Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM60A	58516	broad.mit.edu	37	12	31446788	31446788	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:31446788C>G	ENST00000337682.4	-	4	674	c.306G>C	c.(304-306)agG>agC	p.R102S	FAM60A_ENST00000395766.1_5'UTR|FAM60A_ENST00000454658.2_Missense_Mutation_p.R102S|FAM60A_ENST00000542983.1_5'UTR|FAM60A_ENST00000539409.1_Intron	NM_001135812.1	NP_001129284.1	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	102										large_intestine(1)|lung(2)	3	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					TGCTTTTTATCCTGTTCCCAG	0.333000													7	35					0	0	1	0	0
CTRB2	440387	broad.mit.edu	37	16	75238077	75238077	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:75238077C>G	ENST00000303037.8	-	7	817	c.774G>C	c.(772-774)aaG>aaC	p.K258N		NM_001025200.3	NP_001020371.3	Q6GPI1	CTRB2_HUMAN	chymotrypsinogen B2	258	Peptidase S1.				digestion|proteolysis	extracellular space	serine-type endopeptidase activity			endometrium(1)|large_intestine(1)|lung(2)	4						CGGCCAGGATCTTCTGCACCC	0.607000													10	141					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130846097	130846097	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:130846097C>T	ENST00000245255.3	+	16	2193	c.1921C>T	c.(1921-1923)Cgg>Tgg	p.R641W		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	641	Piwi.|RNA-binding (By similarity).				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GACAGCTGGGCGGAGGTCAAT	0.478000													17	130					0	0	1	0	0
TAS2R31	259290	broad.mit.edu	37	12	11183288	11183288	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:11183288G>C	ENST00000390675.2	-	1	718	c.647C>G	c.(646-648)tCt>tGt	p.S216C	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176885.2	NP_795366.2	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	216					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|lung(6)	7						GGGATCTTGAGATCCTTTACC	0.408000													21	283					0	0	1	0	0
SHROOM1	134549	broad.mit.edu	37	5	132160002	132160002	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:132160002C>G	ENST00000378679.3	-	7	2155	c.1351G>C	c.(1351-1353)Gat>Cat	p.D451H	SHROOM1_ENST00000378676.1_Missense_Mutation_p.D382H|SHROOM1_ENST00000319854.3_Missense_Mutation_p.D451H	NM_001172700.1	NP_001166171.1	Q2M3G4	SHRM1_HUMAN	shroom family member 1	451					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGCAGTCATCTGCCCCTGCA	0.557000													6	38					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102946423	102946423	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:102946423G>C	ENST00000504592.1	+	13	1724	c.1306G>C	c.(1306-1308)Gag>Cag	p.E436Q	BANK1_ENST00000428908.1_Missense_Mutation_p.E318Q|BANK1_ENST00000444316.2_Missense_Mutation_p.E421Q|BANK1_ENST00000510950.1_3'UTR|BANK1_ENST00000322953.4_Missense_Mutation_p.E451Q|RP11-498M5.2_ENST00000505091.1_RNA|BANK1_ENST00000508653.1_Missense_Mutation_p.E318Q			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	451				H -> R (in Ref. 1; BAB79255).	B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AGATGGAGCTGAGGCAAATGA	0.453000													14	118					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458397	248458397	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:248458397G>T	ENST00000317996.1	-	1	483	c.484C>A	c.(484-486)Ctg>Atg	p.L162M		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GGGAAGCTCAGGGTAGCAACA	0.577000													8	193					0.00307968	0.00312888	1	1	0
SRGAP1	57522	broad.mit.edu	37	12	64485155	64485155	+	Silent	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:64485155C>G	ENST00000355086.3	+	12	2060	c.1536C>G	c.(1534-1536)gtC>gtG	p.V512V	SRGAP1_ENST00000357825.3_Intron|SRGAP1_ENST00000543397.1_Intron|RP11-196H14.2_ENST00000535594.1_RNA	NM_020762.2	NP_065813.1	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	512	Rho-GAP.				axon guidance	cytosol				breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	65			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		AAACATTCGTCAAGGTACTGG	0.483000													6	46					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21920404	21920404	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:21920404A>G	ENST00000328843.6	+	76	12332	c.12301A>G	c.(12301-12303)Aga>Gga	p.R4101G	DNAH11_ENST00000409508.3_Missense_Mutation_p.R4094G			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4101	AAA 6 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGTTGCTGGGAGACTGAGGTT	0.478000									Kartagener syndrome				11	120					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79426591	79426591	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:79426591C>G	ENST00000307745.7	+	27	5866	c.5866C>G	c.(5866-5868)Cag>Gag	p.Q1956E																								CTACTGGAGTCAGAAGTCTCG	0.657000													14	98					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125889616	125889616	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:125889616C>G	ENST00000392693.3	-	4	521	c.394G>C	c.(394-396)Gaa>Caa	p.E132Q	CDON_ENST00000263577.7_Missense_Mutation_p.E132Q	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	132	Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CTTTTTTCTTCTGCTGTAATA	0.393000													25	132					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73167853	73167853	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:73167853T>C	ENST00000377110.3	-	23	3688	c.3445A>G	c.(3445-3447)Atc>Gtc	p.I1149V	TRPM3_ENST00000396280.5_Missense_Mutation_p.I998V|TRPM3_ENST00000423814.3_Missense_Mutation_p.I1176V|TRPM3_ENST00000377111.2_Missense_Mutation_p.I1149V|TRPM3_ENST00000377106.1_Missense_Mutation_p.I1021V|TRPM3_ENST00000357533.2_Missense_Mutation_p.I1153V|TRPM3_ENST00000396292.4_Missense_Mutation_p.I1021V|TRPM3_ENST00000377105.1_Missense_Mutation_p.I1008V|TRPM3_ENST00000396285.1_Missense_Mutation_p.I1008V|TRPM3_ENST00000358082.3_Missense_Mutation_p.I1011V|TRPM3_ENST00000408909.2_Missense_Mutation_p.I1008V|TRPM3_ENST00000360823.2_Missense_Mutation_p.I1011V			Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3							integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						CTGAAGATGATCAGTGGTGGG	0.483000													22	202					0	0	1	0	0
CABP4	57010	broad.mit.edu	37	11	67223087	67223087	+	Missense_Mutation	SNP	G	G	A	rs149056460		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:67223087G>A	ENST00000325656.5	+	1	270	c.193G>A	c.(193-195)Gag>Aag	p.E65K	CABP4_ENST00000438189.2_Intron|CABP4_ENST00000542025.2_3'UTR	NM_145200.3	NP_660201.1	P57796	CABP4_HUMAN	calcium binding protein 4	65					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding			central_nervous_system(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(2)	11			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GACAGGCCCCGAGGCCCCGGG	0.701000													3	24					0	0	1	0	0
SLC22A24	283238	broad.mit.edu	37	11	62910866	62910866	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:62910866G>C	ENST00000417740.1	-	1	827	c.386C>G	c.(385-387)tCc>tGc	p.S129C	SLC22A10_ENST00000525620.1_Intron|SLC22A24_ENST00000326192.5_Missense_Mutation_p.S129C	NM_001136506.2	NP_001129978.2			solute carrier family 22, member 24											kidney(1)|stomach(1)	2						CACGATGGTGGAGAGGAAAGA	0.458000													3	21					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080660	152080660	+	Missense_Mutation	SNP	T	T	G	rs71585886		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152080660T>G	ENST00000368804.1	-	2	5032	c.5033A>C	c.(5032-5034)gAa>gCa	p.E1678A		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1678	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCTCCCCTTCCTGGAGCAG	0.597000													17	170					0	0	1	0	0
C7orf50	84310	broad.mit.edu	37	7	1037363	1037363	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:1037363C>G	ENST00000397098.3	-	5	1409	c.483G>C	c.(481-483)caG>caC	p.Q161H	C7orf50_ENST00000357429.6_Missense_Mutation_p.Q161H|C7orf50_ENST00000488073.1_5'UTR|C7orf50_ENST00000397100.2_Missense_Mutation_p.Q161H			Q9BRJ6	CG050_HUMAN	chromosome 7 open reading frame 50	161							protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		CTTCCGCCTTCTGCACCGTCA	0.672000													12	116					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784366	82784366	+	Missense_Mutation	SNP	A	A	G	rs112239934		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:82784366A>G	ENST00000333891.9	-	2	1928	c.1591T>C	c.(1591-1593)Tct>Cct	p.S531P	PCLO_ENST00000423517.2_Missense_Mutation_p.S531P	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein		Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGCTGTTGAGATGGGGGTTTT	0.557000													8	357					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16359644	16359644	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:16359644C>G	ENST00000354981.2	-	19	3160	c.3003G>C	c.(3001-3003)caG>caC	p.Q1001H	KIF16B_ENST00000378003.2_Missense_Mutation_p.Q227H|KIF16B_ENST00000408042.1_Missense_Mutation_p.Q1001H|KIF16B_ENST00000355755.3_Missense_Mutation_p.Q1001H	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	1001	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						GCGCCTCTCTCTGCTGCTTCT	0.552000													18	164					0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160757993	160757993	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:160757993A>G	ENST00000274547.2	-	9	1191	c.974T>C	c.(973-975)cTa>cCa	p.L325P	GABRB2_ENST00000520240.1_Missense_Mutation_p.L325P|GABRB2_ENST00000517901.1_Missense_Mutation_p.L262P|GABRB2_ENST00000353437.6_Missense_Mutation_p.L325P|GABRB2_ENST00000393959.1_Missense_Mutation_p.L325P|GABRB2_ENST00000517547.1_Missense_Mutation_p.L165P	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	325					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GTAGTTGACTAGGGCATATTC	0.512000													21	93					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242169088	242169088	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:242169088G>A	ENST00000391975.1	-	28	3962	c.3735C>T	c.(3733-3735)agC>agT	p.S1245S	HDLBP_ENST00000391976.2_Silent_p.S1245S|HDLBP_ENST00000310931.4_Silent_p.S1245S|HDLBP_ENST00000427183.2_Silent_p.S1212S	NM_203346.3	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	1245					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CCTCAGAGCTGCTCATGTCAG	0.582000													6	43					0	0	1	0	0
NTN1	9423	broad.mit.edu	37	17	8925911	8925911	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:8925911C>T	ENST00000173229.2	+	2	328	c.221C>T	c.(220-222)cCg>cTg	p.P74L	NTN1_ENST00000546090.1_Missense_Mutation_p.P74L|NTN1_ENST00000538852.1_Missense_Mutation_p.P74L	NM_004822.2	NP_004813.2	O95631	NET1_HUMAN	netrin 1	74	Laminin N-terminal.				apoptosis|axon guidance		protein binding		NTN1/ACLY(2)	central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(5)	13						GGCCGGCCCCCGGCGCGCTAC	0.726000													3	10					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142161801	142161801	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:142161801C>T	ENST00000519811.1	+	7	1009	c.939C>T	c.(937-939)ttC>ttT	p.F313F	DENND3_ENST00000262585.2_Silent_p.F233F|DENND3_ENST00000424248.1_Silent_p.F233F			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	233										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGAGTGCTTCATGGCCTACC	0.602000													36	168					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278974	36278974	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:36278974C>T	ENST00000007510.4	+	21	3651	c.3507C>T	c.(3505-3507)taC>taT	p.Y1169Y	ARHGAP33_ENST00000314737.5_Silent_p.Y1008Y|ARHGAP33_ENST00000378944.5_Silent_p.Y1005Y			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1169					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						AGCCCCTCTACGTCAACCTAG	0.682000													15	80					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12378341	12378341	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:12378341C>T	ENST00000358136.3	+	31	7491	c.7361C>T	c.(7360-7362)tCt>tTt	p.S2454F	VPS13D_ENST00000356315.4_Missense_Mutation_p.S2454F	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2454					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACCAAGCGGTCTTCCCTTCCT	0.443000													11	93					0	0	1	0	0
STMN4	81551	broad.mit.edu	37	8	27099982	27099982	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:27099982G>A	ENST00000350889.4	-	3	154	c.41C>T	c.(40-42)cCg>cTg	p.P14L	STMN4_ENST00000523048.1_Missense_Mutation_p.P14L|STMN4_ENST00000519614.1_Missense_Mutation_p.P14L|STMN4_ENST00000522908.1_Missense_Mutation_p.P14L|STMN4_ENST00000265770.7_Missense_Mutation_p.P14L|STMN4_ENST00000519997.1_Missense_Mutation_p.P5L	NM_030795.2	NP_110422.2	Q9H169	STMN4_HUMAN	stathmin-like 4	14					intracellular signal transduction					endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)	11		Ovarian(32;0.00167)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0214)|Epithelial(17;9.82e-10)|Colorectal(74;0.142)		GGACACCAGCGGGAGCTCCTT	0.567000													9	47					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91691704	91691704	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:91691704G>C	ENST00000359028.2	+	25	6142	c.5917G>C	c.(5917-5919)Gaa>Caa	p.E1973Q	AKAP9_ENST00000356239.3_Missense_Mutation_p.E1961Q|AKAP9_ENST00000491695.1_3'UTR|AKAP9_ENST00000358100.2_Missense_Mutation_p.E1973Q			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1973	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAGGTTGCAAGAATTGGAGGC	0.403000			T	BRAF	papillary thyroid								9	120					0	0	1	0	0
SAP130	79595	broad.mit.edu	37	2	128767935	128767935	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:128767935G>C	ENST00000357702.5	-	7	986	c.855C>G	c.(853-855)atC>atG	p.I285M	SAP130_ENST00000259234.6_Missense_Mutation_p.I259M|SAP130_ENST00000259235.3_Missense_Mutation_p.I285M	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	285					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CAGCAGGAGGGATGGCATTGG	0.448000													4	94					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540297	169540297	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:169540297C>T	ENST00000340806.6	+	1	588	c.588C>T	c.(586-588)gaC>gaT	p.D196D		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	196								p.D196D(1)		breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						TTGACCTGGACGAGAACAAAA	0.517000													12	142					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7768927	7768927	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:7768927G>A	ENST00000358415.4	+	10	1165	c.999G>A	c.(997-999)atG>atA	p.M333I	ITIH2_ENST00000379587.4_Missense_Mutation_p.M322I	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	333	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TGGAAGCAATGAAGACCATAT	0.393000													5	70					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr22:22664186A>G	ENST00000426066.1	+	0	709					NR_027293.1																						CAGATCAAGAAAGCACTCTGA	0.498000													4	105					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119300685	119300685	+	Splice_Site	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:119300685T>C	ENST00000338891.7	-	11	2745		c.e11-2		FAM184A_ENST00000368475.4_Splice_Site|RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000352896.5_Splice_Site|FAM184A_ENST00000521531.1_Splice_Site	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A											breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						TTCAAGAGCCTAGAACAAGAC	0.328000													4	31					0	0	1	0	0
SLC2A3	6515	broad.mit.edu	37	12	8086418	8086418	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:8086418A>T	ENST00000075120.7	-	2	336	c.96T>A	c.(94-96)aaT>aaA	p.N32K		NM_006931.2	NP_008862.1	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 3	32					carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(14)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				Kidney(36;0.0866)		TCTCAGGAGCATTGATGACCC	0.453000											OREG0021656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	73					0	0	1	0	0
KIAA0895L	653319	broad.mit.edu	37	16	67213361	67213361	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:67213361C>G	ENST00000290881.7	-	5	1745	c.819G>C	c.(817-819)tgG>tgC	p.W273C	KIAA0895L_ENST00000561621.1_Missense_Mutation_p.W273C|KIAA0895L_ENST00000563831.2_Intron|KIAA0895L_ENST00000563902.1_Missense_Mutation_p.W273C			Q68EN5	K895L_HUMAN	KIAA0895-like	273										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						TGCCCTCCAACCAGTACTGGC	0.627000													11	105					0	0	1	0	0
TXNIP	10628	broad.mit.edu	37	1	145440476	145440476	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:145440476G>C	ENST00000369317.4	+	5	1116	c.782G>C	c.(781-783)aGg>aCg	p.R261T	TXNIP_ENST00000475171.1_Intron	NM_006472.3	NP_006463.3	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	261					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	21	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CAGAAGATCAGGCCTTCTATC	0.488000													25	186					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230132	140230132	+	Silent	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:140230132G>T	ENST00000378122.3	+	1	2776	c.2052G>T	c.(2050-2052)gtG>gtT	p.V684V	PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Silent_p.V684V|PCDHA8_ENST00000531613.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGTCAGTGGGTGCCACGG	0.652000													26	117					3.28513e-13	3.58993e-13	1	1	0
DNAJC16	23341	broad.mit.edu	37	1	15894468	15894468	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:15894468G>C	ENST00000375847.3	+	15	2309	c.2145G>C	c.(2143-2145)aaG>aaC	p.K715N	DNAJC16_ENST00000483270.1_3'UTR|DNAJC16_ENST00000375849.1_Intron	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	715					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AGCCCCAAAAGACAGTCGAAG	0.488000													12	100					0	0	1	0	0
YWHAZ	7534	broad.mit.edu	37	8	101932934	101932934	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:101932934C>G	ENST00000395957.2	-	7	1066	c.725G>C	c.(724-726)gGa>gCa	p.G242A	YWHAZ_ENST00000395953.2_Missense_Mutation_p.G242A|YWHAZ_ENST00000457309.1_Missense_Mutation_p.G242A|YWHAZ_ENST00000522819.1_Missense_Mutation_p.G122A|YWHAZ_ENST00000353245.3_Missense_Mutation_p.G242A|YWHAZ_ENST00000395956.3_Missense_Mutation_p.G242A|YWHAZ_ENST00000395951.3_Missense_Mutation_p.G242A|YWHAZ_ENST00000395948.2_Missense_Mutation_p.G165A|YWHAZ_ENST00000522542.1_Missense_Mutation_p.G167A|YWHAZ_ENST00000521309.1_Missense_Mutation_p.G122A|YWHAZ_ENST00000395958.2_Missense_Mutation_p.G242A|YWHAZ_ENST00000419477.2_Missense_Mutation_p.G242A			P63104	1433Z_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	242					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding			large_intestine(1)|lung(2)	3	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	ATTTTCCCCTCCTTCTCCTGC	0.453000													6	88					0	0	1	0	0
CHRM4	1132	broad.mit.edu	37	11	46407836	46407836	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:46407836A>G	ENST00000433765.2	-	1	271	c.272T>C	c.(271-273)gTg>gCg	p.V91A		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	91					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	GATGATGTACACGGTGTAGAG	0.577000													10	62					0	0	1	0	0
ENOSF1	55556	broad.mit.edu	37	18	691231	691231	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr18:691231C>T	ENST00000383578.3	-	5	427	c.223G>A	c.(223-225)Gat>Aat	p.D75N	ENOSF1_ENST00000251101.7_Missense_Mutation_p.D157N|ENOSF1_ENST00000340116.7_Missense_Mutation_p.D178N|ENOSF1_ENST00000580982.1_Intron	NM_001126123.3	NP_001119595.1	Q7L5Y1	ENOF1_HUMAN	enolase superfamily member 1	157					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	10						GTCAGGACATCAGTGATGTAC	0.483000													5	83					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56098314	56098314	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:56098314C>T	ENST00000608263.1	-	2	1225	c.564G>A	c.(562-564)aaG>aaA	p.K188K	CTCFL_ENST00000608440.1_Silent_p.K188K|CTCFL_ENST00000429804.3_Silent_p.K188K|CTCFL_ENST00000422869.2_Silent_p.K188K|CTCFL_ENST00000432255.2_Silent_p.K188K|CTCFL_ENST00000243914.3_Silent_p.K188K|CTCFL_ENST00000433949.3_5'UTR|CTCFL_ENST00000423479.3_Silent_p.K188K|CTCFL_ENST00000539382.1_5'UTR|CTCFL_ENST00000608425.1_Silent_p.K188K|CTCFL_ENST00000609232.1_Silent_p.K188K|CTCFL_ENST00000502686.2_Intron|CTCFL_ENST00000608903.1_Intron|CTCFL_ENST00000608158.1_Silent_p.K188K|CTCFL_ENST00000608858.1_Intron|CTCFL_ENST00000481655.2_Silent_p.K188K|CTCFL_ENST00000371196.2_Silent_p.K188K	NM_001269041.1	NP_001255970.1	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like						cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			ATAACTGGTTCTTCTCCTGCT	0.353000													11	74					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125671724	125671724	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:125671724G>C	ENST00000431078.1	+	24	4144	c.3780G>C	c.(3778-3780)cgG>cgC	p.R1260R		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1260					cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCATGACCCGGTTCCTCTACC	0.453000													8	160					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123554332	123554332	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:123554332G>A	ENST00000422452.2	-	25	4874	c.4811C>T	c.(4810-4812)cCg>cTg	p.P1604L	STAG2_ENST00000469481.1_Intron|TENM1_ENST00000371130.3_Missense_Mutation_p.P1597L	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		AAGCCATAGCGGCATTCCGCC	0.493000													3	42					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56745131	56745131	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:56745131C>T	ENST00000314128.4	-	9	909	c.886G>A	c.(886-888)Ggg>Agg	p.G296R	STAT2_ENST00000418572.2_Missense_Mutation_p.G292R|STAT2_ENST00000557235.1_Missense_Mutation_p.G292R			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	296					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						AGGTCCACCCCTTTGGTCAGA	0.572000													27	306					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41684108	41684108	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr21:41684108C>G	ENST00000400454.1	-	9	2439	c.1962G>C	c.(1960-1962)ttG>ttC	p.L654F		NM_001271534.1|NM_001389.3	NP_001258463.1|NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	654	Ig-like C2-type 7.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGAAATCCTCAAGGAGCTCG	0.547000													6	133					0	0	1	0	0
TNFRSF9	3604	broad.mit.edu	37	1	7993281	7993281	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:7993281G>A	ENST00000377507.3	-	7	786	c.620C>T	c.(619-621)aCg>aTg	p.T207M		NM_001561.5	NP_001552.2	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily, member 9	207					induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		GAAACGGAGCGTGAGGAAGAA	0.448000													5	40					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8152753	8152753	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:8152753C>G	ENST00000600128.1	-	53	6989	c.6575G>C	c.(6574-6576)tGt>tCt	p.C2192S	FBN3_ENST00000270509.2_Missense_Mutation_p.C2192S|FBN3_ENST00000601739.1_Missense_Mutation_p.C2192S			Q75N90	FBN3_HUMAN	fibrillin 3	2192	EGF-like 35; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GCCGGCTGGACAGGTGCACAG	0.567000													12	157					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102337572	102337572	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:102337572G>A	ENST00000369138.1	+	11	2072	c.1582G>A	c.(1582-1584)Gac>Aac	p.D528N	GRIK2_ENST00000413795.1_Missense_Mutation_p.D528N|GRIK2_ENST00000421544.1_Missense_Mutation_p.D528N|GRIK2_ENST00000369134.4_Missense_Mutation_p.D479N|GRIK2_ENST00000369137.3_Missense_Mutation_p.D528N|GRIK2_ENST00000318991.6_Missense_Mutation_p.D528N	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	528					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.D528N(2)		NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GAAGGTCATCGACTTTTCCAA	0.423000													14	124					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125850958	125850958	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:125850958G>A	ENST00000392693.3	-	17	3389	c.3262C>T	c.(3262-3264)Cat>Tat	p.H1088Y	CDON_ENST00000531738.1_Missense_Mutation_p.H465Y|CDON_ENST00000263577.7_Missense_Mutation_p.H1088Y	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	1088					cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		ACTAGATGATGAGGATGTTCA	0.463000													33	85					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72172115	72172115	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:72172115C>G	ENST00000356056.5	-	30	6158	c.5686G>C	c.(5686-5688)Gcc>Ccc	p.A1896P	MYO9A_ENST00000444904.1_Missense_Mutation_p.A1877P|MYO9A_ENST00000564571.1_Missense_Mutation_p.A1896P|MYO9A_ENST00000424560.1_Missense_Mutation_p.A1967P	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	1896	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TCCTTCAGGGCTTTTTTAAAT	0.373000													8	58					0	0	1	0	0
LZTS3	9762	broad.mit.edu	37	20	3146671	3146671	+	Silent	SNP	A	A	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:3146671A>C	ENST00000329152.3	-	2	2192	c.795T>G	c.(793-795)ggT>ggG	p.G265G	LZTS3_ENST00000337576.5_Silent_p.G265G|LZTS3_ENST00000360342.3_Silent_p.G265G																							CCGACCCCCCACCGCTGCTGC	0.657000													6	46					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55566659	55566659	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:55566659C>G	ENST00000436346.1	-	13	2300	c.1459G>C	c.(1459-1461)Gaa>Caa	p.E487Q	CCDC88A_ENST00000263630.8_Missense_Mutation_p.E487Q|AC012358.8_ENST00000594078.1_RNA|AC012358.8_ENST00000600219.1_RNA|CCDC88A_ENST00000336838.6_Missense_Mutation_p.E487Q|CCDC88A_ENST00000413716.2_Missense_Mutation_p.E487Q|AC012358.8_ENST00000599352.1_RNA|AC012358.8_ENST00000599475.1_RNA|AC012358.8_ENST00000608103.1_RNA	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	487					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						GCATTGCCTTCTACAGAATCC	0.323000													5	61					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141050834	141050834	+	Nonsense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:141050834G>C	ENST00000239440.4	-	13	2053	c.1988C>G	c.(1987-1989)tCa>tGa	p.S663*	ARAP3_ENST00000508305.1_Intron|ARAP3_ENST00000513878.1_Nonsense_Mutation_p.S325*	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	663					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						GGAATGACCTGAGGGCAAGAG	0.572000													13	71					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116633771	116633771	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:116633771C>A	ENST00000260210.4	-	4	557	c.534G>T	c.(532-534)agG>agT	p.R178S	BUD13_ENST00000375445.3_Missense_Mutation_p.R178S	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	178	Arg-rich.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GACGGATCCTCCTGGGAGGAG	0.582000													33	215					6.04164e-23	6.67098e-23	1	1	0
ATM	472	broad.mit.edu	37	11	108218071	108218071	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:108218071G>C	ENST00000278616.4	+	59	9035	c.8650G>C	c.(8650-8652)Gaa>Caa	p.E2884Q	C11orf65_ENST00000525729.1_Intron|C11orf65_ENST00000526725.1_Intron|ATM_ENST00000452508.2_Missense_Mutation_p.E2884Q|ATM_ENST00000525178.1_3'UTR	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2884	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GCAGTCAGCAGAACTTGTACA	0.313000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			11	26					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42910494	42910494	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:42910494C>T	ENST00000244289.4	-	7	2460	c.2184G>A	c.(2182-2184)ggG>ggA	p.G728G	LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000593491.2_RNA|LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000599276.1_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	728					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				AGCAGAGGTTCCCGCCTGCAC	0.662000													7	42					0	0	1	0	0
DPEP3	64180	broad.mit.edu	37	16	68009821	68009821	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:68009821G>A	ENST00000268793.4	-	10	1762	c.1389C>T	c.(1387-1389)ctC>ctT	p.L463L		NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3	438					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		TCTGAGGCACGAGGTGGGAGT	0.602000													7	55					0	0	1	0	0
USP11	8237	broad.mit.edu	37	X	47092454	47092454	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:47092454C>T	ENST00000377107.2	+	1	366	c.12C>T	c.(10-12)gtC>gtT	p.V4V	USP11_ENST00000218348.3_Silent_p.V47V			P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	47					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|ovary(3)|pancreas(1)|stomach(1)	40						tggcgacggtcgcagcaaatc	0.647000													7	16					0	0	1	0	0
MBNL2	10150	broad.mit.edu	37	13	97986694	97986694	+	Splice_Site	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr13:97986694G>T	ENST00000345429.6	+	3	1120	c.339G>T	c.(337-339)gtG>gtT	p.V113V	MBNL2_ENST00000343600.4_Splice_Site_p.V113V|MBNL2_ENST00000376673.3_Splice_Site_p.V113V|MBNL2_ENST00000397601.1_Splice_Site_p.V113V|MBNL2_ENST00000445661.2_Splice_Site_p.V113V	NM_144778.3	NP_659002.1	Q5VZF2	MBNL2_HUMAN	muscleblind-like splicing regulator 2	113					mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(7)|prostate(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			TTCATCCAGTGGTGAGTACAT	0.433000													3	56					0.004672	0.00473152	1	1	0
FBXW7	55294	broad.mit.edu	37	4	153247165	153247165	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:153247165G>A	ENST00000281708.4	-	10	2866	c.1637C>T	c.(1636-1638)tCa>tTa	p.S546L	FBXW7_ENST00000603548.1_Missense_Mutation_p.S546L|FBXW7_ENST00000603841.1_Missense_Mutation_p.S546L|FBXW7_ENST00000393956.3_Missense_Mutation_p.S370L|FBXW7_ENST00000296555.5_Missense_Mutation_p.S428L|FBXW7_ENST00000263981.5_Missense_Mutation_p.S466L	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	546					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TACCTGTAATGAATAGACTCT	0.398000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								13	86					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113299395	113299395	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:113299395T>A	ENST00000297405.5	-	58	9473	c.9229A>T	c.(9229-9231)Act>Tct	p.T3077S	CSMD3_ENST00000455883.2_Missense_Mutation_p.T2908S|CSMD3_ENST00000343508.3_Missense_Mutation_p.T3037S|CSMD3_ENST00000352409.3_Missense_Mutation_p.T3007S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3077	Sushi 22.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TAACGTACAGTACTTTTAGTT	0.473000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	130					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167320	140167320	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:140167320C>T	ENST00000504120.2	+	1	1445	c.1445C>T	c.(1444-1446)gCg>gTg	p.A482V	PCDHA1_ENST00000394633.3_Missense_Mutation_p.A482V|PCDHA1_ENST00000378133.3_Missense_Mutation_p.A482V	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGGACGCGGACGCGCAG	0.657000													9	173					0	0	1	0	0
TRIB2	28951	broad.mit.edu	37	2	12863643	12863643	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:12863643C>T	ENST00000155926.4	+	2	1947	c.528C>T	c.(526-528)ctC>ctT	p.L176L	TRIB2_ENST00000405331.3_Silent_p.L176L|TRIB2_ENST00000381465.2_Silent_p.L40L	NM_021643.3	NP_067675.1	Q92519	TRIB2_HUMAN	tribbles pseudokinase 2	176	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(5)|prostate(1)|skin(1)|stomach(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TGCGGGACCTCAAGCTGCGGA	0.562000													12	89					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55259449	55259449	+	Missense_Mutation	SNP	G	G	A	rs146121458		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:55259449G>A	ENST00000275493.2	+	21	2684	c.2507G>A	c.(2506-2508)cGc>cAc	p.R836H	EGFR_ENST00000454757.2_Missense_Mutation_p.R783H|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000455089.1_Missense_Mutation_p.R791H	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	836	Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.R836H(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TTGGTGCACCGCGACCTGGCA	0.537000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			10	117					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111408294	111408294	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:111408294G>C	ENST00000535254.1	-	17	2039	c.1972C>G	c.(1972-1974)Ctg>Gtg	p.L658V	BUB1_ENST00000409311.1_Missense_Mutation_p.L678V|BUB1_ENST00000302759.6_Missense_Mutation_p.L678V	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	678					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		GGCTGGCTCAGACGAAGTAAG	0.502000													3	48					0	0	1	0	0
SMAD7	4092	broad.mit.edu	37	18	46476250	46476250	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr18:46476250G>C	ENST00000262158.2	-	1	831	c.545C>G	c.(544-546)tCt>tGt	p.S182C	SMAD7_ENST00000589634.1_Missense_Mutation_p.S182C	NM_001190821.1|NM_005904.3	NP_001177750.1|NP_005895.1	O15105	SMAD7_HUMAN	SMAD family member 7	182	MH1.				adherens junction assembly|artery morphogenesis|BMP signaling pathway|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	activin binding|beta-catenin binding|I-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	10	Colorectal(1;0.0518)					CTTCCCGTAAGATTCACAGCA	0.572000											OREG0024975	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	53					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125798151	125798151	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:125798151G>T	ENST00000346248.5	-	5	1712	c.1070C>A	c.(1069-1071)gCc>gAc	p.A357D	CHST15_ENST00000435907.1_Missense_Mutation_p.A357D|CHST15_ENST00000421115.1_Missense_Mutation_p.A357D	NM_015892.4	NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	357					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						GAACGTCCAGGCATTATTATC	0.547000													10	52					3.86212e-05	4.0005e-05	1	1	0
XIRP1	165904	broad.mit.edu	37	3	39230134	39230134	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:39230134G>T	ENST00000340369.3	-	2	1031	c.803C>A	c.(802-804)tCt>tAt	p.S268Y	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.S268Y	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	268							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCAGCGGGCAGACCTCACCGC	0.662000													23	91					1.22574e-08	1.31684e-08	1	1	0
FTSJ2	29960	broad.mit.edu	37	7	2274900	2274900	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:2274900G>C	ENST00000242257.8	-	3	626	c.598C>G	c.(598-600)Caa>Gaa	p.Q200E	FTSJ2_ENST00000407040.1_Missense_Mutation_p.Q106E|FTSJ2_ENST00000440306.2_3'UTR|FTSJ2_ENST00000486040.1_5'UTR	NM_013393.1	NP_037525.1	Q9UI43	RRMJ2_HUMAN	FtsJ RNA methyltransferase homolog 2 (E. coli)	200					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		CGACGGCTTTGACTTCCAGCC	0.507000													15	105					0	0	1	0	0
TMEM106C	79022	broad.mit.edu	37	12	48360997	48360997	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:48360997C>T	ENST00000429772.2	+	7	722	c.609C>T	c.(607-609)ttC>ttT	p.F203F	TMEM106C_ENST00000449758.2_Silent_p.F184F|TMEM106C_ENST00000552546.1_Silent_p.F132F|TMEM106C_ENST00000552561.1_Silent_p.F203F|TMEM106C_ENST00000256686.6_Silent_p.F184F|TMEM106C_ENST00000550552.1_Silent_p.F184F|TMEM106C_ENST00000549288.1_Intron	NM_001143842.1	NP_001137314.1	Q9BVX2	T106C_HUMAN	transmembrane protein 106C	203						endoplasmic reticulum membrane|integral to membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(3)|upper_aerodigestive_tract(1)	14		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		GTAGCTTCTTCTGCACGGTAC	0.488000													45	215					0	0	1	0	0
NACA2	342538	broad.mit.edu	37	17	59668370	59668370	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:59668370C>T	ENST00000521764.1	-	1	193	c.172G>A	c.(172-174)Gaa>Aaa	p.E58K		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	58					protein transport	cytoplasm|nucleus				large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					TCATCAATTTCAGCTGCTGCC	0.493000													37	165					0	0	1	0	0
HDAC5	10014	broad.mit.edu	37	17	42171034	42171034	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:42171034T>A	ENST00000225983.6	-	4	589	c.266A>T	c.(265-267)cAg>cTg	p.Q89L	HDAC5_ENST00000336057.5_Missense_Mutation_p.Q88L|HDAC5_ENST00000586802.1_Missense_Mutation_p.Q88L|HDAC5_ENST00000393622.2_Missense_Mutation_p.Q88L			Q9UQL6	HDAC5_HUMAN	histone deacetylase 5	88	Poly-Gln.				B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		cttctgcagctgctgctgctg	0.622000													3	32					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111408235	111408235	+	Silent	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:111408235A>G	ENST00000535254.1	-	17	2098	c.2031T>C	c.(2029-2031)gcT>gcC	p.A677A	BUB1_ENST00000409311.1_Silent_p.A697A|BUB1_ENST00000302759.6_Silent_p.A697A	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	697					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TGAGTCTGCAAGCCTCAACGC	0.537000													4	39					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35387983	35387983	+	Silent	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:35387983C>G	ENST00000311565.4	+	5	559	c.210C>G	c.(208-210)ctC>ctG	p.L70L	PPARD_ENST00000540939.1_Intron|PPARD_ENST00000418635.2_Intron|PPARD_ENST00000444397.1_Silent_p.L70L|PPARD_ENST00000448077.2_Silent_p.L31L|PPARD_ENST00000337400.2_Silent_p.L70L|PPARD_ENST00000360694.3_Silent_p.L70L	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	70					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	GCGGCAGCCTCAACATGGAGT	0.652000													12	71					0	0	1	0	0
WFDC3	140686	broad.mit.edu	37	20	44416554	44416554	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:44416554C>G	ENST00000243938.4	-	4	362	c.279G>C	c.(277-279)gaG>gaC	p.E93D	WFDC3_ENST00000372632.2_Intron|WFDC3_ENST00000481847.1_5'UTR|WFDC3_ENST00000372630.2_Intron	NM_080614.1	NP_542181.1	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3	93	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			endometrium(1)|large_intestine(3)|prostate(1)	5		Myeloproliferative disorder(115;0.0122)				CTGGACATGTCTCATCAGTGA	0.463000													6	73					0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32476278	32476278	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:32476278G>C	ENST00000404025.2	-	5	1143	c.655C>G	c.(655-657)Caa>Gaa	p.Q219E	NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000360906.5_Missense_Mutation_p.Q219E|NLRC4_ENST00000402280.1_Missense_Mutation_p.Q219E			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	219	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TCCAGGAGTTGATCACAGAGG	0.517000													15	71					0	0	1	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136324257	136324257	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:136324257G>A	ENST00000371929.3	+	29	4683	c.4239G>A	c.(4237-4239)ccG>ccA	p.P1413P	ADAMTS13_ENST00000355699.2_Silent_p.P1357P|ADAMTS13_ENST00000371910.1_Silent_p.P209P|ADAMTS13_ENST00000485925.1_3'UTR|ADAMTS13_ENST00000371916.1_3'UTR|ADAMTS13_ENST00000356589.2_Silent_p.P1326P	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	1413	CUB 2.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CATGGGTACCGGAGATGCAGG	0.597000													3	27					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31439030	31439030	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:31439030G>A	ENST00000373747.3	-	13	1987	c.1888C>T	c.(1888-1890)Cag>Tag	p.Q630*	PUM1_ENST00000490546.1_5'UTR|PUM1_ENST00000423018.2_Nonsense_Mutation_p.Q485*|PUM1_ENST00000424085.2_Nonsense_Mutation_p.Q387*|PUM1_ENST00000373742.2_Nonsense_Mutation_p.Q570*|PUM1_ENST00000426105.2_Nonsense_Mutation_p.Q629*|PUM1_ENST00000373741.4_Nonsense_Mutation_p.Q665*|PUM1_ENST00000257075.5_Nonsense_Mutation_p.Q629*|PUM1_ENST00000440538.2_Nonsense_Mutation_p.Q603*	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	629					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		ggctggggctgaggctgCTGT	0.537000													29	98					0	0	1	0	0
NKPD1	284353	broad.mit.edu	37	19	45656023	45656023	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:45656023G>A	ENST00000317951.4	-	4	1671	c.1672C>T	c.(1672-1674)Cgc>Tgc	p.R558C	NKPD1_ENST00000429338.1_Missense_Mutation_p.R336C|NKPD1_ENST00000589776.1_Missense_Mutation_p.R336C|NKPD1_ENST00000438936.2_Missense_Mutation_p.R336C	NM_198478.3	NP_940880.3			NTPase, KAP family P-loop domain containing 1											endometrium(1)|lung(4)|prostate(2)|urinary_tract(1)	8		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		CACGGCTTGCGCGTCATCTCG	0.721000													5	16					0	0	1	0	0
AMIGO3	386724	broad.mit.edu	37	3	49756220	49756220	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:49756220G>A	ENST00000535833.1	-	10	4129	c.679C>T	c.(679-681)Ctc>Ttc	p.L227F	GMPPB_ENST00000480687.1_3'UTR|RNF123_ENST00000433785.1_Intron|RNF123_ENST00000327697.6_Intron|RNF123_ENST00000497099.1_Intron|AMIGO3_ENST00000320431.7_Missense_Mutation_p.L227F			Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	227	LRRCT.				heterophilic cell-cell adhesion	integral to membrane				endometrium(1)|pancreas(1)|prostate(2)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGGTGGTAGAGGCGGCAGTCG	0.657000													8	86					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47395912	47395912	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:47395912C>G	ENST00000310638.4	-	12	1466	c.1435G>C	c.(1435-1437)Gag>Cag	p.E479Q	CYP4A11_ENST00000462347.1_Missense_Mutation_p.E381Q|CYP4A11_ENST00000371904.4_Missense_Mutation_p.E480Q	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	479					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	GGCAGCAGCTCAAAGCGGAGC	0.547000													11	151					0	0	1	0	0
MTHFSD	64779	broad.mit.edu	37	16	86565621	86565621	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:86565621T>C	ENST00000322911.6	-	8	1195	c.1145A>G	c.(1144-1146)aAg>aGg	p.K382R	MTHFSD_ENST00000546093.1_Missense_Mutation_p.K220R|MTHFSD_ENST00000381214.5_Missense_Mutation_p.K383R|MTHFSD_ENST00000360900.6_Missense_Mutation_p.K383R|MTHFSD_ENST00000543303.2_Missense_Mutation_p.K382R	NM_001159377.1|NM_022764.2	NP_001152849.1|NP_073601.2	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain containing	383					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding			endometrium(1)|large_intestine(3)|lung(6)|skin(1)	11						ACGAGGTCACTTGTCCCTCTG	0.701000													3	18					0	0	1	0	0
MIR520H	574493	broad.mit.edu	37	19	54245814	54245814	+	RNA	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:54245814G>A	ENST00000385126.1	+	0	49					NR_030215.1																						TGTTGTCTGAGAAAAAACAAA	0.413000													15	83					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92703069	92703069	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:92703069C>T	ENST00000257068.2	+	1	184	c.178C>T	c.(178-180)Ctg>Ttg	p.L60L		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	60					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GGGCAACCTCCTGGTGATCCT	0.667000													5	13					0	0	1	0	0
GOLPH3	64083	broad.mit.edu	37	5	32143969	32143969	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:32143969C>A	ENST00000265070.6	-	2	558	c.243G>T	c.(241-243)tgG>tgT	p.W81C	GOLPH3_ENST00000512668.1_Intron	NM_022130.3	NP_071413.1	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3 (coat-protein)	81					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11						TACAGTCATTCCAAAATGATG	0.318000													8	68					1.06961e-07	1.13758e-07	1	1	0
APOB	338	broad.mit.edu	37	2	21229266	21229266	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:21229266T>A	ENST00000233242.1	-	26	10601	c.10474A>T	c.(10474-10476)Att>Ttt	p.I3492F		NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	3492	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATGACTCAATGGAAAAGTAA	0.418000													19	83					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168101899	168101899	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:168101899G>C	ENST00000409195.1	+	9	4086	c.3997G>C	c.(3997-3999)Gaa>Caa	p.E1333Q	XIRP2_ENST00000295237.9_Missense_Mutation_p.E1333Q|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.E1111Q	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1158					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GTCCTATCATGAAGTGACCAC	0.383000													10	60					0	0	1	0	0
HMGA2	8091	broad.mit.edu	37	12	66308892	66308892	+	Silent	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:66308892T>C	ENST00000354636.3	+	4	1114	c.303T>C	c.(301-303)agT>agC	p.S101S	AC090673.2_ENST00000601398.1_Intron|HMGA2_ENST00000536545.1_3'UTR|HMGA2_ENST00000403681.2_Intron|HMGA2_ENST00000393577.3_Intron|HMGA2_ENST00000541363.1_Intron	NM_003484.1	NP_003475.1	P52926	HMGA2_HUMAN	high mobility group AT-hook 2	101					cell division|chromatin organization|mitosis|multicellular organismal development|regulation of growth|transcription, DNA-dependent	chromatin	AT DNA binding		HMGA2/RAD51B(11)|HMGA2/CCNB1IP1(2)|HMGA2/WIF1_ENST00000286574(14)|HMGA2/ALDH2_ENST00000261733(2)|HMGA2/EBF1(2)|HMGA2/LHFP(2)|HMGA2/NFIB_ENST00000397581(8)|HMGA2/LPP(161)|HMGA2/FHIT_ENST00000476844(4)|HMGA2/COX6C(2)	lung(2)	2	all_cancers(1;5.78e-46)		GBM - Glioblastoma multiforme(1;0.00179)|LUSC - Lung squamous cell carcinoma(43;0.156)	GBM - Glioblastoma multiforme(28;0.0386)		TGGGAAACAGTACCAAAAGGA	0.423000			T	""" LHFP, RAD51L1, LPP, COX6C, CMKOR1, NFIB, ALDH2, CCNB1IP1, EBF1, WIF1, FHIT"""	"""lipoma, leiomyoma, pleiomorphic salivary gland adenoma"""								12	257					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151771906	151771906	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:151771906G>A	ENST00000535741.1	-	24	4447	c.3974C>T	c.(3973-3975)tCa>tTa	p.S1325L	LRBA_ENST00000357115.3_Missense_Mutation_p.S1325L|LRBA_ENST00000510413.1_Missense_Mutation_p.S1325L|LRBA_ENST00000507224.1_Missense_Mutation_p.S1325L			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1325						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					TGTTTCTATTGAAAATAATAG	0.343000													5	23					0	0	1	0	0
PHYHD1	254295	broad.mit.edu	37	9	131704017	131704017	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:131704017C>T	ENST00000308941.5	+	12	1299	c.879C>T	c.(877-879)ctC>ctT	p.L293L	RP11-101E3.5_ENST00000482796.1_Intron|PHYHD1_ENST00000353176.5_3'UTR|PHYHD1_ENST00000372592.3_3'UTR|PHYHD1_ENST00000421063.2_3'UTR	NM_174933.3	NP_777593.2			phytanoyl-CoA dioxygenase domain containing 1											central_nervous_system(1)|endometrium(2)|large_intestine(3)|skin(1)|stomach(3)	10						CAGGAGCCCTCGCCCCTCCCG	0.592000													11	47					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50339459	50339459	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:50339459C>T	ENST00000394697.2	+	13	1981	c.1641C>T	c.(1639-1641)gaC>gaT	p.D547D	ADCY7_ENST00000538642.1_Silent_p.D547D|ADCY7_ENST00000254235.3_Silent_p.D547D|ADCY7_ENST00000537579.1_Intron|ADCY7_ENST00000566433.2_Silent_p.D547D			P51828	ADCY7_HUMAN	adenylate cyclase 7	547					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding	p.D547D(1)		breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CGTACGATGACGAGATGCTGT	0.597000													18	179					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7295617	7295617	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:7295617A>T	ENST00000537408.1	+	10	2267	c.1729A>T	c.(1729-1731)Atg>Ttg	p.M577L	CLSTN3_ENST00000266546.6_Missense_Mutation_p.M565L			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	565					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						GGGCAAAGGCATGAAGGTATT	0.622000													8	47					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59113460	59113460	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:59113460G>A	ENST00000395153.3	+	4	2155	c.2008G>A	c.(2008-2010)Gcg>Acg	p.A670T	DACT1_ENST00000541264.2_Missense_Mutation_p.A426T|DACT1_ENST00000556859.1_Missense_Mutation_p.A426T|DACT1_ENST00000335867.4_Missense_Mutation_p.A707T	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	707					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						GCTGTACCCCGCGCCTGTGCC	0.672000													8	79					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109318494	109318494	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr13:109318494G>C	ENST00000356711.2	+	2	349	c.223G>C	c.(223-225)Gaa>Caa	p.E75Q	MYO16_ENST00000251041.5_Missense_Mutation_p.E75Q|MYO16_ENST00000357550.2_Missense_Mutation_p.E75Q	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	75					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CAATGACAAAGAAGGTACATG	0.418000													3	21					0	0	1	0	0
TXNIP	10628	broad.mit.edu	37	1	145440481	145440481	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:145440481T>C	ENST00000369317.4	+	5	1121	c.787T>C	c.(787-789)Tct>Cct	p.S263P	TXNIP_ENST00000475171.1_Intron	NM_006472.3	NP_006463.3	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	263					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	21	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GATCAGGCCTTCTATCCTGGG	0.493000													25	185					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167645734	167645734	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:167645734A>G	ENST00000519204.1	+	22	4593	c.4475A>G	c.(4474-4476)tAc>tGc	p.Y1492C	TENM2_ENST00000545108.1_Missense_Mutation_p.Y1612C|TENM2_ENST00000403607.2_Missense_Mutation_p.Y1437C|TENM2_ENST00000518659.1_Missense_Mutation_p.Y1613C|TENM2_ENST00000520394.1_Missense_Mutation_p.Y1374C					teneurin transmembrane protein 2																		ACAGGGGAGTACTTGTACAAT	0.473000													12	124					0	0	1	0	0
CLEC9A	283420	broad.mit.edu	37	12	10205299	10205299	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:10205299G>C	ENST00000355819.1	+	4	626	c.13G>C	c.(13-15)Gaa>Caa	p.E5Q	CLEC9A_ENST00000544751.1_3'UTR	NM_207345.2	NP_997228.1	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	5					positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	22						GCACGAGGAAGAAATATACAC	0.448000													11	61					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126240575	126240575	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:126240575C>T	ENST00000394329.3	+	1	3022	c.3009C>T	c.(3007-3009)gtC>gtT	p.V1003V		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1003	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CTTATGAAGTCACCCTTTCTG	0.408000													7	93					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140076196	140076196	+	Missense_Mutation	SNP	C	C	T	rs142080330		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:140076196C>T	ENST00000323927.2	-	7	1409	c.1405G>A	c.(1405-1407)Gac>Aac	p.D469N		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	469					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		TCCTCACTGTCCTGGCCTGTC	0.652000													5	45					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080154	152080154	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152080154C>T	ENST00000368804.1	-	2	5538	c.5539G>A	c.(5539-5541)Gcg>Acg	p.A1847T		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1847	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCCTCCGCCCGGTACTGC	0.572000													8	103					0	0	1	0	0
SPATA31D3	389762	broad.mit.edu	37	9	84562902	84562902	+	RNA	SNP	A	A	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:84562902A>T	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							TATGAAGCCCATATTAAATCT	0.433000													6	3					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85531742	85531742	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:85531742G>C	ENST00000393217.2	+	19	4385	c.4324G>C	c.(4324-4326)Gat>Cat	p.D1442H		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1442										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TTTTATATTTGATGAAGTAAG	0.284000													10	46					0	0	1	0	0
GLP2R	9340	broad.mit.edu	37	17	9729386	9729386	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:9729386G>C	ENST00000262441.5	+	1	519	c.6G>C	c.(4-6)aaG>aaC	p.K2N	GLP2R_ENST00000574745.1_Intron	NM_004246.1	NP_004237.1	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor	2					G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				endometrium(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	44					Glucagon recombinant(DB00040)	GGAAGATGAAGCTGGGATCGA	0.632000													6	26					0	0	1	0	0
APLP2	334	broad.mit.edu	37	11	130011399	130011399	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:130011399G>T	ENST00000263574.5	+	16	2038	c.1966G>T	c.(1966-1968)Gac>Tac	p.D656Y	APLP2_ENST00000338167.5_Missense_Mutation_p.D644Y|APLP2_ENST00000539648.1_Missense_Mutation_p.D444Y|APLP2_ENST00000345598.5_Missense_Mutation_p.D415Y|APLP2_ENST00000278756.7_Missense_Mutation_p.D654Y|APLP2_ENST00000528499.1_Missense_Mutation_p.D588Y|APLP2_ENST00000543137.1_Missense_Mutation_p.D551Y	NM_001642.2	NP_001633.1	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	656					G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TCAGGTCATTGACGAGACTCT	0.498000													17	43					1.02788e-11	1.11941e-11	1	1	0
TSPAN14	81619	broad.mit.edu	37	10	82269071	82269071	+	Silent	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:82269071C>A	ENST00000429989.3	+	5	517	c.294C>A	c.(292-294)atC>atA	p.I98I	TSPAN14_ENST00000481124.1_Intron|TSPAN14_ENST00000372156.1_Silent_p.I98I|TSPAN14_ENST00000341863.6_Intron|TSPAN14_ENST00000372164.3_Silent_p.I81I|TSPAN14_ENST00000372158.1_Silent_p.I98I	NM_030927.2	NP_112189.2	Q8NG11	TSN14_HUMAN	tetraspanin 14							integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7			Colorectal(32;0.229)			GTGGCACCATCGTGCTCATCT	0.617000													7	42					0.00198382	0.00202847	1	1	0
REG1A	5967	broad.mit.edu	37	2	79348757	79348757	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:79348757C>T	ENST00000233735.1	+	3	237	c.134C>T	c.(133-135)tCc>tTc	p.S45F		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	45	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						GCCTATCGCTCCTACTGCTAC	0.542000													10	480					0	0	1	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066950	46066950	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr21:46066950T>C	ENST00000334670.8	+	1	620	c.575T>C	c.(574-576)gTc>gCc	p.V192A	TSPEAR_ENST00000323084.4_Intron	NM_198692.2	NP_941965.2	P60411	KR109_HUMAN	keratin associated protein 10-11	186	25 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)	12						TGCGTGCCTGTCTGCTGCAAG	0.607000													31	399					0	0	1	0	0
KCNG2	26251	broad.mit.edu	37	18	77659423	77659423	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr18:77659423C>T	ENST00000316249.3	+	2	1008	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F	KCNG2_ENST00000590307.1_3'UTR	NM_012283.1	NP_036415.1	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G, member 2	336					energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity			breast(2)|endometrium(4)|lung(7)|skin(1)|upper_aerodigestive_tract(4)	18		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		TGGCGCTCTTCGCGCCACTGG	0.716000													5	11					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152084447	152084447	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152084447C>T	ENST00000368804.1	-	2	1245	c.1246G>A	c.(1246-1248)Gag>Aag	p.E416K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	416	8 X 6 AA tandem repeats of R-R-E-Q-Q-L.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			Agctgctgctcgcgcctcagc	0.711000													5	30					0	0	1	0	0
RPS18	6222	broad.mit.edu	37	6	33243657	33243657	+	Silent	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:33243657T>C	ENST00000439602.2	+	3	296	c.186T>C	c.(184-186)gaT>gaC	p.D62D	RPS18_ENST00000474973.1_5'UTR|RPS18_ENST00000476222.1_3'UTR			P62269	RS18_HUMAN	ribosomal protein S18	62					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome			kidney(2)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	9						TCACTGAGGATGAGGTGAGGA	0.567000													6	136					0	0	1	0	0
CPA6	57094	broad.mit.edu	37	8	68334769	68334769	+	Silent	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:68334769G>T	ENST00000297770.4	-	11	1499	c.1284C>A	c.(1282-1284)atC>atA	p.I428I	CPA6_ENST00000297769.4_Silent_p.I184I	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6	428					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			GGTGCATTGTGATATTTTTCA	0.453000													12	173					4.3838e-07	4.64683e-07	1	1	0
CDYL	9425	broad.mit.edu	37	6	4892403	4892403	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:4892403G>A	ENST00000328908.5	+	4	774	c.643G>A	c.(643-645)Gag>Aag	p.E215K	CDYL_ENST00000343762.5_Missense_Mutation_p.E29K|CDYL_ENST00000449732.2_Missense_Mutation_p.E29K|CDYL_ENST00000472453.1_Intron|CDYL_ENST00000397588.3_Missense_Mutation_p.E161K			Q9Y232	CDYL1_HUMAN	chromodomain protein, Y-like	215					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity			breast(2)|kidney(2)|large_intestine(9)|lung(13)|skin(1)|stomach(2)|urinary_tract(1)	30	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		CTTTCAGAGCGAGAGCCCTGA	0.602000													5	70					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784471	82784471	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:82784471A>G	ENST00000333891.9	-	2	1823	c.1486T>C	c.(1486-1488)Tca>Cca	p.S496P	PCLO_ENST00000423517.2_Missense_Mutation_p.S496P	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein		10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.|Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.S496P(6)|p.?(3)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGCTTTGCTGAGCCAGGCTGT	0.607000													11	238					0	0	1	0	0
CTNNB1	1499	broad.mit.edu	37	3	41278172	41278172	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:41278172T>A	ENST00000349496.5	+	13	2328	c.2048T>A	c.(2047-2049)tTc>tAc	p.F683Y	CTNNB1_ENST00000453024.1_Missense_Mutation_p.F676Y|CTNNB1_ENST00000396183.3_Missense_Mutation_p.F683Y|CTNNB1_ENST00000396185.3_Missense_Mutation_p.F683Y|CTNNB1_ENST00000405570.1_Missense_Mutation_p.F683Y	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	683					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	AGCTCTCTCTTCAGAACAGAG	0.458000		15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				11	158					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55755405	55755405	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:55755405T>C	ENST00000373955.1	-	21	3163	c.2872A>G	c.(2872-2874)Agt>Ggt	p.S958G	PCDH15_ENST00000320301.6_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395433.1_Intron|PCDH15_ENST00000395430.1_Intron|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000361849.3_Intron|PCDH15_ENST00000395432.2_Intron|PCDH15_ENST00000437009.1_Intron|PCDH15_ENST00000373957.3_Intron			Q96QU1	PCD15_HUMAN	protocadherin-related 15	749	Cadherin 9.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGCCTTCTACTTACAGGAGGG	0.388000										HNSCC(58;0.16)			5	47					0	0	1	0	0
MAP7D1	55700	broad.mit.edu	37	1	36640550	36640550	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:36640550C>T	ENST00000373151.2	+	6	1007	c.791C>T	c.(790-792)tCt>tTt	p.S264F	MAP7D1_ENST00000316156.4_Intron|MAP7D1_ENST00000373150.4_Missense_Mutation_p.S264F|MAP7D1_ENST00000474796.1_3'UTR	NM_018067.3	NP_060537.3	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	264						cytoplasm|spindle				breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	19		Myeloproliferative disorder(586;0.0393)				CACGTGGACTCTATAATCAAC	0.607000													4	36					0	0	1	0	0
ST5	6764	broad.mit.edu	37	11	8724142	8724142	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:8724142G>C	ENST00000534127.1	-	17	3082	c.2697C>G	c.(2695-2697)gtC>gtG	p.V899V	ST5_ENST00000313726.6_Silent_p.V899V|ST5_ENST00000526757.1_Silent_p.V479V|ST5_ENST00000357665.1_Silent_p.V899V|ST5_ENST00000530991.1_Silent_p.V371V|RPL27A_ENST00000531102.1_Intron|ST5_ENST00000530438.1_Silent_p.V479V|ST5_ENST00000526099.1_Silent_p.V412V|ST5_ENST00000534278.1_Silent_p.V90V	NM_005418.3	NP_005409.3	P78524	ST5_HUMAN	suppression of tumorigenicity 5	899	DENN.				positive regulation of ERK1 and ERK2 cascade		protein binding			NS(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(13)|liver(1)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	39				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CCACAAAAATGACCCGGCGCT	0.572000													6	89					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90262280	90262280	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:90262280C>G	ENST00000469640.2	+	14	1666	c.1291C>G	c.(1291-1293)Ctc>Gtc	p.L431V	DAPK1_ENST00000358077.5_Missense_Mutation_p.L431V|DAPK1_ENST00000491893.1_Missense_Mutation_p.L431V|DAPK1_ENST00000472284.1_Missense_Mutation_p.L431V|DAPK1_ENST00000408954.3_Missense_Mutation_p.L431V			P53355	DAPK1_HUMAN	death-associated protein kinase 1	431					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						CTTGAAATTTCTCAGTGAGAA	0.502000									Chronic Lymphocytic Leukemia, Familial Clustering of				13	69					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43868912	43868912	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:43868912G>A	ENST00000562955.1	+	2	92	c.92G>A	c.(91-93)cGc>cAc	p.R31H	SZT2_ENST00000372450.4_Missense_Mutation_p.R31H|SZT2_ENST00000310739.4_Missense_Mutation_p.R31H	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	31						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CGAAATGTTCGCCTGGCTTGG	0.493000													6	63					0	0	1	0	0
C20orf194	25943	broad.mit.edu	37	20	3270794	3270794	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:3270794G>C	ENST00000252032.9	-	26	2375	c.2308C>G	c.(2308-2310)Ctg>Gtg	p.L770V	C20orf194_ENST00000453730.2_Intron	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	770										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						TCCTTATGCAGAGTGACCAGA	0.478000													42	310					0	0	1	0	0
H3F3B	3021	broad.mit.edu	37	17	73774687	73774687	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:73774687C>G	ENST00000254810.4	-	4	532	c.400G>C	c.(400-402)Gag>Cag	p.E134Q	H3F3B_ENST00000592643.1_Missense_Mutation_p.E109D|H3F3B_ENST00000593254.1_5'UTR|H3F3B_ENST00000586607.1_Missense_Mutation_p.E134Q|H3F3B_ENST00000589599.1_Missense_Mutation_p.E134Q|H3F3B_ENST00000587560.1_Missense_Mutation_p.E134Q|H3F3B_ENST00000591890.1_3'UTR	NM_005324.3	NP_005315.1	P84243	H33_HUMAN	H3 histone, family 3B (H3.3B)	134					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			large_intestine(1)|lung(4)|ovary(2)|skin(1)	8	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			TAAGCTCTCTCTCCCCGTATC	0.418000													32	132					0	0	1	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37186312	37186312	+	RNA	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:37186312C>G	ENST00000425901.2	+	0	154					NR_033753.2																						GTAGAACCTTCTGCCACCCAG	0.532000													12	52					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10475384	10475384	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:10475384G>A	ENST00000525621.1	-	9	1754	c.1273C>T	c.(1273-1275)Cgc>Tgc	p.R425C	TYK2_ENST00000529370.1_Missense_Mutation_p.R425C|TYK2_ENST00000264818.6_Missense_Mutation_p.R425C|TYK2_ENST00000524462.1_Missense_Mutation_p.R240C	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	425	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GCCGTCAGGCGGAAATAGCCG	0.672000													22	79					0	0	1	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51628543	51628543	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:51628543G>A	ENST00000440804.3	+	1	379	c.312G>A	c.(310-312)ctG>ctA	p.L104L	SIGLEC9_ENST00000250360.3_Silent_p.L104L	NM_001198558.1	NP_001185487.1	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9	104	Ig-like V-type.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(3)|lung(25)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	45		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ATTGCACCCTGAGCATCAGAG	0.507000													19	115					0	0	1	0	0
ZNF551	90233	broad.mit.edu	37	19	58198725	58198725	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:58198725G>A	ENST00000282296.5	+	3	1267	c.1082G>A	c.(1081-1083)aGg>aAg	p.R361K	AC003006.7_ENST00000594684.1_Intron|ZNF551_ENST00000356715.4_Missense_Mutation_p.R345K|ZNF551_ENST00000596085.1_Intron|AC003006.7_ENST00000599221.1_Intron			Q7Z340	ZN551_HUMAN	zinc finger protein 551	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ACTGGAGAAAGGCCTTATGAA	0.468000													11	141					0	0	1	0	0
CCR5	1234	broad.mit.edu	37	3	46414768	46414768	+	Silent	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:46414768T>C	ENST00000343801.4	+	3	732	c.375T>C	c.(373-375)gaT>gaC	p.D125D	CCR5_ENST00000292303.4_Silent_p.D125D|RP11-24F11.2_ENST00000451485.1_RNA|CCR5_ENST00000445772.1_Silent_p.D125D	NM_000579.3	NP_000570.1	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5 (gene/pseudogene)	125					cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity	p.D125E(1)		central_nervous_system(1)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	TGACAATCGATAGGTACCTGG	0.478000													10	209					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145512562	145512562	+	Silent	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:145512562G>T	ENST00000394434.2	-	23	2461	c.2295C>A	c.(2293-2295)ctC>ctA	p.L765L	LARS_ENST00000545646.1_Silent_p.L719L|LARS_ENST00000274562.9_Silent_p.L738L|LARS_ENST00000510191.1_Silent_p.L711L	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	765					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TGTACAGACGGAGAATACCTG	0.478000													7	56					2.0095e-06	2.11596e-06	1	1	0
SGOL2	151246	broad.mit.edu	37	2	201436243	201436243	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:201436243G>A	ENST00000357799.4	+	7	1272	c.1174G>A	c.(1174-1176)Gaa>Aaa	p.E392K		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	392					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding	p.E392Q(1)		NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						AAAAACAAATGAACATGGAAT	0.318000													6	56					0	0	1	0	0
PFN1	5216	broad.mit.edu	37	17	4849269	4849269	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:4849269C>G	ENST00000225655.5	-	3	968	c.349G>C	c.(349-351)Gaa>Caa	p.E117Q	PFN1_ENST00000574872.1_Missense_Mutation_p.E81Q	NM_005022.3	NP_005013.1	P07737	PROF1_HUMAN	profilin 1	117					actin cytoskeleton organization|platelet activation|platelet degranulation	actin cytoskeleton|cytoplasm	actin binding|proline-rich region binding	p.E117Q(1)		NS(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5						TGGACACCTTCTTTGCCCATC	0.552000													15	65					0	0	1	0	0
LY6G5B	58496	broad.mit.edu	37	6	31639913	31639913	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:31639913G>C	ENST00000375864.4	+	3	1244	c.460G>C	c.(460-462)Gag>Cag	p.E154Q	CSNK2B-LY6G5B-1181_ENST00000375880.2_3'UTR|LY6G5B_ENST00000409525.1_Missense_Mutation_p.E99Q	NM_021221.2	NP_067044.2	Q8NDX9	LY65B_HUMAN	lymphocyte antigen 6 complex, locus G5B	154						extracellular region				lung(4)	4						TGCTGGGACGGAGCCTGATGG	0.587000													10	74					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57588794	57588794	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:57588794G>C	ENST00000243077.3	+	51	8684	c.8218G>C	c.(8218-8220)Gag>Cag	p.E2740Q		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2740	LDL-receptor class A 16.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGCCCAGTTTGAGTGCCAGAA	0.597000													13	154					0	0	1	0	0
PRR23B	389151	broad.mit.edu	37	3	138738765	138738765	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:138738765G>A	ENST00000329447.5	-	1	1003	c.739C>T	c.(739-741)Cgc>Tgc	p.R247C	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	247	Pro-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGCGGCGAGCGCGCGTGGGGA	0.657000													12	84					0	0	1	0	0
TMC6	11322	broad.mit.edu	37	17	76120607	76120607	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:76120607C>T	ENST00000590602.1	-	8	1048	c.889G>A	c.(889-891)Gcg>Acg	p.A297T	TMC6_ENST00000322914.3_Missense_Mutation_p.A297T|TMC6_ENST00000322933.4_5'UTR|TMC6_ENST00000392467.3_Missense_Mutation_p.A297T|TMC6_ENST00000589553.1_Missense_Mutation_p.A70T|TMC6_ENST00000306591.7_Missense_Mutation_p.A297T			Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	297						endoplasmic reticulum membrane|integral to membrane				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	14			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TTCCTCACCGCGCCTGTGAGG	0.697000													6	38					0	0	1	0	0
ALAD	210	broad.mit.edu	37	9	116152053	116152053	+	Splice_Site	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:116152053C>T	ENST00000409155.3	-	8	822	c.626G>A	c.(625-627)cGg>cAg	p.R209Q	ALAD_ENST00000277315.5_Splice_Site_p.R192Q	NM_000031.5	NP_000022.3	P13716	HEM2_HUMAN	aminolevulinate dehydratase	209					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding	p.R238Q(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|stomach(1)	9					Aminolevulinic acid(DB00855)	CCCTGCTCACCGGAAAGGGCC	0.562000													6	41					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861415	52861415	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:52861415C>T	ENST00000343457.3	-	4	1779	c.1773G>A	c.(1771-1773)atG>atA	p.M591I		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	591						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						CATGTGTTAGCATTTTACAGA	0.483000													13	172					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116633772	116633772	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:116633772C>T	ENST00000260210.4	-	4	556	c.533G>A	c.(532-534)aGg>aAg	p.R178K	BUD13_ENST00000375445.3_Missense_Mutation_p.R178K	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	178	Arg-rich.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		ACGGATCCTCCTGGGAGGAGA	0.582000													34	213					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98804557	98804557	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:98804557G>C	ENST00000477737.1	+	10	1635	c.1431G>C	c.(1429-1431)gaG>gaC	p.E477D	VWA3B_ENST00000435344.1_Missense_Mutation_p.E477D|VWA3B_ENST00000451075.2_Missense_Mutation_p.E327D	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	477										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GGTACAGTGAGAGAATCCACA	0.502000													20	95					0	0	1	0	0
KIAA1161	57462	broad.mit.edu	37	9	34372105	34372105	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:34372105C>T	ENST00000297625.7	-	2	960	c.735G>A	c.(733-735)ctG>ctA	p.L245L		NM_020702.3	NP_065753.2	Q6NSJ0	K1161_HUMAN	KIAA1161	279					carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds	p.L245L(1)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CTCGGTAGCTCAGCTCTGGCG	0.667000													4	57					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235972124	235972124	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:235972124G>A	ENST00000389794.3	-	5	2168	c.1994C>T	c.(1993-1995)tCa>tTa	p.S665L	LYST_ENST00000536965.1_Missense_Mutation_p.S665L|LYST_ENST00000389793.2_Missense_Mutation_p.S665L			Q99698	LYST_HUMAN	lysosomal trafficking regulator	665					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GGATAAACTTGAGGAGAGTTC	0.408000													5	70					0	0	1	0	0
NTS	4922	broad.mit.edu	37	12	86272159	86272159	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:86272159C>G	ENST00000256010.6	+	3	279	c.172C>G	c.(172-174)Ctg>Gtg	p.L58V	NTS_ENST00000551529.1_Intron	NM_006183.4	NP_006174.1	P30990	NEUT_HUMAN	neurotensin	58					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity			large_intestine(2)|lung(6)	8						GAAGATGACTCTGCTAAATGT	0.373000													11	133					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30584986	30584986	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:30584986C>T	ENST00000562532.2	+	3	1640	c.1466C>T	c.(1465-1467)gCg>gTg	p.A489V		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7							integral to membrane		p.A489E(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GGGGCCTCGGCGGGAGAGCGT	0.701000													4	86					0	0	1	0	0
BCL6B	255877	broad.mit.edu	37	17	6928501	6928501	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:6928501C>T	ENST00000293805.5	+	5	963	c.871C>T	c.(871-873)Cgg>Tgg	p.R291W		NM_181844.3	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B	291						nucleus	zinc ion binding			skin(1)	1						ACCCTCTGAACGGGCTCGTCC	0.557000													10	158					0	0	1	0	0
PLAG1	5324	broad.mit.edu	37	8	57079984	57079984	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:57079984C>T	ENST00000316981.3	-	5	800	c.321G>A	c.(319-321)ctG>ctA	p.L107L	PLAG1_ENST00000429357.2_Silent_p.L107L|PLAG1_ENST00000423799.2_Silent_p.L25L	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	107	Decreased nuclear import with localization in the nucleus but also in the cytoplasm.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GGTGATTCTTCAGATGATCTT	0.393000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								4	28					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8591788	8591788	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:8591788C>G	ENST00000338257.8	-	23	2773	c.2506G>C	c.(2506-2508)Gag>Cag	p.E836Q		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	836						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GCGGCATCCTCTTGGAGGATG	0.627000													5	63					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13712435	13712435	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:13712435C>T	ENST00000357447.2	-	17	1713	c.1345G>A	c.(1345-1347)Gat>Aat	p.D449N	FRMD4A_ENST00000378503.1_Missense_Mutation_p.D449N|FRMD4A_ENST00000358621.4_Missense_Mutation_p.D434N	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	449						cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						TTCTGTTCATCCAGTTTGAAG	0.498000													15	95					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235826288	235826288	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:235826288C>T	ENST00000389794.3	-	53	11532	c.11358G>A	c.(11356-11358)ttG>ttA	p.L3786L	LYST_ENST00000389793.2_Silent_p.L3786L|LYST_ENST00000473037.1_5'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3786					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTGGCTGTTTCAAGCGCTGCT	0.458000													9	118					0	0	1	0	0
TSPAN1	10103	broad.mit.edu	37	1	46650908	46650908	+	Silent	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:46650908T>C	ENST00000372003.1	+	8	1070	c.606T>C	c.(604-606)aaT>aaC	p.N202N	TSPAN1_ENST00000498443.1_3'UTR	NM_005727.3	NP_005718.2	O60635	TSN1_HUMAN	tetraspanin 1	202						integral to membrane|lysosomal membrane				kidney(1)|large_intestine(1)|lung(5)|ovary(1)	8	Acute lymphoblastic leukemia(166;0.155)	Medulloblastoma(700;0.00498)|all_neural(321;0.0212)				GTTGCTTCAATCAGCTTTTGT	0.537000													19	300					0	0	1	0	0
OSCAR	126014	broad.mit.edu	37	19	54598563	54598563	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:54598563C>G	ENST00000358375.4	-	5	760	c.715G>C	c.(715-717)Gtc>Ctc	p.V239L	OSCAR_ENST00000356532.3_Missense_Mutation_p.V243L|OSCAR_ENST00000351806.4_Missense_Mutation_p.V228L|OSCAR_ENST00000359649.4_3'UTR|OSCAR_ENST00000284648.6_3'UTR|OSCAR_ENST00000391761.1_3'UTR	NM_133169.3	NP_573399.2	Q8IYS5	OSCAR_HUMAN	osteoclast associated, immunoglobulin-like receptor	0						extracellular region|integral to membrane|plasma membrane	receptor activity			large_intestine(1)|skin(1)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)					GAGATGAGGACCAGCCCGGCC	0.697000													3	14					0	0	1	0	0
ARRDC2	27106	broad.mit.edu	37	19	18120728	18120728	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:18120728C>T	ENST00000379656.3	+	5	897	c.714C>T	c.(712-714)ctC>ctT	p.L238L	ARRDC2_ENST00000222250.4_Silent_p.L243L	NM_001025604.1	NP_001020775.1	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2											endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)	12						TGGCCAGCCTCGCGGGCGAGC	0.716000													8	96					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538457	4538457	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:4538457G>T	ENST00000306390.6	-	2	999	c.539C>A	c.(538-540)cCc>cAc	p.P180H	CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	180						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCCCGGGGGGCAGTTTCCG	0.622000													25	265					1.96895e-08	2.10817e-08	1	1	0
OR4L1	122742	broad.mit.edu	37	14	20528361	20528361	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:20528361C>T	ENST00000315683.1	+	1	158	c.158C>T	c.(157-159)tCa>tTa	p.S53L		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ACATGTAGGTCAACCCTTCAT	0.423000													4	125					0	0	1	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67221161	67221161	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:67221161G>T	ENST00000314586.6	-	5	1247	c.1007C>A	c.(1006-1008)gCc>gAc	p.A336D	EXOC3L1_ENST00000562887.1_Intron	NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	336	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						GTGCAGCAAGGCGAAGGCATC	0.627000													10	67					2.17888e-05	2.27175e-05	1	1	0
TOR1AIP1	26092	broad.mit.edu	37	1	179852011	179852011	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:179852011G>A	ENST00000606911.2	+	1	565	c.374G>A	c.(373-375)cGa>cAa	p.R125Q	TOR1AIP1_ENST00000271583.3_Missense_Mutation_p.R125Q|TOR1AIP1_ENST00000528443.2_Missense_Mutation_p.R125Q|TOR1AIP1_ENST00000435319.4_Missense_Mutation_p.R4Q			Q5JTV8	TOIP1_HUMAN	torsin A interacting protein 1							integral to membrane|nuclear inner membrane				breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	18						ATGAAGACGCGAAGGACTACC	0.587000													9	90					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31133898	31133898	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:31133898C>T	ENST00000452305.1	-	9	3012	c.2449G>A	c.(2449-2451)Gag>Aag	p.E817K	ZNF438_ENST00000442986.1_Missense_Mutation_p.E827K|ZNF438_ENST00000538351.2_Missense_Mutation_p.E778K|ZNF438_ENST00000331737.6_Missense_Mutation_p.E817K|ZNF438_ENST00000375311.1_Missense_Mutation_p.E391K|ZNF438_ENST00000361310.3_Missense_Mutation_p.E827K|ZNF438_ENST00000436087.2_Missense_Mutation_p.E827K|ZNF438_ENST00000444692.2_Missense_Mutation_p.E817K|ZNF438_ENST00000413025.1_Missense_Mutation_p.E827K	NM_001143770.1	NP_001137242.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	827					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E827K(1)|p.E827Q(1)		breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				TCTCATTTCTCAGCTTCACTG	0.512000													29	298					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71016176	71016176	+	Silent	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:71016176A>G	ENST00000334414.6	-	3	746	c.702T>C	c.(700-702)acT>acC	p.T234T	PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000551525.1_Silent_p.T233T|PTPRB_ENST00000550358.1_Silent_p.T234T	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0	Fibronectin type-III 3.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TTACCTCTTCAGTGGTGCTGG	0.507000													8	218					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100796630	100796630	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:100796630G>A	ENST00000358544.2	+	43	8053	c.7942G>A	c.(7942-7944)Gat>Aat	p.D2648N	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.D2623N	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2648					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGGCCAGGTGGATACTGATGA	0.468000													22	179					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28547168	28547168	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:28547168A>T	ENST00000452236.2	-	2	1066	c.449T>A	c.(448-450)gTt>gAt	p.V150D	SCAND3_ENST00000530247.1_5'UTR	NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	150					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						TTCCATAGAAACTTCCTGCCC	0.413000													12	93					0	0	1	0	0
DOC2A	8448	broad.mit.edu	37	16	30021406	30021406	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:30021406G>A	ENST00000350119.4	-	2	328	c.138C>T	c.(136-138)ggC>ggT	p.G46G	DOC2A_ENST00000564944.1_Silent_p.G46G|DOC2A_ENST00000564979.1_Silent_p.G46G	NM_001282062.1|NM_001282063.1|NM_001282068.1|NM_003586.2	NP_001268991.1|NP_001268992.1|NP_001268997.1|NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	46	Interaction with UNC13D and DYNLT1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						cgccgcccccgccgcccccTT	0.731000													8	60					0	0	1	0	0
FAM127B	26071	broad.mit.edu	37	X	134186001	134186001	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:134186001C>A	ENST00000370775.2	-	1	204	c.138G>T	c.(136-138)caG>caT	p.Q46H	FAM127B_ENST00000520964.1_5'UTR	NM_001078172.1	NP_001071640.1	Q9BWD3	F127B_HUMAN	family with sequence similarity 127, member B	46										breast(3)|endometrium(2)|large_intestine(3)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;0.000127)					AGGAGCTCGTCTGCACGATGA	0.652000													32	59					2.81731e-10	3.03697e-10	1	1	0
KLHDC8B	200942	broad.mit.edu	37	3	49211748	49211748	+	Silent	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:49211748T>C	ENST00000332780.2	+	3	662	c.453T>C	c.(451-453)cgT>cgC	p.R151R	KLHDC8B_ENST00000476495.2_3'UTR	NM_173546.2	NP_775817.1	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	151						cytoplasm				endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)|stomach(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ATGAGCCCCGTCGGGACTGCT	0.597000													10	117					0	0	1	0	0
ZNF329	79673	broad.mit.edu	37	19	58639742	58639742	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:58639742C>T	ENST00000598312.1	-	4	1362	c.1129G>A	c.(1129-1131)Ggg>Agg	p.G377R	ZNF329_ENST00000358067.4_Missense_Mutation_p.G377R	NM_024620.3	NP_078896.3	Q86UD4	ZN329_HUMAN	zinc finger protein 329	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(10)|lung(5)|skin(3)|urinary_tract(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		AAGGATTTCCCGCACTCTGCA	0.478000													12	137					0	0	1	0	0
KRTCAP3	200634	broad.mit.edu	37	2	27665507	27665507	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:27665507C>T	ENST00000543753.1	+	2	137	c.90C>T	c.(88-90)caC>caT	p.H30H	KRTCAP3_ENST00000288873.3_Silent_p.H30H|KRTCAP3_ENST00000407293.1_Silent_p.H12H	NM_001168364.1	NP_001161836.1	Q53RY4	KCP3_HUMAN	keratinocyte associated protein 3	30						integral to membrane				large_intestine(1)|lung(2)	3	Acute lymphoblastic leukemia(172;0.155)					TGGTGGGCCACGTGAACCTGC	0.711000													6	27					0	0	1	0	0
ZNF524	147807	broad.mit.edu	37	19	56113573	56113573	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:56113573G>A	ENST00000591046.1	+	1	329	c.95G>A	c.(94-96)cGa>cAa	p.R32Q	ZNF524_ENST00000301073.3_Missense_Mutation_p.R32Q			Q96C55	ZN524_HUMAN	zinc finger protein 524	32					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(2)|lung(6)|prostate(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CGGGGCCGCCGAGGCCGTCGT	0.682000													8	45					0	0	1	0	0
C3orf35	339883	broad.mit.edu	37	3	37476522	37476522	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:37476522C>T	ENST00000328376.5	+	6	1393	c.414C>T	c.(412-414)gcC>gcT	p.A138A	C3orf35_ENST00000481400.1_3'UTR	NM_178339.2	NP_848029.2	Q8IVJ8	APRG1_HUMAN	chromosome 3 open reading frame 35	138						integral to membrane				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|urinary_tract(1)	11						GTGGGGATGCCTGGAAAACAA	0.537000													4	49					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32560146	32560146	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:32560146C>T	ENST00000345122.3	+	2	586	c.271C>T	c.(271-273)Cat>Tat	p.H91Y	ARHGAP5_ENST00000556611.1_Missense_Mutation_p.H91Y|ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000432921.1_Missense_Mutation_p.H91Y|ARHGAP5_ENST00000539826.2_Missense_Mutation_p.H91Y|ARHGAP5_ENST00000396582.2_Intron	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	91					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		ATGCAAAATTCATGTCATTGA	0.373000													7	89					0	0	1	0	0
KIAA0895L	653319	broad.mit.edu	37	16	67213339	67213339	+	Nonsense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:67213339C>A	ENST00000290881.7	-	5	1767	c.841G>T	c.(841-843)Gag>Tag	p.E281*	KIAA0895L_ENST00000561621.1_Nonsense_Mutation_p.E281*|KIAA0895L_ENST00000563831.2_Intron|KIAA0895L_ENST00000563902.1_Nonsense_Mutation_p.E281*			Q68EN5	K895L_HUMAN	KIAA0895-like	281										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						TGACCTATCTCATGCCGCAGC	0.622000													13	121					3.52763e-06	3.70227e-06	1	1	0
GEMIN4	50628	broad.mit.edu	37	17	649462	649462	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:649462G>C	ENST00000576778.1	-	1	3129	c.1788C>G	c.(1786-1788)ctC>ctG	p.L596L	GEMIN4_ENST00000319004.5_Silent_p.L607L			P57678	GEMI4_HUMAN	gem (nuclear organelle) associated protein 4	607					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		CGGTTTCTTTGAGGCATGACA	0.502000													18	150					0	0	1	0	0
DNAJC16	23341	broad.mit.edu	37	1	15890478	15890478	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:15890478G>A	ENST00000375847.3	+	10	1557	c.1393G>A	c.(1393-1395)Gaa>Aaa	p.E465K	DNAJC16_ENST00000375838.1_Missense_Mutation_p.E465K|DNAJC16_ENST00000483270.1_3'UTR|DNAJC16_ENST00000375849.1_Missense_Mutation_p.E465K	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	465					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TAAAACCCTGGAAGACCCTTG	0.453000													24	206					0	0	1	0	0
FBXW7	55294	broad.mit.edu	37	4	153244185	153244185	+	Nonsense_Mutation	SNP	G	G	A	rs144247898		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:153244185G>A	ENST00000281708.4	-	12	3201	c.1972C>T	c.(1972-1974)Cga>Tga	p.R658*	FBXW7_ENST00000603548.1_Nonsense_Mutation_p.R658*|FBXW7_ENST00000603841.1_Nonsense_Mutation_p.R658*|FBXW7_ENST00000393956.3_Nonsense_Mutation_p.R482*|FBXW7_ENST00000296555.5_Nonsense_Mutation_p.R540*|FBXW7_ENST00000263981.5_Nonsense_Mutation_p.R578*	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	658					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R658*(3)|p.R578*(1)|p.?(1)|p.R419*(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ACTAGGTTTCGAATAAATTCA	0.473000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								8	121					0	0	1	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213415603	213415603	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:213415603C>T	ENST00000366960.3	+	11	2934	c.2784C>T	c.(2782-2784)cgC>cgT	p.R928R	RPS6KC1_ENST00000543470.1_Silent_p.R716R|RPS6KC1_ENST00000490299.1_3'UTR|RPS6KC1_ENST00000543354.1_Silent_p.R631R|RPS6KC1_ENST00000366959.3_Silent_p.R916R	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	928	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TTGTGTGCCGCGATTTGAACC	0.433000													9	102					0	0	1	0	0
FOXQ1	94234	broad.mit.edu	37	6	1313431	1313431	+	Silent	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:1313431C>A	ENST00000296839.2	+	1	757	c.492C>A	c.(490-492)cgC>cgA	p.R164R		NM_033260.3	NP_150285.3	Q9C009	FOXQ1_HUMAN	forkhead box Q1	164					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			lung(1)|urinary_tract(1)	2	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		CGGGCTGGCGCAACTCCGTGC	0.647000													9	92					0.000442599	0.000455491	1	1	0
MAML2	84441	broad.mit.edu	37	11	95724768	95724768	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:95724768C>G	ENST00000524717.1	-	3	3543	c.2259G>C	c.(2257-2259)ttG>ttC	p.L753F		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	753					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				TCTTTCCCATCAATTGCTGAT	0.488000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								19	109					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685907	125685907	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:125685907C>T	ENST00000371126.1	-	1	927	c.685G>A	c.(685-687)Gac>Aac	p.D229N		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	229										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						GCAACAGTGTCATCGAACTTG	0.637000													19	42					0	0	1	0	0
TCP11	6954	broad.mit.edu	37	6	35088699	35088699	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:35088699G>C	ENST00000311875.5	-	6	1158	c.741C>G	c.(739-741)ctC>ctG	p.L247L	TCP11_ENST00000412155.2_Silent_p.L196L|TCP11_ENST00000444780.2_Silent_p.L242L|TCP11_ENST00000512012.1_Silent_p.L234L|TCP11_ENST00000244645.3_Silent_p.L172L|TCP11_ENST00000373979.2_Silent_p.L172L|TCP11_ENST00000373974.4_Silent_p.L201L|TCP11_ENST00000418521.2_Silent_p.L171L			Q8WWU5	TCP11_HUMAN	t-complex 11, testis-specific	234					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|kidney(5)|large_intestine(3)|lung(10)|ovary(3)|prostate(1)|skin(4)	27						GCTGCTTATTGAGGAGTTCCT	0.423000													69	392					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10442706	10442706	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:10442706C>T	ENST00000397077.1	-	7	1287	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K	ATP2B2_ENST00000383800.4_Missense_Mutation_p.E238K|ATP2B2_ENST00000360273.2_Missense_Mutation_p.E238K|ATP2B2_ENST00000343816.4_Missense_Mutation_p.E238K|ATP2B2_ENST00000352432.4_Missense_Mutation_p.E238K			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	238					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						AGGGAGCTTTCATCAATCTTG	0.592000													17	84					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65246625	65246625	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:65246625G>C	ENST00000389722.3	-	20	4344	c.4291C>G	c.(4291-4293)Cga>Gga	p.R1431G	SPTB_ENST00000542895.1_Missense_Mutation_p.R1431G|SPTB_ENST00000389721.5_Missense_Mutation_p.R1431G|SPTB_ENST00000556626.1_Missense_Mutation_p.R1431G|SPTB_ENST00000389720.3_Missense_Mutation_p.R1431G	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1431					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TCCTCTTTTCGCACATTCACT	0.572000													10	125					0	0	1	0	0
FCGR2B	2213	broad.mit.edu	37	1	161641372	161641372	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:161641372C>T	ENST00000367962.4	+	3	451	c.324C>T	c.(322-324)agC>agT	p.S108S	FCGR2B_ENST00000403078.3_Silent_p.S108S|FCGR2B_ENST00000367960.5_Silent_p.S101S|FCGR2B_ENST00000367961.4_Silent_p.S101S|FCGR2B_ENST00000358671.5_Silent_p.S108S|FCGR2B_ENST00000236937.9_Silent_p.S108S|FCGR2B_ENST00000428605.2_Silent_p.S108S			P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor (CD32)	108	Ig-like C2-type 1.				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity					all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ACAATGACAGCGGGGAGTACA	0.592000			T	?	ALL								10	155					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45845616	45845616	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr21:45845616C>A	ENST00000397928.1	+	25	4146	c.3701C>A	c.(3700-3702)cCg>cAg	p.P1234Q	TRPM2_ENST00000300482.5_Missense_Mutation_p.P1234Q|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.P1214Q|TRPM2_ENST00000397932.2_Missense_Mutation_p.P1284Q	NM_003307.3	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1234						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						ACGGAGGAGCCGGGCGACAGC	0.677000													3	19					1	1	1	1	0
CALCR	799	broad.mit.edu	37	7	93067391	93067391	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:93067391G>T	ENST00000359558.2	-	13	1312	c.1013C>A	c.(1012-1014)cCt>cAt	p.P338H	CALCR_ENST00000394441.1_Missense_Mutation_p.P304H|CALCR_ENST00000426151.1_Missense_Mutation_p.P304H|CALCR_ENST00000421592.1_Missense_Mutation_p.P320H|CALCR_ENST00000360249.4_Missense_Mutation_p.P320H	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	320					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	CGCCATGACAGGTCCATGGAT	0.348000													6	46					0.217242	0.217928	1	1	0
MSLN	10232	broad.mit.edu	37	16	816647	816647	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:816647C>G	ENST00000382862.3	+	13	1329	c.1234C>G	c.(1234-1236)Cct>Gct	p.P412A	MSLN_ENST00000545450.2_Intron|MSLN_ENST00000566549.1_Intron|MSLN_ENST00000563941.1_Intron	NM_013404.4	NP_037536.2	Q13421	MSLN_HUMAN	mesothelin	412					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				CCACAAGGCTCCTCGGCGGCC	0.632000													16	104					0	0	1	0	0
C7orf50	84310	broad.mit.edu	37	7	1037332	1037332	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:1037332C>T	ENST00000397098.3	-	5	1440	c.514G>A	c.(514-516)Gag>Aag	p.E172K	C7orf50_ENST00000357429.6_Missense_Mutation_p.E172K|C7orf50_ENST00000488073.1_5'UTR|C7orf50_ENST00000397100.2_Missense_Mutation_p.E172K			Q9BRJ6	CG050_HUMAN	chromosome 7 open reading frame 50	172							protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		GAGCCCTCCTCATCCAGCTCC	0.711000													8	80					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411502	126411502	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:126411502G>A	ENST00000394329.3	+	17	13538	c.13525G>A	c.(13525-13527)Gtg>Atg	p.V4509M	FAT4_ENST00000335110.5_Missense_Mutation_p.V2750M	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4509					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCCTGCCATCGTGGGCAGCTG	0.577000													10	111					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29231581	29231581	+	RNA	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:29231581A>G	ENST00000441381.1	+	0	79																											CACAGCCACCAAAAGTGATTT	0.413000													33	263					0	0	1	0	0
PAX9	5083	broad.mit.edu	37	14	37145475	37145475	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:37145475C>T	ENST00000361487.6	+	4	1069	c.844C>T	c.(844-846)Caa>Taa	p.Q282*	PAX9_ENST00000557107.1_3'UTR|PAX9_ENST00000554201.1_Silent_p.P91P|PAX9_ENST00000402703.2_Nonsense_Mutation_p.Q282*			P55771	PAX9_HUMAN	paired box 9	282					multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(3)	12	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		TACCCCAGCCCAAGTGTCGCC	0.532000													13	111					0	0	1	0	0
CDK11B	984	broad.mit.edu	37	1	1572053	1572053	+	Silent	SNP	C	C	T	rs17424311		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:1572053C>T	ENST00000407249.3	-	18	1916	c.1917G>A	c.(1915-1917)aaG>aaA	p.K639K	CDK11B_ENST00000317673.7_Silent_p.K637K|CDK11B_ENST00000341832.6_Silent_p.K592K|CDK11B_ENST00000340677.5_Silent_p.K626K			P21127	CD11B_HUMAN	cyclin-dependent kinase 11B	649	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			endometrium(2)|large_intestine(3)|lung(4)|skin(1)|stomach(2)	12						CCTTGAACACCTTGTTGATCT	0.607000													7	64					0	0	1	0	0
CTRB2	440387	broad.mit.edu	37	16	75238191	75238191	+	Missense_Mutation	SNP	C	C	G	rs1130512		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:75238191C>G	ENST00000303037.8	-	7	703	c.660G>C	c.(658-660)caG>caC	p.Q220H		NM_001025200.3	NP_001020371.3	Q6GPI1	CTRB2_HUMAN	chymotrypsinogen B2	220	Peptidase S1.				digestion|proteolysis	extracellular space	serine-type endopeptidase activity			endometrium(1)|large_intestine(1)|lung(2)	4						CTCCGTCCTTCTGGCAGACCA	0.652000													4	84					0	0	1	0	0
GIGYF1	64599	broad.mit.edu	37	7	100281007	100281007	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:100281007G>C	ENST00000275732.5	-	18	3322	c.2113C>G	c.(2113-2115)Cga>Gga	p.R705G		NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	705										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TTCTCCTCTCGACGCTTGCGT	0.647000													27	245					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238516	3238516	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:3238516G>C	ENST00000217939.6	-	5	5364	c.5210C>G	c.(5209-5211)aCt>aGt	p.T1737S		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1737						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AAAAGAAAGAGTCTTGTTGGT	0.463000													24	28					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159409753	159409753	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:159409753C>A	ENST00000423932.3	+	1	242	c.205C>A	c.(205-207)Ccc>Acc	p.P69T	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	69					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TCTTCACACACCCATGTACTT	0.458000													9	160					1.12685e-05	1.17875e-05	1	1	0
FRMD3	257019	broad.mit.edu	37	9	85913693	85913693	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:85913693T>A	ENST00000304195.3	-	12	1246	c.1040A>T	c.(1039-1041)aAg>aTg	p.K347M	FRMD3_ENST00000376438.1_Missense_Mutation_p.K347M|FRMD3_ENST00000376434.1_Missense_Mutation_p.K153M	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	347						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						CCTCTGGATCTTGGAACTGGC	0.498000													7	61					0	0	1	0	0
WFDC3	140686	broad.mit.edu	37	20	44417657	44417657	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:44417657C>G	ENST00000243938.4	-	3	207	c.124G>C	c.(124-126)Gag>Cag	p.E42Q	WFDC3_ENST00000372632.2_Missense_Mutation_p.E42Q|WFDC3_ENST00000481847.1_Intron|WFDC3_ENST00000372630.2_Intron	NM_080614.1	NP_542181.1	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3	42	WAP 1.					extracellular region	serine-type endopeptidase inhibitor activity			endometrium(1)|large_intestine(3)|prostate(1)	5		Myeloproliferative disorder(115;0.0122)				TGGCACAGCTCTTTGCATGGG	0.512000													16	249					0	0	1	0	0
MYL2	4633	broad.mit.edu	37	12	111348892	111348892	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:111348892C>G	ENST00000228841.8	-	7	537	c.490G>C	c.(490-492)Gag>Cag	p.E164Q	MYL2_ENST00000548438.1_Missense_Mutation_p.E150Q	NM_000432.3	NP_000423.2	P10916	MLRV_HUMAN	myosin, light chain 2, regulatory, cardiac, slow	164	EF-hand 3.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	12						TAGTCCTTCTCTTCTCCGTGG	0.607000													15	122					0	0	1	0	0
DROSHA	29102	broad.mit.edu	37	5	31521263	31521263	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:31521263C>G	ENST00000511367.2	-	5	1158	c.914G>C	c.(913-915)aGg>aCg	p.R305T	DROSHA_ENST00000513349.1_Missense_Mutation_p.R305T|DROSHA_ENST00000442743.1_Missense_Mutation_p.R305T|DROSHA_ENST00000344624.3_Missense_Mutation_p.R305T	NM_013235.4	NP_037367.3	Q9NRR4	RNC_HUMAN	drosha, ribonuclease type III	305	Arg-rich.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(19)|lung(33)|ovary(2)|skin(1)	66						TTTGTAGGACCTTTCCAGAGA	0.408000													12	154					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53341818	53341818	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:53341818G>A	ENST00000398510.3	+	32	7093	c.7006G>A	c.(7006-7008)Gtg>Atg	p.V2336M	CHD9_ENST00000564845.1_Splice_Site|CHD9_ENST00000447540.1_Splice_Site|CHD9_ENST00000566029.1_Splice_Site			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2336	Binds A/T-rich DNA.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				GATGTCAAAGGTGAAGAAGCA	0.473000													4	38					0	0	1	0	0
BLOC1S5-TXNDC5	100526836	broad.mit.edu	37	6	8041460	8041460	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:8041460C>T	ENST00000439343.2	-	3	224	c.225G>A	c.(223-225)ttG>ttA	p.L75L	EEF1E1-BLOC1S5_ENST00000397456.2_3'UTR|BLOC1S5_ENST00000543936.1_Silent_p.L15L|BLOC1S5_ENST00000397457.2_Silent_p.L79L																							TCATGTTCTTCAAATTTTCAA	0.363000													10	58					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36766675	36766675	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:36766675G>A	ENST00000354618.5	+	10	2716	c.2492G>A	c.(2491-2493)cGa>cAa	p.R831Q	THRAP3_ENST00000469141.2_Missense_Mutation_p.R831Q	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	831					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGCAGAGCTCGAGGAACCTTT	0.502000			T	USP6	aneurysmal bone cysts								4	41					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1264405	1264405	+	Missense_Mutation	SNP	A	A	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:1264405A>C	ENST00000447027.1	+	31	6362	c.6304A>C	c.(6304-6306)Acc>Ccc	p.T2102P	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.T2099P			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2099	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			A -> P (in Ref. 4; CAA96577).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCGGGGACCACCCACACCGC	0.632000													7	20					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803646	142803646	+	RNA	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:142803646G>A	ENST00000423385.1	-	0	1319																											gttgtattctgggctagacat	0.299000													4	47					0	0	1	0	0
ZNF37A	7587	broad.mit.edu	37	10	38406754	38406754	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:38406754C>G	ENST00000361085.5	+	7	1020	c.675C>G	c.(673-675)agC>agG	p.S225R	ZNF37A_ENST00000351773.3_Missense_Mutation_p.S225R	NM_001178101.1|NM_003421.2	NP_001171572.1|NP_003412.1	P17032	ZN37A_HUMAN	zinc finger protein 37A							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						ACCCATTCAGCCAGAAGTTAA	0.348000													6	55					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29268244	29268244	+	Missense_Mutation	SNP	G	G	A	rs150801790		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:29268244G>A	ENST00000379558.4	+	19	3041	c.2690G>A	c.(2689-2691)cGt>cAt	p.R897H	FAM179A_ENST00000465300.1_3'UTR|FAM179A_ENST00000403861.2_Missense_Mutation_p.R842H	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	897							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CTGAGTGGCCGTGCGGTGCTG	0.612000													19	102					0	0	1	0	0
TAAR8	83551	broad.mit.edu	37	6	132874511	132874511	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:132874511C>A	ENST00000275200.1	+	1	680	c.680C>A	c.(679-681)gCt>gAt	p.A227D		NM_053278.1	NP_444508.1	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	227						plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		AAACAACAAGCTATAAAAATT	0.358000													11	77					3.86212e-05	4.0005e-05	1	1	0
NAE1	8883	broad.mit.edu	37	16	66860670	66860670	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:66860670G>A	ENST00000379463.2	-	3	241	c.49C>T	c.(49-51)Cat>Tat	p.H17Y	NAE1_ENST00000564040.2_5'UTR|NAE1_ENST00000394074.2_Intron|NAE1_ENST00000359087.4_Missense_Mutation_p.H23Y|NAE1_ENST00000290810.3_Missense_Mutation_p.H23Y	NM_001018159.1	NP_001018169.1	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1	23					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	TCTTGCCCATGATCACCCCAC	0.358000													10	84					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457832	45457832	+	RNA	SNP	A	A	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:45457832A>C	ENST00000548424.1	+	0	448																											GGCTTTGTTTAGGCGAAAGGT	0.463000													8	119					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861829	52861829	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:52861829C>T	ENST00000343457.3	-	4	1365	c.1359G>A	c.(1357-1359)gaG>gaA	p.E453E		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	453						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						GGGTCTGGTTCTCGTAGAGGC	0.542000													11	115					0	0	1	0	0
PPARG	5468	broad.mit.edu	37	3	12447544	12447544	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:12447544G>C	ENST00000397026.2	+	7	1100	c.717G>C	c.(715-717)gcG>gcC	p.A239A	PPARG_ENST00000397010.2_Silent_p.A233A|PPARG_ENST00000397000.1_Silent_p.A233A|PPARG_ENST00000287820.6_Silent_p.A261A|PPARG_ENST00000397015.2_Silent_p.A233A|PPARG_ENST00000539812.1_Silent_p.A231A|PPARG_ENST00000397012.2_Silent_p.A233A|PPARG_ENST00000309576.6_Silent_p.A233A			P37231	PPARG_HUMAN	peroxisome proliferator-activated receptor gamma	261	Interaction with FAM120B (By similarity).				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding		PAX8/PPARG(117)	breast(2)|endometrium(4)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	AAGCAAAGGCGAGGGCGATCT	0.478000			T	PAX8	follicular thyroid		"""Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension"""						9	53					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50720031	50720031	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr22:50720031C>G	ENST00000449103.1	-	21	3626	c.3486G>C	c.(3484-3486)caG>caC	p.Q1162H	PLXNB2_ENST00000359337.4_Missense_Mutation_p.Q1162H			O15031	PLXB2_HUMAN	plexin B2	1162					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGTCTCGTTTCTGCCGCCGCT	0.697000													16	77					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73824054	73824054	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:73824054C>T	ENST00000207549.4	-	32	3644	c.3265G>A	c.(3265-3267)Gca>Aca	p.A1089T	UNC13D_ENST00000412096.2_Intron	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	1089					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGCTACGGTGCCGGCCGCAAG	0.697000									Familial Hemophagocytic Lymphohistiocytosis				3	24					0	0	1	0	0
LONRF2	164832	broad.mit.edu	37	2	100903525	100903525	+	Splice_Site	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:100903525C>T	ENST00000393437.3	-	11	2560	c.1921G>A	c.(1921-1923)Gtg>Atg	p.V641M	LONRF2_ENST00000409647.1_Splice_Site_p.V398M	NM_198461.3	NP_940863.3	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger 2	641	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	34						GGACCCTCCACCTGATCAGGG	0.507000													5	41					0	0	1	0	0
PPCS	79717	broad.mit.edu	37	1	42922346	42922346	+	Missense_Mutation	SNP	T	T	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:42922346T>G	ENST00000372561.3	+	1	117	c.110T>G	c.(109-111)gTg>gGg	p.V37G	PPCS_ENST00000472013.1_3'UTR|PPCS_ENST00000372562.1_Intron|PPCS_ENST00000372560.3_Missense_Mutation_p.V37G|PPCS_ENST00000455780.1_Intron|PPCS_ENST00000372556.3_Intron	NM_024664.2	NP_078940.2	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase	37					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|skin(3)	12	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGCCGGCGGGTGGTGTTGGTT	0.711000													10	35					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058166	11058166	+	RNA	SNP	T	T	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr21:11058166T>A	ENST00000470054.1	-	0	481									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTACATCTTTCAGGAGCTTG	0.383000													7	65					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75116424	75116424	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:75116424G>C	ENST00000290573.2	+	17	3028	c.2428G>C	c.(2428-2430)Gag>Cag	p.E810Q	HK2_ENST00000409174.1_Missense_Mutation_p.E782Q	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	810	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						CTTAGGGCTTGAGAGCACCTG	0.617000													8	44					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10089628	10089628	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:10089628C>A	ENST00000287647.3	+	16	1399	c.1306C>A	c.(1306-1308)Ctg>Atg	p.L436M	FANCD2_ENST00000383806.1_Missense_Mutation_p.L436M|FANCD2_ENST00000383807.1_Missense_Mutation_p.L436M|FANCD2_ENST00000419585.1_Missense_Mutation_p.L436M	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	436					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TTCATCCATTCTGTCGCTGGC	0.393000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				26	255					5.45024e-15	5.97647e-15	1	1	0
MAGI1	9223	broad.mit.edu	37	3	65365145	65365145	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:65365145C>T	ENST00000330909.8	-	18	2869	c.2870G>A	c.(2869-2871)cGc>cAc	p.R957H	MAGI1_ENST00000497477.2_Missense_Mutation_p.R929H|MAGI1_ENST00000402939.2_Missense_Mutation_p.R929H|MAGI1_ENST00000483466.1_Missense_Mutation_p.R957H	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	957					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CTGCGGAGTGCGCTTCTCTTC	0.667000													16	121					0	0	1	0	0
OPN1LW	5956	broad.mit.edu	37	X	153420214	153420214	+	Splice_Site	SNP	G	G	A	rs139583770		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:153420214G>A	ENST00000369951.4	+	4	804	c.744G>A	c.(742-744)gcG>gcA	p.A248A	OPN1LW_ENST00000463296.1_Intron	NM_020061.4	NP_064445.2	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	248					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity	p.A248A(2)		endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	15	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCATCCGAGCGGTAAGCCCCC	0.547000													12	62					0	0	1	0	0
PRAMEF7	441871	broad.mit.edu	37	1	12979810	12979810	+	Silent	SNP	C	C	T	rs144939857		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:12979810C>T	ENST00000361079.2	+	4	1085	c.1002C>T	c.(1000-1002)ttC>ttT	p.F334F						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGACCCATTTCAGCCCTGAGC	0.577000													11	219					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203681223	203681223	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:203681223G>C	ENST00000357681.5	+	13	3290	c.2167G>C	c.(2167-2169)Gaa>Caa	p.E723Q	ATP2B4_ENST00000367219.3_Missense_Mutation_p.E711Q|ATP2B4_ENST00000391954.2_Missense_Mutation_p.E723Q|ATP2B4_ENST00000341360.2_Missense_Mutation_p.E723Q|ATP2B4_ENST00000367218.3_Missense_Mutation_p.E723Q	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	723					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCTGTGCTTAGAAGGCAAAGA	0.542000													9	81					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86869502	86869502	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:86869502A>G	ENST00000373119.4	+	3	801	c.656A>G	c.(655-657)aAa>aGa	p.K219R	KLHL4_ENST00000373114.4_Missense_Mutation_p.K219R	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	219	BTB.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						CTTGAAGCCAAACAAGAAGAG	0.378000													5	40					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34420399	34420399	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:34420399G>C	ENST00000374789.3	-	23	3866	c.3541C>G	c.(3541-3543)Caa>Gaa	p.Q1181E	PARD3_ENST00000346874.4_Missense_Mutation_p.Q1144E|PARD3_ENST00000545693.1_Missense_Mutation_p.Q1165E|PARD3_ENST00000545260.1_Missense_Mutation_p.Q1091E|PARD3_ENST00000374788.3_Missense_Mutation_p.Q1178E|PARD3_ENST00000350537.4_Missense_Mutation_p.Q1135E|PARD3_ENST00000374790.3_Missense_Mutation_p.Q1121E|PARD3_ENST00000374794.3_Missense_Mutation_p.Q1069E	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1181					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				ACCCAGGGTTGCTCAAAACTA	0.463000													15	57					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78922181	78922181	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:78922181C>G	ENST00000261751.3	-	5	577	c.466G>C	c.(466-468)Gag>Cag	p.E156Q	CHRNB4_ENST00000412074.2_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	156					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						TACTTCACCTCAATCTTGCAG	0.567000													11	74					0	0	1	0	0
CAMTA2	23125	broad.mit.edu	37	17	4876139	4876139	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:4876139C>G	ENST00000361571.5	-	14	2836	c.2425G>C	c.(2425-2427)Gag>Cag	p.E809Q	CAMTA2_ENST00000348066.3_Missense_Mutation_p.E810Q|CAMTA2_ENST00000358183.4_Missense_Mutation_p.E810Q|CAMTA2_ENST00000381311.5_Missense_Mutation_p.E812Q|CAMTA2_ENST00000414043.3_Missense_Mutation_p.E833Q|CAMTA2_ENST00000572543.1_Missense_Mutation_p.E815Q	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	810					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						TGTAGTTCCTCAAGGCAGCGG	0.612000													50	164					0	0	1	0	0
PTPN21	11099	broad.mit.edu	37	14	88934487	88934487	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:88934487G>C	ENST00000556564.1	-	19	3803	c.3519C>G	c.(3517-3519)ctC>ctG	p.L1173L	PTPN21_ENST00000328736.3_Silent_p.L1173L	NM_007039.3	NP_008970.2	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type 21	1173						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						GAGCTTAGATGAGCCTGGAGC	0.468000													39	247					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140074639	140074639	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:140074639C>G	ENST00000323927.2	-	10	1888	c.1884G>C	c.(1882-1884)caG>caC	p.Q628H		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	628					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		GTACCTTGAGCTGCTCATACT	0.632000													5	38					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170055326	170055326	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:170055326C>G	ENST00000263816.3	-	45	8833	c.8548G>C	c.(8548-8550)Gat>Cat	p.D2850H		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2850	LDL-receptor class A 19.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCACTGTTATCTCCACAGTCA	0.378000													3	38					0	0	1	0	0
MYL2	4633	broad.mit.edu	37	12	111348888	111348888	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:111348888T>C	ENST00000228841.8	-	7	541	c.494A>G	c.(493-495)aAg>aGg	p.K165R	MYL2_ENST00000548438.1_Missense_Mutation_p.K151R	NM_000432.3	NP_000423.2	P10916	MLRV_HUMAN	myosin, light chain 2, regulatory, cardiac, slow	165	EF-hand 3.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	12						CTCCTAGTCCTTCTCTTCTCC	0.602000													16	119					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13712504	13712504	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:13712504C>T	ENST00000357447.2	-	17	1644	c.1276G>A	c.(1276-1278)Gaa>Aaa	p.E426K	FRMD4A_ENST00000378503.1_Missense_Mutation_p.E426K|FRMD4A_ENST00000358621.4_Missense_Mutation_p.E411K	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	426						cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						AGGGGATATTCTACTGGCAGC	0.512000													15	110					0	0	1	0	0
FBXO39	162517	broad.mit.edu	37	17	6683806	6683806	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:6683806C>T	ENST00000321535.4	+	2	749	c.619C>T	c.(619-621)Cac>Tac	p.H207Y		NM_153230.2	NP_694962.1	Q8N4B4	FBX39_HUMAN	F-box protein 39	207										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	26						TTTCAGCCATCACCTTGCTGT	0.493000													15	81					0	0	1	0	0
CTRB2	440387	broad.mit.edu	37	16	75238187	75238187	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:75238187C>T	ENST00000303037.8	-	7	707	c.664G>A	c.(664-666)Gac>Aac	p.D222N		NM_001025200.3	NP_001020371.3	Q6GPI1	CTRB2_HUMAN	chymotrypsinogen B2	222	Peptidase S1.				digestion|proteolysis	extracellular space	serine-type endopeptidase activity			endometrium(1)|large_intestine(1)|lung(2)	4						CAGGCTCCGTCCTTCTGGCAG	0.652000													6	87					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332492	22332492	+	RNA	SNP	A	A	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:22332492A>C	ENST00000558896.1	+	0	299																											TATTTCTCTTATTACTATTTT	0.383000													5	228					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1019074	1019074	+	Missense_Mutation	SNP	A	A	T	rs77570255		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:1019074A>T	ENST00000398484.2	+	8	2034	c.1454A>T	c.(1453-1455)cAc>cTc	p.H485L	FGFRL1_ENST00000510644.1_Missense_Mutation_p.H485L|FGFRL1_ENST00000264748.6_Missense_Mutation_p.H485L|FGFRL1_ENST00000504138.1_Missense_Mutation_p.H485L			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	485	His-rich.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			acacacacacactctcacaca	0.607000													3	16					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112358447	112358447	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:112358447C>T	ENST00000206423.3	-	2	1259	c.306G>A	c.(304-306)gtG>gtA	p.V102V	CCDC80_ENST00000475181.1_5'UTR|CCDC80_ENST00000439685.2_Silent_p.V102V	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	102								p.V102V(1)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						GCTCAGGTCTCACGGCGGCCC	0.607000													25	135					0	0	1	0	0
CAND2	23066	broad.mit.edu	37	3	12861592	12861592	+	Silent	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:12861592A>G	ENST00000456430.2	+	11	2993	c.2952A>G	c.(2950-2952)ccA>ccG	p.P984P	CAND2_ENST00000295989.5_Silent_p.P891P	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	984					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CAGGTCGGCCACACACCCGGA	0.597000													14	106					0	0	1	0	0
C6orf15	29113	broad.mit.edu	37	6	31079947	31079947	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:31079947G>A	ENST00000259870.3	-	2	192	c.189C>T	c.(187-189)ccC>ccT	p.P63P		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	63										endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						GGTCCAGAGCGGGCTGCGGAT	0.562000													18	141					0	0	1	0	0
WDR70	55100	broad.mit.edu	37	5	37727078	37727078	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:37727078G>A	ENST00000265107.4	+	17	1964	c.1808G>A	c.(1807-1809)cGg>cAg	p.R603Q		NM_018034.2	NP_060504.1	Q9NW82	WDR70_HUMAN	WD repeat domain 70	603										central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTAATCCTCGGGAAGCCATT	0.463000													8	91					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200946381	200946381	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:200946381G>A	ENST00000332129.2	-	30	4561	c.4245C>T	c.(4243-4245)taC>taT	p.Y1415Y	KIF21B_ENST00000422435.2_Silent_p.Y1428Y|KIF21B_ENST00000360529.5_Silent_p.Y1415Y|KIF21B_ENST00000461742.2_Silent_p.Y1428Y	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1428					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CCGAGGCGGCGTACAGCATGG	0.642000													4	150					0	0	1	0	0
TMEM181	57583	broad.mit.edu	37	6	159046150	159046150	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:159046150C>T	ENST00000367090.3	+	12	1391	c.1380C>T	c.(1378-1380)ttC>ttT	p.F460F		NM_020823.1	NP_065874.1	Q9P2C4	TM181_HUMAN	transmembrane protein 181	460					pathogenesis	integral to membrane	toxin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)	22		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		TGAAGGTCTTCTTCATGGTGG	0.547000													8	153					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50696937	50696937	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:50696937G>C	ENST00000008391.3	+	5	1023	c.795G>C	c.(793-795)ctG>ctC	p.L265L	TFAP2D_ENST00000492804.1_3'UTR	NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	265							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					GCCGCTGCCTGAGAGAGAAAT	0.408000													13	124					0	0	1	0	0
TPST1	8460	broad.mit.edu	37	7	65705842	65705842	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:65705842G>A	ENST00000304842.5	+	2	855	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	TPST1_ENST00000480281.1_Intron	NM_003596.3	NP_003587.1	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	144					inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			NS(1)|biliary_tract(1)|breast(1)|kidney(3)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						CTTCTTACTAGAAATTATCGT	0.438000													4	86					0	0	1	0	0
SMCO1	255798	broad.mit.edu	37	3	196234952	196234952	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:196234952C>T	ENST00000397537.2	-	3	607	c.451G>A	c.(451-453)Gaa>Aaa	p.E151K		NM_001077657.1	NP_001071125.1			single-pass membrane protein with coiled-coil domains 1																		GTATAGTGTTCTGCCTTGTTA	0.463000													13	105					0	0	1	0	0
CCDC9	26093	broad.mit.edu	37	19	47773835	47773835	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:47773835G>A	ENST00000221922.6	+	10	1197	c.975G>A	c.(973-975)ccG>ccA	p.P325P		NM_015603.2	NP_056418.1	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	325										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|urinary_tract(1)	12		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		CCCGGCCCCCGAAGCCCCCTA	0.642000													9	109					0	0	1	0	0
AP3M2	10947	broad.mit.edu	37	8	42023048	42023048	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:42023048G>T	ENST00000518421.1	+	7	1064	c.773G>T	c.(772-774)cGc>cTc	p.R258L	AP3M2_ENST00000520685.1_Intron|AP3M2_ENST00000396926.3_Missense_Mutation_p.R258L|AP3M2_ENST00000174653.3_Missense_Mutation_p.R258L|AP3M2_ENST00000517922.1_Missense_Mutation_p.R258L	NM_001134296.1	NP_001127768.1	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	258	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus				endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|prostate(1)|stomach(1)	17	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			GGAAACTTCCGCCTGCTGTCT	0.463000													14	216					2.61681e-11	2.83043e-11	1	1	0
PLIN2	123	broad.mit.edu	37	9	19119764	19119764	+	Nonsense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:19119764C>A	ENST00000276914.2	-	6	840	c.661G>T	c.(661-663)Gga>Tga	p.G221*	PLIN2_ENST00000411567.1_Intron	NM_001122.3	NP_001113.2	Q99541	PLIN2_HUMAN	perilipin 2	221					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle		p.G221*(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	19						GACAGGGATCCCAGTCTAACA	0.413000													8	140					7.48243e-07	7.90502e-07	1	1	0
IGJ	3512	broad.mit.edu	37	4	71527924	71527924	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:71527924C>T	ENST00000254801.4	-	2	242	c.73G>A	c.(73-75)Gat>Aat	p.D25N	IGJ_ENST00000543780.1_Missense_Mutation_p.D41N|ENAM_ENST00000472903.1_3'UTR	NM_144646.3	NP_653247.1	P01591	IGJ_HUMAN	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	25					immune response	extracellular region	antigen binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7			Lung(101;0.235)			ATCCTTTCATCTTCTTGGGCT	0.358000													11	68					0	0	1	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95170811	95170811	+	Nonsense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:95170811G>T	ENST00000354268.4	+	7	785	c.712G>T	c.(712-714)Gaa>Taa	p.E238*	SMARCAD1_ENST00000457823.2_Nonsense_Mutation_p.E238*			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	238					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TTAGGGAGAGGAATCAAATGA	0.323000													8	44					1.06961e-07	1.13758e-07	1	1	0
ZNF846	162993	broad.mit.edu	37	19	9868414	9868414	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:9868414C>T	ENST00000397902.2	-	6	1752	c.1339G>A	c.(1339-1341)Gaa>Aaa	p.E447K	ZNF846_ENST00000586293.1_3'UTR|ZNF846_ENST00000592859.1_Intron|ZNF846_ENST00000588267.1_Intron	NM_001077624.1	NP_001071092.1	Q147U1	ZN846_HUMAN	zinc finger protein 846	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22						CAGGCCTTTTCTCCAGTGTGA	0.438000													17	69					0	0	1	0	0
PLIN2	123	broad.mit.edu	37	9	19121087	19121087	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:19121087G>A	ENST00000276914.2	-	5	565	c.386C>T	c.(385-387)tCt>tTt	p.S129F	PLIN2_ENST00000411567.1_Missense_Mutation_p.S129F	NM_001122.3	NP_001113.2	Q99541	PLIN2_HUMAN	perilipin 2	129					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	19						GCTGGCCACAGAATCCTTGGC	0.532000													7	72					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77672741	77672741	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr13:77672741G>C	ENST00000407578.2	-	56	8814	c.8548C>G	c.(8548-8550)Cta>Gta	p.L2850V	MYCBP2_ENST00000360084.5_Missense_Mutation_p.L335V|MYCBP2_ENST00000482517.1_5'UTR|MYCBP2_ENST00000357337.6_Missense_Mutation_p.L2812V|MYCBP2_ENST00000544440.2_Missense_Mutation_p.L2812V	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	2812					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTTTGAGGTAGATTTTTATCA	0.473000													8	116					0	0	1	0	0
EIF5AL1	143244	broad.mit.edu	37	10	81272751	81272751	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:81272751G>A	ENST00000520547.2	+	1	395	c.346G>A	c.(346-348)Gag>Aag	p.E116K		NM_001099692.1	NP_001093162.1	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like 1	116					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity			endometrium(1)	1	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TCGTCTCCCTGAGGGAGACCT	0.537000													6	154					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57335705	57335705	+	Silent	SNP	G	G	T	rs141346770	by1000genomes	TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:57335705G>T	ENST00000326441.9	-	4	682	c.319C>A	c.(319-321)Cga>Aga	p.R107R	ZIM2_ENST00000593711.1_5'UTR|ZIM2_ENST00000221722.5_5'UTR|ZIM2_ENST00000599935.1_5'UTR|PEG3_ENST00000423103.2_Silent_p.R107R|PEG3_ENST00000594706.1_5'UTR|PEG3_ENST00000593695.1_5'UTR|ZIM2_ENST00000391708.3_5'UTR|PEG3_ENST00000598410.1_5'UTR|ZIM2_ENST00000601070.1_5'UTR	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	107	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTTTTTGCTCGCACCCAAGGC	0.537000													13	154					0.00136819	0.0014035	1	1	0
FUK	197258	broad.mit.edu	37	16	70513198	70513198	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:70513198C>T	ENST00000288078.6	+	23	3277	c.3045C>T	c.(3043-3045)caC>caT	p.H1015H	FUK_ENST00000378912.2_Silent_p.H1021H|FUK_ENST00000571514.1_Silent_p.H506H	NM_145059.2	NP_659496.2	Q8N0W3	FUK_HUMAN	fucokinase	1015						cytoplasm	ATP binding|fucokinase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(11)|ovary(2)|prostate(2)	23		Ovarian(137;0.0694)				TGGCCCCCCACGTGCATGGCC	0.632000													4	75					0	0	1	0	0
DDHD1	80821	broad.mit.edu	37	14	53513571	53513571	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:53513571G>A	ENST00000357758.3	-	12	2717	c.2534C>T	c.(2533-2535)tCc>tTc	p.S845F	DDHD1_ENST00000395606.1_Missense_Mutation_p.S852F|DDHD1_ENST00000323669.5_Missense_Mutation_p.S873F	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	873	DDHD.				lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					AACATCCAAGGATGACCAATA	0.433000													11	65					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77600062	77600062	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:77600062G>A	ENST00000461745.1	+	8	2053	c.1153G>A	c.(1153-1155)Gac>Aac	p.D385N	ROBO2_ENST00000332191.8_Missense_Mutation_p.D385N|ROBO2_ENST00000487694.3_Missense_Mutation_p.D401N	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	385	Ig-like C2-type 4.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TCAACGTTCCGACGCGGGTTA	0.473000													7	74					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102518935	102518935	+	Splice_Site	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:102518935G>A	ENST00000321521.9	+	25	3496	c.2923G>A	c.(2923-2925)Gaa>Aaa	p.E975K	PPIP5K2_ENST00000358359.3_Splice_Site_p.E975K|PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000414217.1_Splice_Site_p.E975K			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	975					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TCACTTCCAGGAAGAGAGCCC	0.443000													6	36					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57347200	57347200	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:57347200G>C	ENST00000361249.3	+	5	643	c.547G>C	c.(547-549)Ggg>Cgg	p.G183R		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	183	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GGTATACAATGGGGAATGGAG	0.463000													8	133					0	0	1	0	0
DNAJC16	23341	broad.mit.edu	37	1	15894475	15894475	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:15894475G>A	ENST00000375847.3	+	15	2316	c.2152G>A	c.(2152-2154)Gaa>Aaa	p.E718K	DNAJC16_ENST00000483270.1_3'UTR|DNAJC16_ENST00000375849.1_Intron	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	718	Poly-Glu.				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AAAGACAGTCGAAGAGGAGGA	0.498000													11	96					0	0	1	0	0
TBX19	9095	broad.mit.edu	37	1	168250420	168250420	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:168250420G>C	ENST00000367821.3	+	1	143	c.92G>C	c.(91-93)aGg>aCg	p.R31T		NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	31					anatomical structure morphogenesis	nucleus	DNA binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					CAGGCAGGGAGGGAAAAAGGC	0.532000													10	188					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75902129	75902129	+	Splice_Site	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:75902129G>A	ENST00000274364.6	+	12	1654		c.e12+1		IQGAP2_ENST00000379730.3_Splice_Site	NM_006633.2	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2						small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GAAAATGACCGTAAGTATAAG	0.348000													3	35					0	0	1	0	0
CXCR5	643	broad.mit.edu	37	11	118754653	118754653	+	Translation_Start_Site	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:118754653G>T	ENST00000292174.4	+	1	179	c.3G>T	c.(1-3)atG>atT	p.M1I		NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	1					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GCACAGCCATGAACTACCCGC	0.577000													4	16					0.00909568	0.00918231	1	1	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													5	73					0	0	1	0	0
RXRA	6256	broad.mit.edu	37	9	137328331	137328331	+	Silent	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:137328331C>G	ENST00000540193.1	+	9	1892	c.969C>G	c.(967-969)ctC>ctG	p.L323L	RXRA_ENST00000481739.1_Silent_p.L420L|RXRA_ENST00000356384.4_3'UTR			P19793	RXRA_HUMAN	retinoid X receptor, alpha	420	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding	p.L420L(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	AGCTCTTGCTCCGCCTGCCGG	0.612000													9	144					0	0	1	0	0
XYLT2	64132	broad.mit.edu	37	17	48431297	48431297	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:48431297G>C	ENST00000017003.2	+	2	491	c.442G>C	c.(442-444)Gag>Cag	p.E148Q	XYLT2_ENST00000507602.1_Missense_Mutation_p.E148Q	NM_022167.2	NP_071450.2	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	148					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(2)|urinary_tract(1)	12	Breast(11;7.18e-19)					AGGGAGCGTGGAGGGCGCCCC	0.692000													9	47					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39448824	39448824	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:39448824C>T	ENST00000257408.4	+	4	2575	c.2478C>T	c.(2476-2478)ttC>ttT	p.F826F		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	826	Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						TCAACCACTTCACCACTAGGT	0.657000													21	90					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152325730	152325730	+	Nonsense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152325730G>C	ENST00000388718.5	-	3	4604	c.4532C>G	c.(4531-4533)tCa>tGa	p.S1511*	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1511							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGAGCCCCCTGAGTGCACTTC	0.493000													88	364					0	0	1	0	0
FSCN2	25794	broad.mit.edu	37	17	79503966	79503966	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:79503966G>C	ENST00000417245.2	+	5	1475	c.1339G>C	c.(1339-1341)Gag>Cag	p.E447Q	FSCN2_ENST00000334850.7_Missense_Mutation_p.E471Q	NM_001077182.2|NM_012418.3	NP_001070650.1|NP_036550.1	O14926	FSCN2_HUMAN	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	447					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging			endometrium(1)|lung(1)|prostate(1)|urinary_tract(1)	4	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CGAACGCGCCGAGGACTTCGT	0.761000													6	14					0	0	1	0	0
CUL3	8452	broad.mit.edu	37	2	225371615	225371615	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:225371615G>T	ENST00000264414.4	-	7	1327	c.989C>A	c.(988-990)tCt>tAt	p.S330Y	CUL3_ENST00000344951.4_Missense_Mutation_p.S264Y|CUL3_ENST00000409096.1_Missense_Mutation_p.S306Y|CUL3_ENST00000409777.1_Missense_Mutation_p.S306Y	NM_003590.4	NP_003581.1	Q13618	CUL3_HUMAN	cullin 3	330					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TCCTTCTTCAGAAACAAGAGC	0.378000													8	45					0.00307968	0.00312888	1	1	0
NINL	22981	broad.mit.edu	37	20	25456923	25456923	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:25456923C>T	ENST00000278886.6	-	17	3077	c.3004G>A	c.(3004-3006)Gag>Aag	p.E1002K	NINL_ENST00000422516.1_Intron	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	1002					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						AGGGCGCCCTCGGCCCGGGCC	0.677000													12	94					0	0	1	0	0
APEX2	27301	broad.mit.edu	37	X	55033806	55033806	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:55033806C>T	ENST00000374987.3	+	6	1561	c.1495C>T	c.(1495-1497)Cgg>Tgg	p.R499W		NM_014481.2	NP_055296.2	Q9UBZ4	APEX2_HUMAN	APEX nuclease (apurinic/apyrimidinic endonuclease) 2	499					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)|endometrium(8)|large_intestine(4)|lung(6)|prostate(1)|urinary_tract(1)	21						TGCCAGGCCCCGGGGTCCTCC	0.642000								Other BER factors					4	13					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43898837	43898837	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:43898837G>A	ENST00000562955.1	+	39	5609	c.5609G>A	c.(5608-5610)cGt>cAt	p.R1870H	SZT2_ENST00000372442.1_Missense_Mutation_p.R1028H	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1927						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CTGCAGGACCGTGTGGAAGTG	0.607000													13	122					0	0	1	0	0
SGTA	6449	broad.mit.edu	37	19	2762518	2762518	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:2762518C>T	ENST00000221566.2	-	7	783	c.622G>A	c.(622-624)Gag>Aag	p.E208K		NM_003021.3	NP_003012.1	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	208					interspecies interaction between organisms	cytoplasm	protein binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGGGGCCTCCCGCAGCTTC	0.647000													12	111					0	0	1	0	0
KIFC2	90990	broad.mit.edu	37	8	145693121	145693121	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:145693121G>C	ENST00000301332.2	+	6	1017	c.640G>C	c.(640-642)Gaa>Caa	p.E214Q	KIFC2_ENST00000301331.5_5'UTR	NM_145754.2	NP_665697.1	Q96AC6	KIFC2_HUMAN	kinesin family member C2	214	Gln-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(3)|prostate(3)|skin(2)|urinary_tract(1)	19	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GCAGCAGCTGGAACAGCAGGA	0.647000											OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	97					0	0	1	0	0
TYRO3	7301	broad.mit.edu	37	15	41870164	41870164	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:41870164A>G	ENST00000263798.3	+	19	2587	c.2363A>G	c.(2362-2364)aAc>aGc	p.N788S	TYRO3_ENST00000559066.1_Missense_Mutation_p.N743S	NM_006293.3	NP_006284.2	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase	788	Protein kinase.					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(26)|ovary(3)|prostate(1)	43		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GAACTGGAGAACATCTTGGGC	0.572000													4	109					0	0	1	0	0
PLIN2	123	broad.mit.edu	37	9	19119735	19119735	+	Silent	SNP	A	A	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:19119735A>T	ENST00000276914.2	-	6	869	c.690T>A	c.(688-690)cgT>cgA	p.R230R	PLIN2_ENST00000411567.1_Intron	NM_001122.3	NP_001113.2	Q99541	PLIN2_HUMAN	perilipin 2	230					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	19						GCTGGTAGGCACGGGAGTGAA	0.433000													10	140					0	0	1	0	0
ZZZ3	26009	broad.mit.edu	37	1	78098534	78098536	+	In_Frame_Del	DEL	AGT	AGT	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:78098534_78098536delAGT	ENST00000370801.3	-	5	979_981	c.504_506delACT	c.(502-507)atactg>atg	p.168_169IL>M	ZZZ3_ENST00000370798.1_Intron|ZZZ3_ENST00000476275.1_5'UTR	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						ACAATCATCCAGTATAAGACATC	0.409													14	223	---	---	---	---					
TXNIP	10628	broad.mit.edu	37	1	145440508	145440509	+	Frame_Shift_Ins	INS	-	-	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:145440508_145440509insT	ENST00000369317.4	+	5	1148_1149	c.814_815insT	c.(814-816)gttfs	p.V272fs	TXNIP_ENST00000475171.1_Intron	NM_006472.3	NP_006463.3	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	272					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	21	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CATCCTTCGAGTTGAATATTCC	0.485													20	184	---	---	---	---					
GPR75	10936	broad.mit.edu	37	2	54080472	54080472	+	Frame_Shift_Del	DEL	G	G	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:54080472delG	ENST00000394705.2	-	2	1692	c.1422delC	c.(1420-1422)cccfs	p.P474fs	ASB3_ENST00000406625.2_Intron|GPR75-ASB3_ENST00000352846.3_Intron|ASB3_ENST00000498475.2_Intron	NM_006794.3	NP_006785.1	O95800	GPR75_HUMAN	G protein-coupled receptor 75	474						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GAGTGTTGATGGGGGTCGAGC	0.493													19	312	---	---	---	---					
GRIP2	80852	broad.mit.edu	37	3	14555758	14555759	+	RNA	INS	-	-	AGTT	rs10656368	by1000genomes	TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:14555758_14555759insAGTT	ENST00000273083.3	-	0	1558							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CAGTTTCTCTCAGAGAGTGGCA	0.579													4	4	---	---	---	---					
DBR1	51163	broad.mit.edu	37	3	137880741	137880743	+	In_Frame_Del	DEL	TCG	TCG	-	rs2622736	byFrequency	TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:137880741_137880743delTCG	ENST00000260803.4	-	8	1776_1778	c.1623_1625delCGA	c.(1621-1626)gacgat>gat	p.541_542DD>D	DBR1_ENST00000505015.2_In_Frame_Del_p.307_308DD>D	NM_016216.3	NP_057300.2	Q9UK59	DBR1_HUMAN	debranching RNA lariats 1	541						nucleus	metal ion binding|RNA lariat debranching enzyme activity			NS(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	15						TTAAGCTGCATCGTCATCATCAT	0.394													7	110	---	---	---	---					
RP11-368M16.3	0	broad.mit.edu	37	7	57698565	57698566	+	RNA	INS	-	-	TGGG			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:57698565_57698566insTGGG	ENST00000605139.1	-	0	416																											CACAGGAGACCTGGGCTGCAGG	0.584													2	4	---	---	---	---					
LOC101928451	101928451	broad.mit.edu	37	7	128249538	128249539	+	RNA	INS	-	-	AC			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:128249538_128249539insAC	ENST00000605862.1	+	0	665																											TTTGTCTCTGTAGTCCAACCTC	0.356													12	40	---	---	---	---					
TRBV6-5	28602	broad.mit.edu	37	7	142180819	142180821	+	RNA	DEL	AGG	AGG	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:142180819_142180821delAGG	ENST00000390368.2	-	0	115																											CCTGCAGAGAAGGAGAACAAAGC	0.557													9	156	---	---	---	---					
TMEM19	55266	broad.mit.edu	37	12	72094757	72094757	+	Frame_Shift_Del	DEL	T	T	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:72094757delT	ENST00000266673.5	+	6	1587	c.993delT	c.(991-993)ggtfs	p.G331fs		NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	331						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGCTTGGGGTTTTTGGCCCA	0.433													7	464	---	---	---	---					
HCAR1	27198	broad.mit.edu	37	12	123214852	123214853	+	Frame_Shift_Ins	INS	-	-	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:123214852_123214853insC	ENST00000432564.1	-	1	276_277	c.34_35insG	c.(34-36)gacfs	p.D12fs	HCAR1_ENST00000436083.2_Frame_Shift_Ins_p.D12fs|HCAR1_ENST00000356987.2_Frame_Shift_Ins_p.D12fs	NM_032554.3	NP_115943.1	Q9BXC0	HCAR1_HUMAN	hydroxycarboxylic acid receptor 1	12					response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)	10						GGAGATGGTGTCCCCCTCGATG	0.619													8	53	---	---	---	---					
CHD2	1106	broad.mit.edu	37	15	93545433	93545434	+	Frame_Shift_Ins	INS	-	-	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:93545433_93545434insA	ENST00000394196.4	+	33	5232_5233	c.4164_4165insA	c.(4165-4167)aaafs	p.K1389fs	CHD2_ENST00000557381.1_Frame_Shift_Ins_p.K1389fs	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1389					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AAAGTCCAATgaaaaaaaaaca	0.337													7	146	---	---	---	---					
TBC1D24	57465	broad.mit.edu	37	16	2546657	2546657	+	Frame_Shift_Del	DEL	G	G	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:2546657delG	ENST00000567020.1	+	2	648	c.508delG	c.(508-510)gacfs	p.D170fs	TBC1D24_ENST00000434757.2_Frame_Shift_Del_p.D170fs|RP11-20I23.1_ENST00000564543.1_Frame_Shift_Del_p.D170fs|TBC1D24_ENST00000293970.5_Frame_Shift_Del_p.D170fs	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	170	Rab-GAP TBC.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						GAGGCTGATCGACCAGAGCTT	0.632													7	64	---	---	---	---					
MNT	4335	broad.mit.edu	37	17	2290220	2290220	+	Frame_Shift_Del	DEL	G	G	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:2290220delG	ENST00000174618.4	-	6	2129	c.1724delC	c.(1723-1725)ccafs	p.P575fs		NM_020310.2	NP_064706.1	Q99583	MNT_HUMAN	MAX network transcriptional repressor	575					multicellular organismal development|negative regulation of cell proliferation|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			endometrium(4)|large_intestine(5)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	12				Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)		TGTGCTGACTGGGAAGGAGGG	0.667													2	4	---	---	---	---					
ARHGEF6	9459	broad.mit.edu	37	X	135814312	135814312	+	Frame_Shift_Del	DEL	T	T	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:135814312delT	ENST00000250617.6	-	6	1886	c.681delA	c.(679-681)aaafs	p.K227fs	ARHGEF6_ENST00000370620.1_Frame_Shift_Del_p.K73fs|ARHGEF6_ENST00000535227.1_Frame_Shift_Del_p.K100fs|ARHGEF6_ENST00000370622.1_Frame_Shift_Del_p.K73fs	NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	227					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					CTTTGACGGCTTTTGGGGAGA	0.328													2	4	---	---	---	---					
