Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CA7	766	broad.mit.edu	37	16	66884515	66884515	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:66884515G>A	ENST00000394069.3	+	3	573	c.142G>A	c.(142-144)Gat>Aat	p.D48N	RP11-61A14.1_ENST00000551187.1_RNA|CA7_ENST00000338437.2_Missense_Mutation_p.D104N	NM_001014435.1	NP_001014435.1	P43166	CAH7_HUMAN	carbonic anhydrase VII	104					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(4)	6		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		CAAGAAGCACGATGTGGGTTC	0.617000													40	48					0	0	1	0	0
OTUD6A	139562	broad.mit.edu	37	X	69283220	69283220	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chrX:69283220C>T	ENST00000338352.2	+	1	880	c.846C>T	c.(844-846)ggC>ggT	p.G282G		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	282										autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						CCGCCGGGGGCGTGCTCCCGC	0.642000													9	0					0	0	1	0	0
ARHGAP19-SLIT1	100533184	broad.mit.edu	37	10	98924593	98924593	+	Nonsense_Mutation	SNP	G	G	C	rs149092674	byFrequency	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:98924593G>C	ENST00000453547.2	-	12	1528	c.1529C>G	c.(1528-1530)tCa>tGa	p.S510*	SLIT1_ENST00000371041.3_Silent_p.L84L|SLIT1_ENST00000266058.4_Silent_p.L84L|SLIT1_ENST00000456008.2_5'UTR|SLIT1_ENST00000371070.4_Silent_p.L84L																							GCAGCTGCTTGAGCCCCGCAA	0.607000													78	78					0	0	1	0	0
XKR3	150165	broad.mit.edu	37	22	17280695	17280695	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr22:17280695G>C	ENST00000331428.5	-	3	657	c.555C>G	c.(553-555)atC>atG	p.I185M		NM_175878.3	NP_787074.2	Q5GH77	XKR3_HUMAN	XK, Kell blood group complex subunit-related family, member 3	185						integral to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TAGTGAGACTGATATACATCT	0.368000													63	82					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11221357	11221357	+	Missense_Mutation	SNP	G	G	T	rs72658860	byFrequency	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:11221357G>T	ENST00000558518.1	+	7	1157	c.970G>T	c.(970-972)Ggc>Tgc	p.G324C	LDLR_ENST00000535915.1_Missense_Mutation_p.G283C|LDLR_ENST00000557933.1_Missense_Mutation_p.G324C|LDLR_ENST00000455727.2_Missense_Mutation_p.G156C|LDLR_ENST00000558013.1_Missense_Mutation_p.G324C|LDLR_ENST00000545707.1_Missense_Mutation_p.G197C	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	324	EGF-like 1.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CAACAACGGCGGCTGTTCCCA	0.627000													61	86					5.73332e-34	6.26665e-34	1	1	0
LRRC37A6P	387646	broad.mit.edu	37	10	27535308	27535308	+	RNA	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:27535308G>T	ENST00000574842.1	+	0	255																											GATGACCATCGGTGAGAATAA	0.393000													4	22					0.00909568	0.00913455	1	1	0
MECR	51102	broad.mit.edu	37	1	29528511	29528511	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:29528511C>G	ENST00000373791.3	-	6	844	c.472G>C	c.(472-474)Gag>Cag	p.E158Q	MECR_ENST00000263702.6_Missense_Mutation_p.E234Q	NM_001024732.1|NM_016011.2	NP_001019903|NP_057095.3	Q9BV79	MECR_HUMAN	mitochondrial trans-2-enoyl-CoA reductase	234					fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)	11		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		ATGACATGCTCAGCCCCCAGA	0.498000													52	214					0	0	1	0	0
ATE1	11101	broad.mit.edu	37	10	123683829	123683829	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:123683829G>A	ENST00000369043.3	-	2	208	c.122C>T	c.(121-123)tCc>tTc	p.S41F	ATE1_ENST00000224652.6_Missense_Mutation_p.S41F|ATE1_ENST00000540606.1_Missense_Mutation_p.S34F|ATE1_ENST00000535655.1_5'UTR|ATE1_ENST00000369040.3_Intron|ATE1_ENST00000543447.1_5'UTR	NM_007041.2	NP_008972.2	O95260	ATE1_HUMAN	arginyltransferase 1	41					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				TACTGTCATGGAATGTGCCCA	0.383000													50	54					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144921878	144921878	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:144921878T>C	ENST00000529945.1	-	5	2079	c.1640A>G	c.(1639-1641)cAc>cGc	p.H547R	PDE4DIP_ENST00000313382.9_Missense_Mutation_p.H450R|PDE4DIP_ENST00000369359.4_Missense_Mutation_p.H521R|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.H521R|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.H547R|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.H384R|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.H171R|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.H384R|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.H384R|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.H384R			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	384					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTCACTCTCGTGTGCTGCAGC	0.438000			T	PDGFRB	MPD								130	494					0	0	1	0	0
EFCC1	79825	broad.mit.edu	37	3	128755962	128755962	+	Splice_Site	SNP	T	T	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:128755962T>A	ENST00000436022.2	+	6	1590		c.e6+2		EFCC1_ENST00000480450.1_Splice_Site	NM_024768.2	NP_079044.2			EF-hand and coiled-coil domain containing 1																		CGGGACCTGGTAGGCTCACGG	0.627000													11	20					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141215155	141215155	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:141215155C>T	ENST00000389484.3	-	61	10662	c.9691G>A	c.(9691-9693)Gat>Aat	p.D3231N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3231					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTTTTCCCATCAGTCCAGTAG	0.433000										TSP Lung(27;0.18)			66	73					0	0	1	0	0
LOC81691	81691	broad.mit.edu	37	16	20844402	20844402	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:20844402C>G	ENST00000261377.6	+	13	1549	c.1340C>G	c.(1339-1341)tCt>tGt	p.S447C	AC004381.6_ENST00000348433.6_Missense_Mutation_p.S447C|ERI2_ENST00000564349.1_Intron|AC004381.6_ENST00000564274.1_Missense_Mutation_p.S447C	NM_001199053.1|NM_030941.2	NP_001185982.1|NP_112203.2																					GAACTTCCATCTTCCAGAAAT	0.408000													23	31					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208006	58208006	+	Silent	SNP	C	C	T	rs145861936	byFrequency	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr13:58208006C>T	ENST00000377918.3	+	1	1352	c.1326C>T	c.(1324-1326)atC>atT	p.I442I		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	442	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ACGTGACCATCGTGGCGCGGG	0.597000													35	40					0	0	1	0	0
POLN	353497	broad.mit.edu	37	4	2178046	2178046	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:2178046C>G	ENST00000511885.2	-	9	1548	c.1195G>C	c.(1195-1197)Gag>Cag	p.E399Q	POLN_ENST00000515357.1_5'UTR|POLN_ENST00000382865.1_Missense_Mutation_p.E399Q			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	399					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			TTCAGGTTCTCACGTACATTC	0.378000								DNA polymerases (catalytic subunits)					50	61					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42475104	42475104	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:42475104G>A	ENST00000434000.1	-	9	4389	c.4107C>T	c.(4105-4107)atC>atT	p.I1369I	GPATCH8_ENST00000591680.1_Silent_p.I1447I			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1447						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GCCCAGGATGGATGGCTGAGG	0.602000													16	38					0	0	1	0	0
FBXL6	26233	broad.mit.edu	37	8	145582012	145582012	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:145582012C>T	ENST00000331890.5	-	1	160	c.96G>A	c.(94-96)ccG>ccA	p.P32P	FBXL6_ENST00000455319.2_Silent_p.P32P	NM_012162.2	NP_036294.2	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6	32	F-box.				proteolysis		ubiquitin-protein ligase activity			endometrium(1)|lung(3)|ovary(1)	5	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CCGAGCCCCTCGGCGCCAGCC	0.776000													8	6					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41525889	41525889	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:41525889C>T	ENST00000396942.1	-	39	5373	c.5290G>A	c.(5290-5292)Gaa>Aaa	p.E1764K	ANK1_ENST00000396945.1_Missense_Mutation_p.E1764K|ANK1_ENST00000352337.4_Missense_Mutation_p.E1764K|ANK1_ENST00000289734.7_Missense_Mutation_p.E1764K|ANK1_ENST00000379758.2_Missense_Mutation_p.E1764K|ANK1_ENST00000347528.4_Missense_Mutation_p.E1764K|ANK1_ENST00000265709.8_Missense_Mutation_p.E1805K			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1764	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCGGGCTGTTCTGTCCACGTG	0.587000													41	29					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1677508	1677508	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:1677508C>T	ENST00000252804.4	-	9	975	c.925G>A	c.(925-927)Gag>Aag	p.E309K	PXDN_ENST00000483018.1_5'UTR	NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	309	Ig-like C2-type 1.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TGGTCTGTCTCCTGTGTGTTC	0.517000													97	78					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89349156	89349156	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:89349156G>A	ENST00000301030.4	-	9	4254	c.3794C>T	c.(3793-3795)tCc>tTc	p.S1265F	ANKRD11_ENST00000378330.2_Missense_Mutation_p.S1265F	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1265	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCTCTCCTTGGAATGTTCTTT	0.468000													31	33					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106982927	106982927	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:106982927G>A	ENST00000369701.3	+	20	3015	c.2788G>A	c.(2788-2790)Gag>Aag	p.E930K	SORCS3_ENST00000369699.4_3'UTR	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	930						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AAGAAATAAGGAGGTCAACAT	0.448000													84	94					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52509545	52509545	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:52509545A>G	ENST00000216286.5	-	6	1533	c.1534T>C	c.(1534-1536)Tgc>Cgc	p.C512R	NID2_ENST00000541773.1_Missense_Mutation_p.C459R	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	512	EGF-like 1.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					TTGGATTGGCAGTGGCAGCAG	0.507000													32	43					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12443125	12443125	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:12443125G>C	ENST00000358136.3	+	58	11411	c.11281G>C	c.(11281-11283)Gaa>Caa	p.E3761Q	VPS13D_ENST00000356315.4_Missense_Mutation_p.E3736Q|VPS13D_ENST00000496628.1_3'UTR	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3760					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGTTCCACCTGAACAACAATT	0.433000													50	49					0	0	1	0	0
RECQL4	9401	broad.mit.edu	37	8	145739392	145739392	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:145739392C>T	ENST00000428558.2	-	12	2019	c.1978G>A	c.(1978-1980)Gaa>Aaa	p.E660K	RECQL4_ENST00000532237.1_5'UTR	NM_004260.3	NP_004251.3	O94761	RECQ4_HUMAN	RecQ protein-like 4	660	Helicase ATP-binding.				DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TCAGGCTCTTCAGCCACAGCC	0.657000			"""N, F, S"""			"""osteosarcoma, skin basal and sqamous cell"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Rothmund-Thomson syndrome;RAPADILINO syndrome;Baller-Gerold syndrome				5	6					0	0	1	0	0
MED23	9439	broad.mit.edu	37	6	131915384	131915384	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:131915384C>T	ENST00000403834.3	-	23	3278	c.3105G>A	c.(3103-3105)gcG>gcA	p.A1035A	MED23_ENST00000368068.3_Silent_p.A1029A|MED23_ENST00000479213.1_5'UTR|MED23_ENST00000354577.4_Silent_p.A1035A|MED23_ENST00000368060.3_Silent_p.A1029A|MED23_ENST00000368058.1_Silent_p.A1035A|MED23_ENST00000545957.1_Silent_p.A670A			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	1029					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		AGCCAATGATCGCATGGACGA	0.468000													29	81					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71941313	71941313	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:71941313G>T	ENST00000298229.2	+	9	1292	c.1088G>T	c.(1087-1089)cGc>cTc	p.R363L	INPPL1_ENST00000538751.1_Missense_Mutation_p.R121L|INPPL1_ENST00000541756.1_Missense_Mutation_p.R121L	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	363					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						ACGCACGACCGCAGTGAGCCA	0.692000													17	27					4.7546e-09	4.92217e-09	1	1	0
ARSH	347527	broad.mit.edu	37	X	2936713	2936713	+	Splice_Site	SNP	T	T	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chrX:2936713T>G	ENST00000381130.2	+	5	901		c.e5+2			NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H							integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GGATGGTGGGTAAGTATTCAG	0.408000													25	0					0	0	1	0	0
PER3	8863	broad.mit.edu	37	1	7886665	7886665	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:7886665G>C	ENST00000377532.3	+	16	2307	c.2083G>C	c.(2083-2085)Gag>Cag	p.E695Q	RP3-467L1.4_ENST00000451646.1_RNA|PER3_ENST00000361923.2_Missense_Mutation_p.E687Q			P56645	PER3_HUMAN	period circadian clock 3	687	CSNK1E binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGAAGGAAGAGCAGAATTA	0.478000													20	34					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11300726	11300726	+	Translation_Start_Site	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:11300726G>A	ENST00000397056.1	+	3	194	c.3G>A	c.(1-3)atG>atA	p.M1I	HRH1_ENST00000438284.2_Start_Codon_SNP_p.M1I|HRH1_ENST00000431010.2_Start_Codon_SNP_p.M1I	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	1					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	TTGCGCCAATGAGCCTCCCCA	0.542000													22	20					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15629085	15629085	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:15629085G>A	ENST00000281513.5	-	12	1041	c.1016C>T	c.(1015-1017)tCa>tTa	p.S339L	NBAS_ENST00000441750.1_Missense_Mutation_p.S339L	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	339										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						CAGTTTCCCTGAGAAGTGAAT	0.453000													50	70					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144931522	144931522	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:144931522G>A	ENST00000529945.1	-	1	626	c.187C>T	c.(187-189)Cga>Tga	p.R63*	PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000313431.9_Nonsense_Mutation_p.R63*|PDE4DIP_ENST00000369354.3_Intron|PDE4DIP_ENST00000479408.2_Intron|PDE4DIP_ENST00000369351.3_Intron|PDE4DIP_ENST00000369349.3_Intron|PDE4DIP_ENST00000369356.4_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GTGTCGAATCGATAGATTCGA	0.512000			T	PDGFRB	MPD								54	171					0	0	1	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839626	100839626	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:100839626A>G	ENST00000223114.4	-	6	879	c.713T>C	c.(712-714)tTt>tCt	p.F238S	MOGAT3_ENST00000379423.3_Intron|MOGAT3_ENST00000440203.2_Missense_Mutation_p.F238S	NM_178176.2	NP_835470.1	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	238					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(3)	22	Lung NSC(181;0.168)|all_lung(186;0.215)					CTTAAGTCTAAAGATGTCATT	0.577000													29	27					0	0	1	0	0
KLHL17	339451	broad.mit.edu	37	1	897011	897011	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:897011G>A	ENST00000338591.3	+	3	477	c.370G>A	c.(370-372)Gag>Aag	p.E124K		NM_198317.2	NP_938073.1	Q6TDP4	KLH17_HUMAN	kelch-like family member 17	124	BTB.				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold			central_nervous_system(1)|kidney(2)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCCCGCAGATGAGATGAGCGA	0.637000													12	43					0	0	1	0	0
ARID3A	1820	broad.mit.edu	37	19	972046	972046	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:972046C>G	ENST00000263620.3	+	9	2090	c.1763C>G	c.(1762-1764)tCa>tGa	p.S588*		NM_005224.2	NP_005215.1	Q99856	ARI3A_HUMAN	AT rich interactive domain 3A (BRIGHT-like)	588						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(1)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACATCTACCTCAAATAACTCG	0.706000													12	17					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183713952	183713952	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:183713952C>G	ENST00000511685.1	+	26	6250	c.6127C>G	c.(6127-6129)Ctg>Gtg	p.L2043V	TENM3_ENST00000406950.2_Missense_Mutation_p.L2043V					teneurin transmembrane protein 3																		GCCTATTGATCTGTATCAGTT	0.388000													59	73					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57311165	57311165	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:57311165G>A	ENST00000457912.1	+	3	855	c.855G>A	c.(853-855)gtG>gtA	p.V285V	SMTNL1_ENST00000527972.1_Silent_p.V267V|SMTNL1_ENST00000399154.2_Silent_p.V230V			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	267										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						GGGCAGGGGTGATTCCCAGCT	0.627000													10	7					0	0	1	0	0
H6PD	9563	broad.mit.edu	37	1	9324432	9324432	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:9324432C>G	ENST00000377403.2	+	5	2182	c.1880C>G	c.(1879-1881)tCa>tGa	p.S627*	H6PD_ENST00000602477.1_Nonsense_Mutation_p.S638*	NM_001282587.1|NM_004285.3	NP_001269516.1|NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	627	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	GTCCCACTCTCAGACCCGGAG	0.667000													12	50					0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89651946	89651946	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:89651946G>C	ENST00000268720.5	+	8	1021	c.891G>C	c.(889-891)gaG>gaC	p.E297D	CPNE7_ENST00000319518.8_Missense_Mutation_p.E222D	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	297	C2 2.				lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		GCTGCGAGGAGACAAGGCCTC	0.647000													11	8					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21687270	21687270	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr20:21687270C>A	ENST00000398485.2	+	2	535	c.481C>A	c.(481-483)Ctg>Atg	p.L161M	PAX1_ENST00000444366.2_Missense_Mutation_p.L137M|PAX1_ENST00000460221.1_Intron	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	161	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.L67V(1)		autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						CGGCTCCATTCTGCCCGGGGC	0.647000													40	174					1.62957e-23	1.75263e-23	1	1	0
ACSL5	51703	broad.mit.edu	37	10	114169417	114169417	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:114169417G>A	ENST00000393081.1	+	7	992	c.685G>A	c.(685-687)Gag>Aag	p.E229K	ACSL5_ENST00000354655.4_Missense_Mutation_p.E229K|ACSL5_ENST00000354273.4_Missense_Mutation_p.E229K|ACSL5_ENST00000356116.1_Missense_Mutation_p.E285K|ACSL5_ENST00000369410.3_5'UTR|ACSL5_ENST00000433418.1_Missense_Mutation_p.E229K	NM_203380.1	NP_976314.1	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	229					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		GAGTGGAATTGAGATCTTATC	0.468000													28	117					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135920593	135920593	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:135920593T>G	ENST00000264158.8	+	22	2571	c.2528T>G	c.(2527-2529)aTt>aGt	p.I843S	RAB3GAP1_ENST00000442034.1_Missense_Mutation_p.I843S|RAB3GAP1_ENST00000487003.1_3'UTR|ZRANB3_ENST00000412849.1_Intron|RAB3GAP1_ENST00000539493.1_Missense_Mutation_p.I799S	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	843						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		GAAGCTCTCATTGCCAGAGCT	0.418000													75	79					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45132940	45132940	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:45132940G>T	ENST00000296129.1	-	7	1852	c.1718C>A	c.(1717-1719)tCt>tAt	p.S573Y		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	573						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		CCAGGACACAGAGGTGAGGGA	0.602000													16	11					2.23348e-06	2.292e-06	1	1	0
IFIH1	64135	broad.mit.edu	37	2	163167353	163167353	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:163167353G>A	ENST00000263642.2	-	2	939	c.544C>T	c.(544-546)Ctg>Ttg	p.L182L	IFIH1_ENST00000421365.2_Silent_p.L182L	NM_022168.3	NP_071451.2	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	182	CARD 2.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	39						AGAACATTCAGAAATGCAGAG	0.383000													20	13					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710707	140710707	+	Silent	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:140710707C>G	ENST00000517417.1	+	1	456	c.456C>G	c.(454-456)gtC>gtG	p.V152V	PCDHGA1_ENST00000378105.3_Silent_p.V152V	NM_018912.2	NP_061735.1												p.V152V(1)		breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTACCAGAGTCTCATTGCCTT	0.428000													78	85					0	0	1	0	0
PITHD1	57095	broad.mit.edu	37	1	24106426	24106426	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:24106426G>A	ENST00000246151.4	+	3	426	c.315G>A	c.(313-315)atG>atA	p.M105I		NM_020362.4	NP_065095.2	Q9GZP4	PITH1_HUMAN	PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1	105	PITH.									haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)	6						CCTCTGAGATGAGACTGTAAG	0.428000													23	33					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1801111	1801111	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:1801111G>A	ENST00000340107.4	+	3	496	c.240G>A	c.(238-240)ggG>ggA	p.G80G	FGFR3_ENST00000352904.1_Silent_p.G80G|FGFR3_ENST00000412135.2_Silent_p.G80G|FGFR3_ENST00000260795.2_Silent_p.G80G|FGFR3_ENST00000440486.2_Silent_p.G80G|FGFR3_ENST00000481110.2_Silent_p.G80G	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	80	Ig-like C2-type 1.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ATGGCACAGGGCTGGTGCCCT	0.701000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				23	33					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97181762	97181762	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:97181762C>G	ENST00000371247.2	-	8	586	c.397G>C	c.(397-399)Ggc>Cgc	p.G133R	SORBS1_ENST00000371246.2_Missense_Mutation_p.G133R|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000353505.5_Missense_Mutation_p.G133R|SORBS1_ENST00000277982.5_Missense_Mutation_p.G133R|SORBS1_ENST00000347291.4_Missense_Mutation_p.G124R|SORBS1_ENST00000371227.4_Missense_Mutation_p.G133R|SORBS1_ENST00000371249.2_Missense_Mutation_p.G101R|SORBS1_ENST00000607232.1_Missense_Mutation_p.G101R|SORBS1_ENST00000361941.3_Missense_Mutation_p.G133R|SORBS1_ENST00000354106.3_Missense_Mutation_p.G124R|SORBS1_ENST00000371239.1_Missense_Mutation_p.G101R|SORBS1_ENST00000371245.3_Missense_Mutation_p.G133R|SORBS1_ENST00000306402.6_Missense_Mutation_p.G133R|SORBS1_ENST00000371241.1_Missense_Mutation_p.G92R|SORBS1_ENST00000393949.1_Missense_Mutation_p.G124R			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	133					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CTTCTGTAGCCCTTGGCAGCG	0.527000													17	16					0	0	1	0	0
IFIT5	24138	broad.mit.edu	37	10	91177707	91177707	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:91177707G>A	ENST00000371795.4	+	2	964	c.751G>A	c.(751-753)Gtc>Atc	p.V251I	IFIT5_ENST00000416601.1_Missense_Mutation_p.V203I	NM_012420.2	NP_036552.1	Q13325	IFIT5_HUMAN	interferon-induced protein with tetratricopeptide repeats 5	251							binding			endometrium(1)|large_intestine(4)|lung(4)	9						CCAGCCTTACGTCCTTCGTTA	0.408000													66	42					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74594514	74594514	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:74594514C>G	ENST00000361874.3	-	19	2535	c.2218G>C	c.(2218-2220)Gag>Cag	p.E740Q	DCTN1_ENST00000409438.1_Missense_Mutation_p.E606Q|DCTN1_ENST00000394003.3_Missense_Mutation_p.E733Q|DCTN1_ENST00000409240.1_Missense_Mutation_p.E703Q|DCTN1_ENST00000409567.3_Missense_Mutation_p.E720Q|DCTN1_ENST00000495643.1_5'UTR|DCTN1_ENST00000407639.2_Missense_Mutation_p.E606Q|DCTN1_ENST00000409868.1_Missense_Mutation_p.E723Q	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	740					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						GTACAGTCCTCAGGCTGTTCG	0.527000													21	23					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55591271	55591271	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:55591271C>G	ENST00000373965.2	-	31	4421	c.4027G>C	c.(4027-4029)Gat>Cat	p.D1343H	PCDH15_ENST00000409834.1_Missense_Mutation_p.D947H|PCDH15_ENST00000395432.2_Missense_Mutation_p.D1299H|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395438.1_Missense_Mutation_p.D1336H|PCDH15_ENST00000395445.1_Missense_Mutation_p.D1343H|PCDH15_ENST00000361849.3_Missense_Mutation_p.D1336H|PCDH15_ENST00000395433.1_Missense_Mutation_p.D1314H|PCDH15_ENST00000395430.1_Missense_Mutation_p.D1336H|PCDH15_ENST00000320301.6_Missense_Mutation_p.D1336H|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000414778.1_Missense_Mutation_p.D1341H|PCDH15_ENST00000437009.1_Missense_Mutation_p.D1265H	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1336					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.D1336Y(4)|p.D1341Y(4)		NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTATTGATATCAAGTAGTTTG	0.353000										HNSCC(58;0.16)			22	27					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7600833	7600833	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:7600833G>A	ENST00000221249.6	+	4	473	c.42G>A	c.(40-42)atG>atA	p.M14I	PNPLA6_ENST00000600737.1_Missense_Mutation_p.M53I|CTD-2207O23.10_ENST00000601870.1_3'UTR|PNPLA6_ENST00000414982.3_Missense_Mutation_p.M62I|PNPLA6_ENST00000545201.2_Missense_Mutation_p.M14I|PNPLA6_ENST00000450331.3_Missense_Mutation_p.M14I	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	53					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						TTGGCGTGATGATCGGGGCCG	0.701000													3	10					0	0	1	0	0
MROH7-TTC4	100527960	broad.mit.edu	37	1	55148378	55148378	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:55148378G>A	ENST00000414150.2	+	14	2709	c.2431G>A	c.(2431-2433)Gat>Aat	p.D811N	MROH7_ENST00000454855.2_Missense_Mutation_p.D329N|MROH7_ENST00000409996.1_Missense_Mutation_p.D379N|MROH7_ENST00000545244.1_Missense_Mutation_p.D379N|MROH7_ENST00000339553.5_Missense_Mutation_p.D811N|MROH7_ENST00000421030.2_Missense_Mutation_p.D811N|MROH7_ENST00000395690.2_Missense_Mutation_p.D811N																							GCCCAGCTGTGATGTCCGAGA	0.612000													59	64					0	0	1	0	0
ZNF415	55786	broad.mit.edu	37	19	53619628	53619628	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:53619628G>A	ENST00000594011.1	-	4	332	c.74C>T	c.(73-75)tCt>tTt	p.S25F	ZNF415_ENST00000455735.2_Silent_p.L4L|ZNF415_ENST00000596683.1_5'UTR|ZNF415_ENST00000601493.1_Intron|ZNF415_ENST00000599261.1_Missense_Mutation_p.S25F|ZNF415_ENST00000600574.1_Missense_Mutation_p.S25F|ZNF415_ENST00000595813.1_Missense_Mutation_p.S25F|ZNF415_ENST00000597748.1_Missense_Mutation_p.S25F|ZNF415_ENST00000601215.1_Intron|ZNF415_ENST00000595193.1_Missense_Mutation_p.S25F|ZNF415_ENST00000440291.1_5'UTR|ZNF415_ENST00000243643.4_Missense_Mutation_p.S25F|ZNF415_ENST00000448501.1_Silent_p.L4L|ZNF415_ENST00000597503.1_Missense_Mutation_p.S25F|ZNF415_ENST00000500065.4_Missense_Mutation_p.S25F|ZNF415_ENST00000421033.1_Silent_p.L4L			Q09FC8	ZN415_HUMAN	zinc finger protein 415	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				GBM - Glioblastoma multiforme(134;0.0191)		CCTCTGTGTAGAGTTCAGGCA	0.433000													71	102					0	0	1	0	0
BST1	683	broad.mit.edu	37	4	15709241	15709241	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:15709241G>C	ENST00000382346.3	+	4	517	c.468G>C	c.(466-468)ttG>ttC	p.L156F	BST1_ENST00000265016.4_Missense_Mutation_p.L141F			Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1	141					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)|large_intestine(1)|lung(2)|stomach(3)|urinary_tract(1)	8						CAGATTTCTTGAGCTGGTGTC	0.443000													49	59					0	0	1	0	0
PHF2	5253	broad.mit.edu	37	9	96398772	96398772	+	Silent	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr9:96398772C>G	ENST00000359246.4	+	3	631	c.264C>G	c.(262-264)ctC>ctG	p.L88L	PHF2_ENST00000375376.4_Intron	NM_005392.3	NP_005383.3	O75151	PHF2_HUMAN	PHD finger protein 2	88					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		GCAGCCAGCTCTTCATCAAGG	0.622000													12	0					0	0	1	0	0
POLM	27434	broad.mit.edu	37	7	44121923	44121923	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:44121923T>C	ENST00000242248.5	-	1	216	c.115A>G	c.(115-117)Atg>Gtg	p.M39V	POLM_ENST00000395831.3_Missense_Mutation_p.M39V|POLM_ENST00000335195.6_Missense_Mutation_p.M39V	NM_013284.2	NP_037416.1	Q9NP87	DPOLM_HUMAN	polymerase (DNA directed), mu	39	BRCT.				DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(3)|skin(2)	22						CTGCGACCCATGCGAGGCTCG	0.756000								DNA polymerases (catalytic subunits)					6	12					0	0	1	0	0
LIN54	132660	broad.mit.edu	37	4	83905817	83905817	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:83905817T>C	ENST00000340417.3	-	2	558	c.181A>G	c.(181-183)Att>Gtt	p.I61V	LIN54_ENST00000510557.1_Intron|LIN54_ENST00000446851.2_Intron|LIN54_ENST00000395282.2_Missense_Mutation_p.I61V|LIN54_ENST00000442461.2_Intron|LIN54_ENST00000505397.1_Missense_Mutation_p.I61V|LIN54_ENST00000506560.1_Missense_Mutation_p.I61V|LIN54_ENST00000395283.2_Missense_Mutation_p.I61V	NM_194282.2	NP_919258.2	Q6MZP7	LIN54_HUMAN	lin-54 homolog (C. elegans)	61					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)	14		Hepatocellular(203;0.114)				TCCGTGGAAATGGGCGTGGCT	0.418000													48	61					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2740730	2740730	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr18:2740730C>T	ENST00000320876.6	+	28	3882	c.3544C>T	c.(3544-3546)Cag>Tag	p.Q1182*	RP11-703M24.5_ENST00000583546.1_RNA|SMCHD1_ENST00000261598.8_Nonsense_Mutation_p.Q1182*	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1182					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						GTACGGAAATCAGATTCAAGC	0.299000													16	47					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45462069	45462069	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:45462069C>G	ENST00000303230.4	-	3	947	c.890G>C	c.(889-891)aGa>aCa	p.R297T		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	297						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						ATTAAAAATTCTCACCACTGC	0.398000													24	16					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108489210	108489210	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:108489210G>A	ENST00000408999.3	+	20	4827	c.4750G>A	c.(4750-4752)Gaa>Aaa	p.E1584K	RGPD4_ENST00000354986.4_Missense_Mutation_p.E1584K	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1584					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						TAACAACAGTGAAACTAGTTC	0.368000													181	176					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56300270	56300270	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:56300270C>G	ENST00000443188.1	-	11	3468	c.2758G>C	c.(2758-2760)Gaa>Caa	p.E920Q	NLRP11_ENST00000589093.1_Missense_Mutation_p.E920Q|NLRP11_ENST00000589824.2_Missense_Mutation_p.E866Q|NLRP11_ENST00000592953.1_Missense_Mutation_p.E821Q|NLRP11_ENST00000360133.3_Missense_Mutation_p.E866Q	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	920							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TTGAGTCTTTCTAGTGTTTTG	0.448000													12	69					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53237983	53237983	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:53237983G>A	ENST00000359499.4	-	6	622	c.611C>T	c.(610-612)tCt>tTt	p.S204F	KRT78_ENST00000304620.4_Missense_Mutation_p.S314F			Q8N1N4	K2C78_HUMAN	keratin 78	314	Coil 1B.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						AAGCTGGGCAGACACCTGAAG	0.517000													47	78					0	0	1	0	0
NDUFA13	51079	broad.mit.edu	37	19	19626891	19626891	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:19626891C>T	ENST00000252576.5	+	1	93	c.93C>T	c.(91-93)gtC>gtT	p.V31V	NDUFA13_ENST00000507754.4_5'UTR	NM_015965.6	NP_057049.5			NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)	12						TACCCAGGGTCCGCCGCCAGA	0.607000													24	60					0	0	1	0	0
NOL9	79707	broad.mit.edu	37	1	6604980	6604980	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:6604980C>G	ENST00000377705.5	-	5	915	c.883G>C	c.(883-885)Gaa>Caa	p.E295Q		NM_024654.4	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	295					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(2)|urinary_tract(1)	19	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		CCATCTACTTCTTCTGAATGG	0.408000													45	50					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34112007	34112007	+	Splice_Site	SNP	A	A	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:34112007A>G	ENST00000389232.4	+	77	10827	c.10757A>G	c.(10756-10758)aAg>aGg	p.K3586R	RYR3_ENST00000415757.3_Splice_Site_p.K3581R	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3586					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATGATGGCCAAGGTACACCCA	0.413000													283	162					0	0	1	0	0
EXOC8	149371	broad.mit.edu	37	1	231471482	231471482	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:231471482C>T	ENST00000366645.1	-	1	2116	c.1998G>A	c.(1996-1998)aaG>aaA	p.K666K	EXOC8_ENST00000360394.2_Silent_p.K670K			Q8IYI6	EXOC8_HUMAN	exocyst complex component 8	670					exocytosis|protein transport	growth cone|nucleus	protein binding			cervix(2)|endometrium(1)|large_intestine(2)|liver(1)|lung(5)|prostate(1)|skin(1)|stomach(1)	14	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				TAAAAGCTTTCTTCTCTGGAT	0.448000													145	43					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152287839	152287839	+	Missense_Mutation	SNP	C	C	G	rs114733570	byFrequency	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:152287839C>G	ENST00000368799.1	-	2	129	c.94G>C	c.(94-96)Gag>Cag	p.E32Q	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	32	EF-hand 1.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTTCAGCTCTTTTTTACTC	0.338000									Ichthyosis				32	123					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201052309	201052309	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:201052309G>A	ENST00000362061.3	-	10	1600	c.1374C>T	c.(1372-1374)ctC>ctT	p.L458L	CACNA1S_ENST00000367338.3_Silent_p.L458L	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	458			L -> H (in dbSNP:rs12742169).		axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GGGTCAGCCAGAGAGGCTGGT	0.562000													8	77					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115454166	115454166	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:115454166G>C	ENST00000369522.3	+	18	1732	c.1492G>C	c.(1492-1494)Gag>Cag	p.E498Q	SYCP1_ENST00000369518.1_Missense_Mutation_p.E498Q	NM_001282541.1|NM_003176.2	NP_001269470.1|NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	498				IQLTAITTSEQYYSKEVKDLKTELENEK -> YSYCHYHKW TVLPKRGQRPKLSSKRE (in Ref. 2; BAA22586).	cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTATTCAAAAGAGGTTAAAGA	0.289000													21	16					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55111212	55111212	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:55111212T>C	ENST00000314721.2	+	1	586	c.536T>C	c.(535-537)aTg>aCg	p.M179T		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						GTCTGTGACATGTACCCATTG	0.433000													84	128					0	0	1	0	0
ARNT2	9915	broad.mit.edu	37	15	80847412	80847412	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:80847412C>G	ENST00000533983.1	+	12	1402	c.1063C>G	c.(1063-1065)Ctg>Gtg	p.L355V	ARNT2_ENST00000303329.4_Missense_Mutation_p.L366V|ARNT2_ENST00000527771.1_Missense_Mutation_p.L355V|RP11-379K22.2_ENST00000558208.1_RNA			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	366	PAS 2.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			TTAGGATCTTCTGGGAAAGGA	0.403000													111	55					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72776125	72776125	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr18:72776125G>A	ENST00000299687.5	+	8	6448	c.6448G>A	c.(6448-6450)Gag>Aag	p.E2150K		NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	2150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CGTGACGGAGGAGCTGGTCCA	0.662000													6	6					0	0	1	0	0
BDNF	627	broad.mit.edu	37	11	27679633	27679633	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:27679633G>T	ENST00000525528.1	-	1	1572	c.479C>A	c.(478-480)tCg>tAg	p.S160*	BDNF_ENST00000356660.4_Nonsense_Mutation_p.S160*|BDNF_ENST00000533246.1_Nonsense_Mutation_p.S160*|BDNF_ENST00000530861.1_Nonsense_Mutation_p.S160*|BDNF_ENST00000395980.2_Nonsense_Mutation_p.S160*|BDNF_ENST00000525950.1_Nonsense_Mutation_p.S160*|BDNF-AS_ENST00000530313.1_RNA|BDNF_ENST00000584049.1_5'UTR|BDNF_ENST00000532997.1_Nonsense_Mutation_p.S160*|BDNF_ENST00000395981.3_Nonsense_Mutation_p.S160*|BDNF_ENST00000533131.1_Nonsense_Mutation_p.S160*|BDNF_ENST00000395986.2_Nonsense_Mutation_p.S175*|BDNF-AS_ENST00000502161.2_RNA|BDNF_ENST00000395983.3_Nonsense_Mutation_p.S160*|BDNF_ENST00000420794.1_Nonsense_Mutation_p.S160*|BDNF_ENST00000395978.3_Nonsense_Mutation_p.S160*|BDNF-AS_ENST00000499568.2_RNA|BDNF-AS_ENST00000530686.1_RNA|BDNF-AS_ENST00000532965.1_RNA|BDNF_ENST00000418212.1_Nonsense_Mutation_p.S160*|BDNF-AS_ENST00000499008.3_RNA|BDNF_ENST00000438929.1_Nonsense_Mutation_p.S242*|BDNF-AS_ENST00000501176.2_RNA|BDNF_ENST00000439476.2_Nonsense_Mutation_p.S160*|BDNF_ENST00000314915.6_Nonsense_Mutation_p.S168*|BDNF-AS_ENST00000500662.2_RNA	NM_170735.5	NP_733931.1	P23560	BDNF_HUMAN	brain-derived neurotrophic factor	160						extracellular region	growth factor activity			breast(1)|large_intestine(3)|lung(2)	6						CGTCCCGCCCGACATGTCCAC	0.542000													96	103					2.68873e-43	2.95258e-43	1	1	0
FAM47A	158724	broad.mit.edu	37	X	34148766	34148766	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chrX:34148766G>C	ENST00000346193.3	-	1	1681	c.1630C>G	c.(1630-1632)Cgc>Ggc	p.R544G		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	544										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						AGCTCCGGGCGGAGACTGGAC	0.637000													67	2					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7724658	7724658	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:7724658G>A	ENST00000572933.1	+	73	12573	c.11113G>A	c.(11113-11115)Gaa>Aaa	p.E3705K	DNAH2_ENST00000389173.2_Missense_Mutation_p.E3705K			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3705					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAACATGGATGAATACAACTT	0.493000													26	2					0	0	1	0	0
TAF5	6877	broad.mit.edu	37	10	105128017	105128017	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:105128017C>T	ENST00000369839.3	+	1	294	c.271C>T	c.(271-273)Ccg>Tcg	p.P91S	TAF5_ENST00000351396.4_Missense_Mutation_p.P91S	NM_006951.3	NP_008882.2	Q15542	TAF5_HUMAN	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	91					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)	15		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		CGCCGGCGCTCCGCATGACCG	0.751000													5	5					0	0	1	0	0
FECH	2235	broad.mit.edu	37	18	55226416	55226416	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr18:55226416C>T	ENST00000262093.5	-	7	916	c.765G>A	c.(763-765)gaG>gaA	p.E255E	FECH_ENST00000382873.3_Silent_p.E261E	NM_000140.3|NM_001012515.2	NP_000131.2|NP_001012533.1	P22830	HEMH_HUMAN	ferrochelatase	255					generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	15		Colorectal(73;0.227)				GAATGACCACCTCGCTTCTCT	0.418000													37	49					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53668842	53668842	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:53668842G>C	ENST00000600412.1	-	2	821	c.706C>G	c.(706-708)Caa>Gaa	p.Q236E	ZNF665_ENST00000396424.3_Missense_Mutation_p.Q301E			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	236					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TGTGAATTTTGAGTGAAGCAC	0.423000													53	119					0	0	1	0	0
OR7E24	26648	broad.mit.edu	37	19	9362683	9362683	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:9362683C>G	ENST00000456448.1	+	1	1078	c.964C>G	c.(964-966)Ctg>Gtg	p.L322V		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	322					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						CCTGTGCAGGCTGCATGGCAG	0.468000													26	37					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8471022	8471022	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr9:8471022C>G	ENST00000381196.4	-	28	4020	c.3477G>C	c.(3475-3477)gaG>gaC	p.E1159D	PTPRD_ENST00000356435.5_Missense_Mutation_p.E1159D|PTPRD_ENST00000397606.3_Missense_Mutation_p.E738D|PTPRD_ENST00000537002.1_Missense_Mutation_p.E745D|PTPRD_ENST00000360074.4_Missense_Mutation_p.E1146D|PTPRD_ENST00000397611.3_Missense_Mutation_p.E745D|PTPRD_ENST00000358503.5_Missense_Mutation_p.E1137D|PTPRD_ENST00000355233.5_Missense_Mutation_p.E748D|PTPRD_ENST00000486161.1_Missense_Mutation_p.E748D|PTPRD_ENST00000397617.3_Missense_Mutation_p.E738D|PTPRD_ENST00000540109.1_Missense_Mutation_p.E1159D	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1159					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CATCTGGACTCTCCCATGGCT	0.398000										TSP Lung(15;0.13)			47	53					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:1803568C>G	ENST00000340107.4	+	7	1002	c.746C>G	c.(745-747)tCc>tGc	p.S249C	FGFR3_ENST00000352904.1_Missense_Mutation_p.S249C|FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000412135.2_Missense_Mutation_p.S249C|FGFR3_ENST00000260795.2_Missense_Mutation_p.S249C|FGFR3_ENST00000440486.2_Missense_Mutation_p.S249C|FGFR3_ENST00000481110.2_Missense_Mutation_p.S249C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	249			S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1204)|p.R248_S249del(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.736000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				23	18					0	0	1	0	0
CEP290	80184	broad.mit.edu	37	12	88479849	88479849	+	Silent	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:88479849T>C	ENST00000552810.1	-	34	4747	c.4404A>G	c.(4402-4404)ctA>ctG	p.L1468L	CEP290_ENST00000397838.3_Silent_p.L528L|CEP290_ENST00000309041.7_Silent_p.L1470L|CEP290_ENST00000547691.2_Silent_p.L528L	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	1468					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						CCCGTGTTTCTAGAATTATTC	0.368000													23	9					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62648934	62648934	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:62648934C>G	ENST00000337910.5	-	6	829	c.492G>C	c.(490-492)aaG>aaC	p.K164N	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.K164N	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	164	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					TATCCCCTCTCTTTATGGGCC	0.393000													40	46					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15634297	15634297	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:15634297G>A	ENST00000378076.3	-	22	2571	c.2218C>T	c.(2218-2220)Ctg>Ttg	p.L740L		NM_003638.1	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8	740					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CGGAGGCCCAGGGAATACTAA	0.378000													17	21					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76257335	76257335	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:76257335C>T	ENST00000529032.1	+	19	3768	c.3768C>T	c.(3766-3768)atC>atT	p.I1256I	C11orf30_ENST00000525038.1_Silent_p.I1257I|C11orf30_ENST00000524767.1_Silent_p.I1271I|C11orf30_ENST00000533248.1_Silent_p.I1165I|C11orf30_ENST00000525919.1_Silent_p.I1257I|C11orf30_ENST00000343878.3_Intron|C11orf30_ENST00000334736.3_Silent_p.I1256I|C11orf30_ENST00000524490.1_Silent_p.I1158I			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	1256					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						CAGAAATTATCATCCAGGTAA	0.433000													45	52					0	0	1	0	0
FAM21EP	100421577	broad.mit.edu	37	10	51826512	51826512	+	RNA	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:51826512C>A	ENST00000456967.1	-	0	1051					NR_038275.1																						AGATTTGAGGCAGCTGTATTG	0.463000													5	8					0.0215528	0.0215987	1	1	0
ALDH1L2	160428	broad.mit.edu	37	12	105440730	105440730	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:105440730G>A	ENST00000258494.9	-	14	1844	c.1704C>T	c.(1702-1704)atC>atT	p.I568I	C12orf45_ENST00000548583.1_Intron	NM_001034173.3	NP_001029345.2	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	568	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|prostate(2)|skin(3)|stomach(2)	35						GGGCCTGGTTGATTGGAATAG	0.373000													84	58					0	0	1	0	0
PJA2	9867	broad.mit.edu	37	5	108680496	108680496	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:108680496G>C	ENST00000361189.2	-	8	2028	c.1789C>G	c.(1789-1791)Ctt>Gtt	p.L597V	PJA2_ENST00000361557.3_Missense_Mutation_p.L597V	NM_014819.4	NP_055634.3	O43164	PJA2_HUMAN	praja ring finger 2, E3 ubiquitin protein ligase	597	Interaction with PRKAR1A, PRKAR2A and PRKAR2B.				long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		TCCACTGCAAGAGACTCTAAA	0.413000													56	55					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15496812	15496812	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:15496812G>A	ENST00000341776.2	+	7	1600	c.1356G>A	c.(1354-1356)aaG>aaA	p.K452K	JARID2_ENST00000541660.1_Silent_p.K414K|JARID2_ENST00000397311.3_Silent_p.K280K	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	452					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGGCGGAGAAGCCGCAGTCGC	0.692000													20	17					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183699591	183699591	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:183699591C>A	ENST00000334444.6	-	8	1311	c.1071G>T	c.(1069-1071)aaG>aaT	p.K357N	ABCC5_ENST00000265586.6_Missense_Mutation_p.K357N|ABCC5_ENST00000492216.1_5'UTR	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	357	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CTTCATTCATCTTCTGGACAC	0.403000													24	39					1.10513e-12	1.15682e-12	1	1	0
RBM47	54502	broad.mit.edu	37	4	40439899	40439899	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:40439899C>T	ENST00000319592.4	-	4	1721	c.1012G>A	c.(1012-1014)Gag>Aag	p.E338K	RBM47_ENST00000295971.7_Missense_Mutation_p.E338K|RBM47_ENST00000381795.6_Missense_Mutation_p.E338K|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381793.2_Missense_Mutation_p.E338K|RBM47_ENST00000514014.1_Missense_Mutation_p.E300K			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	338						nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						TGCGCTGCCTCAGCCGCGCCG	0.662000													55	42					0	0	1	0	0
CLK2	1196	broad.mit.edu	37	1	155233140	155233140	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:155233140C>T	ENST00000368361.4	-	13	1684	c.1369G>A	c.(1369-1371)Gaa>Aaa	p.E457K	CLK2_ENST00000361168.5_Missense_Mutation_p.E456K|CLK2_ENST00000497188.1_5'UTR|CLK2_ENST00000536801.1_Missense_Mutation_p.E457K|CLK2_ENST00000355560.4_Missense_Mutation_p.E455K			P49760	CLK2_HUMAN	CDC-like kinase 2	457	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGCATGCTTTCAATCAGATCG	0.557000								Other conserved DNA damage response genes					19	60					0	0	1	0	0
PLOD3	8985	broad.mit.edu	37	7	100859192	100859192	+	Silent	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:100859192C>A	ENST00000223127.3	-	5	1010	c.612G>T	c.(610-612)ctG>ctT	p.L204L		NM_001084.4	NP_001075.1	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	204					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	31	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	TCCCTACCCTCAGTCCTGGGT	0.582000													45	38					2.37825e-27	2.58147e-27	1	1	0
USP24	23358	broad.mit.edu	37	1	55607317	55607317	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:55607317C>T	ENST00000294383.6	-	24	2721	c.2722G>A	c.(2722-2724)Gta>Ata	p.V908I	USP24_ENST00000407756.1_Missense_Mutation_p.V748I	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	908					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						GAGGTTGCTACAGTTGGCATG	0.403000													7	11					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56419205	56419205	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:56419205C>T	ENST00000588751.1	-	7	2424	c.2400G>A	c.(2398-2400)ctG>ctA	p.L800L	NLRP13_ENST00000342929.3_Silent_p.L800L			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	800							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CTTTAAGAATCAGGGGGACAG	0.498000													72	111					0	0	1	0	0
KRTAP1-1	81851	broad.mit.edu	37	17	39197549	39197549	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:39197549G>A	ENST00000306271.4	-	1	164	c.101C>T	c.(100-102)tCc>tTc	p.S34F		NM_030967.2	NP_112229.1	Q07627	KRA11_HUMAN	keratin associated protein 1-1	34			Missing (in allele KAP1.7).|PSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQT SFCGFP -> R (in allele KAP1.6).			extracellular region|keratin filament		p.S34C(6)		NS(2)|endometrium(2)|kidney(5)|lung(4)|prostate(1)	14		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCTGGCAGGAGCTGGTCTC	0.612000													88	146					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53667757	53667757	+	Silent	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:53667757G>C	ENST00000600412.1	-	2	1906	c.1791C>G	c.(1789-1791)gtC>gtG	p.V597V	ZNF665_ENST00000396424.3_Silent_p.V662V			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	597					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TTTGAGTAAAGACCTTGCCAC	0.453000													22	45					0	0	1	0	0
SLC6A8	6535	broad.mit.edu	37	X	152954207	152954207	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chrX:152954207G>C	ENST00000253122.5	+	1	654	c.178G>C	c.(178-180)Gac>Cac	p.D60H		NM_001142805.1|NM_005629.3	NP_001136277.1|NP_005620.1	P48029	SC6A8_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 8	60					creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	GCGCCAGATGGACTTCATCAT	0.736000													23	1					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147128850	147128850	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:147128850G>C	ENST00000282928.4	+	1	1680	c.951G>C	c.(949-951)gaG>gaC	p.E317D		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	317					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E317D(1)		central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						CGCGCTCCGAGAATTTAAAGA	0.567000													41	45					0	0	1	0	0
WDR3	10885	broad.mit.edu	37	1	118486190	118486190	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:118486190C>T	ENST00000349139.5	+	11	1316	c.1269C>T	c.(1267-1269)ttC>ttT	p.F423F		NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3							nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		CTTTGTCATTCAGCTCAGACA	0.413000													22	39					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84581918	84581918	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:84581918G>A	ENST00000286744.5	+	16	1999	c.1775G>A	c.(1774-1776)cGt>cAt	p.R592H	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.R592H	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	592	TSP type-1 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GTGAAGTGCCGTGTGCTCCTC	0.607000													76	67					0	0	1	0	0
OMG	4974	broad.mit.edu	37	17	29623198	29623198	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:29623198G>A	ENST00000247271.4	-	2	413	c.152C>T	c.(151-153)tCt>tTt	p.S51F	NF1_ENST00000356175.3_Intron|NF1_ENST00000358273.4_Intron	NM_002544.4	NP_002535.3	P23515	OMGP_HUMAN	oligodendrocyte myelin glycoprotein	51	LRRNT.				cell adhesion|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|plasma membrane		p.0?(8)|p.?(3)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)|stomach(1)	13		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;1.81e-13)|Epithelial(4;4.04e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.49e-12)|GBM - Glioblastoma multiforme(4;0.121)		TTGCAGTCCAGATGGTAATGT	0.413000													14	110					0	0	1	0	0
ELP5	23587	broad.mit.edu	37	17	7161985	7161985	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:7161985G>A	ENST00000574993.1	+	6	935	c.718G>A	c.(718-720)Gat>Aat	p.D240N	ELP5_ENST00000396628.2_Missense_Mutation_p.D240N|ELP5_ENST00000396627.2_Missense_Mutation_p.D240N|RP1-4G17.5_ENST00000577138.1_Intron|ELP5_ENST00000354429.2_Missense_Mutation_p.D240N|ELP5_ENST00000356683.2_Missense_Mutation_p.D240N					elongator acetyltransferase complex subunit 5																		GCCCTACTCCGATCCTCATAT	0.493000													16	57					0	0	1	0	0
TNFAIP1	7126	broad.mit.edu	37	17	26667448	26667448	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:26667448G>A	ENST00000226225.2	+	3	586	c.319G>A	c.(319-321)Gaa>Aaa	p.E107K	TNFAIP1_ENST00000544907.2_Missense_Mutation_p.E3K|TNFAIP1_ENST00000583213.1_Intron	NM_021137.4	NP_066960.1	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1 (endothelial)	107					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)	12	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		ATTGATGGCTGAAGCAAAGTA	0.537000													129	61					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87448115	87448115	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:87448115G>A	ENST00000268616.4	-	10	1314	c.1097C>T	c.(1096-1098)tCg>tTg	p.S366L		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	366					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		CGGCGGGGCCGAGGGGTTCAG	0.637000													25	61					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195517669	195517669	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:195517669G>A	ENST00000463781.3	-	2	1241	c.782C>T	c.(781-783)tCa>tTa	p.S261L	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.S261L|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	266					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TATCTTCTCTGATGTCATCAT	0.473000													43	36					0	0	1	0	0
OR10P1	121130	broad.mit.edu	37	12	56030900	56030900	+	Silent	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:56030900T>C	ENST00000309675.2	+	1	257	c.225T>C	c.(223-225)acT>acC	p.T75T		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						TCTACACCACTGACATCGTGC	0.597000													66	50					0	0	1	0	0
CDCA4	55038	broad.mit.edu	37	14	105477567	105477567	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:105477567C>T	ENST00000336219.3	-	2	855	c.700G>A	c.(700-702)Gtg>Atg	p.V234M	CDCA4_ENST00000392590.3_Missense_Mutation_p.V234M	NM_017955.3	NP_060425.2	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	234						nucleus				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		ATCTCCACCACGTGGTCCAGC	0.697000													16	19					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49171950	49171950	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:49171950G>A	ENST00000307885.4	-	2	1649	c.955C>T	c.(955-957)Cag>Tag	p.Q319*	ADCY6_ENST00000550422.1_Nonsense_Mutation_p.Q319*|ADCY6_ENST00000357869.3_Nonsense_Mutation_p.Q319*	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	319					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						CGGGTCTCCTGAAAGGCCTGG	0.632000													12	15					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53669014	53669014	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:53669014G>T	ENST00000600412.1	-	2	649	c.534C>A	c.(532-534)ttC>ttA	p.F178L	ZNF665_ENST00000396424.3_Missense_Mutation_p.F243L			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		AAGGTTGACTGAAGACCTTTC	0.403000													58	87					2.23044e-30	2.43226e-30	1	1	0
SPEN	23013	broad.mit.edu	37	1	16262029	16262029	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:16262029G>A	ENST00000375759.3	+	11	9498	c.9294G>A	c.(9292-9294)gtG>gtA	p.V3098V		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3098					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AGGGCGAGGTGAGAATGAACA	0.602000													33	44					0	0	1	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3653353	3653353	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:3653353C>T	ENST00000335312.3	-	7	944	c.856G>A	c.(856-858)Gag>Aag	p.E286K	PIP5K1C_ENST00000589578.1_Missense_Mutation_p.E286K|PIP5K1C_ENST00000539785.1_Missense_Mutation_p.E286K|PIP5K1C_ENST00000587482.1_5'UTR|PIP5K1C_ENST00000537021.1_Missense_Mutation_p.E286K	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	286	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		AGGAGCCCCTCGGGCATGTCC	0.672000													4	71					0	0	1	0	0
USP40	55230	broad.mit.edu	37	2	234420381	234420381	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:234420381G>A	ENST00000251722.6	-	20	2614	c.2497C>T	c.(2497-2499)Ctt>Ttt	p.L833F	USP40_ENST00000409945.1_Missense_Mutation_p.L9F|USP40_ENST00000450966.1_Missense_Mutation_p.L845F|USP40_ENST00000427112.2_Missense_Mutation_p.L833F			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	833					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		GCTTTTCCAAGACACAGTCCC	0.358000													5	17					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127623000	127623000	+	Splice_Site	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:127623000C>T	ENST00000508053.1	-	60	7854	c.6880G>A	c.(6880-6882)Gat>Aat	p.D2294N	FBN2_ENST00000262464.4_Splice_Site_p.D2294N			P35556	FBN2_HUMAN	fibrillin 2	2294	EGF-like 39; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GAGGCCTTACCTTTGCACATC	0.438000													74	81					0	0	1	0	0
CYP2D7	1564	broad.mit.edu	37	22	42537260	42537260	+	RNA	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr22:42537260C>T	ENST00000358097.4	-	0	1160				CYP2D7P1_ENST00000433992.1_RNA																endometrium(1)	1						TCGTGAATCACGGCAGTGGTG	0.577000													6	24					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61271410	61271410	+	Silent	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:61271410C>A	ENST00000424789.2	+	4	274	c.270C>A	c.(268-270)ctC>ctA	p.L90L	AC037445.1_ENST00000581421.1_RNA|AC037445.1_ENST00000435892.1_RNA|TANC2_ENST00000389520.4_Silent_p.L90L	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	90							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CAAACACACTCATGACTCGTC	0.458000													9	38					2.17888e-05	2.22624e-05	1	1	0
TNXB	7148	broad.mit.edu	37	6	32057092	32057092	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:32057092C>G	ENST00000375244.3	-	5	2624	c.2423G>C	c.(2422-2424)aGa>aCa	p.R808T	TNXB_ENST00000375247.2_Missense_Mutation_p.R808T			P22105	TENX_HUMAN	tenascin XB	760	Fibronectin type-III 1.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GGCCAGTCCTCTCTGGTCATA	0.642000													14	17					0	0	1	0	0
HAUS5	23354	broad.mit.edu	37	19	36106234	36106234	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:36106234G>A	ENST00000203166.5	+	6	456	c.431G>A	c.(430-432)cGa>cAa	p.R144Q	HAUS5_ENST00000379045.2_Missense_Mutation_p.R144Q	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	144					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						CATACGCTCCGAGATCCCATG	0.642000													15	11					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1078088	1078088	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:1078088C>T	ENST00000264930.5	-	12	1532	c.1489G>A	c.(1489-1491)Ggc>Agc	p.G497S		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	497					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GCCAGCATGCCGATGACCAGG	0.672000													6	7					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16545237	16545237	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:16545237G>A	ENST00000597937.1	-	7	441	c.437C>T	c.(436-438)tCt>tTt	p.S146F	EPS15L1_ENST00000594975.1_Missense_Mutation_p.S146F|EPS15L1_ENST00000602009.1_5'UTR|EPS15L1_ENST00000535753.2_Missense_Mutation_p.S146F|EPS15L1_ENST00000248070.6_Missense_Mutation_p.S146F|EPS15L1_ENST00000455140.2_Missense_Mutation_p.S146F	NM_001258376.1	NP_001245305.1	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	146	EH 2.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						TTTGTCTCCAGAGAGCAAACC	0.488000													78	144					0	0	1	0	0
API5	8539	broad.mit.edu	37	11	43350367	43350367	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:43350367C>T	ENST00000378852.3	+	9	1176	c.1051C>T	c.(1051-1053)Cac>Tac	p.H351Y	API5_ENST00000534695.1_Intron|API5_ENST00000455725.2_Missense_Mutation_p.H340Y|API5_ENST00000534600.1_Missense_Mutation_p.H351Y|API5_ENST00000420461.2_Missense_Mutation_p.H297Y|RP11-484D2.2_ENST00000526220.1_RNA|API5_ENST00000531273.1_Missense_Mutation_p.H351Y	NM_001142930.1|NM_006595.3	NP_001136402.1|NP_006586.1	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5	351					anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20						GTACAGTTTTCACCAGTTGGG	0.423000													20	66					0	0	1	0	0
PER3	8863	broad.mit.edu	37	1	7886608	7886608	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:7886608G>A	ENST00000377532.3	+	16	2250	c.2026G>A	c.(2026-2028)Gaa>Aaa	p.E676K	RP3-467L1.4_ENST00000451646.1_RNA|PER3_ENST00000361923.2_Missense_Mutation_p.E668K			P56645	PER3_HUMAN	period circadian clock 3	668	CSNK1E binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity	p.E668*(1)		breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		GACCTCGGAAGAATTTAAACA	0.483000													22	45					0	0	1	0	0
CREB3	10488	broad.mit.edu	37	9	35736562	35736562	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr9:35736562C>T	ENST00000353704.2	+	9	1393	c.955C>T	c.(955-957)Ccc>Tcc	p.P319S	CREB3_ENST00000486056.1_3'UTR	NM_006368.4	NP_006359.3	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	343					chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|urinary_tract(1)	9	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		GCCTCAGGCTCCCAGTGCAGA	0.597000											OREG0019176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	96	5					0	0	1	0	0
INIP	58493	broad.mit.edu	37	9	115449877	115449877	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr9:115449877G>C	ENST00000374242.4	-	5	561	c.256C>G	c.(256-258)Caa>Gaa	p.Q86E	INIP_ENST00000374234.1_Silent_p.L25L|INIP_ENST00000497712.2_5'UTR|INIP_ENST00000374238.1_Silent_p.L25L|INIP_ENST00000374236.1_Missense_Mutation_p.Q56E	NM_021218.1	NP_067041.1			INTS3 and NABP interacting protein																		GCAGAGTCTTGAGTGATGAAG	0.368000													58	4					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711496	140711496	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:140711496C>G	ENST00000517417.1	+	1	1245	c.1245C>G	c.(1243-1245)atC>atG	p.I415M	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.I415M	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAACTTATCTCTGGGTACA	0.363000													54	55					0	0	1	0	0
SLC25A17	10478	broad.mit.edu	37	22	41188638	41188638	+	Silent	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr22:41188638G>C	ENST00000435456.2	-	4	358	c.225C>G	c.(223-225)ctC>ctG	p.L75L	SLC25A17_ENST00000544408.1_Silent_p.L38L|SLC25A17_ENST00000542412.1_Intron|SLC25A17_ENST00000491545.1_5'UTR	NM_006358.2	NP_006349.1	O43808	PM34_HUMAN	solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17	75					fatty acid alpha-oxidation	integral to plasma membrane|mitochondrial inner membrane|peroxisomal membrane	adenine nucleotide transmembrane transporter activity|protein binding			central_nervous_system(1)|large_intestine(4)|lung(2)|skin(1)	8						tggagcagcagagactggaaa	0.423000													15	46					0	0	1	0	0
RBM15	64783	broad.mit.edu	37	1	110882102	110882102	+	Silent	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:110882102G>C	ENST00000369784.3	+	1	975	c.75G>C	c.(73-75)acG>acC	p.T25T	RBM15_ENST00000487146.2_Silent_p.T25T|RBM15_ENST00000602849.1_Silent_p.T25T	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	25					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGTGTGAAACGAGCGCGGGGC	0.647000			T	MKL1	acute megakaryocytic leukemia								22	19					0	0	1	0	0
SLC22A11	55867	broad.mit.edu	37	11	64335107	64335107	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:64335107C>T	ENST00000301891.4	+	7	1469	c.1095C>T	c.(1093-1095)ttC>ttT	p.F365F	SLC22A11_ENST00000377585.3_Intron|SLC22A11_ENST00000377581.3_Silent_p.F365F	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	365					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	GGCTGGTCTTCGACCTGCAGA	0.632000													82	109					0	0	1	0	0
GLYR1	84656	broad.mit.edu	37	16	4867693	4867693	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:4867693C>G	ENST00000321919.9	-	10	888	c.812G>C	c.(811-813)gGa>gCa	p.G271A	GLYR1_ENST00000591451.1_Missense_Mutation_p.G271A|GLYR1_ENST00000436648.5_Missense_Mutation_p.G190A|GLYR1_ENST00000381983.3_Missense_Mutation_p.G254A	NM_032569.3	NP_115958	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	271					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						GCCCAAAAATCCTATCCTGAA	0.498000													34	53					0	0	1	0	0
USP33	23032	broad.mit.edu	37	1	78183627	78183627	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:78183627G>T	ENST00000370793.1	-	18	2282	c.1936C>A	c.(1936-1938)Ctt>Att	p.L646I	USP33_ENST00000370792.3_Missense_Mutation_p.L638I|USP33_ENST00000357428.1_Missense_Mutation_p.L646I|USP33_ENST00000370794.3_Missense_Mutation_p.L615I	NM_015017.4	NP_055832.3	Q8TEY7	UBP33_HUMAN	ubiquitin specific peptidase 33	646					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	44						TCCTTAGCAAGAAATGGCTGA	0.388000													72	65					1.10782e-18	1.18067e-18	1	1	0
RFX6	222546	broad.mit.edu	37	6	117198586	117198586	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:117198586G>A	ENST00000332958.2	+	1	164	c.148G>A	c.(148-150)Gaa>Aaa	p.E50K		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	50					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						CCTGGCGGCCGAAGGGCAGCC	0.667000													10	13					0	0	1	0	0
EGR1	1958	broad.mit.edu	37	5	137803577	137803577	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:137803577C>T	ENST00000239938.4	+	2	1711	c.1439C>T	c.(1438-1440)tCg>tTg	p.S480L		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	480					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.S480L(1)		haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			cccggctcctcgacctaccca	0.642000													99	125					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134624536	134624536	+	Splice_Site	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:134624536C>G	ENST00000368586.5	-	56	7602		c.e56-1		TTC40_ENST00000263170.5_Splice_Site	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40											breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						ACCTGGCACTCTGCCGGGACG	0.682000													5	6					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58071466	58071466	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:58071466G>C	ENST00000219271.3	+	2	1038	c.253G>C	c.(253-255)Gag>Cag	p.E85Q		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	85					protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						GGCCCTTGCAGAGATGCAGCG	0.607000													61	63					0	0	1	0	0
NPEPPS	9520	broad.mit.edu	37	17	45669352	45669352	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:45669352G>A	ENST00000322157.4	+	11	1528	c.1291G>A	c.(1291-1293)Gag>Aag	p.E431K	NPEPPS_ENST00000530173.1_Missense_Mutation_p.E427K|NPEPPS_ENST00000525037.1_3'UTR|NPEPPS_ENST00000544660.1_Missense_Mutation_p.E351K	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	431					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						TGAGGTTGATGAGATATTTGA	0.393000													32	77					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803729	185803729	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:185803729C>T	ENST00000302277.6	+	4	4200	c.3606C>T	c.(3604-3606)gtC>gtT	p.V1202V		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1202						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						ACCCTACTGTCATCCCTTTGC	0.438000													117	121					0	0	1	0	0
ZNF595	152687	broad.mit.edu	37	4	59963	59963	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:59963C>G	ENST00000509152.2	+	3	328	c.143C>G	c.(142-144)tCt>tGt	p.S48C	ZNF595_ENST00000526473.2_Missense_Mutation_p.S48C|ZNF595_ENST00000339368.6_3'UTR					zinc finger protein 595											endometrium(5)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)	20		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		TTTGTGATCTCTAACCCAGAC	0.388000													20	134					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157766903	157766903	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:157766903A>G	ENST00000358292.3	-	9	1130	c.1079T>C	c.(1078-1080)aTa>aCa	p.I360T	FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Silent_p.H401H|FCRL1_ENST00000368176.3_Silent_p.H402H	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	0						integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGTCCTCCATATGTGTCCCCA	0.388000													101	28					0	0	1	0	0
LDHAL6B	92483	broad.mit.edu	37	15	59499499	59499499	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:59499499C>T	ENST00000307144.4	+	1	458	c.360C>T	c.(358-360)ttC>ttT	p.F120F	MYO1E_ENST00000288235.4_Intron	NM_033195.2	NP_149972.1	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	120					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)	10					NADH(DB00157)	GCAGCCCTTTCACGAAAATGC	0.423000													59	139					0	0	1	0	0
PA2G4	5036	broad.mit.edu	37	12	56505038	56505038	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:56505038C>G	ENST00000303305.6	+	11	1429	c.1010C>G	c.(1009-1011)cCc>cGc	p.P337R	RP11-603J24.17_ENST00000548595.1_RNA|PA2G4_ENST00000552766.1_Intron	NM_006191.2	NP_006182.2	Q9UQ80	PA2G4_HUMAN	proliferation-associated 2G4, 38kDa	337	Necessary for nucleolar localization.				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			ACCAGTGGTCCCTTCGAGCCT	0.458000													41	36					0	0	1	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947258	57947258	+	Silent	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:57947258C>G	ENST00000335397.3	+	3	658	c.342C>G	c.(340-342)ctC>ctG	p.L114L		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				ACTGCTACCTCTTGGCCCTCA	0.562000													49	39					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004745	75004745	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chrX:75004745G>A	ENST00000373359.2	-	1	334	c.142C>T	c.(142-144)Cag>Tag	p.Q48*		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	48										autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ATTGGCGCCTGAGGGCACTGG	0.592000													41	0					0	0	1	0	0
KXD1	79036	broad.mit.edu	37	19	18677976	18677976	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:18677976G>C	ENST00000602094.1	+	4	1749	c.289G>C	c.(289-291)Gag>Cag	p.E97Q	KXD1_ENST00000599319.1_Missense_Mutation_p.E97Q|KXD1_ENST00000601630.1_Missense_Mutation_p.E116Q|KXD1_ENST00000595073.1_Missense_Mutation_p.E97Q|KXD1_ENST00000598830.1_Missense_Mutation_p.E97Q|KXD1_ENST00000540691.1_Missense_Mutation_p.E97Q|KXD1_ENST00000222307.4_Missense_Mutation_p.E97Q|KXD1_ENST00000539106.1_Missense_Mutation_p.E97Q|KXD1_ENST00000599000.1_Missense_Mutation_p.E97Q			Q9BQD3	CS050_HUMAN	KxDL motif containing 1	97							protein binding										GCAGCACCCAGAGGCCTTCAG	0.637000													13	29					0	0	1	0	0
HIST1H2AM	8336	broad.mit.edu	37	6	27860745	27860745	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:27860745G>A	ENST00000359611.2	-	1	218	c.183C>T	c.(181-183)gcC>gcT	p.A61A	HIST1H3J_ENST00000479986.1_5'UTR	NM_003514.2	NP_003505.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2am	61					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)	14						CCAGGATCTCGGCAGTTAGGT	0.667000													90	110					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162462	90162462	+	RNA	SNP	A	A	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:90162462A>G	ENST00000564451.1	+	0	1815				TUBB8P7_ENST00000567960.1_RNA														p.T398T(1)									ACTGGTACACAGGCGAGGGCA	0.522000													4	116					0	0	1	0	0
SIK3	23387	broad.mit.edu	37	11	116732082	116732082	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:116732082G>A	ENST00000375300.1	-	18	2194	c.2189C>T	c.(2188-2190)tCa>tTa	p.S730L	SIK3_ENST00000292055.4_Missense_Mutation_p.S672L|SIK3_ENST00000542607.1_Missense_Mutation_p.S672L|SIK3_ENST00000488337.1_Intron|SIK3_ENST00000446921.2_Missense_Mutation_p.S730L|SIK3_ENST00000434315.2_Missense_Mutation_p.S571L|SIK3_ENST00000375288.1_Intron			Q9Y2K2	SIK3_HUMAN	SIK family kinase 3	672	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	57						GGGTGGGCTTGAAGGCTGAAT	0.468000											OREG0003492	type=REGULATORY REGION|Gene=BC035583|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	36	49					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26164652	26164652	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr22:26164652G>C	ENST00000335473.7	+	4	1019	c.769G>C	c.(769-771)Gag>Cag	p.E257Q	MYO18B_ENST00000407587.2_Missense_Mutation_p.E257Q|MYO18B_ENST00000536101.1_Missense_Mutation_p.E257Q	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	257						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GAAAGAGGCTGAGCCCCAGGG	0.642000													12	18					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56756452	56756452	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:56756452G>A	ENST00000326855.2	+	1	106	c.64G>A	c.(64-66)Gag>Aag	p.E22K		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	22					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						TGCCCAGCATGAGTTTTGGTG	0.403000													59	69					0	0	1	0	0
FAM84B	157638	broad.mit.edu	37	8	127568858	127568858	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:127568858C>T	ENST00000304916.3	-	2	1232	c.777G>A	c.(775-777)caG>caA	p.Q259Q		NM_174911.4	NP_777571.1	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	259						cytoplasm|plasma membrane	protein binding			lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	5	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			CGCGCCCGATCTGGTCGTTGC	0.692000													13	22					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26174762	26174762	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:26174762G>C	ENST00000264712.3	-	5	2481	c.1902C>G	c.(1900-1902)atC>atG	p.I634M	KIF3C_ENST00000405914.1_Missense_Mutation_p.I634M|KIF3C_ENST00000496378.1_5'UTR	NM_002254.6	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	634	Globular (Potential).				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGAAGTTCTCGATGATTAGGT	0.532000													39	63					0	0	1	0	0
TLE3	7090	broad.mit.edu	37	15	70346823	70346823	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:70346823C>T	ENST00000558939.1	-	16	3166	c.1789G>A	c.(1789-1791)Gat>Aat	p.D597N	TLE3_ENST00000451782.2_Missense_Mutation_p.D594N|TLE3_ENST00000440567.3_Missense_Mutation_p.D587N|TLE3_ENST00000442299.2_Missense_Mutation_p.D589N|TLE3_ENST00000557907.1_Missense_Mutation_p.D589N|TLE3_ENST00000317509.8_Missense_Mutation_p.D585N|TLE3_ENST00000560589.1_Missense_Mutation_p.D541N|TLE3_ENST00000557997.1_Missense_Mutation_p.D589N|TLE3_ENST00000559048.1_Missense_Mutation_p.D597N|TLE3_ENST00000560939.1_Missense_Mutation_p.D599N|TLE3_ENST00000558201.1_Missense_Mutation_p.D603N|TLE3_ENST00000559191.1_Missense_Mutation_p.D178N|TLE3_ENST00000559929.1_Missense_Mutation_p.D607N|TLE3_ENST00000539550.1_Missense_Mutation_p.D524N|TLE3_ENST00000558379.1_Missense_Mutation_p.D592N	NM_001282979.1|NM_001282980.1|NM_001282981.1	NP_001269908.1|NP_001269909.1|NP_001269910.1	Q04726	TLE3_HUMAN	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	597					organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						ATGTTCCCATCGCTGCAGCAG	0.617000													31	104					0	0	1	0	0
EIF3K	27335	broad.mit.edu	37	19	39127542	39127542	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:39127542C>T	ENST00000588934.1	+	5	451	c.368C>T	c.(367-369)tCa>tTa	p.S123L	EIF3K_ENST00000248342.4_Silent_p.I213I|EIF3K_ENST00000592558.1_Silent_p.I187I|EIF3K_ENST00000593149.1_Silent_p.I126I			Q9UBQ5	EIF3K_HUMAN	eukaryotic translation initiation factor 3, subunit K	0					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex|nucleus	protein binding|ribosome binding|translation initiation factor activity		EIF3K/CYP39A1(2)	central_nervous_system(1)|endometrium(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGTCCAGCATCATGGCCTCCT	0.552000													32	140					0	0	1	0	0
CYLD	1540	broad.mit.edu	37	16	50821713	50821713	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:50821713G>A	ENST00000540145.1	+	14	2473	c.2058G>A	c.(2056-2058)ttG>ttA	p.L686L	CYLD_ENST00000311559.9_Silent_p.L686L|CYLD_ENST00000564326.1_Silent_p.L683L|CYLD_ENST00000427738.3_Silent_p.L686L|CYLD_ENST00000566206.1_Silent_p.L683L|RP11-327F22.4_ENST00000564510.1_RNA|CYLD_ENST00000569418.1_Silent_p.L683L|RP11-327F22.4_ENST00000575917.1_RNA|CYLD_ENST00000568704.2_Silent_p.L501L|CYLD_ENST00000398568.2_Silent_p.L683L			Q9NQC7	CYLD_HUMAN	cylindromatosis (turban tumor syndrome)	686					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				AGGAATTCTTGAATATTCTGT	0.254000			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis				10	9					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84200559	84200559	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr9:84200559C>T	ENST00000376499.3	-	18	3053	c.1989G>A	c.(1987-1989)ctG>ctA	p.L663L		NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	663					negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						GGCAGTACCCCAGGGAGAAGA	0.547000													32	2					0	0	1	0	0
CTB-60E11.9	0	broad.mit.edu	37	19	40023495	40023495	+	RNA	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:40023495G>A	ENST00000594676.1	+	0	437																											TGCTGTATGCGAGACCTGCGC	0.602000											OREG0025463	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	23					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183522099	183522099	+	Silent	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:183522099C>G	ENST00000511685.1	+	4	657	c.534C>G	c.(532-534)ggC>ggG	p.G178G	TENM3_ENST00000406950.2_Silent_p.G178G					teneurin transmembrane protein 3																		GCAATCAAGGCCAGTCTACCC	0.388000													91	123					0	0	1	0	0
CUTA	51596	broad.mit.edu	37	6	33385354	33385354	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:33385354G>A	ENST00000374500.5	-	2	349	c.218C>T	c.(217-219)tCg>tTg	p.S73L	CUTA_ENST00000488478.1_Missense_Mutation_p.S54L|CUTA_ENST00000374496.3_Missense_Mutation_p.S31L|CUTA_ENST00000488034.1_Missense_Mutation_p.S54L|CUTA_ENST00000494751.1_Missense_Mutation_p.S31L|CUTA_ENST00000607266.1_Missense_Mutation_p.S31L|CUTA_ENST00000440279.3_Missense_Mutation_p.S31L	NM_001014433.2	NP_001014433.1	O60888	CUTA_HUMAN	cutA divalent cation tolerance homolog (E. coli)	54					protein localization|response to metal ion	membrane	enzyme binding		SLC22A1/CUTA(2)	kidney(1)|lung(3)|urinary_tract(1)	5						CGAGGCCGGCGAGGGCTGGGT	0.632000													42	133					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72049886	72049886	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr13:72049886G>T	ENST00000305425.4	-	9	2394	c.1972C>A	c.(1972-1974)Cag>Aag	p.Q658K	DACH1_ENST00000354591.4_Missense_Mutation_p.Q456K|DACH1_ENST00000359684.2_Missense_Mutation_p.Q710K|DACH1_ENST00000313174.7_Missense_Mutation_p.Q510K	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	708	DACHbox-C.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TTTAGCGTCTGTTCTGCTTGT	0.393000													131	192					1.44193e-45	1.58714e-45	1	1	0
TTN	7273	broad.mit.edu	37	2	179482790	179482790	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:179482790A>T	ENST00000589042.1	-	253	47512	c.47288T>A	c.(47287-47289)tTg>tAg	p.L15763*	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.L13195*|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.L6698*|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.L14122*|TTN_ENST00000342175.6_Nonsense_Mutation_p.L6890*|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000359218.5_Nonsense_Mutation_p.L6823*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14122	Fibronectin type-III 14.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTTACATTCAAAGGAGGGCC	0.418000													37	38					0	0	1	0	0
MMD2	221938	broad.mit.edu	37	7	4955703	4955703	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:4955703C>A	ENST00000404774.3	-	4	492	c.298G>T	c.(298-300)Gaa>Taa	p.E100*	MMD2_ENST00000406755.1_Nonsense_Mutation_p.E100*|MMD2_ENST00000401401.3_Nonsense_Mutation_p.E100*	NM_001100600.1	NP_001094070.1	Q8IY49	PAQRA_HUMAN	monocyte to macrophage differentiation-associated 2	100						integral to membrane	receptor activity	p.E100K(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(11)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		AGACAGTGTTCCACCATCCTA	0.622000													31	49					1.74807e-11	1.82171e-11	1	1	0
NDST4	64579	broad.mit.edu	37	4	115891668	115891668	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:115891668A>G	ENST00000264363.2	-	4	1817	c.1139T>C	c.(1138-1140)aTg>aCg	p.M380T		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	380	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GTGGCTCCACATGTGAGGAAA	0.418000													22	24					0	0	1	0	0
TPP2	7174	broad.mit.edu	37	13	103286387	103286387	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr13:103286387G>A	ENST00000376052.3	+	11	1348	c.1332G>A	c.(1330-1332)ctG>ctA	p.L444L	TPP2_ENST00000376065.4_Silent_p.L444L			P29144	TPP2_HUMAN	tripeptidyl peptidase II	444					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GGACGCAGCTGATGAATGGAA	0.502000													13	106					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39234255	39234255	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:39234255C>T	ENST00000426016.1	-	17	2676	c.2590G>A	c.(2590-2592)Gag>Aag	p.E864K	SOS1_ENST00000402219.2_Missense_Mutation_p.E864K|SOS1_ENST00000395038.2_Missense_Mutation_p.E864K			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	864	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				TTGTTCAACTCTTGAAAGACT	0.358000									Noonan syndrome				72	60					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173782571	173782571	+	Silent	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:173782571T>C	ENST00000264111.6	+	5	673	c.486T>C	c.(484-486)taT>taC	p.Y162Y	RAPGEF4_ENST00000409036.1_Silent_p.Y162Y|RAPGEF4_ENST00000538974.1_Silent_p.Y9Y|RAPGEF4_ENST00000397087.3_Silent_p.Y18Y|RAPGEF4_ENST00000397081.3_Silent_p.Y162Y|RAPGEF4_ENST00000473043.1_3'UTR|RAPGEF4_ENST00000539331.1_Silent_p.Y9Y|RAPGEF4_ENST00000540783.1_Silent_p.Y9Y			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	162					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CTCCTCCTTATGGTGTTATGG	0.358000													67	75					0	0	1	0	0
ZFAND2B	130617	broad.mit.edu	37	2	220073293	220073293	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:220073293G>C	ENST00000409097.1	+	7	730	c.673G>C	c.(673-675)Gag>Cag	p.E225Q	ZFAND2B_ENST00000289528.5_Splice_Site|ZFAND2B_ENST00000409217.1_Splice_Site|ZFAND2B_ENST00000409206.1_3'UTR|ZFAND2B_ENST00000409336.1_Splice_Site|ZFAND2B_ENST00000409594.1_3'UTR|ZFAND2B_ENST00000444522.2_Missense_Mutation_p.E225Q			Q8WV99	ZFN2B_HUMAN	zinc finger, AN1-type domain 2B	0						endoplasmic reticulum	protein binding|zinc ion binding			endometrium(2)|kidney(4)|lung(4)|upper_aerodigestive_tract(1)	11		Renal(207;0.0915)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCCTTTGTAGAGTGAGGATG	0.522000													58	75					0	0	1	0	0
CDC45	8318	broad.mit.edu	37	22	19470303	19470303	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr22:19470303G>C	ENST00000407835.1	+	5	551	c.295G>C	c.(295-297)Gac>Cac	p.D99H	CDC45_ENST00000263201.1_Missense_Mutation_p.D99H|CDC45_ENST00000404724.3_Intron|CDC45_ENST00000437685.2_Missense_Mutation_p.D99H|CDC45_ENST00000483431.1_3'UTR			O75419	CDC45_HUMAN	cell division cycle 45	99					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	19						CTTTGTGTGTGACACCCATAG	0.363000													98	92					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589142	140589142	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:140589142C>T	ENST00000239450.2	+	1	852	c.663C>T	c.(661-663)ccC>ccT	p.P221P	PCDHB12_ENST00000541609.1_Intron	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		221	Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTCCCCTCCCAGGTCTGGAA	0.502000													40	48					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	31351025	31351025	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:31351025C>T	ENST00000225823.2	-	6	2075	c.1203G>A	c.(1201-1203)ttG>ttA	p.L401L	ASIC2_ENST00000448983.1_5'UTR|ASIC2_ENST00000359872.6_Silent_p.L350L	NM_183377.1	NP_899233.1	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	350					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	CCTTTTCCGCCAACAGACCTG	0.532000													97	75					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													23	23					0	0	1	0	0
GPR162	27239	broad.mit.edu	37	12	6936107	6936107	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:6936107G>A	ENST00000311268.3	+	5	2292	c.1505G>A	c.(1504-1506)cGg>cAg	p.R502Q	GPR162_ENST00000382315.3_Missense_Mutation_p.R198Q|GPR162_ENST00000428545.2_Missense_Mutation_p.R218Q	NM_019858.1	NP_062832.1	Q16538	GP162_HUMAN	G protein-coupled receptor 162	502						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.R502P(1)		NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(1)	18						GGCTTCTTCCGGGAGGAGATC	0.657000													115	91					0	0	1	0	0
SFR1	119392	broad.mit.edu	37	10	105885385	105885385	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:105885385C>T	ENST00000336358.5	+	3	1366	c.847C>T	c.(847-849)Caa>Taa	p.Q283*	SFR1_ENST00000369727.3_Nonsense_Mutation_p.Q221*|SFR1_ENST00000369729.3_Nonsense_Mutation_p.Q208*			Q86XK3	SFR1_HUMAN	SWI5-dependent recombination repair 1	221					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding										AAGCCTTACTCAATTGATAGA	0.353000													32	40					0	0	1	0	0
PER3	8863	broad.mit.edu	37	1	7887870	7887870	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:7887870G>C	ENST00000377532.3	+	17	3105	c.2881G>C	c.(2881-2883)Gag>Cag	p.E961Q	PER3_ENST00000361923.2_Missense_Mutation_p.E953Q			P56645	PER3_HUMAN	period circadian clock 3	953					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CCCACAAACTGAGTATGTAAG	0.443000													21	52					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138414437	138414437	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:138414437G>C	ENST00000409968.1	+	23	4355	c.4177G>C	c.(4177-4179)Gag>Cag	p.E1393Q	THSD7B_ENST00000272643.3_Missense_Mutation_p.E1396Q|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.E1365Q					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AAGAAGCTTTGAGACTGTGGG	0.473000													36	47					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27503822	27503822	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:27503822C>T	ENST00000356183.4	-	19	3003	c.2988G>A	c.(2986-2988)ttG>ttA	p.L996L	GTF3C1_ENST00000561623.1_Silent_p.L996L	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	996						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CATTCTTCTTCAAGAAGATAA	0.517000													49	43					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110397820	110397820	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:110397820T>C	ENST00000378402.5	+	6	634	c.530T>C	c.(529-531)aTt>aCt	p.I177T		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	177	IPT/TIG 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGAAGTAATATTGCACTAAGC	0.294000										HNSCC(38;0.096)			32	29					0	0	1	0	0
PSMA4	5685	broad.mit.edu	37	15	78834986	78834986	+	Splice_Site	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:78834986G>T	ENST00000044462.7	+	4	358	c.208G>T	c.(208-210)Gag>Tag	p.E70*	PSMA4_ENST00000558341.1_Splice_Site_p.E70*|PSMA4_ENST00000558281.1_Splice_Site_p.E70*|PSMA4_ENST00000413382.2_Intron|PSMA4_ENST00000560217.1_Splice_Site_p.E39*|PSMA4_ENST00000557929.1_3'UTR|PSMA4_ENST00000559082.1_Splice_Site_p.E70*	NM_002789.4	NP_002780.1	P25789	PSA4_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 4	70					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity			kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9						TAAACTCAATGAGTAAGTGAG	0.358000													39	77					1.60099e-16	1.69474e-16	1	1	0
UBIAD1	29914	broad.mit.edu	37	1	11345735	11345735	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:11345735C>T	ENST00000376810.5	+	2	890	c.564C>T	c.(562-564)ctC>ctT	p.L188L	UBIAD1_ENST00000376804.2_Intron	NM_013319.2	NP_037451.1	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	188			L -> H (in SCCD).		menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		TGGGAGACCTCATCATCCTCA	0.557000													33	35					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117310613	117310613	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:117310613G>T	ENST00000321322.6	-	22	4083	c.4082C>A	c.(4081-4083)aCa>aAa	p.T1361K	DSCAML1_ENST00000527706.1_Missense_Mutation_p.T1091K	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1301	Ig-like C2-type 10.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CATCCAAGGTGTTGTCACGGT	0.572000													63	60					6.20203e-27	6.70105e-27	1	1	0
PRKAA2	5563	broad.mit.edu	37	1	57169957	57169957	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:57169957G>C	ENST00000371244.4	+	7	1168	c.1102G>C	c.(1102-1104)Gaa>Caa	p.E368Q		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	368					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						ACCTCATCCAGAAAGGATGCC	0.473000													24	71					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49598163	49598163	+	RNA	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:49598163G>T	ENST00000527477.1	+	0	767																											CTTCGGAAGAGGAAGAGGGCT	0.532000													9	21					1.15088e-07	1.18621e-07	1	1	0
PLEC	5339	broad.mit.edu	37	8	144997377	144997377	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:144997377C>T	ENST00000322810.4	-	31	7300	c.7131G>A	c.(7129-7131)ctG>ctA	p.L2377L	PLEC_ENST00000356346.3_Silent_p.L2226L|PLEC_ENST00000527096.1_Silent_p.L2263L|PLEC_ENST00000354589.3_Silent_p.L2240L|PLEC_ENST00000354958.2_Silent_p.L2218L|PLEC_ENST00000436759.2_Silent_p.L2267L|PLEC_ENST00000398774.2_Silent_p.L2208L|PLEC_ENST00000357649.2_Silent_p.L2244L|PLEC_ENST00000345136.3_Silent_p.L2240L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2377	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						TGAGCTTGCTCAGCTCCTCCA	0.637000													19	18					0	0	1	0	0
C1orf110	339512	broad.mit.edu	37	1	162824960	162824960	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:162824960G>A	ENST00000367912.2	-	4	675	c.501C>T	c.(499-501)gaC>gaT	p.D167D	C1orf110_ENST00000367910.1_Silent_p.D168D|C1orf110_ENST00000367911.2_Silent_p.D163D|C1orf110_ENST00000524691.1_Intron			Q86UF4	CA110_HUMAN	chromosome 1 open reading frame 110											endometrium(2)|kidney(1)|lung(6)|prostate(1)|skin(2)	12						TGGGGTCTACGTCCTTAGATG	0.463000													263	86					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262271	45262271	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:45262271C>A	ENST00000303230.4	-	8	2482	c.2425G>T	c.(2425-2427)Ggc>Tgc	p.G809C		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	809						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						AGGGACTCGCCCACAGTGGGA	0.667000													45	33					4.16155e-14	4.37567e-14	1	1	0
ZNF665	79788	broad.mit.edu	37	19	53668485	53668485	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:53668485G>C	ENST00000600412.1	-	2	1178	c.1063C>G	c.(1063-1065)Cat>Gat	p.H355D	ZNF665_ENST00000396424.3_Missense_Mutation_p.H420D			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		ATTCTTCGATGATTTGCTAAG	0.403000													25	62					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56649313	56649313	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:56649313G>C	ENST00000389934.3	-	25	3923	c.3806C>G	c.(3805-3807)tCt>tGt	p.S1269C	TEX14_ENST00000349033.5_Missense_Mutation_p.S1229C|TEX14_ENST00000240361.8_Missense_Mutation_p.S1275C	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	1275						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGAGTTTCAGAGGAAGTAAG	0.443000													81	58					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12957694	12957694	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:12957694C>T	ENST00000276297.4	-	9	2561	c.2152G>A	c.(2152-2154)Gcc>Acc	p.A718T	DLC1_ENST00000358919.2_Missense_Mutation_p.A281T|DLC1_ENST00000520226.1_Missense_Mutation_p.A207T|DLC1_ENST00000512044.2_Missense_Mutation_p.A315T	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	718					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CCATTGAGGGCGGAGATCTCC	0.587000													49	38					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138664663	138664663	+	Splice_Site	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chrX:138664663C>G	ENST00000520602.1	-	28	3211		c.e28-1		MCF2_ENST00000414978.1_Splice_Site|MCF2_ENST00000370573.4_Splice_Site|MCF2_ENST00000370578.4_Splice_Site|MCF2_ENST00000536274.1_Splice_Site|MCF2_ENST00000338585.6_Splice_Site|MCF2_ENST00000370576.4_Splice_Site|MCF2_ENST00000519895.1_Splice_Site			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					ACACAGGTCTCTACAAGGGAA	0.453000													18	1					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34241294	34241294	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr20:34241294C>G	ENST00000374114.3	-	3	2214	c.1951G>C	c.(1951-1953)Gga>Cga	p.G651R	RP1-309K20.6_ENST00000541176.2_Intron|CPNE1_ENST00000397446.1_Intron|CPNE1_ENST00000397445.1_Intron|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000352393.4_Intron|CPNE1_ENST00000317677.5_Intron|CPNE1_ENST00000397442.1_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.G651R|RBM12_ENST00000359646.1_Missense_Mutation_p.G651R|CPNE1_ENST00000397443.1_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	651	Gly-rich.|Pro-rich.					nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			TTGGGCATTCCTGGAACTGCA	0.542000													81	35					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736327	140736327	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:140736327C>T	ENST00000571252.1	+	1	1560	c.1560C>T	c.(1558-1560)ttC>ttT	p.F520F	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTGCTCCTTCGACTATGAGC	0.527000													101	112					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202294	56202294	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr18:56202294C>G	ENST00000361673.3	-	5	5338	c.5125G>C	c.(5125-5127)Gag>Cag	p.E1709Q		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1709							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TTGACCTCCTCTGACCCCGTC	0.572000													52	56					0	0	1	0	0
PHF11	51131	broad.mit.edu	37	13	50087246	50087246	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr13:50087246G>C	ENST00000357596.3	+	4	427	c.151G>C	c.(151-153)Gat>Cat	p.D51H	PHF11_ENST00000378319.3_Missense_Mutation_p.D90H|PHF11_ENST00000488958.1_Missense_Mutation_p.D51H	NM_001040444.1	NP_001035534.1	Q9UIL8	PHF11_HUMAN	PHD finger protein 11	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			large_intestine(3)|lung(1)	4		Lung NSC(96;2.1e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.38e-09)		ACTTAATCCTGATAGAAGTTT	0.363000													11	50					0	0	1	0	0
BASP1	10409	broad.mit.edu	37	5	17275493	17275493	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:17275493G>A	ENST00000322611.3	+	2	428	c.168G>A	c.(166-168)gaG>gaA	p.E56E		NM_001271606.1|NM_006317.3	NP_001258535.1|NP_006308.3	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein 1	56					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding			endometrium(1)|lung(8)	9						AGGGCAAGGAGAAGCCCGACC	0.716000													9	10					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803672	142803672	+	RNA	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:142803672G>T	ENST00000423385.1	-	0	1293																											tatgttctatgcatttatcat	0.308000													3	33					0.00909568	0.00913455	1	1	0
CYP2C8	1558	broad.mit.edu	37	10	96802798	96802798	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:96802798C>T	ENST00000371270.3	-	7	1092	c.998G>A	c.(997-999)aGa>aAa	p.R333K	CYP2C8_ENST00000539050.1_Missense_Mutation_p.R247K|CYP2C8_ENST00000535898.1_Missense_Mutation_p.R231K	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	333					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	GCTCCTGTGTCTGCCAATTAC	0.468000													48	55					0	0	1	0	0
SLC9A1	6548	broad.mit.edu	37	1	27427035	27427035	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:27427035C>T	ENST00000263980.3	-	12	2786	c.2211G>A	c.(2209-2211)ctG>ctA	p.L737L	SLC9A1_ENST00000545949.1_Silent_p.L398L	NM_003047.4	NP_003038.2	P19634	SL9A1_HUMAN	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	737					regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	CTTTGCCCTTCAGCTCTTCAT	0.597000													143	190					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128742	45128742	+	RNA	SNP	T	T	G	rs34655963	by1000genomes	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:45128742T>G	ENST00000575173.1	-	0	418																											TAATGATTTTTATTATACTTT	0.328000													4	39					0	0	1	0	0
FBXO44	93611	broad.mit.edu	37	1	11718647	11718647	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:11718647G>A	ENST00000376768.1	+	4	523	c.421G>A	c.(421-423)Gat>Aat	p.D141N	FBXO44_ENST00000251546.4_Intron|FBXO44_ENST00000251547.5_Silent_p.L150L|FBXO44_ENST00000376762.4_Intron|FBXO44_ENST00000376770.1_Silent_p.L150L|FBXO44_ENST00000376760.1_Intron			Q9H4M3	FBX44_HUMAN	F-box protein 44	0	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	8	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		GGGAGGAGCTGATGGATACCA	0.672000													36	34					0	0	1	0	0
CUTA	51596	broad.mit.edu	37	6	33385041	33385041	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:33385041G>C	ENST00000374500.5	-	3	492	c.361C>G	c.(361-363)Cag>Gag	p.Q121E	CUTA_ENST00000488478.1_Missense_Mutation_p.Q102E|CUTA_ENST00000374496.3_Missense_Mutation_p.Q79E|CUTA_ENST00000488034.1_Missense_Mutation_p.Q102E|CUTA_ENST00000494751.1_Missense_Mutation_p.Q79E|CUTA_ENST00000607266.1_Missense_Mutation_p.Q79E|CUTA_ENST00000440279.3_Missense_Mutation_p.Q79E	NM_001014433.2	NP_001014433.1	O60888	CUTA_HUMAN	cutA divalent cation tolerance homolog (E. coli)	102					protein localization|response to metal ion	membrane	enzyme binding		SLC22A1/CUTA(2)	kidney(1)|lung(3)|urinary_tract(1)	5						GATGTAATCTGAGGGATGAGG	0.527000													18	50					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59857658	59857658	+	Missense_Mutation	SNP	G	G	C	rs28997572		TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:59857658G>C	ENST00000259008.2	-	13	2166	c.1899C>G	c.(1897-1899)atC>atG	p.I633M	BRIP1_ENST00000577598.1_Missense_Mutation_p.I633M	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	633			I -> M (in dbSNP:rs28997572).		DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						CCTCCAGCTGGATAGTAAATG	0.328000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					31	79					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19662607	19662607	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr20:19662607C>T	ENST00000328041.6	+	10	1070	c.873C>T	c.(871-873)tgC>tgT	p.C291C		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	291						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GCAGCAACTGCGACGCAACTG	0.512000													34	76					0	0	1	0	0
CD200	4345	broad.mit.edu	37	3	112064109	112064109	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:112064109C>T	ENST00000315711.8	+	3	452	c.395C>T	c.(394-396)tCa>tTa	p.S132L	CD200_ENST00000473539.1_Missense_Mutation_p.S157L|CD200_ENST00000383681.3_Missense_Mutation_p.S58L	NM_005944.5	NP_005935.4	P41217	OX2G_HUMAN	CD200 molecule	132	Ig-like V-type.				regulation of immune response	integral to plasma membrane				endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				GGGAAGATCTCAGGAACGGCC	0.448000													29	63					0	0	1	0	0
LCMT2	9836	broad.mit.edu	37	15	43622106	43622106	+	Silent	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:43622106G>C	ENST00000305641.5	-	1	697	c.582C>G	c.(580-582)ctC>ctG	p.L194L	LCMT2_ENST00000567039.1_Intron|LCMT2_ENST00000544735.1_Intron	NM_014793.4	NP_055608.2	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	194					tRNA processing		methyltransferase activity|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|liver(1)|lung(9)|skin(1)|urinary_tract(1)	20		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	TCTCCGGCTCGAGGTAGGTCA	0.667000													19	88					0	0	1	0	0
KARS	3735	broad.mit.edu	37	16	75669580	75669580	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:75669580C>T	ENST00000319410.5	-	7	998	c.877G>A	c.(877-879)Gag>Aag	p.E293K	KARS_ENST00000302445.3_Missense_Mutation_p.E265K|KARS_ENST00000568378.1_Intron	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	265					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	CTCCTTACCTCTAGGAATCCC	0.458000													24	30					0	0	1	0	0
KRT12	3859	broad.mit.edu	37	17	39021105	39021105	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:39021105C>T	ENST00000251643.4	-	3	783	c.760G>A	c.(760-762)Gag>Aag	p.E254K		NM_000223.3	NP_000214.1	Q99456	K1C12_HUMAN	keratin 12	254	Coil 1B.|Rod.				visual perception	intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	15		Breast(137;0.000301)				TTCAGGCTCTCGATCTGCATC	0.592000													78	155					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													4	65					0.150653	0.150653	1	1	0
KAT5	10524	broad.mit.edu	37	11	65481086	65481086	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:65481086C>T	ENST00000341318.4	+	5	797	c.563C>T	c.(562-564)tCa>tTa	p.S188L	KAT5_ENST00000352980.4_Missense_Mutation_p.S103L|KAT5_ENST00000534650.1_5'UTR|KAT5_ENST00000530446.1_Missense_Mutation_p.S136L|KAT5_ENST00000377046.3_Missense_Mutation_p.S155L|KAT5_ENST00000525204.1_3'UTR	NM_182710.2	NP_874369.1	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5	155					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)	21						GAGGTGGTTTCACCAGCAACT	0.532000													46	68					0	0	1	0	0
SCLY	51540	broad.mit.edu	37	2	238999898	238999898	+	Silent	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:238999898G>C	ENST00000409736.2	+	8	948	c.924G>C	c.(922-924)gtG>gtC	p.V308V	SCLY_ENST00000555827.1_Intron|SCLY_ENST00000254663.6_Intron|SCLY_ENST00000422984.2_Intron|SCLY_ENST00000429612.2_Intron|SCLY_ENST00000373332.3_Silent_p.V226V			Q96I15	SCLY_HUMAN	selenocysteine lyase	308					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	22		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		TTGGGAAGGTGAGCCCTGGTG	0.478000													57	100					0	0	1	0	0
HUNK	30811	broad.mit.edu	37	21	33371051	33371051	+	Missense_Mutation	SNP	C	C	T	rs141493785	by1000genomes	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr21:33371051C>T	ENST00000270112.2	+	11	2059	c.1699C>T	c.(1699-1701)Cgc>Tgc	p.R567C		NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	567					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						GTCTGTGGATCGCGACGACCA	0.602000													34	3					0	0	1	0	0
ZBTB46	140685	broad.mit.edu	37	20	62422018	62422018	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr20:62422018G>A	ENST00000245663.4	-	2	243	c.93C>T	c.(91-93)tgC>tgT	p.C31C	ZBTB46_ENST00000395104.1_Silent_p.C31C|ZBTB46_ENST00000302995.2_Silent_p.C31C	NM_025224.3	NP_079500.2	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	31	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CGCAGACGTCGCACAGGACGC	0.592000													11	109					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	51995063	51995063	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:51995063C>T	ENST00000291707.3	-	8	1675	c.1620G>A	c.(1618-1620)ccG>ccA	p.P540P	SIGLEC12_ENST00000598614.1_Silent_p.P422P	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	540					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TGTCATCTGCCGGGGATTCAA	0.617000													39	33					0	0	1	0	0
PACS1	55690	broad.mit.edu	37	11	66003405	66003405	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:66003405C>A	ENST00000320580.4	+	19	2277	c.2244C>A	c.(2242-2244)ttC>ttA	p.F748L	PACS1_ENST00000529757.1_Missense_Mutation_p.F284L	NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	748					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						TTATTCCCTTCATTGGCGTGA	0.498000													16	144					3.45872e-05	3.52624e-05	1	1	0
FBXW7	55294	broad.mit.edu	37	4	153273676	153273676	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:153273676C>T	ENST00000263981.5	-	1	447	c.207G>A	c.(205-207)ggG>ggA	p.G69G	FBXW7_ENST00000603548.1_Intron|FBXW7_ENST00000281708.4_Intron|FBXW7_ENST00000296555.5_Intron|FBXW7_ENST00000603841.1_Intron	NM_018315.4	NP_060785.2	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	0					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding			NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CTGTATTTTTCCCCTTCAGTG	0.393000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								28	41					0	0	1	0	0
SF3B4	10262	broad.mit.edu	37	1	149895601	149895601	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:149895601G>A	ENST00000271628.8	-	6	1692	c.1108C>T	c.(1108-1110)Ccg>Tcg	p.P370S		NM_005850.4	NP_005841.1	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4, 49kDa	370						nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			endometrium(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)	17	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			ATACCATGCGGAGGCATAGGA	0.577000													33	10					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21830970	21830970	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:21830970G>A	ENST00000216297.2	-	14	1986	c.1648C>T	c.(1648-1650)Cac>Tac	p.H550Y		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	550					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		GTGGCAATGTGAAACGGTGTT	0.373000													79	83					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106888480	106888480	+	Splice_Site	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:106888480G>C	ENST00000526355.2	-	1	770	c.302C>G	c.(301-303)tCg>tGg	p.S101W	GUCY1A2_ENST00000347596.2_Splice_Site_p.S101W|GUCY1A2_ENST00000282249.2_Splice_Site_p.S101W	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2						intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		CCCGCTCACCGAGGGCGCCGT	0.756000													14	10					0	0	1	0	0
SLC22A11	55867	broad.mit.edu	37	11	64335224	64335224	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:64335224C>G	ENST00000301891.4	+	7	1586	c.1212C>G	c.(1210-1212)atC>atG	p.I404M	SLC22A11_ENST00000377585.3_Intron|SLC22A11_ENST00000377581.3_Missense_Mutation_p.I404M	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	404					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	GCCGCACCATCCAGGCGGGTT	0.692000													23	26					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52547734	52547734	+	Splice_Site	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:52547734G>A	ENST00000321725.6	+	31	3348	c.3272G>A	c.(3271-3273)aGg>aAg	p.R1091K		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1091	FAS1 3.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCCTTCCAGAGGGTCTGGGTG	0.607000													5	38					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10415816	10415816	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:10415816G>A	ENST00000226207.5	-	12	1150	c.1056C>T	c.(1054-1056)atC>atT	p.I352I	CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA|RP11-799N11.1_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	352	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TGAGCTTATAGATGGACACTC	0.433000													49	2					0	0	1	0	0
CMTM6	54918	broad.mit.edu	37	3	32533338	32533338	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:32533338G>A	ENST00000205636.3	-	2	841	c.179C>T	c.(178-180)tCa>tTa	p.S60L		NM_017801.2	NP_060271.1	Q9NX76	CKLF6_HUMAN	CKLF-like MARVEL transmembrane domain containing 6	60	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			breast(1)|endometrium(1)	2						AGTACATTGTGATACAACTTC	0.353000													11	29					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	77					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110460573	110460573	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:110460573T>C	ENST00000378402.5	+	39	6082	c.5978T>C	c.(5977-5979)gTt>gCt	p.V1993A		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1993	IPT/TIG 12.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATGTCCACAGTTGTATTTGAG	0.408000										HNSCC(38;0.096)			15	15					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44945115	44945115	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chrX:44945115C>T	ENST00000377967.4	+	24	3480	c.3439C>T	c.(3439-3441)Cag>Tag	p.Q1147*	KDM6A_ENST00000543216.1_Nonsense_Mutation_p.Q1068*|KDM6A_ENST00000536777.1_Nonsense_Mutation_p.Q1102*|KDM6A_ENST00000382899.4_Nonsense_Mutation_p.Q1154*	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	1147	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TTCAGGTCATCAGGAAAATAA	0.363000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								30	1					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710881	140710881	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:140710881C>T	ENST00000517417.1	+	1	630	c.630C>T	c.(628-630)ctC>ctT	p.L210L	PCDHGA1_ENST00000378105.3_Silent_p.L210L	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCACCACCTCATCCTCACAG	0.517000													30	47					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50780089	50780089	+	Silent	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:50780089G>T	ENST00000404971.1	-	10	2854	c.1515C>A	c.(1513-1515)atC>atA	p.I505I	NRXN1_ENST00000401669.2_Silent_p.I465I|NRXN1_ENST00000406316.2_Silent_p.I465I|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000402717.3_Silent_p.I457I|NRXN1_ENST00000405472.3_Silent_p.I457I|NRXN1_ENST00000406859.3_Silent_p.I465I	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	465	Laminin G-like 3.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCACTCCATGGATCTTCATCT	0.413000													68	77					2.32099e-22	2.49056e-22	1	1	0
HTT	3064	broad.mit.edu	37	4	3237102	3237102	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:3237102G>C	ENST00000355072.5	+	62	8693	c.8548G>C	c.(8548-8550)Gaa>Caa	p.E2850Q	HTT_ENST00000513806.1_3'UTR	NM_002111.6	NP_002102	P42858	HD_HUMAN	huntingtin	2850					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CGTAGGGCCGGAATTTTCAGC	0.522000													12	41					0	0	1	0	0
KIF23	9493	broad.mit.edu	37	15	69732772	69732772	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:69732772G>A	ENST00000260363.4	+	17	2130	c.2013G>A	c.(2011-2013)cgG>cgA	p.R671R	KIF23_ENST00000352331.4_Silent_p.R671R|KIF23_ENST00000537891.1_Silent_p.R488R|KIF23_ENST00000395392.2_Silent_p.R671R|KIF23_ENST00000559279.1_Silent_p.R671R|KIF23_ENST00000558585.1_Silent_p.R488R	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	671					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						GACCCTCTCGGGAGCGAGATC	0.393000													57	47					0	0	1	0	0
MAP7D3	79649	broad.mit.edu	37	X	135313900	135313900	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chrX:135313900C>T	ENST00000316077.9	-	8	1436	c.1216G>A	c.(1216-1218)Gtg>Atg	p.V406M	MAP7D3_ENST00000370663.5_Missense_Mutation_p.V388M|MAP7D3_ENST00000370661.1_Missense_Mutation_p.V371M	NM_024597.3	NP_078873.2	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	406						cytoplasm|spindle				central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(1)	44	Acute lymphoblastic leukemia(192;0.000127)					GCTGCTTCCACGCTCACCTCT	0.617000													94	1					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99772407	99772407	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:99772407C>T	ENST00000370185.3	+	7	2630	c.2133C>T	c.(2131-2133)agC>agT	p.S711S	LPPR4_ENST00000457765.1_Silent_p.S653S|LPPR4_ENST00000370184.1_Silent_p.S553S	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		711							phosphatidate phosphatase activity	p.S711R(2)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TAGAGGGCAGCGAAATTGGCT	0.522000													27	24					0	0	1	0	0
ITGA1	3672	broad.mit.edu	37	5	52194074	52194074	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:52194074G>A	ENST00000282588.6	+	11	1628	c.1170G>A	c.(1168-1170)tgG>tgA	p.W390*		NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	390					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GTAAGGACTGGGTCATGCTTG	0.338000													6	6					0	0	1	0	0
SFXN2	118980	broad.mit.edu	37	10	104492632	104492632	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:104492632C>T	ENST00000369893.5	+	9	905	c.738C>T	c.(736-738)atC>atT	p.I246I		NM_178858.4	NP_849189.1	Q96NB2	SFXN2_HUMAN	sideroflexin 2						iron ion homeostasis	integral to membrane	cation transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|prostate(1)	13		Colorectal(252;0.207)		Epithelial(162;4.53e-09)|all cancers(201;1.2e-07)|BRCA - Breast invasive adenocarcinoma(275;0.218)		TGCCAGTCATCATGGAAAGGC	0.547000													33	34					0	0	1	0	0
WISP2	8839	broad.mit.edu	37	20	43348661	43348661	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr20:43348661G>A	ENST00000372868.2	+	3	527	c.184G>A	c.(184-186)Gag>Aag	p.E62K	RP11-445H22.4_ENST00000445420.1_RNA|RP11-445H22.4_ENST00000427303.1_RNA|WISP2_ENST00000190983.4_Missense_Mutation_p.E62K|WISP2_ENST00000372865.4_Missense_Mutation_p.E62K|RP11-445H22.4_ENST00000427598.1_RNA			O76076	WISP2_HUMAN	WNT1 inducible signaling pathway protein 2	62	IGFBP N-terminal.				cell adhesion|cell-cell signaling|signal transduction	extracellular region|soluble fraction	insulin-like growth factor binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				GCGGCTGGGGGAGCCCTGCGA	0.716000													10	36					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67400992	67400992	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:67400992T>C	ENST00000329956.6	+	8	846	c.827T>C	c.(826-828)gTa>gCa	p.V276A	LRRC36_ENST00000563189.1_Missense_Mutation_p.V155A|LRRC36_ENST00000541146.1_Intron|LRRC36_ENST00000290940.7_Missense_Mutation_p.V8A|LRRC36_ENST00000435835.3_Missense_Mutation_p.V155A	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	276										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		GGGTACCAAGTATCTTTTTTG	0.413000													70	51					0	0	1	0	0
CDT1	81620	broad.mit.edu	37	16	88871854	88871854	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:88871854G>A	ENST00000301019.4	+	4	1114	c.495G>A	c.(493-495)gaG>gaA	p.E165E		NM_030928.3	NP_112190.2	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor 1	165	Interaction with GMNN.				DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(3)	7				BRCA - Breast invasive adenocarcinoma(80;0.0476)		ACAGTGGCGAGAAGGCGCCCG	0.687000													23	61					0	0	1	0	0
AIFM3	150209	broad.mit.edu	37	22	21327646	21327646	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr22:21327646G>A	ENST00000399167.2	+	3	322	c.82G>A	c.(82-84)Gag>Aag	p.E28K	AIFM3_ENST00000333607.6_Missense_Mutation_p.E28K|AIFM3_ENST00000399163.2_Missense_Mutation_p.E28K|AIFM3_ENST00000335375.5_Silent_p.R52R|AIFM3_ENST00000440238.2_Missense_Mutation_p.E28K|AIFM3_ENST00000405089.1_Missense_Mutation_p.E34K	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3									p.E28K(1)		breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			AGGCAAGGAGGAGCTGTCGGC	0.677000													10	14					0	0	1	0	0
PER3	8863	broad.mit.edu	37	1	7880243	7880243	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:7880243C>T	ENST00000377532.3	+	14	1951	c.1727C>T	c.(1726-1728)tCc>tTc	p.S576F	RP3-467L1.4_ENST00000451646.1_RNA|PER3_ENST00000361923.2_Missense_Mutation_p.S568F			P56645	PER3_HUMAN	period circadian clock 3	568	CSNK1E binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		ACAACTTCTTCCTCCTCAGAA	0.383000													34	24					0	0	1	0	0
MARCH8	220972	broad.mit.edu	37	10	45956740	45956740	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:45956740C>T	ENST00000453424.2	-	6	1469	c.1208G>A	c.(1207-1209)cGc>cAc	p.R403H	MARCH8_ENST00000319836.3_Missense_Mutation_p.R121H|MARCH8_ENST00000395771.3_Missense_Mutation_p.R121H|MARCH8_ENST00000476962.1_5'UTR|MARCH8_ENST00000395769.2_Missense_Mutation_p.R121H	NM_001282866.1	NP_001269795.1	Q5T0T0	MARH8_HUMAN	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	121						cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	12						CTCGCAGCAGCGCGTGTCGGA	0.577000													35	37					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102483642	102483642	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:102483642G>A	ENST00000321521.9	+	7	1223	c.650G>A	c.(649-651)aGt>aAt	p.S217N	PPIP5K2_ENST00000358359.3_Missense_Mutation_p.S217N|PPIP5K2_ENST00000414217.1_Missense_Mutation_p.S217N|PPIP5K2_ENST00000513500.1_3'UTR			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	217					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CAGATTGGCAGTAGAAGTAGT	0.313000													42	43					0	0	1	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186934581	186934581	+	Silent	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:186934581C>G	ENST00000367466.3	+	15	1772	c.1620C>G	c.(1618-1620)gtC>gtG	p.V540V	PLA2G4A_ENST00000442353.2_Silent_p.V480V	NM_024420.2	NP_077734	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	540	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	CTCTGGATGTCAAAAGTAAAA	0.358000													16	59					0	0	1	0	0
LANCL1	10314	broad.mit.edu	37	2	211306127	211306127	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:211306127C>A	ENST00000443314.1	-	4	790	c.448G>T	c.(448-450)Gaa>Taa	p.E150*	AC007970.1_ENST00000420418.1_RNA|AC007970.1_ENST00000433296.1_RNA|LANCL1_ENST00000431941.2_Nonsense_Mutation_p.E150*|LANCL1_ENST00000450366.2_Nonsense_Mutation_p.E150*|LANCL1_ENST00000441020.3_Nonsense_Mutation_p.E150*|LANCL1_ENST00000233714.4_Nonsense_Mutation_p.E150*			O43813	LANC1_HUMAN	LanC lantibiotic synthetase component C-like 1 (bacterial)	150						cytoplasm|integral to plasma membrane|microtubule cytoskeleton|nucleus	catalytic activity|G-protein coupled receptor activity|glutathione binding|low-density lipoprotein particle receptor binding|SH3 domain binding|zinc ion binding			breast(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12				Epithelial(149;0.00562)|Lung(261;0.0468)|LUSC - Lung squamous cell carcinoma(261;0.0495)|all cancers(144;0.0569)		TAGAGCATTTCATTTGGAGCA	0.363000													70	69					2.23399e-28	2.4305e-28	1	1	0
FNDC7	163479	broad.mit.edu	37	1	109268501	109268501	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:109268501A>T	ENST00000370017.3	+	6	1263	c.986A>T	c.(985-987)cAc>cTc	p.H329L	FNDC7_ENST00000271311.2_Missense_Mutation_p.H330L	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	330	Fibronectin type-III 4.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		TTGGAAGTACACTGCAACACA	0.453000													95	104					0	0	1	0	0
ADD1	118	broad.mit.edu	37	4	2899988	2899988	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:2899988C>G	ENST00000355842.3	+	8	1682	c.819C>G	c.(817-819)taC>taG	p.Y273*	ADD1_ENST00000503455.2_Nonsense_Mutation_p.Y273*|ADD1_ENST00000264758.7_Nonsense_Mutation_p.Y273*|ADD1_ENST00000398123.2_Nonsense_Mutation_p.Y273*|ADD1_ENST00000398129.1_Nonsense_Mutation_p.Y273*|ADD1_ENST00000398125.1_Nonsense_Mutation_p.Y273*|ADD1_ENST00000513328.2_Nonsense_Mutation_p.Y273*|ADD1_ENST00000446856.1_Nonsense_Mutation_p.Y273*			P35611	ADDA_HUMAN	adducin 1 (alpha)	273					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ATCATGACTACCATGGCATTC	0.448000													56	66					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26592073	26592073	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:26592073C>T	ENST00000381340.3	-	47	7046	c.6630G>A	c.(6628-6630)caG>caA	p.Q2210Q		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2210					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					TGATTTTCTTCTGCCACTTCA	0.368000													25	42					0	0	1	0	0
KIF14	9928	broad.mit.edu	37	1	200534684	200534684	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:200534684C>T	ENST00000367350.4	-	24	4213	c.3775G>A	c.(3775-3777)Gaa>Aaa	p.E1259K		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	1259	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						GTTCTTTCTTCATCATAACTC	0.333000													7	46					0	0	1	0	0
FSIP1	161835	broad.mit.edu	37	15	39910416	39910416	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:39910416G>A	ENST00000350221.3	-	11	1428	c.1219C>T	c.(1219-1221)Cag>Tag	p.Q407*		NM_152597.4	NP_689810.3	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	407										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	23		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		CACTTTAACTGTTCTTCAGAG	0.348000													31	84					0	0	1	0	0
S100A7A	338324	broad.mit.edu	37	1	153391682	153391682	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:153391682A>G	ENST00000368729.4	+	3	260	c.203A>G	c.(202-204)aAg>aGg	p.K68R	S100A7A_ENST00000329256.2_Missense_Mutation_p.K68R|S100A7A_ENST00000368728.2_Missense_Mutation_p.K68R	NM_176823.3	NP_789793.1	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7A	68	EF-hand 2.					cytoplasm	calcium ion binding			cervix(1)|endometrium(3)|kidney(1)|lung(3)|prostate(1)|skin(2)|stomach(1)	12	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AATGAGGATAAGAAGATTGAT	0.448000													62	17					0	0	1	0	0
RFWD3	55159	broad.mit.edu	37	16	74685892	74685892	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:74685892G>C	ENST00000361070.4	-	3	744	c.647C>G	c.(646-648)tCt>tGt	p.S216C	RFWD3_ENST00000571750.1_Missense_Mutation_p.S216C	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	216					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						GTCACTGTCAGAATCAGAACT	0.483000													79	43					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	592637	592637	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:592637G>A	ENST00000264555.5	+	6	711	c.583G>A	c.(583-585)Gag>Aag	p.E195K	PHRF1_ENST00000533464.1_Missense_Mutation_p.E191K|PHRF1_ENST00000416188.2_Missense_Mutation_p.E195K|PHRF1_ENST00000413872.2_Missense_Mutation_p.E194K	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	195							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						GAGCGACCGTGAGGACAGGCT	0.647000													76	94					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36341295	36341295	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:36341295C>G	ENST00000378910.5	-	5	578	c.579G>C	c.(577-579)caG>caC	p.Q193H	NPHS1_ENST00000353632.6_Missense_Mutation_p.Q193H	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	193	Ig-like C2-type 2.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGAAGAGTTTCTGCTGGGAGC	0.562000													28	59					0	0	1	0	0
BICD1	636	broad.mit.edu	37	12	32369352	32369352	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:32369352G>A	ENST00000548411.1	+	2	566	c.385G>A	c.(385-387)Gaa>Aaa	p.E129K	BICD1_ENST00000281474.5_Missense_Mutation_p.E129K	NM_001003398.1	NP_001003398.1	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	129					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			TGTACAGGCAGAAAACGAGAG	0.483000													34	24					0	0	1	0	0
H6PD	9563	broad.mit.edu	37	1	9324097	9324097	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:9324097C>T	ENST00000377403.2	+	5	1847	c.1545C>T	c.(1543-1545)ttC>ttT	p.F515F	H6PD_ENST00000602477.1_Silent_p.F526F	NM_001282587.1|NM_004285.3	NP_001269516.1|NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	515	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	ACTTTGAGTTCAGTAGCGGCC	0.637000													56	174					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6091021	6091021	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:6091021G>A	ENST00000261405.5	-	42	7472	c.7218C>T	c.(7216-7218)ccC>ccT	p.P2406P		NM_000552.3	NP_000543	P04275	VWF_HUMAN	von Willebrand factor	2406					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	AGTACCCAAGGGGACAGCTCA	0.557000													61	51					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119419747	119419747	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:119419747C>T	ENST00000267260.4	+	1	448	c.60C>T	c.(58-60)ttC>ttT	p.F20F		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	20					cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						GAGGAACCTTCAAAGCGGTGG	0.612000													6	18					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236437	140236437	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:140236437G>A	ENST00000307360.5	+	1	804	c.804G>A	c.(802-804)tcG>tcA	p.S268S	PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000506939.2_Silent_p.S268S|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018901.2	NP_061724.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCTGATTCGGATGAAGGAA	0.378000													47	63					0	0	1	0	0
CDCA7	83879	broad.mit.edu	37	2	174231117	174231117	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:174231117G>A	ENST00000306721.3	+	8	1245	c.1142G>A	c.(1141-1143)cGa>cAa	p.R381Q	CDCA7_ENST00000347703.3_Missense_Mutation_p.R302Q|CDCA7_ENST00000410019.3_Missense_Mutation_p.R260Q|CDCA7_ENST00000410101.3_Missense_Mutation_p.R337Q|CDCA7_ENST00000392567.2_Intron	NM_031942.4	NP_114148.3	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7	302					regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.116)			CCCTGCCTTCGAAACCGTTAT	0.542000													66	85					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100087420	100087420	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr9:100087420G>A	ENST00000395220.1	+	27	2890	c.1955G>A	c.(1954-1956)tGg>tAg	p.W652*	CCDC180_ENST00000529487.1_Silent_p.L541L|CCDC180_ENST00000411667.2_Silent_p.L538L|RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000357054.1_Silent_p.L680L|CCDC180_ENST00000460482.2_3'UTR|CCDC180_ENST00000375202.2_Silent_p.L541L					coiled-coil domain containing 180																		TGCAGGAGCTGGAGCTGGAGA	0.572000													11	0					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039230	11039230	+	RNA	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr21:11039230T>C	ENST00000470054.1	-	0	973									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTCTTTGGATACCACTGTTT	0.408000													43	226					0	0	1	0	0
C15orf52	388115	broad.mit.edu	37	15	40633063	40633063	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:40633063G>A	ENST00000559313.1	-	1	105	c.90C>T	c.(88-90)ctC>ctT	p.L30L	C15orf52_ENST00000557973.1_5'UTR	NM_207380.2	NP_997263.2	Q6ZUT6	CO052_HUMAN	chromosome 15 open reading frame 52	30										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	19		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		AGCCCCTGGGGAGCCAGAGTG	0.647000													9	25					0	0	1	0	0
COMTD1	118881	broad.mit.edu	37	10	76995480	76995480	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:76995480C>G	ENST00000372538.3	-	2	198	c.116G>C	c.(115-117)cGa>cCa	p.R39P	COMTD1_ENST00000460899.1_5'UTR	NM_144589.2	NP_653190.2	Q86VU5	CMTD1_HUMAN	catechol-O-methyltransferase domain containing 1	39						integral to membrane	O-methyltransferase activity			central_nervous_system(1)|large_intestine(1)|lung(1)	3	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)					TCGCCGGCCTCGCCATGGGGG	0.721000													7	10					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64122797	64122797	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:64122797C>T	ENST00000356786.5	+	25	4275	c.4231C>T	c.(4231-4233)Cct>Tct	p.P1411S	CCDC88B_ENST00000359902.2_Silent_p.A515A|CCDC88B_ENST00000301897.4_Missense_Mutation_p.P74S|CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	1411					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GTCATTCAGCCCTGGGGACAC	0.657000											OREG0021052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	9					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr20:29625934C>T	ENST00000278882.3	+	5	558	c.178C>T	c.(178-180)Cat>Tat	p.H60Y	FRG1B_ENST00000358464.4_Missense_Mutation_p.H60Y|FRG1B_ENST00000439954.2_Missense_Mutation_p.H65Y																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACTTGTTGGGCATTCAGATGC	0.338000													5	172					0	0	1	0	0
TRAV26-1	28657	broad.mit.edu	37	14	22591480	22591480	+	RNA	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:22591480G>A	ENST00000390455.3	+	0	205																											ATTTGTCCTTGAAGTATGAGG	0.463000													19	17					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34241363	34241363	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr20:34241363C>G	ENST00000374114.3	-	3	2145	c.1882G>C	c.(1882-1884)Gag>Cag	p.E628Q	RP1-309K20.6_ENST00000541176.2_Intron|CPNE1_ENST00000397446.1_Intron|CPNE1_ENST00000397445.1_Intron|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000352393.4_Intron|CPNE1_ENST00000317677.5_Intron|CPNE1_ENST00000397442.1_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.E628Q|RBM12_ENST00000359646.1_Missense_Mutation_p.E628Q|CPNE1_ENST00000397443.1_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	628						nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GGATTTTTCTCAATCTCTCTC	0.463000													129	63					0	0	1	0	0
KIAA0101	9768	broad.mit.edu	37	15	64668995	64668995	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:64668995C>T	ENST00000300035.4	-	3	375	c.237G>A	c.(235-237)gaG>gaA	p.E79E	KIAA0101_ENST00000380258.2_Intron|KIAA0101_ENST00000559519.1_Silent_p.E52E|KIAA0101_ENST00000558008.1_Silent_p.E79E	NM_014736.4	NP_055551.1	Q15004	PAF_HUMAN	KIAA0101	79			E -> K (in dbSNP:rs11554313).			mitochondrion|nucleus				central_nervous_system(1)|lung(1)|upper_aerodigestive_tract(1)	3						GAATCTGATTCTCTTTTTCAG	0.408000													36	23					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58076269	58076269	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:58076269C>G	ENST00000219271.3	+	7	2084	c.1299C>G	c.(1297-1299)ttC>ttG	p.F433L		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	433	Hemopexin-like 2.				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						TTGTCTTTTTCAAAGGTGAGC	0.572000													17	80					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49805527	49805527	+	RNA	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:49805527C>T	ENST00000527477.1	+	0	1215																											GCCCAAGGCCCGGGTGGTGGC	0.547000													28	22					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34103188	34103188	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:34103188G>C	ENST00000389232.4	+	72	10277	c.10207G>C	c.(10207-10209)Gat>Cat	p.D3403H	RYR3_ENST00000415757.3_Missense_Mutation_p.D3398H	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3403					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAGGGACACAGATGAAGAGGT	0.483000													8	21					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212798591	212798591	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:212798591G>A	ENST00000294829.3	+	1	803	c.372G>A	c.(370-372)ctG>ctA	p.L124L	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	124										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		TTCTGCCCCTGAGGTTTGTAC	0.537000													27	117					0	0	1	0	0
ZMAT4	79698	broad.mit.edu	37	8	40532281	40532281	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:40532281C>T	ENST00000297737.6	-	5	665	c.519G>A	c.(517-519)gcG>gcA	p.A173A	ZMAT4_ENST00000315769.7_Intron	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	173						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			CAACTCTTGCCGCATTCTTTT	0.478000													92	131					0	0	1	0	0
FETUB	26998	broad.mit.edu	37	3	186360338	186360338	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:186360338C>G	ENST00000265029.3	+	3	516	c.415C>G	c.(415-417)Ctt>Gtt	p.L139V	RP11-134F2.2_ENST00000428501.1_RNA|FETUB_ENST00000382134.3_Intron|FETUB_ENST00000382136.3_Missense_Mutation_p.L102V|FETUB_ENST00000539949.1_Intron|FETUB_ENST00000450521.1_Missense_Mutation_p.L139V|RP11-134F2.2_ENST00000455926.1_RNA|FETUB_ENST00000488561.1_Intron	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	139						extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		TAACTGTACTCTTCGCCCAGG	0.348000													31	37					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71883290	71883290	+	Splice_Site	SNP	A	A	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:71883290A>C	ENST00000258104.3	+	42	4786		c.e42-1		DYSF_ENST00000409651.1_Splice_Site|DYSF_ENST00000410020.3_Splice_Site|DYSF_ENST00000409744.1_Splice_Site|DYSF_ENST00000409762.1_Splice_Site|DYSF_ENST00000429174.2_Splice_Site|DYSF_ENST00000413539.2_Splice_Site|DYSF_ENST00000410041.1_Splice_Site|DYSF_ENST00000479049.2_Splice_Site|DYSF_ENST00000409582.3_Splice_Site|DYSF_ENST00000409366.1_Splice_Site|DYSF_ENST00000394120.2_Splice_Site	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin							cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CATGTGTGGCAGGTCTATGAC	0.502000													88	111					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72138391	72138391	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:72138391G>A	ENST00000555818.1	+	8	3159	c.2811G>A	c.(2809-2811)gaG>gaA	p.E937E	SIPA1L1_ENST00000358550.2_Silent_p.E937E|SIPA1L1_ENST00000537413.1_Silent_p.E412E|SIPA1L1_ENST00000381232.3_Silent_p.E937E	NM_001284247.1|NM_015556.1	NP_001271176.1|NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	937					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		AGATCAAAGAGATTGTCAAAA	0.403000													15	39					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102482317	102482317	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:102482317G>C	ENST00000321521.9	+	6	1147	c.574G>C	c.(574-576)Gaa>Caa	p.E192Q	PPIP5K2_ENST00000358359.3_Missense_Mutation_p.E192Q|PPIP5K2_ENST00000414217.1_Missense_Mutation_p.E192Q|PPIP5K2_ENST00000513500.1_3'UTR			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	192					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						AGTCAGTGCAGAAGATCACAA	0.353000													35	60					0	0	1	0	0
ZNF148	7707	broad.mit.edu	37	3	125032343	125032343	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:125032343G>C	ENST00000360647.4	-	4	627	c.142C>G	c.(142-144)Caa>Gaa	p.Q48E	ZNF148_ENST00000485866.1_Missense_Mutation_p.Q48E|ZNF148_ENST00000468369.1_Intron|ZNF148_ENST00000544464.1_Intron|ZNF148_ENST00000484491.1_Missense_Mutation_p.Q48E|ZNF148_ENST00000492394.1_Missense_Mutation_p.Q48E	NM_021964.2	NP_068799.2	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	48					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						CTTCGATCTTGAAGTACTGAA	0.453000													32	133					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49631272	49631272	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:49631272G>C	ENST00000334186.4	+	2	491	c.142G>C	c.(142-144)Gag>Cag	p.E48Q	PPFIA3_ENST00000602351.1_Missense_Mutation_p.E48Q	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	48						cell surface|cytoplasm	protein binding	p.E48K(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GACGCTGCGCGAGGCACAGGA	0.736000													39	33					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76256956	76256956	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:76256956C>T	ENST00000529032.1	+	19	3389	c.3389C>T	c.(3388-3390)tCa>tTa	p.S1130L	C11orf30_ENST00000525038.1_Missense_Mutation_p.S1131L|C11orf30_ENST00000524767.1_Missense_Mutation_p.S1145L|C11orf30_ENST00000533248.1_Missense_Mutation_p.S1039L|C11orf30_ENST00000525919.1_Missense_Mutation_p.S1131L|C11orf30_ENST00000343878.3_Intron|C11orf30_ENST00000334736.3_Missense_Mutation_p.S1130L|C11orf30_ENST00000524490.1_Missense_Mutation_p.S1032L			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	1130					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						AAGCTGACATCACCAGTTACA	0.438000													48	56					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7585318	7585318	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:7585318C>G	ENST00000379802.3	+	24	8164	c.7823C>G	c.(7822-7824)tCt>tGt	p.S2608C	DSP_ENST00000418664.2_Missense_Mutation_p.S2009C	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2608	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGGAGCAGCTCTTTTTCAGAC	0.458000													70	64					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15629087	15629087	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:15629087G>A	ENST00000281513.5	-	12	1039	c.1014C>T	c.(1012-1014)ttC>ttT	p.F338F	NBAS_ENST00000441750.1_Silent_p.F338F	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	338										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						GTTTCCCTGAGAAGTGAATGG	0.453000													50	70					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996492	140996492	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chrX:140996492C>A	ENST00000285879.4	+	4	3588	c.3302C>A	c.(3301-3303)tCc>tAc	p.S1101Y	MAGEC1_ENST00000406005.2_Missense_Mutation_p.S168Y	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1101	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					ACCTTTCCATCCTCTTACAAG	0.453000										HNSCC(15;0.026)			4	120					0.00909568	0.00913455	1	1	0
FLAD1	80308	broad.mit.edu	37	1	154962920	154962920	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:154962920G>A	ENST00000292180.3	+	5	1792	c.1470G>A	c.(1468-1470)cgG>cgA	p.R490R	FLAD1_ENST00000368433.1_3'UTR|FLAD1_ENST00000405236.2_Intron|FLAD1_ENST00000368428.1_Silent_p.R31R|FLAD1_ENST00000295530.2_Intron|FLAD1_ENST00000315144.10_Silent_p.R393R|FLAD1_ENST00000368432.1_Silent_p.R393R	NM_025207.4	NP_079483.3	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	490	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCACCCGCCGGACTGACCCCT	0.627000													20	78					0	0	1	0	0
VPS28	51160	broad.mit.edu	37	8	145649499	145649499	+	Missense_Mutation	SNP	C	C	T	rs151274166	by1000genomes	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:145649499C>T	ENST00000377348.2	-	9	562	c.473G>A	c.(472-474)cGa>cAa	p.R158Q	VPS28_ENST00000526054.1_Missense_Mutation_p.R158Q|VPS28_ENST00000292510.4_Missense_Mutation_p.R158Q|VPS28_ENST00000529182.1_Missense_Mutation_p.R158Q	NM_183057.1	NP_898880.1	Q9UK41	VPS28_HUMAN	vacuolar protein sorting 28 homolog (S. cerevisiae)	158	VPS28 C-terminal.				cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CATCAGCTCTCGCAGGTCGGG	0.682000													50	70					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42144787	42144787	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr20:42144787G>A	ENST00000444063.1	+	4	694	c.562G>A	c.(562-564)Gag>Aag	p.E188K	L3MBTL1_ENST00000373135.3_Missense_Mutation_p.E188K|L3MBTL1_ENST00000418998.1_Missense_Mutation_p.E256K|L3MBTL1_ENST00000373134.1_Missense_Mutation_p.E188K|L3MBTL1_ENST00000457824.1_3'UTR|L3MBTL1_ENST00000427442.2_Missense_Mutation_p.E256K			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	188					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						TAGCACCCCAGAGAGTGAGGA	0.522000													16	58					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133945110	133945110	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr9:133945110G>A	ENST00000361069.4	+	17	3075	c.2942G>A	c.(2941-2943)gGc>gAc	p.G981D	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	981	Laminin EGF-like 11.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CACGAGAACGGCACATGCGTG	0.657000													16	0					0	0	1	0	0
EXOSC10	5394	broad.mit.edu	37	1	11147910	11147910	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:11147910C>T	ENST00000544779.1	-	8	897	c.892G>A	c.(892-894)Gtg>Atg	p.V298M	EXOSC10_ENST00000376936.4_Missense_Mutation_p.V298M|EXOSC10_ENST00000304457.7_Missense_Mutation_p.V298M			Q01780	EXOSX_HUMAN	exosome component 10	298					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding	p.V298M(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		TTGAGTTCCACGAGTTCATCC	0.373000													58	68					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													4	61					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32048704	32048704	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:32048704G>A	ENST00000438447.1	+	8	1967	c.1579G>A	c.(1579-1581)Gac>Aac	p.D527N	PDZD2_ENST00000282493.3_Missense_Mutation_p.D527N			O15018	PDZD2_HUMAN	PDZ domain containing 2	527					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GCGGAATGGGGACCCCCGGAT	0.557000													25	28					0	0	1	0	0
ZNF346	23567	broad.mit.edu	37	5	176471534	176471534	+	Splice_Site	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:176471534G>C	ENST00000503039.1	+	5	596	c.592G>C	c.(592-594)Gcc>Ccc	p.A198P	ZNF346_ENST00000511834.1_Splice_Site_p.A173P|ZNF346_ENST00000503425.1_Splice_Site_p.A141P|ZNF346_ENST00000261948.4_Splice_Site_p.A198P|ZNF346_ENST00000506693.1_Intron|ZNF346_ENST00000358149.3_Splice_Site_p.A173P|ZNF346_ENST00000512315.1_Intron			Q9UL40	ZN346_HUMAN	zinc finger protein 346	173						cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	14	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TAAGGTGGAAGGTACTGGTTT	0.552000													39	54					0	0	1	0	0
UBR3	130507	broad.mit.edu	37	2	170857818	170857818	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:170857818C>T	ENST00000272793.5	+	27	3973	c.3923C>T	c.(3922-3924)tCa>tTa	p.S1308L	UBR3_ENST00000392631.1_Missense_Mutation_p.S129L|UBR3_ENST00000418381.1_Missense_Mutation_p.S1308L			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1308					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						TTGAAGAGTTCATGTCTCTTG	0.313000													18	61					0	0	1	0	0
GLI4	2738	broad.mit.edu	37	8	144358467	144358467	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:144358467G>C	ENST00000340042.1	+	4	709	c.624G>C	c.(622-624)gaG>gaC	p.E208D	GLI4_ENST00000523812.1_3'UTR|ZFP41_ENST00000522452.1_3'UTR|GLI4_ENST00000523522.1_Missense_Mutation_p.E208D	NM_138465.3	NP_612474.1	P10075	GLI4_HUMAN	GLI family zinc finger 4	208						nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(1)|lung(5)	9	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			ACACGGGCGAGAAGCCCTACG	0.672000													23	21					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940774	144940774	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:144940774G>A	ENST00000525985.1	-	2	6719	c.6648C>T	c.(6646-6648)gtC>gtT	p.V2216V				P58107	EPIPL_HUMAN	epiplakin 1	2216						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTAGCGCTTGACGCGGTCGT	0.627000													86	78					0	0	1	0	0
TRAJ52	28703	broad.mit.edu	37	14	22955247	22955247	+	RNA	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:22955247G>C	ENST00000390486.1	+	0	32																											ATGGAAAGCTGACATTTGGAC	0.473000													12	12					0	0	1	0	0
PGM2L1	283209	broad.mit.edu	37	11	74054024	74054024	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:74054024C>A	ENST00000298198.4	-	11	1659	c.1348G>T	c.(1348-1350)Ggg>Tgg	p.G450W		NM_173582.3	NP_775853.2	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	450					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(11;3.32e-06)					GCACTCACCCCATCTTTATCC	0.368000													61	74					3.63617e-18	3.86652e-18	1	1	0
ARHGEF19	128272	broad.mit.edu	37	1	16534659	16534659	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:16534659G>A	ENST00000270747.3	-	3	610	c.474C>T	c.(472-474)gtC>gtT	p.V158V		NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	158					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		GCTCTAGGAAGACAGCGTGGG	0.662000													28	38					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91715563	91715563	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:91715563C>T	ENST00000359028.2	+	37	9283	c.9058C>T	c.(9058-9060)Cat>Tat	p.H3020Y	AKAP9_ENST00000356239.3_Missense_Mutation_p.H3016Y|AKAP9_ENST00000358100.2_Missense_Mutation_p.H2966Y			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3020					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTCTCAATCTCATGAGAGCTT	0.358000			T	BRAF	papillary thyroid								74	80					0	0	1	0	0
NADK2	133686	broad.mit.edu	37	5	36219758	36219758	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:36219758G>A	ENST00000397338.1	-	5	316	c.95C>T	c.(94-96)cCc>cTc	p.P32L	NADK2_ENST00000506945.1_Missense_Mutation_p.P32L|NADK2_ENST00000381937.4_Missense_Mutation_p.P195L|NADK2_ENST00000282512.3_Missense_Mutation_p.P32L|NADK2_ENST00000514504.1_Missense_Mutation_p.P195L					NAD kinase 2, mitochondrial																		ATATCGAACGGGCAGGCATAA	0.348000													29	42					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14861711	14861711	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:14861711C>A	ENST00000285046.5	+	1	1243	c.1133C>A	c.(1132-1134)cCa>cAa	p.P378Q	FGD5_ENST00000543601.1_Missense_Mutation_p.P137Q	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	378					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						GAGCAGGCACCAAAGCTGGGG	0.592000													45	43					5.44703e-19	5.81842e-19	1	1	0
RPS6KA5	9252	broad.mit.edu	37	14	91338436	91338436	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:91338436G>C	ENST00000261991.3	-	17	2564	c.2391C>G	c.(2389-2391)ttC>ttG	p.F797L	RPS6KA5_ENST00000536315.2_Missense_Mutation_p.F718L	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	797					axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		CTGAGTCCGAGAACTGGAAGA	0.473000													61	83					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23898246	23898246	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:23898246C>T	ENST00000355349.3	-	14	1487	c.1325G>A	c.(1324-1326)cGc>cAc	p.R442H		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	442	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GGCATTGATGCGCGTCACCAT	0.557000													50	56					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133911664	133911664	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr9:133911664C>T	ENST00000361069.4	+	4	1054	c.921C>T	c.(919-921)ttC>ttT	p.F307F	LAMC3_ENST00000480883.1_3'UTR	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	307	Laminin EGF-like 1.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GCCTGCCCTTCTTCCAGGACC	0.701000													60	2					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3237383	3237383	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:3237383C>G	ENST00000355072.5	+	63	8808	c.8663C>G	c.(8662-8664)tCt>tGt	p.S2888C		NM_002111.6	NP_002102	P42858	HD_HUMAN	huntingtin	2888					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CTCCTGCTCTCTGAGCAGCTC	0.627000													4	33					0	0	1	0	0
KIAA0922	23240	broad.mit.edu	37	4	154524521	154524521	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:154524521G>C	ENST00000409663.3	+	24	2755	c.2703G>C	c.(2701-2703)atG>atC	p.M901I	KIAA0922_ENST00000409959.3_Missense_Mutation_p.M902I|KIAA0922_ENST00000440693.1_Missense_Mutation_p.M818I	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	901						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				TGGAATTCATGAAAACAAGAC	0.398000													35	47					0	0	1	0	0
EMP3	2014	broad.mit.edu	37	19	48832670	48832670	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:48832670C>T	ENST00000270221.6	+	4	544	c.243C>T	c.(241-243)ttC>ttT	p.F81F	EMP3_ENST00000596315.1_Silent_p.F12F|EMP3_ENST00000597279.1_Silent_p.F81F	NM_001425.2	NP_001416.1	P54852	EMP3_HUMAN	epithelial membrane protein 3	81					cell growth|negative regulation of cell proliferation	integral to membrane				lung(1)	1		all_epithelial(76;6.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.00989)|Prostate(7;0.0143)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		GTCTCTCCTTCATCCTGTTCA	0.592000													71	50					0	0	1	0	0
PPP1R36	145376	broad.mit.edu	37	14	65031549	65031549	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:65031549C>G	ENST00000298705.1	+	4	359	c.263C>G	c.(262-264)tCa>tGa	p.S88*	RP11-973N13.3_ENST00000554454.1_RNA|RP11-973N13.3_ENST00000556634.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	88																	GGTCCAGCTTCAGACAGGTAG	0.408000													146	158					0	0	1	0	0
FOXA2	3170	broad.mit.edu	37	20	22562945	22562945	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr20:22562945G>C	ENST00000419308.2	-	2	1119	c.935C>G	c.(934-936)tCg>tGg	p.S312W	FOXA2_ENST00000377115.4_Missense_Mutation_p.S306W	NM_021784.4	NP_068556.2	Q9Y261	FOXA2_HUMAN	forkhead box A2	312					cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|urinary_tract(1)	22	Lung NSC(19;0.188)					GGAGGCGCTCGAGTGAGGCGA	0.766000													7	14					0	0	1	0	0
CCNI	10983	broad.mit.edu	37	4	77969763	77969763	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:77969763G>C	ENST00000237654.4	-	7	1319	c.743C>G	c.(742-744)tCt>tGt	p.S248C	CCNI_ENST00000537948.1_Missense_Mutation_p.S234C	NM_006835.2	NP_006826.1	Q14094	CCNI_HUMAN	cyclin I	248					spermatogenesis					NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	9						CTGCAGAGTAGAAAGGTGATG	0.478000													30	28					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173916674	173916674	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:173916674C>G	ENST00000367696.2	-	15	2921	c.2570G>C	c.(2569-2571)aGa>aCa	p.R857T	RC3H1_ENST00000367694.2_Missense_Mutation_p.R857T|RC3H1_ENST00000258349.4_Missense_Mutation_p.R857T			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	857					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						TGCTGCTCTTCTCTGAAGATC	0.438000													24	74					0	0	1	0	0
GINS4	84296	broad.mit.edu	37	8	41397245	41397245	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:41397245G>T	ENST00000523277.2	+	5	513	c.346G>T	c.(346-348)Gag>Tag	p.E116*	GINS4_ENST00000276533.3_Nonsense_Mutation_p.E116*|RP11-360L9.4_ENST00000523081.1_RNA|GINS4_ENST00000518671.1_Nonsense_Mutation_p.E116*			Q9BRT9	SLD5_HUMAN	GINS complex subunit 4 (Sld5 homolog)	116					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm				breast(1)|lung(2)|skin(1)	4	Ovarian(28;0.014)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.00732)|Lung NSC(58;0.0207)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00329)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			AACACGTCCTGAGGGGGAGCC	0.507000													36	43					5.43694e-19	5.81842e-19	1	1	0
FSD1	79187	broad.mit.edu	37	19	4305963	4305963	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:4305963C>T	ENST00000221856.6	+	2	183	c.36C>T	c.(34-36)atC>atT	p.I12I	FSD1_ENST00000597590.1_Silent_p.I12I	NM_024333.2	NP_077309.1	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing 1	12					cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGATCATCAAAACACTGG	0.527000													19	83					0	0	1	0	0
ZNF540	163255	broad.mit.edu	37	19	38102674	38102674	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:38102674C>T	ENST00000592533.1	+	5	825	c.493C>T	c.(493-495)Cac>Tac	p.H165Y	ZNF540_ENST00000316433.4_Missense_Mutation_p.H165Y|ZNF540_ENST00000589117.1_Missense_Mutation_p.H133Y|ZNF540_ENST00000586792.1_3'UTR|ZNF540_ENST00000343599.5_Missense_Mutation_p.H165Y	NM_152606.4	NP_689819.1			zinc finger protein 540											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(13)|lung(8)|skin(1)	28			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCAGAGAATTCACAATAGTGA	0.338000													20	98					0	0	1	0	0
PUS10	150962	broad.mit.edu	37	2	61236138	61236138	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:61236138C>T	ENST00000316752.6	-	3	400	c.139G>A	c.(139-141)Gaa>Aaa	p.E47K	PUS10_ENST00000407787.1_Missense_Mutation_p.E47K	NM_144709.2	NP_653310.2	Q3MIT2	PUS10_HUMAN	pseudouridylate synthase 10	47					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)	22			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)			TTCTGTAGTTCATTGAGCAAC	0.353000													15	18					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143565395	143565395	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:143565395G>C	ENST00000517894.1	+	12	3082	c.2188G>C	c.(2188-2190)Gag>Cag	p.E730Q	BAI1_ENST00000323289.5_Missense_Mutation_p.E730Q			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	730					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CAAGTGGGAGGAGGCCCAGCT	0.622000													83	68					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48428949	48428949	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:48428949C>T	ENST00000224605.2	-	2	1202	c.937G>A	c.(937-939)Gcc>Acc	p.A313T		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	313					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity	p.A313S(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						TGTGCGTGGGCGCGCGGCGGC	0.721000													12	39					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53667911	53667911	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:53667911G>A	ENST00000600412.1	-	2	1752	c.1637C>T	c.(1636-1638)tCa>tTa	p.S546L	ZNF665_ENST00000396424.3_Missense_Mutation_p.S611L			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	546					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TGCAAGATGTGAATTTTGAGT	0.393000													39	80					0	0	1	0	0
ZNF486	90649	broad.mit.edu	37	19	20308220	20308220	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:20308220G>A	ENST00000335117.8	+	4	758	c.701G>A	c.(700-702)aGa>aAa	p.R234K	CTC-260E6.6_ENST00000586657.1_RNA|CTC-260E6.6_ENST00000585498.1_RNA|CTC-260E6.6_ENST00000593655.1_RNA	NM_052852.3	NP_443084.2	Q96H40	ZN486_HUMAN	zinc finger protein 486	234					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11						ACTCATACTAGAGAGAAACCC	0.363000													20	48					0	0	1	0	0
IGDCC4	57722	broad.mit.edu	37	15	65687479	65687479	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:65687479C>G	ENST00000352385.2	-	8	1738	c.1529G>C	c.(1528-1530)gGa>gCa	p.G510A		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	510	Fibronectin type-III 1.					integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						GCGGCTGGCTCCCAGCTGGGA	0.567000													9	66					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32017839	32017839	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:32017839C>G	ENST00000375244.3	-	27	9576	c.9375G>C	c.(9373-9375)aaG>aaC	p.K3125N	TNXB_ENST00000375247.2_Missense_Mutation_p.K3123N			P22105	TENX_HUMAN	tenascin XB	3170	Fibronectin type-III 23.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						ACAGGTTCATCTTGTATTTAT	0.632000													29	90					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53669303	53669303	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:53669303G>T	ENST00000600412.1	-	2	360	c.245C>A	c.(244-246)tCa>tAa	p.S82*	ZNF665_ENST00000396424.3_Nonsense_Mutation_p.S147*			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	82					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		AGGGAGATGTGACTGAAAGCT	0.378000													58	95					3.73128e-16	3.94091e-16	1	1	0
DCHS2	54798	broad.mit.edu	37	4	155254201	155254201	+	Silent	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:155254201G>T	ENST00000357232.4	-	9	1661	c.1662C>A	c.(1660-1662)ctC>ctA	p.L554L	DCHS2_ENST00000339452.1_Silent_p.L1053L	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCTCGGCCCTGAGAGTCAGCG	0.642000													50	39					1.19451e-25	1.28766e-25	1	1	0
ZNF717	100131827	broad.mit.edu	37	3	75790798	75790798	+	Translation_Start_Site	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:75790798G>A	ENST00000478296.1	-	0	273				ZNF717_ENST00000477374.1_Silent_p.D49D|ZNF717_ENST00000400845.3_Silent_p.D42D|ZNF717_ENST00000491507.1_5'UTR|ZNF717_ENST00000422325.1_Silent_p.D49D			C9JSV9	C9JSV9_HUMAN	zinc finger protein 717						regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			autonomic_ganglia(6)|endometrium(3)|lung(2)|ovary(1)|stomach(7)	19						CCAGCATCACGTCCCTGTACA	0.502000													4	9					0	0	1	0	0
NMBR	4829	broad.mit.edu	37	6	142399856	142399856	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:142399856G>C	ENST00000258042.1	-	2	747	c.607C>G	c.(607-609)Caa>Gaa	p.Q203E		NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	203					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		TCATCTGTTTGAGGGTATGGG	0.413000													83	95					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147128781	147128781	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:147128781C>T	ENST00000282928.4	+	1	1611	c.882C>T	c.(880-882)cgC>cgT	p.R294R		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	294					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						ACCACATCCGCGTGCACACGG	0.572000													18	135					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000405598.1_Silent_p.S372S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	74					0	0	1	0	0
TRAV18	28665	broad.mit.edu	37	14	22471899	22471899	+	RNA	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:22471899T>C	ENST00000390446.3	+	0	427																											CGTGTACTACTGCGCTCTGAG	0.602000													25	14					0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156737729	156737729	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:156737729C>G	ENST00000271526.4	+	1	438	c.166C>G	c.(166-168)Cag>Gag	p.Q56E	PRCC_ENST00000491853.1_Intron|PRCC_ENST00000353233.3_Missense_Mutation_p.Q56E	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	56	Mediates interaction with MAD2L2.				cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TCCGCCCCCTCAGATGCTGGC	0.697000			T	TFE3	papillary renal								9	3					0	0	1	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45504700	45504700	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:45504700C>T	ENST00000359600.5	-	8	2007	c.1802G>A	c.(1801-1803)tGg>tAg	p.W601*		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	601							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					GTGGCCCACCCAGCCCTCCAG	0.512000													47	46					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751448	19751448	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr13:19751448G>A	ENST00000400113.3	-	4	779	c.675C>T	c.(673-675)acC>acT	p.T225T		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	225					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GATTGAGGTTGGTGTACGTGG	0.552000													99	139					0	0	1	0	0
NOB1	28987	broad.mit.edu	37	16	69776432	69776432	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:69776432G>A	ENST00000268802.5	-	9	1071	c.1042C>T	c.(1042-1044)Cag>Tag	p.Q348*	CTD-2033A16.3_ENST00000575838.1_RNA	NM_014062.1	NP_054781.1	Q9ULX3	NOB1_HUMAN	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)	348						nucleus	metal ion binding|protein binding			breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						AGTCGCAGCTGAGGGAAGCGC	0.562000													63	53					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41711077	41711077	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr21:41711077G>A	ENST00000400454.1	-	7	1953	c.1476C>T	c.(1474-1476)gtC>gtT	p.V492V		NM_001271534.1|NM_001389.3	NP_001258463.1|NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	492	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGTACAGGACGACTCCCGCCG	0.522000													39	2					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36748211	36748211	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:36748211C>G	ENST00000354618.5	+	3	271	c.47C>G	c.(46-48)tCa>tGa	p.S16*	THRAP3_ENST00000469141.2_Nonsense_Mutation_p.S16*	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	16	Arg-rich.|Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TCTTCTCGCTCAAGATCTGCA	0.448000			T	USP6	aneurysmal bone cysts								38	42					0	0	1	0	0
UBXN7	26043	broad.mit.edu	37	3	196089511	196089511	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:196089511G>C	ENST00000296328.4	-	9	956	c.882C>G	c.(880-882)atC>atG	p.I294M	UBXN7_ENST00000428095.1_Missense_Mutation_p.I132M|UBXN7_ENST00000535858.1_Missense_Mutation_p.I146M	NM_015562.1	NP_056377.1	O94888	UBXN7_HUMAN	UBX domain protein 7	294							protein binding			NS(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						AGGAGGCTCTGATGGCAGCTT	0.413000													66	70					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112272	57112272	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:57112272C>T	ENST00000454682.1	-	3	3323	c.3042G>A	c.(3040-3042)gtG>gtA	p.V1014V	NACA_ENST00000551793.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						AGGGAGGAGTCACAGCTGGGG	0.657000			T	BCL6	NHL								4	94					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178936438	178936438	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:178936438C>T	ENST00000286063.6	-	1	1044	c.727G>A	c.(727-729)Gtg>Atg	p.V243M	PDE11A_ENST00000358450.4_Intron	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A		GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GCCCCTTCCACCAGGAAAAGA	0.502000									Primary Pigmented Nodular Adrenocortical Disease, Familial				42	53					0	0	1	0	0
SIK3	23387	broad.mit.edu	37	11	116732089	116732089	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:116732089G>A	ENST00000375300.1	-	18	2187	c.2182C>T	c.(2182-2184)Cag>Tag	p.Q728*	SIK3_ENST00000292055.4_Nonsense_Mutation_p.Q670*|SIK3_ENST00000542607.1_Nonsense_Mutation_p.Q670*|SIK3_ENST00000488337.1_Intron|SIK3_ENST00000446921.2_Nonsense_Mutation_p.Q728*|SIK3_ENST00000434315.2_Nonsense_Mutation_p.Q569*|SIK3_ENST00000375288.1_Intron			Q9Y2K2	SIK3_HUMAN	SIK family kinase 3	670	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	57						CTTGAAGGCTGAATCCTTAAC	0.463000											OREG0003492	type=REGULATORY REGION|Gene=BC035583|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	33	40					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712211	140712211	+	Missense_Mutation	SNP	C	C	T	rs149280390	byFrequency	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:140712211C>T	ENST00000517417.1	+	1	1960	c.1960C>T	c.(1960-1962)Ctc>Ttc	p.L654F	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.L654F	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGCCCCCGCTCTCCGCCAC	0.697000													89	79					0	0	1	0	0
DNAJC16	23341	broad.mit.edu	37	1	15855611	15855611	+	Missense_Mutation	SNP	G	G	C	rs143679565		TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:15855611G>C	ENST00000375847.3	+	2	175	c.11G>C	c.(10-12)aGa>aCa	p.R4T	DNAJC16_ENST00000375838.1_Missense_Mutation_p.R4T|DNAJC16_ENST00000375849.1_Missense_Mutation_p.R4T	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	4					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ATGGAAGTGAGAAAGTTGAGC	0.438000													54	64					0	0	1	0	0
RFXAP	5994	broad.mit.edu	37	13	37393936	37393936	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr13:37393936G>T	ENST00000255476.2	+	1	576	c.442G>T	c.(442-444)Gag>Tag	p.E148*		NM_000538.3	NP_000529.1	O00287	RFXAP_HUMAN	regulatory factor X-associated protein	148						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)	4		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;3.5e-07)|Epithelial(112;1.27e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.0069)|BRCA - Breast invasive adenocarcinoma(63;0.0116)|GBM - Glioblastoma multiforme(144;0.0405)		AGGCTGCAGCGAGACCACGAG	0.622000													7	10					1.06961e-07	1.10488e-07	1	1	0
PER3	8863	broad.mit.edu	37	1	7887272	7887272	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:7887272G>A	ENST00000377532.3	+	17	2507	c.2283G>A	c.(2281-2283)tcG>tcA	p.S761S	RP3-467L1.4_ENST00000451646.1_RNA|PER3_ENST00000361923.2_Silent_p.S753S			P56645	PER3_HUMAN	period circadian clock 3	753					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGCAGCTCGAACACCGGCT	0.667000													26	56					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123310939	123310939	+	Silent	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:123310939T>C	ENST00000358487.5	-	5	761	c.489A>G	c.(487-489)gaA>gaG	p.E163E	FGFR2_ENST00000346997.2_Silent_p.E163E|FGFR2_ENST00000360144.3_Silent_p.E74E|FGFR2_ENST00000369056.1_Silent_p.E163E|FGFR2_ENST00000359354.2_Silent_p.E163E|FGFR2_ENST00000369059.1_Silent_p.E48E|FGFR2_ENST00000351936.6_Silent_p.E163E|FGFR2_ENST00000356226.4_Silent_p.E48E|FGFR2_ENST00000490349.1_5'UTR|FGFR2_ENST00000369061.4_Silent_p.E163E|FGFR2_ENST00000357555.5_Silent_p.E74E|FGFR2_ENST00000369060.4_Silent_p.E163E|FGFR2_ENST00000457416.2_Silent_p.E163E	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	163	Heparin-binding.|Ig-like C2-type 2.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GGAGCCGCTTTTCCATCTTTT	0.517000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				43	45					0	0	1	0	0
HTR1E	3354	broad.mit.edu	37	6	87725385	87725385	+	Silent	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:87725385C>G	ENST00000305344.5	+	2	1036	c.333C>G	c.(331-333)ctC>ctG	p.L111L		NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled						G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	GCTCCATCCTCCACCTCTGTG	0.547000													51	62					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38851437	38851437	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:38851437C>G	ENST00000409235.3	+	16	1949	c.1834C>G	c.(1834-1836)Ctg>Gtg	p.L612V	CATSPERG_ENST00000410018.1_Missense_Mutation_p.L572V|CATSPERG_ENST00000215069.4_3'UTR	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	612					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						GGAGCAGCTTCTGATGTATCA	0.612000													12	23					0	0	1	0	0
PIWIL2	55124	broad.mit.edu	37	8	22145090	22145090	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:22145090C>G	ENST00000356766.6	+	7	941	c.793C>G	c.(793-795)Caa>Gaa	p.Q265E	PIWIL2_ENST00000454009.2_Missense_Mutation_p.Q265E|PIWIL2_ENST00000521356.1_Missense_Mutation_p.Q265E	NM_018068.3	NP_060538.2	Q8TC59	PIWL2_HUMAN	piwi-like RNA-mediated gene silencing 2	265					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(14)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	46				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		GAAGGACCATCAAGCTGTCAC	0.438000											OREG0018608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	46					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122078510	122078510	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:122078510C>T	ENST00000334010.7	-	16	2785	c.2364G>A	c.(2362-2364)atG>atA	p.M788I	RP5-1101C3.1_ENST00000592542.1_RNA|CADPS2_ENST00000313070.7_Missense_Mutation_p.M784I|CADPS2_ENST00000449022.2_Missense_Mutation_p.M787I|CADPS2_ENST00000412584.2_Missense_Mutation_p.M784I	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	787	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						CAATATCTTTCATTAAAACCT	0.413000													18	19					0	0	1	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37678383	37678383	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr13:37678383G>A	ENST00000379800.3	-	1	1420	c.1011C>T	c.(1009-1011)aaC>aaT	p.N337N		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	337					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		TTCACGCTTAGTTATCTTTCA	0.458000													64	54					0	0	1	0	0
FASTK	10922	broad.mit.edu	37	7	150775945	150775945	+	Silent	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:150775945C>G	ENST00000297532.6	-	3	746	c.669G>C	c.(667-669)ctG>ctC	p.L223L	FASTK_ENST00000540185.1_Intron|FASTK_ENST00000353841.2_Silent_p.L82L|FASTK_ENST00000489884.1_Intron|FASTK_ENST00000482571.1_Intron	NM_006712.4	NP_006703.1	Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase	223					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(4)|stomach(2)	6			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		GGCTGCTGATCAGATGCTGCC	0.627000													17	34					0	0	1	0	0
SURF4	6836	broad.mit.edu	37	9	136230392	136230392	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr9:136230392C>T	ENST00000371989.3	-	6	916	c.787G>A	c.(787-789)Gat>Aat	p.D263N	SURF4_ENST00000545297.1_3'UTR|SURF4_ENST00000485435.2_Intron	NM_001280788.1|NM_001280790.1|NM_001280791.1|NM_033161.2	NP_001267717.1|NP_001267719.1|NP_001267720.1|NP_149351.1	O15260	SURF4_HUMAN	surfeit 4	263						endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding			kidney(1)|large_intestine(2)|lung(5)	8				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		TTCTTCTCATCCATGGAGACA	0.567000													42	2					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121220493	121220493	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:121220493C>G	ENST00000297848.3	+	11	1484	c.1214C>G	c.(1213-1215)tCt>tGt	p.S405C	COL14A1_ENST00000537875.1_Missense_Mutation_p.S405C|COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000309791.4_Missense_Mutation_p.S405C|COL14A1_ENST00000247781.3_Missense_Mutation_p.S310C	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	405	Fibronectin type-III 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GGAACTGTATCTTCCACAGTG	0.388000													16	18					0	0	1	0	0
SMC3	9126	broad.mit.edu	37	10	112340729	112340729	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:112340729G>C	ENST00000361804.4	+	8	623	c.497G>C	c.(496-498)aGa>aCa	p.R166T	SMC3_ENST00000462899.1_3'UTR	NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	166					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		GCTGGTACTAGAGTGTATGAC	0.323000													39	37					0	0	1	0	0
ATP5C1	509	broad.mit.edu	37	10	7844765	7844765	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:7844765C>T	ENST00000356708.7	+	8	917	c.838C>T	c.(838-840)Caa>Taa	p.Q280*	ATP5C1_ENST00000541227.1_Nonsense_Mutation_p.Q233*|ATP5C1_ENST00000335698.4_Nonsense_Mutation_p.Q280*|ATP5C1_ENST00000493053.1_3'UTR	NM_001001973.1	NP_001001973.1	P36542	ATPG_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	280					oxidative phosphorylation|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(2)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	16						CCGTACCCGCCAAGCTGTCAT	0.363000													27	23					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38743562	38743562	+	Silent	SNP	T	T	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:38743562T>C	ENST00000359357.3	+	11	1400	c.1146T>C	c.(1144-1146)taT>taC	p.Y382Y	DNAH8_ENST00000441566.1_Silent_p.Y382Y|DNAH8_ENST00000449981.2_Silent_p.Y599Y					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGCAAACATATTCAACCTTGA	0.299000													27	22					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52488661	52488661	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:52488661C>T	ENST00000261839.7	-	39	5001	c.4840G>A	c.(4840-4842)Gaa>Aaa	p.E1614K	RP11-430B1.2_ENST00000560518.1_lincRNA	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	1614	Dilute.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		AGCCATTCTTCTAAGTAGCTG	0.488000													35	75					0	0	1	0	0
CUL4A	8451	broad.mit.edu	37	13	113915001	113915001	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr13:113915001G>A	ENST00000451881.1	+	19	2061	c.1812G>A	c.(1810-1812)atG>atA	p.M604I	CUL4A_ENST00000326335.4_Missense_Mutation_p.M604I|CUL4A_ENST00000375441.3_Missense_Mutation_p.M604I|CUL4A_ENST00000375440.4_Missense_Mutation_p.M704I	NM_001278513.1|NM_003589.2	NP_001265442.1|NP_003580.1	Q13619	CUL4A_HUMAN	cullin 4A	704					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|skin(1)	17	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			TCAGAATAATGAAGATGAGAA	0.318000													11	13					0	0	1	0	0
EGR4	1961	broad.mit.edu	37	2	73518804	73518804	+	Missense_Mutation	SNP	G	G	C	rs146026377	byFrequency	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:73518804G>C	ENST00000545030.1	-	2	1625	c.1551C>G	c.(1549-1551)atC>atG	p.I517M	EGR4_ENST00000436467.2_Missense_Mutation_p.I414M	NM_001965.3	NP_001956.3	B7ZKU3	B7ZKU3_HUMAN	early growth response 4	413						intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						TGCGGAGGCAGATGCGGCACT	0.662000													29	42					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82643221	82643221	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:82643221G>A	ENST00000533655.1	+	6	1053	c.841G>A	c.(841-843)Gag>Aag	p.E281K	C11orf82_ENST00000329143.3_5'UTR|C11orf82_ENST00000430323.2_Missense_Mutation_p.E281K|C11orf82_ENST00000528759.1_3'UTR|C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000525388.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	281					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						CTCCATTGCAGAGGCCACTGG	0.408000													43	53					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440305	40440305	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:40440305C>T	ENST00000319592.4	-	4	1315	c.606G>A	c.(604-606)gaG>gaA	p.E202E	RBM47_ENST00000295971.7_Silent_p.E202E|RBM47_ENST00000381795.6_Silent_p.E202E|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381793.2_Silent_p.E202E|RBM47_ENST00000514014.1_Silent_p.E164E			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	202	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CGCGGTGGCTCTCGTACTCCA	0.662000													74	61					0	0	1	0	0
H6PD	9563	broad.mit.edu	37	1	9324568	9324568	+	Silent	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:9324568C>A	ENST00000377403.2	+	5	2318	c.2016C>A	c.(2014-2016)atC>atA	p.I672I	H6PD_ENST00000602477.1_Silent_p.I683I	NM_001282587.1|NM_004285.3	NP_001269516.1|NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	672	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	GCGCCCAGATCTATGCCAGGG	0.652000													33	96					1.74807e-11	1.82171e-11	1	1	0
RAB33A	9363	broad.mit.edu	37	X	129318670	129318670	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chrX:129318670G>T	ENST00000257017.4	+	2	1084	c.670G>T	c.(670-672)Gag>Tag	p.E224*		NM_004794.2	NP_004785.1	Q14088	RB33A_HUMAN	RAB33A, member RAS oncogene family	224					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(5)	11						GCAGAAACTGGAGTTCCCACA	0.443000													32	1					2.61193e-14	2.75248e-14	1	1	0
PDE4B	5142	broad.mit.edu	37	1	66798096	66798096	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:66798096C>T	ENST00000371045.5	+	1	410	c.24C>T	c.(22-24)ttC>ttT	p.F8F	PDE4B_ENST00000423207.2_Intron|PDE4B_ENST00000371049.3_Intron|PDE4B_ENST00000329654.4_Intron	NM_001037339.1	NP_001032416.1	Q07343	PDE4B_HUMAN	phosphodiesterase 4B, cAMP-specific	0					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	37					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	GGGGCACCTTCAGTAGCACCG	0.557000													48	42					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													4	62					0	0	1	0	0
KDM1B	221656	broad.mit.edu	37	6	18218020	18218020	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:18218020C>T	ENST00000388870.2	+	21	2533	c.2292C>T	c.(2290-2292)atC>atT	p.I764I	KDM1B_ENST00000297792.5_Silent_p.I531I|KDM1B_ENST00000397244.1_Silent_p.I532I|KDM1B_ENST00000546309.2_Silent_p.I54I			Q8NB78	KDM1B_HUMAN	lysine (K)-specific demethylase 1B	763					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						ACCCATGGATCCAGATGGCAT	0.463000													38	47					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53668734	53668734	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:53668734G>C	ENST00000600412.1	-	2	929	c.814C>G	c.(814-816)Cag>Gag	p.Q272E	ZNF665_ENST00000396424.3_Missense_Mutation_p.Q337E			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TGGATTGTCTGATGGGTAGTC	0.443000													43	79					0	0	1	0	0
ARNT	405	broad.mit.edu	37	1	150799060	150799060	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:150799060G>A	ENST00000358595.5	-	13	1401	c.1201C>T	c.(1201-1203)Cat>Tat	p.H401Y	ARNT_ENST00000505755.1_Missense_Mutation_p.H386Y|ARNT_ENST00000515192.1_Missense_Mutation_p.H387Y|ARNT_ENST00000354396.2_Missense_Mutation_p.H401Y	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	401	PAS 2.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCTTCAGGATGACAGAATTCT	0.328000			T	ETV6	AML								84	36					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75130426	75130426	+	Silent	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:75130426G>C	ENST00000356357.4	-	20	2984	c.2469C>G	c.(2467-2469)ctC>ctG	p.L823L	AREL1_ENST00000557401.1_Intron	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		AGAGTGGTCAGAGCATGCCAA	0.527000													56	96					0	0	1	0	0
CEP135	9662	broad.mit.edu	37	4	56883883	56883883	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:56883883G>T	ENST00000257287.4	+	22	2996	c.2872G>T	c.(2872-2874)Gaa>Taa	p.E958*		NM_025009.4	NP_079285.2	Q66GS9	CP135_HUMAN	centrosomal protein 135kDa	958					centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(26)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	50	Glioma(25;0.08)|all_neural(26;0.101)					TCGATTAGAAGAAGAGCTGAG	0.338000													13	15					9.31168e-06	9.53484e-06	1	1	0
CCDC70	83446	broad.mit.edu	37	13	52440136	52440136	+	Missense_Mutation	SNP	G	G	A	rs78877659	by1000genomes	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr13:52440136G>A	ENST00000242819.4	+	2	918	c.622G>A	c.(622-624)Gga>Aga	p.G208R		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	208						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		CCACATTGCCGGAGAGCAGAT	0.607000													4	114					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2812136	2812136	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:2812136C>T	ENST00000301740.8	+	11	2156	c.1607C>T	c.(1606-1608)tCt>tTt	p.S536F		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	536	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						CGCTCTAGGTCTCCTCAGCGA	0.602000													36	48					0	0	1	0	0
TBC1D16	125058	broad.mit.edu	37	17	77987224	77987224	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:77987224C>G	ENST00000310924.2	-	2	238	c.123G>C	c.(121-123)aaG>aaC	p.K41N		NM_001271844.1|NM_001271845.1|NM_019020.2	NP_001258773.1|NP_001258774.1|NP_061893.2	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	41						intracellular	Rab GTPase activator activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(3)	28	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			AGACATTGTTCTTGGAGTAGA	0.692000													17	8					0	0	1	0	0
PLOD3	8985	broad.mit.edu	37	7	100860035	100860035	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:100860035C>A	ENST00000223127.3	-	2	540	c.142G>T	c.(142-144)Gaa>Taa	p.E48*		NM_001084.4	NP_001075.1	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	48					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	31	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	CCCTCGGTTTCAGCTGTGGCC	0.612000													27	40					2.41591e-17	2.56316e-17	1	1	0
DALRD3	55152	broad.mit.edu	37	3	49053945	49053945	+	Splice_Site	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:49053945C>G	ENST00000440857.1	-	9	1265		c.e9-1		DALRD3_ENST00000395462.4_Splice_Site|DALRD3_ENST00000341949.4_Splice_Site|DALRD3_ENST00000313778.5_Splice_Site|DALRD3_ENST00000441576.2_Splice_Site			Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3						arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding			breast(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CAGGCTGGGTCTGAGGGAGTA	0.567000													23	21					0	0	1	0	0
ENGASE	64772	broad.mit.edu	37	17	77078200	77078200	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:77078200C>G	ENST00000539857.2	+	6	950	c.535C>G	c.(535-537)Cat>Gat	p.H179D	ENGASE_ENST00000584568.1_Intron|ENGASE_ENST00000579016.1_Intron			Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	0						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			breast(2)|endometrium(4)|large_intestine(1)|lung(15)|prostate(2)|skin(1)	25						CCTGGGACCTCATTTCCTCAT	0.597000													13	67					0	0	1	0	0
NPEPPS	9520	broad.mit.edu	37	17	45668110	45668110	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:45668110G>A	ENST00000322157.4	+	10	1360	c.1123G>A	c.(1123-1125)Gaa>Aaa	p.E375K	NPEPPS_ENST00000530173.1_Missense_Mutation_p.E371K|NPEPPS_ENST00000525037.1_3'UTR|NPEPPS_ENST00000544660.1_Missense_Mutation_p.E295K	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	375					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						TTGGTTAAATGAAGGTTTTGC	0.363000													28	77					0	0	1	0	0
TMEM102	284114	broad.mit.edu	37	17	7339222	7339222	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:7339222G>A	ENST00000323206.1	+	2	305	c.32G>A	c.(31-33)tGg>tAg	p.W11*	TMEM102_ENST00000396568.1_Nonsense_Mutation_p.W11*|RP11-104H15.7_ENST00000575310.1_RNA	NM_178518.2	NP_848613.1	Q8N9M5	TM102_HUMAN	transmembrane protein 102	11					regulation of apoptosis|response to cytokine stimulus|signal transduction	cell surface|integral to membrane|intracellular	protein binding			kidney(1)|lung(3)|skin(1)	5		Prostate(122;0.173)				AGTGCCCCCTGGTggggcccg	0.672000													55	2					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16547773	16547773	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:16547773G>C	ENST00000597937.1	-	6	351	c.347C>G	c.(346-348)tCt>tGt	p.S116C	EPS15L1_ENST00000594975.1_Missense_Mutation_p.S116C|EPS15L1_ENST00000535753.2_Missense_Mutation_p.S116C|EPS15L1_ENST00000248070.6_Missense_Mutation_p.S116C|EPS15L1_ENST00000455140.2_Missense_Mutation_p.S116C	NM_001258376.1	NP_001245305.1	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	116					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						GGCCTCTGCAGAGGGCGGTGT	0.512000													32	53					0	0	1	0	0
AKAP12	9590	broad.mit.edu	37	6	151671189	151671189	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:151671189C>T	ENST00000402676.2	+	4	1903	c.1663C>T	c.(1663-1665)Ccg>Tcg	p.P555S	AKAP12_ENST00000253332.1_Missense_Mutation_p.P555S|AKAP12_ENST00000359755.5_Missense_Mutation_p.P450S|AKAP12_ENST00000354675.6_Missense_Mutation_p.P457S	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	555	Involved in PKC-binding (Probable).				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		AGCCGATTCTCCGGACAGCCA	0.557000													40	41					0	0	1	0	0
ARID4B	51742	broad.mit.edu	37	1	235345306	235345306	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:235345306C>G	ENST00000264183.3	-	20	3425	c.2928G>C	c.(2926-2928)gaG>gaC	p.E976D	ARID4B_ENST00000366603.2_Missense_Mutation_p.E976D|ARID4B_ENST00000349213.3_Missense_Mutation_p.E890D	NM_016374.5	NP_057458.4	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B (RBP1-like)	976					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			GTGAACAACTCTCCTCTTCAG	0.493000													125	44					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128492964	128492964	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:128492964C>G	ENST00000325888.8	+	37	6348	c.6087C>G	c.(6085-6087)ttC>ttG	p.F2029L	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Missense_Mutation_p.F1996L	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2029					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						ACAGCCCCTTCAAGATCCTGG	0.612000													20	98					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56093720	56093720	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr20:56093720T>A	ENST00000608158.1	-	4	1814	c.1153A>T	c.(1153-1155)Aaa>Taa	p.K385*	CTCFL_ENST00000371196.2_Intron|CTCFL_ENST00000429804.3_Intron|CTCFL_ENST00000608440.1_Intron|CTCFL_ENST00000422869.2_Intron|CTCFL_ENST00000608858.1_Intron|CTCFL_ENST00000608263.1_Intron|CTCFL_ENST00000609232.1_Intron|CTCFL_ENST00000608903.1_Intron|CTCFL_ENST00000481655.2_Nonsense_Mutation_p.K385*|CTCFL_ENST00000502686.2_Intron|CTCFL_ENST00000243914.3_Intron|CTCFL_ENST00000433949.3_Intron|CTCFL_ENST00000539382.1_Intron|CTCFL_ENST00000432255.2_Intron|CTCFL_ENST00000423479.3_Intron|CTCFL_ENST00000608425.1_Intron	NM_001269052.1	NP_001255981.1	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like						cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			AAAGCCTGTTTGTAACAGATT	0.318000													53	103					0	0	1	0	0
IP6K1	9807	broad.mit.edu	37	3	49775649	49775649	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:49775649C>G	ENST00000321599.4	-	3	731	c.430G>C	c.(430-432)Gag>Cag	p.E144Q	IP6K1_ENST00000468463.1_Missense_Mutation_p.E144Q|IP6K1_ENST00000460540.1_5'UTR|IP6K1_ENST00000395238.1_5'UTR	NM_001242829.1|NM_153273.3	NP_001229758.1|NP_695005.1	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1	144					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|skin(2)	15						TCTTACCTCTCAGAGGTCTCA	0.577000													29	30					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53668482	53668482	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:53668482G>A	ENST00000600412.1	-	2	1181	c.1066C>T	c.(1066-1068)Cga>Tga	p.R356*	ZNF665_ENST00000396424.3_Nonsense_Mutation_p.R421*			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	356					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TGAATTCTTCGATGATTTGCT	0.408000													26	63					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91715574	91715574	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:91715574C>T	ENST00000359028.2	+	37	9294	c.9069C>T	c.(9067-9069)ttC>ttT	p.F3023F	AKAP9_ENST00000356239.3_Silent_p.F3019F|AKAP9_ENST00000358100.2_Silent_p.F2969F			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3023					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ATGAGAGCTTCTCAGACTGGC	0.373000			T	BRAF	papillary thyroid								77	94					0	0	1	0	0
YAF2	10138	broad.mit.edu	37	12	42631500	42631500	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:42631500G>T	ENST00000555248.2	-	2	221	c.53C>A	c.(52-54)tCg>tAg	p.S18*	YAF2_ENST00000380788.3_5'UTR|YAF2_ENST00000327791.4_Nonsense_Mutation_p.S18*|YAF2_ENST00000541702.2_5'UTR|YAF2_ENST00000380790.4_Intron|YAF2_ENST00000442791.3_Nonsense_Mutation_p.S18*|YAF2_ENST00000534854.2_Nonsense_Mutation_p.S18*	NM_001190980.1	NP_001177909.1	Q8IY57	YAF2_HUMAN	YY1 associated factor 2	18					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|zinc ion binding			cervix(2)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)	8	all_cancers(12;0.000425)	Lung NSC(34;0.0402)|all_lung(34;0.057)		GBM - Glioblastoma multiforme(48;0.0514)		ACCCTCATCCGAGGACGGCTT	0.706000													4	8					0.00116845	0.00118611	1	1	0
SP8	221833	broad.mit.edu	37	7	20826399	20826399	+	Translation_Start_Site	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:20826399C>A	ENST00000361443.4	-	0	106				SP8_ENST00000418710.2_Missense_Mutation_p.G7W	NM_198956.2	NP_945194.1	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	8						AGACTCACCCCTAGAAGTGAA	0.453000													103	103					4.00015e-43	4.38245e-43	1	1	0
TGS1	96764	broad.mit.edu	37	8	56723511	56723511	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:56723511G>A	ENST00000260129.5	+	11	2692	c.2215G>A	c.(2215-2217)Gat>Aat	p.D739N		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	739	Sufficient for catalytic activity.				cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			TGGGATAGCAGATAAGATAGA	0.423000													27	118					0	0	1	0	0
LINS	55180	broad.mit.edu	37	15	101112167	101112167	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:101112167G>A	ENST00000314742.8	-	6	1548	c.1326C>T	c.(1324-1326)ttC>ttT	p.F442F		NM_001040616.2	NP_001035706	Q8NG48	LINES_HUMAN	lines homolog (Drosophila)	442										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(4)	21						CTTGTTCTATGAAAACCCGAG	0.443000													41	94					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10898259	10898259	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr6:10898259G>C	ENST00000283141.6	+	5	648	c.352G>C	c.(352-354)Gaa>Caa	p.E118Q	SYCP2L_ENST00000543878.1_5'UTR|RP11-637O19.3_ENST00000480294.1_3'UTR	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	118						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			TTCCTGGTTTGAAAGAACAAC	0.403000													31	29					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123480538	123480538	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:123480538G>A	ENST00000529750.1	+	12	1591	c.1264G>A	c.(1264-1266)Gga>Aga	p.G422R	GRAMD1B_ENST00000450171.2_Missense_Mutation_p.G113R|GRAMD1B_ENST00000322282.7_Missense_Mutation_p.G422R|GRAMD1B_ENST00000456860.2_Missense_Mutation_p.G429R	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	422						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		GGAGGAGAATGGAAACCAGAG	0.532000													8	9					0	0	1	0	0
PML	5371	broad.mit.edu	37	15	74336951	74336951	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:74336951C>T	ENST00000565898.1	+	8	2191	c.2107C>T	c.(2107-2109)Cgt>Tgt	p.R703C	PML_ENST00000268058.3_Missense_Mutation_p.R751C			P29590	PML_HUMAN	promyelocytic leukemia	751					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						GCTGGCCATGCGTGACCTGTG	0.662000			T	"""RARA, PAX5"""	"""APL, ALL"""								39	65					0	0	1	0	0
TRIM22	10346	broad.mit.edu	37	11	5730819	5730819	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:5730819C>T	ENST00000379965.3	+	8	1715	c.1438C>T	c.(1438-1440)Ccg>Tcg	p.P480S	TRIM5_ENST00000380027.1_Intron	NM_001199573.1|NM_006074.4	NP_001186502.1|NP_006065.2	Q8IYM9	TRI22_HUMAN	tripartite motif containing 22	480	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			kidney(3)|large_intestine(8)|lung(9)|prostate(1)|stomach(2)	23		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		ACCTGCTTATCCGTATTTCAA	0.483000													90	96					0	0	1	0	0
ZNF319	57567	broad.mit.edu	37	16	58031152	58031152	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:58031152C>T	ENST00000299237.2	-	2	1640	c.1018G>A	c.(1018-1020)Gag>Aag	p.E340K		NM_020807.1	NP_065858.1	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8						AAGGGCCGCTCGGCGCTGTGT	0.667000													33	38					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62325658	62325658	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:62325658G>A	ENST00000261517.5	-	5	440	c.367C>T	c.(367-369)Caa>Taa	p.Q123*	VPS13C_ENST00000395896.4_Nonsense_Mutation_p.Q123*|VPS13C_ENST00000249837.3_Nonsense_Mutation_p.Q123*|VPS13C_ENST00000395898.3_Nonsense_Mutation_p.Q123*	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	123					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						GCTGCTTTTTGAAGGGCTTCT	0.294000													17	8					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54327641	54327641	+	Missense_Mutation	SNP	A	A	G	rs34296513		TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:54327641A>G	ENST00000306888.2	-	9	1975	c.1724T>C	c.(1723-1725)aTt>aCt	p.I575T	LNX1_ENST00000263925.7_Missense_Mutation_p.I671T|FIP1L1_ENST00000507166.1_Intron	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	671	PDZ 3.					cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TCCTTCAACAATGGATTTGAT	0.328000													9	24					0	0	1	0	0
MKRN1	23608	broad.mit.edu	37	7	140154322	140154322	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:140154322G>T	ENST00000255977.2	-	8	1668	c.1444C>A	c.(1444-1446)Cta>Ata	p.L482I	MKRN1_ENST00000437223.2_Missense_Mutation_p.L216I|MKRN1_ENST00000474576.1_Missense_Mutation_p.L418I	NM_013446.3	NP_038474.2	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1	482							ligase activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	16	Melanoma(164;0.00956)					GGTTGCTATAGATCCAAGTCA	0.522000													16	21					2.23348e-06	2.292e-06	1	1	0
ARID3A	1820	broad.mit.edu	37	19	971892	971892	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr19:971892C>T	ENST00000263620.3	+	9	1936	c.1609C>T	c.(1609-1611)Cag>Tag	p.Q537*		NM_005224.2	NP_005215.1	Q99856	ARI3A_HUMAN	AT rich interactive domain 3A (BRIGHT-like)	537	Important for cytoplasmic localization (By similarity).|REKLES.					cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(1)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGTTTGCTCAGCCGCCGGC	0.637000													58	120					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3675379	3675379	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr20:3675379G>C	ENST00000344754.4	-	11	2874	c.2875C>G	c.(2875-2877)Cat>Gat	p.H959D	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.H959D	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	959	Ig-like C2-type 9.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GCTTGGCAATGATAGGCCCCA	0.607000													71	41					0	0	1	0	0
CEP135	9662	broad.mit.edu	37	4	56883976	56883976	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:56883976G>C	ENST00000257287.4	+	22	3089	c.2965G>C	c.(2965-2967)Gat>Cat	p.D989H		NM_025009.4	NP_079285.2	Q66GS9	CP135_HUMAN	centrosomal protein 135kDa	989					centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(26)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	50	Glioma(25;0.08)|all_neural(26;0.101)					TTCAGGCAAAGATATTATGAC	0.343000													16	23					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873094	36873094	+	Silent	SNP	G	G	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:36873094G>T	ENST00000429976.2	-	21	8095	c.7848C>A	c.(7846-7848)gtC>gtA	p.V2616V	TRANK1_ENST00000428977.2_Silent_p.V2066V|TRANK1_ENST00000301807.6_Silent_p.V2066V	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2616					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AGAGGCCACGGACTATGGACC	0.547000													4	29					0.00909568	0.00913455	1	1	0
FAM21B	55747	broad.mit.edu	37	10	47909770	47909770	+	Silent	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:47909770C>T	ENST00000358474.5	+	11	867	c.867C>T	c.(865-867)ctC>ctT	p.L289L		NM_018232.1	NP_060702.1	Q5SNT6	FA21B_HUMAN	family with sequence similarity 21, member B	289					retrograde transport, endosome to Golgi	early endosome membrane|WASH complex				endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	10						AGAGTGACCTCTTCACGGAAG	0.483000													51	1					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182847159	182847159	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:182847159G>C	ENST00000367549.3	+	20	2312	c.2202G>C	c.(2200-2202)caG>caC	p.Q734H	DHX9_ENST00000485081.1_3'UTR	NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	734	Helicase C-terminal.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						TATGTAGGCAGAAAGTGAAAC	0.388000													9	48					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36699972	36699972	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr13:36699972C>A	ENST00000255448.4	-	2	514	c.303G>T	c.(301-303)ttG>ttT	p.L101F	DCLK1_ENST00000379892.4_Missense_Mutation_p.L101F|DCLK1_ENST00000360631.3_Missense_Mutation_p.L101F	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	101	Doublecortin 1.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CTCCCTGGGGCAAATTCACGT	0.522000													58	47					3.28156e-27	3.55376e-27	1	1	0
BAGE2	85319	broad.mit.edu	37	21	11058353	11058353	+	RNA	SNP	T	T	C	rs79433933	by1000genomes	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr21:11058353T>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAAATCTCTTTATAAAACCTT	0.343000													5	121					0	0	1	0	0
GPR176	11245	broad.mit.edu	37	15	40212135	40212135	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr15:40212135G>A	ENST00000299092.3	-	1	291	c.93C>T	c.(91-93)ctC>ctT	p.L31L	GPR176_ENST00000561100.1_Silent_p.L31L	NM_001271854.1|NM_001271855.1	NP_001258783.1|NP_001258784.1	Q14439	GP176_HUMAN	G protein-coupled receptor 176	31					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)	23		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		CGAACTCCCCGAGCGCGCTGC	0.682000													16	3					0	0	1	0	0
GABRA6	2559	broad.mit.edu	37	5	161128759	161128759	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:161128759G>C	ENST00000523217.1	+	9	1554	c.1312G>C	c.(1312-1314)Gtc>Ctc	p.V438L	GABRA6_ENST00000274545.5_Missense_Mutation_p.V448L	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	448					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TACAATGGAAGTCAGTAGCAG	0.373000										TCGA Ovarian(5;0.080)			13	58					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158645975	158645975	+	Silent	SNP	A	A	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr1:158645975A>T	ENST00000368147.4	-	8	1248	c.1068T>A	c.(1066-1068)cgT>cgA	p.R356R		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TGGCCAGGGCACGAATATGCT	0.478000													144	46					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	123993774	123993774	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:123993774G>A	ENST00000456829.2	+	8	1119	c.868G>A	c.(868-870)Gga>Aga	p.G290R	VWA5A_ENST00000392744.4_Missense_Mutation_p.G306R|VWA5A_ENST00000449321.1_Missense_Mutation_p.G290R|VWA5A_ENST00000392748.1_Missense_Mutation_p.G290R|VWA5A_ENST00000360334.4_Missense_Mutation_p.G290R|VWA5A_ENST00000361352.5_Missense_Mutation_p.G290R	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	290	VWFA.									autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						GGACCGCTCGGGAAGTATGCA	0.473000													20	28					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176022548	176022548	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:176022548C>T	ENST00000510636.1	+	32	4082	c.3808C>T	c.(3808-3810)Cac>Tac	p.H1270Y	CDHR2_ENST00000506348.1_Missense_Mutation_p.H1270Y|CDHR2_ENST00000261944.5_Missense_Mutation_p.H1270Y	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	1270					homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CAGGCCACCACACACACCACC	0.652000													81	115					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75179794	75179794	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:75179794C>T	ENST00000338772.5	-	1	6	c.7G>A	c.(7-9)Ggg>Agg	p.G3R	AREL1_ENST00000557401.1_5'UTR|AREL1_ENST00000356357.4_5'UTR																							GCCCTTTCCCCAAGGAGTTTC	0.587000													23	29					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67219297	67219297	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:67219297G>A	ENST00000312457.2	-	1	903	c.899C>T	c.(898-900)gCc>gTc	p.A300V		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	300						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CCGGAGGTCGGCACTGGCCAT	0.657000													4	121					0	0	1	0	0
TMEM105	284186	broad.mit.edu	37	17	79287602	79287602	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:79287602C>T	ENST00000332900.1	-	3	788	c.239G>A	c.(238-240)aGa>aAa	p.R80K		NM_178520.3	NP_848615.1	Q8N8V8	TM105_HUMAN	transmembrane protein 105	80						integral to membrane				NS(1)|large_intestine(3)|lung(1)|ovary(2)	7	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.0892)			TCTTCGCCTTCTTATCTTCAT	0.662000													134	68					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32048697	32048697	+	Silent	SNP	G	G	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:32048697G>A	ENST00000438447.1	+	8	1960	c.1572G>A	c.(1570-1572)cgG>cgA	p.R524R	PDZD2_ENST00000282493.3_Silent_p.R524R			O15018	PDZD2_HUMAN	PDZ domain containing 2	524					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						TGATGGTGCGGAATGGGGACC	0.537000													27	27					0	0	1	0	0
RAB6A	5870	broad.mit.edu	37	11	73429730	73429730	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr11:73429730C>T	ENST00000336083.3	-	4	672	c.217G>A	c.(217-219)Gag>Aag	p.E73K	RAB6A_ENST00000536566.1_Intron|RAB6A_ENST00000310653.6_Intron|RAB6A_ENST00000541588.1_Intron	NM_198896.1	NP_942599.1	P20340	RAB6A_HUMAN	RAB6A, member RAS oncogene family	73					minus-end-directed organelle transport along microtubule|peptidyl-cysteine methylation|protein targeting to Golgi|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic vesicle|cytosol|Golgi membrane|trans-Golgi network	GTP binding|GTPase activity|protein domain specific binding			large_intestine(2)|lung(2)	4						CTGAACCGCTCTTGACCTGCT	0.408000													28	33					0	0	1	0	0
KANSL1L	151050	broad.mit.edu	37	2	210940388	210940388	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:210940388A>G	ENST00000281772.9	-	6	1906	c.1643T>C	c.(1642-1644)cTg>cCg	p.L548P	KANSL1L_ENST00000457374.1_Missense_Mutation_p.L548P|KANSL1L_ENST00000418791.1_Missense_Mutation_p.L548P|KANSL1L_ENST00000452086.1_Missense_Mutation_p.L548P	NM_152519.2	NP_689732.2	A0AUZ9	CB067_HUMAN	KAT8 regulatory NSL complex subunit 1-like	548																	TGAAGATTTCAGTCTTGTCCT	0.408000													25	21					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31138232	31138232	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr10:31138232C>G	ENST00000452305.1	-	8	1635	c.1072G>C	c.(1072-1074)Gat>Cat	p.D358H	ZNF438_ENST00000361310.3_Missense_Mutation_p.D368H|ZNF438_ENST00000442986.1_Missense_Mutation_p.D368H|ZNF438_ENST00000538351.2_Missense_Mutation_p.D319H|ZNF438_ENST00000331737.6_Missense_Mutation_p.D358H|ZNF438_ENST00000413025.1_Missense_Mutation_p.D368H|ZNF438_ENST00000436087.2_Missense_Mutation_p.D368H|ZNF438_ENST00000375311.1_5'UTR|ZNF438_ENST00000444692.2_Missense_Mutation_p.D358H	NM_001143770.1	NP_001137242.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	368					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				TGGTTAAGATCAAGTTTGGTG	0.458000													33	36					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67132309	67132309	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:67132309G>C	ENST00000284425.2	-	4	558	c.384C>G	c.(382-384)atC>atG	p.I128M	ABCA6_ENST00000590645.1_Missense_Mutation_p.I128M	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	128					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					TTTCATTAAAGATGATTCCCA	0.333000													22	10					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104748140	104748140	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:104748140C>G	ENST00000334877.4	+	22	3770	c.3236C>G	c.(3235-3237)tCa>tGa	p.S1079*	KMT2E_ENST00000334914.7_Nonsense_Mutation_p.S134*|KMT2E_ENST00000257745.4_Nonsense_Mutation_p.S1079*|KMT2E_ENST00000311117.3_Nonsense_Mutation_p.S1079*					lysine (K)-specific methyltransferase 2E																		GTTAACTTCTCAGTGAACTCC	0.522000													34	24					0	0	1	0	0
NANOG	79923	broad.mit.edu	37	12	7945633	7945633	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:7945633C>T	ENST00000229307.4	+	2	458	c.239C>T	c.(238-240)gCa>gTa	p.A80V	NANOG_ENST00000526286.1_Missense_Mutation_p.A80V	NM_024865.2	NP_079141.2	Q9H9S0	NANOG_HUMAN	Nanog homeobox	80					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14				Kidney(36;0.0872)		CCCACTTCTGCAGAGAAGAGT	0.483000													34	76					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238283106	238283106	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr2:238283106delG	ENST00000295550.4	-	8	4080	c.3628delC	c.(3628-3630)cgcfs	p.R1210fs	COL6A3_ENST00000346358.4_Frame_Shift_Del_p.R1010fs|COL6A3_ENST00000347401.3_Frame_Shift_Del_p.R1009fs|COL6A3_ENST00000392004.3_Frame_Shift_Del_p.R1004fs|COL6A3_ENST00000409809.1_Frame_Shift_Del_p.R1004fs|COL6A3_ENST00000472056.1_Frame_Shift_Del_p.R603fs|COL6A3_ENST00000392003.2_Frame_Shift_Del_p.R803fs|COL6A3_ENST00000353578.4_Frame_Shift_Del_p.R1004fs	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1210	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGCTCCTCGCGGGTGAGCTGG	0.612													43	59	---	---	---	---					
ACAA1	30	broad.mit.edu	37	3	38175473	38175474	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr3:38175473_38175474insC	ENST00000333167.8	-	3	464_465	c.292_293insG	c.(292-294)gcafs	p.A98fs	ACAA1_ENST00000444607.2_Frame_Shift_Ins_p.A98fs|ACAA1_ENST00000544624.1_5'UTR|ACAA1_ENST00000450296.1_Frame_Shift_Ins_p.A98fs|ACAA1_ENST00000301810.7_Frame_Shift_Ins_p.A98fs	NM_001607.3	NP_001598.1	P09110	THIK_HUMAN	acetyl-CoA acyltransferase 1	98					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy	peroxisomal matrix	acetyl-CoA C-acyltransferase activity|protein binding			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0523)|Kidney(284;0.0657)		GGCCATGATTGCCCCGGCCCCA	0.520													32	37	---	---	---	---					
FRG1	2483	broad.mit.edu	37	4	190878555	190878556	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr4:190878555_190878556insA	ENST00000226798.4	+	6	657_658	c.435_436insA	c.(436-438)aaafs	p.K146fs	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	146					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		TCACTTAGGGGAAAATGGCTTT	0.351													7	33	---	---	---	---					
C1QTNF2	114898	broad.mit.edu	37	5	159776644	159776644	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr5:159776644delC	ENST00000393975.3	-	3	527	c.524delG	c.(523-525)ggcfs	p.G175fs		NM_031908.4	NP_114114.2	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	130	C1q.					collagen				breast(2)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	13	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCCTTCTTGCCCTTGGGCCC	0.682													86	141	---	---	---	---					
PHTF2	57157	broad.mit.edu	37	7	77539666	77539690	+	Frame_Shift_Del	DEL	CCTCTCACAGCGTTGGCACTGTCTT	CCTCTCACAGCGTTGGCACTGTCTT	-	rs12673343	by1000genomes	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr7:77539666_77539690delCCTCTCACAGCGTTGGCACTGTCTT	ENST00000416283.2	+	7	740_764	c.614_638delCCTCTCACAGCGTTGGCACTGTCTT	c.(613-639)acctctcacagcgttggcactgtcttcfs	p.TSHSVGTVF205fs	PHTF2_ENST00000248550.7_Frame_Shift_Del_p.TSHSVGTVF239fs|PHTF2_ENST00000454592.1_3'UTR|PHTF2_ENST00000450574.1_Frame_Shift_Del_p.TSHSVGTVF205fs|PHTF2_ENST00000275575.7_Frame_Shift_Del_p.TSHSVGTVF201fs|PHTF2_ENST00000422959.2_Frame_Shift_Del_p.TSHSVGTVF205fs|PHTF2_ENST00000307305.8_Frame_Shift_Del_p.TSHSVGTVF201fs|PHTF2_ENST00000424760.1_Frame_Shift_Del_p.TSHSVGTVF201fs|PHTF2_ENST00000415251.2_Frame_Shift_Del_p.TSHSVGTVF201fs	NM_001127357.1|NM_020432.4	NP_001120829.1|NP_065165.3	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	239					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	19						GGTACAAGCACCTCTCACAGCGTTGGCACTGTCTTCAGAGATCTC	0.431													7	53	---	---	---	---					
LINC00051	619434	broad.mit.edu	37	8	143287465	143287466	+	RNA	INS	-	-	AGGGGC			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr8:143287465_143287466insAGGGGC	ENST00000517704.1	+	0	101					NR_024378.1																						GAGACAGCGGAaggggcagggg	0.624													3	3	---	---	---	---					
PKN3	29941	broad.mit.edu	37	9	131467798	131467799	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr9:131467798_131467799delCC	ENST00000291906.4	+	2	634_635	c.241_242delCC	c.(241-243)cccfs	p.P81fs		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	81					signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						AATCCTGCTGCCCGGCCCTGGG	0.703													2	4	---	---	---	---					
NCS1	23413	broad.mit.edu	37	9	132934960	132934960	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr9:132934960delC	ENST00000372398.3	+	1	104	c.18delC	c.(16-18)agcfs	p.S6fs		NM_014286.3	NP_055101.2	P62166	NCS1_HUMAN	neuronal calcium sensor 1	6					negative regulation of calcium ion transport via voltage-gated calcium channel activity|regulation of neuron projection development	cell junction|Golgi cisterna membrane|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|protein binding			large_intestine(1)|lung(4)|stomach(1)	6						AATCCAACAGCAAGTTGAAGC	0.751													2	4	---	---	---	---					
DNM1L	10059	broad.mit.edu	37	12	32861134	32861135	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr12:32861134_32861135delAG	ENST00000452533.2	+	4	509_510	c.345_346delAG	c.(343-348)acagaafs	p.E116fs	DNM1L_ENST00000414834.2_Intron|DNM1L_ENST00000547312.1_Frame_Shift_Del_p.E116fs|DNM1L_ENST00000548671.1_3'UTR|DNM1L_ENST00000358214.5_Frame_Shift_Del_p.E129fs|DNM1L_ENST00000266481.6_Frame_Shift_Del_p.E116fs|DNM1L_ENST00000553257.1_Frame_Shift_Del_p.E129fs|DNM1L_ENST00000549701.1_Frame_Shift_Del_p.E116fs|DNM1L_ENST00000381000.4_Frame_Shift_Del_p.E129fs	NM_012062.3|NM_012063.2	NP_036192.2|NP_036193.2	O00429	DNM1L_HUMAN	dynamin 1-like	116	GTPase domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	23	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AAAATGAAACAGAAAGAATTTC	0.262													14	19	---	---	---	---					
OR4N2	390429	broad.mit.edu	37	14	20295841	20295842	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:20295841_20295842insC	ENST00000315947.1	+	1	234_235	c.234_235insC	c.(235-237)cccfs	p.P79fs	OR4N2_ENST00000568211.1_Frame_Shift_Ins_p.P79fs	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	79					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCATTGTGGCTCCCCGGATGTT	0.515													104	293	---	---	---	---					
HSP90AA1	3320	broad.mit.edu	37	14	102550760	102550761	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr14:102550760_102550761delCA	ENST00000334701.7	-	7	1769_1770	c.1488_1489delTG	c.(1486-1491)tgtgagfs	p.CE496fs	HSP90AA1_ENST00000216281.8_Frame_Shift_Del_p.CE374fs|HSP90AA1_ENST00000441629.2_Frame_Shift_Del_p.CE195fs	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	374					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	ATTAGCTCCTCACAGTTATCCA	0.386													38	51	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81253526	81253527	+	RNA	INS	-	-	TTATT	rs140827348	by1000genomes	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr16:81253526_81253527insTTATT	ENST00000337114.4	-	0	301				PKD1L2_ENST00000525539.1_RNA	NM_001076780.1	NP_001070248.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						ttagacatgaattatttaatcc	0.391													3	5	---	---	---	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	In_Frame_Del	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	rs483929	by1000genomes	TCGA-FD-A43X-01A-11D-A23U-08	TCGA-FD-A43X-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8daf852a-d4c8-4075-90fa-9a79c22e59c3	6ecb3798-2d62-4ba3-9613-4bfe656bfe02	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	ENST00000398472.1	-	1	742_798	c.255_311delCCCACTCTGCTGTCAGACCACCTGCCACCCCAGCTGTGGTATGTCCAGCTGCTGCCG	c.(253-312)cgcccactctgctgtcagaccacctgccaccccagctgtggtatgtccagctgctgccgt>cgt	p.85_104RPLCCQTTCHPSCGMSSCCR>R				Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	85	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].		Missing (in allele KAP4.10).			keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													8	197	---	---	---	---					
