Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
STK32B	55351	broad.mit.edu	37	4	5141659	5141659	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:5141659G>A	ENST00000282908.5	+	2	502	c.80G>A	c.(79-81)cGg>cAg	p.R27Q	STK32B_ENST00000512636.1_5'UTR|STK32B_ENST00000510398.1_5'UTR	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	27	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						CAGATTCTGCGGGCCATTGGT	0.388000													26	103					0	0	1	0	0
TCP11L1	55346	broad.mit.edu	37	11	33079495	33079495	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:33079495A>G	ENST00000334274.4	+	5	848	c.448A>G	c.(448-450)Act>Gct	p.T150A	TCP11L1_ENST00000432887.1_Missense_Mutation_p.T150A|TCP11L1_ENST00000531632.2_Missense_Mutation_p.T150A|TCP11L1_ENST00000530171.1_3'UTR	NM_018393.3	NP_060863.3	Q9NUJ3	T11L1_HUMAN	t-complex 11, testis-specific-like 1	150										kidney(1)|liver(2)|lung(2)|skin(1)	6						GCCTGGTCATACTAGACTGAG	0.373000													5	35					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73152209	73152209	+	Missense_Mutation	SNP	G	G	A	rs146119682	byFrequency	TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr9:73152209G>A	ENST00000377110.3	-	25	4027	c.3784C>T	c.(3784-3786)Cgc>Tgc	p.R1262C	TRPM3_ENST00000396280.5_Missense_Mutation_p.R1111C|TRPM3_ENST00000396285.1_Missense_Mutation_p.R1121C|TRPM3_ENST00000377105.1_Missense_Mutation_p.R1121C|TRPM3_ENST00000423814.3_Missense_Mutation_p.R1289C|TRPM3_ENST00000360823.2_Missense_Mutation_p.R1124C|TRPM3_ENST00000396292.4_Missense_Mutation_p.R1134C|TRPM3_ENST00000358082.3_Missense_Mutation_p.R1124C|TRPM3_ENST00000377111.2_Missense_Mutation_p.R1262C|TRPM3_ENST00000357533.2_Missense_Mutation_p.R1266C|TRPM3_ENST00000377106.1_Missense_Mutation_p.R1134C|TRPM3_ENST00000408909.2_Missense_Mutation_p.R1121C			Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3							integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GTGGCCATGCGCCCGATAAGG	0.627000													11	59					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23894224	23894224	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr14:23894224C>T	ENST00000355349.3	-	22	2595	c.2433G>A	c.(2431-2433)ctG>ctA	p.L811L		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	811					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GGATTACCAGCAGGGAGTCTC	0.532000													9	69					0	0	1	0	0
RPS12	6206	broad.mit.edu	37	6	133138189	133138189	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr6:133138189G>T	ENST00000230050.3	+	5	535	c.325G>T	c.(325-327)Gta>Tta	p.V109L		NM_001016.3	NP_001007.2	P25398	RS12_HUMAN	ribosomal protein S12	109					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	structural constituent of ribosome			endometrium(1)|kidney(13)|lung(3)|urinary_tract(1)	18	Breast(56;0.214)			OV - Ovarian serous cystadenocarcinoma(155;0.00284)|GBM - Glioblastoma multiforme(226;0.0256)		TTGCAGTTGTGTAGTAGTTAA	0.393000													8	42					0.0477658	0.0477658	1	1	0
TBR1	10716	broad.mit.edu	37	2	162273338	162273338	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:162273338C>T	ENST00000389554.3	+	1	734	c.417C>T	c.(415-417)atC>atT	p.I139I		NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	139						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						CCTTCTCCATCGGCAGCCCTA	0.677000													25	219					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32036209	32036209	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr6:32036209C>T	ENST00000375244.3	-	17	6379	c.6178G>A	c.(6178-6180)Ggt>Agt	p.G2060S	TNXB_ENST00000375247.2_Missense_Mutation_p.G2060S			P22105	TENX_HUMAN	tenascin XB	2142					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CGCTGGCCACCGTGGAAGCCG	0.632000													4	50					0	0	1	0	0
RUFY3	22902	broad.mit.edu	37	4	71634361	71634361	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:71634361G>C	ENST00000226328.4	+	5	1242	c.679G>C	c.(679-681)Gaa>Caa	p.E227Q	RUFY3_ENST00000536664.1_Missense_Mutation_p.E211Q|RUFY3_ENST00000417478.2_Missense_Mutation_p.E287Q|RUFY3_ENST00000502653.1_Missense_Mutation_p.E174Q|RUFY3_ENST00000381006.3_Missense_Mutation_p.E227Q	NM_014961.3	NP_055776.1	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3	227	RUN.				negative regulation of axonogenesis	filopodium|growth cone				endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)	16		all_hematologic(202;0.248)	Lung(101;0.235)			TATGAAAGGAGAAGACTTGGA	0.448000													28	82					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7401030	7401030	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:7401030G>T	ENST00000322644.6	+	7	1442	c.1043G>T	c.(1042-1044)gGc>gTc	p.G348V	POLR2A_ENST00000572844.1_Missense_Mutation_p.G348V	NM_000937.4	NP_000928	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	348					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				GGCAAGGAAGGCCGGGTGCGA	0.602000													7	65					0.00198382	0.00200882	1	1	0
CDH26	60437	broad.mit.edu	37	20	58569409	58569409	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr20:58569409G>C	ENST00000348616.4	+	11	1831	c.1531G>C	c.(1531-1533)Gag>Cag	p.E511Q	CDH26_ENST00000497614.1_3'UTR|CDH26_ENST00000244047.5_Missense_Mutation_p.E511Q	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	511					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GGAGGTCTGTGAGTCTGCTGT	0.557000													11	76					0	0	1	0	0
CEBPE	1053	broad.mit.edu	37	14	23586911	23586911	+	Silent	SNP	G	G	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr14:23586911G>T	ENST00000206513.5	-	2	1155	c.631C>A	c.(631-633)Cgg>Agg	p.R211R		NM_001805.3	NP_001796.2	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein (C/EBP), epsilon	211						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)	9	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		TTGCGCTCCCGCCTCAGCCGG	0.617000													34	66					9.65963e-10	1.03008e-09	1	1	0
HOXB8	3218	broad.mit.edu	37	17	46691976	46691976	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:46691976C>T	ENST00000239144.4	-	1	325	c.91G>A	c.(91-93)Gac>Aac	p.D31N	HOXB8_ENST00000576562.1_Missense_Mutation_p.D31N|HOXB7_ENST00000567101.2_Intron	NM_024016.3	NP_076921.1	P17481	HXB8_HUMAN	homeobox B8	31						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.A29_D31delAQD(1)		large_intestine(1)|lung(8)|urinary_tract(2)	11						CCGCCCAGGTCCTGGGCGAAG	0.577000													4	22					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17032461	17032461	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr10:17032461G>T	ENST00000377833.4	-	29	4287	c.4222C>A	c.(4222-4224)Ccc>Acc	p.P1408T		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1408	CUB 9.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TACCTGTTGGGGAACCCGGGG	0.527000													10	90					0.000673444	0.000690638	1	1	0
IKBKB	3551	broad.mit.edu	37	8	42162785	42162785	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr8:42162785G>A	ENST00000520810.1	+	6	655	c.469G>A	c.(469-471)Gaa>Aaa	p.E157K	IKBKB_ENST00000522147.1_Intron|IKBKB_ENST00000520835.1_Missense_Mutation_p.E155K|IKBKB_ENST00000416505.2_Missense_Mutation_p.E98K|IKBKB_ENST00000519735.1_Missense_Mutation_p.E157K|IKBKB_ENST00000379708.3_Intron	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	157	Protein kinase.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GCAGCAAGGAGAACAGAGGGT	0.537000													5	46					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23906234	23906234	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr13:23906234C>T	ENST00000382298.3	-	10	12369	c.11781G>A	c.(11779-11781)gcG>gcA	p.A3927A	SACS_ENST00000402364.1_Silent_p.A3177A|SACS_ENST00000382292.3_Silent_p.A3927A	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3927					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TATAATGTGGCGCATCGTCAA	0.443000													38	149					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55595021	55595021	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:55595021C>T	ENST00000378397.1	+	1	327	c.327C>T	c.(325-327)gtC>gtT	p.V109V		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				CATGTGGAGTCACTGAGGTCT	0.493000										HNSCC(27;0.073)			25	1553					0	0	1	0	0
ZZZ3	26009	broad.mit.edu	37	1	78098097	78098097	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:78098097C>T	ENST00000370801.3	-	5	1418	c.943G>A	c.(943-945)Gag>Aag	p.E315K	ZZZ3_ENST00000476275.1_5'UTR|ZZZ3_ENST00000370798.1_Intron	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	315					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						ACTTCCTCCTCAGAATCCCTT	0.458000													10	112					0	0	1	0	0
HOXA1	3198	broad.mit.edu	37	7	27135134	27135134	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr7:27135134C>T	ENST00000343060.4	-	1	459	c.398G>A	c.(397-399)gGa>gAa	p.G133E	HOXA1_ENST00000355633.5_Intron	NM_005522.4	NP_005513	P49639	HXA1_HUMAN	homeobox A1	133						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.G133E(1)		endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TGAGAGATTTCCAGAGTAAAC	0.567000													11	127					0	0	1	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99627511	99627511	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr7:99627511C>T	ENST00000324306.6	+	4	842	c.608C>T	c.(607-609)cCc>cTc	p.P203L	ZKSCAN1_ENST00000535170.1_5'UTR|ZKSCAN1_ENST00000426572.1_Missense_Mutation_p.P167L	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	203					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			ATTCCTGCACCCCCTCATGAG	0.592000													23	107					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66462691	66462691	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr5:66462691G>C	ENST00000404260.3	+	29	8001	c.7693G>C	c.(7693-7695)Ggg>Cgg	p.G2565R	MAST4_ENST00000261569.7_Missense_Mutation_p.G2368R|MAST4_ENST00000405643.1_Missense_Mutation_p.G2383R|MAST4_ENST00000403625.2_Missense_Mutation_p.G2562R|MAST4_ENST00000403666.1_Missense_Mutation_p.G2373R			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	2565						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GGAAACCAAAGGGAAGGACCC	0.657000													3	16					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123813621	123813621	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:123813621T>C	ENST00000321252.2	-	1	959	c.925A>G	c.(925-927)Agg>Ggg	p.R309G		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GCAGTGAGCCTGGGCCACCCC	0.443000													4	137					0	0	1	0	0
DDAH1	23576	broad.mit.edu	37	1	85787233	85787233	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:85787233C>A	ENST00000284031.8	-	6	854	c.760G>T	c.(760-762)Gac>Tac	p.D254Y	DDAH1_ENST00000539042.1_Missense_Mutation_p.D254Y|RP11-131L23.1_ENST00000426125.1_RNA|DDAH1_ENST00000483110.1_5'UTR|DDAH1_ENST00000426972.3_Missense_Mutation_p.D161Y|RP11-131L23.1_ENST00000427819.1_RNA|DDAH1_ENST00000542148.1_Missense_Mutation_p.D154Y|DDAH1_ENST00000535924.2_Missense_Mutation_p.D151Y	NM_012137.3	NP_036269.1	O94760	DDAH1_HUMAN	dimethylarginine dimethylaminohydrolase 1	254					arginine catabolic process|citrulline metabolic process|nitric oxide mediated signal transduction		dimethylargininase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|skin(1)	5				all cancers(265;0.0318)|Epithelial(280;0.0657)	L-Citrulline(DB00155)	AGCATATGGTCCTTCAGTTTC	0.418000													9	61					1.12685e-05	1.17056e-05	1	1	0
RUFY2	55680	broad.mit.edu	37	10	70156625	70156625	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr10:70156625G>A	ENST00000388768.2	-	4	741	c.415C>T	c.(415-417)Cga>Tga	p.R139*	RUFY2_ENST00000342616.4_Nonsense_Mutation_p.R104*|RUFY2_ENST00000602465.1_Nonsense_Mutation_p.R104*|RUFY2_ENST00000472394.2_5'UTR|RUFY2_ENST00000399200.2_Intron|RUFY2_ENST00000454950.2_Nonsense_Mutation_p.R46*	NM_017987.4	NP_060457.4	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain containing 2	153	RUN.					nucleus	metal ion binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)	20						GCTCTTGCTCGACCCAGAGGG	0.418000													11	34					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213914560	213914560	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:213914560G>A	ENST00000457361.1	-	5	619	c.451C>T	c.(451-453)Cag>Tag	p.Q151*	IKZF2_ENST00000342002.2_Nonsense_Mutation_p.Q157*|IKZF2_ENST00000374319.4_Nonsense_Mutation_p.Q125*|IKZF2_ENST00000413091.3_Nonsense_Mutation_p.Q151*|IKZF2_ENST00000434687.1_Nonsense_Mutation_p.Q151*|IKZF2_ENST00000374327.4_Intron|IKZF2_ENST00000421754.2_Nonsense_Mutation_p.Q125*|IKZF2_ENST00000451136.2_Nonsense_Mutation_p.Q125*	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		TTGCCCTTCTGAGTAAAAGAA	0.473000													6	20					0	0	1	0	0
IRX6	79190	broad.mit.edu	37	16	55362903	55362903	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr16:55362903G>A	ENST00000290552.7	+	5	2345	c.1013G>A	c.(1012-1014)aGg>aAg	p.R338K	RP11-26L20.3_ENST00000558730.2_RNA	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	338						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R338M(1)		breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						GGCAGCCCTAGGTTGACCATG	0.647000													9	56					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102269957	102269957	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:102269957G>A	ENST00000370103.4	-	6	1427	c.1214C>T	c.(1213-1215)tCc>tTc	p.S405F	OLFM3_ENST00000338858.5_Missense_Mutation_p.S425F|OLFM3_ENST00000536598.1_3'UTR|OLFM3_ENST00000462354.1_5'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	425	Olfactomedin-like.					extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CTCATATGTGGAGGTTTTGGT	0.433000													28	184					0	0	1	0	0
COBLL1	22837	broad.mit.edu	37	2	165584636	165584636	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:165584636C>T	ENST00000375458.2	-	4	725	c.504G>A	c.(502-504)tcG>tcA	p.S168S	COBLL1_ENST00000342193.4_Silent_p.S168S|COBLL1_ENST00000392717.2_Silent_p.S206S|COBLL1_ENST00000194871.6_Silent_p.S221S|COBLL1_ENST00000491126.2_Intron|COBLL1_ENST00000409184.3_Silent_p.S206S	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	206										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						GCTCTTGAAGCGATGCATGTG	0.378000													7	75					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15688989	15688989	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr10:15688989T>C	ENST00000378076.3	-	12	1416	c.1063A>G	c.(1063-1065)Aga>Gga	p.R355G		NM_003638.1	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8	355					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CCTACTTCTCTGGGGTTGCTC	0.507000													13	57					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													4	61					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49940823	49940823	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr3:49940823T>C	ENST00000296474.3	-	1	247	c.220A>G	c.(220-222)Ata>Gta	p.I74V	CTD-2330K9.2_ENST00000435478.1_RNA|MST1R_ENST00000344206.4_Missense_Mutation_p.I74V	NM_002447.2	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	74	Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CGATTGCGTATGGCTACAAAC	0.617000													14	117					0	0	1	0	0
C16orf82	162083	broad.mit.edu	37	16	27078340	27078340	+	RNA	SNP	C	C	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr16:27078340C>A	ENST00000505035.1	+	0	313				RP11-673P17.2_ENST00000565783.1_RNA			Q7Z2V1	TNT_HUMAN																			TTCAGCTGCCCCCCATTTTTC	0.567000													18	55					6.94344e-10	7.4372e-10	1	1	0
CACNA1B	774	broad.mit.edu	37	9	140911629	140911629	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr9:140911629C>G	ENST00000277550.3	+	3	179	c.179C>G	c.(178-180)tCa>tGa	p.S60*	CACNA1B_ENST00000371363.1_Intron|CACNA1B_ENST00000371355.4_Intron|CACNA1B_ENST00000371372.1_Intron|CACNA1B_ENST00000277549.5_Intron|CACNA1B_ENST00000371357.1_Intron|CACNA1B_ENST00000277551.2_Intron			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	0					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity	p.S60*(1)		NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCTCGCAGCTCATCTGTCTCC	0.463000													3	31					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87564454	87564454	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr7:87564454C>T	ENST00000398204.4	+	2	522	c.199C>T	c.(199-201)Cac>Tac	p.H67Y	ADAM22_ENST00000439864.1_Missense_Mutation_p.H67Y|ADAM22_ENST00000398209.3_Missense_Mutation_p.H67Y|ADAM22_ENST00000398201.4_Missense_Mutation_p.H67Y|ADAM22_ENST00000315984.7_Missense_Mutation_p.H67Y|ADAM22_ENST00000265727.7_Missense_Mutation_p.H67Y	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	67					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CGAAAGTCGGCACGACGCGCT	0.692000													8	45					0	0	1	0	0
PSMD3	5709	broad.mit.edu	37	17	38152557	38152557	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:38152557C>T	ENST00000264639.4	+	10	1616	c.1442C>T	c.(1441-1443)tCc>tTc	p.S481F	PSMD3_ENST00000541736.1_Missense_Mutation_p.S343F	NM_002809.3	NP_002800.2	O43242	PSMD3_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	481					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Colorectal(19;0.000442)					CAGCGCATCTCCTTCTGCCTA	0.562000													32	244					0	0	1	0	0
CDCP2	200008	broad.mit.edu	37	1	54610248	54610248	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:54610248G>A	ENST00000371330.1	-	2	1165	c.318C>T	c.(316-318)tgC>tgT	p.C106C	RP11-446E24.4_ENST00000311841.7_3'UTR|RP11-446E24.4_ENST00000525949.1_5'UTR	NM_201546.2	NP_963840.2	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2	106	CUB 1.					extracellular region				kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|stomach(1)	24						GCACCTTGCCGCAGAACCTCC	0.587000													6	55					0	0	1	0	0
CREB3	10488	broad.mit.edu	37	9	35736273	35736273	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr9:35736273C>T	ENST00000353704.2	+	8	1184	c.746C>T	c.(745-747)tCt>tTt	p.S249F	CREB3_ENST00000486056.1_3'UTR	NM_006368.4	NP_006359.3	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	273					chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|urinary_tract(1)	9	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		ATGTACTCCTCTGACACAAGG	0.547000											OREG0019176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	221					0	0	1	0	0
SNRPA	6626	broad.mit.edu	37	19	41265431	41265431	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:41265431G>C	ENST00000243563.3	+	3	892	c.342G>C	c.(340-342)aaG>aaC	p.K114N	SNRPA_ENST00000599570.1_3'UTR	NM_004596.4	NP_004587.1	P09012	SNRPA_HUMAN	small nuclear ribonucleoprotein polypeptide A	114						nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)	10			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GGAAGCCCAAGAGCCAGGAGA	0.642000													31	72					0	0	1	0	0
ANKRD44	91526	broad.mit.edu	37	2	197990744	197990744	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:197990744C>G	ENST00000328737.2	-	5	280	c.204G>C	c.(202-204)ttG>ttC	p.L68F	ANKRD44_ENST00000539527.1_Missense_Mutation_p.L21F|ANKRD44_ENST00000409919.1_Missense_Mutation_p.L93F|ANKRD44_ENST00000409153.1_Missense_Mutation_p.L93F|ANKRD44_ENST00000450567.1_Missense_Mutation_p.L68F|ANKRD44_ENST00000282272.8_Missense_Mutation_p.L85F|ANKRD44_ENST00000337207.5_Missense_Mutation_p.L68F			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	93							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AGTGCTTAATCAAAACCTGTA	0.463000													22	61					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24124303	24124303	+	Missense_Mutation	SNP	A	A	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr16:24124303A>C	ENST00000303531.7	+	8	983	c.831A>C	c.(829-831)ttA>ttC	p.L277F	PRKCB_ENST00000321728.7_Missense_Mutation_p.L277F	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	277					apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	GGTTTAAGTTACTGAGCCAGG	0.458000													30	79					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113299452	113299452	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr8:113299452C>T	ENST00000297405.5	-	58	9416	c.9172G>A	c.(9172-9174)Gat>Aat	p.D3058N	CSMD3_ENST00000343508.3_Missense_Mutation_p.D3018N|CSMD3_ENST00000455883.2_Missense_Mutation_p.D2889N|CSMD3_ENST00000352409.3_Missense_Mutation_p.D2988N	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3058	Sushi 22.					integral to membrane|plasma membrane		p.D3058N(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTACCTGGATCGCCACATGTC	0.443000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	78					0	0	1	0	0
AFM	173	broad.mit.edu	37	4	74365842	74365842	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:74365842C>T	ENST00000226355.3	+	12	1637	c.1544C>T	c.(1543-1545)gCt>gTt	p.A515V		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	515	Albumin 3.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGTTTGAAAGCTGATAAAACA	0.418000													8	70					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102873781	102873781	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr14:102873781C>G	ENST00000359520.7	+	3	552	c.326C>G	c.(325-327)tCa>tGa	p.S109*	TECPR2_ENST00000561228.1_3'UTR|TECPR2_ENST00000558678.1_Nonsense_Mutation_p.S109*	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	109							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						CTTGTATCTTCATTGCCAGGG	0.438000													11	46					0	0	1	0	0
WDR47	22911	broad.mit.edu	37	1	109554150	109554150	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:109554150G>A	ENST00000357672.3	-	4	809	c.434C>T	c.(433-435)gCa>gTa	p.A145V	WDR47_ENST00000369965.4_Missense_Mutation_p.A173V|WDR47_ENST00000361054.3_Missense_Mutation_p.A145V|WDR47_ENST00000369962.3_Missense_Mutation_p.A173V|WDR47_ENST00000400794.3_Missense_Mutation_p.A180V			O94967	WDR47_HUMAN	WD repeat domain 47	173										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		GATGAATTCTGCAACCATGAC	0.443000													38	226					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59112838	59112838	+	Missense_Mutation	SNP	G	G	T	rs145184753		TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr14:59112838G>T	ENST00000395153.3	+	4	1533	c.1386G>T	c.(1384-1386)gaG>gaT	p.E462D	DACT1_ENST00000556859.1_Missense_Mutation_p.E218D|DACT1_ENST00000541264.2_Missense_Mutation_p.E218D|DACT1_ENST00000335867.4_Missense_Mutation_p.E499D	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	499					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus		p.E499E(1)		endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						CGCCGCAGGAGAACAAAGTTG	0.607000													22	135					7.26314e-15	7.88476e-15	1	1	0
FRMPD4	9758	broad.mit.edu	37	X	12516884	12516884	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chrX:12516884G>A	ENST00000380682.1	+	2	633	c.127G>A	c.(127-129)Gca>Aca	p.A43T		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	43	WW.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						GGAGATGACGGCAAACCGAGA	0.502000													3	32					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42459726	42459726	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr15:42459726G>A	ENST00000318006.5	-	13	1405	c.1243C>T	c.(1243-1245)Caa>Taa	p.Q415*	VPS39_ENST00000348544.4_Nonsense_Mutation_p.Q426*	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	426					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		TTTACCAATTGACTTCGTTTC	0.453000													11	38					0	0	1	0	0
ANKS6	203286	broad.mit.edu	37	9	101540608	101540608	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr9:101540608G>A	ENST00000353234.4	-	7	1514	c.1467C>T	c.(1465-1467)gaC>gaT	p.D489D	ANKS6_ENST00000540940.1_Silent_p.D294D|ANKS6_ENST00000375018.1_Silent_p.D489D|ANKS6_ENST00000375019.2_Silent_p.D188D			Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain containing 6	489										endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	21		Acute lymphoblastic leukemia(62;0.0527)				GCTCAGGCTCGTCAGAGAAAG	0.592000													12	40					0	0	1	0	0
IGLV2-28	28812	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													4	5					0.00909568	0.00917179	1	1	0
ZFYVE9	9372	broad.mit.edu	37	1	52704249	52704249	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:52704249T>G	ENST00000287727.3	+	4	1332	c.1160T>G	c.(1159-1161)cTt>cGt	p.L387R	ZFYVE9_ENST00000371591.1_Missense_Mutation_p.L387R|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.L387R			O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	387					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						ACAGAATTCCTTAATATGACA	0.378000													16	77					0	0	1	0	0
SLX4IP	128710	broad.mit.edu	37	20	10603323	10603323	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr20:10603323A>G	ENST00000334534.5	+	8	703	c.523A>G	c.(523-525)Aca>Gca	p.T175A		NM_001009608.1	NP_001009608.1			SLX4 interacting protein																		AAGAACTGAAACAAAAAGCAG	0.418000													4	60					0	0	1	0	0
UQCC1	55245	broad.mit.edu	37	20	33891852	33891852	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr20:33891852C>A	ENST00000374385.5	-	10	963	c.786G>T	c.(784-786)atG>atT	p.M262I	UQCC1_ENST00000407996.2_Missense_Mutation_p.M125I|UQCC1_ENST00000374380.2_Missense_Mutation_p.M194I|UQCC1_ENST00000397556.3_Missense_Mutation_p.M163I|UQCC1_ENST00000374377.5_Missense_Mutation_p.M150I|UQCC1_ENST00000374384.2_Missense_Mutation_p.M236I|UQCC1_ENST00000540457.1_Missense_Mutation_p.M107I|UQCC1_ENST00000349714.5_Missense_Mutation_p.M235I|UQCC1_ENST00000359226.2_Missense_Mutation_p.M182I	NM_018244.4	NP_060714.3			ubiquinol-cytochrome c reductase complex assembly factor 1	262																	CCTCCCCGTTCATGGAGTCCA	0.597000											OREG0025888	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	118					3.6726e-16	4.00496e-16	1	1	0
PARP10	84875	broad.mit.edu	37	8	145052106	145052106	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr8:145052106G>A	ENST00000313028.7	-	10	2794	c.2700C>T	c.(2698-2700)caC>caT	p.H900H	PARP10_ENST00000525773.1_Silent_p.H912H|PARP10_ENST00000524918.1_Silent_p.H891H	NM_032789.3	NP_116178.2	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	900	Myc binding.|PARP catalytic.					Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(2)	27	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTTGAAGCCGTGGGCGCAGA	0.726000													3	32					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936735	4936735	+	Silent	SNP	G	G	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:4936735G>T	ENST00000322013.3	-	1	187	c.159C>A	c.(157-159)atC>atA	p.I53I	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTTTTAATGATAAAAAGAA	0.507000													29	57					9.39395e-14	1.01522e-13	1	1	0
ENKD1	84080	broad.mit.edu	37	16	67698964	67698964	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr16:67698964G>A	ENST00000243878.4	-	3	709	c.388C>T	c.(388-390)Ctg>Ttg	p.L130L	ENKD1_ENST00000602644.1_Silent_p.L130L|ENKD1_ENST00000602409.1_5'UTR	NM_032140.1	NP_115516.1			enkurin domain containing 1																		AGAGCTTTCAGGGGCCTGGGC	0.597000													35	188					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235904826	235904826	+	Missense_Mutation	SNP	A	A	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:235904826A>C	ENST00000389794.3	-	31	8428	c.8254T>G	c.(8254-8256)Ttg>Gtg	p.L2752V	LYST_ENST00000389793.2_Missense_Mutation_p.L2752V			Q99698	LYST_HUMAN	lysosomal trafficking regulator	2752					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GCTGGCGACAAAATATGCACT	0.443000													21	59					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151261684	151261684	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:151261684C>G	ENST00000368879.2	+	4	2506	c.2408C>G	c.(2407-2409)tCt>tGt	p.S803C		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	803					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCCTTCAAGTCTGGGCCAAGT	0.627000													13	101					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48599354	48599354	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:48599354C>G	ENST00000323776.5	+	10	1460	c.1298C>G	c.(1297-1299)tCt>tGt	p.S433C	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.S396C	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	396					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GCCAGTTCCTCTGATGTCTCC	0.507000													28	67					0	0	1	0	0
WDR19	57728	broad.mit.edu	37	4	39201122	39201122	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:39201122G>A	ENST00000399820.3	+	6	585	c.431G>A	c.(430-432)tGt>tAt	p.C144Y	WDR19_ENST00000288634.7_5'UTR|WDR19_ENST00000506503.1_Missense_Mutation_p.C144Y	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	144					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						AGAATCACTTGTGGATGTTGG	0.338000													7	40					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74385746	74385746	+	Silent	SNP	A	A	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr3:74385746A>C	ENST00000263665.6	-	11	1455	c.1428T>G	c.(1426-1428)acT>acG	p.T476T		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	476	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TGCAGGTGTAAGTTCCAGCAT	0.353000													8	58					0	0	1	0	0
HVCN1	84329	broad.mit.edu	37	12	111099209	111099209	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr12:111099209G>T	ENST00000356742.5	-	3	819	c.66C>A	c.(64-66)agC>agA	p.S22R	HVCN1_ENST00000439744.2_Missense_Mutation_p.S2R|HVCN1_ENST00000548312.1_Missense_Mutation_p.S22R|HVCN1_ENST00000242607.8_Missense_Mutation_p.S22R			Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	22					response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	19						TTAAGAACTTGCTCATCCTCT	0.577000													9	51					0.000442599	0.000457796	1	1	0
PRAMEF22	653606	broad.mit.edu	37	1	13036288	13036288	+	Silent	SNP	A	A	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:13036288A>C	ENST00000376187.1	+	2	360	c.360A>C	c.(358-360)ggA>ggC	p.G120G	PRAMEF6_ENST00000376192.5_Intron	NM_001100631.1	NP_001094101.1	A3QJZ6	PRA22_HUMAN	PRAME family member 22	120										kidney(1)|large_intestine(2)|lung(1)|skin(1)	5						TATGGTCTGGAGCCAGGCCCC	0.522000													22	169					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	28					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40439968	40439968	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:40439968G>A	ENST00000319592.4	-	4	1652	c.943C>T	c.(943-945)Ctg>Ttg	p.L315L	RBM47_ENST00000295971.7_Silent_p.L315L|RBM47_ENST00000514014.1_Silent_p.L277L|RBM47_ENST00000381795.6_Silent_p.L315L|RBM47_ENST00000381793.2_Silent_p.L315L|RBM47_ENST00000515809.1_Intron			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	315	RRM 3.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						GGCTTGGCCAGCGTGACCTCC	0.662000													6	73					0	0	1	0	0
ADAM15	8751	broad.mit.edu	37	1	155025176	155025176	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:155025176G>C	ENST00000356955.2	+	2	210	c.109G>C	c.(109-111)Gag>Cag	p.E37Q	ADAM15_ENST00000447332.3_Missense_Mutation_p.Q46H|ADAM15_ENST00000472434.1_3'UTR|ADAM15_ENST00000368410.2_Missense_Mutation_p.E37Q|ADAM15_ENST00000271836.6_Missense_Mutation_p.E37Q|ADAM15_ENST00000360674.4_Missense_Mutation_p.E37Q|ADAM15_ENST00000359280.4_Missense_Mutation_p.E37Q|ADAM15_ENST00000368413.1_Missense_Mutation_p.E37Q|ADAM15_ENST00000355956.2_Missense_Mutation_p.E37Q|ADAM15_ENST00000449910.2_Missense_Mutation_p.E37Q|ADAM15_ENST00000368412.3_Missense_Mutation_p.E37Q|ADAM15_ENST00000531455.1_Missense_Mutation_p.E47Q	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	37					angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GGCAGAGTCAGAGAAGGCCCC	0.602000											OREG0013847	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	12					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3779158	3779158	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr16:3779158G>A	ENST00000262367.5	-	31	6699	c.5890C>T	c.(5890-5892)Cgt>Tgt	p.R1964C	CREBBP_ENST00000382070.3_Missense_Mutation_p.R1926C	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1964					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGGGCCTCACGCTCGATCTGC	0.711000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						3	5					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14876137	14876137	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:14876137T>C	ENST00000315576.3	-	10	1352	c.901A>G	c.(901-903)Atc>Gtc	p.I301V	EMR2_ENST00000353876.1_Missense_Mutation_p.I208V|EMR2_ENST00000346057.1_Missense_Mutation_p.I252V|EMR2_ENST00000594076.1_Missense_Mutation_p.I208V|EMR2_ENST00000392964.3_Missense_Mutation_p.I40V|EMR2_ENST00000392965.3_Missense_Mutation_p.I301V|EMR2_ENST00000601345.1_Missense_Mutation_p.I301V|EMR2_ENST00000392967.2_Missense_Mutation_p.I301V|EMR2_ENST00000595839.1_Missense_Mutation_p.I159V|EMR2_ENST00000596991.2_Missense_Mutation_p.I301V|EMR2_ENST00000353005.1_Missense_Mutation_p.I159V|EMR2_ENST00000594294.1_Missense_Mutation_p.I252V	NM_013447.3	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	301					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						CTTACCTGGATGGTGTTATTG	0.612000													28	104					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42331514	42331514	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr20:42331514G>C	ENST00000217026.4	+	8	1463	c.1336G>C	c.(1336-1338)Gtt>Ctt	p.V446L	MYBL2_ENST00000396863.4_Missense_Mutation_p.V422L	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	446						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GAGCACACCTGTTAAGACCCT	0.587000													19	73					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20673915	20673915	+	Silent	SNP	C	C	T	rs150429051		TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:20673915C>T	ENST00000525748.1	+	15	2424	c.2151C>T	c.(2149-2151)ctC>ctT	p.L717L	SLC6A5_ENST00000528440.1_3'UTR	NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	717					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	CCATGGTGCTCGGATGGCTAA	0.453000													44	100					0	0	1	0	0
SUPV3L1	6832	broad.mit.edu	37	10	70960244	70960244	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr10:70960244G>A	ENST00000359655.4	+	11	1567	c.1507G>A	c.(1507-1509)Gat>Aat	p.D503N		NM_003171.3	NP_003162.2	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 (S. cerevisiae)	503	Helicase C-terminal.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GAGGCCTGTGGATCCTATAAG	0.433000													10	35					0	0	1	0	0
KRTAP1-1	81851	broad.mit.edu	37	17	39197178	39197178	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:39197178A>G	ENST00000306271.4	-	1	535	c.472T>C	c.(472-474)Tac>Cac	p.Y158H		NM_030967.2	NP_112229.1	Q07627	KRA11_HUMAN	keratin associated protein 1-1	158						extracellular region|keratin filament				NS(2)|endometrium(2)|kidney(5)|lung(4)|prostate(1)	14		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGTCCACAGTAGGATGGGCGG	0.632000													7	50					0	0	1	0	0
ARMC3	219681	broad.mit.edu	37	10	23326372	23326372	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr10:23326372G>C	ENST00000298032.5	+	19	2667	c.2583G>C	c.(2581-2583)ttG>ttC	p.L861F	ARMC3_ENST00000409983.3_Missense_Mutation_p.L854F|ARMC3_ENST00000376528.4_Missense_Mutation_p.L598F	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	861							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TGATGAAGTTGAGAAGTCGAG	0.473000													18	52					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49176018	49176018	+	Silent	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:49176018T>C	ENST00000340334.7	-	17	1973	c.1605A>G	c.(1603-1605)ccA>ccG	p.P535P	FOLH1_ENST00000356696.3_Silent_p.P550P|FOLH1_ENST00000533034.1_Silent_p.P535P|FOLH1_ENST00000256999.2_Silent_p.P550P|FOLH1_ENST00000343844.4_Silent_p.P242P	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	550	NAALADase.|Substrate binding.				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TGTGATACAGTGGATAGCCGC	0.358000													6	33					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32398642	32398642	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chrX:32398642T>G	ENST00000357033.4	-	34	5036	c.4830A>C	c.(4828-4830)gaA>gaC	p.E1610D	DMD_ENST00000378677.2_Missense_Mutation_p.E1606D	NM_000109.3|NM_004006.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1610	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CCCAGGCAACTTCAGAATCCA	0.363000													9	82					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37355564	37355564	+	Splice_Site	SNP	T	T	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr7:37355564T>A	ENST00000310758.4	-	3	726	c.79A>T	c.(79-81)Aaa>Taa	p.K27*	ELMO1_ENST00000442504.1_Splice_Site_p.K27*|ELMO1_ENST00000448602.1_Splice_Site_p.K27*	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	27					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						AGTGGTTTTTTCTGCAAAATA	0.284000													13	142					0	0	1	0	0
PPP1R32	220004	broad.mit.edu	37	11	61249873	61249873	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:61249873T>C	ENST00000338608.2	+	3	325	c.200T>C	c.(199-201)cTg>cCg	p.L67P	PPP1R32_ENST00000432063.2_Missense_Mutation_p.L67P|RP11-286N22.8_ENST00000544880.1_Intron	NM_145017.2	NP_659454.2	Q7Z5V6	CK066_HUMAN	protein phosphatase 1, regulatory subunit 32	67																	CAAGCCAGTCTGGAGGCCTTA	0.612000											OREG0021002	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	66					0	0	1	0	0
SDHAF2	54949	broad.mit.edu	37	11	61213481	61213481	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:61213481A>G	ENST00000301761.2	+	4	513	c.439A>G	c.(439-441)Aaa>Gaa	p.K147E	SDHAF2_ENST00000543265.1_3'UTR|SDHAF2_ENST00000537782.1_3'UTR|RP11-286N22.8_ENST00000543044.1_Missense_Mutation_p.K135E|RP11-286N22.8_ENST00000544880.1_Intron|SDHAF2_ENST00000542074.1_3'UTR	NM_017841.2	NP_060311.1	Q9NX18	SDHF2_HUMAN	succinate dehydrogenase complex assembly factor 2	147					mitochondrial electron transport, succinate to ubiquinone|protein-FAD linkage	mitochondrion	protein binding			large_intestine(3)|lung(4)|ovary(2)	9						TGCTAAAAACAAAAACAAAGA	0.473000											OREG0021000	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	89					0	0	1	0	0
SIN3A	25942	broad.mit.edu	37	15	75722684	75722684	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr15:75722684C>T	ENST00000394947.3	-	2	347	c.33G>A	c.(31-33)ccG>ccA	p.P11P	SIN3A_ENST00000360439.4_Silent_p.P11P|SIN3A_ENST00000394949.4_Silent_p.P11P|SIN3A_ENST00000567289.1_Silent_p.P11P	NM_001145358.1	NP_001138830.1	Q96ST3	SIN3A_HUMAN	SIN3 transcription regulator family member A	11					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	63						CTGCATACACCGGTGACTCCT	0.552000													4	48					0	0	1	0	0
IGLV2-28	28812	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													4	5					0	0	1	0	0
TPBG	7162	broad.mit.edu	37	6	83075791	83075791	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr6:83075791C>T	ENST00000369750.3	+	2	1730	c.1113C>T	c.(1111-1113)ctC>ctT	p.L371L	TPBG_ENST00000543496.1_Silent_p.L371L|TPBG_ENST00000535040.1_Silent_p.L371L			Q13641	TPBG_HUMAN	trophoblast glycoprotein	371					cell adhesion	integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		CTATTTTCCTCCTGGTTTTGT	0.458000													11	66					0	0	1	0	0
KIAA0753	9851	broad.mit.edu	37	17	6502568	6502568	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:6502568G>T	ENST00000361413.3	-	14	2519	c.2161C>A	c.(2161-2163)Cct>Act	p.P721T	KIAA0753_ENST00000589033.1_Missense_Mutation_p.P177T|KIAA0753_ENST00000542606.1_Missense_Mutation_p.P422T|KIAA0753_ENST00000572370.1_Missense_Mutation_p.P422T|KIAA0753_ENST00000575027.1_5'UTR	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	721						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		TCCTGTGCAGGCTGGGCTTTC	0.358000													5	32					0.014758	0.0148195	1	1	0
EHD3	30845	broad.mit.edu	37	2	31489523	31489523	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:31489523C>T	ENST00000322054.5	+	6	1846	c.1561C>T	c.(1561-1563)Ctg>Ttg	p.L521L	EHD3_ENST00000541626.1_3'UTR	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	521	EH.				blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					GCCCAACGAGCTGCCTGCCCA	0.612000													17	140					0	0	1	0	0
CLDN7	1366	broad.mit.edu	37	17	7165263	7165263	+	Missense_Mutation	SNP	A	A	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:7165263A>C	ENST00000538261.3	-	1	1001	c.100T>G	c.(100-102)Tcc>Gcc	p.S34A	CLDN7_ENST00000571881.2_Missense_Mutation_p.S34A|CLDN7_ENST00000360325.7_Missense_Mutation_p.S34A|CLDN7_ENST00000397317.4_Missense_Mutation_p.S34A|RP1-4G17.5_ENST00000577138.1_Missense_Mutation_p.S34A	NM_001185023.1	NP_001171952.1	O95471	CLD7_HUMAN	claudin 7	34					calcium-independent cell-cell adhesion	integral to membrane|lateral plasma membrane|tight junction	identical protein binding|structural molecule activity			kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	6						CCCGCATAGGAGCTCATCTGC	0.612000													4	34					0	0	1	0	0
WDR47	22911	broad.mit.edu	37	1	109566102	109566102	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:109566102C>A	ENST00000357672.3	-	2	408	c.33G>T	c.(31-33)gaG>gaT	p.E11D	WDR47_ENST00000369965.4_Missense_Mutation_p.E11D|WDR47_ENST00000361054.3_Missense_Mutation_p.E11D|WDR47_ENST00000369962.3_Missense_Mutation_p.E11D|WDR47_ENST00000400794.3_Missense_Mutation_p.E11D			O94967	WDR47_HUMAN	WD repeat domain 47	11	LisH.									breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		TGATTTCAACCTCTTTTACAT	0.348000													8	93					5.18039e-06	5.45185e-06	1	1	0
SYCE1	93426	broad.mit.edu	37	10	135371378	135371378	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr10:135371378C>T	ENST00000368517.3	-	6	394	c.256G>A	c.(256-258)Gag>Aag	p.E86K	SYCE1_ENST00000432597.2_Missense_Mutation_p.E86K|SYCE1_ENST00000343131.5_Missense_Mutation_p.E122K|SPRN_ENST00000541506.1_Intron	NM_130784.2	NP_570140.1	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	122					cell division	central element				breast(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|stomach(3)|urinary_tract(1)	19		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CTGTGTGCCTCACTTTCCTTT	0.517000													9	40					0	0	1	0	0
CHSY3	337876	broad.mit.edu	37	5	129241309	129241309	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr5:129241309G>C	ENST00000305031.4	+	1	1145	c.787G>C	c.(787-789)Gat>Cat	p.D263H	CTC-575N7.1_ENST00000515569.1_RNA|CTC-575N7.1_ENST00000503616.1_RNA	NM_175856.4	NP_787052.3	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	263						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		CGCCGACGACGATGTCTACAT	0.572000													17	132					0	0	1	0	0
CHORDC1	26973	broad.mit.edu	37	11	89938633	89938633	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:89938633C>G	ENST00000529726.1	-	1	4013	c.100G>C	c.(100-102)Gat>Cat	p.D34H	CHORDC1_ENST00000320585.6_Missense_Mutation_p.D222H|CHORDC1_ENST00000457199.2_Missense_Mutation_p.D203H|CHORDC1_ENST00000529987.1_Missense_Mutation_p.D34H			Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain (CHORD) containing 1	222	CHORD 1.|Interaction with PPP5C (By similarity).				chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding			endometrium(2)|large_intestine(2)|liver(1)|lung(6)	11		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				CTTACAGCATCTTTTTTAGTC	0.313000													14	28					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52570846	52570846	+	Silent	SNP	A	A	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr10:52570846A>G	ENST00000374001.2	-	10	1553	c.1414T>C	c.(1414-1416)Ttg>Ctg	p.L472L	A1CF_ENST00000282641.2_Silent_p.L480L|ASAH2B_ENST00000483649.1_Intron|A1CF_ENST00000373997.3_Silent_p.L472L|A1CF_ENST00000373993.1_Silent_p.L480L|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000373995.3_Silent_p.L480L|A1CF_ENST00000395489.2_Silent_p.L473L|A1CF_ENST00000395495.1_Silent_p.L425L			Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor						cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding	p.L480M(1)|p.L472M(1)		NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						ATTTTGTACAAGAATAGCTGT	0.393000													6	25					0	0	1	0	0
S100PBP	64766	broad.mit.edu	37	1	33295564	33295564	+	Splice_Site	SNP	G	G	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:33295564G>T	ENST00000373475.5	+	5	1174		c.e5-1		S100PBP_ENST00000373476.1_Splice_Site|S100PBP_ENST00000356689.3_Splice_Site|S100PBP_ENST00000398243.3_Splice_Site	NM_022753.3	NP_073590.2	Q96BU1	S1PBP_HUMAN	S100P binding protein							nucleus	calcium-dependent protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|stomach(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CTTTATTCAAGGACTAATGTT	0.378000													13	55					5.50884e-06	5.7723e-06	1	1	0
STON1	11037	broad.mit.edu	37	2	48807857	48807857	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:48807857C>T	ENST00000309835.3	+	1	95	c.85C>T	c.(85-87)Ctg>Ttg	p.L29L	STON1-GTF2A1L_ENST00000394751.3_Silent_p.L29L|STON1-GTF2A1L_ENST00000405008.1_Silent_p.L29L|STON1_ENST00000406226.1_Silent_p.L29L|STON1_ENST00000404752.1_Silent_p.L29L|STON1-GTF2A1L_ENST00000402114.2_Silent_p.L29L|STON1-GTF2A1L_ENST00000394754.1_Silent_p.L29L|STON1-GTF2A1L_ENST00000309827.2_Silent_p.L29L					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GAATTTTCCTCTGGAGAATCA	0.468000													12	87					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96090504	96090504	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:96090504G>A	ENST00000453304.1	-	16	3025	c.2677C>T	c.(2677-2679)Ctg>Ttg	p.L893L		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	893	Death.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CAAAGATCCAGGATTACGCCA	0.448000													8	82					0	0	1	0	0
MAMDC4	158056	broad.mit.edu	37	9	139753685	139753685	+	Missense_Mutation	SNP	G	G	C	rs145391466	byFrequency	TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr9:139753685G>C	ENST00000445819.1	+	27	3396	c.3346G>C	c.(3346-3348)Ggc>Cgc	p.G1116R	MAMDC4_ENST00000317446.2_Missense_Mutation_p.G1037R|MAMDC4_ENST00000485732.1_3'UTR			Q6UXC1	AEGP_HUMAN	MAM domain containing 4	1116	MAM 6.				protein transport	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	19	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CACTCTGGGCGGCCAGCCAGC	0.657000													10	63					0	0	1	0	0
EVA1B	55194	broad.mit.edu	37	1	36788625	36788625	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:36788625C>T	ENST00000270824.1	-	2	305	c.14G>A	c.(13-15)cGa>cAa	p.R5Q	SH3D21_ENST00000474766.1_Intron|EVA1B_ENST00000490466.1_5'UTR	NM_018166.1	NP_060636.1			eva-1 homolog B (C. elegans)																		CATGTCCCTTCGCGGGGCATC	0.672000													14	66					0	0	1	0	0
PLXNB3	5365	broad.mit.edu	37	X	153033836	153033836	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chrX:153033836G>A	ENST00000538966.1	+	5	1559	c.1288G>A	c.(1288-1290)Ggg>Agg	p.G430R	PLXNB3_ENST00000538543.1_Intron|PLXNB3_ENST00000361971.5_Missense_Mutation_p.G407R|PLXNB3_ENST00000538776.1_Missense_Mutation_p.G60R|PLXNB3_ENST00000538282.1_Missense_Mutation_p.G60R	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	407	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CCAGGCAGATGGGCACATGAT	0.701000													8	34					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50804980	50804980	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:50804980G>A	ENST00000440075.2	+	40	5579	c.5532G>A	c.(5530-5532)ggG>ggA	p.G1844G	MYH14_ENST00000601313.1_Silent_p.G1844G|MYH14_ENST00000596571.1_Silent_p.G1803G|MYH14_ENST00000425460.1_Silent_p.G1811G|MYH14_ENST00000598205.1_Silent_p.G1811G|MYH14_ENST00000376970.2_Silent_p.G1836G|MYH14_ENST00000262269.8_Silent_p.G1844G			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1803					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CAGAGAGCGGGCGGCAGCAGC	0.622000													10	62					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20864424	20864424	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr12:20864424C>T	ENST00000381552.1	+	5	877	c.509C>T	c.(508-510)tCa>tTa	p.S170L	SLCO1C1_ENST00000266509.2_Missense_Mutation_p.S170L|SLCO1C1_ENST00000540354.1_Missense_Mutation_p.S170L|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.S52L|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.S170L			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	170					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					ATGGAAAAATCAAAATCCAAA	0.343000													9	63					0	0	1	0	0
ETNK1	55500	broad.mit.edu	37	12	22814095	22814095	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr12:22814095A>G	ENST00000266517.4	+	4	1012	c.923A>G	c.(922-924)cAt>cGt	p.H308R		NM_018638.4	NP_061108.2	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1	308					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GTGCTTTGCCATAATGACCTA	0.378000													16	70					0	0	1	0	0
NDUFAF7	55471	broad.mit.edu	37	2	37459293	37459293	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:37459293G>C	ENST00000002125.4	+	2	140	c.100G>C	c.(100-102)Gag>Cag	p.E34Q	NDUFAF7_ENST00000336237.6_Missense_Mutation_p.E34Q|NDUFAF7_ENST00000483999.1_Intron	NM_144736.4	NP_653337.1			NADH dehydrogenase (ubiquinone) complex I, assembly factor 7																		CTCCGGGAATGAGCCTGCAGA	0.473000													16	135					0	0	1	0	0
NFXL1	152518	broad.mit.edu	37	4	47857090	47857090	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:47857090T>G	ENST00000507489.1	-	20	2583	c.2407A>C	c.(2407-2409)Aaa>Caa	p.K803Q	NFXL1_ENST00000381538.3_Missense_Mutation_p.K803Q	NM_001278624.1	NP_001265553.1	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like 1	803						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(4)	27						TTTATTCTTTTACAAGGACAT	0.299000													10	82					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196309549	196309549	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:196309549G>A	ENST00000367433.5	-	16	1806	c.1705C>T	c.(1705-1707)Cag>Tag	p.Q569*	KCNT2_ENST00000367431.4_Nonsense_Mutation_p.Q519*|KCNT2_ENST00000451324.2_Nonsense_Mutation_p.Q180*|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000294725.9_Nonsense_Mutation_p.Q569*|KCNT2_ENST00000609185.1_Nonsense_Mutation_p.Q519*	NM_198503.2	NP_940905.2	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	569						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CTTTTTCTCTGCTGGTCTTGG	0.353000													7	72					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80376017	80376017	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr5:80376017T>C	ENST00000265080.4	+	6	1032	c.965T>C	c.(964-966)tTa>tCa	p.L322S	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	322	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		ACTTTAATTTTAGGTAAGTGC	0.318000													11	55					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76781977	76781977	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:76781977C>G	ENST00000286719.7	-	17	2461	c.2105G>C	c.(2104-2106)cGg>cCg	p.R702P		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	702	EF-hand 3.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			ATCAATGCTCCGAGCAAGGTC	0.493000													7	69					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143568	55143568	+	Missense_Mutation	SNP	A	A	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:55143568A>C	ENST00000396331.1	+	6	898	c.541A>C	c.(541-543)Atc>Ctc	p.I181L	LILRB1_ENST00000448689.1_Missense_Mutation_p.I181L|LILRB1_ENST00000396317.1_Missense_Mutation_p.I181L|LILRB1_ENST00000396327.3_Missense_Mutation_p.I181L|LILRB1_ENST00000418536.2_Missense_Mutation_p.I181L|LILRB1_ENST00000396321.2_Missense_Mutation_p.I181L|LILRB1_ENST00000434867.2_Missense_Mutation_p.I181L|LILRB1_ENST00000324602.7_Missense_Mutation_p.I181L|LILRB1_ENST00000396315.1_Missense_Mutation_p.I181L|LILRB1_ENST00000427581.2_Missense_Mutation_p.I217L|LILRB1_ENST00000396332.4_Missense_Mutation_p.I181L	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	181	Ig-like C2-type 2.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GTCCCGCGCCATCTTCTCCGT	0.572000										HNSCC(37;0.09)			31	163					0	0	1	0	0
SLC25A25	114789	broad.mit.edu	37	9	130854274	130854274	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr9:130854274C>T	ENST00000373066.5	+	1	532	c.125C>T	c.(124-126)gCa>gTa	p.A42V	SLC25A25_ENST00000373068.2_Intron|SLC25A25_ENST00000373069.5_Intron|SLC25A25_ENST00000432073.2_Missense_Mutation_p.A42V|RP11-379C10.4_ENST00000453870.1_RNA	NM_001265614.2	NP_001252543.1	Q6KCM7	SCMC2_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	0					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)	10						GACCAGATGGCAAGCTTTTTG	0.577000													54	177					0	0	1	0	0
TNFRSF10B	8795	broad.mit.edu	37	8	22880288	22880288	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr8:22880288C>T	ENST00000276431.4	-	9	1503	c.1219G>A	c.(1219-1221)Gag>Aag	p.E407K	TNFRSF10B_ENST00000542226.1_Missense_Mutation_p.E227K|TNFRSF10B_ENST00000347739.3_Missense_Mutation_p.E378K	NM_003842.4|NM_147187.2	NP_003833.4|NP_671716.2	O14763	TR10B_HUMAN	tumor necrosis factor receptor superfamily, member 10b	407	Death.				activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cell surface receptor linked signaling pathway|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|positive regulation of I-kappaB kinase/NF-kappaB cascade	plasma membrane	caspase activator activity|receptor activity|TRAIL binding			NS(1)|endometrium(2)|large_intestine(7)|liver(1)|lung(3)|skin(1)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0179)|COAD - Colon adenocarcinoma(73;0.0703)		CCCAGCGTCTCCAAGGCATCC	0.532000													10	82					0	0	1	0	0
PGAM2	5224	broad.mit.edu	37	7	44104487	44104487	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr7:44104487C>T	ENST00000297283.3	-	2	596	c.539G>A	c.(538-540)cGa>cAa	p.R180Q		NM_000290.3	NP_000281.2	P15259	PGAM2_HUMAN	phosphoglycerate mutase 2 (muscle)	180					gluconeogenesis|glycolysis|striated muscle contraction	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity			large_intestine(2)|lung(4)|ovary(1)|stomach(1)	8						AATGAGCACTCGCTTGCCGGC	0.652000													9	24					0	0	1	0	0
CPOX	1371	broad.mit.edu	37	3	98304345	98304345	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr3:98304345T>C	ENST00000264193.2	-	5	1330	c.1112A>G	c.(1111-1113)aAg>aGg	p.K371R		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	371						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						ATCACAGTGCTTTTTCACAAG	0.488000													5	336					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197032154	197032154	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:197032154C>A	ENST00000367412.1	-	2	141	c.98G>T	c.(97-99)gGa>gTa	p.G33V		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	33	Sushi 1.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						GGCAATTCTTCCATTTTCCAC	0.318000													43	147					1.62263e-30	1.77751e-30	1	1	0
OR5J2	282775	broad.mit.edu	37	11	55944688	55944688	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:55944688C>T	ENST00000312298.1	+	1	595	c.595C>T	c.(595-597)Ctg>Ttg	p.L199L		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L199M(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					TGAGTTGTTGCTGTTAACCTT	0.453000													284	88					0	0	1	0	0
SCNM1	79005	broad.mit.edu	37	1	151141526	151141526	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:151141526G>A	ENST00000368905.4	+	7	769	c.658G>A	c.(658-660)Gat>Aat	p.D220N		NM_001204856.1|NM_024041.3	NP_001191785.1|NP_076946.1	Q9BWG6	SCNM1_HUMAN	sodium channel modifier 1	220					mRNA processing|RNA splicing	nucleus	metal ion binding|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	17	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTTTGACTCTGATGAGGAGGA	0.423000													11	95					0	0	1	0	0
TMEM67	91147	broad.mit.edu	37	8	94827587	94827587	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr8:94827587T>C	ENST00000453321.3	+	27	2877	c.2819T>C	c.(2818-2820)cTt>cCt	p.L940P	TMEM67_ENST00000409623.3_Missense_Mutation_p.L859P	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67	940					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			GCTACTCTTCTTATTTTTGAT	0.284000													5	23					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58577645	58577645	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr16:58577645C>G	ENST00000317147.5	-	31	4632	c.4300G>C	c.(4300-4302)Gaa>Caa	p.E1434Q	CNOT1_ENST00000441024.2_Missense_Mutation_p.E1434Q|CNOT1_ENST00000569240.1_Missense_Mutation_p.E1429Q|CNOT1_ENST00000245138.4_Missense_Mutation_p.E285Q	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1434					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		ATTCGAGATTCCTCCGAATCC	0.463000													20	45					0	0	1	0	0
LPAR6	10161	broad.mit.edu	37	13	48986488	48986488	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr13:48986488G>A	ENST00000378434.4	-	7	1696	c.72C>T	c.(70-72)ttC>ttT	p.F24F	LPAR6_ENST00000345941.2_Silent_p.F24F|RB1_ENST00000267163.4_Intron	NM_005767.5	NP_005758.2	P43657	LPAR6_HUMAN	lysophosphatidic acid receptor 6	24						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.0?(15)|p.?(4)		NS(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	14						ACACCATGCTGAACATGCACC	0.398000													7	45					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23080278	23080278	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr16:23080278C>T	ENST00000219689.7	-	16	3147	c.3148G>A	c.(3148-3150)Gag>Aag	p.E1050K	USP31_ENST00000567975.1_Missense_Mutation_p.E343K	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	1050	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		AGGGATGACTCCTGGCTTGCC	0.522000													12	99					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151101574	151101574	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr3:151101574G>T	ENST00000474524.1	+	32	4621	c.4583G>T	c.(4582-4584)gGa>gTa	p.G1528V	P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000273432.4_Missense_Mutation_p.G1388V	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1528					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TAGGTAGGAGGAATGTTTGAC	0.403000													4	41					0.00116845	0.0011932	1	1	0
SAP30	8819	broad.mit.edu	37	4	174294599	174294599	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:174294599G>A	ENST00000296504.3	+	2	614	c.374G>A	c.(373-375)aGa>aAa	p.R125K		NM_003864.3	NP_003855.1	O75446	SAP30_HUMAN	Sin3A-associated protein, 30kDa	125	Interaction with NCOR1 (By similarity).				transcription, DNA-dependent	histone deacetylase complex	DNA binding|metal ion binding|protein binding|transcription corepressor activity			large_intestine(1)|lung(2)|ovary(1)	4		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.15e-17)|Epithelial(43;4.33e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.62e-09)|STAD - Stomach adenocarcinoma(60;0.00278)|GBM - Glioblastoma multiforme(59;0.00659)|LUSC - Lung squamous cell carcinoma(193;0.0919)		GTTCGAAACAGAAGAAAGAGA	0.343000													12	103					0	0	1	0	0
SGSM2	9905	broad.mit.edu	37	17	2278935	2278935	+	Silent	SNP	A	A	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:2278935A>T	ENST00000268989.3	+	18	2427	c.2250A>T	c.(2248-2250)tcA>tcT	p.S750S	SGSM2_ENST00000426855.2_Silent_p.S705S|SGSM2_ENST00000574563.1_Silent_p.S705S|RP1-59D14.5_ENST00000574290.1_RNA	NM_014853.2	NP_055668.2	O43147	SGSM2_HUMAN	small G protein signaling modulator 2	705	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		CTCCAGACTCAGGACTGCCCT	0.627000													12	105					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48598774	48598774	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:48598774C>G	ENST00000323776.5	+	9	1421	c.1259C>G	c.(1258-1260)tCt>tGt	p.S420C	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.S383C	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	383					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GGAAGCTCCTCTGAAGACACA	0.537000													3	10					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123196823	123196823	+	Silent	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chrX:123196823C>G	ENST00000371160.1	+	18	2000	c.1710C>G	c.(1708-1710)gcC>gcG	p.A570A	STAG2_ENST00000371157.3_Silent_p.A570A|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000218089.9_Silent_p.A570A|STAG2_ENST00000371144.3_Silent_p.A570A|STAG2_ENST00000371145.3_Silent_p.A570A|STAG2_ENST00000354548.5_Silent_p.A501A	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	570					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						TTGCCGTGGCCCTTCCTCAGT	0.358000													11	28					0	0	1	0	0
GPR64	10149	broad.mit.edu	37	X	19013027	19013027	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chrX:19013027G>C	ENST00000379878.3	-	27	3049	c.2808C>G	c.(2806-2808)caC>caG	p.H936Q	GPR64_ENST00000356606.4_Missense_Mutation_p.H938Q|GPR64_ENST00000340581.3_Missense_Mutation_p.H833Q|GPR64_ENST00000360279.4_Missense_Mutation_p.H930Q|GPR64_ENST00000357991.3_Missense_Mutation_p.H949Q|GPR64_ENST00000379873.2_Intron|GPR64_ENST00000379876.1_Missense_Mutation_p.H928Q|GPR64_ENST00000379869.3_Missense_Mutation_p.H952Q|GPR64_ENST00000354791.3_Missense_Mutation_p.H936Q|GPR64_ENST00000357544.3_Missense_Mutation_p.H922Q	NM_001184833.1	NP_001171762.1	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64	952					neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(18)|stomach(1)|urinary_tract(1)	42	Hepatocellular(33;0.183)					TCCCGCTTGCGTGTACTGAGC	0.373000													20	65					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113761588	113761588	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr3:113761588G>A	ENST00000295878.3	-	4	523	c.377C>T	c.(376-378)cCg>cTg	p.P126L	KIAA1407_ENST00000545063.1_5'UTR	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	126										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						ATTGGCTTCCGGCATAATAGT	0.373000													9	69					0	0	1	0	0
XKR8	55113	broad.mit.edu	37	1	28293439	28293439	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:28293439C>T	ENST00000373884.5	+	3	1524	c.916C>T	c.(916-918)Cat>Tat	p.H306Y		NM_018053.2	NP_060523.2	Q9H6D3	XKR8_HUMAN	XK, Kell blood group complex subunit-related family, member 8	306						integral to membrane				endometrium(1)|large_intestine(2)|lung(1)	4		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;4.72e-24)|Colorectal(126;1.52e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00572)|READ - Rectum adenocarcinoma(331;0.0526)		CTGGGTGACTCATAGCTCCTG	0.632000													6	52					0	0	1	0	0
ZNF517	340385	broad.mit.edu	37	8	146029031	146029031	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr8:146029031G>A	ENST00000359971.3	+	3	146	c.39G>A	c.(37-39)gcG>gcA	p.A13A	ZNF517_ENST00000525105.1_Silent_p.A13A|ZNF517_ENST00000531720.1_Silent_p.A13A|ZNF517_ENST00000526178.1_Intron	NM_213605.2	NP_998770.2	Q6ZMY9	ZN517_HUMAN	zinc finger protein 517	13					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)			TGCAGGAGGCGGTTGTGTTCG	0.552000													13	89					0	0	1	0	0
ZFYVE19	84936	broad.mit.edu	37	15	41102355	41102355	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr15:41102355A>G	ENST00000355341.4	+	5	1159	c.658A>G	c.(658-660)Atg>Gtg	p.M220V	ZFYVE19_ENST00000299173.10_Missense_Mutation_p.M220V|ZFYVE19_ENST00000564258.1_Missense_Mutation_p.M45V|ZFYVE19_ENST00000336455.5_Missense_Mutation_p.M210V|ZFYVE19_ENST00000570108.1_Missense_Mutation_p.M197V	NM_001077268.1	NP_001070736.1	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	220							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CACCCAGGAAATGGAGGCACG	0.577000													10	58					0	0	1	0	0
RSC1A1	6248	broad.mit.edu	37	1	15986433	15986433	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:15986433G>C	ENST00000345034.1	+	1	70	c.70G>C	c.(70-72)Ggt>Cgt	p.G24R	DDI2_ENST00000480945.1_3'UTR	NM_006511.1	NP_006502.1	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1, member 1	24					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)	11		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTGATGTTGGTAATCCTAT	0.468000													26	206					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427759	3427759	+	RNA	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:3427759C>T	ENST00000529482.1	+	0	876																											TGTCTGCACACGTCCTGCAGT	0.612000													4	57					0	0	1	0	0
OGG1	4968	broad.mit.edu	37	3	9807722	9807722	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr3:9807722G>A	ENST00000302036.7	+	7	1521	c.1178G>A	c.(1177-1179)aGa>aAa	p.R393K	OGG1_ENST00000349503.5_Missense_Mutation_p.R326K|OGG1_ENST00000302008.8_3'UTR|CAMK1_ENST00000256460.3_Intron|OGG1_ENST00000449570.2_3'UTR|OGG1_ENST00000383826.5_3'UTR	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	0					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					cctggctccagagatggtcac	0.557000								Base excision repair (BER), DNA glycosylases					5	23					0	0	1	0	0
TBC1D2B	23102	broad.mit.edu	37	15	78305193	78305193	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr15:78305193C>T	ENST00000409931.3	-	9	2313	c.2242G>A	c.(2242-2244)Gat>Aat	p.D748N	TBC1D2B_ENST00000300584.3_Missense_Mutation_p.D748N			Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	748	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						TAGCCGATATCTGGATTCCGC	0.537000													9	31					0	0	1	0	0
LACC1	144811	broad.mit.edu	37	13	44455284	44455284	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr13:44455284G>A	ENST00000441843.1	+	2	648	c.163G>A	c.(163-165)Gat>Aat	p.D55N	LACC1_ENST00000325686.6_Missense_Mutation_p.D55N	NM_001128303.1	NP_001121775.1	Q8IV20	CM031_HUMAN	laccase (multicopper oxidoreductase) domain containing 1	55																	CTATGAAAGGGATGGAGAACA	0.408000													7	55					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65415012	65415012	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chrX:65415012G>A	ENST00000519389.1	+	9	1783	c.1604G>A	c.(1603-1605)aGc>aAc	p.S535N	HEPH_ENST00000336279.5_Missense_Mutation_p.S214N|HEPH_ENST00000374727.3_Missense_Mutation_p.S484N|HEPH_ENST00000419594.1_Missense_Mutation_p.S484N|HEPH_ENST00000343002.2_Missense_Mutation_p.S481N|HEPH_ENST00000441993.2_Missense_Mutation_p.S484N			Q9BQS7	HEPH_HUMAN	hephaestin	481	Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						CAGCCATTCAGCATGCAGCCC	0.522000													6	21					0	0	1	0	0
IKBKB	3551	broad.mit.edu	37	8	42179669	42179669	+	Silent	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr8:42179669C>G	ENST00000520810.1	+	18	2022	c.1836C>G	c.(1834-1836)ctC>ctG	p.L612L	IKBKB_ENST00000522147.1_Intron|IKBKB_ENST00000520835.1_Silent_p.L610L|IKBKB_ENST00000416505.2_Silent_p.L553L|IKBKB_ENST00000379708.3_Silent_p.L389L	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	612					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	ATACGCAGCTCAGGTATGAGC	0.547000													71	44					0	0	1	0	0
SIK1	150094	broad.mit.edu	37	21	44841220	44841220	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr21:44841220G>A	ENST00000270162.6	-	6	659	c.527C>T	c.(526-528)tCa>tTa	p.S176L		NM_173354.3	NP_775490.2	P57059	SIK1_HUMAN	salt-inducible kinase 1	176	Protein kinase.				anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|testis(2)|urinary_tract(1)	21						AGGCTCTCCTGACTTGTAGAA	0.562000													27	135					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13669417	13669417	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr3:13669417C>T	ENST00000404922.3	+	11	2636	c.2517C>T	c.(2515-2517)gcC>gcT	p.A839A	FBLN2_ENST00000492059.1_Silent_p.A839A|FBLN2_ENST00000535798.1_Silent_p.A818A|FBLN2_ENST00000295760.7_Silent_p.A792A	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	838	EGF-like 5; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			ACTGCCAGGCCAGGCAGCGCT	0.637000													15	87					0	0	1	0	0
DPP8	54878	broad.mit.edu	37	15	65808022	65808022	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr15:65808022C>T	ENST00000341861.5	-	1	1589	c.9G>A	c.(7-9)aaG>aaA	p.K3K	DPP8_ENST00000321147.6_Silent_p.K3K|DPP8_ENST00000300141.6_Intron|DPP8_ENST00000559233.1_Silent_p.K3K|DPP8_ENST00000321118.7_Silent_p.K3K|DPP8_ENST00000358939.4_Intron|DPP8_ENST00000339244.5_Silent_p.K3K	NM_197960.2	NP_932064.1	Q6V1X1	DPP8_HUMAN	dipeptidyl-peptidase 8	3					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(11)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GCTCAGATCTCTTCCACATTC	0.443000													7	26					0	0	1	0	0
ZNF791	163049	broad.mit.edu	37	19	12738587	12738587	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:12738587G>C	ENST00000343325.4	+	4	406	c.244G>C	c.(244-246)Gaa>Caa	p.E82Q	ZNF490_ENST00000465656.1_Intron|ZNF791_ENST00000458122.3_Missense_Mutation_p.E50Q|ZNF791_ENST00000446165.1_Missense_Mutation_p.Q61H|ZNF791_ENST00000540038.1_5'UTR	NM_153358.2	NP_699189.2	Q3KP31	ZN791_HUMAN	zinc finger protein 791	82	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)	19						TCAATGTGCAGAAAACTTCAG	0.418000													38	130					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132502854	132502854	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr12:132502854A>G	ENST00000333577.4	+	22	4427	c.4318A>G	c.(4318-4320)Atg>Gtg	p.M1440V	EP400_ENST00000389561.2_Missense_Mutation_p.M1404V|EP400_ENST00000389562.2_Missense_Mutation_p.M1403V|EP400_ENST00000332482.4_Missense_Mutation_p.M1367V|EP400_ENST00000330386.6_Missense_Mutation_p.M1404V			Q96L91	EP400_HUMAN	E1A binding protein p400	1440					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GCGGAAACTCATGGAGGAAAT	0.532000													16	44					0	0	1	0	0
CEP85L	387119	broad.mit.edu	37	6	118790378	118790378	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr6:118790378C>G	ENST00000368491.3	-	12	2732	c.2111G>C	c.(2110-2112)cGg>cCg	p.R704P	CEP85L_ENST00000368488.5_Missense_Mutation_p.R707P	NM_001042475.2	NP_001035940.1	Q5SZL2	CF204_HUMAN	centrosomal protein 85kDa-like	704						centrosome											AAATAGTGGCCGTTTGGAAAG	0.418000													6	97					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50804981	50804981	+	Silent	SNP	C	C	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:50804981C>A	ENST00000440075.2	+	40	5580	c.5533C>A	c.(5533-5535)Cgg>Agg	p.R1845R	MYH14_ENST00000601313.1_Silent_p.R1845R|MYH14_ENST00000596571.1_Silent_p.R1804R|MYH14_ENST00000425460.1_Silent_p.R1812R|MYH14_ENST00000598205.1_Silent_p.R1812R|MYH14_ENST00000376970.2_Silent_p.R1837R|MYH14_ENST00000262269.8_Silent_p.R1845R			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1804					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		AGAGAGCGGGCGGCAGCAGCT	0.622000													10	63					1.08611e-07	1.15309e-07	1	1	0
F11	2160	broad.mit.edu	37	4	187201487	187201487	+	Missense_Mutation	SNP	C	C	T	rs28934608		TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:187201487C>T	ENST00000264692.4	+	9	1153	c.820C>T	c.(820-822)Cgc>Tgc	p.R274C	F11_ENST00000403665.2_Missense_Mutation_p.R326C			P03951	FA11_HUMAN	coagulation factor XI	326	Apple 3.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	CAATGCCGTCCGCTGCCAGTT	0.488000													14	143					0	0	1	0	0
TCF21	6943	broad.mit.edu	37	6	134210675	134210675	+	Missense_Mutation	SNP	G	G	A	rs144842546		TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr6:134210675G>A	ENST00000367882.4	+	1	400	c.140G>A	c.(139-141)gGg>gAg	p.G47E	TCF21_ENST00000237316.3_Missense_Mutation_p.G47E|RP3-323P13.2_ENST00000607573.1_RNA	NM_003206.3	NP_003197.2	O43680	TCF21_HUMAN	transcription factor 21	47					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	13	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		TGCGAGAATGGGTCTCCCCAG	0.602000													4	40					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29788197	29788197	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr18:29788197G>A	ENST00000269202.6	+	9	929	c.882G>A	c.(880-882)ggG>ggA	p.G294G	MEP1B_ENST00000581447.1_Silent_p.G294G	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	294	MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						TTCCCAGGGGGCCAGAGAGTG	0.483000													10	97					0	0	1	0	0
ZNF565	147929	broad.mit.edu	37	19	36673827	36673827	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:36673827G>C	ENST00000355114.5	-	5	1887	c.1161C>G	c.(1159-1161)agC>agG	p.S387R	ZNF565_ENST00000304116.5_Missense_Mutation_p.S347R|ZNF565_ENST00000392173.2_Missense_Mutation_p.S347R			Q8N9K5	ZN565_HUMAN	zinc finger protein 565	347					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(4)|lung(4)|ovary(1)|skin(2)	11	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.206)			TAACTTCTGAGCTGTGAATAA	0.488000													12	72					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117631323	117631323	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr6:117631323C>T	ENST00000368508.3	-	40	6553	c.6355G>A	c.(6355-6357)Ggg>Agg	p.G2119R	ROS1_ENST00000368507.3_Missense_Mutation_p.G2113R	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	2119	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AGGCCTTCCCCTCTCTTTCTA	0.443000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								15	112					0	0	1	0	0
CCDC110	256309	broad.mit.edu	37	4	186380050	186380050	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:186380050T>C	ENST00000307588.3	-	6	1766	c.1691A>G	c.(1690-1692)aAt>aGt	p.N564S	CCDC110_ENST00000510617.1_Missense_Mutation_p.N564S|CCDC110_ENST00000393540.3_Missense_Mutation_p.N527S	NM_152775.3	NP_689988.1	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110	564						nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(9)	30		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		CATTCGATTATTTTCATTATT	0.299000													10	19					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119027295	119027295	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:119027295C>G	ENST00000307417.3	+	8	1196	c.832C>G	c.(832-834)Cag>Gag	p.Q278E	ABCG4_ENST00000449422.2_Missense_Mutation_p.Q278E|ABCG4_ENST00000531739.1_Missense_Mutation_p.Q278E	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	278	ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GAGCCAGGGTCAGTGCATCTT	0.572000													49	122					0	0	1	0	0
NAP1L1	4673	broad.mit.edu	37	12	76461248	76461248	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr12:76461248G>A	ENST00000261182.8	-	4	595	c.109C>T	c.(109-111)Cag>Tag	p.Q37*	NAP1L1_ENST00000393263.3_Nonsense_Mutation_p.Q37*|NAP1L1_ENST00000552342.1_Nonsense_Mutation_p.Q37*|NAP1L1_ENST00000542344.1_5'UTR|NAP1L1_ENST00000548044.1_5'UTR|NAP1L1_ENST00000431879.3_5'UTR|NAP1L1_ENST00000549596.1_Nonsense_Mutation_p.Q37*|NAP1L1_ENST00000535020.2_Nonsense_Mutation_p.Q37*|NAP1L1_ENST00000544816.1_Intron|NAP1L1_ENST00000547773.1_Intron	NM_004537.4|NM_139207.2	NP_004528.1|NP_631946.1	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	37					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	9		Colorectal(145;0.09)				ACAGTTAGCTGACGTGCTTTA	0.358000													10	50					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186544317	186544317	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:186544317G>A	ENST00000431808.1	-	14	2817	c.2254C>T	c.(2254-2256)Ccg>Tcg	p.P752S	SORBS2_ENST00000418609.1_Missense_Mutation_p.P656S|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000355634.5_Missense_Mutation_p.P852S|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000284776.7_Missense_Mutation_p.P752S|SORBS2_ENST00000319471.9_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	752						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding	p.P752S(1)		endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CTGTTGTCCGGCAAGCTCCCC	0.522000													6	288					0	0	1	0	0
SMURF2	64750	broad.mit.edu	37	17	62568017	62568017	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:62568017G>C	ENST00000262435.9	-	10	1102	c.915C>G	c.(913-915)atC>atG	p.I305M	SMURF2_ENST00000578200.1_Intron	NM_022739.3	NP_073576.1	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	305	WW 3.				BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)|skin(4)	22	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			CCGTATTACGGATCTCCCATC	0.398000													4	37					0	0	1	0	0
TMED1	11018	broad.mit.edu	37	19	10945678	10945678	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:10945678C>A	ENST00000214869.2	-	3	495	c.397G>T	c.(397-399)Gag>Tag	p.E133*	TMED1_ENST00000588289.1_5'UTR|TMED1_ENST00000591695.1_Intron	NM_006858.2	NP_006849.1	Q13445	TMED1_HUMAN	transmembrane emp24 protein transport domain containing 1	133					cell-cell signaling|signal transduction|transport	integral to membrane|plasma membrane	receptor binding			breast(1)|central_nervous_system(2)|lung(2)|ovary(3)|prostate(1)|skin(1)	10						CCTTCGACCTCCTCGTCATCC	0.562000													21	160					5.26018e-13	5.65939e-13	1	1	0
MYH3	4621	broad.mit.edu	37	17	10545863	10545863	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:10545863C>T	ENST00000583535.1	-	16	1846	c.1759G>A	c.(1759-1761)Gtg>Atg	p.V587M	MYH3_ENST00000226209.7_Missense_Mutation_p.V587M	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	587	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity	p.V587M(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CTGTAGTCCACGGTGCCCGCA	0.547000													18	144					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58604790	58604790	+	Silent	SNP	A	A	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr14:58604790A>G	ENST00000267485.7	-	2	1481	c.1287T>C	c.(1285-1287)gaT>gaC	p.D429D	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	429						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						AAAACAGGGCATCGTTTTCCT	0.418000													8	55					0	0	1	0	0
ATP5I	521	broad.mit.edu	37	4	667176	667176	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:667176G>A	ENST00000304312.4	-	3	196	c.106C>T	c.(106-108)Cgg>Tgg	p.R36W	ATP5I_ENST00000506525.1_5'UTR	NM_007100.3	NP_009031.1	P56385	ATP5I_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E	36					ATP catabolic process|respiratory electron transport chain		hydrogen ion transmembrane transporter activity			lung(1)|skin(1)	2						TCTTCTGCCCGAGGTTTTAGG	0.468000													22	61					0	0	1	0	0
NSFL1C	55968	broad.mit.edu	37	20	1424401	1424401	+	Nonsense_Mutation	SNP	A	A	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr20:1424401A>C	ENST00000216879.4	-	9	1973	c.1106T>G	c.(1105-1107)tTa>tGa	p.L369*	NSFL1C_ENST00000350991.4_Nonsense_Mutation_p.L371*|NSFL1C_ENST00000381658.4_Nonsense_Mutation_p.L258*|NSFL1C_ENST00000353088.2_Nonsense_Mutation_p.L338*|NSFL1C_ENST00000461211.1_5'UTR|NSFL1C_ENST00000476071.1_Nonsense_Mutation_p.L371*	NM_016143.4	NP_057227.2	Q9UNZ2	NSF1C_HUMAN	NSFL1 (p97) cofactor (p47)	369						chromosome|Golgi stack|nucleus	lipid binding|protein binding			breast(1)|large_intestine(5)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	16						CGGTTATGTTAACCGCTGCAC	0.587000													5	31					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67322218	67322218	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr16:67322218G>A	ENST00000360461.5	+	19	5904	c.3369G>A	c.(3367-3369)ctG>ctA	p.L1123L	PLEKHG4_ENST00000450733.1_Silent_p.L1042L|PLEKHG4_ENST00000379344.3_Silent_p.L1123L|PLEKHG4_ENST00000427155.2_Silent_p.L1123L	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	1123					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		CAGCTCTTCTGGGTCTCCGCT	0.622000													6	111					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179600722	179600722	+	Silent	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:179600722T>C	ENST00000589042.1	-	50	14675	c.14451A>G	c.(14449-14451)acA>acG	p.T4817T	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.T4500T|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Silent_p.T3573T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4500	Ig-like 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCCTGTCACTGTGCAGATGA	0.463000													12	51					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52277750	52277750	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:52277750C>T	ENST00000354831.7	-	17	2088	c.1899G>A	c.(1897-1899)gtG>gtA	p.V633V	NRD1_ENST00000485608.1_5'UTR|NRD1_ENST00000352171.7_Silent_p.V565V|NRD1_ENST00000544028.1_Silent_p.V433V|NRD1_ENST00000539524.1_Silent_p.V501V	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	564					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						ACATGTTTTCCACATACTCAA	0.373000													11	50					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2430643	2430643	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:2430643C>T	ENST00000449969.1	+	19	2635	c.2474C>T	c.(2473-2475)aCg>aTg	p.T825M	PLCH2_ENST00000378488.3_Missense_Mutation_p.T816M|PLCH2_ENST00000378486.3_Missense_Mutation_p.T852M|PLCH2_ENST00000419816.2_Missense_Mutation_p.T852M|PLCH2_ENST00000288766.5_Missense_Mutation_p.T140M			O75038	PLCH2_HUMAN	phospholipase C, eta 2	852	C2.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GGCCAGAGGACGCTGGCCTTC	0.647000													10	33					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23812158	23812158	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr15:23812158G>T	ENST00000314520.3	+	1	1705	c.1229G>T	c.(1228-1230)tGc>tTc	p.C410F	MKRN3_ENST00000564592.1_Intron|MKRN3_ENST00000568252.1_Intron|MKRN3_ENST00000568945.1_Intron	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	410						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		AGGGGTAACTGCCCATTTGGA	0.527000													10	79					7.48243e-07	7.90906e-07	1	1	0
NBPF15	284565	broad.mit.edu	37	1	148594621	148594621	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:148594621G>A	ENST00000442702.2	+	21	3061	c.1994G>A	c.(1993-1995)gGa>gAa	p.G665E	NBPF15_ENST00000369187.3_Missense_Mutation_p.G665E	NM_001170755.1	NP_001164226.1	Q8N660	NBPFF_HUMAN	neuroblastoma breakpoint family, member 15	665	NBPF 6.					cytoplasm		p.G665E(1)		NS(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12	all_hematologic(923;0.032)					TTCCAGATGGGAGTCATATTC	0.443000													66	112					0	0	1	0	0
PSMG2	56984	broad.mit.edu	37	18	12725500	12725500	+	Silent	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr18:12725500T>C	ENST00000317615.6	+	7	1447	c.765T>C	c.(763-765)ttT>ttC	p.F255F	PSMG2_ENST00000585331.2_Silent_p.F224F	NM_020232.4	NP_064617.2	Q969U7	PSMG2_HUMAN	proteasome (prosome, macropain) assembly chaperone 2	255					proteasome assembly	nucleus	protein binding			lung(1)|prostate(2)|skin(1)	4						GATTACTCTTTGGCAGTGGTC	0.368000													19	100					0	0	1	0	0
NEU3	10825	broad.mit.edu	37	11	74716798	74716798	+	Missense_Mutation	SNP	T	T	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:74716798T>A	ENST00000294064.4	+	3	1574	c.647T>A	c.(646-648)aTc>aAc	p.I216N	NEU3_ENST00000545272.1_Missense_Mutation_p.I107N|NEU3_ENST00000531509.1_Missense_Mutation_p.I216N|NEU3_ENST00000532963.1_3'UTR|NEU3_ENST00000544263.1_Missense_Mutation_p.I183N|NEU3_ENST00000529024.1_Intron	NM_006656.5	NP_006647.3	A8K327	A8K327_HUMAN	sialidase 3 (membrane sialidase)	216										kidney(2)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	11						ACCTACTACATCCCTTCCTGG	0.532000													24	114					0	0	1	0	0
EN1	2019	broad.mit.edu	37	2	119604405	119604405	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:119604405C>T	ENST00000295206.6	-	1	849	c.339G>A	c.(337-339)ccG>ccA	p.P113P		NM_001426.3	NP_001417.3	Q05925	HME1_HUMAN	engrailed homeobox 1	113					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	9						AGCCGAAGTCCGGCCTCAGGA	0.687000													19	49					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140281771	140281771	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:140281771G>A	ENST00000296543.5	+	13	1851	c.1528G>A	c.(1528-1530)Gag>Aag	p.E510K	NAA15_ENST00000398947.1_Missense_Mutation_p.E510K	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	510					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						GAAATGTCATGAGATTGAGAG	0.323000													9	57					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176945543	176945543	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:176945543C>T	ENST00000308618.4	-	3	859	c.723G>A	c.(721-723)atG>atA	p.M241I		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	241						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GCTTGTCCTTCATGCGCCGGT	0.692000													8	30					0	0	1	0	0
ITPRIPL1	150771	broad.mit.edu	37	2	96992694	96992694	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:96992694C>T	ENST00000361124.4	+	1	760	c.349C>T	c.(349-351)Ctg>Ttg	p.L117L	ITPRIPL1_ENST00000542887.1_Silent_p.L101L|ITPRIPL1_ENST00000439118.2_Silent_p.L109L|ITPRIPL1_ENST00000536814.1_Silent_p.L101L	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	109						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GGGCTGGATGCTGGGAAACCT	0.562000													15	96					0	0	1	0	0
EIF2B2	8892	broad.mit.edu	37	14	75470322	75470322	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr14:75470322T>G	ENST00000266126.5	+	3	433	c.353T>G	c.(352-354)cTa>cGa	p.L118R		NM_014239.3	NP_055054.1	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	118					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(234;0.00661)		TCCGGAGGCCTAAACGAGGAT	0.522000													5	68					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135621	156135621	+	Missense_Mutation	SNP	C	C	T	rs144347274		TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:156135621C>T	ENST00000329476.3	+	2	1019	c.530C>T	c.(529-531)gCc>gTc	p.A177V	NPY2R_ENST00000506608.1_Missense_Mutation_p.A177V	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	177					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				GGCATCAGTGCCCTGCTGGCA	0.557000													24	40					0	0	1	0	0
KRT26	353288	broad.mit.edu	37	17	38923904	38923904	+	Splice_Site	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:38923904T>C	ENST00000335552.4	-	7	1237	c.1189A>G	c.(1189-1191)Aaa>Gaa	p.K397E		NM_181539.4	NP_853517.2	Q7Z3Y9	K1C26_HUMAN	keratin 26	397	Tail.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(5)	16		Breast(137;0.00526)				GATTTGCTTTTTCTGTGAAGA	0.318000													7	59					0	0	1	0	0
R3HDM2	22864	broad.mit.edu	37	12	57674219	57674219	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr12:57674219C>A	ENST00000402412.1	-	14	1656	c.1266G>T	c.(1264-1266)caG>caT	p.Q422H	R3HDM2_ENST00000441731.2_Missense_Mutation_p.Q69H|R3HDM2_ENST00000403821.2_Missense_Mutation_p.Q408H|R3HDM2_ENST00000358907.2_Missense_Mutation_p.Q408H|R3HDM2_ENST00000347140.3_Missense_Mutation_p.Q408H|R3HDM2_ENST00000413953.2_Missense_Mutation_p.Q135H|RP11-123K3.4_ENST00000548184.1_3'UTR			Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	408	Gln-rich.					nucleus	nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	22						gctgctgctgctgctgttgct	0.572000													9	76					1.12685e-05	1.17056e-05	1	1	0
ADAR	103	broad.mit.edu	37	1	154574770	154574770	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:154574770C>G	ENST00000368474.4	-	2	547	c.348G>C	c.(346-348)agG>agC	p.R116S	ADAR_ENST00000292205.5_Missense_Mutation_p.R159S|ADAR_ENST00000368471.3_5'UTR|ADAR_ENST00000471068.1_5'UTR	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	116					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GTGGCAGACTCCTGCCACGTG	0.542000													10	109					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152283597	152283597	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:152283597T>G	ENST00000368799.1	-	3	3800	c.3765A>C	c.(3763-3765)gaA>gaC	p.E1255D	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1255	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGATGATTGTTCCTGTCCCA	0.567000									Ichthyosis				36	432					0	0	1	0	0
SLC12A6	9990	broad.mit.edu	37	15	34534400	34534400	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr15:34534400T>G	ENST00000354181.3	-	17	2557	c.2065A>C	c.(2065-2067)Agt>Cgt	p.S689R	SLC12A6_ENST00000397702.2_Missense_Mutation_p.S630R|SLC12A6_ENST00000451844.2_Missense_Mutation_p.S501R|SLC12A6_ENST00000290209.5_Missense_Mutation_p.S638R|SLC12A6_ENST00000560611.1_Missense_Mutation_p.S689R|SLC12A6_ENST00000397707.2_Missense_Mutation_p.S674R|SLC12A6_ENST00000558667.1_Missense_Mutation_p.S689R|SLC12A6_ENST00000558589.1_Missense_Mutation_p.S680R|SLC12A6_ENST00000560164.1_Missense_Mutation_p.S501R|SLC12A6_ENST00000458406.2_Missense_Mutation_p.S630R			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	689					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	AGACAGATACTCATTCCCATG	0.363000													19	67					0	0	1	0	0
CUL7	9820	broad.mit.edu	37	6	43012990	43012990	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr6:43012990T>C	ENST00000535468.1	-	15	3351	c.3265A>G	c.(3265-3267)Agg>Ggg	p.R1089G	CUL7_ENST00000265348.3_Missense_Mutation_p.R1005G	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	1005					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			AGGAGGCTCCTGCGGTCCTCT	0.582000													9	59					0	0	1	0	0
POU4F2	5458	broad.mit.edu	37	4	147561864	147561864	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:147561864C>T	ENST00000281321.3	+	2	1382	c.1134C>T	c.(1132-1134)atC>atT	p.I378I		NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	378					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					TCGCCGCCATCGCGGAGAAGC	0.552000													16	109					0	0	1	0	0
UNC45A	55898	broad.mit.edu	37	15	91496417	91496417	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr15:91496417C>T	ENST00000394275.2	+	22	3244	c.2409C>T	c.(2407-2409)gaC>gaT	p.D803D	AC068831.6_ENST00000553321.1_RNA|UNC45A_ENST00000418476.2_Silent_p.D818D	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)	818					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			AGGGCAATGACCGACTGAAGC	0.617000													14	107					0	0	1	0	0
FAM102A	399665	broad.mit.edu	37	9	130710371	130710371	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr9:130710371G>A	ENST00000373095.1	-	6	970	c.595C>T	c.(595-597)Cgg>Tgg	p.R199W	FAM102A_ENST00000373084.4_Missense_Mutation_p.R57W|FAM102A_ENST00000300434.3_Intron	NM_001035254.2	NP_001030331.1	Q5T9C2	F102A_HUMAN	family with sequence similarity 102, member A	199	Ser-rich.									breast(1)|cervix(1)|large_intestine(3)|lung(1)|ovary(4)	10						ATAGTGGGCCGAGCCTTGGGG	0.652000													13	113					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195480082	195480082	+	Silent	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr3:195480082C>G	ENST00000463781.3	-	20	15807	c.15348G>C	c.(15346-15348)ctG>ctC	p.L5116L	MUC4_ENST00000349607.4_Silent_p.L829L|MUC4_ENST00000475231.1_Silent_p.L5064L|MUC4_ENST00000346145.4_Silent_p.L880L	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1873					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGTTCTGACACAGGAAAGAGC	0.627000													17	143					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115531770	115531770	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr10:115531770C>T	ENST00000361048.1	+	8	921	c.594C>T	c.(592-594)caC>caT	p.H198H	PLEKHS1_ENST00000369309.1_Silent_p.H12H|PLEKHS1_ENST00000369312.4_Silent_p.H110H|PLEKHS1_ENST00000369310.3_Silent_p.H192H	NM_024889.4	NP_079165.3			pleckstrin homology domain containing, family S member 1																		GGCAAACTCACCTACAAGATT	0.358000													8	52					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18883572	18883572	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr16:18883572T>C	ENST00000446231.2	-	15	2529	c.2117A>G	c.(2116-2118)cAt>cGt	p.H706R	SMG1_ENST00000389467.3_Missense_Mutation_p.H706R			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	706	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						AATTGAGAAATGTTTCTTTGT	0.343000													4	22					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37198625	37198625	+	Missense_Mutation	SNP	G	G	A	rs147384010	byFrequency	TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr20:37198625G>A	ENST00000262879.6	+	27	4333	c.4049G>A	c.(4048-4050)cGc>cAc	p.R1350H	RALGAPB_ENST00000397040.1_Missense_Mutation_p.R1350H|RALGAPB_ENST00000397038.1_Missense_Mutation_p.R1129H|RALGAPB_ENST00000397042.3_Missense_Mutation_p.R1347H			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	1350	Rap-GAP.				activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TGGGTGGAACGCTATGATGAT	0.468000													11	18					0	0	1	0	0
SHANK3	85358	broad.mit.edu	37	22	51159754	51159754	+	Missense_Mutation	SNP	A	A	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr22:51159754A>T	ENST00000414786.2	+	21	3678	c.3451A>T	c.(3451-3453)Agc>Tgc	p.S1151C	SHANK3_ENST00000262795.3_Missense_Mutation_p.S1181C|SHANK3_ENST00000445220.2_Missense_Mutation_p.S1167C			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1181										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CTCCCCACGGAGCCCAGCCTG	0.672000													5	30					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151424261	151424261	+	Silent	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chrX:151424261G>C	ENST00000370314.4	-	5	778	c.540C>G	c.(538-540)ctC>ctG	p.L180L	GABRA3_ENST00000535043.1_Silent_p.L180L	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	180				L -> P (in Ref. 3; AAH28629).	gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding	p.L180L(1)|p.L70L(1)		breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCATTGTATAGAGGAGGGTTC	0.478000													13	72					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39266581	39266581	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr13:39266581G>A	ENST00000280481.7	+	1	5316	c.5100G>A	c.(5098-5100)gtG>gtA	p.V1700V		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1700					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GATTTATCGTGACAGAGGCCC	0.438000													15	71					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38047451	38047451	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr4:38047451G>A	ENST00000261439.4	+	10	1911	c.1556G>A	c.(1555-1557)aGa>aAa	p.R519K	TBC1D1_ENST00000508802.1_Missense_Mutation_p.R519K	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	519						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						AATAAAGCCAGAGGCCTGCAG	0.433000													7	86					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43783873	43783873	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr15:43783873G>A	ENST00000263801.3	-	4	602	c.350C>T	c.(349-351)aCa>aTa	p.T117I	TP53BP1_ENST00000382044.4_Missense_Mutation_p.T122I|TP53BP1_ENST00000450115.2_Missense_Mutation_p.T122I|TP53BP1_ENST00000382039.3_Missense_Mutation_p.T122I	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	117					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		ATACCTGCTTGTCCTGTTTGG	0.378000								Other conserved DNA damage response genes					16	163					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16328458	16328458	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr6:16328458C>T	ENST00000244769.4	-	8	1020	c.84G>A	c.(82-84)gaG>gaA	p.E28E	ATXN1_ENST00000436367.1_Silent_p.E28E	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	28					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				TAGGGGCCTTCTCCTCGGAGG	0.687000													7	111					0	0	1	0	0
GTF3C2	2976	broad.mit.edu	37	2	27552094	27552094	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:27552094G>A	ENST00000359541.2	-	14	2362	c.1933C>T	c.(1933-1935)Cgt>Tgt	p.R645C	GTF3C2_ENST00000264720.3_Missense_Mutation_p.R645C			Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide 2, beta 110kDa	645						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCGTAAGGACGTCGAAGGTCC	0.488000													113	361					0	0	1	0	0
GSK3B	2932	broad.mit.edu	37	3	119720999	119720999	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr3:119720999G>A	ENST00000264235.8	-	2	1158	c.176C>T	c.(175-177)aCt>aTt	p.T59I	GSK3B_ENST00000316626.5_Missense_Mutation_p.T59I	NM_001146156.1|NM_002093.3	NP_001139628.1|NP_002084.2	P49841	GSK3B_HUMAN	glycogen synthase kinase 3 beta	59	Protein kinase.				axon guidance|epithelial to mesenchymal transition|ER overload response|glycogen metabolic process|hippocampus development|negative regulation of apoptosis|negative regulation of protein binding|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|positive regulation of cell-matrix adhesion|positive regulation of protein complex assembly|positive regulation of protein export from nucleus|positive regulation of Rac GTPase activity|regulation of microtubule-based process|superior temporal gyrus development	Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|nucleus|plasma membrane	ATP binding|beta-catenin binding|NF-kappaB binding|p53 binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|RNA polymerase II transcription factor binding|tau-protein kinase activity|ubiquitin protein ligase binding			endometrium(1)|large_intestine(8)|lung(7)|prostate(2)	18				GBM - Glioblastoma multiforme(114;0.24)	Lithium(DB01356)	AATCACTTTAGTGTCTGTATA	0.468000													36	200					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45872380	45872380	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:45872380G>A	ENST00000391945.4	-	3	208	c.131C>T	c.(130-132)tCa>tTa	p.S44L	ERCC2_ENST00000485403.2_Missense_Mutation_p.S20L|ERCC2_ENST00000221481.6_Missense_Mutation_p.S44L|ERCC2_ENST00000391940.4_Missense_Mutation_p.S20L|ERCC2_ENST00000391944.3_Missense_Mutation_p.S44L	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	44	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCCGGTGCCTGAGGGCATCTC	0.587000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				36	86					0	0	1	0	0
CHPF	79586	broad.mit.edu	37	2	220404516	220404516	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:220404516G>C	ENST00000243776.6	-	4	2165	c.1917C>G	c.(1915-1917)ttC>ttG	p.F639L	CHPF_ENST00000535926.1_Missense_Mutation_p.F477L	NM_024536.5	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	639						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)	21		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GCATGGGAAAGAAGGCCTGCC	0.657000													68	87					0	0	1	0	0
RBM6	10180	broad.mit.edu	37	3	50005469	50005469	+	Missense_Mutation	SNP	A	A	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr3:50005469A>C	ENST00000443081.1	+	3	1134	c.215A>C	c.(214-216)gAt>gCt	p.D72A	RBM6_ENST00000441115.1_Intron|RBM6_ENST00000539992.1_Intron|RBM6_ENST00000266022.4_Missense_Mutation_p.D204A|RBM6_ENST00000422955.1_Intron|RBM6_ENST00000442092.1_Intron			P78332	RBM6_HUMAN	RNA binding motif protein 6	204					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		TCAGATTTGGATTTTAGGGCC	0.448000													13	49					0	0	1	0	0
SLC37A3	84255	broad.mit.edu	37	7	140043314	140043314	+	Silent	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr7:140043314C>G	ENST00000326232.9	-	13	1427	c.1224G>C	c.(1222-1224)gcG>gcC	p.A408A	SLC37A3_ENST00000340308.3_Intron|SLC37A3_ENST00000447932.2_Silent_p.A392A	NM_207113.1	NP_996996.1	Q8NCC5	SPX3_HUMAN	solute carrier family 37, member 3	408					carbohydrate transport|transmembrane transport	integral to membrane				endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|stomach(3)	24	Melanoma(164;0.0142)					GACCCAAGTCCGCAGAAATAG	0.458000													23	57					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166836798	166836798	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr6:166836798C>T	ENST00000510118.1	-	19	2104	c.1764G>A	c.(1762-1764)gcG>gcA	p.A588A	RPS6KA2_ENST00000265678.4_Silent_p.A563A|RPS6KA2_ENST00000481261.2_Silent_p.A474A|RPS6KA2_ENST00000503859.1_Silent_p.A571A|RPS6KA2_ENST00000405189.3_Silent_p.A474A|RPS6KA2_ENST00000509742.1_5'UTR			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	563	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		GCCCGTTCCCCGCGCGCAGCT	0.607000													8	55					0	0	1	0	0
RSBN1L	222194	broad.mit.edu	37	7	77326172	77326172	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr7:77326172T>G	ENST00000334955.8	+	1	413	c.386T>G	c.(385-387)cTg>cGg	p.L129R		NM_198467.2	NP_940869.2	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like							nucleus				central_nervous_system(1)|endometrium(12)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CGCAAACTGCTGGTCCCTCCT	0.667000													11	50					0	0	1	0	0
GNAI3	2773	broad.mit.edu	37	1	110134819	110134819	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr1:110134819C>T	ENST00000369851.4	+	8	1139	c.1029C>T	c.(1027-1029)atC>atT	p.I343I		NM_006496.3	NP_006487.1	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	343					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			NS(1)|endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		CAGATGTCATCATTAAAAACA	0.368000													9	55					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28493883	28493883	+	Splice_Site	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr15:28493883C>G	ENST00000261609.7	-	21	3159		c.e21-1			NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2						DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AGCAATGTTTCTATACAGGAA	0.363000													5	45					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29113437	29113437	+	RNA	SNP	C	C	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr16:29113437C>G	ENST00000564580.1	+	0	1337																											CCTTCTTCCCCTTTGATCCCT	0.493000													13	110					0	0	1	0	0
LEPREL4	10609	broad.mit.edu	37	17	39967426	39967426	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:39967426G>A	ENST00000355468.3	-	3	1039	c.573C>T	c.(571-573)gtC>gtT	p.V191V	LEPREL4_ENST00000393928.1_Silent_p.V191V			Q92791	SC65_HUMAN	leprecan-like 4	191					synaptonemal complex assembly	nucleolus|synaptonemal complex	binding	p.V191V(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	8						ACTCGTCGGCGACGTCCAGCA	0.627000													37	349					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9020798	9020798	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:9020798G>A	ENST00000397910.4	-	20	37507	c.37304C>T	c.(37303-37305)cCt>cTt	p.P12435L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12437	SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGAGTACAGAGGGCCAACACT	0.542000													30	144					0	0	1	0	0
UBA7	7318	broad.mit.edu	37	3	49849972	49849972	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr3:49849972G>A	ENST00000333486.3	-	6	721	c.563C>T	c.(562-564)tCc>tTc	p.S188F	UBA7_ENST00000494212.1_5'UTR	NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	188	2 approximate repeats.				ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AATGCCAGGGGAGCCCTGGGT	0.577000													12	88					0	0	1	0	0
SESN3	143686	broad.mit.edu	37	11	94917602	94917602	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:94917602G>A	ENST00000536441.1	-	6	1255	c.919C>T	c.(919-921)Cat>Tat	p.H307Y	SESN3_ENST00000278499.2_Missense_Mutation_p.H168Y|RP11-712B9.2_ENST00000534864.1_RNA|SESN3_ENST00000393234.1_Missense_Mutation_p.H307Y|SESN3_ENST00000416495.2_Missense_Mutation_p.H307Y|RP11-712B9.2_ENST00000534891.1_RNA	NM_001271594.1|NM_144665.2	NP_001258523.1|NP_653266.2	P58005	SESN3_HUMAN	sestrin 3	307					cell cycle arrest	nucleus				endometrium(5)|large_intestine(6)|lung(3)|skin(1)|stomach(1)	16		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		GGAAATGAATGAAAAGTATCT	0.388000													5	61					0	0	1	0	0
CUL7	9820	broad.mit.edu	37	6	43017748	43017748	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr6:43017748C>A	ENST00000535468.1	-	6	1860	c.1774G>T	c.(1774-1776)Gac>Tac	p.D592Y	CUL7_ENST00000265348.3_Missense_Mutation_p.D508Y	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	508					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TCCTGATGGTCAGGTCCATCC	0.552000													12	147					0.00185496	0.00188627	1	1	0
PCDHB10	56126	broad.mit.edu	37	5	140574147	140574147	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr5:140574147G>A	ENST00000239446.4	+	1	2206	c.2022G>A	c.(2020-2022)ccG>ccA	p.P674P		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		674					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCCTCTCCCGGAGGCGGCCC	0.687000													20	108					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55418487	55418487	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr11:55418487T>G	ENST00000312422.2	+	1	108	c.108T>G	c.(106-108)atT>atG	p.I36M		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				ACATAATCATTCTTCTGGGAA	0.378000													253	626					0	0	1	0	0
KRT40	125115	broad.mit.edu	37	17	39137373	39137373	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:39137373C>T	ENST00000377755.4	-	4	752	c.718G>A	c.(718-720)Gac>Aac	p.D240N	KRT40_ENST00000398486.2_Missense_Mutation_p.D240N			Q6A162	K1C40_HUMAN	keratin 40	240	Linker 12.|Rod.					intermediate filament	structural molecule activity			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9		Breast(137;0.00043)				CTGAGGCGGTCGCCAAGCTGT	0.517000													25	124					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11716615	11716615	+	Silent	SNP	A	A	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr2:11716615A>G	ENST00000381486.2	+	5	891	c.591A>G	c.(589-591)gcA>gcG	p.A197A	GREB1_ENST00000389825.3_Silent_p.A87A|GREB1_ENST00000263834.5_Silent_p.A197A|GREB1_ENST00000381483.2_Silent_p.A197A|GREB1_ENST00000234142.5_Silent_p.A197A	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	197						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TCCGTAATGCACAAGGGACTC	0.488000													25	120					0	0	1	0	0
SNW1	22938	broad.mit.edu	37	14	78205383	78205383	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr14:78205383C>T	ENST00000261531.7	-	4	414	c.352G>A	c.(352-354)Gac>Aac	p.D118N	SLIRP_ENST00000557431.1_Intron|SNW1_ENST00000555761.1_Missense_Mutation_p.D118N|SNW1_ENST00000554775.1_Intron	NM_012245.2	NP_036377.1	Q13573	SNW1_HUMAN	SNW domain containing 1	118					negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		GGAACCAGGTCAGTGTATTTG	0.388000													44	258					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40357464	40357464	+	Silent	SNP	G	G	A			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:40357464G>A	ENST00000221347.6	-	34	15856	c.15849C>T	c.(15847-15849)atC>atT	p.I5283I		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5283	VWFD 13.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGCCATGGCAGATCTGGACTT	0.557000													29	44					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176305281	176305281	+	Silent	SNP	C	C	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr5:176305281C>T	ENST00000329542.4	+	12	2180	c.1906C>T	c.(1906-1908)Ctg>Ttg	p.L636L	UNC5A_ENST00000261961.3_Silent_p.L596L	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	636					apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGGGGACAGCTGATCCAGGA	0.637000													13	42					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81072446	81072446	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr10:81072446delC	ENST00000334512.5	+	25	3716	c.3144delC	c.(3142-3144)gacfs	p.D1048fs	ZMIZ1_ENST00000446377.2_Frame_Shift_Del_p.D114fs	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	1048					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CTTATCTGGACCCCCCCGACC	0.557													7	355	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396278	+	RNA	INS	-	-	T	rs148140777	by1000genomes	TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr10:118396277_118396278insT	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000298771.7_RNA|PNLIPRP2_ENST00000433618.4_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTTT	0.421													4	4	---	---	---	---					
EPS8	2059	broad.mit.edu	37	12	15794728	15794729	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr12:15794728_15794729insT	ENST00000281172.5	-	16	2040_2041	c.1604_1605insA	c.(1603-1605)tatfs	p.Y535fs	EPS8_ENST00000543523.1_Frame_Shift_Ins_p.Y535fs|EPS8_ENST00000543612.1_Frame_Shift_Ins_p.Y535fs|EPS8_ENST00000542903.1_Frame_Shift_Ins_p.Y275fs|EPS8_ENST00000540613.1_Frame_Shift_Ins_p.Y275fs	NM_004447.5	NP_004438.3	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway substrate 8	535	SH3.				cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		TGGATTTGGCATATTTCTTGGG	0.302													17	93	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	76082490	76082491	+	RNA	INS	-	-	T	rs141632958		TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr12:76082490_76082491insT	ENST00000552856.1	-	0	401																											cattctTTTTCTTTTTTTTTTT	0.361													3	2	---	---	---	---					
AC108004.3	0	broad.mit.edu	37	17	260080	260081	+	RNA	INS	-	-	G			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr17:260080_260081insG	ENST00000466740.2	-	0	330																											CCGCGGTCCGTGGGGCACCGGG	0.688													3	6	---	---	---	---					
PTH2	113091	broad.mit.edu	37	19	49926531	49926533	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr19:49926531_49926533delCAG	ENST00000270631.1	-	1	165_167	c.64_66delCTG	c.(64-66)ctgdel	p.L22del		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	22					neuropeptide signaling pathway	extracellular region		p.L22V(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		AGGGCACCACcagcagcagcagc	0.690													7	36	---	---	---	---					
NCOA6	23054	broad.mit.edu	37	20	33334671	33334671	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr20:33334671delG	ENST00000374796.2	-	11	5424	c.2854delC	c.(2854-2856)caafs	p.Q952fs	NCOA6_ENST00000359003.2_Frame_Shift_Del_p.Q952fs			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	952	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						TTAATTCCTTGTTCTCCAGGC	0.398													19	75	---	---	---	---					
NCOA6	23054	broad.mit.edu	37	20	33345607	33345607	+	Frame_Shift_Del	DEL	G	G	-	rs142275375		TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr20:33345607delG	ENST00000374796.2	-	8	3514	c.944delC	c.(943-945)cctfs	p.P316fs	NCOA6_ENST00000359003.2_Frame_Shift_Del_p.P316fs			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	316	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						CCAGCCTGGAGGAACAGGCAC	0.582													24	76	---	---	---	---					
EP300	2033	broad.mit.edu	37	22	41572402	41572403	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FT-A61P-01A-11D-A30E-08	TCGA-FT-A61P-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	017a5892-1703-4938-accc-0ba543b911e4	78743be5-7400-434b-b53b-450432c41ef3	g.chr22:41572402_41572403insC	ENST00000263253.7	+	30	6150_6151	c.4931_4932insC	c.(4930-4935)ctccgafs	p.R1645fs	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1645	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TTCTCTTCACTCCGAAGAGCCC	0.564			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				26	57	---	---	---	---					
