A	ENST00000564288.1	+	63	17362	c.16585G>A	c.(16585-16587)Gaa>Aaa	p.E5529K	MACF1_ENST00000567887.1_Missense_Mutation_p.E5566K|MACF1_ENST00000361689.2_Missense_Mutation_p.E3467K|MACF1_ENST00000372915.3_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000317713.7_Missense_Mutation_p.E3467K|MACF1_ENST00000545844.1_Missense_Mutation_p.E3467K|MACF1_ENST00000289893.4_Missense_Mutation_p.E3969K			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5534					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGTGCTGTCAGAAAAGATAGA	0.498000													5	66					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47569810	47569810	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:47569810C>T	ENST00000253048.5	-	15	3752	c.3715G>A	c.(3715-3717)Gag>Aag	p.E1239K	ZC3H4_ENST00000594019.1_5'UTR	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	1239							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GGGGCACCCTCGGGGGGTGGG	0.701000													4	7					0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12502718	12502718	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:12502718C>G	ENST00000419318.1	-	4	1147	c.398G>C	c.(397-399)gGa>gCa	p.G133A	CTD-3105H18.14_ENST00000435033.1_Intron|ZNF799_ENST00000430385.3_Missense_Mutation_p.G165A			Q96GE5	ZN799_HUMAN	zinc finger protein 799	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						TGGTTTCTTTCCAGTGTGAAG	0.428000													6	100					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102740934	102740934	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:102740934G>C	ENST00000210633.3	+	13	1731	c.1653G>C	c.(1651-1653)ctG>ctC	p.L551L	SEMA4G_ENST00000517724.1_Silent_p.L551L|MRPL43_ENST00000318325.2_Intron|MRPL43_ENST00000370241.3_Intron|MRPL43_ENST00000370242.4_Intron|SEMA4G_ENST00000370250.4_Silent_p.L546L|RP11-108L7.4_ENST00000447344.1_RNA			Q9NTN9	SEM4G_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	546	PSI.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		GGACAGCACTGATACAGGACA	0.473000													5	35					0	0	1	0	0
SEPT10	151011	broad.mit.edu	37	2	110332202	110332202	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:110332202G>C	ENST00000356688.4	-	5	871	c.556C>G	c.(556-558)Ctg>Gtg	p.L186V	SEPT10_ENST00000437928.1_Missense_Mutation_p.L171V|SEPT10_ENST00000545389.1_Intron|SEPT10_ENST00000397712.2_Missense_Mutation_p.L186V|SEPT10_ENST00000334001.6_Missense_Mutation_p.L53V|SEPT10_ENST00000397714.2_Missense_Mutation_p.L163V|SEPT10_ENST00000415095.1_Missense_Mutation_p.L186V			Q9P0V9	SEP10_HUMAN	septin 10	186					cell cycle|cell division	septin complex	GTP binding			breast(2)|endometrium(3)|large_intestine(4)|lung(8)|prostate(1)	18						AGTGTCTTCAGAGAGTGGCCT	0.393000													16	66					0	0	1	0	0
GLI4	2738	broad.mit.edu	37	8	144358969	144358969	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:144358969G>C	ENST00000340042.1	+	4	1211	c.1126G>C	c.(1126-1128)Gag>Cag	p.E376Q	GLI4_ENST00000523522.1_Missense_Mutation_p.E376Q|GLI4_ENST00000523812.1_3'UTR	NM_138465.3	NP_612474.1	P10075	GLI4_HUMAN	GLI family zinc finger 4	376						nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(1)|lung(5)	9	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GCACTACCGCGAGTAGCCGGG	0.736000													3	7					0	0	1	0	0
DPRX	503834	broad.mit.edu	37	19	54140199	54140199	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54140199C>G	ENST00000376650.1	+	3	584	c.533C>G	c.(532-534)tCt>tGt	p.S178C		NM_001012728.1	NP_001012746.1	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	178						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|large_intestine(1)|lung(7)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		AGCTTCCATTCTGGCTCTCCT	0.438000													9	176					0	0	1	0	0
NARFL	64428	broad.mit.edu	37	16	783368	783368	+	Silent	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:783368C>A	ENST00000540986.1	-	6	1882	c.447G>T	c.(445-447)ctG>ctT	p.L149L	NARFL_ENST00000301694.5_3'UTR|HAGHL_ENST00000569604.1_Intron|NARFL_ENST00000568545.1_Silent_p.L149L|NARFL_ENST00000251588.2_Silent_p.L251L|NARFL_ENST00000562862.1_5'UTR			Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	251					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				TGGAGGCTTCCAGCTTTTTGT	0.557000													4	51					0.00024832	0.000254589	1	1	0
TSSK1B	83942	broad.mit.edu	37	5	112770257	112770257	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:112770257C>T	ENST00000390666.3	-	1	471	c.280G>A	c.(280-282)Gtc>Atc	p.V94I	MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000383058.4_RNA|CTD-2201G3.1_ENST00000416046.2_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	94	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TCGCCCTGGACCGCGAGCTCC	0.512000													11	24					0	0	1	0	0
C14orf93	60686	broad.mit.edu	37	14	23456450	23456450	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:23456450C>G	ENST00000299088.6	-	7	2020	c.1591G>C	c.(1591-1593)Gaa>Caa	p.E531Q	C14orf93_ENST00000397379.3_Missense_Mutation_p.E531Q|C14orf93_ENST00000397377.1_Missense_Mutation_p.E351Q|C14orf93_ENST00000406429.2_Missense_Mutation_p.E491Q|RP11-298I3.4_ENST00000556503.1_RNA|RP11-298I3.4_ENST00000555294.1_RNA|C14orf93_ENST00000397382.4_Missense_Mutation_p.E531Q|C14orf93_ENST00000341470.4_Missense_Mutation_p.E491Q|RP11-298I3.4_ENST00000557615.1_RNA	NM_001130708.1|NM_021944.2	NP_001124180.1|NP_068763.2	Q9H972	CN093_HUMAN	chromosome 14 open reading frame 93	531						extracellular region				kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	17	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		ACCTTGATTTCAATGAATGAG	0.483000											OREG0022593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	35					0	0	1	0	0
CCDC102B	79839	broad.mit.edu	37	18	66564576	66564576	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:66564576G>A	ENST00000360242.5	+	6	1291	c.1174G>A	c.(1174-1176)Gag>Aag	p.E392K	CCDC102B_ENST00000358653.5_Missense_Mutation_p.E392K|CCDC102B_ENST00000319445.6_Missense_Mutation_p.E392K|CCDC102B_ENST00000577772.1_3'UTR|CCDC102B_ENST00000584156.1_Missense_Mutation_p.E392K	NM_024781.2	NP_079057	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	392										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AGAAATGGAAGAGCTTTTGGA	0.393000													12	83					0	0	1	0	0
ITGB1	3688	broad.mit.edu	37	10	33201009	33201009	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:33201009C>G	ENST00000396033.2	-	12	1648	c.1513G>C	c.(1513-1515)Gat>Cat	p.D505H	ITGB1_ENST00000302278.3_Missense_Mutation_p.D505H|ITGB1_ENST00000374956.4_Missense_Mutation_p.D505H|ITGB1_ENST00000423113.1_Missense_Mutation_p.D505H	NM_133376.2	NP_596867.1	P05556	ITB1_HUMAN	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	505	Cysteine-rich tandem repeats.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TTAACTTCATCTGTGCTGCAT	0.413000													13	46					0	0	1	0	0
IGHV3-33	28434	broad.mit.edu	37	14	106815956	106815956	+	RNA	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:106815956G>A	ENST00000390615.2	-	0	196																											CTGCACAGGAGAGTCTCAGGG	0.587000													15	48					0	0	1	0	0
PTGER3	5733	broad.mit.edu	37	1	71418609	71418609	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:71418609G>A	ENST00000356595.4	-	4	1448	c.1238C>T	c.(1237-1239)tCa>tTa	p.S413L	PTGER3_ENST00000370932.2_Intron|PTGER3_ENST00000351052.5_Intron|PTGER3_ENST00000354608.5_Intron|PTGER3_ENST00000460330.1_Intron|PTGER3_ENST00000370931.3_Intron|PTGER3_ENST00000414819.1_3'UTR	NM_198718.1	NP_942011.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	0					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	CTTTACTGTTGAGATTCTGGT	0.423000													8	183					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43439684	43439684	+	RNA	SNP	A	A	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:43439684A>G	ENST00000406070.2	-	0	398				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				ATTGGAATATACTGTTTCTCA	0.418000													30	585					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24896300	24896300	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:24896300G>C	ENST00000405141.1	+	8	1033	c.322G>C	c.(322-324)Gaa>Caa	p.E108Q	NCOA1_ENST00000348332.3_Missense_Mutation_p.E108Q|NCOA1_ENST00000406961.1_Missense_Mutation_p.E108Q|NCOA1_ENST00000538539.1_Missense_Mutation_p.E108Q|NCOA1_ENST00000395856.3_Missense_Mutation_p.E108Q|NCOA1_ENST00000288599.5_Missense_Mutation_p.E108Q|NCOA1_ENST00000407230.1_5'UTR			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	108									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGTGATAGAAAAGGAATC	0.338000			T	PAX3	alveolar rhadomyosarcoma								30	105					0	0	1	0	0
DNASE1L3	1776	broad.mit.edu	37	3	58183687	58183687	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:58183687C>A	ENST00000483681.1	-	8	1146	c.565G>T	c.(565-567)Gac>Tac	p.D189Y	DNASE1L3_ENST00000394549.2_Missense_Mutation_p.D189Y|DNASE1L3_ENST00000486455.1_Missense_Mutation_p.D159Y|DNASE1L3_ENST00000318316.3_Missense_Mutation_p.D189Y			Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3	189					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(4)|lung(6)	12				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		GCATTGAAGTCACCCATGAAA	0.512000													14	30					2.32078e-09	2.46225e-09	1	1	0
DPRX	503834	broad.mit.edu	37	19	54139969	54139969	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54139969G>C	ENST00000376650.1	+	3	354	c.303G>C	c.(301-303)ctG>ctC	p.L101L		NM_001012728.1	NP_001012746.1	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	101						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|large_intestine(1)|lung(7)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		GTGTCGGCCTGAGAAATGCAG	0.527000													43	85					0	0	1	0	0
PMVK	10654	broad.mit.edu	37	1	154898934	154898934	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:154898934G>A	ENST00000368467.3	-	4	643	c.338C>T	c.(337-339)tCt>tTt	p.S113F		NM_006556.3	NP_006547.1	Q15126	PMVK_HUMAN	phosphomevalonate kinase	113					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CTGGATGTCAGACACTCTCCG	0.607000													18	20					0	0	1	0	0
BCL6B	255877	broad.mit.edu	37	17	6927018	6927018	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:6927018G>C	ENST00000293805.5	+	2	120	c.28G>C	c.(28-30)Gcg>Ccg	p.A10P	BCL6B_ENST00000572216.1_3'UTR	NM_181844.3	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B	10						nucleus	zinc ion binding			skin(1)	1						CCCGGAGGGAGCGCTGGGCTA	0.662000													16	23					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91809817	91809817	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:91809817C>G	ENST00000394232.1	+	7	1484	c.1014C>G	c.(1012-1014)tcC>tcG	p.S338S	SV2B_ENST00000330276.4_Silent_p.S338S|SV2B_ENST00000545111.2_Silent_p.S187S	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	338					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TTCAGGTTTCCAACATCAAAA	0.368000													14	41					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97096663	97096663	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:97096663G>A	ENST00000371247.2	-	30	3443	c.3254C>T	c.(3253-3255)tCa>tTa	p.S1085L	SORBS1_ENST00000371249.2_Intron|SORBS1_ENST00000371246.2_Intron|SORBS1_ENST00000371227.4_Missense_Mutation_p.S1039L|SORBS1_ENST00000353505.5_Intron|SORBS1_ENST00000393949.1_Intron|SORBS1_ENST00000306402.6_Intron|SORBS1_ENST00000277982.5_Intron|SORBS1_ENST00000371241.1_Intron|SORBS1_ENST00000607232.1_Intron|SORBS1_ENST00000361941.3_Missense_Mutation_p.S1085L|SORBS1_ENST00000354106.3_Intron|SORBS1_ENST00000347291.4_Intron|SORBS1_ENST00000371239.1_Intron|SORBS1_ENST00000371245.3_Intron			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	1085					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GTGGATGCCTGAAGATGGCGT	0.562000													5	27					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	970701	970701	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:970701G>A	ENST00000379370.2	+	3	558	c.508G>A	c.(508-510)Gat>Aat	p.D170N	AGRN_ENST00000477585.1_3'UTR	NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	170					axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GACGCCTCCTGATGGTGAGTA	0.597000													22	113					0	0	1	0	0
DRG1	4733	broad.mit.edu	37	22	31796663	31796663	+	Missense_Mutation	SNP	C	C	T	rs28369552		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:31796663C>T	ENST00000331457.4	+	2	261	c.100C>T	c.(100-102)Cgt>Tgt	p.R34C	DRG1_ENST00000433341.1_3'UTR	NM_004147.3	NP_004138.1	Q9Y295	DRG1_HUMAN	developmentally regulated GTP binding protein 1	34					multicellular organismal development|transcription, DNA-dependent	cytoplasm|intermediate filament cytoskeleton|nucleus	GTP binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|urinary_tract(1)	11						GCTTAAGGCTCGTCTTGCTAA	0.458000													33	50					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124412979	124412979	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:124412979G>A	ENST00000306842.2	-	1	596	c.572C>T	c.(571-573)tCt>tTt	p.S191F		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	191					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		ATTCATGTAAGAGCTGTTGCA	0.458000													33	51					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100385706	100385706	+	RNA	SNP	T	T	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:100385706T>A	ENST00000542585.1	+	0	7320				ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CAGGAAGTGATTACCACCGTC	0.597000													4	56					0	0	1	0	0
BRPF1	7862	broad.mit.edu	37	3	9776368	9776368	+	Silent	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:9776368C>A	ENST00000383829.2	+	2	948	c.544C>A	c.(544-546)Cgg>Agg	p.R182R	BRPF1_ENST00000302054.3_Silent_p.R182R|BRPF1_ENST00000457855.1_Silent_p.R182R|BRPF1_ENST00000433861.2_Silent_p.R182R|BRPF1_ENST00000424362.1_Silent_p.R182R	NM_001003694.1	NP_001003694.1	P55201	BRPF1_HUMAN	bromodomain and PHD finger containing, 1	182	Interaction with MYST3 and MYST4.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	49	Medulloblastoma(99;0.227)					GGTGGTCTATCGGGAGCTGGA	0.557000													30	54					1.80694e-10	1.92267e-10	1	1	0
ACLY	47	broad.mit.edu	37	17	40039486	40039486	+	Splice_Site	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:40039486C>A	ENST00000352035.2	-	20	2285		c.e20-1		ACLY_ENST00000590151.1_Splice_Site|ACLY_ENST00000537919.1_Splice_Site|ACLY_ENST00000353196.1_Splice_Site|ACLY_ENST00000393896.2_Splice_Site	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase						ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				TGCCCCCAATCTGCCAAGGAA	0.517000													26	37					1.33986e-20	1.46843e-20	1	1	0
PCDHA1	56147	broad.mit.edu	37	5	140166145	140166145	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:140166145C>T	ENST00000504120.2	+	1	270	c.270C>T	c.(268-270)atC>atT	p.I90I	PCDHA1_ENST00000394633.3_Silent_p.I90I|PCDHA1_ENST00000378133.3_Silent_p.I90I	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCTCGGATCGATCGCGAGG	0.577000													6	104					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9229990	9229990	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:9229990G>A	ENST00000318602.7	-	27	3610	c.3303C>T	c.(3301-3303)ctC>ctT	p.L1101L		NM_000014.4	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin	1101					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	TATAGGCGGAGAGGGTCACTT	0.453000													5	10					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370306	35370306	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:35370306G>A	ENST00000373347.1	-	3	947	c.679C>T	c.(679-681)Cac>Tac	p.H227Y	DLGAP3_ENST00000235180.4_Missense_Mutation_p.H227Y			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	227	Poly-His.				cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				tggtggtggtgatggtggtga	0.657000													5	70					0	0	1	0	0
MOCS3	27304	broad.mit.edu	37	20	49576560	49576560	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:49576560G>A	ENST00000244051.1	+	1	1198	c.1181G>A	c.(1180-1182)tGg>tAg	p.W394*		NM_014484.3	NP_055299.1	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	394	Rhodanese.				enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	24						GAAGCAATCTGGGAAGAGAAG	0.498000													91	135					0	0	1	0	0
MOK	5891	broad.mit.edu	37	14	102749865	102749865	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:102749865C>G	ENST00000361847.2	-	2	303	c.72G>C	c.(70-72)ctG>ctC	p.L24L	MOK_ENST00000522874.1_Silent_p.L24L|MOK_ENST00000193029.6_5'UTR|MOK_ENST00000524214.1_Silent_p.L24L	NM_014226.1	NP_055041.1	Q9UQ07	MOK_HUMAN	MOK protein kinase	24	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding										TTCCATCTCTCAGGCTTTGCA	0.358000													28	42					0	0	1	0	0
DCAF12	25853	broad.mit.edu	37	9	34088417	34088417	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:34088417C>T	ENST00000361264.4	-	9	1634	c.1293G>A	c.(1291-1293)acG>acA	p.T431T	RP11-537H15.3_ENST00000448245.1_RNA	NM_015397.3	NP_056212.1	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	431						centrosome|CUL4 RING ubiquitin ligase complex				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	11						CAAAGAGTTTCGTTCCAGACG	0.478000													8	210					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42049173	42049173	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:42049173C>T	ENST00000372584.1	-	3	2310	c.1296G>A	c.(1294-1296)ctG>ctA	p.L432L	HIVEP3_ENST00000247584.5_Silent_p.L432L|HIVEP3_ENST00000372583.1_Silent_p.L432L|HIVEP3_ENST00000429157.2_Silent_p.L432L	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	432	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGTGGCTGTCAGCATGGCGG	0.617000													15	33					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29747377	29747377	+	Missense_Mutation	SNP	C	C	T	rs147020336		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:29747377C>T	ENST00000375398.2	-	39	6993	c.6544G>A	c.(6544-6546)Gac>Aac	p.D2182N	PTCHD3P1_ENST00000446807.1_RNA|SVIL_ENST00000535393.1_Missense_Mutation_p.D1096N|SVIL_ENST00000355867.4_Missense_Mutation_p.D2182N|PTCHD3P1_ENST00000455774.1_RNA|PTCHD3P1_ENST00000445521.1_RNA|SVIL_ENST00000375400.3_Missense_Mutation_p.D1756N|PTCHD3P1_ENST00000414457.1_RNA|PTCHD3P1_ENST00000438202.1_RNA|PTCHD3P1_ENST00000413405.1_RNA|PTCHD3P1_ENST00000423223.1_RNA			O95425	SVIL_HUMAN	supervillin	2182	HP.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding	p.D2182N(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				AAGTCTTCGTCGGTGAGATAG	0.597000													5	44					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20039688	20039688	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:20039688G>A	ENST00000400230.2	-	8	573	c.529C>T	c.(529-531)Cga>Tga	p.R177*	TPTE2_ENST00000382978.1_Nonsense_Mutation_p.R137*|TPTE2_ENST00000400103.2_Nonsense_Mutation_p.R66*|TPTE2_ENST00000457266.2_Nonsense_Mutation_p.R66*|TPTE2_ENST00000382977.4_Nonsense_Mutation_p.R177*|TPTE2_ENST00000390680.2_Nonsense_Mutation_p.R100*|TPTE2_ENST00000382975.4_Nonsense_Mutation_p.R137*|TPTE2_ENST00000255310.6_Nonsense_Mutation_p.R100*			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	177						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CGTAGAAGTCGAACTAAATGT	0.313000													17	22					0	0	1	0	0
PCSK7	9159	broad.mit.edu	37	11	117094889	117094889	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:117094889C>G	ENST00000320934.3	-	8	1589	c.959G>C	c.(958-960)gGg>gCg	p.G320A		NM_004716.2	NP_004707.2	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	320	Catalytic.				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity			NS(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	16	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		AAAGATGCTCCCAAAGCCCTG	0.547000			T	IGH@	MLCLS								13	27					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146242491	146242491	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:146242491C>T	ENST00000367503.3	-	21	4230	c.3832G>A	c.(3832-3834)Gaa>Aaa	p.E1278K	SHPRH_ENST00000275233.7_Missense_Mutation_p.E1274K|SHPRH_ENST00000438092.2_Missense_Mutation_p.E1278K|SHPRH_ENST00000367505.2_Missense_Mutation_p.E1274K	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	1274					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TCTTCATCTTCTATCATCTCC	0.433000													4	25					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46930167	46930167	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:46930167C>A	ENST00000262738.3	-	1	2900	c.2901G>T	c.(2899-2901)tgG>tgT	p.W967C	CELSR1_ENST00000395964.1_Missense_Mutation_p.W967C	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	967	Cadherin 7.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CAGCCAGAGCCCAAAGGTTGT	0.597000													20	19					5.26018e-13	5.67975e-13	1	1	0
BHLHB9	80823	broad.mit.edu	37	X	102004757	102004757	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:102004757C>T	ENST00000372735.1	+	4	1419	c.834C>T	c.(832-834)atC>atT	p.I278I	BHLHB9_ENST00000361229.4_Silent_p.I278I|BHLHB9_ENST00000448867.1_Silent_p.I278I|BHLHB9_ENST00000447531.1_Silent_p.I278I|BHLHB9_ENST00000457056.1_Silent_p.I278I			Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class B, 9	278						cytoplasm|nucleus	binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CACAGCCTATCCCTGAGTGTC	0.483000													20	53					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123900853	123900853	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:123900853G>C	ENST00000373855.1	+	16	2493	c.2233G>C	c.(2233-2235)Gag>Cag	p.E745Q	CNTRL_ENST00000373847.1_Missense_Mutation_p.E193Q|CNTRL_ENST00000238341.5_Missense_Mutation_p.E745Q|CNTRL_ENST00000373850.1_Missense_Mutation_p.E193Q			Q7Z7A1	CNTRL_HUMAN	centriolin	745					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						AGCAGAACTTGAGAAGGAAAG	0.398000													13	51					0	0	1	0	0
OR5T1	390155	broad.mit.edu	37	11	56043601	56043601	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:56043601G>A	ENST00000313033.2	+	1	573	c.487G>A	c.(487-489)Gct>Act	p.A163T		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					TTCCTATGTTGCTAGCATTTT	0.428000													101	170					0	0	1	0	0
ZDHHC3	51304	broad.mit.edu	37	3	45000794	45000794	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:45000794G>A	ENST00000296127.3	-	2	408	c.135C>T	c.(133-135)atC>atT	p.I45I	ZDHHC3_ENST00000424952.2_Silent_p.I45I|ZDHHC3_ENST00000342790.4_Silent_p.I45I	NM_016598.2	NP_057682.1	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3	45						Golgi membrane|integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		TGGCACAGGCGATGCCACAGC	0.537000													14	105					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	rs28934578		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:7578406C>T	ENST00000420246.2	-	5	656	c.524G>A	c.(523-525)cGc>cAc	p.R175H	TP53_ENST00000455263.2_Missense_Mutation_p.R175H|TP53_ENST00000359597.4_Missense_Mutation_p.R175H|TP53_ENST00000413465.2_Missense_Mutation_p.R175H|TP53_ENST00000445888.2_Missense_Mutation_p.R175H|TP53_ENST00000269305.4_Missense_Mutation_p.R175H|TP53_ENST00000574684.1_5'UTR	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	175	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> C (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934578).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(847)|p.R43H(36)|p.R82H(36)|p.R175L(19)|p.0?(8)|p.R175P(6)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*5(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652000	R175H(AU565_BREAST)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(HCC1395_BREAST)|R175H(HUCCT1_BILIARY_TRACT)|R175H(KLE_ENDOMETRIUM)|R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(LS123_LARGE_INTESTINE)|R175H(NCIH196_LUNG)|R175H(RKN_OVARY)|R175H(SKBR3_BREAST)|R175H(SKUT1_SOFT_TISSUE)|R175H(TYKNU_OVARY)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			48	15					0	0	1	0	0
TMEM175	84286	broad.mit.edu	37	4	947001	947001	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:947001C>A	ENST00000264771.4	+	8	671	c.486C>A	c.(484-486)ttC>ttA	p.F162L	TMEM175_ENST00000508204.1_Missense_Mutation_p.F80L|TMEM175_ENST00000515740.1_Missense_Mutation_p.F46L|TMEM175_ENST00000504180.1_3'UTR	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	162						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GGTACGCATTCCACTTCCCGC	0.657000													4	25					0.00909568	0.00922183	1	1	0
HIPK4	147746	broad.mit.edu	37	19	40886303	40886303	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:40886303G>A	ENST00000291823.2	-	3	1879	c.1595C>T	c.(1594-1596)tCt>tTt	p.S532F		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	532						cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TGGCTCAGCAGAGGCCCCGAG	0.607000													7	68					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36793594	36793594	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:36793594C>T	ENST00000361475.2	-	1	180	c.7G>A	c.(7-9)Gag>Aag	p.E3K	TGM2_ENST00000536701.1_Missense_Mutation_p.E3K|TGM2_ENST00000536724.1_Missense_Mutation_p.E3K	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	3					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	TACTCACCCTCGGCCATGGTC	0.687000													18	24					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603734	111603734	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:111603734C>G	ENST00000431670.2	+	2	1221	c.810C>G	c.(808-810)ctC>ctG	p.L270L	PHLDB2_ENST00000393923.3_Silent_p.L297L|PHLDB2_ENST00000478922.1_Silent_p.L270L|PHLDB2_ENST00000393925.3_Silent_p.L270L|PHLDB2_ENST00000477695.1_Silent_p.L270L|PHLDB2_ENST00000412622.1_Silent_p.L270L|PHLDB2_ENST00000481953.1_Silent_p.L270L	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	270						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						TGACACCTCTCAGCTTGCCTC	0.478000													13	53					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47500910	47500910	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:47500910G>A	ENST00000285039.7	-	10	1431	c.1132C>T	c.(1132-1134)Cat>Tat	p.H378Y		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	378	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		AGCTTGCGATGACACAGCCAG	0.577000													49	37					0	0	1	0	0
WIPF3	644150	broad.mit.edu	37	7	29915522	29915522	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:29915522G>A	ENST00000409290.1	+	2	167	c.167G>A	c.(166-168)gGa>gAa	p.G56E	WIPF3_ENST00000409123.1_Missense_Mutation_p.G56E|WIPF3_ENST00000242140.5_Missense_Mutation_p.G56E	NM_001080529.2	NP_001073998.2	B8ZZV2	B8ZZV2_HUMAN	WAS/WASL interacting protein family, member 3	56										breast(2)|large_intestine(3)|lung(6)|ovary(1)	12						ATCCAGCAAGGAACTCGCCTG	0.582000													9	58					0	0	1	0	0
TMCO3	55002	broad.mit.edu	37	13	114150069	114150069	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:114150069C>T	ENST00000434316.2	+	2	532	c.173C>T	c.(172-174)tCa>tTa	p.S58L	TMCO3_ENST00000474393.1_3'UTR|TMCO3_ENST00000375391.1_Missense_Mutation_p.S58L	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	58						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			AGGAAGCTCTCAGGGCTTCTC	0.582000													12	18					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79269994	79269994	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:79269994G>C	ENST00000554719.1	+	6	1448	c.957G>C	c.(955-957)atG>atC	p.M319I	NRXN3_ENST00000335750.5_Missense_Mutation_p.M319I	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		ATGGTAGCATGTACATGAAGA	0.498000													49	75					0	0	1	0	0
CREBZF	58487	broad.mit.edu	37	11	85374910	85374910	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:85374910G>A	ENST00000527447.1	-	1	1236	c.1010C>T	c.(1009-1011)tCg>tTg	p.S337L	CREBZF_ENST00000534224.1_Intron|CREBZF_ENST00000531515.1_Intron|CREBZF_ENST00000398294.2_Missense_Mutation_p.S255L	NM_001039618.2	NP_001034707.1	Q9NS37	ZHANG_HUMAN	CREB/ATF bZIP transcription factor	337					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				GAACTCCACCGACACCTTATC	0.562000											OREG0021274	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	122					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43944794	43944794	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:43944794G>A	ENST00000389420.3	-	2	370	c.371C>T	c.(370-372)tCg>tTg	p.S124L	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.S124L	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	124						proteinaceous extracellular matrix	zinc ion binding	p.S124*(2)		breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GCGCAGGTCCGAGGGCCCTGC	0.667000													10	5					0	0	1	0	0
ZBTB38	253461	broad.mit.edu	37	3	141163197	141163197	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:141163197G>T	ENST00000514251.1	+	4	2246	c.1967G>T	c.(1966-1968)gGa>gTa	p.G656V	ZBTB38_ENST00000441582.2_Missense_Mutation_p.G656V|ZBTB38_ENST00000321464.5_Missense_Mutation_p.G657V			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	656					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						ACCAAATGGGGAGAGGAGGCA	0.468000													20	119					1.00905e-13	1.09114e-13	1	1	0
C10orf12	26148	broad.mit.edu	37	10	98742417	98742417	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:98742417G>C	ENST00000286067.2	+	1	1377	c.1270G>C	c.(1270-1272)Gag>Cag	p.E424Q		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	424										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TGCTGAGGTTGAGTCTGGAGA	0.512000													10	150					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44921538	44921538	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:44921538C>T	ENST00000261866.7	-	9	1800	c.1784G>A	c.(1783-1785)aGa>aAa	p.R595K	SPG11_ENST00000559193.1_Missense_Mutation_p.R595K|SPG11_ENST00000427534.2_Missense_Mutation_p.R595K|SPG11_ENST00000535302.2_Missense_Mutation_p.R595K|SPG11_ENST00000558319.1_Missense_Mutation_p.R595K	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	595					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		ATAACTTTCTCTAATTGCCGA	0.358000													4	77					0	0	1	0	0
RHOT1	55288	broad.mit.edu	37	17	30525994	30525994	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:30525994G>A	ENST00000358365.3	+	12	1125	c.898G>A	c.(898-900)Gaa>Aaa	p.E300K	RHOT1_ENST00000580976.1_3'UTR|RHOT1_ENST00000581094.1_Missense_Mutation_p.E300K|RHOT1_ENST00000354266.3_Missense_Mutation_p.E279K|RHOT1_ENST00000545287.2_Missense_Mutation_p.E300K|RHOT1_ENST00000394692.2_Missense_Mutation_p.E300K|RHOT1_ENST00000583994.1_Missense_Mutation_p.E173K|RHOT1_ENST00000333942.6_Missense_Mutation_p.E300K	NM_001033568.1	NP_001028740.1	Q8IXI2	MIRO1_HUMAN	ras homolog family member T1	300					apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			NS(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				TTGCACTACTGAATTAAATCA	0.259000													26	82					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45354112	45354112	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:45354112G>A	ENST00000359271.2	+	2	687	c.437G>A	c.(436-438)gGc>gAc	p.G146D		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	146						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				ATCACCGTGGGCATCCTGCTC	0.622000													20	99					0	0	1	0	0
PLEKHA3	65977	broad.mit.edu	37	2	179368594	179368594	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:179368594C>T	ENST00000234453.5	+	8	1285	c.883C>T	c.(883-885)Ctt>Ttt	p.L295F		NM_019091.3	NP_061964.3	Q9HB20	PKHA3_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3							cytoplasm|membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	11			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.0266)|all cancers(119;0.0865)			AGAAGATACTCTTCCATCCTT	0.368000													9	63					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58256149	58256149	+	Silent	SNP	G	G	A	rs114347273	by1000genomes	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:58256149G>A	ENST00000249750.4	-	9	1787	c.1020C>T	c.(1018-1020)agC>agT	p.S340S	ALDH1A2_ENST00000347587.3_Silent_p.S302S|ALDH1A2_ENST00000558231.1_Silent_p.S311S|ALDH1A2_ENST00000559517.1_Silent_p.S244S|ALDH1A2_ENST00000537372.1_Silent_p.S319S	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	340					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CCCGCTCCACGCTTCTTCTCA	0.542000													26	84					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47583998	47583998	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:47583998G>A	ENST00000273859.3	+	21	3939	c.3670G>A	c.(3670-3672)Gac>Aac	p.D1224N	ATP10D_ENST00000512393.1_3'UTR	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1224					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						CTCAGATACTGACATCTTTGC	0.463000													37	99					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49440294	49440294	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:49440294G>A	ENST00000374201.3	-	10	1334	c.1032C>T	c.(1030-1032)ctC>ctT	p.L344L	FRMPD2_ENST00000407470.4_Silent_p.L313L|FRMPD2_ENST00000305531.3_Silent_p.L320L	NM_001018071.3|NM_001042512.2	NP_001018081|NP_001035977.2	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	344	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GGACCACACAGAGGTCCCTGA	0.448000													20	46					0	0	1	0	0
LUC7L	55692	broad.mit.edu	37	16	270656	270656	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:270656C>G	ENST00000337351.4	-	3	370	c.247G>C	c.(247-249)Gaa>Caa	p.E83Q	LUC7L_ENST00000293872.8_Missense_Mutation_p.E83Q|LUC7L_ENST00000397783.1_Missense_Mutation_p.E83Q|LUC7L_ENST00000397780.1_Missense_Mutation_p.E30Q|LUC7L_ENST00000494366.1_5'UTR	NM_018032.3	NP_060502.1	Q9NQ29	LUC7L_HUMAN	LUC7-like (S. cerevisiae)	83							metal ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	11		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				ACATCTAATTCAAAAAACAGG	0.353000													60	98					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106066677	106066677	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:106066677C>G	ENST00000357242.5	+	5	982	c.808C>G	c.(808-810)Cct>Gct	p.P270A	TBC1D8B_ENST00000310452.2_Missense_Mutation_p.P270A|TBC1D8B_ENST00000276175.3_Missense_Mutation_p.P270A|TBC1D8B_ENST00000481617.2_Missense_Mutation_p.P270A	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	270						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CCTTTATAATCCTCTACAGAT	0.313000													55	21					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139918544	139918544	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:139918544C>G	ENST00000297183.6	+	33	7569	c.7445C>G	c.(7444-7446)tCt>tGt	p.S2482C	ANKHD1_ENST00000360839.2_Missense_Mutation_p.S2482C|ANKHD1_ENST00000544120.1_Missense_Mutation_p.S806C|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.S2482C	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAATACCCTCTCATCCTCAG	0.363000													14	29					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36696992	36696992	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:36696992C>T	ENST00000216181.5	-	22	2973	c.2743G>A	c.(2743-2745)Gag>Aag	p.E915K		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	915					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						TGGCAGATCTCTTCTAATTCC	0.607000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				54	76					0	0	1	0	0
CRTC3	64784	broad.mit.edu	37	15	91182020	91182020	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:91182020G>A	ENST00000420329.2	+	13	1668	c.1521G>A	c.(1519-1521)atG>atA	p.M507I	CRTC3_ENST00000268184.6_Missense_Mutation_p.M507I|RP11-387D10.2_ENST00000559531.1_RNA	NM_001042574.2|NM_022769.4	NP_001036039.1|NP_073606.3	Q6UUV7	CRTC3_HUMAN	CREB regulated transcription coactivator 3	507					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	breast(1)|endometrium(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			AGCAGTCCATGAGGCCAGGCC	0.488000			T	MAML2	salivary gland mucoepidermoid								4	64					0	0	1	0	0
OR13F1	138805	broad.mit.edu	37	9	107266864	107266864	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:107266864G>A	ENST00000334726.2	+	1	410	c.321G>A	c.(319-321)atG>atA	p.M107I		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CCCTTGCCATGGGCTCCACTG	0.522000													25	41					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803228	185803228	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:185803228G>A	ENST00000302277.6	+	4	3699	c.3105G>A	c.(3103-3105)ttG>ttA	p.L1035L		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1035						intracellular	zinc ion binding	p.L1035F(1)		NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAGCATTATTGATCCCACTAG	0.413000													40	65					0	0	1	0	0
MRPL43	84545	broad.mit.edu	37	10	102741296	102741296	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:102741296G>A	ENST00000299179.5	-	5	583	c.533C>T	c.(532-534)tCa>tTa	p.S178L	SEMA4G_ENST00000517724.1_Intron|MRPL43_ENST00000318325.2_Intron|MRPL43_ENST00000342071.1_Silent_p.I220I|MRPL43_ENST00000370241.3_Intron|MRPL43_ENST00000370242.4_Intron|SEMA4G_ENST00000370250.4_Intron|RP11-108L7.4_ENST00000447344.1_RNA|SEMA4G_ENST00000210633.3_Intron	NM_176793.1	NP_789763.1	Q8N983	RM43_HUMAN	mitochondrial ribosomal protein L43	178					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome			endometrium(1)|skin(2)|upper_aerodigestive_tract(1)	4		Colorectal(252;0.234)		Epithelial(162;6.21e-09)|all cancers(201;3.14e-07)		TGACTGAACTGATATCTGAAG	0.398000													18	70					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9459591	9459591	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:9459591G>A	ENST00000378501.2	+	36	3535	c.3520G>A	c.(3520-3522)Gaa>Aaa	p.E1174K	PLCB4_ENST00000278655.4_Silent_p.V1161V|PLCB4_ENST00000334005.3_Missense_Mutation_p.E1174K|PLCB4_ENST00000414679.2_Silent_p.V1173V|PLCB4_ENST00000378493.1_Silent_p.V1161V|PLCB4_ENST00000378473.3_Silent_p.V1173V|PLCB4_ENST00000492632.1_3'UTR	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	507					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AGCAGATGGTGAAATTGGAAG	0.458000													8	36					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169212970	169212970	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:169212970G>C	ENST00000393743.3	-	8	1261	c.970C>G	c.(970-972)Ctt>Gtt	p.L324V		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	324							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CTTTGAGAAAGAGGCAGATGG	0.378000													5	106					0	0	1	0	0
PTCD3	55037	broad.mit.edu	37	2	86364195	86364195	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:86364195C>T	ENST00000254630.7	+	23	1977	c.1911C>T	c.(1909-1911)ttC>ttT	p.F637F		NM_017952.5	NP_060422.4	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3	637						mitochondrion	protein binding			NS(1)|breast(2)|endometrium(3)|kidney(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	22						CAAGTGCCTTCAGCTTACCTA	0.438000													27	169					0	0	1	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4455916	4455916	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:4455916C>T	ENST00000254718.4	-	6	873	c.567G>A	c.(565-567)tcG>tcA	p.S189S	MYBBP1A_ENST00000381556.2_Silent_p.S189S			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	189	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						ATGTGGCCTTCGAGACCTAAG	0.572000													8	33					0	0	1	0	0
AGPS	8540	broad.mit.edu	37	2	178301571	178301571	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:178301571C>T	ENST00000264167.4	+	4	667	c.521C>T	c.(520-522)tCa>tTa	p.S174L	AGPS_ENST00000409888.1_Intron	NM_003659.3	NP_003650.1	O00116	ADAS_HUMAN	alkylglycerone phosphate synthase	174					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			ACTAATATTTCATATTCACAA	0.284000													6	110					0	0	1	0	0
DGCR2	9993	broad.mit.edu	37	22	19044633	19044633	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:19044633G>A	ENST00000263196.7	-	6	915	c.668C>T	c.(667-669)tCg>tTg	p.S223L	DGCR2_ENST00000473832.1_5'UTR|DGCR2_ENST00000537045.1_Missense_Mutation_p.S182L|DGCR2_ENST00000545799.1_3'UTR	NM_001184781.1|NM_005137.2	NP_001171710.1|NP_005128.1	P98153	IDD_HUMAN	DiGeorge syndrome critical region gene 2	223	C-type lectin.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)	18	Colorectal(54;0.0993)					AGACATGGCCGAGGCAAAGAT	0.592000													4	13					0	0	1	0	0
S1PR1	1901	broad.mit.edu	37	1	101704981	101704981	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:101704981G>A	ENST00000305352.6	+	2	816	c.441G>A	c.(439-441)ctG>ctA	p.L147L	S1PR1_ENST00000475821.1_3'UTR	NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	147					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						TCACAATGCTGAAAATGAAAC	0.557000											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	47	52					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22178416	22178416	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:22178416G>A	ENST00000374695.3	-	54	6953	c.6874C>T	c.(6874-6876)Cgt>Tgt	p.R2292C	HSPG2_ENST00000430507.1_3'UTR	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	2292	Ig-like C2-type 8.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGGGAGCCACGAACCTGGGCA	0.672000													7	14					0	0	1	0	0
EN1	2019	broad.mit.edu	37	2	119600601	119600601	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:119600601G>C	ENST00000295206.6	-	2	1602	c.1092C>G	c.(1090-1092)atC>atG	p.I364M		NM_001426.3	NP_001417.3	Q05925	HME1_HUMAN	engrailed homeobox 1	364					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	9						GGCCGTTCTTGATGCCTGTGG	0.612000													8	43					0	0	1	0	0
COG3	83548	broad.mit.edu	37	13	46103990	46103990	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:46103990G>A	ENST00000349995.5	+	21	2407	c.2295G>A	c.(2293-2295)ttG>ttA	p.L765L		NM_031431.3	NP_113619	Q96JB2	COG3_HUMAN	component of oligomeric golgi complex 3	765					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|skin(2)|stomach(1)	24		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		CTGTGACATTGAGAAGTATGT	0.388000													38	25					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16590352	16590352	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:16590352C>G	ENST00000502640.1	-	4	660	c.512G>C	c.(511-513)aGa>aCa	p.R171T	LDB2_ENST00000503829.1_5'UTR|LDB2_ENST00000304523.5_Missense_Mutation_p.R171T|LDB2_ENST00000503178.2_Missense_Mutation_p.R47T|LDB2_ENST00000515064.1_Missense_Mutation_p.R171T|LDB2_ENST00000441778.2_Missense_Mutation_p.R171T			O43679	LDB2_HUMAN	LIM domain binding 2	171							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						TAGGATGCTTCTCGGGACTAA	0.393000													6	62					0	0	1	0	0
APOL1	8542	broad.mit.edu	37	22	36661254	36661254	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:36661254G>A	ENST00000319136.4	+	7	687	c.420G>A	c.(418-420)atG>atA	p.M140I	APOL1_ENST00000397278.3_Missense_Mutation_p.M124I|APOL1_ENST00000347595.7_Missense_Mutation_p.M3I|APOL1_ENST00000397279.4_Missense_Mutation_p.M124I|APOL1_ENST00000422706.1_Missense_Mutation_p.M124I|APOL1_ENST00000426053.1_Missense_Mutation_p.M106I|APOL1_ENST00000440669.2_3'UTR	NM_145343.2	NP_663318.1	O14791	APOL1_HUMAN	apolipoprotein L, 1	124					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	14						AAATGATCATGAAAGACAAAA	0.428000													21	68					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222414	140222414	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:140222414C>T	ENST00000531613.1	+	1	1508	c.1508C>T	c.(1507-1509)tCg>tTg	p.S503L	PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.S503L|PCDHA6_ENST00000529310.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAGCGCTCGCTGTCGAGC	0.667000													39	30					0	0	1	0	0
CTNNAL1	8727	broad.mit.edu	37	9	111746665	111746665	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:111746665G>A	ENST00000374595.4	-	5	770	c.691C>T	c.(691-693)Ctt>Ttt	p.L231F	CTNNAL1_ENST00000325580.6_Missense_Mutation_p.L231F|CTNNAL1_ENST00000325551.4_Missense_Mutation_p.L231F			Q9UBT7	CTNL1_HUMAN	catenin (cadherin-associated protein), alpha-like 1	231					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(4)|urinary_tract(2)	25				STAD - Stomach adenocarcinoma(157;0.0768)		CACTTTTCAAGAACTGCCCTA	0.348000													32	106					0	0	1	0	0
BMPR1A	657	broad.mit.edu	37	10	88651946	88651946	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:88651946C>T	ENST00000372037.3	+	5	830	c.293C>T	c.(292-294)tCa>tTa	p.S98L		NM_004329.2	NP_004320.2	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA						BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|skin(1)|stomach(1)	24						ACATTAGCTTCAGGGTGTATG	0.363000			"""Mis, N, F"""			gastrointestinal polyps			Juvenile Polyposis;Hereditary Mixed Polyposis syndrome type 2				9	28					0	0	1	0	0
SCAPER	49855	broad.mit.edu	37	15	76673922	76673922	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:76673922G>A	ENST00000538941.2	-	28	3703	c.2764C>T	c.(2764-2766)Ccc>Tcc	p.P922S	SCAPER_ENST00000324767.7_Missense_Mutation_p.P1168S|SCAPER_ENST00000563290.1_Missense_Mutation_p.P1168S	NM_001145923.1	NP_001139395.1	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1167						endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						AGCCCTGTGGGATCCTGGCGA	0.453000													4	13					0	0	1	0	0
ZNF133	7692	broad.mit.edu	37	20	18297183	18297183	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:18297183C>G	ENST00000377671.3	+	7	2244	c.1685C>G	c.(1684-1686)tCa>tGa	p.S562*	ZNF133_ENST00000462170.1_3'UTR|ZNF133_ENST00000538547.1_Nonsense_Mutation_p.S468*|ZNF133_ENST00000401790.1_Nonsense_Mutation_p.S563*|ZNF133_ENST00000316358.4_Nonsense_Mutation_p.S563*|ZNF133_ENST00000396026.3_Nonsense_Mutation_p.S566*|ZNF133_ENST00000535822.1_Nonsense_Mutation_p.S468*|ZNF133_ENST00000402618.2_Nonsense_Mutation_p.S500*	NM_001083330.2|NM_003434.4	NP_001076799.1|NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	563						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26						GGCAATAAGTCAGCTCTAATT	0.542000													23	51					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95556077	95556077	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:95556077G>A	ENST00000297591.5	-	2	232	c.157C>T	c.(157-159)Ctg>Ttg	p.L53L	KIAA1429_ENST00000421249.2_Silent_p.L53L|KIAA1429_ENST00000437199.1_Silent_p.L53L	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	53					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTGTCTGGCAGACTGCTATGG	0.358000													38	166					0	0	1	0	0
C1orf198	84886	broad.mit.edu	37	1	231004195	231004195	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:231004195G>C	ENST00000366663.5	-	1	204	c.64C>G	c.(64-66)Ctg>Gtg	p.L22V	C1orf198_ENST00000470540.1_Intron|C1orf198_ENST00000427697.2_Intron	NM_032800.2	NP_116189.1	Q9H425	CA198_HUMAN	chromosome 1 open reading frame 198	22										breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	17	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				CGGTCGTCCAGAGGCCGGTTC	0.697000													5	10					0	0	1	0	0
KCTD6	200845	broad.mit.edu	37	3	58486802	58486802	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:58486802C>T	ENST00000355076.6	+	2	1140	c.157C>T	c.(157-159)Caa>Taa	p.Q53*	KCTD6_ENST00000479470.1_3'UTR|KCTD6_ENST00000404589.3_Nonsense_Mutation_p.Q53*|KCTD6_ENST00000490264.1_Nonsense_Mutation_p.Q53*	NM_153331.3	NP_699162.3	Q8NC69	KCTD6_HUMAN	potassium channel tetramerization domain containing 6	53	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(1)|large_intestine(2)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(55;0.000177)|Kidney(10;0.00229)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.148)		TCGAGACCCTCAAGGCAATTA	0.453000													40	77					0	0	1	0	0
ZC3H14	79882	broad.mit.edu	37	14	89034385	89034385	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:89034385G>A	ENST00000251038.5	+	3	307	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	ZC3H14_ENST00000336693.4_5'UTR|ZC3H14_ENST00000555755.1_Missense_Mutation_p.E28K|ZC3H14_ENST00000359301.3_5'UTR|ZC3H14_ENST00000393514.5_Missense_Mutation_p.E28K|ZC3H14_ENST00000302216.8_Missense_Mutation_p.E28K|ZC3H14_ENST00000557607.1_Intron|ZC3H14_ENST00000556945.1_Missense_Mutation_p.E28K	NM_001160103.1|NM_001160104.1|NM_024824.4	NP_001153575.1|NP_001153576.1|NP_079100.2	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14	28						cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(2)	21						TTAAATAGATGAAGAACTTCC	0.363000													8	36					0	0	1	0	0
ZNF10	7556	broad.mit.edu	37	12	133732614	133732614	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:133732614G>C	ENST00000248211.6	+	5	1004	c.782G>C	c.(781-783)aGa>aCa	p.R261T	ZNF10_ENST00000426665.2_Missense_Mutation_p.R261T|ZNF10_ENST00000402932.2_Intron|ZNF268_ENST00000416488.1_Intron|CTD-2140B24.4_ENST00000540096.2_Intron	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	261				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GGCATACATAGAGAGAAACCC	0.393000													12	51					0	0	1	0	0
ACTR1B	10120	broad.mit.edu	37	2	98274919	98274919	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:98274919C>T	ENST00000289228.5	-	6	844	c.628G>A	c.(628-630)Gag>Aag	p.E210K		NM_005735.3	NP_005726.1	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B, centractin beta (yeast)	210						centrosome|dynactin complex	ATP binding|protein binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	15						ACCTCAAACTCAGCCGAGGTA	0.617000													7	30					0	0	1	0	0
LPP	4026	broad.mit.edu	37	3	188327169	188327169	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:188327169C>T	ENST00000312675.4	+	6	896	c.650C>T	c.(649-651)tCa>tTa	p.S217L	LPP_ENST00000543006.1_Missense_Mutation_p.S217L|LPP_ENST00000448637.1_Missense_Mutation_p.S217L|LPP_ENST00000471917.1_3'UTR	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	217	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		TCCACTTCTTCAAGGCCTACC	0.592000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								12	91					0	0	1	0	0
SLC25A16	8034	broad.mit.edu	37	10	70276532	70276532	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:70276532G>A	ENST00000609923.1	-	2	297	c.199C>T	c.(199-201)Cac>Tac	p.H67Y	SLC25A16_ENST00000539557.1_5'UTR|SLC25A16_ENST00000265870.3_5'UTR	NM_152707.3	NP_689920.1	P16260	GDC_HUMAN	solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16						coenzyme biosynthetic process|pantothenate metabolic process	integral to membrane|mitochondrial inner membrane	binding|solute:solute antiporter activity			endometrium(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	7						TGGTGATTGTGAGCTTGTAAT	0.333000													15	33					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158735144	158735144	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:158735144G>A	ENST00000367097.3	+	1	1453	c.96G>A	c.(94-96)gaG>gaA	p.E32E	TULP4_ENST00000367094.2_Silent_p.E32E	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	32					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GTGAGAAGGAGAAGCCTGTGT	0.572000													14	27					0	0	1	0	0
CPD	1362	broad.mit.edu	37	17	28747979	28747979	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:28747979C>T	ENST00000225719.4	+	3	1191	c.1115C>T	c.(1114-1116)tCt>tTt	p.S372F	CPD_ENST00000543464.2_Missense_Mutation_p.S125F	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	372	Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						AATCGTGAGTCTTTGATCACA	0.398000													5	61					0	0	1	0	0
G2E3	55632	broad.mit.edu	37	14	31074728	31074728	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:31074728G>C	ENST00000206595.6	+	11	1182	c.1028G>C	c.(1027-1029)aGa>aCa	p.R343T	G2E3_ENST00000544007.1_Intron|G2E3_ENST00000438909.2_Missense_Mutation_p.R297T|G2E3_ENST00000553504.1_Missense_Mutation_p.R373T	NM_017769.3	NP_060239.2	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin protein ligase	343					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						AGCAAATTTAGAAGAAATGTA	0.269000													8	28					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113724603	113724603	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:113724603G>A	ENST00000295878.3	-	10	1766	c.1620C>T	c.(1618-1620)acC>acT	p.T540T	KIAA1407_ENST00000545063.1_Silent_p.T371T	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	540										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						CTTTCTGGCTGGTAGTTCTGA	0.507000													9	220					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170965666	170965666	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:170965666G>C	ENST00000367759.4	+	14	1510	c.1356G>C	c.(1354-1356)ctG>ctC	p.L452L	MROH9_ENST00000367758.3_Silent_p.L452L	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		AGGATGCCCTGAGAGTTCTGC	0.418000													20	109					0	0	1	0	0
CELF6	60677	broad.mit.edu	37	15	72581516	72581516	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:72581516G>A	ENST00000287202.5	-	8	1247	c.993C>T	c.(991-993)tcC>tcT	p.S331S	CELF6_ENST00000567083.1_Silent_p.S331S|RP11-106M3.3_ENST00000570175.1_RNA|CELF6_ENST00000569547.1_Silent_p.S331S|CELF6_ENST00000539635.1_Silent_p.S192S|CELF6_ENST00000543764.2_Silent_p.S215S|RP11-106M3.2_ENST00000379915.4_RNA|CELF6_ENST00000395258.2_Silent_p.S218S	NM_052840.4	NP_443072.3	Q96J87	CELF6_HUMAN	CUGBP, Elav-like family member 6	331					mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(2)	13						AGAGCGTGTCGGAGCCCGGCT	0.692000													3	5					0	0	1	0	0
TSNARE1	203062	broad.mit.edu	37	8	143396398	143396398	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:143396398G>A	ENST00000519651.1	-	6	483	c.380C>T	c.(379-381)tCa>tTa	p.S127L	TSNARE1_ENST00000518928.1_5'UTR|TSNARE1_ENST00000520166.1_Missense_Mutation_p.S346L|TSNARE1_ENST00000307180.3_Missense_Mutation_p.S347L|TSNARE1_ENST00000524325.1_Missense_Mutation_p.S346L			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	347					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					AATGGCATCTGAGAGCTGGGT	0.647000													11	72					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95108138	95108138	+	RNA	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:95108138G>A	ENST00000469935.1	+	0	743					NR_015340.1																						ACACATTGACGAATATACAGA	0.622000													62	91					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66360334	66360334	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:66360334C>T	ENST00000333861.3	-	1	220	c.153G>A	c.(151-153)gcG>gcA	p.A51A	CCS_ENST00000533244.1_5'UTR	NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	51										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CCGTCAGCTTCGCCAGAGGGA	0.677000											OREG0021111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	49					0	0	1	0	0
SMARCB1	6598	broad.mit.edu	37	22	24129380	24129380	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:24129380G>C	ENST00000344921.6	+	1	231	c.24G>C	c.(22-24)aaG>aaC	p.K8N	SMARCB1_ENST00000407082.3_Missense_Mutation_p.K8N|SMARCB1_ENST00000407422.3_Missense_Mutation_p.K8N|SMARCB1_ENST00000263121.7_Missense_Mutation_p.K8N			Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	8					cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(2)		bone(4)|central_nervous_system(198)|endometrium(4)|haematopoietic_and_lymphoid_tissue(25)|kidney(3)|large_intestine(5)|liver(2)|lung(5)|meninges(5)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|soft_tissue(194)	458		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				CGCTGAGCAAGACCTTCGGGC	0.711000			"""D, N, F, S"""		malignant rhabdoid	malignant rhabdoid							11	38					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	72994488	72994488	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:72994488G>T	ENST00000308744.6	+	2	584	c.486G>T	c.(484-486)atG>atT	p.M162I	NPFFR2_ENST00000358749.3_Missense_Mutation_p.M60I|NPFFR2_ENST00000395999.1_Missense_Mutation_p.M63I|NPFFR2_ENST00000344413.5_Intron	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	162					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TTTTGTGCATGATGGGAAATA	0.358000													22	136					3.5997e-14	3.89834e-14	1	1	0
DNASE1L3	1776	broad.mit.edu	37	3	58196496	58196496	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:58196496C>T	ENST00000483681.1	-	3	719	c.138G>A	c.(136-138)gtG>gtA	p.V46V	DNASE1L3_ENST00000394549.2_Silent_p.V46V|DNASE1L3_ENST00000486455.1_Silent_p.V46V|DNASE1L3_ENST00000318316.3_Silent_p.V46V			Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3	46					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(4)|lung(6)	12				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		GGCTCACCTTCACAATGACAT	0.537000													12	299					0	0	1	0	0
SLC25A27	9481	broad.mit.edu	37	6	46644175	46644175	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:46644175G>A	ENST00000371347.5	+	9	1208	c.956G>A	c.(955-957)gGa>gAa	p.G319E	RP11-446F17.3_ENST00000571590.1_RNA|SLC25A27_ENST00000411689.2_Intron|RP11-446F17.3_ENST00000434329.2_RNA|RP11-446F17.3_ENST00000422284.2_RNA|SLC25A27_ENST00000452689.2_Missense_Mutation_p.G233E	NM_001204051.1|NM_004277.4	NP_001190980.1|NP_004268.3	O95847	UCP4_HUMAN	solute carrier family 25, member 27	319					generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane				central_nervous_system(1)|kidney(1)|lung(4)|prostate(1)|urinary_tract(1)	8			Lung(136;0.192)			GAGATGAGTGGAGTCAGTCCA	0.368000													20	87					0	0	1	0	0
RBBP5	5929	broad.mit.edu	37	1	205070807	205070807	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:205070807G>C	ENST00000264515.6	-	6	694	c.553C>G	c.(553-555)Ctt>Gtt	p.L185V	RBBP5_ENST00000367164.1_Missense_Mutation_p.L185V	NM_001193273.1|NM_005057.3	NP_001180202.1|NP_005048.2	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	185					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			cervix(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	27	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			GAAGCAACAAGATCCTGAGAA	0.393000													59	122					0	0	1	0	0
FOXD4L1	200350	broad.mit.edu	37	2	114257298	114257298	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:114257298C>T	ENST00000306507.5	+	1	638	c.465C>T	c.(463-465)atC>atT	p.I155I		NM_012184.4	NP_036316.1	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	155					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(2)	26						AGAACAGCATCCGCCACAACC	0.662000													11	276					0	0	1	0	0
SERPINA7	6906	broad.mit.edu	37	X	105281031	105281031	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:105281031G>A	ENST00000327674.4	-	1	354	c.19C>T	c.(19-21)Ctg>Ttg	p.L7L	SERPINA7_ENST00000372563.1_Silent_p.L7L			P05543	THBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	7					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|skin(3)	24					Levothyroxine(DB00451)|Liothyronine(DB00279)	AAGAGAACCAGATACAGGAAT	0.458000													7	59					0	0	1	0	0
QRICH1	54870	broad.mit.edu	37	3	49081854	49081854	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:49081854C>T	ENST00000395443.2	-	6	2227	c.1755G>A	c.(1753-1755)ctG>ctA	p.L585L	QRICH1_ENST00000357496.2_Silent_p.L585L|QRICH1_ENST00000424300.1_Silent_p.L585L|QRICH1_ENST00000479449.1_5'UTR	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	585										breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GAACATCCTTCAGAACTTCAT	0.403000													7	188					0	0	1	0	0
CAST	831	broad.mit.edu	37	5	96086315	96086315	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:96086315C>T	ENST00000395813.1	+	20	1639	c.1453C>T	c.(1453-1455)Cct>Tct	p.P485S	CAST_ENST00000515663.1_Missense_Mutation_p.P125S|CAST_ENST00000348386.3_3'UTR|CAST_ENST00000325674.7_Missense_Mutation_p.P450S|CAST_ENST00000395812.2_Missense_Mutation_p.P444S|CAST_ENST00000511049.1_Missense_Mutation_p.P388S|CAST_ENST00000309190.5_Missense_Mutation_p.P380S|CAST_ENST00000510756.1_Missense_Mutation_p.P463S|CAST_ENST00000508579.1_Missense_Mutation_p.P117S|CAST_ENST00000341926.3_Missense_Mutation_p.P402S|CAST_ENST00000511782.1_Missense_Mutation_p.P388S|CAST_ENST00000504465.1_Missense_Mutation_p.P330S|CAST_ENST00000359176.4_Missense_Mutation_p.P466S|CAST_ENST00000509903.1_Missense_Mutation_p.P367S|CAST_ENST00000508608.1_Missense_Mutation_p.P448S|CAST_ENST00000338252.3_Missense_Mutation_p.P389S|CAST_ENST00000508830.1_Missense_Mutation_p.P485S	NM_001284213.1	NP_001271142.1	P20810	ICAL_HUMAN	calpastatin	402							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	22		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		TGCTCCAGCTCCTGTGTCGGA	0.488000													10	29					0	0	1	0	0
MAGEH1	28986	broad.mit.edu	37	X	55479335	55479335	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:55479335C>T	ENST00000342972.1	+	1	798	c.528C>T	c.(526-528)gtC>gtT	p.V176V		NM_014061.3	NP_054780.2	Q9H213	MAGH1_HUMAN	melanoma antigen family H, 1	176	MAGE.				apoptosis					central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|skin(2)	15						AACTGAAAGTCATGCATTTTG	0.512000													43	15					0	0	1	0	0
CDC27	996	broad.mit.edu	37	17	45229303	45229303	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:45229303C>G	ENST00000531206.1	-	9	961		c.e9-1		CDC27_ENST00000527547.1_Intron|CDC27_ENST00000066544.3_Intron|CDC27_ENST00000446365.2_Intron			P30260	CDC27_HUMAN	cell division cycle 27						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						CACGAAAAGTCTAAGGTTTGT	0.413000													30	44					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6181225	6181225	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:6181225G>A	ENST00000262450.3	-	33	4951	c.4852C>T	c.(4852-4854)Cga>Tga	p.R1618*	CHD5_ENST00000378021.1_Nonsense_Mutation_p.R475*	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1618					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CGCTCCTCTCGGGCTCTCTCC	0.647000													7	16					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169939910	169939910	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:169939910G>A	ENST00000327239.4	+	6	1889	c.385G>A	c.(385-387)Gac>Aac	p.D129N	DHRS9_ENST00000412271.1_Missense_Mutation_p.D129N|DHRS9_ENST00000602501.1_Missense_Mutation_p.D129N|DHRS9_ENST00000436483.2_Missense_Mutation_p.D129N|DHRS9_ENST00000432060.2_Missense_Mutation_p.D189N|DHRS9_ENST00000357546.2_Missense_Mutation_p.D129N|DHRS9_ENST00000421653.1_5'UTR|DHRS9_ENST00000428522.1_Missense_Mutation_p.D129N	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	129					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						GACACTAGAGGACTACAGAGA	0.468000													16	119					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17681136	17681136	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:17681136G>A	ENST00000375448.4	+	11	1290	c.1264G>A	c.(1264-1266)Gaa>Aaa	p.E422K	PADI4_ENST00000487048.1_3'UTR	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	422					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CAGGGGCAAGGAATACCCGCT	0.572000													20	18					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186082010	186082010	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:186082010G>A	ENST00000271588.4	+	72	11285	c.11056G>A	c.(11056-11058)Gat>Aat	p.D3686N	HMCN1_ENST00000367492.2_Missense_Mutation_p.D3686N	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3686	Ig-like C2-type 35.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TGACCTAGGTGATACAGCCAA	0.403000													21	74					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603414	111603414	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:111603414C>G	ENST00000431670.2	+	2	901	c.490C>G	c.(490-492)Ctt>Gtt	p.L164V	PHLDB2_ENST00000393923.3_Missense_Mutation_p.L191V|PHLDB2_ENST00000478922.1_Missense_Mutation_p.L164V|PHLDB2_ENST00000393925.3_Missense_Mutation_p.L164V|PHLDB2_ENST00000477695.1_Missense_Mutation_p.L164V|PHLDB2_ENST00000412622.1_Missense_Mutation_p.L164V|PHLDB2_ENST00000481953.1_Missense_Mutation_p.L164V	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	164						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						TGTCTACTCTCTTGGAGGGCT	0.542000													24	95					0	0	1	0	0
IGLV2-33	28811	broad.mit.edu	37	22	22930878	22930878	+	RNA	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:22930878C>T	ENST00000390302.2	+	0	131																											TGCCCTGACTCAGCCTCCTTT	0.567000													44	169					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53639396	53639396	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:53639396C>T	ENST00000262135.4	-	24	3685	c.3592G>A	c.(3592-3594)Gat>Aat	p.D1198N	RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.D1244N|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.D1232N|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.D1278N	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	1278					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				CCCATACCATCGATATTTTGC	0.488000													4	74					0	0	1	0	0
HNRNPK	3190	broad.mit.edu	37	9	86586966	86586966	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:86586966C>G	ENST00000376263.3	-	11	1007	c.784G>C	c.(784-786)Gac>Cac	p.D262H	HNRNPK_ENST00000351839.3_Missense_Mutation_p.D262H|HNRNPK_ENST00000376264.2_Missense_Mutation_p.D262H|HNRNPK_ENST00000360384.5_Missense_Mutation_p.D262H|HNRNPK_ENST00000376281.4_Missense_Mutation_p.D262H	NM_031263.2	NP_112553.1	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	262	2 X 22 AA approximate repeats.|2 X 6 AA approximate repeats.|5 X 4 AA repeats of G-X-G-G.|Interaction with ZIK1 (By similarity).|Necessary for interaction with DDX1.|RNA-binding RGG-box.				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|stomach(1)	19						GGCATTCTGTCAAAACCACCT	0.532000													14	68					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160050867	160050867	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:160050867G>C	ENST00000263635.6	+	17	3079	c.2842G>C	c.(2842-2844)Gag>Cag	p.E948Q	TANC1_ENST00000454300.1_Missense_Mutation_p.E842Q	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	948						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						CCTTGGCCACGAGGAAGTTGT	0.557000													6	75					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31323636	31323636	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:31323636C>T	ENST00000269197.5	+	12	3824	c.3824C>T	c.(3823-3825)tCt>tTt	p.S1275F		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1275	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ACTACAATTTCTGCTTGTAAT	0.393000													5	77					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53207850	53207850	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:53207850G>C	ENST00000293774.4	-	1	485	c.215C>G	c.(214-216)tCt>tGt	p.S72C	KRT4_ENST00000551956.1_5'UTR			B4DRS2	B4DRS2_HUMAN	keratin 4	0						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CATGGCTGCAGAGAGCGAGCT	0.627000													17	33					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216271124	216271124	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:216271124C>T	ENST00000354785.4	-	19	3192	c.2823G>A	c.(2821-2823)gtG>gtA	p.V941V	FN1_ENST00000443816.1_Silent_p.V941V|FN1_ENST00000446046.1_Silent_p.V941V|FN1_ENST00000356005.4_Silent_p.V941V|FN1_ENST00000346544.3_Silent_p.V941V|FN1_ENST00000432072.2_Silent_p.V941V|FN1_ENST00000359671.1_Silent_p.V941V|FN1_ENST00000345488.5_Silent_p.V941V|FN1_ENST00000357009.2_Silent_p.V941V|FN1_ENST00000357867.4_Silent_p.V941V|FN1_ENST00000336916.4_Silent_p.V941V|FN1_ENST00000421182.1_Silent_p.V941V|FN1_ENST00000323926.6_Silent_p.V941V			P02751	FINC_HUMAN	fibronectin 1	941	Fibronectin type-III 4.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGACGGGGATCACATCCACAC	0.602000													6	24					0	0	1	0	0
CEP120	153241	broad.mit.edu	37	5	122717855	122717855	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:122717855C>T	ENST00000306467.5	-	14	2357	c.2053G>A	c.(2053-2055)Gag>Aag	p.E685K	CEP120_ENST00000306481.6_Missense_Mutation_p.E659K|CEP120_ENST00000328236.5_Missense_Mutation_p.E685K			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	685						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						TTCCATTCCTCTGCAAGAGCC	0.353000													5	65					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60505607	60505607	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:60505607C>A	ENST00000371201.3	-	5	836	c.729G>T	c.(727-729)aaG>aaT	p.K243N	C1orf87_ENST00000450089.2_Intron	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	243							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GAGAACCCCTCTTAGAAAATC	0.408000													21	122					4.35082e-09	4.60934e-09	1	1	0
SYTL2	54843	broad.mit.edu	37	11	85445719	85445719	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:85445719G>A	ENST00000316356.4	-	7	1217	c.653C>T	c.(652-654)tCa>tTa	p.S218L	SYTL2_ENST00000527523.1_Missense_Mutation_p.S169L|SYTL2_ENST00000389960.4_Missense_Mutation_p.S217L|SYTL2_ENST00000524452.1_Missense_Mutation_p.S217L|SYTL2_ENST00000528231.1_Missense_Mutation_p.S217L			Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	217					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		AGTCTGCTTTGATTTCTCTAA	0.368000													35	66					0	0	1	0	0
HIST1H2BE	8344	broad.mit.edu	37	6	26184092	26184092	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:26184092G>A	ENST00000356530.3	+	1	135	c.69G>A	c.(67-69)caG>caA	p.Q23Q		NM_003523.2	NP_003514.2	P62807	H2B1C_HUMAN	histone cluster 1, H2be	23					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			endometrium(1)|large_intestine(2)|lung(1)	4						CCAAGGCGCAGAAGAAGGACG	0.577000													59	114					0	0	1	0	0
DMC1	11144	broad.mit.edu	37	22	38916075	38916075	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:38916075C>T	ENST00000216024.2	-	14	1249	c.973G>A	c.(973-975)Gaa>Aaa	p.E325K	DMC1_ENST00000428462.2_Missense_Mutation_p.E270K	NM_007068.2	NP_008999.2	Q14565	DMC1_HUMAN	DNA meiotic recombinase 1	325					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11	Melanoma(58;0.0286)					AAGGTGGCTTCATTTTCAGGC	0.393000								Homologous recombination					21	73					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													6	35					0	0	1	0	0
CYP3A5	1577	broad.mit.edu	37	7	99247765	99247765	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:99247765G>C	ENST00000343703.5	-	13	1700	c.1314C>G	c.(1312-1314)ctC>ctG	p.L438L	CYP3A5_ENST00000339843.2_3'UTR|CYP3A5_ENST00000222982.4_Silent_p.L448L					cytochrome P450, family 3, subfamily A, polypeptide 5											NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)					TCATGTTCATGAGAGCAAACC	0.398000													9	170					0	0	1	0	0
SAMD11	148398	broad.mit.edu	37	1	878746	878746	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:878746G>C	ENST00000342066.3	+	12	1761	c.1678G>C	c.(1678-1680)Gag>Cag	p.E560Q		NM_152486.2	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	560	SAM.					nucleus				breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		TGGCTGTGGAGAGTACACTCG	0.657000													11	37					0	0	1	0	0
FAM46A	55603	broad.mit.edu	37	6	82459924	82459924	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:82459924C>G	ENST00000369754.3	-	3	1186	c.874G>C	c.(874-876)Gat>Cat	p.D292H	FAM46A_ENST00000369756.3_Missense_Mutation_p.D354H|FAM46A_ENST00000320172.6_Missense_Mutation_p.D273H			Q96IP4	FA46A_HUMAN	family with sequence similarity 46, member A	273										endometrium(2)|large_intestine(3)|lung(5)|skin(1)|urinary_tract(1)	12		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		CAAAGGTGATCAAAGGCTTCC	0.493000													15	68					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151262298	151262298	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:151262298G>A	ENST00000368879.2	+	6	2877	c.2779G>A	c.(2779-2781)Gaa>Aaa	p.E927K		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	927	Poly-Glu.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTCATCTTCAGAAGAGGAGGA	0.667000													3	5					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170959046	170959046	+	Silent	SNP	T	T	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:170959046T>C	ENST00000367759.4	+	11	1084	c.930T>C	c.(928-930)tgT>tgC	p.C310C	MROH9_ENST00000367758.3_Silent_p.C310C	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		ATAACAATTGTATGAAGGATG	0.423000													65	108					0	0	1	0	0
VSIG1	340547	broad.mit.edu	37	X	107319443	107319443	+	Silent	SNP	A	A	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:107319443A>G	ENST00000415430.3	+	7	1094	c.933A>G	c.(931-933)gaA>gaG	p.E311E	VSIG1_ENST00000217957.5_Silent_p.E275E	NM_001170553.1	NP_001164024.1	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	275						integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17						CCATCGCGGAACTTGAGTAAG	0.403000													47	18					0	0	1	0	0
UTP14C	9724	broad.mit.edu	37	13	52605165	52605165	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:52605165C>T	ENST00000521776.2	+	2	2958	c.2225C>T	c.(2224-2226)tCa>tTa	p.S742L		NM_021645.5	NP_067677.4	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	742					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				breast(4)|cervix(1)|endometrium(1)|large_intestine(10)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	32		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		CAGTCTTCCTCAAGGTCAGAC	0.478000													15	143					0	0	1	0	0
SLC17A6	57084	broad.mit.edu	37	11	22360119	22360119	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:22360119G>A	ENST00000263160.3	+	1	477	c.40G>A	c.(40-42)Gag>Aag	p.E14K		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	14					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity	p.E14K(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						CCCAGGAAAAGAGGGGCTAAA	0.438000													14	24					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40265139	40265139	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:40265139G>C	ENST00000263791.5	+	10	1627	c.1584G>C	c.(1582-1584)tgG>tgC	p.W528C	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.W528C|EIF2AK4_ENST00000559624.1_Missense_Mutation_p.W528C	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	528	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		AGGAAAGATGGAGTCCCCAGC	0.423000													5	86					0	0	1	0	0
BVES	11149	broad.mit.edu	37	6	105577271	105577271	+	Silent	SNP	A	A	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:105577271A>G	ENST00000314641.5	-	3	550	c.334T>C	c.(334-336)Tta>Cta	p.L112L	BVES_ENST00000446408.2_Silent_p.L112L|BVES_ENST00000336775.5_Silent_p.L112L	NM_001199563.1	NP_001186492.1	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance	112					epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity			NS(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|urinary_tract(1)	21		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				TTCTTGTATAAAAGATACGAC	0.348000													21	45					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49051521	49051521	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:49051521C>G	ENST00000395474.3	+	2	2924	c.2644C>G	c.(2644-2646)Cgg>Ggg	p.R882G	WDR6_ENST00000448293.1_Missense_Mutation_p.R801G|WDR6_ENST00000608424.1_Missense_Mutation_p.R852G|WDR6_ENST00000415265.2_Missense_Mutation_p.R300G	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	852					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		CAATCGGCATCGGATGGTTAA	0.592000											OREG0015565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	114					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8518022	8518022	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:8518022T>C	ENST00000381196.4	-	18	1912	c.1369A>G	c.(1369-1371)Atg>Gtg	p.M457V	PTPRD_ENST00000397606.3_Missense_Mutation_p.M447V|PTPRD_ENST00000537002.1_Missense_Mutation_p.M454V|PTPRD_ENST00000355233.5_Missense_Mutation_p.M457V|PTPRD_ENST00000397617.3_Missense_Mutation_p.M447V|PTPRD_ENST00000397611.3_Missense_Mutation_p.M454V|PTPRD_ENST00000360074.4_Missense_Mutation_p.M444V|PTPRD_ENST00000358503.5_Missense_Mutation_p.M444V|PTPRD_ENST00000486161.1_Missense_Mutation_p.M457V|PTPRD_ENST00000540109.1_Missense_Mutation_p.M457V|PTPRD_ENST00000356435.5_Missense_Mutation_p.M457V	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	457	Fibronectin type-III 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GTGGGATCCATTGTATAATAA	0.423000										TSP Lung(15;0.13)			61	125					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66456633	66456633	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:66456633G>A	ENST00000533211.1	-	30	6299	c.5968C>T	c.(5968-5970)Cag>Tag	p.Q1990*	SPTBN2_ENST00000529997.1_Nonsense_Mutation_p.Q1990*|SPTBN2_ENST00000309996.2_Nonsense_Mutation_p.Q1990*			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1990					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						GCCTGCAGCTGAGACAGCTTC	0.632000													3	14					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58604814	58604814	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:58604814G>A	ENST00000267485.7	-	2	1457	c.1263C>T	c.(1261-1263)ttC>ttT	p.F421F	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	421						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						TGGATTCCGTGAAGTCTCCCG	0.438000													12	75					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21123451	21123451	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:21123451G>A	ENST00000269228.5	-	14	2767	c.2213C>T	c.(2212-2214)tCa>tTa	p.S738L	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Missense_Mutation_p.S420L	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	738	SSD.				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AGAAAAGGATGACAGGAACAT	0.453000													11	151					0	0	1	0	0
APOBEC4	403314	broad.mit.edu	37	1	183616842	183616842	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:183616842C>T	ENST00000308641.4	-	2	1346	c.1075G>A	c.(1075-1077)Gaa>Aaa	p.E359K	APOBEC4_ENST00000481562.1_5'UTR|RGL1_ENST00000304685.4_Intron|RGL1_ENST00000536277.1_Intron	NM_203454.2	NP_982279.1	Q8WW27	ABEC4_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)	359					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(6)|skin(1)	21						TTCTTCTTTTCATCTGCCTCC	0.408000													21	162					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3148627	3148627	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:3148627C>G	ENST00000355072.5	+	25	3392	c.3247C>G	c.(3247-3249)Ctc>Gtc	p.L1083V		NM_002111.6	NP_002102	P42858	HD_HUMAN	huntingtin	1083					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CCCATTGGATCTCTCAGCCCA	0.502000													15	406					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54545425	54545425	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54545425C>G	ENST00000338372.2	-	6	688	c.513G>C	c.(511-513)aaG>aaC	p.K171N	VSTM1_ENST00000376626.1_Missense_Mutation_p.K140N|VSTM1_ENST00000425006.2_3'UTR|VSTM1_ENST00000366170.2_Missense_Mutation_p.K83N	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	171						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		GCATCTACCTCTTGGTGGATT	0.507000													31	146					0	0	1	0	0
AGPAT9	84803	broad.mit.edu	37	4	84457852	84457852	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:84457852C>T	ENST00000395226.2	+	2	295	c.77C>T	c.(76-78)tCg>tTg	p.S26L	AGPAT9_ENST00000264409.4_Missense_Mutation_p.S26L	NM_001256421.1	NP_001243350.1	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	26					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(3)	13		Hepatocellular(203;0.114)				CTTTTACCTTCGGTCTTCGGA	0.582000													5	24					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26793038	26793038	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:26793038G>C	ENST00000541819.2	-	10	1594	c.1492C>G	c.(1492-1494)Cta>Gta	p.L498V	GABRB3_ENST00000299267.4_Missense_Mutation_p.L442V|GABRB3_ENST00000311550.5_Missense_Mutation_p.L442V|GABRB3_ENST00000545868.1_Missense_Mutation_p.L357V|GABRB3_ENST00000400188.3_Missense_Mutation_p.L371V			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	442					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACATCGGTTAGATCAGGTATT	0.458000													33	38					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35331860	35331860	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:35331860G>A	ENST00000373347.1	-	12	3032	c.2764C>T	c.(2764-2766)Cgg>Tgg	p.R922W	DLGAP3_ENST00000235180.4_Missense_Mutation_p.R922W			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	922					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				CCCCGGCCCCGCAGGGGCTTC	0.716000											OREG0013353	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	11					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58604778	58604778	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:58604778G>C	ENST00000267485.7	-	2	1493	c.1299C>G	c.(1297-1299)ttC>ttG	p.F433L	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	433						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						TGGTTTCTAAGAAAAACAGGG	0.398000													13	93					0	0	1	0	0
MX2	4600	broad.mit.edu	37	21	42762521	42762521	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:42762521G>A	ENST00000330714.3	+	6	946	c.762G>A	c.(760-762)caG>caA	p.Q254Q	MX2_ENST00000543692.1_Intron	NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	254					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				AGTACATCCAGAGGCAGCAGA	0.557000													38	111					0	0	1	0	0
RNF8	9025	broad.mit.edu	37	6	37336788	37336788	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:37336788C>T	ENST00000373479.4	+	3	962	c.769C>T	c.(769-771)Ctg>Ttg	p.L257L	RNF8_ENST00000469731.1_Silent_p.L257L|RNF8_ENST00000479516.1_3'UTR	NM_003958.3|NM_183078.2	NP_003949.1|NP_898901.1	O76064	RNF8_HUMAN	ring finger protein 8, E3 ubiquitin protein ligase	257					cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	13						GTCCAGGATTCTGAGGCTCAA	0.433000													20	90					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32398671	32398671	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:32398671C>G	ENST00000357033.4	-	34	5007	c.4801G>C	c.(4801-4803)Gaa>Caa	p.E1601Q	DMD_ENST00000378677.2_Missense_Mutation_p.E1597Q	NM_000109.3|NM_004006.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1601	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGCATTCCTTCAACTGCTGAT	0.383000													6	125					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67477695	67477695	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:67477695G>A	ENST00000544246.1	-	3	3770	c.3079C>T	c.(3079-3081)Cag>Tag	p.Q1027*	PCDH9_ENST00000328454.5_Intron|PCDH9_ENST00000456367.1_Intron|PCDH9-AS2_ENST00000419371.2_RNA|PCDH9_ENST00000377865.2_Nonsense_Mutation_p.Q1027*	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1027					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GGACATTTCTGAGGAGTGACA	0.388000													4	69					0	0	1	0	0
LRAT	9227	broad.mit.edu	37	4	155665889	155665889	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:155665889C>G	ENST00000336356.3	+	2	664	c.411C>G	c.(409-411)ctC>ctG	p.L137L	LRAT_ENST00000507827.1_Silent_p.L137L	NM_004744.3	NP_004735.2	O95237	LRAT_HUMAN	lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)	137					response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)	16	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	AGGCACTGCTCAACGAGGAGG	0.577000													21	32					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24799114	24799114	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:24799114G>A	ENST00000310677.4	-	9	1282	c.1169C>T	c.(1168-1170)tCa>tTa	p.S390L	ADCY4_ENST00000418030.2_Missense_Mutation_p.S390L|ADCY4_ENST00000396747.3_Missense_Mutation_p.S83L|ADCY4_ENST00000554068.2_Missense_Mutation_p.S390L	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	390					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		GACATCATGTGACCAAACGTC	0.597000													20	112					0	0	1	0	0
ARMC6	93436	broad.mit.edu	37	19	19168416	19168416	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:19168416G>C	ENST00000535612.1	+	9	1917	c.1485G>C	c.(1483-1485)caG>caC	p.Q495H	ARMC6_ENST00000392336.3_Missense_Mutation_p.Q495H|ARMC6_ENST00000269932.6_Missense_Mutation_p.Q470H|ARMC6_ENST00000546344.1_Missense_Mutation_p.Q402H|ARMC6_ENST00000392335.2_Missense_Mutation_p.Q470H	NM_001199196.1	NP_001186125.1	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	495							protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|prostate(1)	14			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			GGACAGGCCAGAGGGGCAACC	0.652000													5	29					0	0	1	0	0
DUSP12	11266	broad.mit.edu	37	1	161726695	161726695	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:161726695G>T	ENST00000367943.4	+	6	1013	c.981G>T	c.(979-981)atG>atT	p.M327I		NM_007240.1	NP_009171.1	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	327					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|lung(1)	5	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			TGGATGAAATGAAAATATTGC	0.388000													16	81					4.14922e-12	4.47357e-12	1	1	0
C2CD3	26005	broad.mit.edu	37	11	73825601	73825601	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:73825601C>T	ENST00000334126.7	-	10	1784	c.1558G>A	c.(1558-1560)Gaa>Aaa	p.E520K	C2CD3_ENST00000313663.7_Missense_Mutation_p.E520K			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	520						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					TGGGCATCTTCTGGAGTTTCT	0.443000													19	83					0	0	1	0	0
TASP1	55617	broad.mit.edu	37	20	13514765	13514765	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:13514765G>A	ENST00000337743.4	-	9	819	c.699C>T	c.(697-699)gaC>gaT	p.D233D	TASP1_ENST00000480436.1_5'UTR|TASP1_ENST00000539805.1_Intron	NM_017714.2	NP_060184.2	Q9H6P5	TASP1_HUMAN	taspase, threonine aspartase, 1	233					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(11)|liver(1)|lung(11)|stomach(2)|urinary_tract(2)	31						CGCCTACCGTGTCCAAAGTGC	0.512000													35	109					0	0	1	0	0
IL17RE	132014	broad.mit.edu	37	3	9945786	9945786	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:9945786C>T	ENST00000454190.2	+	3	304	c.219C>T	c.(217-219)gtC>gtT	p.V73V	IL17RE_ENST00000295980.3_Silent_p.V73V|IL17RE_ENST00000421412.1_Silent_p.V106V|IL17RE_ENST00000383814.3_Silent_p.V73V	NM_001193380.1	NP_001180309.1	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E	73						cytoplasm|extracellular region|integral to membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(11)|skin(1)	21				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GTGTGCGAGTCTGGCACTGTT	0.532000													54	117					0	0	1	0	0
ICMT	23463	broad.mit.edu	37	1	6291999	6291999	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:6291999G>A	ENST00000343813.5	-	4	663	c.635C>T	c.(634-636)tCt>tTt	p.S212F		NM_012405.3	NP_036537.1	O60725	ICMT_HUMAN	isoprenylcysteine carboxyl methyltransferase	212					protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity			NS(1)|endometrium(2)	3	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;2.4e-22)|all_lung(118;2.65e-08)|Lung NSC(185;6.45e-07)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000688)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;5.52e-38)|GBM - Glioblastoma multiforme(13;6.51e-32)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;7.08e-08)|COAD - Colon adenocarcinoma(227;8.35e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		CCCGACGTAAGAAGGATGCCG	0.373000													22	47					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48313605	48313605	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:48313605C>G	ENST00000435803.1	+	17	4366	c.4342C>G	c.(4342-4344)Ctt>Gtt	p.L1448V		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1448					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AAAAAAACCTCTTTGTTCATC	0.264000													10	55					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926917	1926917	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:1926917G>A	ENST00000399161.2	-	10	1371	c.624C>T	c.(622-624)ctC>ctT	p.L208L	MYT1L_ENST00000428368.2_Silent_p.L208L	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	208					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CGATTTTGCCGAGGTTTAACA	0.423000													19	50					0	0	1	0	0
SFXN4	119559	broad.mit.edu	37	10	120923669	120923669	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:120923669C>G	ENST00000355697.2	-	2	170	c.151G>C	c.(151-153)Gat>Cat	p.D51H	SFXN4_ENST00000330036.6_Missense_Mutation_p.D51H|SFXN4_ENST00000461438.1_5'UTR	NM_213649.1	NP_998814.1	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	51					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	11		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		TTTGTAGGATCTAATAATTCT	0.318000													49	30					0	0	1	0	0
CSNK2A3	283106	broad.mit.edu	37	11	11374269	11374269	+	Missense_Mutation	SNP	A	A	G	rs2071460	by1000genomes	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:11374269A>G	ENST00000528848.2	-	1	635	c.398T>C	c.(397-399)aTt>aCt	p.I133T	GALNT18_ENST00000227756.4_Intron|RP11-567I13.1_ENST00000526867.1_RNA	NM_001256686.1	NP_001243615.1			casein kinase 2, alpha 3 polypeptide																		GTAAAATCGAATATCATAGTC	0.408000													5	89					0	0	1	0	0
IL2RA	3559	broad.mit.edu	37	10	6104059	6104059	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:6104059C>T	ENST00000379959.3	-	1	229	c.56G>A	c.(55-57)tGc>tAc	p.C19Y	IL2RA_ENST00000379954.1_Missense_Mutation_p.C19Y|IL2RA_ENST00000256876.6_Missense_Mutation_p.C19Y	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	19					cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	ACCTGCCTGGCAGCCAGGCAC	0.612000													9	87					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25321117	25321117	+	RNA	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:25321117G>A	ENST00000549804.2	+	0	1109				SNORD116-11_ENST00000383882.1_RNA																							TTGGAAAGTTGAACAAAATGA	0.433000													12	113					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56405156	56405156	+	Silent	SNP	G	G	A	rs148586326		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:56405156G>A	ENST00000355701.3	-	1	996	c.126C>T	c.(124-126)atC>atT	p.I42I	BZRAP1-AS1_ENST00000579527.1_RNA|BZRAP1_ENST00000343736.4_Silent_p.I42I|BZRAP1_ENST00000268893.6_Silent_p.I42I	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	42						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGTATCAGCGATGCTTGGGG	0.637000													4	31					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69964146	69964146	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:69964146C>T	ENST00000359154.2	+	13	1531	c.1430C>T	c.(1429-1431)cCg>cTg	p.P477L	WWP2_ENST00000568684.1_Missense_Mutation_p.P38L|WWP2_ENST00000542271.1_Missense_Mutation_p.P361L|WWP2_ENST00000356003.2_Missense_Mutation_p.P477L|WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000448661.1_Missense_Mutation_p.P477L	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	477	WW 4.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GATCCTCGCCCGGGGTTTGAG	0.597000											OREG0023910	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	10					0	0	1	0	0
ATP2A2	488	broad.mit.edu	37	12	110778732	110778732	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:110778732G>C	ENST00000395494.2	+	13	2512	c.1949G>C	c.(1948-1950)cGa>cCa	p.R650P	ATP2A2_ENST00000308664.6_Missense_Mutation_p.R677P|ATP2A2_ENST00000539276.2_Missense_Mutation_p.R677P			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	677					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						TGTTTTGCTCGAGTTGAACCC	0.498000													9	24					0	0	1	0	0
OSBPL7	114881	broad.mit.edu	37	17	45897592	45897592	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:45897592G>C	ENST00000007414.3	-	2	244	c.53C>G	c.(52-54)tCa>tGa	p.S18*	OSBPL7_ENST00000392507.3_Nonsense_Mutation_p.S18*	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	18					lipid transport		lipid binding			autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						GCTGGGCTTTGAGGACTGAGC	0.637000													4	24					0	0	1	0	0
CBX2	84733	broad.mit.edu	37	17	77755666	77755666	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:77755666G>T	ENST00000269399.5	+	4	396	c.354G>T	c.(352-354)caG>caT	p.Q118H	CBX2_ENST00000310942.4_Intron	NM_032647.3	NP_116036.1	Q14781	CBX2_HUMAN	chromobox homolog 2	0	Ser-rich.				cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGGGCAGGCAGAGGGAGGGTT	0.642000													6	51					3.59834e-05	3.71523e-05	1	1	0
TAF1B	9014	broad.mit.edu	37	2	10045054	10045054	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:10045054C>T	ENST00000263663.5	+	9	1062	c.874C>T	c.(874-876)Cgt>Tgt	p.R292C	TAF1B_ENST00000396242.3_Missense_Mutation_p.R37C	NM_005680.2	NP_005671	Q53T94	TAF1B_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	292			R -> H (in dbSNP:rs16867223).		termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AGATTTGCCTCGTTTTCCAGA	0.378000													8	136					0	0	1	0	0
HIST2H2AB	317772	broad.mit.edu	37	1	149859417	149859417	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:149859417G>C	ENST00000331128.3	-	1	49	c.50C>G	c.(49-51)tCg>tGg	p.S17W		NM_175065.2	NP_778235.1	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	17					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GGACGAGCGCGACTTGGCCTT	0.622000													20	102					0	0	1	0	0
INSC	387755	broad.mit.edu	37	11	15199878	15199878	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:15199878A>C	ENST00000379554.3	+	5	651	c.605A>C	c.(604-606)cAg>cCg	p.Q202P	INSC_ENST00000528567.1_Missense_Mutation_p.Q155P|INSC_ENST00000424273.1_Missense_Mutation_p.Q155P|INSC_ENST00000530161.1_Missense_Mutation_p.Q155P|INSC_ENST00000525218.1_Missense_Mutation_p.Q155P|INSC_ENST00000379556.3_Missense_Mutation_p.Q155P	NM_001031853.3	NP_001027024.3	Q1MX18	INSC_HUMAN	inscuteable homolog (Drosophila)	202					cell differentiation|nervous system development	cytoplasm	binding			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(3)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49						AGGTGCCTTCAGGTTGAGAAT	0.572000													31	15					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66386048	66386048	+	Silent	SNP	A	A	G	rs66995460		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:66386048A>G	ENST00000404260.3	+	6	1130	c.822A>G	c.(820-822)tcA>tcG	p.S274S	MAST4_ENST00000403666.1_Silent_p.S85S|MAST4_ENST00000490016.2_Silent_p.S85S|MAST4_ENST00000261569.7_Silent_p.S80S|MAST4_ENST00000403625.2_Silent_p.S274S|MAST4_ENST00000405643.1_Silent_p.S92S			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	274						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CCCATTTTTCATTTGCACGGA	0.443000													9	7					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518227	113518227	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:113518227C>T	ENST00000284601.3	-	4	2988	c.2920G>A	c.(2920-2922)Gaa>Aaa	p.E974K		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	974					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						GAAACTTCTTCAGGTTTAGAC	0.378000													45	76					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5969048	5969048	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:5969048C>T	ENST00000399933.3	-	3	1182	c.1183G>A	c.(1183-1185)Gaa>Aaa	p.E395K	KIAA2026_ENST00000381461.2_Missense_Mutation_p.E395K	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	395										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CCCAGTTTTTCAGCACAGTTA	0.418000													5	19					0	0	1	0	0
NAPSA	9476	broad.mit.edu	37	19	50864260	50864260	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:50864260C>T	ENST00000253719.2	-	5	814	c.606G>A	c.(604-606)ccG>ccA	p.P202P	NR1H2_ENST00000542413.1_Intron|NR1H2_ENST00000600978.1_Intron	NM_004851.1	NP_004842.1	O96009	NAPSA_HUMAN	napsin A aspartic peptidase	202					proteolysis	extracellular region	aspartic-type endopeptidase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		GTACATCCATCGGGGGCCGAA	0.532000													38	77					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139917811	139917811	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:139917811C>T	ENST00000297183.6	+	32	7493	c.7369C>T	c.(7369-7371)Cag>Tag	p.Q2457*	ANKHD1_ENST00000360839.2_Nonsense_Mutation_p.Q2457*|ANKHD1_ENST00000544120.1_Nonsense_Mutation_p.Q781*|ANKHD1-EIF4EBP3_ENST00000532219.1_Nonsense_Mutation_p.Q2457*	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATTTTTCATCAGCCTATGGC	0.408000													39	120					0	0	1	0	0
ZPBP2	124626	broad.mit.edu	37	17	38027764	38027764	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:38027764G>C	ENST00000377940.3	+	3	365	c.226G>C	c.(226-228)Gat>Cat	p.D76H	ZPBP2_ENST00000584588.1_Missense_Mutation_p.D98H|ZPBP2_ENST00000348931.4_Missense_Mutation_p.D98H	NM_198844.2	NP_942141.2	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2	98					binding of sperm to zona pellucida	extracellular region				kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			GATGGTGAAAGATTTTTTGGA	0.284000													17	131					0	0	1	0	0
HCCS	3052	broad.mit.edu	37	X	11133074	11133074	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:11133074G>C	ENST00000321143.4	+	3	422	c.220G>C	c.(220-222)Gag>Cag	p.E74Q	HCCS_ENST00000380762.4_Missense_Mutation_p.E74Q|HCCS_ENST00000380763.3_Missense_Mutation_p.E74Q	NM_001122608.2|NM_001171991.2|NM_005333.4	NP_001116080.1|NP_001165462.1|NP_005324.3	P53701	CCHL_HUMAN	holocytochrome c synthase	74					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)	7						CACTGCGGCTGAGAATAAGGA	0.493000													4	72					0	0	1	0	0
PLK3	1263	broad.mit.edu	37	1	45271270	45271270	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:45271270C>T	ENST00000372201.4	+	15	2100	c.1861C>T	c.(1861-1863)Cgg>Tgg	p.R621W	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	621	POLO box 2.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					TTCCCACCTTCGGCAGCTGGG	0.637000													8	181					0	0	1	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50471824	50471824	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:50471824C>A	ENST00000435965.1	-	3	498	c.325G>T	c.(325-327)Gag>Tag	p.E109*	CACNA2D2_ENST00000266039.3_Nonsense_Mutation_p.E109*|CACNA2D2_ENST00000479441.1_Nonsense_Mutation_p.E109*|CACNA2D2_ENST00000429770.1_Nonsense_Mutation_p.E109*|CACNA2D2_ENST00000487413.1_5'UTR|CACNA2D2_ENST00000360963.3_Nonsense_Mutation_p.E40*|CACNA2D2_ENST00000424201.2_Nonsense_Mutation_p.E109*|CACNA2D2_ENST00000395083.1_Nonsense_Mutation_p.E109*|CACNA2D2_ENST00000423994.2_Nonsense_Mutation_p.E109*			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	109					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	GGCTCATTCTCCTGTACCTCG	0.572000													5	112					0.014758	0.0149213	1	1	0
PTPRK	5796	broad.mit.edu	37	6	128411102	128411102	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:128411102C>T	ENST00000368227.3	-	8	1564	c.1198G>A	c.(1198-1200)Gaa>Aaa	p.E400K	PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000532331.1_Missense_Mutation_p.E400K|PTPRK_ENST00000368207.3_Missense_Mutation_p.E400K|PTPRK_ENST00000368226.4_Missense_Mutation_p.E400K|PTPRK_ENST00000368210.3_Missense_Mutation_p.E400K|PTPRK_ENST00000368213.5_Missense_Mutation_p.E400K|PTPRK_ENST00000368215.3_Missense_Mutation_p.E400K			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	400	Fibronectin type-III 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		GCCTGTATTTCAGCAATCTTT	0.383000													37	94					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74284010	74284010	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:74284010G>A	ENST00000295897.4	+	12	1723	c.1634G>A	c.(1633-1635)aGa>aAa	p.R545K	ALB_ENST00000503124.1_Missense_Mutation_p.R395K|ALB_ENST00000415165.2_Missense_Mutation_p.R353K|ALB_ENST00000401494.3_Missense_Mutation_p.R430K|ALB_ENST00000509063.1_Missense_Mutation_p.R545K|ALB_ENST00000505649.1_3'UTR	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	545	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	GAGAAGGAGAGACAAATCAAG	0.383000													20	39					0	0	1	0	0
GATA5	140628	broad.mit.edu	37	20	61040029	61040029	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:61040029C>A	ENST00000252997.2	-	7	1118	c.1057G>T	c.(1057-1059)Gac>Tac	p.D353Y		NM_080473.4	NP_536721.1	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	353					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			kidney(1)|lung(3)|ovary(1)|stomach(1)	6	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			GCAAGAGAGTCATCCTCCTGG	0.672000													14	24					6.72482e-11	7.18691e-11	1	1	0
SSH3	54961	broad.mit.edu	37	11	67075889	67075889	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:67075889G>C	ENST00000308127.4	+	10	1199	c.1021G>C	c.(1021-1023)Gag>Cag	p.E341Q	SSH3_ENST00000532181.1_3'UTR|SSH3_ENST00000308298.7_Intron|SSH3_ENST00000376757.5_Missense_Mutation_p.E341Q	NM_017857.3	NP_060327.3	Q8TE77	SSH3_HUMAN	slingshot protein phosphatase 3	341	Tyrosine-protein phosphatase.				regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCAGGGCTCAGAGTGGAACGC	0.657000													7	23					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153135920	153135920	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:153135920G>A	ENST00000370060.1	-	8	918	c.729C>T	c.(727-729)ctC>ctT	p.L243L	L1CAM_ENST00000538883.1_Silent_p.L245L|L1CAM_ENST00000361699.4_Silent_p.L243L|L1CAM_ENST00000370057.3_Silent_p.L243L|L1CAM_ENST00000543994.1_Silent_p.L245L|L1CAM_ENST00000361981.3_Silent_p.L238L|L1CAM_ENST00000370055.1_Silent_p.L238L	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	243	Ig-like C2-type 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGTGGGGAAGAGCAGGCGCG	0.632000													4	20					0	0	1	0	0
ZCWPW2	152098	broad.mit.edu	37	3	28454785	28454785	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:28454785G>A	ENST00000383768.2	+	3	414	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K	ZCWPW2_ENST00000421010.1_Missense_Mutation_p.E76K			Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	76							zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(6)|ovary(2)	17						AATTTCTGAAGAAGACTTCCC	0.388000													8	143					0	0	1	0	0
CHMP2A	27243	broad.mit.edu	37	19	59063424	59063424	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:59063424C>T	ENST00000600118.1	-	3	902	c.477G>A	c.(475-477)gaG>gaA	p.E159E	CHMP2A_ENST00000312547.2_Silent_p.E159E|CHMP2A_ENST00000601220.1_Silent_p.E159E			O43633	CHM2A_HUMAN	charged multivesicular body protein 2A	159	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	7		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CCCCATACCTCTCCTCTTCAT	0.517000													11	193					0	0	1	0	0
SLC7A9	11136	broad.mit.edu	37	19	33334854	33334854	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:33334854G>A	ENST00000023064.4	-	10	1172	c.981C>T	c.(979-981)ctC>ctT	p.L327L	SLC7A9_ENST00000590341.1_Silent_p.L327L|SLC7A9_ENST00000587772.1_Silent_p.L327L	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	327					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	CCACGTAAATGAGTCTGGAAA	0.577000													5	37					0	0	1	0	0
TRIM27	5987	broad.mit.edu	37	6	28872256	28872256	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:28872256C>T	ENST00000377199.3	-	8	1489	c.1133G>A	c.(1132-1134)gGa>gAa	p.G378E	TRIM27_ENST00000377194.3_Intron	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	378	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						GGCTTTATCTCCCACCTCTAC	0.532000			T	RET	papillary thyroid								16	75					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8484129	8484129	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:8484129C>T	ENST00000381196.4	-	27	3946	c.3403G>A	c.(3403-3405)Gag>Aag	p.E1135K	PTPRD_ENST00000397606.3_Missense_Mutation_p.E714K|PTPRD_ENST00000537002.1_Missense_Mutation_p.E721K|PTPRD_ENST00000355233.5_Missense_Mutation_p.E724K|PTPRD_ENST00000397617.3_Missense_Mutation_p.E714K|PTPRD_ENST00000397611.3_Missense_Mutation_p.E721K|PTPRD_ENST00000360074.4_Missense_Mutation_p.E1122K|PTPRD_ENST00000358503.5_Missense_Mutation_p.E1113K|PTPRD_ENST00000486161.1_Missense_Mutation_p.E724K|PTPRD_ENST00000540109.1_Missense_Mutation_p.E1135K|PTPRD_ENST00000356435.5_Missense_Mutation_p.E1135K	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1135					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTTATATTCTCATTTGCAGGT	0.383000										TSP Lung(15;0.13)			6	102					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170239053	170239053	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:170239053G>A	ENST00000518525.1	+	11	1578	c.1114G>A	c.(1114-1116)Gaa>Aaa	p.E372K	GABRP_ENST00000519385.1_3'UTR|GABRP_ENST00000265294.4_Missense_Mutation_p.E372K			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	372						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGCCAGCATTGAAATTTCCAG	0.413000													20	72					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179641476	179641476	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:179641476G>C	ENST00000589042.1	-	28	5339	c.5115C>G	c.(5113-5115)ttC>ttG	p.F1705L	TTN_ENST00000342992.6_Missense_Mutation_p.F1705L|TTN_ENST00000342175.6_Missense_Mutation_p.F1659L|TTN_ENST00000591111.1_Missense_Mutation_p.F1705L|TTN_ENST00000359218.5_Missense_Mutation_p.F1659L|TTN_ENST00000460472.2_Missense_Mutation_p.F1659L|TTN_ENST00000360870.5_Missense_Mutation_p.F1705L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1459	Ig-like 8.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTTTTCTTGAAAAATGGTT	0.483000													8	57					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42906092	42906092	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:42906092C>G	ENST00000244289.4	-	10	3379	c.3103G>C	c.(3103-3105)Gag>Cag	p.E1035Q	LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000599276.1_RNA|LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000593491.2_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	1035					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				TGGCGCGTCTCGCGGCACAGC	0.756000													2	3					0	0	1	0	0
MAVS	57506	broad.mit.edu	37	20	3842053	3842053	+	Translation_Start_Site	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3842053G>A	ENST00000416600.2	+	0	323				MAVS_ENST00000428216.2_Missense_Mutation_p.A123T|MAVS_ENST00000358134.6_Intron	NM_001206491.1	NP_001193420.1	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein						activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						CCCCACACCTGCTGCGGCCCA	0.627000													12	100					0	0	1	0	0
EFCAB11	90141	broad.mit.edu	37	14	90416473	90416473	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:90416473G>A	ENST00000316738.7	-	3	213	c.185C>T	c.(184-186)tCt>tTt	p.S62F	EFCAB11_ENST00000267544.9_5'UTR|EFCAB11_ENST00000555872.1_Missense_Mutation_p.S38F|RP11-33N16.3_ENST00000555070.1_RNA|EFCAB11_ENST00000556005.1_Missense_Mutation_p.S38F|EFCAB11_ENST00000538485.2_Missense_Mutation_p.S62F|EFCAB11_ENST00000556609.1_Missense_Mutation_p.S14F	NM_001284267.1|NM_145231.3	NP_001271196.1|NP_660274.1	Q9BUY7	EFC11_HUMAN	EF-hand calcium binding domain 11	62							calcium ion binding			large_intestine(1)|lung(1)	2						AGACATCACAGAATCCACTTC	0.318000													6	14					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885613	88885613	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:88885613G>A	ENST00000319675.3	-	1	683	c.587C>T	c.(586-588)gCg>gTg	p.A196V		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	196										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						AGAGTGATACGCGTGGATGCT	0.557000													42	77					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100395059	100395059	+	RNA	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:100395059G>C	ENST00000542585.1	+	0	8548				ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CGTGACCAGAGAGTGCATTTA	0.602000													24	39					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183267846	183267846	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:183267846C>A	ENST00000511685.1	+	3	398	c.275C>A	c.(274-276)gCa>gAa	p.A92E	TENM3_ENST00000406950.2_Missense_Mutation_p.A92E					teneurin transmembrane protein 3																		TGTGAACCAGCAACTCGAAGA	0.428000													17	17					5.03518e-11	5.39695e-11	1	1	0
PAPPA2	60676	broad.mit.edu	37	1	176681100	176681100	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:176681100G>A	ENST00000367662.3	+	12	4945	c.3781G>A	c.(3781-3783)Gat>Aat	p.D1261N		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1261					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GAAGAAAGAGGATGAGGTTTG	0.468000													6	78					0	0	1	0	0
SERPINF1	5176	broad.mit.edu	37	17	1678376	1678376	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:1678376C>T	ENST00000254722.4	+	6	831	c.668C>T	c.(667-669)tCc>tTc	p.S223F		NM_002615.5	NP_002606.3	P36955	PEDF_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	223					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	16						AAGTTTGACTCCAGAAAGACT	0.522000													4	79					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35614676	35614676	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:35614676G>C	ENST00000353139.5	-	14	2256	c.1775C>G	c.(1774-1776)tCt>tGt	p.S592C	ACACA_ENST00000360679.3_Missense_Mutation_p.S497C|ACACA_ENST00000335166.5_Missense_Mutation_p.S477C|ACACA_ENST00000394406.2_Missense_Mutation_p.S555C	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	555	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ACCAAACTGAGAATCAGCAAA	0.393000													11	63					0	0	1	0	0
AKAP8L	26993	broad.mit.edu	37	19	15508649	15508649	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:15508649G>A	ENST00000397410.5	-	10	1305	c.1175C>T	c.(1174-1176)tCt>tTt	p.S392F	AKAP8L_ENST00000595879.1_5'UTR|AKAP8L_ENST00000595465.2_Missense_Mutation_p.S331F	NM_014371.2	NP_055186.2	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like							cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11						TTTGCACAGAGAACACACAAA	0.547000													14	12					0	0	1	0	0
ERF	2077	broad.mit.edu	37	19	42753761	42753761	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:42753761G>T	ENST00000222329.4	-	4	660	c.503C>A	c.(502-504)tCt>tAt	p.S168Y	AC006486.9_ENST00000594664.1_Intron|ERF_ENST00000440177.2_Missense_Mutation_p.S93Y	NM_006494.2	NP_006485.2	P50548	ERF_HUMAN	Ets2 repressor factor	168	Poly-Ser.				cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	17		Prostate(69;0.00682)				GGAAGATGAAGATGAAGAGCA	0.657000													4	66					0.00909568	0.00922183	1	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43825236	43825236	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:43825236G>A	ENST00000389420.3	-	22	3159	c.3160C>T	c.(3160-3162)Cac>Tac	p.H1054Y	ADAMTS20_ENST00000395541.2_Missense_Mutation_p.H208Y|ADAMTS20_ENST00000553158.1_Missense_Mutation_p.H1054Y	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1054	TSP type-1 5.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCACTCAAGTGATCTACATTC	0.428000													63	40					0	0	1	0	0
CCHCR1	54535	broad.mit.edu	37	6	31116208	31116208	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:31116208C>T	ENST00000396268.3	-	10	1742	c.1554G>A	c.(1552-1554)ctG>ctA	p.L518L	CCHCR1_ENST00000376266.5_Silent_p.L429L|CCHCR1_ENST00000396263.2_Silent_p.L429L|CCHCR1_ENST00000451521.2_Silent_p.L482L	NM_001105563.1|NM_001105564.1	NP_001099033.1|NP_001099034.1	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1	429					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(13)|skin(1)	23						CCACAAGCCTCAGCTGCTCCT	0.617000													7	140					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	158282442	158282442	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:158282442C>T	ENST00000389413.3	-	2	251	c.148G>A	c.(148-150)Gag>Aag	p.E50K	PTPRN2_ENST00000389416.4_Intron|PTPRN2_ENST00000409483.1_Missense_Mutation_p.E50K|PTPRN2_ENST00000404321.2_Missense_Mutation_p.E73K|PTPRN2_ENST00000389418.4_Missense_Mutation_p.E50K	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	50						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		ACACAGGCCTCGGACGCTCCG	0.731000													4	5					0	0	1	0	0
AP1G1	164	broad.mit.edu	37	16	71799484	71799484	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:71799484C>G	ENST00000299980.4	-	7	1087	c.646G>C	c.(646-648)Gtg>Ctg	p.V216L	AP1G1_ENST00000393512.3_Missense_Mutation_p.V219L|AP1G1_ENST00000433195.2_Missense_Mutation_p.V239L|AP1G1_ENST00000423132.2_Missense_Mutation_p.V219L|AP1G1_ENST00000569748.1_Missense_Mutation_p.V216L	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit	216					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				AATTGGGGCACAAGCTGCAGA	0.408000													12	32					0	0	1	0	0
HNRNPK	3190	broad.mit.edu	37	9	86586835	86586835	+	Silent	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:86586835C>A	ENST00000376263.3	-	11	1138	c.915G>T	c.(913-915)cgG>cgT	p.R305R	HNRNPK_ENST00000351839.3_Silent_p.R305R|HNRNPK_ENST00000376264.2_Silent_p.R305R|HNRNPK_ENST00000360384.5_Silent_p.R305R|HNRNPK_ENST00000376281.4_Silent_p.R305R	NM_031263.2	NP_112553.1	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	305	2 X 22 AA approximate repeats.|2 X 6 AA approximate repeats.|5 X 4 AA repeats of G-X-G-G.|Interaction with ZIK1 (By similarity).				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|stomach(1)	19						GAGGAAGATTCCGAGCTCTGC	0.517000													13	100					3.27435e-08	3.4539e-08	1	1	0
WDR75	84128	broad.mit.edu	37	2	190338996	190338996	+	Missense_Mutation	SNP	G	G	A	rs116046757	byFrequency	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:190338996G>A	ENST00000314761.4	+	19	2194	c.2134G>A	c.(2134-2136)Gaa>Aaa	p.E712K		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	712						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			AAAACTAAACGAAACTTTAGA	0.363000													10	133					0	0	1	0	0
CPD	1362	broad.mit.edu	37	17	28749808	28749808	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:28749808C>G	ENST00000225719.4	+	5	1500	c.1424C>G	c.(1423-1425)tCa>tGa	p.S475*	CPD_ENST00000543464.2_Nonsense_Mutation_p.S228*	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	475	Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						GAGGCTGTATCAACTGCTAGC	0.448000													7	117					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235892949	235892949	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:235892949C>T	ENST00000389794.3	-	37	9227	c.9053G>A	c.(9052-9054)cGa>cAa	p.R3018Q	LYST_ENST00000389793.2_Missense_Mutation_p.R3018Q|LYST_ENST00000473037.1_5'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3018					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding	p.R3018Q(1)		NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GATGCATCTTCGATTCACTCT	0.338000													4	61					0	0	1	0	0
TMEM104	54868	broad.mit.edu	37	17	72832682	72832682	+	Silent	SNP	C	C	T	rs147463051	byFrequency	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:72832682C>T	ENST00000335464.5	+	10	1509	c.1347C>T	c.(1345-1347)acC>acT	p.T449T	TMEM104_ENST00000582773.1_Intron|TMEM104_ENST00000417024.2_Intron|TMEM104_ENST00000582330.1_Silent_p.T449T	NM_017728.3	NP_060198.3	Q8NE00	TM104_HUMAN	transmembrane protein 104	449						integral to membrane				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(1)	19	all_lung(278;0.23)					GCAGGGACACCCAGCTGGCCT	0.642000													4	48					0	0	1	0	0
ACBD7	414149	broad.mit.edu	37	10	15120588	15120588	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:15120588C>G	ENST00000356189.5	-	4	255	c.208G>C	c.(208-210)Gat>Cat	p.D70H	ACBD7_ENST00000496890.1_5'UTR	NM_001039844.2	NP_001034933.1	Q8N6N7	ACBD7_HUMAN	acyl-CoA binding domain containing 7	70	ACB.						fatty-acyl-CoA binding			endometrium(1)|lung(4)|prostate(1)	6						CTCGTCGCATCTTCCGTCGAC	0.363000													6	113					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117253519	117253519	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:117253519G>T	ENST00000278935.3	+	14	1732	c.1585G>T	c.(1585-1587)Gcc>Tcc	p.A529S	CEP164_ENST00000533706.1_3'UTR	NM_001271933.1|NM_014956.4	NP_001258862.1|NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	529	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		AAGGGAGCAGGCCCCAAGCCC	0.547000													5	114					0.217242	0.217838	1	1	0
IFIT2	3433	broad.mit.edu	37	10	91066692	91066692	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:91066692G>A	ENST00000371826.3	+	2	1148	c.979G>A	c.(979-981)Gat>Aat	p.D327N	LIPA_ENST00000487618.1_Intron|LIPA_ENST00000371837.1_Intron	NM_001547.4	NP_001538.4	P09913	IFIT2_HUMAN	interferon-induced protein with tetratricopeptide repeats 2	327					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|skin(1)	12		Colorectal(252;0.0161)				GAAGAAAGCTGATGAGGCCAA	0.418000													6	58					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	37948664	37948664	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:37948664C>T	ENST00000377707.3	-	5	1879	c.1314G>A	c.(1312-1314)caG>caA	p.Q438Q	RP11-613M10.9_ENST00000540557.1_3'UTR	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	438	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GCTTGCTGGTCTGGCTGTTCC	0.647000													7	68					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430591	43430591	+	RNA	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:43430591G>A	ENST00000406070.2	-	0	1083				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GATACTCACAGAGGACATTCA	0.517000													7	187					0	0	1	0	0
RPAP2	79871	broad.mit.edu	37	1	92799022	92799022	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:92799022G>C	ENST00000610020.1	+	9	1639	c.1530G>C	c.(1528-1530)ttG>ttC	p.L510F		NM_024813.2	NP_079089.2	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2							integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	22		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		TTGAAAAGTTGAGTAAAGTGT	0.333000													5	70					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39537620	39537620	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:39537620C>T	ENST00000265707.5	+	16	1741	c.1696C>T	c.(1696-1698)Caa>Taa	p.Q566*	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Nonsense_Mutation_p.Q542*	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	566	Cys-rich.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding	p.Q566*(1)		NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			AAGTGACGCTCAATCTACAGT	0.383000													7	91					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1367574	1367574	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:1367574C>G	ENST00000446702.2	+	9	1649	c.1022C>G	c.(1021-1023)gCt>gGt	p.A341G	CNTN6_ENST00000539053.1_Missense_Mutation_p.A269G|CNTN6_ENST00000350110.2_Missense_Mutation_p.A341G			Q9UQ52	CNTN6_HUMAN	contactin 6	341	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GAATGTAAAGCTAGTGGAAAG	0.398000													19	78					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766229	77766229	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:77766229C>T	ENST00000521891.2	+	10	7520	c.7072C>T	c.(7072-7074)Caa>Taa	p.Q2358*	ZFHX4_ENST00000455469.2_Nonsense_Mutation_p.Q2313*|ZFHX4_ENST00000518282.1_Nonsense_Mutation_p.Q2332*|ZFHX4_ENST00000050961.6_Nonsense_Mutation_p.Q2313*	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2313	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGCCACTGATCAAGTGGTATA	0.493000										HNSCC(33;0.089)			29	136					0	0	1	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65198192	65198192	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:65198192C>T	ENST00000247226.7	+	6	1103	c.795C>T	c.(793-795)ttC>ttT	p.F265F	PLEKHG3_ENST00000394691.1_Silent_p.F321F	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	321	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		GGACCTTTTTCCTCTTTGACA	0.567000													26	55					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75058822	75058822	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:75058822G>C	ENST00000401621.2	-	15	1685	c.1565C>G	c.(1564-1566)tCt>tGt	p.S522C	TTC18_ENST00000394865.1_Missense_Mutation_p.S522C|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000310715.3_Missense_Mutation_p.S522C|TTC18_ENST00000355577.3_5'UTR			Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	522							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					AATGGCTCTAGAAATATTCTT	0.428000													4	75					0	0	1	0	0
LPHN1	22859	broad.mit.edu	37	19	14273687	14273687	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:14273687G>T	ENST00000340736.6	-	6	1238	c.941C>A	c.(940-942)tCg>tAg	p.S314*	CTB-55O6.12_ENST00000592086.1_RNA|CTB-55O6.12_ENST00000588387.1_RNA|LPHN1_ENST00000361434.3_Nonsense_Mutation_p.S309*	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	314	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GTTGGATGCCGAGCGCTTGTC	0.627000													3	19					0.115264	0.115898	1	1	0
TFEC	22797	broad.mit.edu	37	7	115624399	115624399	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:115624399G>C	ENST00000265440.7	-	2	277	c.97C>G	c.(97-99)Ctg>Gtg	p.L33V	TFEC_ENST00000484212.1_Missense_Mutation_p.L123V|TFEC_ENST00000320239.7_Missense_Mutation_p.L33V|TFEC_ENST00000393485.1_Missense_Mutation_p.L33V	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC	33	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			TCACTGTCCAGAGTTGTGTGT	0.468000													32	148					0	0	1	0	0
CCR3	1232	broad.mit.edu	37	3	46306895	46306895	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:46306895C>G	ENST00000357422.2	+	4	789	c.246C>G	c.(244-246)ctC>ctG	p.L82L	CCR3_ENST00000545097.1_Silent_p.L103L|CCR3_ENST00000541018.1_Silent_p.L82L|CCR3_ENST00000395940.2_Silent_p.L82L|CCR3_ENST00000395942.2_Silent_p.L82L			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	82					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CGGACCTGCTCTTCCTCGTCA	0.498000													12	208					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3628001	3628001	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:3628001G>C	ENST00000325418.4	+	1	791	c.772G>C	c.(772-774)Gag>Cag	p.E258Q	ITGAE_ENST00000263087.4_Intron|ITGAE_ENST00000571185.1_5'UTR	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	258					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										TGAGGATTCTGAGTTTCGGGC	0.542000													14	70					0	0	1	0	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070607	32070607	+	RNA	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:32070607C>G	ENST00000566806.1	-	0	499																											GTGAAGGTCTCCTGCAAGGCT	0.557000													4	79					0	0	1	0	0
KLHL20	27252	broad.mit.edu	37	1	173703360	173703360	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:173703360G>A	ENST00000209884.4	+	3	668	c.532G>A	c.(532-534)Gac>Aac	p.D178N	KLHL20_ENST00000493170.1_3'UTR|KLHL20_ENST00000546011.1_Intron	NM_014458.3	NP_055273.2	Q9Y2M5	KLH20_HUMAN	kelch-like family member 20	178	BACK.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			breast(3)|endometrium(6)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|upper_aerodigestive_tract(1)	34						GGCTTTTGCTGACACACATTC	0.463000													6	80					0	0	1	0	0
RPL23A	6147	broad.mit.edu	37	17	27047838	27047838	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:27047838C>T	ENST00000422514.2	+	2	752	c.139C>T	c.(139-141)Cgg>Tgg	p.R47W	RPL23A_ENST00000472628.1_5'UTR|RPL23A_ENST00000394938.4_Missense_Mutation_p.R85W|RPL23A_ENST00000496182.1_5'UTR	NM_000984.5	NP_000975.2	P62750	RL23A_HUMAN	ribosomal protein L23a	47					cell proliferation|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	nucleotide binding|protein binding|rRNA binding|structural constituent of ribosome			endometrium(1)|lung(3)|ovary(1)	5	Lung NSC(42;0.00431)					ACCCACCTTCCGGCGGCCGAA	0.537000											OREG0024282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	49					0	0	1	0	0
NCOA4	8031	broad.mit.edu	37	10	51584673	51584673	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:51584673G>C	ENST00000452682.1	+	9	1072	c.820G>C	c.(820-822)Gaa>Caa	p.E274Q	NCOA4_ENST00000344348.6_Missense_Mutation_p.E258Q|NCOA4_ENST00000374082.1_Missense_Mutation_p.E258Q|NCOA4_ENST00000430396.2_Missense_Mutation_p.E158Q|NCOA4_ENST00000443446.1_Missense_Mutation_p.E258Q|NCOA4_ENST00000498586.1_3'UTR|NCOA4_ENST00000374087.4_Missense_Mutation_p.E258Q|NCOA4_ENST00000438493.1_Missense_Mutation_p.E274Q|NCOA4_ENST00000414907.2_Missense_Mutation_p.E92Q	NM_001145260.1	NP_001138732.1	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4	258					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|skin(1)	5						AAAGGGCTTAGAAAACTGGCT	0.383000			T	RET	papillary thyroid								21	107					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98209579	98209579	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:98209579C>T	ENST00000430669.2	-	23	4346	c.3761G>A	c.(3760-3762)aGa>aAa	p.R1254K	PTCH1_ENST00000437951.1_Missense_Mutation_p.R1254K|PTCH1_ENST00000429896.2_Missense_Mutation_p.R1169K|PTCH1_ENST00000375274.2_Missense_Mutation_p.R1319K|PTCH1_ENST00000421141.1_Missense_Mutation_p.R1169K|PTCH1_ENST00000331920.6_Missense_Mutation_p.R1320K|PTCH1_ENST00000418258.1_Missense_Mutation_p.R1169K			Q13635	PTC1_HUMAN	patched 1	1320					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AAAAGCGTCTCTGCGCGGTCT	0.667000													17	77					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5789126	5789126	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:5789126G>A	ENST00000328090.5	+	15	4367	c.3742G>A	c.(3742-3744)Gaa>Aaa	p.E1248K		NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	1248																	TCCAAACACTGAAAATATGAA	0.408000													48	83					0	0	1	0	0
PTAFR	5724	broad.mit.edu	37	1	28477482	28477482	+	Silent	SNP	G	G	T	rs143590918		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:28477482G>T	ENST00000373857.3	-	2	685	c.51C>A	c.(49-51)ctC>ctA	p.L17L	PTAFR_ENST00000539896.1_Silent_p.L17L|PTAFR_ENST00000305392.3_Silent_p.L17L	NM_000952.4|NM_001164722.2|NM_001164723.2	NP_000943.1|NP_001158194.1|NP_001158195.1	P25105	PTAFR_HUMAN	platelet-activating factor receptor	17					chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|stomach(1)	15		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		CAATCGGGAAGAGAGTGTATC	0.527000													8	49					0.000673444	0.000687552	1	1	0
KIDINS220	57498	broad.mit.edu	37	2	8870993	8870993	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:8870993G>A	ENST00000256707.3	-	30	5354	c.5173C>T	c.(5173-5175)Cag>Tag	p.Q1725*	KIDINS220_ENST00000473731.1_Nonsense_Mutation_p.Q1706*|KIDINS220_ENST00000427284.1_Nonsense_Mutation_p.Q1706*|KIDINS220_ENST00000418530.1_Nonsense_Mutation_p.Q1626*	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1725					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TTCTCATTCTGAATAGTGGTT	0.463000													19	61					0	0	1	0	0
DPRX	503834	broad.mit.edu	37	19	54139992	54139992	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54139992G>C	ENST00000376650.1	+	3	377	c.326G>C	c.(325-327)aGa>aCa	p.R109T		NM_001012728.1	NP_001012746.1	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	109						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R109I(1)		endometrium(4)|large_intestine(1)|lung(7)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		ACACTACCCAGATTGCCCAAC	0.542000													44	81					0	0	1	0	0
PSMC1	5700	broad.mit.edu	37	14	90735763	90735763	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:90735763G>C	ENST00000261303.8	+	9	1007	c.904G>C	c.(904-906)Gag>Cag	p.E302Q	PSMC1_ENST00000543772.2_Missense_Mutation_p.E229Q	NM_002802.2	NP_002793.2	P62191	PRS4_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 1	302					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			endometrium(2)|kidney(2)|upper_aerodigestive_tract(2)	6		all_cancers(154;0.142)		COAD - Colon adenocarcinoma(157;0.21)		TTCTGGTGGTGAGAGAGAAAT	0.418000													13	77					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72956777	72956777	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:72956777G>C	ENST00000261180.4	+	9	1960	c.1864G>C	c.(1864-1866)Gat>Cat	p.D622H	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	622					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TTTTATCTATGATATCAGTGC	0.323000													58	41					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163230025	163230025	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:163230025C>T	ENST00000332142.5	-	15	3378	c.3279G>A	c.(3277-3279)ccG>ccA	p.P1093P		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	1093					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TGGATGCTTCCGGTTGACTGG	0.493000													6	113					0	0	1	0	0
ENTHD1	150350	broad.mit.edu	37	22	40139834	40139834	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:40139834C>T	ENST00000325157.6	-	7	1924	c.1674G>A	c.(1672-1674)gcG>gcA	p.A558A		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	558										breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					ATCTAGCGATCGCACGTTTTA	0.413000													7	60					0	0	1	0	0
ELOVL3	83401	broad.mit.edu	37	10	103987407	103987407	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:103987407G>A	ENST00000370005.3	+	2	347	c.126G>A	c.(124-126)ctG>ctA	p.L42L		NM_152310.1	NP_689523.1	Q9HB03	ELOV3_HUMAN	ELOVL fatty acid elongase 3	42					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			breast(2)|lung(10)|ovary(2)|prostate(1)|skin(1)	16		Colorectal(252;0.207)		Epithelial(162;4.47e-08)|all cancers(201;7.96e-07)		CCATAGCCCTGATCTACCTGG	0.557000													4	78					0	0	1	0	0
ATP1B2	482	broad.mit.edu	37	17	7557505	7557505	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:7557505C>G	ENST00000250111.4	+	4	889	c.482C>G	c.(481-483)tCc>tGc	p.S161C		NM_001678.3	NP_001669.3	P14415	AT1B2_HUMAN	ATPase, Na+/K+ transporting, beta 2 polypeptide	161					ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|pancreas(1)	10		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		GGCAACTGCTCCGGCATTGGG	0.562000													45	214					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111862083	111862083	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:111862083G>A	ENST00000369740.1	+	11	1273	c.1170G>A	c.(1168-1170)caG>caA	p.Q390Q	CHIA_ENST00000451398.2_Silent_p.Q229Q|CHIA_ENST00000483391.1_Silent_p.Q229Q|CHIA_ENST00000430615.1_Silent_p.Q282Q|CHIA_ENST00000353665.6_Silent_p.Q229Q|RP5-1125M8.2_ENST00000426321.1_RNA|CHIA_ENST00000343320.6_Silent_p.Q390Q	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	390					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		TCGGCCTGCAGAGTGCAAGTA	0.542000													24	29					0	0	1	0	0
MAP2K6	5608	broad.mit.edu	37	17	67519677	67519677	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:67519677C>T	ENST00000590474.1	+	8	845	c.558C>T	c.(556-558)ctC>ctT	p.L186L	MAP2K6_ENST00000589647.1_Silent_p.L130L	NM_002758.3	NP_002749.2	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	186	Protein kinase.				activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	20	Breast(10;6.05e-10)					CTAATGTACTCATCAATGCTC	0.448000													75	136					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53607319	53607319	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:53607319C>T	ENST00000425354.2	-	8	1466	c.979G>A	c.(979-981)Gag>Aag	p.E327K	RARG_ENST00000394426.1_Missense_Mutation_p.E327K|RARG_ENST00000338561.5_Missense_Mutation_p.E316K|RARG_ENST00000543726.1_Missense_Mutation_p.E305K|RARG_ENST00000543762.1_5'UTR|RARG_ENST00000327550.3_Missense_Mutation_p.E255K	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	327	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	AGCCCTGTCTCGGTGTCATCC	0.647000											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	17					0	0	1	0	0
MED15	51586	broad.mit.edu	37	22	20920999	20920999	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:20920999G>C	ENST00000263205.7	+	7	1005	c.936G>C	c.(934-936)caG>caC	p.Q312H	MED15_ENST00000541476.1_Missense_Mutation_p.Q286H|MED15_ENST00000542773.1_Missense_Mutation_p.Q117H|MED15_ENST00000425759.2_Missense_Mutation_p.Q201H|MED15_ENST00000478831.1_3'UTR|MED15_ENST00000382974.2_Missense_Mutation_p.Q241H|MED15_ENST00000406969.1_Missense_Mutation_p.Q286H|MED15_ENST00000292733.7_Missense_Mutation_p.Q312H	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	312	Pro-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			CAGTTGCTCAGAACCAACCAT	0.612000													7	110					0	0	1	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130392177	130392177	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:130392177G>C	ENST00000529410.1	+	15	1628	c.1149G>C	c.(1147-1149)aaG>aaC	p.K383N	L3MBTL3_ENST00000533560.1_Missense_Mutation_p.K358N|L3MBTL3_ENST00000361794.2_Missense_Mutation_p.K383N|L3MBTL3_ENST00000526019.1_Missense_Mutation_p.K358N|L3MBTL3_ENST00000368136.2_Missense_Mutation_p.K383N|L3MBTL3_ENST00000368139.2_Missense_Mutation_p.K358N			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	383					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		TAGACAAAAAGAATCCCTCAT	0.423000													59	289					0	0	1	0	0
GNAL	2774	broad.mit.edu	37	18	11876640	11876640	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:11876640G>A	ENST00000334049.6	+	11	1791	c.1183G>A	c.(1183-1185)Gat>Aat	p.D395N	GNAL_ENST00000423027.3_Missense_Mutation_p.D318N|GNAL_ENST00000269162.5_Missense_Mutation_p.D318N|GNAL_ENST00000535121.1_Missense_Mutation_p.D318N|GNAL_ENST00000602628.1_Missense_Mutation_p.D111N	NM_182978.3	NP_892023.1	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	318					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(4)|ovary(1)	12						TGCAGGAGAAGATCCCAAAGT	0.358000													10	132					0	0	1	0	0
CHAMP1	283489	broad.mit.edu	37	13	115090645	115090645	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:115090645C>T	ENST00000361283.1	+	3	1637	c.1328C>T	c.(1327-1329)tCa>tTa	p.S443L		NM_001164144.1|NM_001164145.1|NM_032436.2	NP_001157616.1|NP_001157617.1|NP_115812.1	Q96JM3	ZN828_HUMAN	chromosome alignment maintaining phosphoprotein 1	443	Mediates interaction with MAD2L2.|Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding										AGAAAACCCTCAGGGTCACCA	0.537000													72	151					0	0	1	0	0
ADPRHL1	113622	broad.mit.edu	37	13	114077230	114077230	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:114077230G>A	ENST00000356501.4	-	7	901	c.726C>T	c.(724-726)ctC>ctT	p.L242L	ADPRHL1_ENST00000375418.3_Silent_p.L324L	NM_199162.1	NP_954631.1	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1	324					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	11	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			CTTTGGGAACGAGGTCCAGGC	0.617000													6	83					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80529917	80529917	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:80529917G>A	ENST00000295057.3	-	2	1684	c.1028C>T	c.(1027-1029)gCc>gTc	p.A343V	CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000361291.4_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.A343V|CTNNA2_ENST00000466387.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	343	LRRCT.					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						CTCCGGGCTGGCGCACTGCAA	0.677000										HNSCC(69;0.2)			8	13					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197654765	197654765	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:197654765G>A	ENST00000263956.3	-	5	654	c.565C>T	c.(565-567)Cta>Tta	p.L189L	GTF3C3_ENST00000409364.3_Silent_p.L189L|GTF3C3_ENST00000470386.1_5'UTR	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	189						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						ATCATGGCTAGAGTAGAGAAT	0.403000													11	54					0	0	1	0	0
MAPK3	5595	broad.mit.edu	37	16	30128229	30128229	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30128229C>T	ENST00000484663.1	-	6	1794	c.661G>A	c.(661-663)Gac>Aac	p.D221N	MAPK3_ENST00000403394.1_Missense_Mutation_p.D335N|MAPK3_ENST00000395199.3_Missense_Mutation_p.D335N|MAPK3_ENST00000322266.5_Missense_Mutation_p.D291N|MAPK3_ENST00000395200.1_Missense_Mutation_p.D267N|MAPK3_ENST00000263025.4_Missense_Mutation_p.D335N|MAPK3_ENST00000395202.1_Missense_Mutation_p.D291N			P27361	MK03_HUMAN	mitogen-activated protein kinase 3	335	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding									Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	TCCGTCGGGTCATAGTACTGC	0.627000													16	135					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98581089	98581089	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:98581089C>T	ENST00000359863.4	+	59	9217	c.9008C>T	c.(9007-9009)cCg>cTg	p.P3003L	TRRAP_ENST00000355540.3_Intron|TRRAP_ENST00000446306.3_Intron	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3003	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			cagggtaaaccgacctggtcc	0.507000													22	20					0	0	1	0	0
TAF7L	54457	broad.mit.edu	37	X	100542501	100542501	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:100542501C>T	ENST00000372907.3	-	2	300	c.289G>A	c.(289-291)Gaa>Aaa	p.E97K	TAF7L_ENST00000324762.6_Missense_Mutation_p.E11K|TAF7L_ENST00000356784.1_Missense_Mutation_p.E11K|TAF7L_ENST00000372905.2_Missense_Mutation_p.E11K	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	97					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						TTCTCAACTTCATCAGGAACT	0.348000													4	31					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65412521	65412521	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:65412521C>T	ENST00000394224.3	+	5	1376	c.1080C>T	c.(1078-1080)ttC>ttT	p.F360F	SIPA1_ENST00000534313.1_Silent_p.F360F|SIPA1_ENST00000394227.3_Silent_p.F360F|SIPA1_ENST00000527525.1_Silent_p.F360F	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	360	Rap-GAP.				cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						GACCGGCCTTCATGCAGTTTC	0.622000													25	107					0	0	1	0	0
GLUD2	2747	broad.mit.edu	37	X	120181908	120181908	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:120181908C>T	ENST00000328078.1	+	1	447	c.370C>T	c.(370-372)Cgc>Tgc	p.R124C		NM_012084.3	NP_036216.2	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	124					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCCCATCCGGCGCGACGACGG	0.642000													18	24					0	0	1	0	0
RRAS	6237	broad.mit.edu	37	19	50138855	50138855	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:50138855C>T	ENST00000246792.3	-	6	737	c.635G>A	c.(634-636)gGc>gAc	p.G212D		NM_006270.3	NP_006261.1	P10301	RRAS_HUMAN	related RAS viral (r-ras) oncogene homolog	212					axon guidance|Ras protein signal transduction|synaptic transmission	intracellular|plasma membrane	GDP binding|GTP binding|GTPase activity|protein binding			endometrium(1)|kidney(1)|lung(2)|ovary(2)	6				OV - Ovarian serous cystadenocarcinoma(262;0.00114)|GBM - Glioblastoma multiforme(134;0.0206)		GCAGGGGCAGCCCCCGCCCTT	0.617000													50	72					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51219704	51219704	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:51219704A>G	ENST00000293441.1	-	2	305	c.287T>C	c.(286-288)aTc>aCc	p.I96T	SHANK1_ENST00000391814.1_Missense_Mutation_p.I96T|SHANK1_ENST00000359082.3_Missense_Mutation_p.I96T	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	96					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GGCCGTCCAGATGGTGGCATC	0.637000													20	45					0	0	1	0	0
LUZP2	338645	broad.mit.edu	37	11	24759813	24759813	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:24759813G>A	ENST00000533227.1	+	4	327	c.40G>A	c.(40-42)Gag>Aag	p.E14K	LUZP2_ENST00000531187.1_3'UTR|LUZP2_ENST00000336930.6_Missense_Mutation_p.E100K	NM_001009909.3|NM_001252008.1	NP_001009909.2|NP_001238937.1	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2	100						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						TCAGCTTAAGGAGACATCAGA	0.363000													6	20					0	0	1	0	0
RIN1	9610	broad.mit.edu	37	11	66100867	66100867	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:66100867C>T	ENST00000311320.4	-	9	1863	c.1737G>A	c.(1735-1737)ctG>ctA	p.L579L	RIN1_ENST00000530056.1_Silent_p.L413L|RIN1_ENST00000424433.2_Silent_p.L474L|RIN1_ENST00000524804.1_5'UTR	NM_004292.2	NP_004283.2	Q13671	RIN1_HUMAN	Ras and Rab interactor 1	579	Ras and 14-3-3 protein binding region.|VPS9.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(1)	14						AGAGGCTGGTCAGGTAGTAGC	0.672000													3	29					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62237176	62237176	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:62237176C>T	ENST00000371158.2	+	6	712	c.598C>T	c.(598-600)Cag>Tag	p.Q200*	INADL_ENST00000316485.6_Nonsense_Mutation_p.Q200*	NM_176877.2	NP_795352	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	200	PDZ 1.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CATTTCCCATCAGCAAGCAAT	0.373000													5	59					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10335485	10335485	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:10335485G>C	ENST00000377086.1	+	11	1084		c.e11-1		KIF1B_ENST00000263934.6_Splice_Site|KIF1B_ENST00000377093.4_Splice_Site|KIF1B_ENST00000377083.1_Splice_Site|KIF1B_ENST00000377081.1_Splice_Site			O60333	KIF1B_HUMAN	kinesin family member 1B						anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TCCTTTAATAGAGTAAAAAGA	0.323000													11	66					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132445298	132445298	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:132445298C>T	ENST00000333577.4	+	2	243	c.134C>T	c.(133-135)tCa>tTa	p.S45L	EP400_ENST00000332482.4_Missense_Mutation_p.S45L|EP400_ENST00000389562.2_Missense_Mutation_p.S45L|EP400_ENST00000330386.6_Missense_Mutation_p.S45L|EP400_ENST00000389561.2_Missense_Mutation_p.S45L			Q96L91	EP400_HUMAN	E1A binding protein p400	45					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TTCGCTCCCTCAGCAAGCCCG	0.652000													16	12					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75097549	75097549	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:75097549G>C	ENST00000326665.5	-	7	885	c.667C>G	c.(667-669)Caa>Gaa	p.Q223E	C1orf173_ENST00000420661.2_Missense_Mutation_p.Q26E	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	223										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTTGGAAGTTGATATGAATTC	0.403000													37	48					0	0	1	0	0
CD2AP	23607	broad.mit.edu	37	6	47563717	47563717	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:47563717C>G	ENST00000359314.5	+	12	1685	c.1229C>G	c.(1228-1230)cCa>cGa	p.P410R		NM_012120.2	NP_036252.1	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	410	Pro-rich.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton	p.P410Q(1)		kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	20			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			ACAGTGTACCCAAAGCGACCT	0.423000													29	176					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151860518	151860518	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:151860518G>A	ENST00000355193.2	-	43	10362	c.10144C>T	c.(10144-10146)Cgg>Tgg	p.R3382W	KMT2C_ENST00000262189.6_Missense_Mutation_p.R3382W					lysine (K)-specific methyltransferase 2C																		AATTCTACCCGAGGTGGTGGT	0.458000													63	108					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045216	87045216	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:87045216G>A	ENST00000370563.3	+	13	2344	c.2302G>A	c.(2302-2304)Gat>Aat	p.D768N	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	768						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AGTTCATGAGGATAAGATTAT	0.423000													7	170					0	0	1	0	0
TIGD4	201798	broad.mit.edu	37	4	153691640	153691640	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:153691640C>A	ENST00000304337.2	-	2	1337	c.517G>T	c.(517-519)Gat>Tat	p.D173Y		NM_145720.3	NP_663772.1	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	173					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			breast(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.093)					GGATGATAATCATTTAAATAA	0.353000													34	72					8.88839e-20	9.72667e-20	1	1	0
OSBPL7	114881	broad.mit.edu	37	17	45897373	45897373	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:45897373G>A	ENST00000007414.3	-	3	356	c.165C>T	c.(163-165)ctC>ctT	p.L55L	OSBPL7_ENST00000392507.3_Silent_p.L55L	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	55	PH.				lipid transport		lipid binding			autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						TCCTCTTCTTGAGCAGGTGAC	0.652000													3	24					0	0	1	0	0
TACR1	6869	broad.mit.edu	37	2	75280808	75280808	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:75280808C>T	ENST00000305249.5	-	3	1424	c.659G>A	c.(658-660)gGa>gAa	p.G220E	TACR1_ENST00000409848.3_Missense_Mutation_p.G220E	NM_001058.3	NP_001049.1	P25103	NK1R_HUMAN	tachykinin receptor 1						activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(8)|ovary(1)|skin(1)	24					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	TAGTGTGATTCCCACTACGGT	0.552000											OREG0014726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	44					0	0	1	0	0
DLL4	54567	broad.mit.edu	37	15	41228778	41228778	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:41228778C>T	ENST00000249749.5	+	9	1869	c.1593C>T	c.(1591-1593)gcC>gcT	p.A531A		NM_019074.3	NP_061947.1	Q9NR61	DLL4_HUMAN	delta-like 4 (Drosophila)	531					blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(3)|large_intestine(1)	4		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CCTGGGTGGCCGTCTCGCTGG	0.672000													8	10					0	0	1	0	0
AKT1	207	broad.mit.edu	37	14	105243078	105243078	+	Silent	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:105243078G>T	ENST00000554581.1	-	3	1685	c.205C>A	c.(205-207)Cgg>Agg	p.R69R	AKT1_ENST00000349310.3_Silent_p.R69R|AKT1_ENST00000554848.1_Silent_p.R69R|AKT1_ENST00000402615.2_Silent_p.R69R|AKT1_ENST00000407796.2_Silent_p.R69R|AKT1_ENST00000555528.1_Silent_p.R69R|AKT1_ENST00000544168.1_Silent_p.R7R			P31749	AKT1_HUMAN	v-akt murine thymoma viral oncogene homolog 1	69	PH.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			NS(3)|breast(97)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(7)|lung(10)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|thyroid(10)|urinary_tract(15)	176		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	GTGTTGGGCCGGGGCCGCTCC	0.672000		1	Mis		"""breast, colorectal, ovarian, NSCLC"""								14	35					6.72482e-11	7.18691e-11	1	1	0
MPL	4352	broad.mit.edu	37	1	43805111	43805111	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:43805111G>A	ENST00000372470.3	+	4	603	c.561G>A	c.(559-561)ctG>ctA	p.L187L	MPL_ENST00000413998.2_Silent_p.L187L	NM_005373.2	NP_005364.1	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	187	Fibronectin type-III 1.				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(551)|large_intestine(3)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	567	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCATACAGCTGATTGCCACAG	0.577000			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						41	75					0	0	1	0	0
STXBP3	6814	broad.mit.edu	37	1	109339276	109339276	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:109339276G>A	ENST00000370008.3	+	15	1334	c.1284G>A	c.(1282-1284)caG>caA	p.Q428Q		NM_007269.2	NP_009200.2	O00186	STXB3_HUMAN	syntaxin binding protein 3	428					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(3)|urinary_tract(1)	13		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		GGTTGATCCAGAATGTAAAGA	0.353000													6	62					0	0	1	0	0
DLGAP5	9787	broad.mit.edu	37	14	55618550	55618550	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:55618550C>G	ENST00000247191.2	-	17	2447	c.2231G>C	c.(2230-2232)gGa>gCa	p.G744A	DLGAP5_ENST00000395425.2_Missense_Mutation_p.G744A	NM_014750.4	NP_055565.3	Q15398	DLGP5_HUMAN	discs, large (Drosophila) homolog-associated protein 5	744					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			biliary_tract(1)|breast(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	44						ATCTGAAATTCCTTCTTTTTT	0.368000													16	67					0	0	1	0	0
C3orf36	80111	broad.mit.edu	37	3	133647541	133647541	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:133647541G>C	ENST00000408895.2	-	1	1115	c.107C>G	c.(106-108)tCt>tGt	p.S36C		NM_025041.2	NP_079317.2	Q3SXR2	CC036_HUMAN	chromosome 3 open reading frame 36	36										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	6						TGAGGGGGCAGAGAGACACGT	0.607000													12	50					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115395213	115395213	+	Silent	SNP	T	T	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:115395213T>C	ENST00000393780.3	+	3	960	c.492T>C	c.(490-492)ccT>ccC	p.P164P	GAP43_ENST00000305124.6_Silent_p.P128P	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	128					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		CCCAGGCTCCTGCATCCTCAG	0.602000													21	35					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88583124	88583124	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:88583124C>T	ENST00000418177.2	-	3	1228	c.861G>A	c.(859-861)ctG>ctA	p.L287L	GRM5_ENST00000305447.4_Silent_p.L287L|GRM5_ENST00000305432.5_Silent_p.L287L|GRM5_ENST00000455756.2_Silent_p.L287L|GRM5_ENST00000393297.1_Silent_p.L287L			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	287					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TCATGGCCATCAGCAGACCTC	0.517000													35	50					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70359471	70359471	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:70359471G>C	ENST00000305107.6	-	2	856	c.810C>G	c.(808-810)ctC>ctG	p.L270L	UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000512583.1_Silent_p.L270L|UGT2B4_ENST00000381096.3_Silent_p.L134L	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	270					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						CATTTGGTAAGAGTGGGTGAG	0.433000													8	146					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1414637	1414637	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:1414637G>C	ENST00000446702.2	+	14	2411	c.1784G>C	c.(1783-1785)aGa>aCa	p.R595T	CNTN6_ENST00000539053.1_Missense_Mutation_p.R523T|CNTN6_ENST00000350110.2_Missense_Mutation_p.R595T			Q9UQ52	CNTN6_HUMAN	contactin 6	595					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		ATCATTGTTAGAGGTAAGCAT	0.353000													7	97					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2832056	2832056	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:2832056C>G	ENST00000602557.1	-	57	9215	c.8660G>C	c.(8659-8661)aGa>aCa	p.R2887T	CSMD1_ENST00000537824.1_Missense_Mutation_p.R2886T|CSMD1_ENST00000602723.1_Missense_Mutation_p.R2829T|CSMD1_ENST00000400186.3_Missense_Mutation_p.R2829T|CSMD1_ENST00000542608.1_Missense_Mutation_p.R2828T|CSMD1_ENST00000520002.1_Missense_Mutation_p.R2887T			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2887	Sushi 21.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCGCTCCCTCTGCAGGAGTA	0.597000													12	16					0	0	1	0	0
ARPC3	10094	broad.mit.edu	37	12	110874486	110874486	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:110874486G>A	ENST00000228825.7	-	5	401	c.255C>T	c.(253-255)tgC>tgT	p.C85C	RP11-478C19.2_ENST00000550231.1_RNA	NM_001278556.1|NM_005719.2	NP_001265485.1|NP_005710.1	O15145	ARPC3_HUMAN	actin related protein 2/3 complex, subunit 3, 21kDa	85					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			lung(1)|ovary(1)	2						TTTTGGAATTGCACTGGaaaa	0.368000													7	27					0	0	1	0	0
STRBP	55342	broad.mit.edu	37	9	125910117	125910117	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:125910117C>A	ENST00000447404.2	-	11	1382	c.1078G>T	c.(1078-1080)Gaa>Taa	p.E360*	STRBP_ENST00000348403.5_Nonsense_Mutation_p.E360*|STRBP_ENST00000360998.3_Nonsense_Mutation_p.E346*			Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	360					multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(6)|prostate(1)|skin(2)	26						AATCCATCTTCAAATGGCCTC	0.368000													4	15					0.184627	0.185388	1	1	0
BCLAF1	9774	broad.mit.edu	37	6	136589379	136589379	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:136589379C>T	ENST00000531224.1	-	10	2570	c.2318G>A	c.(2317-2319)aGa>aAa	p.R773K	BCLAF1_ENST00000392348.2_Missense_Mutation_p.R771K|BCLAF1_ENST00000527759.1_Missense_Mutation_p.R771K|BCLAF1_ENST00000353331.4_Missense_Mutation_p.R771K|BCLAF1_ENST00000031135.9_5'UTR|BCLAF1_ENST00000527536.1_Missense_Mutation_p.R773K|BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000530767.1_Missense_Mutation_p.R600K	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	773					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding	p.R773I(1)		haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTCTTCTTCTCTTTCCTTCTT	0.383000													19	203					0	0	1	0	0
HSD17B13	345275	broad.mit.edu	37	4	88238288	88238288	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:88238288C>T	ENST00000328546.4	-	3	470	c.406G>A	c.(406-408)Gag>Aag	p.E136K	HSD17B13_ENST00000302219.6_Missense_Mutation_p.E100K	NM_178135.3	NP_835236.2	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	136						extracellular region	binding|oxidoreductase activity			endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	8		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		TTGGTAATCTCTTCATCCTTG	0.403000													39	57					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112103071	112103071	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:112103071G>T	ENST00000457016.1	+	4	786	c.406G>T	c.(406-408)Gaa>Taa	p.E136*	APC_ENST00000257430.4_Nonsense_Mutation_p.E136*|APC_ENST00000508376.2_Nonsense_Mutation_p.E136*			P25054	APC_HUMAN	adenomatous polyposis coli	136	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E136K(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ATATTTAGAAGAACTTGAGAA	0.338000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			35	16					2.75727e-19	3.0128e-19	1	1	0
COLGALT2	23127	broad.mit.edu	37	1	184006246	184006246	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:184006246C>A	ENST00000361927.4	-	1	617	c.246G>T	c.(244-246)aaG>aaT	p.K82N	COLGALT2_ENST00000546159.1_Missense_Mutation_p.K82N	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		CCATCCTGCTCTTGGGGTAGT	0.771000													4	14					1	1	1	1	0
SF3A1	10291	broad.mit.edu	37	22	30735229	30735229	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:30735229C>G	ENST00000215793.8	-	10	1541	c.1387G>C	c.(1387-1389)Gag>Cag	p.E463Q	SF3A1_ENST00000439242.1_Missense_Mutation_p.E398Q	NM_005877.4	NP_005868.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa						nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						AAGCTGCTCTCAATATCCAGA	0.493000													9	132					0	0	1	0	0
MYCN	4613	broad.mit.edu	37	2	16082542	16082542	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:16082542G>T	ENST00000281043.3	+	2	653	c.356G>T	c.(355-357)gGc>gTc	p.G119V		NM_005378.4	NP_005369.2	P04198	MYCN_HUMAN	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog	119					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			ATGTGGAGCGGCTTCTCCGCC	0.741000			A		neuroblastoma								3	13					0.115264	0.115898	1	1	0
SCAF11	9169	broad.mit.edu	37	12	46320089	46320089	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:46320089G>A	ENST00000465950.1	-	1	3659	c.2450C>T	c.(2449-2451)tCa>tTa	p.S817L	SCAF11_ENST00000549162.1_Missense_Mutation_p.S940L|SCAF11_ENST00000369367.3_Missense_Mutation_p.S1132L|SCAF11_ENST00000419565.2_Missense_Mutation_p.S1132L			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1132					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TGTATCAAATGAGAACTCCTG	0.443000													27	83					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	82072690	82072690	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:82072690G>A	ENST00000356860.3	-	1	424	c.86C>T	c.(85-87)tCg>tTg	p.S29L	CACNA2D1_ENST00000423588.1_Missense_Mutation_p.S29L|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.S29L	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	29						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CGTGACGGCCGAAGGGAACGG	0.682000													7	21					0	0	1	0	0
NOP14	8602	broad.mit.edu	37	4	2951772	2951772	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:2951772C>A	ENST00000416614.2	-	8	1236	c.1171G>T	c.(1171-1173)Gaa>Taa	p.E391*	NOP14_ENST00000314262.6_Nonsense_Mutation_p.E391*|NOP14-AS1_ENST00000515194.1_RNA|NOP14_ENST00000398071.4_Nonsense_Mutation_p.E391*|NOP14_ENST00000502735.1_Nonsense_Mutation_p.E391*|NOP14-AS1_ENST00000503709.1_RNA			P78316	NOP14_HUMAN	NOP14 nucleolar protein	391					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	30						TTCTCGTTTTCTTCCTCACTC	0.547000													11	288					3.45872e-05	3.58119e-05	1	1	0
UIMC1	51720	broad.mit.edu	37	5	176409576	176409576	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:176409576G>A	ENST00000377219.2	-	2	207	c.41C>T	c.(40-42)tCt>tTt	p.S14F	UIMC1_ENST00000506128.1_Missense_Mutation_p.S14F|UIMC1_ENST00000377227.4_Missense_Mutation_p.S14F|UIMC1_ENST00000511320.1_Missense_Mutation_p.S14F	NM_016290.4	NP_057374.3	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	14	Necessary for transcriptional repression.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	21	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGGTTCCGAGATTCGGAGAC	0.373000													11	67					0	0	1	0	0
GDPD3	79153	broad.mit.edu	37	16	30123483	30123483	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30123483C>A	ENST00000406256.3	-	6	920	c.543G>T	c.(541-543)aaG>aaT	p.K181N		NM_024307.2	NP_077283.2	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain containing 3	181	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)	11						TGACCGAGCTCTTCTCCGAGG	0.617000											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	71					1.04858e-14	1.13725e-14	1	1	0
ABCC3	8714	broad.mit.edu	37	17	48735563	48735563	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:48735563G>A	ENST00000285238.8	+	5	687	c.607G>A	c.(607-609)Gac>Aac	p.D203N	ABCC3_ENST00000427699.1_Missense_Mutation_p.D203N	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	203					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AAAGAATGTCGACCCTGTGAG	0.567000													15	74					0	0	1	0	0
ALDH9A1	223	broad.mit.edu	37	1	165648806	165648806	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:165648806G>T	ENST00000354775.4	-	6	1107	c.803C>A	c.(802-804)tCa>tAa	p.S268*	ALDH9A1_ENST00000538148.1_Nonsense_Mutation_p.S174*	NM_000696.3	NP_000687.3	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9 family, member A1	244					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	21	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	TCCTTTAGCTGACATCTCCAT	0.413000													25	154					3.65163e-15	3.96633e-15	1	1	0
CES3	23491	broad.mit.edu	37	16	66998585	66998585	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:66998585C>T	ENST00000303334.4	+	6	845	c.774C>T	c.(772-774)atC>atT	p.I258I	CES3_ENST00000394037.1_Silent_p.I258I	NM_024922.5	NP_079198.2	Q6UWW8	EST3_HUMAN	carboxylesterase 3	258						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	24		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GTGGGGTCATCACCACCCCAG	0.587000													32	23					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102552238	102552238	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:102552238G>A	ENST00000334701.7	-	4	1033	c.752C>T	c.(751-753)tCt>tTt	p.S251F	HSP90AA1_ENST00000216281.8_Missense_Mutation_p.S129F|HSP90AA1_ENST00000441629.2_Intron	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	129					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	GCCAATCATAGAGATATCTGC	0.443000													5	88					0	0	1	0	0
LIM2	3982	broad.mit.edu	37	19	51890572	51890572	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:51890572C>T	ENST00000221973.3	-	2	168	c.126G>A	c.(124-126)ctG>ctA	p.L42L	LIM2_ENST00000596399.1_Silent_p.L42L	NM_030657.3	NP_085915.2	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa	42					cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		AGTACCGCCACAGGCCCTGGT	0.667000													23	85					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116380132	116380132	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:116380132G>A	ENST00000397752.3	+	4	1721	c.1521G>A	c.(1519-1521)ggG>ggA	p.G507G	MET_ENST00000495962.1_3'UTR|MET_ENST00000436117.2_Silent_p.G507G|MET_ENST00000318493.6_Silent_p.G507G	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	507	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTATCACTGGGAAGAAGGTAA	0.438000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				7	135					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138619775	138619775	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:138619775G>A	ENST00000251691.4	+	22	3847	c.3681G>A	c.(3679-3681)caG>caA	p.Q1227Q		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	1227					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ATGTGTCTCAGAAGGCTGTTT	0.473000													28	25					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018968	62018968	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:62018968C>T	ENST00000578147.1	-	24	4750	c.4674G>A	c.(4672-4674)gaG>gaA	p.E1558E	SCN4A_ENST00000435607.1_Silent_p.E1558E			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1558					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TGCCCGGGTTCTCCAGGTTGG	0.602000													13	28					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139701194	139701194	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:139701194C>A	ENST00000303045.6	-	37	3274	c.2828G>T	c.(2827-2829)gGc>gTc	p.G943V	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Missense_Mutation_p.G943V	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	943	Collagen-like 8.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity	p.G943V(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCCTGGGGTGCCTCTGAGGCC	0.512000										HNSCC(7;0.00092)			12	66					1.15088e-07	1.20702e-07	1	1	0
CACNG1	786	broad.mit.edu	37	17	65052309	65052309	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:65052309C>T	ENST00000226021.3	+	4	662	c.591C>T	c.(589-591)ctC>ctT	p.L197L		NM_000727.3	NP_000718.1	Q06432	CCG1_HUMAN	calcium channel, voltage-dependent, gamma subunit 1	197					muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(1)|large_intestine(2)|lung(2)|prostate(1)|skin(2)	8	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	TCGGCGGTCTCGCCCTCCTGC	0.612000													11	63					0	0	1	0	0
GATA6	2627	broad.mit.edu	37	18	19762943	19762943	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:19762943C>G	ENST00000269216.3	+	6	1836	c.1559C>G	c.(1558-1560)tCt>tGt	p.S520C	GATA6_ENST00000581694.1_Missense_Mutation_p.S520C	NM_005257.4	NP_005248.2	Q92908	GATA6_HUMAN	GATA binding protein 6	520					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	18	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			ACTTCCACCTCTTCTAACTCA	0.393000													76	51					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202700976	202700976	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:202700976C>T	ENST00000367265.3	-	24	5165	c.4001G>A	c.(4000-4002)cGa>cAa	p.R1334Q	KDM5B_ENST00000367264.2_Missense_Mutation_p.R1370Q	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1334					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						GATACAACTTCGTCCAGTTGA	0.408000													7	75					0	0	1	0	0
NSUN6	221078	broad.mit.edu	37	10	18940106	18940106	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:18940106C>G	ENST00000377304.4	-	1	445	c.27G>C	c.(25-27)ttG>ttC	p.L9F	RP11-139J15.7_ENST00000606425.1_Intron	NM_182543.2	NP_872349.1	Q8TEA1	NSUN6_HUMAN	NOP2/Sun domain family, member 6	9							methyltransferase activity|RNA binding			endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15						CCTCAGGTCTCAAAGATATCT	0.333000													41	81					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50911948	50911948	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:50911948G>C	ENST00000313478.7	-	13	1769	c.1488C>G	c.(1486-1488)gtC>gtG	p.V496V	TRPM7_ENST00000560955.1_Silent_p.V496V	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	496					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TTACCTGTTTGACGTCTCGAA	0.234000													3	31					0	0	1	0	0
GSTM3	2947	broad.mit.edu	37	1	110280351	110280351	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:110280351A>T	ENST00000540225.1	-	7	705	c.395T>A	c.(394-396)tTg>tAg	p.L132*	GSTM3_ENST00000488824.1_5'UTR|GSTM3_ENST00000361066.2_Nonsense_Mutation_p.L132*|RP4-735C1.4_ENST00000431955.1_RNA|GSTM3_ENST00000256594.3_Nonsense_Mutation_p.L132*			P21266	GSTM3_HUMAN	glutathione S-transferase mu 3 (brain)	132	GST C-terminal.				establishment of blood-nerve barrier|glutathione metabolic process|response to estrogen stimulus	cytoplasm	glutathione transferase activity|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|skin(1)	9		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Colorectal(144;0.0339)|Lung(183;0.0426)|all cancers(265;0.113)|Epithelial(280;0.125)|COAD - Colon adenocarcinoma(174;0.134)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	TAGCTCTTCCAAGTACTGAGG	0.433000													45	93					0	0	1	0	0
TVP23C	201158	broad.mit.edu	37	17	15406428	15406428	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:15406428G>A	ENST00000225576.3	-	6	676	c.581C>T	c.(580-582)tCg>tTg	p.S194L	TVP23C-CDRT4_ENST00000522212.2_Intron|TVP23C_ENST00000519970.1_Missense_Mutation_p.S151L	NM_145301.2	NP_660344.2			trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)																		AAACTTCCTCGAGGGATggcc	0.562000													3	20					0	0	1	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39380188	39380188	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:39380188G>A	ENST00000402182.3	+	2	181	c.126G>A	c.(124-126)aaG>aaA	p.K42K	APOBEC3B_ENST00000407298.3_Silent_p.K42K|APOBEC3B_ENST00000333467.3_Silent_p.K42K			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	42					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding	p.K42K(1)		cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					TGAAAATAAAGAGGGGCCGCT	0.488000													4	71					0	0	1	0	0
ERMARD	55780	broad.mit.edu	37	6	170156863	170156863	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:170156863C>T	ENST00000588451.1	+	5	601	c.88C>T	c.(88-90)Ctt>Ttt	p.L30F	ERMARD_ENST00000366773.3_Missense_Mutation_p.L156F|ERMARD_ENST00000418781.3_Missense_Mutation_p.L156F|ERMARD_ENST00000392095.4_Missense_Mutation_p.L30F|ERMARD_ENST00000366772.2_Missense_Mutation_p.L156F					ER membrane-associated RNA degradation	156																	AAGAGATCTGCTTTCATCTGA	0.358000													30	87					0	0	1	0	0
TMEM130	222865	broad.mit.edu	37	7	98446226	98446226	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:98446226G>C	ENST00000450876.1	-	7	2162	c.847C>G	c.(847-849)Cag>Gag	p.Q283E	TMEM130_ENST00000345589.4_Missense_Mutation_p.Q265E|TMEM130_ENST00000339375.4_Missense_Mutation_p.Q367E|TMEM130_ENST00000546258.1_Missense_Mutation_p.Q348E|TMEM130_ENST00000416379.2_Missense_Mutation_p.Q367E			Q8N3G9	TM130_HUMAN	transmembrane protein 130	367						Golgi membrane|integral to membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	25	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCCTTTTGCTGAGTGGCATTC	0.552000													11	96					0	0	1	0	0
SSFA2	6744	broad.mit.edu	37	2	182786999	182786999	+	Missense_Mutation	SNP	G	G	A	rs61736565	byFrequency	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:182786999G>A	ENST00000431877.2	+	16	3714	c.3535G>A	c.(3535-3537)Gat>Aat	p.D1179N	SSFA2_ENST00000320370.7_Missense_Mutation_p.D1179N|SSFA2_ENST00000409001.1_Missense_Mutation_p.D1157N|SSFA2_ENST00000467172.2_3'UTR|SSFA2_ENST00000409136.1_Missense_Mutation_p.D688N|SSFA2_ENST00000428267.2_Missense_Mutation_p.D1004N	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	1179						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TGAGGAAGTTGATGCAGCTGA	0.493000													5	94					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68211501	68211501	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:68211501T>C	ENST00000262215.3	-	4	791	c.402A>G	c.(400-402)atA>atG	p.I134M		NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	134					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			AGCAGCCACATATTGTTTCAA	0.338000													8	15					0	0	1	0	0
CLEC5A	23601	broad.mit.edu	37	7	141645174	141645174	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:141645174C>T	ENST00000546910.1	-	3	302	c.106G>A	c.(106-108)Gat>Aat	p.D36N	CLEC5A_ENST00000551012.2_Missense_Mutation_p.D36N|CLEC5A_ENST00000438351.1_Missense_Mutation_p.D36N|CLEC5A_ENST00000439991.1_5'UTR|CLEC5A_ENST00000470595.1_Intron	NM_013252.2	NP_037384.1	Q9NY25	CLC5A_HUMAN	C-type lectin domain family 5, member A	36					anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity			endometrium(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	10	Melanoma(164;0.0171)					GTGAAACCATCGTTACTTTTG	0.438000													27	54					0	0	1	0	0
HNRNPK	3190	broad.mit.edu	37	9	86592650	86592650	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:86592650C>A	ENST00000376263.3	-	4	333	c.110G>T	c.(109-111)aGa>aTa	p.R37I	HNRNPK_ENST00000351839.3_Missense_Mutation_p.R37I|HNRNPK_ENST00000376264.2_Missense_Mutation_p.R37I|HNRNPK_ENST00000360384.5_Missense_Mutation_p.R37I|HNRNPK_ENST00000376281.4_Missense_Mutation_p.R37I	NM_031263.2	NP_112553.1	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	37	Interaction with ASFV p30.|Necessary for interaction with DDX1.				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|stomach(1)	19						ATCAGTGTTTCTAGATCTTTT	0.353000													4	64					1.23904e-05	1.29023e-05	1	1	0
PCDHA12	56137	broad.mit.edu	37	5	140256924	140256924	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:140256924C>T	ENST00000398631.2	+	1	1867	c.1867C>T	c.(1867-1869)Cac>Tac	p.H623Y	PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018903.2|NM_031864.2	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCCCGTTCCACGTGGGGCT	0.667000													4	55					0	0	1	0	0
SNX7	51375	broad.mit.edu	37	1	99161250	99161250	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:99161250G>C	ENST00000370189.5	+	6	988	c.624G>C	c.(622-624)caG>caC	p.Q208H	SNX7_ENST00000306121.3_Missense_Mutation_p.Q272H|SNX7_ENST00000529992.1_Missense_Mutation_p.Q217H			Q9UNH6	SNX7_HUMAN	sorting nexin 7	208					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	13		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		AAATATCTCAGAGAATTTATA	0.313000													6	93					0	0	1	0	0
FAM178A	55719	broad.mit.edu	37	10	102689105	102689105	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:102689105G>T	ENST00000238961.4	+	7	2616	c.2074G>T	c.(2074-2076)Gac>Tac	p.D692Y	FAM178A_ENST00000370269.3_Missense_Mutation_p.D692Y	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A																		ACTACAAGAAGACATAAGGCA	0.363000													16	10					1.5739e-10	1.67714e-10	1	1	0
OR2M7	391196	broad.mit.edu	37	1	248487813	248487813	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:248487813G>C	ENST00000317965.2	-	1	86	c.58C>G	c.(58-60)Cat>Gat	p.H20D		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGGGGCTATGATTGAAGATT	0.478000													13	278					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1906969	1906969	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:1906969C>G	ENST00000399161.2	-	14	2662	c.1915G>C	c.(1915-1917)Gag>Cag	p.E639Q	MYT1L_ENST00000428368.2_Missense_Mutation_p.E637Q	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	639					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GAATATTTCTCGAGCTCCTTG	0.498000													8	81					0	0	1	0	0
LRWD1	222229	broad.mit.edu	37	7	102106340	102106340	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:102106340G>A	ENST00000292616.5	+	2	309	c.157G>A	c.(157-159)Gac>Aac	p.D53N		NM_152892.1	NP_690852.1	Q9UFC0	LRWD1_HUMAN	leucine-rich repeats and WD repeat domain containing 1	53					chromatin modification|DNA-dependent DNA replication initiation|establishment of protein localization to chromatin|G1 phase of mitotic cell cycle	centromeric heterochromatin|nuclear origin of replication recognition complex|telomeric heterochromatin	chromatin binding|methyl-CpG binding|methylated histone residue binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|stomach(2)	20						GCAGGAGCTTGACCTGTCTAA	0.622000													24	42					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43044650	43044650	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:43044650C>T	ENST00000267890.6	-	14	2902	c.2794G>A	c.(2794-2796)Gat>Aat	p.D932N		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	932					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CTAACCATATCCTTCCGGGTT	0.428000													34	79					0	0	1	0	0
GDPD3	79153	broad.mit.edu	37	16	30123690	30123690	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30123690C>A	ENST00000406256.3	-	5	797	c.420G>T	c.(418-420)caG>caT	p.Q140H		NM_024307.2	NP_077283.2	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain containing 3	140	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)	11						TTGGAAACCTCTGGAACAGGT	0.622000											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	88					1.58986e-06	1.6579e-06	1	1	0
ALDH1L1	10840	broad.mit.edu	37	3	125828793	125828793	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:125828793G>A	ENST00000393434.2	-	20	2690	c.2341C>T	c.(2341-2343)Cgg>Tgg	p.R781W	ALDH1L1_ENST00000472186.1_Missense_Mutation_p.R781W|ALDH1L1_ENST00000452905.2_Missense_Mutation_p.R680W|ALDH1L1_ENST00000393431.2_3'UTR|ALDH1L1_ENST00000273450.3_Missense_Mutation_p.R791W	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	781	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TCACCTGGCCGAGGGACCTGA	0.597000													11	30					0	0	1	0	0
IGLV2-33	28811	broad.mit.edu	37	22	22930867	22930867	+	RNA	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:22930867C>T	ENST00000390302.2	+	0	120																											TGGGCCCAATCTGCCCTGACT	0.567000													40	156					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98241349	98241349	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:98241349G>A	ENST00000430669.2	-	8	1535	c.950C>T	c.(949-951)tCa>tTa	p.S317L	PTCH1_ENST00000437951.1_Missense_Mutation_p.S317L|PTCH1_ENST00000429896.2_Missense_Mutation_p.S232L|PTCH1_ENST00000375274.2_Missense_Mutation_p.S382L|PTCH1_ENST00000421141.1_Missense_Mutation_p.S232L|PTCH1_ENST00000331920.6_Missense_Mutation_p.S383L|PTCH1_ENST00000418258.1_Missense_Mutation_p.S232L			Q13635	PTC1_HUMAN	patched 1	383					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GTTGATGTGTGAGACATACTC	0.552000													26	34					0	0	1	0	0
TNPO3	23534	broad.mit.edu	37	7	128610354	128610354	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:128610354C>T	ENST00000393245.1	-	20	2921	c.2548G>A	c.(2548-2550)Gaa>Aaa	p.E850K	TNPO3_ENST00000471234.1_Missense_Mutation_p.E752K|TNPO3_ENST00000482320.1_Missense_Mutation_p.E750K|TNPO3_ENST00000471166.1_Missense_Mutation_p.E850K|TNPO3_ENST00000265388.5_Missense_Mutation_p.E816K	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	816					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						TTCCGTAATTCAAAGTCTTCT	0.458000													34	183					0	0	1	0	0
MAVS	57506	broad.mit.edu	37	20	3838392	3838392	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3838392G>A	ENST00000428216.2	+	3	356	c.228G>A	c.(226-228)ctG>ctA	p.L76L	MAVS_ENST00000416600.2_Intron|MAVS_ENST00000358134.6_Silent_p.L76L	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein	76	CARD.|Required for interaction with NLRX1.				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						TTGCGGCACTGAGGGGCTGTG	0.637000													13	112					0	0	1	0	0
BMX	660	broad.mit.edu	37	X	15540529	15540529	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:15540529C>T	ENST00000357607.2	+	7	759	c.571C>T	c.(571-573)Cta>Tta	p.L191L	BMX_ENST00000348343.6_Silent_p.L191L|BMX_ENST00000342014.6_Silent_p.L191L			P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	191					cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(14)|ovary(2)|urinary_tract(3)	30	Hepatocellular(33;0.183)					AAGTACCACTCTAGCCCAATA	0.428000													82	24					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114276668	114276668	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:114276668G>A	ENST00000357077.4	+	38	6947	c.6894G>A	c.(6892-6894)gaG>gaA	p.E2298E	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Silent_p.E2265E|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2265					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAGTCACTGAGGACTCAGAGA	0.488000													11	30					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145296564	145296564	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:145296564C>G	ENST00000342960.5	+	3	521	c.486C>G	c.(484-486)ctC>ctG	p.L162L	NBPF10_ENST00000369339.3_Intron|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	162										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TCCAAAAGCTCAGCCCAGGTA	0.572000													13	228					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8424198	8424198	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:8424198C>G	ENST00000360416.3	-	19	2409	c.2271G>C	c.(2269-2271)caG>caC	p.Q757H	MYH10_ENST00000379980.4_Missense_Mutation_p.Q742H|MYH10_ENST00000396239.1_Missense_Mutation_p.Q747H|MYH10_ENST00000269243.4_Missense_Mutation_p.Q726H	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	726	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						AGCAATACCTCTGTCTGAATT	0.398000													5	43					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65393495	65393495	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:65393495C>T	ENST00000355703.3	+	20	3888	c.3349C>T	c.(3349-3351)Ccg>Tcg	p.P1117S		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1117						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CGTGCTGAAGCCGCTGGAGTA	0.647000											OREG0021084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	13					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59949655	59949655	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:59949655C>T	ENST00000444766.3	-	20	2848	c.2773G>A	c.(2773-2775)Gaa>Aaa	p.E925K	INTS2_ENST00000251334.6_Missense_Mutation_p.E917K	NM_020748.2	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	925					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						TTTTTCAATTCTTCCCTGGTA	0.388000													14	28					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41906305	41906305	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:41906305G>C	ENST00000396930.3	-	3	734	c.191C>G	c.(190-192)tCa>tGa	p.S64*	KAT6A_ENST00000485568.1_Nonsense_Mutation_p.S64*|KAT6A_ENST00000406337.1_Nonsense_Mutation_p.S64*|KAT6A_ENST00000265713.2_Nonsense_Mutation_p.S64*	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	64	Required for activation of RUNX1-1.|Required for nuclear localization.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TCCTTTATTTGAGACTTTTAA	0.368000													28	206					0	0	1	0	0
NCLN	56926	broad.mit.edu	37	19	3186161	3186161	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:3186161G>C	ENST00000246117.4	+	1	564	c.133G>C	c.(133-135)Gag>Cag	p.E45Q	NCLN_ENST00000590671.1_Intron	NM_020170.3	NP_064555.2	Q969V3	NCLN_HUMAN	nicalin	45					proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding			kidney(1)|lung(3)|skin(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCGCGCACGAGTTCACCGT	0.721000													7	8					0	0	1	0	0
POLH	5429	broad.mit.edu	37	6	43555211	43555211	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43555211G>C	ENST00000372236.4	+	4	770	c.475G>C	c.(475-477)Gag>Cag	p.E159Q	POLH_ENST00000372226.1_Missense_Mutation_p.E159Q|POLH_ENST00000535400.1_Missense_Mutation_p.E97Q	NM_006502.2	NP_006493.1	Q9Y253	POLH_HUMAN	polymerase (DNA directed), eta	159	UmuC.				DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			AACGGCAGAAGAGACTGTTCA	0.473000								DNA polymerases (catalytic subunits)	Xeroderma Pigmentosum				5	61					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	157023793	157023793	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:157023793G>A	ENST00000348165.5	+	18	2613	c.2253G>A	c.(2251-2253)cgG>cgA	p.R751R		NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	751	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		TGAAAAAGCGGATCCGTGTGC	0.428000													6	114					0	0	1	0	0
COG4	25839	broad.mit.edu	37	16	70548332	70548332	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:70548332C>G	ENST00000323786.5	-	4	471	c.450G>C	c.(448-450)ttG>ttC	p.L150F	COG4_ENST00000564653.1_Missense_Mutation_p.L150F|COG4_ENST00000393612.4_Missense_Mutation_p.L146F	NM_001195139.1|NM_015386.2	NP_001182068.1|NP_056201.2	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	146	Interacts with STX5.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				CTTCACTCCTCAAAGCAGTCT	0.502000													3	35					0	0	1	0	0
NCSTN	23385	broad.mit.edu	37	1	160319451	160319451	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:160319451G>A	ENST00000368063.1	+	5	647	c.367G>A	c.(367-369)Gat>Aat	p.D123N	NCSTN_ENST00000459963.1_3'UTR|NCSTN_ENST00000294785.5_Missense_Mutation_p.D143N|NCSTN_ENST00000535857.1_Missense_Mutation_p.D143N|NCSTN_ENST00000392212.4_Missense_Mutation_p.D123N			Q92542	NICA_HUMAN	nicastrin	143					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(2)	34	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGCCCAAATGATGGGTTTGG	0.507000													18	25					0	0	1	0	0
INO80	54617	broad.mit.edu	37	15	41377728	41377728	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:41377728C>T	ENST00000361937.3	-	7	1136	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K	INO80_ENST00000401393.3_Missense_Mutation_p.E238K			Q9ULG1	INO80_HUMAN	INO80 complex subunit	238	Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.|Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GGGGATTCTTCAGAGGAAAGT	0.438000													5	95					0	0	1	0	0
POGK	57645	broad.mit.edu	37	1	166810266	166810266	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:166810266G>A	ENST00000367875.1	+	2	433	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K	POGK_ENST00000536514.1_5'UTR|POGK_ENST00000367876.4_Missense_Mutation_p.E25K|POGK_ENST00000537173.1_5'UTR			Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	25					multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	22						TCAGAGCCGGGAACTAGAGGA	0.517000													45	88					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72433764	72433764	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:72433764C>G	ENST00000373517.3	-	1	920	c.565G>C	c.(565-567)Gag>Cag	p.E189Q	NAP1L2_ENST00000536638.1_Missense_Mutation_p.E47Q	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	189	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					ATACCCTCCTCATTACCATAC	0.418000													5	81					0	0	1	0	0
IGHV3-23	28442	broad.mit.edu	37	14	106725385	106725385	+	RNA	SNP	A	A	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:106725385A>T	ENST00000390609.2	-	0	245																											AGCCTGGCGGACCCAGCTCAT	0.597000													75	265					0	0	1	0	0
PCM1	5108	broad.mit.edu	37	8	17813070	17813070	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:17813070C>T	ENST00000325083.8	+	10	1819	c.1380C>T	c.(1378-1380)agC>agT	p.S460S	PCM1_ENST00000518537.1_Silent_p.S499S|PCM1_ENST00000519253.1_Silent_p.S460S|PCM1_ENST00000524226.1_Silent_p.S460S	NM_006197.3	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	460					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		AATCCAATAGCCTCACATCAT	0.458000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								7	23					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69045056	69045056	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:69045056C>T	ENST00000295381.3	+	8	1349	c.930C>T	c.(928-930)gaC>gaT	p.D310D	ARHGAP25_ENST00000497079.1_Silent_p.D304D|ARHGAP25_ENST00000409202.3_Silent_p.D311D|ARHGAP25_ENST00000409220.1_Silent_p.D304D|ARHGAP25_ENST00000409030.3_Silent_p.D303D|ARHGAP25_ENST00000479844.1_Silent_p.D4D|ARHGAP25_ENST00000467265.1_Silent_p.D271D	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	310	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						TGAGTGTGGACAACCTGGCTA	0.488000													27	37					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19619665	19619665	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:19619665C>T	ENST00000341998.2	-	3	1056	c.995G>A	c.(994-996)gGa>gAa	p.G332E	SLC24A2_ENST00000286344.3_Missense_Mutation_p.G332E	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	332					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GGCAGAGCTTCCACCTCGCTG	0.488000													8	103					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139908491	139908491	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:139908491C>T	ENST00000265662.5	-	28	4388		c.e28-1		ABCA2_ENST00000341511.6_Splice_Site|ABCA2_ENST00000371605.3_Splice_Site			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2						cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCCTCCACCTCTGTGCAGAGA	0.682000													7	17					0	0	1	0	0
MARCH7	64844	broad.mit.edu	37	2	160609027	160609027	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:160609027G>C	ENST00000259050.4	+	6	1850	c.1728G>C	c.(1726-1728)ttG>ttC	p.L576F	MARCH7_ENST00000409591.1_Missense_Mutation_p.L538F|MARCH7_ENST00000409175.1_Missense_Mutation_p.L576F|MARCH7_ENST00000539065.1_Missense_Mutation_p.L520F	NM_001282805.1|NM_001282807.1|NM_022826.2	NP_001269734.1|NP_001269736.1|NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase								ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						CAGGAAGTTTGCAGTATGTCC	0.383000													48	121					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101163293	101163293	+	Nonstop_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:101163293C>G	ENST00000522650.1	-	13	2540	c.2196G>C	c.(2194-2196)taG>taC	p.*732Y	ASCC3_ENST00000369162.2_Intron	NM_001284271.1	NP_001271200.1	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	0	Helicase C-terminal 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TAAGCACTCTCTAAAAGCAGA	0.299000													7	31					0	0	1	0	0
CYP2A6	1548	broad.mit.edu	37	19	41355876	41355876	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:41355876G>A	ENST00000301141.5	-	2	210	c.190C>T	c.(190-192)Cgc>Tgc	p.R64C	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	64					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	GGGCCATAGCGCTCACTGATC	0.617000													4	39					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19745863	19745863	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:19745863C>T	ENST00000203556.4	-	16	1857	c.1720G>A	c.(1720-1722)Gag>Aag	p.E574K	GMIP_ENST00000445806.2_Missense_Mutation_p.E545K|GMIP_ENST00000586269.1_5'UTR|GMIP_ENST00000587238.1_Missense_Mutation_p.E548K	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	574	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TGTTCTATCTCAGCCGTGCAC	0.597000													17	92					0	0	1	0	0
RP11-337C18.8	0	broad.mit.edu	37	1	146650694	146650694	+	RNA	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:146650694G>A	ENST00000607149.1	+	0	350				RP11-337C18.8_ENST00000606757.1_RNA|RP11-337C18.10_ENST00000606856.1_RNA																							CTAAAGGAGAGAAGTTTGTCA	0.463000													17	112					0	0	1	0	0
PSMA1	5682	broad.mit.edu	37	11	14529258	14529258	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:14529258C>T	ENST00000530457.1	-	9	1134	c.604G>A	c.(604-606)Gat>Aat	p.D202N	PSMA1_ENST00000419365.2_3'UTR|PSMA1_ENST00000396393.1_Missense_Mutation_p.D227N|PSMA1_ENST00000555531.1_3'UTR|PSMA1_ENST00000418988.2_Missense_Mutation_p.D233N|PSMA1_ENST00000524606.1_5'UTR|PSMA1_ENST00000396394.2_Missense_Mutation_p.D227N			P25786	PSA1_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 1	227					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	3						GACACATCATCATCATCATAG	0.353000													26	21					0	0	1	0	0
EIF4E	1977	broad.mit.edu	37	4	99802262	99802262	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:99802262G>C	ENST00000450253.2	-	7	2095	c.571C>G	c.(571-573)Cca>Gca	p.P191A	EIF4E_ENST00000505992.1_Missense_Mutation_p.P222A|EIF4E_ENST00000280892.6_Missense_Mutation_p.P211A|EIF4E_ENST00000504432.1_Missense_Mutation_p.P219A	NM_001968.3	NP_001959.1	P06730	IF4E_HUMAN	eukaryotic translation initiation factor 4E	191					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|interspecies interaction between organisms|mRNA export from nucleus|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of mitotic cell cycle|regulation of translation	cytoplasmic mRNA processing body|cytosol|eukaryotic translation initiation factor 4F complex|mRNA cap binding complex|RNA-induced silencing complex	protein binding|RNA cap binding|translation initiation factor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)	13				OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)|LUSC - Lung squamous cell carcinoma(721;0.00227)		ACTATCTTTGGAGGAAGTCCT	0.363000													9	37					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2047456	2047456	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:2047456G>T	ENST00000382203.1	+	5	1227	c.1018G>T	c.(1018-1020)Gtg>Ttg	p.V340L	SMARCA2_ENST00000357248.2_Missense_Mutation_p.V340L|SMARCA2_ENST00000382194.1_Missense_Mutation_p.V340L|SMARCA2_ENST00000349721.2_Missense_Mutation_p.V340L			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	340					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CCTGGACCCCGTGGAAATTCT	0.692000													4	8					0.014758	0.0149213	1	1	0
SRRM2	23524	broad.mit.edu	37	16	2817596	2817596	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:2817596G>A	ENST00000301740.8	+	11	7616	c.7067G>A	c.(7066-7068)aGa>aAa	p.R2356K	SRRM2_ENST00000574593.1_3'UTR	NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	2356	Ala-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						GCCGGCTCCAGAACCGCCGCA	0.627000													18	155					0	0	1	0	0
CPLX1	10815	broad.mit.edu	37	4	780459	780459	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:780459C>T	ENST00000304062.6	-	4	466	c.235G>A	c.(235-237)Gag>Aag	p.E79K	CPLX1_ENST00000505203.1_Missense_Mutation_p.E58K	NM_006651.3	NP_006642.1	O14810	CPLX1_HUMAN	complexin 1	79					glutamate secretion	cytosol				kidney(1)|lung(2)	3				Colorectal(103;0.187)		GCCTCGGCCTCGCGCTCCTCC	0.756000													13	13					0	0	1	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24528378	24528378	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:24528378C>T	ENST00000357578.3	+	8	1472	c.1327C>T	c.(1327-1329)Ctg>Ttg	p.L443L	ALDH5A1_ENST00000348925.2_Silent_p.L456L|ALDH5A1_ENST00000491546.1_Silent_p.L415L|ALDH5A1_ENST00000546278.1_Silent_p.L355L	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1	443					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	TTTCGGGCCTCTGGCACCAGT	0.488000													22	29					0	0	1	0	0
USP4	7375	broad.mit.edu	37	3	49331930	49331930	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:49331930G>A	ENST00000351842.4	-	13	1660	c.1652C>T	c.(1651-1653)tCa>tTa	p.S551L	USP4_ENST00000265560.4_Missense_Mutation_p.S598L	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	598					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		ATATAGCGCTGATGCGGAGGA	0.527000													8	80					0	0	1	0	0
PABPN1	8106	broad.mit.edu	37	14	23792641	23792641	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:23792641C>T	ENST00000397276.2	+	4	603	c.590C>T	c.(589-591)tCa>tTa	p.S197L	PABPN1_ENST00000216727.4_Missense_Mutation_p.S197L|PABPN1_ENST00000557702.1_Missense_Mutation_p.S69L|PABPN1_ENST00000556821.1_Missense_Mutation_p.S69L|BCL2L2-PABPN1_ENST00000557008.1_Missense_Mutation_p.S224L|BCL2L2-PABPN1_ENST00000553781.1_Missense_Mutation_p.S224L					poly(A) binding protein, nuclear 1											large_intestine(1)|lung(1)|ovary(2)	4	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GGCTGTGGTTCAGTCAACCGT	0.428000													9	78					0	0	1	0	0
ZNF777	27153	broad.mit.edu	37	7	149129350	149129350	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:149129350C>T	ENST00000247930.4	-	6	2336	c.2013G>A	c.(2011-2013)aaG>aaA	p.K671K		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	671					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGCGGAAGCTCTTCTTGCACT	0.622000													30	133					0	0	1	0	0
SLC27A3	11000	broad.mit.edu	37	1	153748380	153748380	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:153748380G>A	ENST00000271857.2	+	1	1551	c.791G>A	c.(790-792)gGa>gAa	p.G264E	SLC27A3_ENST00000368661.3_Missense_Mutation_p.G183E|SLC27A3_ENST00000484014.1_Intron			Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3	183					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCAGCGCCGGGAGCCGGAGAT	0.741000													5	15					0	0	1	0	0
IPP	3652	broad.mit.edu	37	1	46182672	46182672	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:46182672C>T	ENST00000396478.3	-	7	1306	c.1204G>A	c.(1204-1206)Gag>Aag	p.E402K		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	402						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					TTCCCTATCTCAGCTCCAACC	0.373000													11	98					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90420473	90420473	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:90420473G>C	ENST00000369393.3	-	50	7807	c.7692C>G	c.(7690-7692)ctC>ctG	p.L2564L	MDN1_ENST00000428876.1_Silent_p.L2564L			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	2564					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AAAAATTCCTGAGAGATGCAG	0.398000													15	33					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73649905	73649905	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:73649905G>A	ENST00000377687.4	+	4	1791	c.1255G>A	c.(1255-1257)Gag>Aag	p.E419K	KLF5_ENST00000539231.1_Missense_Mutation_p.E328K	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	419					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding	p.E419Q(2)		breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		GCGATCGGATGAGCTGACCCG	0.592000													7	54					0	0	1	0	0
NFKBIZ	64332	broad.mit.edu	37	3	101572646	101572646	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:101572646G>C	ENST00000326172.5	+	5	1391	c.1276G>C	c.(1276-1278)Gaa>Caa	p.E426Q	NFKBIZ_ENST00000394054.2_Missense_Mutation_p.E326Q|NFKBIZ_ENST00000326151.5_Missense_Mutation_p.E304Q	NM_031419.3	NP_113607.1	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	426	Interaction with NFKB1/p50 (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24						GGAGCAGGAAGAAAGCAAATT	0.403000													34	46					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62194088	62194088	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:62194088G>A	ENST00000467148.1	-	8	6156	c.6087C>T	c.(6085-6087)ctC>ctT	p.L2029L	HELZ2_ENST00000427522.2_Silent_p.L1460L	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		GGCCAGGGCCGAGGCTGCTGG	0.697000													5	6					0	0	1	0	0
GP5	2814	broad.mit.edu	37	3	194117344	194117344	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:194117344C>T	ENST00000401815.1	-	1	1739	c.1668G>A	c.(1666-1668)gaG>gaA	p.E556E	GP5_ENST00000323007.3_Silent_p.E556E			P40197	GPV_HUMAN	glycoprotein V (platelet)	556					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				breast(3)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(14)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	35	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		CAAGGGCTCTCTCTCTGATTA	0.443000													38	186					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89800436	89800436	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:89800436C>T	ENST00000289816.5	+	9	1551	c.1239C>T	c.(1237-1239)ctC>ctT	p.L413L	ZNF276_ENST00000446326.2_Silent_p.L274L|ZNF276_ENST00000443381.2_Silent_p.L488L|ZNF276_ENST00000568064.1_Silent_p.L396L	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	488				P -> Q (in Ref. 3; AAQ15128/AAQ15129).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		ACGTGAAGCTCATCCACACAG	0.637000													10	19					0	0	1	0	0
CDCP2	200008	broad.mit.edu	37	1	54606823	54606823	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:54606823G>C	ENST00000371330.1	-	3	1558	c.711C>G	c.(709-711)ttC>ttG	p.F237L		NM_201546.2	NP_963840.2	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2	237	CUB 2.					extracellular region				kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|stomach(1)	24						AGTCGGACTTGAAGACCACCT	0.647000													8	48					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25473926	25473926	+	RNA	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:25473926G>C	ENST00000453082.2	+	0	1238					NR_003343.1																						TGTCCCTCCAGATGGTAAGCC	0.547000													8	17					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43382132	43382132	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:43382132G>A	ENST00000244296.2	-	2	500	c.363C>T	c.(361-363)acC>acT	p.T121T	PSG1_ENST00000436291.2_Silent_p.T121T|PSG1_ENST00000595356.1_Silent_p.T121T|PSG1_ENST00000312439.6_Silent_p.T121T|PSG1_ENST00000601073.1_5'UTR|PSG1_ENST00000403380.3_Silent_p.T121T|PSG1_ENST00000595124.1_Silent_p.T121T	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				TGATGTGTAAGGTGTAGGATC	0.478000													31	280					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53242451	53242451	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:53242451G>A	ENST00000304620.4	-	1	327	c.264C>T	c.(262-264)atC>atT	p.I88I		NM_173352.2	NP_775487.2	Q8N1N4	K2C78_HUMAN	keratin 78	88	Head.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						GATTCTGGTTGATGGTCACTT	0.622000													11	29					0	0	1	0	0
CLASP1	23332	broad.mit.edu	37	2	122122825	122122825	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:122122825G>A	ENST00000263710.4	-	36	4311	c.3922C>T	c.(3922-3924)Ctg>Ttg	p.L1308L	CLASP1_ENST00000541859.1_Silent_p.L1025L|CLASP1_ENST00000455322.2_Silent_p.L1264L|CLASP1_ENST00000545861.1_Silent_p.L1015L|CLASP1_ENST00000397587.3_Silent_p.L1248L|CLASP1_ENST00000541377.1_Silent_p.L1247L|CLASP1_ENST00000409078.3_Silent_p.L1241L	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	1308	Interaction with CLIP2 (By similarity).|Interaction with PHLDB2 and RSN.|Localization to kinetochores.				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					AGCTCTTTCAGAAGGTCAGCC	0.572000													3	21					0	0	1	0	0
VGF	7425	broad.mit.edu	37	7	100806828	100806828	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:100806828C>T	ENST00000249330.2	-	2	1536	c.1297G>A	c.(1297-1299)Gag>Aag	p.E433K	VGF_ENST00000445482.2_Missense_Mutation_p.E433K	NM_003378.3	NP_003369.2	O15240	VGF_HUMAN	VGF nerve growth factor inducible	433	Asp/Glu-rich (acidic).				response to cAMP	extracellular space|transport vesicle	growth factor activity			cervix(1)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	9	Lung NSC(181;0.168)|all_lung(186;0.215)					tctgtcccctcggcctccttc	0.687000													3	15					0	0	1	0	0
STX17	55014	broad.mit.edu	37	9	102729973	102729973	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:102729973C>T	ENST00000259400.6	+	7	757	c.621C>T	c.(619-621)gtC>gtT	p.V207V	STX17_ENST00000525640.1_Silent_p.V207V|STX17_ENST00000525847.1_3'UTR|STX17_ENST00000534052.1_Silent_p.V207V	NM_017919.2	NP_060389.2	P56962	STX17_HUMAN	syntaxin 17	207	t-SNARE coiled-coil homology.				intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum|integral to membrane|nucleolus	SNAP receptor activity			endometrium(2)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				CAGACCATGTCAACAGTGCTG	0.493000													35	46					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57188486	57188486	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:57188486G>A	ENST00000331162.4	-	5	906	c.636C>T	c.(634-636)tcC>tcT	p.S212S		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			TGCATTTGTAGGACTTCTCCC	0.333000													11	19					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100210735	100210735	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:100210735G>A	ENST00000409236.2	-	13	1500	c.1388C>T	c.(1387-1389)tCt>tTt	p.S463F	AFF3_ENST00000409579.1_Missense_Mutation_p.S488F|AFF3_ENST00000317233.4_Missense_Mutation_p.S463F|AFF3_ENST00000356421.2_Missense_Mutation_p.S488F			P51826	AFF3_HUMAN	AF4/FMR2 family, member 3						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						CCACTTGTTAGAGGATGCCGG	0.443000													32	214					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139873474	139873474	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:139873474C>T	ENST00000224167.2	+	2	219	c.144C>T	c.(142-144)ctC>ctT	p.L48L	PTGDS_ENST00000460340.1_3'UTR|PTGDS_ENST00000371625.3_Silent_p.L48L			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	48					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCGCGGGCCTCGCCTCCAACT	0.711000													4	31					0	0	1	0	0
DEF8	54849	broad.mit.edu	37	16	90016035	90016035	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:90016035G>A	ENST00000268676.7	+	2	251	c.162G>A	c.(160-162)acG>acA	p.T54T	DEF8_ENST00000563795.1_Intron|DEF8_ENST00000418391.2_Intron|DEF8_ENST00000570182.1_Intron|DEF8_ENST00000563594.1_Intron|DEF8_ENST00000569453.1_Intron|DEF8_ENST00000567874.1_Intron	NM_207514.2	NP_997397.1	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 homolog (mouse)	54					intracellular signal transduction		zinc ion binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		CGGGCAGGACGCGGGAGGCCA	0.677000													4	19					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8222159	8222159	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:8222159C>T	ENST00000361926.3	+	12	2074	c.1964C>T	c.(1963-1965)tCg>tTg	p.S655L	ARHGEF15_ENST00000421050.1_Missense_Mutation_p.S655L|ARHGEF15_ENST00000582060.1_3'UTR	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	655					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						CTCTTTGCCTCGCGCCCCCGC	0.642000													33	293					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120263009	120263009	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:120263009C>A	ENST00000392521.2	-	8	972	c.917G>T	c.(916-918)gGa>gTa	p.G306V	CIT_ENST00000261833.7_Missense_Mutation_p.G306V	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	306	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GGCAGAGGTTCCCTCTGCGAA	0.458000													4	73					0.00024832	0.000254589	1	1	0
COMMD9	29099	broad.mit.edu	37	11	36302292	36302292	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:36302292G>A	ENST00000263401.5	-	2	163	c.147C>T	c.(145-147)agC>agT	p.S49S	COMMD9_ENST00000532705.1_Silent_p.S49S|COMMD9_ENST00000452374.2_Intron	NM_014186.3	NP_054905.2	Q9P000	COMD9_HUMAN	COMM domain containing 9	49										kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	5	all_lung(20;0.211)	all_hematologic(20;0.107)				TCACAGACAAGCTGGAACATG	0.468000													6	68					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20903661	20903661	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:20903661C>T	ENST00000381552.1	+	14	2219	c.1851C>T	c.(1849-1851)ctC>ctT	p.L617L	SLCO1C1_ENST00000540354.1_Silent_p.L568L|SLCO1C1_ENST00000266509.2_Silent_p.L617L|SLCO1C1_ENST00000545102.1_Silent_p.L499L|SLCO1C1_ENST00000545604.1_Silent_p.L617L			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	617					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					CTTCATGCCTCAAATGGGGAT	0.363000													17	70					0	0	1	0	0
SP100	6672	broad.mit.edu	37	2	231327168	231327168	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:231327168C>G	ENST00000264052.5	+	10	1347	c.992C>G	c.(991-993)tCt>tGt	p.S331C	SP100_ENST00000409897.1_Missense_Mutation_p.S296C|SP100_ENST00000409112.1_Missense_Mutation_p.S331C|SP100_ENST00000409341.1_Missense_Mutation_p.S331C|SP100_ENST00000427101.2_Missense_Mutation_p.S306C|SP100_ENST00000409824.1_Missense_Mutation_p.S306C|SP100_ENST00000340126.4_Missense_Mutation_p.S331C|SP100_ENST00000341950.4_Missense_Mutation_p.S331C	NM_003113.3	NP_003104.2	P23497	SP100_HUMAN	SP100 nuclear antigen	331					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGTGAGGACTCTGAAGGATCC	0.502000													21	23					0	0	1	0	0
DENND4C	55667	broad.mit.edu	37	9	19324380	19324380	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:19324380C>T	ENST00000380432.2	+	9	1153	c.1120C>T	c.(1120-1122)Cgt>Tgt	p.R374C	DENND4C_ENST00000602925.1_Missense_Mutation_p.R610C|DENND4C_ENST00000434457.2_Missense_Mutation_p.R610C			Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	374	dDENN.					integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						AAGTCGAGATCGTGCCTATGC	0.279000													29	71					0	0	1	0	0
CDC45	8318	broad.mit.edu	37	22	19470241	19470241	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:19470241G>C	ENST00000407835.1	+	5	489	c.233G>C	c.(232-234)gGa>gCa	p.G78A	CDC45_ENST00000263201.1_Missense_Mutation_p.G78A|CDC45_ENST00000437685.2_Missense_Mutation_p.G78A|CDC45_ENST00000483431.1_3'UTR|CDC45_ENST00000404724.3_Intron			O75419	CDC45_HUMAN	cell division cycle 45	78					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	19						ATAAACTGTGGAGCTAATGTA	0.373000													8	132					0	0	1	0	0
ATP5J	522	broad.mit.edu	37	21	27101968	27101968	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:27101968C>A	ENST00000400093.3	-	2	829	c.138G>T	c.(136-138)aaG>aaT	p.K46N	ATP5J_ENST00000400090.3_Missense_Mutation_p.K46N|ATP5J_ENST00000400094.1_Missense_Mutation_p.K46N|ATP5J_ENST00000284971.3_Missense_Mutation_p.K46N|ATP5J_ENST00000400087.3_Missense_Mutation_p.K46N|ATP5J_ENST00000457143.2_Missense_Mutation_p.K54N|ATP5J_ENST00000400099.1_Missense_Mutation_p.K46N	NM_001003701.1|NM_001003703.1|NM_001685.4	NP_001003701.1|NP_001003703.1|NP_001676.2	P18859	ATP5J_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6	46					ATP catabolic process|respiratory electron transport chain		hydrogen ion transmembrane transporter activity			cervix(1)|endometrium(1)|lung(1)|pancreas(1)	4						ATTCTCTAATCTTGTCCACAA	0.348000													4	25					0.00024832	0.000254589	1	1	0
TRIM25	7706	broad.mit.edu	37	17	54991173	54991173	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:54991173C>T	ENST00000316881.4	-	1	226	c.177G>A	c.(175-177)gcG>gcA	p.A59A	TRIM25_ENST00000537230.1_Silent_p.A59A	NM_005082.4	NP_005073.2	Q14258	TRI25_HUMAN	tripartite motif containing 25	59					innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Breast(9;6.15e-08)					GCTGCGGTCGCGCCTGGTAGA	0.692000													3	7					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42144735	42144735	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:42144735G>C	ENST00000444063.1	+	4	642	c.510G>C	c.(508-510)gaG>gaC	p.E170D	L3MBTL1_ENST00000427442.2_Missense_Mutation_p.E238D|L3MBTL1_ENST00000457824.1_3'UTR|L3MBTL1_ENST00000418998.1_Missense_Mutation_p.E238D|L3MBTL1_ENST00000373134.1_Missense_Mutation_p.E170D|L3MBTL1_ENST00000373135.3_Missense_Mutation_p.E170D			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	170					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						TTCTACAGGAGAAGCAAGAAG	0.577000													6	33					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126542614	126542614	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:126542614G>A	ENST00000339582.2	-	6	1946	c.1138C>T	c.(1138-1140)Cat>Tat	p.H380Y	GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000405249.1_Missense_Mutation_p.H380Y|GRM8_ENST00000444921.2_Missense_Mutation_p.H380Y|GRM8_ENST00000358373.3_Missense_Mutation_p.H380Y			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	380					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TTCTTTATATGACTGTTCCTT	0.353000										HNSCC(24;0.065)			6	64					0	0	1	0	0
DPY30	84661	broad.mit.edu	37	2	32264363	32264363	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:32264363G>C	ENST00000342166.5	-	3	184	c.69C>G	c.(67-69)ctC>ctG	p.L23L	DPY30_ENST00000295066.3_Silent_p.L23L			Q9C005	DPY30_HUMAN	dpy-30 homolog (C. elegans)	23					endosome transport|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Set1C/COMPASS complex|trans-Golgi network	protein homodimerization activity			large_intestine(2)	2	Acute lymphoblastic leukemia(172;0.155)					CGTTGTCTGTGAGACCGTACT	0.493000													16	112					0	0	1	0	0
NCSTN	23385	broad.mit.edu	37	1	160318836	160318836	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:160318836G>A	ENST00000368063.1	+	4	458	c.178G>A	c.(178-180)Gag>Aag	p.E60K	NCSTN_ENST00000294785.5_Missense_Mutation_p.E80K|NCSTN_ENST00000535857.1_Missense_Mutation_p.E80K|NCSTN_ENST00000392212.4_Missense_Mutation_p.E60K			Q92542	NICA_HUMAN	nicastrin	80					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(2)	34	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGAGAAAGAGGAGGACCTACA	0.463000													22	68					0	0	1	0	0
SAMD4A	23034	broad.mit.edu	37	14	55169071	55169071	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:55169071G>A	ENST00000251091.5	+	2	793	c.488G>A	c.(487-489)cGa>cAa	p.R163Q	SAMD4A_ENST00000357634.3_Missense_Mutation_p.R162Q|SAMD4A_ENST00000555112.1_3'UTR|SAMD4A_ENST00000554335.1_Missense_Mutation_p.R163Q|SAMD4A_ENST00000392067.3_Missense_Mutation_p.R163Q	NM_001161576.2	NP_001155048.2	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4A	163					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)	29						GGCCAGAACCGAGGCCGCTCA	0.512000													27	61					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241951319	241951319	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:241951319G>A	ENST00000366552.2	+	23	3051	c.2844G>A	c.(2842-2844)ctG>ctA	p.L948L	WDR64_ENST00000437684.2_Silent_p.L781L	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	948										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			AATATCCTCTGATATTTGACC	0.358000													27	58					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180326337	180326337	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:180326337G>C	ENST00000231229.4	+	1	261	c.27G>C	c.(25-27)ctG>ctC	p.L9L	BTNL8_ENST00000340184.4_Silent_p.L9L|BTNL8_ENST00000508408.1_Silent_p.L9L|BTNL8_ENST00000511704.1_Silent_p.L9L|BTNL8_ENST00000400707.3_5'UTR	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	9						integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTTGGTTCTGAGTCTCCTCA	0.453000													40	180					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57188487	57188487	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:57188487G>A	ENST00000331162.4	-	5	905	c.635C>T	c.(634-636)tCc>tTc	p.S212F		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			GCATTTGTAGGACTTCTCCCT	0.333000													11	18					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87165842	87165842	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:87165842C>T	ENST00000265724.3	-	21	2830	c.2413G>A	c.(2413-2415)Gat>Aat	p.D805N	ABCB1_ENST00000543898.1_Missense_Mutation_p.D741N	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	805	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity	p.D805N(1)		NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTAGGGTCATCAAACCAACTC	0.458000													6	56					0	0	1	0	0
CD2AP	23607	broad.mit.edu	37	6	47512409	47512409	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:47512409G>A	ENST00000359314.5	+	4	843	c.387G>A	c.(385-387)ctG>ctA	p.L129L		NM_012120.2	NP_036252.1	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	129	Interaction with ANLN and localization to the midbody.|SH3 2.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	20			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			AACTGGAGCTGAAAGTGGGAG	0.303000													5	103					0	0	1	0	0
CRYGN	155051	broad.mit.edu	37	7	151135092	151135092	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:151135092G>T	ENST00000337323.2	-	2	386	c.260C>A	c.(259-261)cCt>cAt	p.P87H	CRYGN_ENST00000491928.1_Missense_Mutation_p.P87H|CRYGN_ENST00000476631.1_5'UTR|RP4-555L14.4_ENST00000465549.1_RNA	NM_144727.1	NP_653328.1	Q8WXF5	CRGN_HUMAN	crystallin, gamma N	87	Beta/gamma crystallin 'Greek key' 2.									central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(1)|lung(4)	8			OV - Ovarian serous cystadenocarcinoma(82;0.00358)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATTCCTACAGGCCGACAGGA	0.642000													16	52					3.45872e-05	3.58119e-05	1	1	0
ERBB4	2066	broad.mit.edu	37	2	212288890	212288890	+	Silent	SNP	G	G	A	rs114556844	by1000genomes	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:212288890G>A	ENST00000342788.4	-	23	3166	c.2856C>T	c.(2854-2856)gtC>gtT	p.V952V	ERBB4_ENST00000402597.1_Silent_p.V942V|ERBB4_ENST00000436443.1_Silent_p.V952V	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	952	Protein kinase.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ATTTGACCATGACCATGTAAA	0.378000										TSP Lung(8;0.080)			5	108					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40852632	40852632	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:40852632C>T	ENST00000254691.5	+	3	1397	c.1198C>T	c.(1198-1200)Cag>Tag	p.Q400*	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	400					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						AAACATGTATCAGTGCCAGTT	0.453000													23	47					0	0	1	0	0
ZNF280A	129025	broad.mit.edu	37	22	22869392	22869392	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:22869392G>A	ENST00000302097.3	-	2	815	c.563C>T	c.(562-564)cCa>cTa	p.P188L		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AGGTACCCCTGGGATTCCATC	0.448000													13	141					0	0	1	0	0
RDM1	201299	broad.mit.edu	37	17	34251717	34251717	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:34251717C>T	ENST00000394529.3	-	3	876	c.390G>A	c.(388-390)ccG>ccA	p.P130P	RDM1_ENST00000425909.3_Intron|RDM1_ENST00000293273.6_Silent_p.P153P|RDM1_ENST00000419453.2_Silent_p.P130P|RDM1_ENST00000394527.1_Intron|RDM1_ENST00000431884.2_Silent_p.P153P|RDM1_ENST00000591402.1_Intron|RDM1_ENST00000430160.2_Silent_p.P130P|RDM1_ENST00000394528.3_Silent_p.P153P	NM_001163130.1	NP_001156602.1	Q8NG50	RDM1_HUMAN	RAD52 motif 1	153	Necessary for nuclear and nucleolar localization.				DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			breast(1)|kidney(3)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)	9		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GGCTTTGCTTCGGAAGTGGCA	0.468000								Other identified genes with known or suspected DNA repair function					32	82					0	0	1	0	0
MYLK2	85366	broad.mit.edu	37	20	30409372	30409372	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:30409372G>A	ENST00000375994.2	+	3	877	c.604G>A	c.(604-606)Gag>Aag	p.E202K	MYLK2_ENST00000375985.4_Missense_Mutation_p.E202K			Q9H1R3	MYLK2_HUMAN	myosin light chain kinase 2	202					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CATCCTGGCAGAGAGCCAGAA	0.597000													26	63					0	0	1	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90577477	90577477	+	RNA	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:90577477G>C	ENST00000551025.1	+	0	5905							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		GGATGCATCTGAGCAAGATAT	0.408000													34	52					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142569636	142569636	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:142569636C>T	ENST00000359396.3	-	15	2247	c.2002G>A	c.(2002-2004)Gag>Aag	p.E668K		NM_018646.3	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	668					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					CAGCCCAGCTCTAGTTTTTCC	0.582000													17	57					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61926588	61926588	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:61926588C>T	ENST00000280772.2	-	22	2736	c.2545G>A	c.(2545-2547)Gat>Aat	p.D849N	ANK3_ENST00000460468.1_Missense_Mutation_p.D16N|ANK3_ENST00000503366.1_Missense_Mutation_p.D832N|ANK3_ENST00000373827.2_Missense_Mutation_p.D843N	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ATACCTTCATCATCAGACATA	0.333000													24	60					0	0	1	0	0
ZDHHC3	51304	broad.mit.edu	37	3	45000761	45000761	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:45000761G>C	ENST00000296127.3	-	2	441	c.168C>G	c.(166-168)ctC>ctG	p.L56L	ZDHHC3_ENST00000424952.2_Silent_p.L56L|ZDHHC3_ENST00000342790.4_Silent_p.L56L	NM_016598.2	NP_057682.1	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3	56						Golgi membrane|integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		ACTCCGCATAGAGGACCAGAA	0.537000													9	100					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103207108	103207108	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:103207108C>T	ENST00000428762.1	-	32	4846	c.4687G>A	c.(4687-4689)Gac>Aac	p.D1563N	RELN_ENST00000424685.2_Missense_Mutation_p.D1563N|RELN_ENST00000343529.5_Missense_Mutation_p.D1563N	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1563					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGTGGCAGGTCAATGGAAATG	0.478000													33	73					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105406884	105406884	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:105406884C>T	ENST00000333244.5	-	7	15023	c.14904G>A	c.(14902-14904)aaG>aaA	p.K4968K	AHNAK2_ENST00000557457.1_5'UTR	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4968						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGTTTCCTTCTTCGGGGACC	0.532000													13	23					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881142	228881142	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:228881142C>T	ENST00000392056.3	-	7	4474	c.4428G>A	c.(4426-4428)gtG>gtA	p.V1476V	SPHKAP_ENST00000344657.5_Silent_p.V1476V	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1476						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GACAAGCGCTCACGGCTGTGT	0.463000													23	107					0	0	1	0	0
TRIM59	286827	broad.mit.edu	37	3	160156793	160156793	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:160156793C>T	ENST00000543469.1	-	2	393	c.179G>A	c.(178-180)aGa>aAa	p.R60K	TRIM59_ENST00000309784.4_Missense_Mutation_p.R60K|RP11-432B6.3_ENST00000483754.1_Missense_Mutation_p.R60K			Q8IWR1	TRI59_HUMAN	tripartite motif containing 59	60						integral to membrane|intracellular	zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|urinary_tract(3)	15			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AGTAATACTTCTGCAATTAGG	0.358000													20	89					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216272903	216272903	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:216272903C>T	ENST00000354785.4	-	17	2815	c.2446G>A	c.(2446-2448)Gac>Aac	p.D816N	FN1_ENST00000443816.1_Missense_Mutation_p.D816N|FN1_ENST00000446046.1_Missense_Mutation_p.D816N|FN1_ENST00000356005.4_Missense_Mutation_p.D816N|FN1_ENST00000346544.3_Missense_Mutation_p.D816N|FN1_ENST00000432072.2_Missense_Mutation_p.D816N|FN1_ENST00000359671.1_Missense_Mutation_p.D816N|FN1_ENST00000345488.5_Missense_Mutation_p.D816N|FN1_ENST00000357009.2_Missense_Mutation_p.D816N|FN1_ENST00000357867.4_Missense_Mutation_p.D816N|FN1_ENST00000336916.4_Missense_Mutation_p.D816N|FN1_ENST00000421182.1_Missense_Mutation_p.D816N|FN1_ENST00000323926.6_Missense_Mutation_p.D816N			P02751	FINC_HUMAN	fibronectin 1	816	Fibronectin type-III 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACAGTCGTGTCAGGAGGGGCA	0.502000													5	80					0	0	1	0	0
C12orf55	144535	broad.mit.edu	37	12	97157932	97157932	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:97157932C>T	ENST00000524981.4	+	59	8067	c.8044C>T	c.(8044-8046)Cct>Tct	p.P2682S						chromosome 12 open reading frame 55																		TTTTTAGCCTCCTCTCAGAAG	0.343000													6	23					0	0	1	0	0
TOP3A	7156	broad.mit.edu	37	17	18188586	18188586	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:18188586C>T	ENST00000321105.5	-	15	1961	c.1747G>A	c.(1747-1749)Gac>Aac	p.D583N	TOP3A_ENST00000540524.1_Missense_Mutation_p.D113N|TOP3A_ENST00000542570.1_Missense_Mutation_p.D488N	NM_004618.3	NP_004609.1	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	583					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(2)|urinary_tract(1)	36						GCCCGGAGGTCAGGCTTAGAC	0.517000													17	61					0	0	1	0	0
TMEM87B	84910	broad.mit.edu	37	2	112858208	112858208	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:112858208C>T	ENST00000283206.4	+	15	1755	c.1386C>T	c.(1384-1386)ttC>ttT	p.F462F	TMEM87B_ENST00000463427.1_3'UTR	NM_032824.2	NP_116213.1	Q96K49	TM87B_HUMAN	transmembrane protein 87B	462						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)	19						GATATGCCTTCATGCCCTTAA	0.274000													7	68					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47406995	47406995	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:47406995G>A	ENST00000310638.4	-	1	142	c.111C>T	c.(109-111)ctC>ctT	p.L37L	CYP4A11_ENST00000457840.2_5'UTR|CYP4A11_ENST00000371904.4_Silent_p.L37L|CYP4A11_ENST00000462347.1_Silent_p.L37L|CYP4A11_ENST00000371905.1_Silent_p.L37L	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	37					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	TGTGCAGGTAGAGCTGAACTG	0.602000													7	130					0	0	1	0	0
CRAT	1384	broad.mit.edu	37	9	131860309	131860309	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:131860309C>T	ENST00000318080.2	-	11	1741	c.1447G>A	c.(1447-1449)Gat>Aat	p.D483N	RP11-247A12.1_ENST00000434250.1_RNA	NM_000755.3|NM_001257363.1	NP_000746|NP_001244292.1	P43155	CACP_HUMAN	carnitine O-acetyltransferase	483					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(2)	13				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	CTGGAGTCATCCATGGCCTTG	0.597000													9	129					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29221167	29221167	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:29221167G>C	ENST00000321990.4	+	21	5674	c.5296G>C	c.(5296-5298)Gac>Cac	p.D1766H		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1766					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGCTAATTTAGAGTAAGTCTT	0.294000													4	31					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202703015	202703015	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:202703015C>G	ENST00000367265.3	-	23	4588		c.e23-1		KDM5B_ENST00000367264.2_Splice_Site	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B						negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						GAGTTGCCATCTGAAAAAGAG	0.493000													20	143					0	0	1	0	0
ZNF587	84914	broad.mit.edu	37	19	58370965	58370965	+	Silent	SNP	C	C	T	rs146642070		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:58370965C>T	ENST00000339656.5	+	3	1367	c.1185C>T	c.(1183-1185)ctC>ctT	p.L395L	ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF587_ENST00000419854.1_Silent_p.L352L|ZNF814_ENST00000597832.1_Intron|ZNF587_ENST00000423137.1_Silent_p.L394L|ZNF814_ENST00000595295.1_Intron	NM_001204817.1|NM_032828.3	NP_001191746.1|NP_116217.1	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		AGGGCAACCTCGTTCACCATC	0.468000													103	129					0	0	1	0	0
HNRNPU	3192	broad.mit.edu	37	1	245019785	245019785	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:245019785G>C	ENST00000444376.2	-	10	2063	c.1829C>G	c.(1828-1830)cCa>cGa	p.P610R	HNRNPU_ENST00000283179.9_Missense_Mutation_p.P629R	NM_004501.3|NM_031844.2	NP_004492.2|NP_114032.2	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	629					CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			CGCATGTTCTGGTAGGTCTTT	0.378000													20	137					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41007694	41007694	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:41007694G>A	ENST00000324545.8	+	12	2125	c.1492G>A	c.(1492-1494)Gat>Aat	p.D498N	USP9X_ENST00000378308.2_Missense_Mutation_p.D498N	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TGCAGAAGATGATAAAGATGG	0.433000													6	84					0	0	1	0	0
CNST	163882	broad.mit.edu	37	1	246810440	246810440	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:246810440G>A	ENST00000366513.4	+	9	1206		c.e9-1		CNST_ENST00000483271.1_Splice_Site|CNST_ENST00000366512.3_Splice_Site	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein						positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						TTCATCTTTAGAGAGTAAAAC	0.383000											OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	75					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15468887	15468887	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:15468887C>T	ENST00000341776.2	+	5	852	c.608C>T	c.(607-609)tCa>tTa	p.S203L	JARID2_ENST00000541660.1_Missense_Mutation_p.S165L|JARID2_ENST00000397311.3_Missense_Mutation_p.S31L	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	203					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AACAATGCTTCATCTTCATGC	0.468000													16	51					0	0	1	0	0
EPHX4	253152	broad.mit.edu	37	1	92528691	92528691	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:92528691G>A	ENST00000370383.4	+	7	1035	c.937G>A	c.(937-939)Gag>Aag	p.E313K		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	313						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(3)|lung(8)	12						CATGGAGGTTGAGATGGCTGA	0.418000													52	81					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3887485	3887485	+	Missense_Mutation	SNP	C	C	T	rs145675446	by1000genomes	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:3887485C>T	ENST00000319331.3	+	2	1921	c.1160C>T	c.(1159-1161)aCc>aTc	p.T387I	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	387	LRRCT.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TCCAACAAAACCAACATCCGC	0.493000													42	56					0	0	1	0	0
GABRG3	2567	broad.mit.edu	37	15	27725975	27725975	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:27725975G>C	ENST00000555083.1	+	6	897	c.754G>C	c.(754-756)Gag>Cag	p.E252Q	GABRG3_ENST00000333743.6_Intron	NM_001270873.1	NP_001257802.1	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 3	0					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(23)|skin(1)|upper_aerodigestive_tract(4)	42		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		AAAAGCCAGAGAGGCCTAAGG	0.413000													4	11					0	0	1	0	0
GAD1	2571	broad.mit.edu	37	2	171678617	171678617	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:171678617G>A	ENST00000358196.3	+	3	653	c.103G>A	c.(103-105)Gtg>Atg	p.V35M	GAD1_ENST00000344257.5_Missense_Mutation_p.V35M|GAD1_ENST00000429023.1_3'UTR|GAD1_ENST00000375272.1_Missense_Mutation_p.V35M	NM_000817.2	NP_000808.2	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 (brain, 67kDa)	35					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(15)|ovary(1)|urinary_tract(2)	35					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CTGGTGCGGCGTGGCCCATGG	0.627000													4	12					0	0	1	0	0
TGOLN2	10618	broad.mit.edu	37	2	85554310	85554310	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:85554310G>A	ENST00000377386.3	-	2	1007	c.545C>T	c.(544-546)tCg>tTg	p.S182L	TGOLN2_ENST00000444342.2_Missense_Mutation_p.S182L|TGOLN2_ENST00000409232.3_Missense_Mutation_p.S182L|TGOLN2_ENST00000282120.2_Missense_Mutation_p.S84L|TGOLN2_ENST00000409015.1_Missense_Mutation_p.S182L|TGOLN2_ENST00000398263.2_Missense_Mutation_p.S182L			O43493	TGON2_HUMAN	trans-golgi network protein 2	182	14 X 14 AA tandem repeats.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding										GTCCGCACCCGACTTATTAGG	0.592000													217	378					0	0	1	0	0
GDPD3	79153	broad.mit.edu	37	16	30123730	30123730	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30123730C>A	ENST00000406256.3	-	5	757	c.380G>T	c.(379-381)gGg>gTg	p.G127V		NM_024307.2	NP_077283.2	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain containing 3	127	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)	11						CCGGTCTGACCCGTGAGCAAA	0.602000											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	93					1.33987e-11	1.44248e-11	1	1	0
GRTP1	79774	broad.mit.edu	37	13	114009747	114009747	+	Translation_Start_Site	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:114009747G>T	ENST00000326039.3	-	0	4				GRTP1-AS1_ENST00000423246.1_RNA|GRTP1-AS1_ENST00000419199.1_RNA|GRTP1_ENST00000375431.4_Silent_p.V77V|GRTP1_ENST00000375430.4_Silent_p.V77V			Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1							intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GCACCATCCAGACGCGGGCAC	0.662000													21	27					4.96729e-08	5.22459e-08	1	1	0
FANCD2	2177	broad.mit.edu	37	3	10084780	10084780	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:10084780T>G	ENST00000287647.3	+	12	1028	c.935T>G	c.(934-936)tTg>tGg	p.L312W	FANCD2_ENST00000419585.1_Missense_Mutation_p.L312W|FANCD2_ENST00000383806.1_Missense_Mutation_p.L312W|FANCD2_ENST00000383807.1_Missense_Mutation_p.L312W	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	312	Interaction with BRCA2.				DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		CATTGTGTTTTGCCATCACGG	0.428000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				21	63					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430668	43430668	+	RNA	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:43430668C>T	ENST00000406070.2	-	0	1006				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GGTCCTGTTTCATTTCTCGTG	0.498000													49	276					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130290033	130290033	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:130290033G>A	ENST00000358511.6	+	6	2804	c.2773G>A	c.(2773-2775)Gat>Aat	p.D925N	COL6A6_ENST00000453409.2_Missense_Mutation_p.D925N	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	925	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GGAATCCCATGATGCTGATAA	0.567000													13	65					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3672032	3672032	+	Missense_Mutation	SNP	G	G	A	rs139820400		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:3672032G>A	ENST00000294600.2	+	3	538	c.454G>A	c.(454-456)Gag>Aag	p.E152K		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	152										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TTCACCCACTGAGGCCGATTT	0.552000													121	235					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91469117	91469117	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:91469117C>T	ENST00000416354.1	+	4	322	c.250C>T	c.(250-252)Ctg>Ttg	p.L84L	KIF20B_ENST00000260753.4_Silent_p.L84L|KIF20B_ENST00000371728.3_Silent_p.L84L|KIF20B_ENST00000394289.2_Silent_p.L84L			Q96Q89	KI20B_HUMAN	kinesin family member 20B	84	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						TGTGCATATTCTGGATTCACA	0.348000													61	44					0	0	1	0	0
TMCC1	23023	broad.mit.edu	37	3	129546893	129546893	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:129546893C>T	ENST00000393238.3	-	3	669	c.329G>A	c.(328-330)cGa>cAa	p.R110Q	TMCC1_ENST00000426664.2_5'UTR	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	110						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						GGGTGGCACTCGAATCTGCTG	0.552000													31	67					0	0	1	0	0
CINP	51550	broad.mit.edu	37	14	102822155	102822155	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:102822155C>T	ENST00000216756.6	-	3	296	c.256G>A	c.(256-258)Gag>Aag	p.E86K	CINP_ENST00000541568.2_Missense_Mutation_p.E86K|CINP_ENST00000536961.2_Missense_Mutation_p.E101K	NM_032630.2	NP_116019.1	Q9BW66	CINP_HUMAN	cyclin-dependent kinase 2 interacting protein	86					cell cycle|cell division|DNA repair|DNA replication	nucleus	protein binding			large_intestine(2)|lung(2)	4						TCCAGTTCCTCGTTATATTCC	0.443000													16	74					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2939198	2939198	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:2939198C>T	ENST00000378404.2	+	1	1153	c.948C>T	c.(946-948)ctC>ctT	p.L316L		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	316						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		ACCGGCTTCTCAAGGAGCTGG	0.602000													5	109					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	26029159	26029159	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:26029159G>A	ENST00000435504.4	-	4	484	c.191C>T	c.(190-192)tCc>tTc	p.S64F	ASXL2_ENST00000497092.1_5'UTR|ASXL2_ENST00000272341.4_5'UTR|ASXL2_ENST00000336112.4_Missense_Mutation_p.S36F			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	64					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCACCTCTGGAGTTTGTGTG	0.388000													4	32					0	0	1	0	0
TIGD4	201798	broad.mit.edu	37	4	153691920	153691920	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:153691920C>T	ENST00000304337.2	-	2	1057	c.237G>A	c.(235-237)ctG>ctA	p.L79L		NM_145720.3	NP_663772.1	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	79	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			breast(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.093)					AAGCAGTTCTCAGTCTTTTTC	0.338000													44	102					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11067485	11067485	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:11067485C>T	ENST00000287766.4	+	9	1297	c.876C>T	c.(874-876)atC>atT	p.I292I	SLC6A1_ENST00000536032.1_Silent_p.I114I	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	292					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CAACCCAGATCTTCTTCTCAT	0.517000													8	136					0	0	1	0	0
PANK2	80025	broad.mit.edu	37	20	3869936	3869936	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3869936G>A	ENST00000316562.4	+	1	195	c.189G>A	c.(187-189)ccG>ccA	p.P63P	PANK2_ENST00000497424.1_Intron	NM_153638.2	NP_705902.2	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2	63					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						TTAGGGAGCCGACTGGACGCG	0.692000													3	5					0	0	1	0	0
CSNK1G2	1455	broad.mit.edu	37	19	1969891	1969891	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:1969891G>A	ENST00000255641.8	+	2	615	c.120G>A	c.(118-120)ctG>ctA	p.L40L		NM_001319.6	NP_001310.3	P78368	KC1G2_HUMAN	casein kinase 1, gamma 2	40					sphingolipid metabolic process|Wnt receptor signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(1)|lung(3)|prostate(1)|skin(1)|stomach(1)	8		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGGGTCCTGATGGTGGGCC	0.706000													8	4					0	0	1	0	0
HTR3E	285242	broad.mit.edu	37	3	183824447	183824447	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:183824447C>G	ENST00000415389.2	+	9	1803	c.1337C>G	c.(1336-1338)tCt>tGt	p.S446C	HTR3E_ENST00000440596.2_Missense_Mutation_p.S472C|HTR3E_ENST00000425359.2_Missense_Mutation_p.S431C|HTR3E_ENST00000436361.2_Missense_Mutation_p.S446C|HTR3E_ENST00000335304.2_Missense_Mutation_p.S461C	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	446						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			ATGGCCTCCTCTATCATCACC	0.592000													32	83					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76892492	76892492	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:76892492C>T	ENST00000409709.3	+	23	3033	c.2761C>T	c.(2761-2763)Cgg>Tgg	p.R921W	MYO7A_ENST00000409893.1_Missense_Mutation_p.R921W|MYO7A_ENST00000458637.2_Missense_Mutation_p.R921W|MYO7A_ENST00000409619.2_Missense_Mutation_p.R910W	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	921					actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GGCCGCTCGGCGGAAGAAGGA	0.617000													6	10					0	0	1	0	0
CHMP2A	27243	broad.mit.edu	37	19	59063429	59063429	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:59063429C>T	ENST00000600118.1	-	3	897	c.472G>A	c.(472-474)Gag>Aag	p.E158K	CHMP2A_ENST00000312547.2_Missense_Mutation_p.E158K|CHMP2A_ENST00000601220.1_Missense_Mutation_p.E158K			O43633	CHM2A_HUMAN	charged multivesicular body protein 2A	158	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	7		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TACCTCTCCTCTTCATCTTCC	0.512000													12	204					0	0	1	0	0
LRP8	7804	broad.mit.edu	37	1	53755276	53755276	+	Translation_Start_Site	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:53755276C>T	ENST00000465675.1	-	0	347				LRP8_ENST00000354412.3_Silent_p.E110E|LRP8_ENST00000371454.2_Silent_p.E110E|LRP8_ENST00000306052.6_Silent_p.E110E|RP4-784A16.2_ENST00000421637.1_RNA|LRP8_ENST00000347547.2_Silent_p.E110E			Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor						cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(1)	21						CATCAGGACACTCCTCCTCGC	0.592000													5	14					0	0	1	0	0
PAXBP1	94104	broad.mit.edu	37	21	34134491	34134491	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:34134491C>T	ENST00000331923.4	-	4	976	c.787G>A	c.(787-789)Gat>Aat	p.D263N	PAXBP1_ENST00000290178.4_Missense_Mutation_p.D263N|PAXBP1_ENST00000472588.1_5'UTR	NM_016631.3	NP_057715.2			PAX3 and PAX7 binding protein 1																		TCTTCATCATCACTGGCATCA	0.403000													8	105					0	0	1	0	0
COG5	10466	broad.mit.edu	37	7	106924162	106924162	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:106924162C>G	ENST00000393603.2	-	13	1693	c.1422G>C	c.(1420-1422)ttG>ttC	p.L474F	COG5_ENST00000297135.3_Missense_Mutation_p.L474F|COG5_ENST00000347053.3_Missense_Mutation_p.L474F	NM_001161520.1	NP_001154992.1	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5	474					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|skin(4)|stomach(1)	40						GTGAGTCTTTCAAAGCCTTTT	0.368000													20	104					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13695543	13695543	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:13695543C>T	ENST00000202816.1	-	14	2641	c.2534G>A	c.(2533-2535)aGa>aAa	p.R845K		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	845	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TTGCTTTTTTCTTGCTTGAAA	0.308000													4	57					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111318975	111318975	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:111318975C>G	ENST00000308208.5	+	7	970	c.728C>G	c.(727-729)tCt>tGt	p.S243C	CCDC63_ENST00000545036.1_Missense_Mutation_p.S203C|CCDC63_ENST00000552694.1_Missense_Mutation_p.S164C|CCDC63_ENST00000550317.1_3'UTR	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	243										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						AAGGACACCTCTCAGTACAAC	0.552000													3	36					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147733647	147733647	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:147733647G>A	ENST00000370460.2	+	2	654	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K	AFF2_ENST00000342251.3_Intron|AFF2_ENST00000370457.5_Intron|AFF2_ENST00000370458.1_Intron	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	59					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CAAGGTAGCTGAATATGTATG	0.358000													5	81					0	0	1	0	0
ZNF202	7753	broad.mit.edu	37	11	123597577	123597577	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:123597577C>T	ENST00000336139.4	-	8	1437	c.1075G>A	c.(1075-1077)Gag>Aag	p.E359K	ZNF202_ENST00000529691.1_Missense_Mutation_p.E359K|ZNF202_ENST00000530393.1_Missense_Mutation_p.E359K			O95125	ZN202_HUMAN	zinc finger protein 202	359					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		GGATTGTCCTCAAAGACTATT	0.433000													79	134					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16180768	16180768	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:16180768C>T	ENST00000399408.2	+	18	2555	c.2380C>T	c.(2380-2382)Ccc>Tcc	p.P794S	ABCC1_ENST00000349029.5_Intron|ABCC1_ENST00000399410.3_Missense_Mutation_p.P794S|ABCC1_ENST00000346370.5_Intron|ABCC1_ENST00000345148.5_Missense_Mutation_p.P794S|ABCC1_ENST00000351154.5_Missense_Mutation_p.P735S			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	794	ABC transporter 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CTTCGATGATCCCCTCTCAGC	0.592000													8	75					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64395311	64395311	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:64395311C>A	ENST00000262043.3	+	4	2028	c.1688C>A	c.(1687-1689)tCt>tAt	p.S563Y	PHF3_ENST00000393387.1_Missense_Mutation_p.S563Y|PHF3_ENST00000509330.1_Missense_Mutation_p.S563Y			Q92576	PHF3_HUMAN	PHD finger protein 3	563					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AGTTGCAATTCTGGGGTTAAA	0.343000													26	39					8.24728e-16	8.97138e-16	1	1	0
ZNF585B	92285	broad.mit.edu	37	19	37676275	37676275	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:37676275C>T	ENST00000532828.2	-	5	2415	c.2164G>A	c.(2164-2166)Gag>Aag	p.E722K	ZNF585B_ENST00000312908.5_Missense_Mutation_p.E310K|ZNF585B_ENST00000527838.1_3'UTR|ZNF585B_ENST00000531805.1_Missense_Mutation_p.E667K|CTC-454I21.3_ENST00000585860.2_Intron	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	722					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCCCACACTCAGCACACACG	0.463000													18	121					0	0	1	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43515225	43515225	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:43515225C>T	ENST00000430334.3	-	12	3303	c.3170G>A	c.(3169-3171)tGa>tAa	p.*1057*	PLEKHM1_ENST00000580404.1_5'UTR|PLEKHM1_ENST00000421073.2_Silent_p.*968*	NM_014798.2	NP_055613.1	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 1	0					intracellular signal transduction	cytoplasm	metal ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26	Renal(3;0.0405)					AGATGGGCATCAGGCGAAAAT	0.627000													5	42					0	0	1	0	0
SPTY2D1	144108	broad.mit.edu	37	11	18636604	18636604	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:18636604G>C	ENST00000336349.5	-	3	1452	c.1217C>G	c.(1216-1218)tCa>tGa	p.S406*		NM_194285.2	NP_919261.2	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	406	Ser-rich.									breast(4)|cervix(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|skin(1)|stomach(1)	30						CTCAGGTCCTGAGCTGGAGCT	0.592000													11	70					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70200458	70200458	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:70200458G>A	ENST00000253925.7	+	17	2430	c.2215G>A	c.(2215-2217)Gaa>Aaa	p.E739K	AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Missense_Mutation_p.E739K	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	739					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity	p.E739K(1)		breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CATAAAGTGTGAAACCTCCCC	0.532000													5	50					0	0	1	0	0
TRIM16	10626	broad.mit.edu	37	17	15532172	15532172	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:15532172C>T	ENST00000578237.1	-	11	2307	c.1452G>A	c.(1450-1452)gaG>gaA	p.E484E	TRIM16_ENST00000416464.2_Silent_p.E354E|TRIM16_ENST00000579219.1_3'UTR|RP11-385D13.1_ENST00000455584.2_Intron|TRIM16_ENST00000577886.1_Silent_p.E268E|TRIM16_ENST00000336708.7_Silent_p.E484E					tripartite motif containing 16											breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)	19				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		TGAGTGGGGTCTCCATGTCAC	0.552000													21	80					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144889748	144889748	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:144889748C>G	ENST00000356994.2	-	16	2158	c.2152G>C	c.(2152-2154)Gag>Cag	p.E718Q	SCRIB_ENST00000320476.3_Missense_Mutation_p.E718Q|SCRIB_ENST00000377533.3_Missense_Mutation_p.E637Q	NM_182706.4	NP_874365	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	718	Interaction with ARHGEF7.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CGAGCAGGCTCTATCAGCAGG	0.617000													7	84					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582453	136582453	+	Missense_Mutation	SNP	C	C	T	rs141900019		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:136582453C>T	ENST00000531224.1	-	12	2959	c.2707G>A	c.(2707-2709)Gag>Aag	p.E903K	BCLAF1_ENST00000392348.2_Missense_Mutation_p.E852K|BCLAF1_ENST00000527759.1_Missense_Mutation_p.E901K|BCLAF1_ENST00000353331.4_Missense_Mutation_p.E852K|BCLAF1_ENST00000031135.9_Missense_Mutation_p.E121K|BCLAF1_ENST00000527536.1_Missense_Mutation_p.E854K|BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000530767.1_Missense_Mutation_p.E730K	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	903					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCCATGGTCTCTTCTTCATCT	0.373000													15	291					0	0	1	0	0
PDLIM3	27295	broad.mit.edu	37	4	186423477	186423477	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:186423477C>T	ENST00000284770.5	-	8	1139	c.1066G>A	c.(1066-1068)Gac>Aac	p.D356N	PDLIM3_ENST00000284771.6_Missense_Mutation_p.D308N|PDLIM3_ENST00000284767.5_3'UTR	NM_014476.5	NP_055291.2	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain 3	356						sarcomere	zinc ion binding			breast(2)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		GTGACCGTGTCATAGCCCTCT	0.557000													45	86					0	0	1	0	0
ACCS	84680	broad.mit.edu	37	11	44098828	44098828	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:44098828G>A	ENST00000263776.8	+	7	990		c.e7-1		ACCS_ENST00000432284.2_Splice_Site|ACCS_ENST00000533208.1_Intron	NM_001127219.1|NM_032592.3	NP_001120691.1|NP_115981.1	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)								1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(4)|endometrium(3)|large_intestine(11)|lung(15)|ovary(1)|skin(1)	35						CCTGCCCCCAGAGGCTTTCCT	0.577000													21	91					0	0	1	0	0
POMGNT2	84892	broad.mit.edu	37	3	43122498	43122498	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:43122498G>A	ENST00000344697.2	-	2	771	c.426C>T	c.(424-426)ttC>ttT	p.F142F	POMGNT2_ENST00000441964.1_Silent_p.F142F	NM_032806.5	NP_116195.2			protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)																		GCTTGGGCATGAAGCGCAGGG	0.617000													11	95					0	0	1	0	0
GJA1	2697	broad.mit.edu	37	6	121768780	121768780	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:121768780C>A	ENST00000282561.3	+	2	944	c.787C>A	c.(787-789)Caa>Aaa	p.Q263K		NM_000165.3	NP_000156.1	P17302	CXA1_HUMAN	gap junction protein, alpha 1, 43kDa	263					cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(2)|large_intestine(10)|liver(2)|lung(13)|ovary(2)	33				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CTGTGGGTCTCAAAAATATGC	0.517000													21	87					4.96729e-08	5.22459e-08	1	1	0
HSD17B7P2	158160	broad.mit.edu	37	10	38652442	38652442	+	RNA	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:38652442C>T	ENST00000494540.1	+	0	432					NR_003086.1																						TTCATATGTTCTCCACAGCTG	0.428000													22	12					0	0	1	0	0
PSIP1	11168	broad.mit.edu	37	9	15486887	15486887	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:15486887C>T	ENST00000380733.4	-	5	674	c.331G>A	c.(331-333)Gaa>Aaa	p.E111K	PSIP1_ENST00000380738.4_Missense_Mutation_p.E111K|PSIP1_ENST00000397519.2_Missense_Mutation_p.E111K|PSIP1_ENST00000380715.1_Missense_Mutation_p.E111K|PSIP1_ENST00000380716.4_Missense_Mutation_p.E111K			O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1	111					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(2)|endometrium(2)|kidney(1)|lung(3)|prostate(1)	9				GBM - Glioblastoma multiforme(50;2.38e-06)		TCCTTTTCTTCAACTTCAACA	0.318000													37	59					0	0	1	0	0
CNDP2	55748	broad.mit.edu	37	18	72186206	72186206	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:72186206G>C	ENST00000324262.4	+	11	1549	c.1233G>C	c.(1231-1233)ttG>ttC	p.L411F	CNDP2_ENST00000324301.8_Missense_Mutation_p.L327F|CNDP2_ENST00000579847.1_Missense_Mutation_p.L411F	NM_018235.2	NP_060705.2	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2 (metallopeptidase M20 family)	411						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(5)|ovary(2)|skin(2)|stomach(3)	24		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		AGCCAGACTTGACCAGGGAAG	0.557000													36	32					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15580402	15580402	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:15580402G>A	ENST00000292609.4	-	4	1811	c.1682C>T	c.(1681-1683)tCc>tTc	p.S561F	PGLYRP2_ENST00000340880.4_Intron			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	0					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						TGTGTAGACGGAGGGGCGGCG	0.692000													3	1					0	0	1	0	0
DKK4	27121	broad.mit.edu	37	8	42232338	42232338	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:42232338G>A	ENST00000220812.2	-	3	542	c.356C>T	c.(355-357)cCa>cTa	p.P119L		NM_014420.2	NP_055235.1	Q9UBT3	DKK4_HUMAN	dickkopf WNT signaling pathway inhibitor 4	119					multicellular organismal development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region				NS(1)|endometrium(1)|large_intestine(7)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	14	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|Lung(22;0.00597)|LUSC - Lung squamous cell carcinoma(45;0.024)			TTCCTGGACTGGGTGCCCAGT	0.443000													71	222					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52520475	52520475	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:52520475G>T	ENST00000216286.5	-	5	1250	c.1251C>A	c.(1249-1251)aaC>aaA	p.N417K	NID2_ENST00000541773.1_Missense_Mutation_p.N364K	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	417						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					GGATGCTTCCGTTTTCGGGGT	0.557000													26	83					1.5548e-18	1.69636e-18	1	1	0
MRM1	79922	broad.mit.edu	37	17	34964210	34964210	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:34964210C>T	ENST00000250156.7	+	3	980	c.741C>T	c.(739-741)ctC>ctT	p.L247L	MRM1_ENST00000585770.1_Silent_p.L52L	NM_024864.3	NP_079140.2	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	247					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		TGGAGTTCCTCTGGGAACGGC	0.612000													15	87					0	0	1	0	0
ANXA11	311	broad.mit.edu	37	10	81932588	81932588	+	Silent	SNP	T	T	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:81932588T>C	ENST00000438331.1	-	4	512	c.30A>G	c.(28-30)ccA>ccG	p.P10P	ANXA11_ENST00000537102.1_5'UTR|ANXA11_ENST00000422982.3_Silent_p.P10P|ANXA11_ENST00000265447.4_Silent_p.P10P|ANXA11_ENST00000372231.3_Silent_p.P10P|ANXA11_ENST00000360615.4_Silent_p.P10P|ANXA11_ENST00000535999.1_Silent_p.P10P	NM_145869.1	NP_665876.1	P50995	ANX11_HUMAN	annexin A11	10					cell cycle|cytokinesis, completion of separation|phagocytosis|response to calcium ion	azurophil granule|melanosome|midbody|nuclear envelope|nucleoplasm|phagocytic vesicle|specific granule|spindle	calcium-dependent phospholipid binding|calcium-dependent protein binding|S100 alpha binding			endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|urinary_tract(1)	17	Prostate(51;0.00985)|all_epithelial(25;0.0951)		Colorectal(32;0.109)			GGTAGCCACCTGGGGGCGGGG	0.617000													27	61					0	0	1	0	0
XPO5	57510	broad.mit.edu	37	6	43521164	43521164	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43521164C>T	ENST00000265351.7	-	14	1728	c.1518G>A	c.(1516-1518)atG>atA	p.M506I	XPO5_ENST00000424378.2_5'UTR	NM_020750.2	NP_065801.1	Q9HAV4	XPO5_HUMAN	exportin 5	506					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(4)|lung(10)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	34	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			AAAAAAGAGTCATGGCTTCCC	0.403000													3	12					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77473256	77473256	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:77473256G>A	ENST00000560626.2	-	4	1488	c.1013C>T	c.(1012-1014)tCa>tTa	p.S338L	PEAK1_ENST00000312493.4_Missense_Mutation_p.S338L|PEAK1_ENST00000558305.1_Missense_Mutation_p.S338L			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	338	Ser-rich.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										GGAGTCAGATGACACCATGCT	0.418000													5	97					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133053363	133053363	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:133053363C>G	ENST00000262283.5	-	9	1072	c.973G>C	c.(973-975)Gag>Cag	p.E325Q	OC90_ENST00000254627.3_Missense_Mutation_p.E129Q|OC90_ENST00000443356.2_Missense_Mutation_p.E129Q|OC90_ENST00000603859.1_Missense_Mutation_p.E129Q			Q02509	OC90_HUMAN	otoconin 90	129	Phospholipase A2-like 2.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CAGTCCATCTCAGCGGCCTCC	0.587000													21	81					0	0	1	0	0
ATP11B	23200	broad.mit.edu	37	3	182577088	182577088	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:182577088G>A	ENST00000323116.5	+	12	1401	c.1141G>A	c.(1141-1143)Gaa>Aaa	p.E381K		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	381					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TCTGTATCATGAAGAATCAGA	0.328000													16	22					0	0	1	0	0
ZPBP2	124626	broad.mit.edu	37	17	38027018	38027018	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:38027018G>T	ENST00000377940.3	+	2	263	c.124G>T	c.(124-126)Gaa>Taa	p.E42*	ZPBP2_ENST00000584588.1_Nonsense_Mutation_p.E64*|ZPBP2_ENST00000348931.4_Nonsense_Mutation_p.E64*	NM_198844.2	NP_942141.2	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2	64					binding of sperm to zona pellucida	extracellular region				kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			TTCTAAAAAAGAAATAGTGGA	0.284000													5	58					3.59834e-05	3.71523e-05	1	1	0
MRGPRF	116535	broad.mit.edu	37	11	68773711	68773711	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:68773711C>T	ENST00000309099.6	-	3	449	c.67G>A	c.(67-69)Gag>Aag	p.E23K	MRGPRF_ENST00000441623.1_Missense_Mutation_p.E23K	NM_145015.4	NP_659452.3	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	23						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.E23*(1)		endometrium(3)|lung(4)	7			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TCCGGGGCCTCGCTCAGGCCA	0.667000													16	36					0	0	1	0	0
EPRS	2058	broad.mit.edu	37	1	220208271	220208271	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:220208271C>T	ENST00000366923.3	-	3	485	c.216G>A	c.(214-216)ctG>ctA	p.L72L		NM_004446.2	NP_004437.2	P07814	SYEP_HUMAN	glutamyl-prolyl-tRNA synthetase	72					glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding	p.L72L(1)		breast(2)|endometrium(11)|kidney(2)|large_intestine(13)|lung(24)|ovary(1)|prostate(3)|skin(2)|stomach(2)|urinary_tract(3)	63				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	TATGTTCCATCAGATTAGAGC	0.363000													45	71					0	0	1	0	0
CRTC2	200186	broad.mit.edu	37	1	153923847	153923847	+	Silent	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:153923847G>T	ENST00000368633.1	-	11	1420	c.1293C>A	c.(1291-1293)ccC>ccA	p.P431P	CRTC2_ENST00000368630.3_Silent_p.P111P	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	431					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGGGGCTGAGGGGCACACGGC	0.632000													7	24					2.7689e-08	2.92495e-08	1	1	0
CHST12	55501	broad.mit.edu	37	7	2473142	2473142	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:2473142G>A	ENST00000258711.6	+	2	1003	c.868G>A	c.(868-870)Gag>Aag	p.E290K		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	290					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CTCGGCGCGCGAGGCCTTCCG	0.652000													11	99					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179421813	179421813	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:179421813C>A	ENST00000589042.1	-	330	88292	c.88068G>T	c.(88066-88068)tgG>tgT	p.W29356C	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.W26788C|TTN_ENST00000342175.6_Missense_Mutation_p.W20483C|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.W27715C|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.W20416C|TTN_ENST00000460472.2_Missense_Mutation_p.W20291C|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	27715	Ig-like 134.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGTTGTTGCCATGAAAGGC	0.443000													15	17					1.5739e-10	1.67714e-10	1	1	0
MTMR8	55613	broad.mit.edu	37	X	63488550	63488550	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:63488550G>A	ENST00000374852.3	-	14	2049	c.1982C>T	c.(1981-1983)tCt>tTt	p.S661F	MTMR8_ENST00000453546.1_Intron	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	661						nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						AGTGGCCTCAGAGATGTCCAT	0.567000													4	32					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144879302	144879302	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:144879302G>A	ENST00000369359.4	-	30	4594	c.4556C>T	c.(4555-4557)tCa>tTa	p.S1519L	PDE4DIP_ENST00000313382.9_Missense_Mutation_p.S1339L|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.S1383L|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.S1519L|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.S1383L			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1383					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ACTTGTAACTGAGAGGGACCG	0.502000			T	PDGFRB	MPD								58	220					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147869504	147869504	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:147869504G>C	ENST00000361727.3	+	18	3460	c.2944G>C	c.(2944-2946)Gag>Cag	p.E982Q	CNTNAP2_ENST00000538075.1_Missense_Mutation_p.E41Q	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	982	EGF-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CAAATGCCTAGAGAGATACCA	0.473000										HNSCC(39;0.1)			26	119					0	0	1	0	0
ODAM	54959	broad.mit.edu	37	4	71063726	71063726	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:71063726C>G	ENST00000396094.2	+	4	275	c.227C>G	c.(226-228)tCt>tGt	p.S76C		NM_017855.3	NP_060325.3	A1E959	ODAM_HUMAN	odontogenic, ameloblast asssociated	76	Gln-rich.				biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(3)|skin(2)	20						TCCCAGTTCTCTTTATCAGCT	0.478000													40	144					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153593628	153593628	+	Splice_Site	SNP	C	C	G	rs112123120		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:153593628C>G	ENST00000422373.1	-	11	1816		c.e11-1		FLNA_ENST00000360319.4_Splice_Site|FLNA_ENST00000344736.4_Splice_Site|FLNA_ENST00000369850.3_Splice_Site	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha						actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCTCTCCCTCTGCCAAGACA	0.627000													4	74					0	0	1	0	0
TOR1AIP1	26092	broad.mit.edu	37	1	179887135	179887135	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:179887135G>C	ENST00000606911.2	+	10	1704	c.1513G>C	c.(1513-1515)Gat>Cat	p.D505H	TOR1AIP1_ENST00000528443.2_Missense_Mutation_p.D506H|TOR1AIP1_ENST00000435319.4_Missense_Mutation_p.D384H|TOR1AIP1_ENST00000271583.3_Missense_Mutation_p.D521H			Q5JTV8	TOIP1_HUMAN	torsin A interacting protein 1							integral to membrane|nuclear inner membrane				breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	18						GGCCTTCAAAGATGTAGCCTT	0.428000													8	140					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84199455	84199455	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:84199455G>A	ENST00000378553.5	+	7	1054	c.930G>A	c.(928-930)gaG>gaA	p.E310E	DNAAF1_ENST00000334315.5_Silent_p.E310E|DNAAF1_ENST00000563818.1_3'UTR	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	310					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						AGCAGTGGGAGAGCAGGGAGC	0.522000													9	91					0	0	1	0	0
SPATA31A7	26165	broad.mit.edu	37	9	65508179	65508179	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:65508179C>T	ENST00000355045.2	-	2	232	c.204G>A	c.(202-204)cgG>cgA	p.R68R		NM_015667.2	NP_056482.2			SPATA31 subfamily A, member 7																		GCCTCCGCCTCCGCCCTACTG	0.527000													20	166					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13919382	13919382	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:13919382C>G	ENST00000265104.4	-	7	982	c.878G>C	c.(877-879)aGa>aCa	p.R293T		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	293	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTTGGAGAGTCTTTTTTTCCA	0.517000									Kartagener syndrome				31	202					0	0	1	0	0
WFDC10A	140832	broad.mit.edu	37	20	44258532	44258532	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:44258532A>T	ENST00000372643.3	+	1	368	c.80A>T	c.(79-81)aAg>aTg	p.K27M	WFDC9_ENST00000326000.1_Intron	NM_080753.2	NP_542791.1	Q9H1F0	WF10A_HUMAN	WAP four-disulfide core domain 10A	27						extracellular region	serine-type endopeptidase inhibitor activity			large_intestine(2)	2		Myeloproliferative disorder(115;0.0122)				CGTGACAAGAAGAGGATGCAG	0.587000											OREG0025983	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	40					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97101052	97101052	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:97101052G>A	ENST00000371247.2	-	28	2849	c.2660C>T	c.(2659-2661)tCc>tTc	p.S887F	SORBS1_ENST00000371249.2_Missense_Mutation_p.S669F|SORBS1_ENST00000371246.2_Missense_Mutation_p.S909F|SORBS1_ENST00000371227.4_Missense_Mutation_p.S841F|SORBS1_ENST00000353505.5_Missense_Mutation_p.S738F|SORBS1_ENST00000393949.1_Missense_Mutation_p.S857F|SORBS1_ENST00000306402.6_Missense_Mutation_p.S634F|SORBS1_ENST00000277982.5_Missense_Mutation_p.S909F|SORBS1_ENST00000371241.1_Missense_Mutation_p.S537F|SORBS1_ENST00000607232.1_Missense_Mutation_p.S1147F|SORBS1_ENST00000361941.3_Missense_Mutation_p.S887F|SORBS1_ENST00000354106.3_Missense_Mutation_p.S857F|SORBS1_ENST00000347291.4_Missense_Mutation_p.S699F|SORBS1_ENST00000371239.1_Missense_Mutation_p.S664F|SORBS1_ENST00000371245.3_Missense_Mutation_p.S738F			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	887	SH3 2.				focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CTTTCTGAAGGACATTTCTAC	0.468000													6	98					0	0	1	0	0
CCDC171	203238	broad.mit.edu	37	9	15920318	15920318	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:15920318C>G	ENST00000380701.3	+	25	3979	c.3651C>G	c.(3649-3651)atC>atG	p.I1217M	CCDC171_ENST00000486641.2_3'UTR	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	1217																	GCACTAGAATCATGACATTAG	0.338000													8	49					0	0	1	0	0
DNAI2	64446	broad.mit.edu	37	17	72297244	72297244	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:72297244C>T	ENST00000579490.1	+	7	1230	c.1095C>T	c.(1093-1095)atC>atT	p.I365I	DNAI2_ENST00000311014.6_Silent_p.I308I|DNAI2_ENST00000446837.2_Silent_p.I308I|DNAI2_ENST00000307504.5_Silent_p.I165I|DNAI2_ENST00000582036.1_Silent_p.I308I			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2	308					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						TCTTGGACATCACCAAGAAGG	0.547000									Kartagener syndrome				61	78					0	0	1	0	0
LOC643201	643201	broad.mit.edu	37	5	175572124	175572124	+	RNA	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:175572124C>A	ENST00000515403.1	-	0	2993				RP11-826N14.4_ENST00000510029.1_lincRNA	NR_036494.1																						AGGTTTACTTCCTGAAGAATG	0.413000													6	6					8.12818e-05	8.3804e-05	1	1	0
SMARCA1	6594	broad.mit.edu	37	X	128599886	128599886	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:128599886G>C	ENST00000371122.4	-	22	2881	c.2752C>G	c.(2752-2754)Caa>Gaa	p.Q918E	SMARCA1_ENST00000371121.3_Missense_Mutation_p.Q906E|SMARCA1_ENST00000371123.1_Missense_Mutation_p.Q906E	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	918					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						CGTTCAATTTGAGCCATAATT	0.328000													16	58					0	0	1	0	0
ZNF230	7773	broad.mit.edu	37	19	44514752	44514752	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:44514752G>C	ENST00000429154.2	+	5	789	c.561G>C	c.(559-561)caG>caC	p.Q187H		NM_006300.3	NP_006291.2	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)|stomach(3)|urinary_tract(2)	22		Prostate(69;0.0352)				GTATTCACCAGAGAGTTCACT	0.458000													53	125					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22156691	22156691	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:22156691G>C	ENST00000397126.4	-	4	1293	c.1145C>G	c.(1144-1146)tCa>tGa	p.S382*	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACTAAGGGTTGAGGGCCACTT	0.368000													12	60					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5904318	5904318	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:5904318C>T	ENST00000378961.4	+	4	1732	c.1528C>T	c.(1528-1530)Cac>Tac	p.H510Y		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	510						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						TAGCTCCCATCACACAGCTGA	0.483000													5	89					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5237174	5237174	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:5237174G>A	ENST00000274181.7	+	14	2254	c.2116G>A	c.(2116-2118)Gag>Aag	p.E706K	ADAMTS16_ENST00000513709.1_Intron	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	706	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TCCATGCTCGGAGGATAGCCG	0.378000													23	93					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77471894	77471894	+	Missense_Mutation	SNP	C	C	A	rs34885462	by1000genomes	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:77471894C>A	ENST00000560626.2	-	4	2850	c.2375G>T	c.(2374-2376)aGt>aTt	p.S792I	PEAK1_ENST00000312493.4_Missense_Mutation_p.S792I|PEAK1_ENST00000558305.1_Missense_Mutation_p.S792I			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	792	Pro-rich.		S -> I (in dbSNP:rs34885462).		cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										CTCTTCCACACTGCAAGCTTT	0.498000													4	67					1	1	1	1	0
GIPC1	10755	broad.mit.edu	37	19	14591576	14591576	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:14591576G>A	ENST00000393033.4	-	5	572	c.303C>T	c.(301-303)acC>acT	p.T101T	GIPC1_ENST00000393029.3_Silent_p.T4T|GIPC1_ENST00000393028.1_Silent_p.T4T|GIPC1_ENST00000345425.2_Silent_p.T101T|GIPC1_ENST00000586027.1_Silent_p.T101T|GIPC1_ENST00000591349.1_Silent_p.T4T	NM_005716.3	NP_005707.1	O14908	GIPC1_HUMAN	GIPC PDZ domain containing family, member 1	101					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding			endometrium(1)|lung(4)|upper_aerodigestive_tract(1)	6						GGGTGTTCAGGGTGCAGAACA	0.612000											OREG0025316	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	39					0	0	1	0	0
ACOX1	51	broad.mit.edu	37	17	73945836	73945836	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:73945836C>T	ENST00000537812.1	-	10	1975	c.1327G>A	c.(1327-1329)Gaa>Aaa	p.E443K	ACOX1_ENST00000293217.5_Missense_Mutation_p.E481K|ACOX1_ENST00000301608.4_Missense_Mutation_p.E481K	NM_001185039.1	NP_001171968.1	Q15067	ACOX1_HUMAN	acyl-CoA oxidase 1, palmitoyl	481					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(1)	14						GTTAGGCTTTCGGGGCTGTTG	0.572000													7	55					0	0	1	0	0
TFAP2A	7020	broad.mit.edu	37	6	10404933	10404933	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:10404933G>A	ENST00000379613.3	-	4	834	c.578C>T	c.(577-579)tCc>tTc	p.S193F	TFAP2A_ENST00000482890.1_Missense_Mutation_p.S191F|TFAP2A_ENST00000379608.3_Missense_Mutation_p.S185F|TFAP2A_ENST00000379604.2_Missense_Mutation_p.S191F|TFAP2A_ENST00000497266.1_5'UTR|TFAP2A_ENST00000319516.4_Missense_Mutation_p.S187F			P05549	AP2A_HUMAN	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	191					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding	p.S191C(1)|p.S185C(1)|p.S187C(1)		breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	13	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AGGGATGGCGGAGACGGCATT	0.627000													34	43					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													4	71					0	0	1	0	0
ECH1	1891	broad.mit.edu	37	19	39306959	39306959	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:39306959C>T	ENST00000221418.4	-	8	928	c.696G>A	c.(694-696)atG>atA	p.M232I		NM_001398.2	NP_001389.2			enoyl CoA hydratase 1, peroxisomal											cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	6	all_cancers(60;9.36e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CGTCAGCCATCATCTTGCGGG	0.682000													3	29					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48413872	48413872	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:48413872C>T	ENST00000249598.1	-	2	1155	c.996G>A	c.(994-996)ctG>ctA	p.L332L		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	332					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						AGTTTACCCGCAGGGAGGTCT	0.612000													16	81					0	0	1	0	0
TKTL1	8277	broad.mit.edu	37	X	153557916	153557916	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:153557916C>T	ENST00000369915.3	+	13	1858	c.1669C>T	c.(1669-1671)Cag>Tag	p.Q557*	TKTL1_ENST00000217905.7_Nonsense_Mutation_p.Q297*|TKTL1_ENST00000369912.2_Nonsense_Mutation_p.Q501*	NM_001145933.1|NM_012253.3	NP_001139405.1|NP_036385.3	P51854	TKTL1_HUMAN	transketolase-like 1	557					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			NS(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(5)|prostate(1)|skin(1)|urinary_tract(2)	34	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCTGACATTCAGGTTCATTC	0.542000													8	75					0	0	1	0	0
POLH	5429	broad.mit.edu	37	6	43555015	43555015	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43555015G>A	ENST00000372236.4	+	4	574	c.279G>A	c.(277-279)cgG>cgA	p.R93R	POLH_ENST00000372226.1_Silent_p.R93R|POLH_ENST00000535400.1_Silent_p.R31R	NM_006502.2	NP_006493.1	Q9Y253	POLH_HUMAN	polymerase (DNA directed), eta	93	UmuC.				DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			TTAGGTACCGGGAAGCCAGTG	0.448000								DNA polymerases (catalytic subunits)	Xeroderma Pigmentosum				12	158					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31682680	31682680	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:31682680C>G	ENST00000319386.3	+	11	2245	c.1252C>G	c.(1252-1254)Ctg>Gtg	p.L418V	CCDC129_ENST00000451887.2_Missense_Mutation_p.L592V|CCDC129_ENST00000407970.3_Missense_Mutation_p.L566V|CCDC129_ENST00000409210.1_Missense_Mutation_p.L474V			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	566										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						TGATCATCCTCTGGGGTTTAT	0.517000													12	223					0	0	1	0	0
ZBTB22	9278	broad.mit.edu	37	6	33284067	33284067	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:33284067G>A	ENST00000431845.2	-	2	778	c.627C>T	c.(625-627)ttC>ttT	p.F209F	ZBTB22_ENST00000418724.1_Silent_p.F209F	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						CCCTGGGGCTGAAGTAGTTGC	0.617000													22	35					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24231400	24231400	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:24231400C>G	ENST00000321728.7	+	17	2157	c.1982C>G	c.(1981-1983)tCt>tGt	p.S661C	PRKCB_ENST00000303531.7_3'UTR	NM_212535.2	NP_997700.1	P05771	KPCB_HUMAN	protein kinase C, beta	661	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	GCTGGCTTCTCTTATACTAAC	0.433000													22	54					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	112042115	112042115	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:112042115G>A	ENST00000374566.3	-	2	910	c.393C>T	c.(391-393)ctC>ctT	p.L131L	EPB41L4B_ENST00000374557.4_Silent_p.L131L	NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	131	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGGCAGAGTCGAGGAACTGGA	0.443000													8	43					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130319039	130319039	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:130319039C>T	ENST00000299164.2	+	1	171	c.171C>T	c.(169-171)atC>atT	p.I57I		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	57					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		TTTTTCAGATCACAGCATTTC	0.602000													11	76					0	0	1	0	0
EVI5	7813	broad.mit.edu	37	1	93170221	93170221	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:93170221G>A	ENST00000370331.1	-	3	371	c.362C>T	c.(361-363)tCa>tTa	p.S121L	EVI5_ENST00000540033.1_Missense_Mutation_p.S121L|EVI5_ENST00000543509.1_Missense_Mutation_p.S121L	NM_005665.4	NP_005656.4	O60447	EVI5_HUMAN	ecotropic viral integration site 5	121	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Ser-rich.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(1)|skin(1)	38		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		AGAGGCTGATGAACTCGACAC	0.363000													9	127					0	0	1	0	0
AIM2	9447	broad.mit.edu	37	1	159035839	159035839	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:159035839C>T	ENST00000368130.4	-	4	965	c.677G>A	c.(676-678)cGt>cAt	p.R226H		NM_004833.1	NP_004824.1	O14862	AIM2_HUMAN	absent in melanoma 2	226	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				breast(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(1)	16	all_hematologic(112;0.0429)					ATCTAACACACGTGAGGCGCT	0.393000													59	108					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24896249	24896249	+	Translation_Start_Site	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:24896249G>A	ENST00000407230.1	+	0	484				NCOA1_ENST00000405141.1_Missense_Mutation_p.D91N|NCOA1_ENST00000348332.3_Missense_Mutation_p.D91N|NCOA1_ENST00000406961.1_Missense_Mutation_p.D91N|NCOA1_ENST00000538539.1_Missense_Mutation_p.D91N|NCOA1_ENST00000395856.3_Missense_Mutation_p.D91N|NCOA1_ENST00000288599.5_Missense_Mutation_p.D91N			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1										PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCAACAACTGATGACGATGT	0.348000			T	PAX3	alveolar rhadomyosarcoma								24	103					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1618267	1618267	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:1618267G>A	ENST00000426508.2	-	15	2084	c.1721C>T	c.(1720-1722)tCt>tTt	p.S574F	IFT140_ENST00000439987.2_5'UTR	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	574										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				GCACCGCAGAGAAGCGATGCC	0.672000													6	18					0	0	1	0	0
ADRB2	154	broad.mit.edu	37	5	148207582	148207582	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:148207582C>A	ENST00000305988.4	+	1	1427	c.1188C>A	c.(1186-1188)agC>agA	p.S396R		NM_000024.5	NP_000015	P07550	ADRB2_HUMAN	adrenoceptor beta 2, surface	396					activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(3)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	CTGTGCCTAGCGATAACATTG	0.453000													22	21					6.44725e-10	6.85021e-10	1	1	0
OGDHL	55753	broad.mit.edu	37	10	50944540	50944540	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:50944540C>G	ENST00000374103.4	-	21	2702	c.2617G>C	c.(2617-2619)Gaa>Caa	p.E873Q	OGDHL_ENST00000419399.1_Missense_Mutation_p.E816Q|OGDHL_ENST00000490844.1_5'UTR|OGDHL_ENST00000432695.1_Missense_Mutation_p.E664Q	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	873					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						GCCCCATCTTCAGGAATCACC	0.637000													19	71					0	0	1	0	0
NT5C3A	51251	broad.mit.edu	37	7	33063689	33063689	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:33063689C>G	ENST00000396152.2	-	4	469	c.167G>C	c.(166-168)aGa>aCa	p.R56T	NT5C3A_ENST00000409787.1_Missense_Mutation_p.R56T|NT5C3A_ENST00000242210.7_Missense_Mutation_p.R95T|NT5C3A_ENST00000381626.2_Missense_Mutation_p.R44T|NT5C3A_ENST00000409467.1_Missense_Mutation_p.R44T|NT5C3A_ENST00000405342.1_Missense_Mutation_p.R56T|NT5C3A_ENST00000610140.1_Missense_Mutation_p.R90T|AVL9_ENST00000404479.1_Intron	NM_016489.12	NP_057573.2			5'-nucleotidase, cytosolic IIIA																		ATATGAAAATCTACTGAGTGT	0.338000													5	19					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130843513	130843513	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:130843513C>G	ENST00000357462.5	-	13	1745	c.1652G>C	c.(1651-1653)gGa>gCa	p.G551A	POTEF_ENST00000361163.4_3'UTR|POTEF_ENST00000409914.2_Missense_Mutation_p.G551A|POTEF_ENST00000360967.5_3'UTR			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	551						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						TTCTGGGAATCCGACATGAGT	0.398000													32	16					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	36994259	36994259	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:36994259G>A	ENST00000379242.3	+	7	812	c.510G>A	c.(508-510)caG>caA	p.Q170Q	VIT_ENST00000404084.1_Silent_p.Q148Q|VIT_ENST00000497382.1_5'UTR|VIT_ENST00000379241.3_Silent_p.Q170Q|VIT_ENST00000401530.1_Silent_p.Q170Q|VIT_ENST00000389975.3_Silent_p.Q170Q	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	170						proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				AAGCCTATCAGAGGCCACCTA	0.468000													8	33					0	0	1	0	0
AKNAD1	254268	broad.mit.edu	37	1	109359687	109359687	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:109359687C>T	ENST00000370001.3	-	15	2630	c.2362G>A	c.(2362-2364)Gaa>Aaa	p.E788K	AKNAD1_ENST00000477908.1_5'UTR	NM_152763.4	NP_689976.2	Q5T1N1	AKND1_HUMAN	AKNA domain containing 1	788										breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|prostate(6)|skin(3)|stomach(2)	32						TTTATTTCTTCAGTGCTATCA	0.443000													30	56					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413428	105413428	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:105413428C>G	ENST00000333244.5	-	7	8479	c.8360G>C	c.(8359-8361)aGa>aCa	p.R2787T	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2787						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CAGCTTTGCTCTCGGGGCCTG	0.602000													119	221					0	0	1	0	0
LOXL1	4016	broad.mit.edu	37	15	74240184	74240184	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:74240184G>A	ENST00000261921.7	+	5	1869	c.1543G>A	c.(1543-1545)Gac>Aac	p.D515N	LOXL1_ENST00000567675.1_3'UTR	NM_005576.2	NP_005567.2	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1	515	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10						CTACAATGCGGACATCGACTG	0.597000													10	96					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88450815	88450815	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:88450815G>A	ENST00000261304.2	-	5	611	c.505C>T	c.(505-507)Cag>Tag	p.Q169*	GALC_ENST00000544807.2_Nonsense_Mutation_p.Q113*|GALC_ENST00000393568.4_Nonsense_Mutation_p.Q146*|GALC_ENST00000393569.2_Nonsense_Mutation_p.Q143*|GALC_ENST00000554916.1_5'UTR	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	169					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GCAGTCAGCTGAAGATTGACA	0.453000													18	32					0	0	1	0	0
RBMS3	27303	broad.mit.edu	37	3	29628627	29628627	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:29628627C>G	ENST00000434693.2	+	4	1027	c.327C>G	c.(325-327)gaC>gaG	p.D109E	RBMS3_ENST00000445033.1_Missense_Mutation_p.D110E|RBMS3_ENST00000396583.3_Missense_Mutation_p.D110E|RBMS3_ENST00000456853.1_Missense_Mutation_p.D110E|RBMS3_ENST00000452462.1_Missense_Mutation_p.D110E|RBMS3_ENST00000383766.2_Missense_Mutation_p.D109E|RBMS3_ENST00000383767.2_Missense_Mutation_p.D110E|RBMS3_ENST00000273139.9_Missense_Mutation_p.D110E	NM_001003793.2	NP_001003793.1	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting protein 3	110	RRM 1.					cytoplasm	nucleotide binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	11		Ovarian(412;0.0956)				TAGATTTTGACAGTCCTGCAG	0.403000													5	50					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594772	140594772	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:140594772G>A	ENST00000341948.4	+	1	1264	c.1077G>A	c.(1075-1077)gaG>gaA	p.E359E		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		359	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAATACCTGAGAACGCGCCTG	0.448000													8	178					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21121061	21121061	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:21121061G>C	ENST00000269228.5	-	16	3039	c.2485C>G	c.(2485-2487)Ctg>Gtg	p.L829V	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Missense_Mutation_p.L511V	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	829					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TCCTTTAGCAGAAGTGGAGAA	0.443000													18	186					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82643638	82643638	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:82643638G>A	ENST00000533655.1	+	6	1470	c.1258G>A	c.(1258-1260)Gaa>Aaa	p.E420K	C11orf82_ENST00000430323.2_Missense_Mutation_p.E420K|C11orf82_ENST00000528759.1_3'UTR|C11orf82_ENST00000329143.3_Missense_Mutation_p.E119K|C11orf82_ENST00000525361.1_Intron	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	420					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						GCCATTCTCTGAAAGCCTGAA	0.443000													17	144					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4934149	4934149	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:4934149C>T	ENST00000345988.2	-	22	4596	c.4507G>A	c.(4507-4509)Gag>Aag	p.E1503K	PPL_ENST00000590782.2_Missense_Mutation_p.E1501K	NM_002705.4	NP_002696	O60437	PEPL_HUMAN	periplakin	1503					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TGGACACTCTCGGAGAGCACC	0.652000													4	61					0	0	1	0	0
PORCN	64840	broad.mit.edu	37	X	48372644	48372644	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:48372644G>A	ENST00000367574.4	+	7	995	c.490G>A	c.(490-492)Gag>Aag	p.E164K	PORCN_ENST00000359882.4_Missense_Mutation_p.E240K|PORCN_ENST00000361988.3_Missense_Mutation_p.E235K|PORCN_ENST00000355092.3_Missense_Mutation_p.E240K|PORCN_ENST00000355961.4_Missense_Mutation_p.E241K|PORCN_ENST00000326194.6_Missense_Mutation_p.E246K|PORCN_ENST00000537758.1_Missense_Mutation_p.E246K	NM_001282167.1	NP_001269096.1	Q9H237	PORCN_HUMAN	porcupine homolog (Drosophila)	246					Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GCGAGCCTACGAGAGTGCTGT	0.597000													19	44					0	0	1	0	0
AVEN	57099	broad.mit.edu	37	15	34159807	34159807	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:34159807G>A	ENST00000306730.3	-	5	991	c.862C>T	c.(862-864)Ctg>Ttg	p.L288L		NM_020371.2	NP_065104.1	Q9NQS1	AVEN_HUMAN	apoptosis, caspase activation inhibitor	288					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|stomach(1)	7		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		TTAAGCAACAGATCTAGTTCT	0.488000													32	147					0	0	1	0	0
SNAP25	6616	broad.mit.edu	37	20	10279959	10279959	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:10279959G>C	ENST00000254976.2	+	7	662	c.451G>C	c.(451-453)Gag>Cag	p.E151Q	SNAP25-AS1_ENST00000421143.2_RNA|SNAP25_ENST00000495883.1_3'UTR|SNAP25-AS1_ENST00000453544.1_RNA|SNAP25_ENST00000304886.2_Missense_Mutation_p.E151Q	NM_130811.2	NP_570824.1	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	151	t-SNARE coiled-coil homology 2.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	TGAAAACCTAGAGCAGGTGAG	0.468000													51	167					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24483991	24483991	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:24483991G>A	ENST00000355123.4	-	22	3109	c.2666C>T	c.(2665-2667)tCa>tTa	p.S889L	ITSN2_ENST00000361999.3_Missense_Mutation_p.S862L|ITSN2_ENST00000406921.3_Missense_Mutation_p.S889L	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	889					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGAATAGGTGATACAGATCC	0.343000													20	49					0	0	1	0	0
TIGD4	201798	broad.mit.edu	37	4	153691892	153691892	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:153691892C>A	ENST00000304337.2	-	2	1085	c.265G>T	c.(265-267)Gag>Tag	p.E89*		NM_145720.3	NP_663772.1	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	89	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			breast(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.093)					ATTAATGCCTCTTCCAGATCT	0.363000													53	122					4.37618e-36	4.80329e-36	1	1	0
VPS13B	157680	broad.mit.edu	37	8	100866426	100866426	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:100866426G>A	ENST00000358544.2	+	56	10995	c.10884G>A	c.(10882-10884)gcG>gcA	p.A3628A	VPS13B_ENST00000357162.2_Silent_p.A3603A|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3628					protein transport			p.A3603A(1)|p.A3628A(1)		NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCACCACTGCGAGGCAGCTTG	0.562000													4	47					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21078642	21078642	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:21078642C>T	ENST00000261383.3	-	24	3479	c.3480G>A	c.(3478-3480)ctG>ctA	p.L1160L	DNAH3_ENST00000415178.1_Silent_p.L1160L	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1160	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGTAATCATTCAGCCCTTTCT	0.443000													15	60					0	0	1	0	0
CLRN3	119467	broad.mit.edu	37	10	129676579	129676579	+	Missense_Mutation	SNP	C	C	T	rs35146970	byFrequency	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:129676579C>T	ENST00000368671.3	-	3	677	c.515G>A	c.(514-516)gGa>gAa	p.G172E		NM_152311.3	NP_689524.1	Q8NCR9	CLRN3_HUMAN	clarin 3	172						integral to membrane				endometrium(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6		all_epithelial(44;0.00168)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)|Colorectal(57;0.235)				GTGGGTCGTTCCTTTACTGGT	0.453000													5	116					0	0	1	0	0
MYO1B	4430	broad.mit.edu	37	2	192275892	192275892	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:192275892C>T	ENST00000392318.3	+	27	3114	c.2867C>T	c.(2866-2868)cCa>cTa	p.P956L	MYO1B_ENST00000439065.2_Missense_Mutation_p.P201L|MYO1B_ENST00000339514.4_Missense_Mutation_p.P898L|MYO1B_ENST00000392316.1_Missense_Mutation_p.P927L|MYO1B_ENST00000304164.4_Missense_Mutation_p.P956L	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	956						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity	p.P956Q(1)|p.P898Q(1)		NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GCTTTATACCCATCTAGGTAT	0.358000													21	95					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8585837	8585837	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:8585837C>A	ENST00000377464.1	-	1	161	c.7G>T	c.(7-9)Gat>Tat	p.D3Y	RERE_ENST00000337907.3_Intron|RERE_ENST00000400908.2_Intron|RERE_ENST00000400907.2_Intron			Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	0					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CTGAATGGATCATCCATGACT	0.463000													9	4					1.08611e-07	1.14073e-07	1	1	0
SYTL2	54843	broad.mit.edu	37	11	85438975	85438975	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:85438975G>C	ENST00000359152.5	-	1	96	c.97C>G	c.(97-99)Cag>Gag	p.Q33E	SYTL2_ENST00000525423.1_5'UTR|SYTL2_ENST00000527523.1_Missense_Mutation_p.Q427E|SYTL2_ENST00000316356.4_Missense_Mutation_p.Q476E|SYTL2_ENST00000389960.4_Missense_Mutation_p.Q475E|SYTL2_ENST00000524452.1_Missense_Mutation_p.Q475E|SYTL2_ENST00000528231.1_Missense_Mutation_p.Q475E	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	475	RabBD.				intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CCTGGCACCTGAGATGGCTCA	0.453000													14	27					0	0	1	0	0
PLA2G2E	30814	broad.mit.edu	37	1	20249137	20249137	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:20249137G>C	ENST00000375116.3	-	2	209	c.152C>G	c.(151-153)tCc>tGc	p.S51C		NM_014589.1	NP_055404.1	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE	51					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CGGCCAGTGGGAGCCACCGAT	0.612000													13	80					0	0	1	0	0
PAPD7	11044	broad.mit.edu	37	5	6750570	6750570	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:6750570C>T	ENST00000230859.6	+	10	1193	c.1064C>T	c.(1063-1065)tCa>tTa	p.S355L		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	355	Ser-rich.				cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CTCCTGTCTTCAGGCTCCTCG	0.572000													11	54					0	0	1	0	0
NOMO1	23420	broad.mit.edu	37	16	14989478	14989478	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:14989478G>C	ENST00000287667.7	+	31	3816	c.3645G>C	c.(3643-3645)aaG>aaC	p.K1215N		NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1	1215						integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						GACAAGCCAAGAAACAGAAGA	0.607000													87	515					0	0	1	0	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:2062350C>G	ENST00000280665.6	-	7	835	c.756G>C	c.(754-756)caG>caC	p.Q252H	DCP1B_ENST00000397173.4_Missense_Mutation_p.Q150H|DCP1B_ENST00000540622.1_Missense_Mutation_p.Q126H|DCP1B_ENST00000541700.1_5'UTR	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.552000													4	57					0	0	1	0	0
AJUBA	84962	broad.mit.edu	37	14	23445703	23445703	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:23445703C>G	ENST00000262713.2	-	4	1576	c.1201G>C	c.(1201-1203)Gag>Cag	p.E401Q	AJUBA_ENST00000361265.4_Missense_Mutation_p.E401Q|AJUBA_ENST00000397388.3_5'UTR|RP11-298I3.5_ENST00000555074.1_Intron	NM_032876.4	NP_116265.1	Q96IF1	JUB_HUMAN	ajuba LIM protein	401	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding										CAGCATTTCTCAGCTGCCTCC	0.478000													49	188					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29184080	29184080	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:29184080G>A	ENST00000321990.4	+	8	3121	c.2743G>A	c.(2743-2745)Gaa>Aaa	p.E915K	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	915					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TGCTCTTGGTGAATTTTCAAC	0.353000													19	43					0	0	1	0	0
FOXD2	2306	broad.mit.edu	37	1	47904552	47904552	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:47904552G>A	ENST00000334793.5	+	1	2864	c.745G>A	c.(745-747)Gcg>Acg	p.A249T		NM_004474.3	NP_004465.3	O60548	FOXD2_HUMAN	forkhead box D2	249	Ala-rich.|Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(4)	4				READ - Rectum adenocarcinoma(2;0.0908)		cggggccgcggcggcgggggA	0.771000													11	5					0	0	1	0	0
C18orf54	162681	broad.mit.edu	37	18	51898905	51898905	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:51898905C>T	ENST00000300091.5	+	6	1245	c.913C>T	c.(913-915)Caa>Taa	p.Q305*	C18orf54_ENST00000582188.1_3'UTR|C18orf54_ENST00000382911.4_Nonsense_Mutation_p.Q466*|C18orf54_ENST00000578138.1_Nonsense_Mutation_p.Q84*	NM_173529.4	NP_775800.3	Q8IYD9	CR054_HUMAN	chromosome 18 open reading frame 54	305						extracellular region				breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15				Colorectal(16;0.0206)|READ - Rectum adenocarcinoma(59;0.186)		ATTTAACCTTCAAGCAGTACA	0.338000													25	64					0	0	1	0	0
HPS3	84343	broad.mit.edu	37	3	148868438	148868438	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:148868438G>A	ENST00000296051.2	+	6	1356	c.1216G>A	c.(1216-1218)Gag>Aag	p.E406K	HPS3_ENST00000460120.1_Missense_Mutation_p.E241K	NM_032383.3	NP_115759.2	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3	406						cytoplasm				breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	34			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			AGCTCGTGAGGAGGACCCGTA	0.512000									Hermansky-Pudlak syndrome				11	59					0	0	1	0	0
NASP	4678	broad.mit.edu	37	1	46082055	46082055	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:46082055delC	ENST00000350030.3	+	12	2156	c.2069delC	c.(2068-2070)tcafs	p.S690fs	NASP_ENST00000537798.1_Frame_Shift_Del_p.S626fs|NASP_ENST00000351223.3_Frame_Shift_Del_p.S351fs|NASP_ENST00000530073.1_3'UTR|NASP_ENST00000402363.3_Frame_Shift_Del_p.S692fs|NASP_ENST00000372052.4_Frame_Shift_Del_p.S324fs	NM_002482.3	NP_002473.2	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein (histone-binding)	690					blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	17	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					GGAGGCTCTTCAGTCTCCATG	0.488													79	129	---	---	---	---					
USP33	23032	broad.mit.edu	37	1	78180315	78180315	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:78180315delA	ENST00000370793.1	-	20	2638	c.2292delT	c.(2290-2292)tttfs	p.F764fs	USP33_ENST00000357428.1_Frame_Shift_Del_p.F764fs|USP33_ENST00000370792.3_Frame_Shift_Del_p.F756fs|USP33_ENST00000370794.3_Frame_Shift_Del_p.F733fs	NM_015017.4	NP_055832.3	Q8TEY7	UBP33_HUMAN	ubiquitin specific peptidase 33	764	DUSP 1.				axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	44						GAATACAAAGAAAGTCATTAT	0.368													43	82	---	---	---	---					
KCTD8	386617	broad.mit.edu	37	4	44176909	44176909	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:44176909delC	ENST00000360029.3	-	2	1603	c.1320delG	c.(1318-1320)atgfs	p.M440fs		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	440						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						TACACTTTTTCATTTCTTCTT	0.398										HNSCC(17;0.042)			36	116	---	---	---	---					
CTNND2	1501	broad.mit.edu	37	5	11199639	11199639	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:11199639delC	ENST00000304623.8	-	11	2085	c.1896delG	c.(1894-1896)ctgfs	p.L632fs	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000359640.2_Frame_Shift_Del_p.L632fs|CTNND2_ENST00000458100.2_Frame_Shift_Del_p.L199fs|CTNND2_ENST00000503622.1_Frame_Shift_Del_p.L295fs|CTNND2_ENST00000511377.1_Frame_Shift_Del_p.L541fs	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	632					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CACAGTTTTTCAGGGCAATTT	0.498													59	81	---	---	---	---					
MYLIP	29116	broad.mit.edu	37	6	16144013	16144022	+	Frame_Shift_Del	DEL	TCGTGCTCTT	TCGTGCTCTT	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:16144013_16144022delTCGTGCTCTT	ENST00000349606.4	+	4	707_716	c.203_212delTCGTGCTCTT	c.(202-213)atcgtgctcttgfs	p.IVLL68fs	MYLIP_ENST00000356840.3_Frame_Shift_Del_p.IVLL249fs			Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting protein	249	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			GGGAACAGCATCGTGCTCTTGTTTAAAATG	0.519													40	116	---	---	---	---					
HLA-DRB6	3128	broad.mit.edu	37	6	32521545	32521546	+	RNA	INS	-	-	AAGG	rs144810212	by1000genomes	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:32521545_32521546insAAGG	ENST00000411500.1	-	0	851					NR_001298.1																						TTGGGGAAAGACTTTATCCAGG	0.436													5	4	---	---	---	---					
HIP1R	9026	broad.mit.edu	37	12	123345546	123345546	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:123345546delG	ENST00000253083.4	+	29	2975	c.2850delG	c.(2848-2850)gtgfs	p.V950fs		NM_003959.1	NP_003950.1	O75146	HIP1R_HUMAN	huntingtin interacting protein 1 related	950	I/LWEQ.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			breast(1)|endometrium(5)|kidney(6)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	26	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CCAATGTGGTGGCCTCCACCA	0.637													20	18	---	---	---	---					
SACS	26278	broad.mit.edu	37	13	23915245	23915246	+	In_Frame_Ins	INS	-	-	TTC			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:23915245_23915246insTTC	ENST00000382298.3	-	10	3357_3358	c.2769_2770insGAA	c.(2767-2772)gaattg>gaaGAAttg	p.923_924insE	SACS_ENST00000382292.3_In_Frame_Ins_p.923_924insE|SACS_ENST00000402364.1_In_Frame_Ins_p.173_174insE	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	923					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AATATTGCCAATTCTTGAATAA	0.376													41	96	---	---	---	---					
