Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CCDC77	84318	broad.mit.edu	37	12	550091	550091	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr12:550091G>T	ENST00000239830.4	+	12	1428	c.1249G>T	c.(1249-1251)Gta>Tta	p.V417L	CCDC77_ENST00000540180.1_Missense_Mutation_p.V385L|CCDC77_ENST00000422000.1_Missense_Mutation_p.V385L|CCDC77_ENST00000412006.2_Missense_Mutation_p.V385L	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	417						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			TATCCTGGAAGTAGAAGGCTT	0.433000													28	42					1.77063e-15	2.0025e-15	1	1	0
GNAZ	2781	broad.mit.edu	37	22	23438530	23438530	+	Silent	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr22:23438530C>T	ENST00000248996.4	+	2	1314	c.648C>T	c.(646-648)ttC>ttT	p.F216F	RTDR1_ENST00000216036.4_Intron	NM_002073.2	NP_002064.1	P19086	GNAZ_HUMAN	guanine nucleotide binding protein (G protein), alpha z polypeptide	216						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(5)|urinary_tract(1)	19	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		TCCACTGCTTCGAGGGCGTCA	0.562000													78	104					0	0	1	0	0
EIF6	3692	broad.mit.edu	37	20	33872044	33872044	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr20:33872044G>T	ENST00000374450.3	-	3	392	c.128C>A	c.(127-129)tCc>tAc	p.S43Y	EIF6_ENST00000462894.1_5'UTR|EIF6_ENST00000374443.3_Missense_Mutation_p.P83T|EIF6_ENST00000374436.3_Missense_Mutation_p.S43Y	NM_002212.3	NP_002203.1	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6	43					mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GATGGTATCGGAGAGCTCGCC	0.677000													28	41					3.86903e-22	4.48241e-22	1	1	0
OR51B5	282763	broad.mit.edu	37	11	5363992	5363992	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr11:5363992C>A	ENST00000300773.2	-	1	817	c.763G>T	c.(763-765)Gga>Tga	p.G255*	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAGACAATCCAATCACTGTG	0.448000													18	36					2.37509e-13	2.59349e-13	1	1	0
IFNA2	3440	broad.mit.edu	37	9	21384772	21384772	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr9:21384772C>T	ENST00000380206.2	-	1	624	c.557G>A	c.(556-558)aGt>aAt	p.S186N		NM_000605.3	NP_000596.2	P01563	IFNA2_HUMAN	interferon, alpha 2	186					blood coagulation|cell-cell signaling|induction of apoptosis|inflammatory response|negative regulation of interleukin-13 secretion|negative regulation of interleukin-5 secretion|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of transcription, DNA-dependent|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(2)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)	13				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)	Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	TCATTCCTTACTTCTTAAACT	0.378000													45	57					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84103573	84103573	+	Missense_Mutation	SNP	G	G	A	rs140160203		TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr16:84103573G>A	ENST00000343411.3	-	14	2348	c.1853C>T	c.(1852-1854)cCg>cTg	p.P618L		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	618					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CTTGCTTCGCGGGGGAGTAGG	0.428000													100	9					0	0	1	0	0
EIF5B	9669	broad.mit.edu	37	2	99995514	99995514	+	Silent	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr2:99995514C>T	ENST00000289371.6	+	11	2077	c.1875C>T	c.(1873-1875)aaC>aaT	p.N625N		NM_015904.3	NP_056988.3	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B						regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AAAATGTAAACACCGAAAAGC	0.299000													6	15					0	0	1	0	0
KBTBD3	143879	broad.mit.edu	37	11	105924764	105924764	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr11:105924764C>T	ENST00000526793.1	-	3	811	c.652G>A	c.(652-654)Gtt>Att	p.V218I	KBTBD3_ENST00000531837.1_Missense_Mutation_p.V218I|KBTBD3_ENST00000534815.1_Missense_Mutation_p.V139I	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	214	BACK.									NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		CTAAGGACAACTTTCAGTACC	0.333000													18	51					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47365610	47365610	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr18:47365610C>A	ENST00000285039.7	-	36	5055	c.4756G>T	c.(4756-4758)Gac>Tac	p.D1586Y	MYO5B_ENST00000324581.6_Missense_Mutation_p.D701Y|MYO5B_ENST00000592688.1_Missense_Mutation_p.D156Y|SCARNA17_ENST00000589499.1_RNA	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1586	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TCGGTGAGGTCAAAATTCTTA	0.493000													27	45					2.48779e-11	2.68569e-11	1	1	0
TNFRSF10A	8797	broad.mit.edu	37	8	23082527	23082527	+	Silent	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr8:23082527C>T	ENST00000221132.3	-	1	112	c.48G>A	c.(46-48)gtG>gtA	p.V16V	RP11-1149O23.3_ENST00000517774.1_RNA	NM_003844.3	NP_003835.3	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily, member 10a	16					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			NS(2)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|skin(1)	16		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		GATTCGGAGTCACTGCCAGGA	0.612000													13	1					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87489308	87489308	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr10:87489308G>A	ENST00000327946.7	-	9	1382	c.1297C>T	c.(1297-1299)Cgc>Tgc	p.R433C	GRID1_ENST00000536331.1_Missense_Mutation_p.R4C	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	433						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	CCTTGGAGGCGGCTGCCCATG	0.517000										Multiple Myeloma(13;0.14)			21	46					0	0	1	0	0
EPHX3	79852	broad.mit.edu	37	19	15338452	15338452	+	Silent	SNP	C	C	T	rs143850888	byFrequency	TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr19:15338452C>T	ENST00000221730.3	-	7	1099	c.879G>A	c.(877-879)caG>caA	p.Q293Q	EPHX3_ENST00000435261.1_Silent_p.Q293Q|EPHX3_ENST00000602233.1_Silent_p.Q293Q	NM_024794.2	NP_079070.1	Q9H6B9	EPHX3_HUMAN	epoxide hydrolase 3	293						extracellular region	hydrolase activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						TGGTCAGCTCCTGGGGTTCCA	0.632000													12	18					0	0	1	0	0
SEMG2	6407	broad.mit.edu	37	20	43850875	43850875	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr20:43850875T>C	ENST00000372769.3	+	2	692	c.602T>C	c.(601-603)cTa>cCa	p.L201P		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	201	Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				ACTGAAGAACTAGTAGTTAAC	0.383000													26	25					0	0	1	0	0
SLC25A12	8604	broad.mit.edu	37	2	172725255	172725255	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr2:172725255C>G	ENST00000422440.2	-	3	182	c.145G>C	c.(145-147)Gat>Cat	p.D49H	SLC25A12_ENST00000472748.1_5'UTR|SLC25A12_ENST00000392592.4_5'UTR	NM_003705.4	NP_003696.2	O75746	CMC1_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 12	49					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|upper_aerodigestive_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	CTATTTGGATCATTATACAGT	0.383000													24	34					0	0	1	0	0
RXRA	6256	broad.mit.edu	37	9	137309085	137309085	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr9:137309085C>T	ENST00000540193.1	+	4	1324	c.401C>T	c.(400-402)cCg>cTg	p.P134L	RXRA_ENST00000356384.4_3'UTR|RXRA_ENST00000481739.1_Missense_Mutation_p.P231L			P19793	RXRA_HUMAN	retinoid X receptor, alpha	231	Modulating (By similarity).				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding	p.P231L(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GAGGACATGCCGGTGGAGAGG	0.652000													12	31					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6457364	6457364	+	Missense_Mutation	SNP	G	G	A	rs137852635		TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr12:6457364G>A	ENST00000358945.3	-	13	2191	c.1751C>T	c.(1750-1752)tCg>tTg	p.S584L	SCNN1A_ENST00000540037.1_Missense_Mutation_p.S262L|SCNN1A_ENST00000228916.2_Missense_Mutation_p.S562L|SCNN1A_ENST00000396966.2_3'UTR|SCNN1A_ENST00000360168.3_Missense_Mutation_p.S621L|SCNN1A_ENST00000543768.1_Missense_Mutation_p.S585L			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	562					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	AGACAACACCGAGGAGCCGAA	0.572000													15	22					0	0	1	0	0
ZNF783	100289678	broad.mit.edu	37	7	148963916	148963916	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr7:148963916G>A	ENST00000434415.1	+	3	590	c.427G>A	c.(427-429)Gtg>Atg	p.V143M		NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	143					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			CCAGGTGCCCGTGACCTTCGA	0.607000													44	70					0	0	1	0	0
PTGER2	5732	broad.mit.edu	37	14	52781415	52781415	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr14:52781415G>A	ENST00000245457.5	+	1	303	c.149G>A	c.(148-150)tGg>tAg	p.W50*	PTGER2_ENST00000557436.1_Intron	NM_000956.3	NP_000947.2	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	50						integral to plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	GCGCGCCGCTGGCGGGGGGAC	0.697000													5	9					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38103714	38103714	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr3:38103714T>A	ENST00000308059.6	+	4	749	c.728T>A	c.(727-729)gTc>gAc	p.V243D	DLEC1_ENST00000452631.2_Missense_Mutation_p.V243D|DLEC1_ENST00000346219.3_Missense_Mutation_p.V243D			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	243					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		AAGCGTTCCGTCCAGAAGAAA	0.463000													26	24					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102292839	102292839	+	RNA	SNP	C	C	A	rs62026971		TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr15:102292839C>A	ENST00000561463.1	+	0	885																											CTCGTGGAGGCGTCGGCAGAG	0.597000													3	15					1	1	1	1	0
SLC2A3	6515	broad.mit.edu	37	12	8086455	8086455	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr12:8086455C>T	ENST00000075120.7	-	2	299	c.59G>A	c.(58-60)gGc>gAc	p.G20D		NM_006931.2	NP_008862.1	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 3	20					carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(14)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				Kidney(36;0.0866)		TTGGAAAGAGCCGATTGTAGC	0.448000											OREG0021656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	34					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502714	91502714	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr12:91502714C>T	ENST00000266718.4	-	2	497	c.43G>A	c.(43-45)Ggt>Agt	p.G15S	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	15					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						CCACTGGTACCACCAATCAAT	0.363000													11	24					0	0	1	0	0
ADARB2	105	broad.mit.edu	37	10	1405908	1405908	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr10:1405908A>G	ENST00000381312.1	-	3	717	c.392T>C	c.(391-393)gTg>gCg	p.V131A		NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	131	DRBM 1.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GTGCAGCTGCACCAGCGCGTT	0.677000													9	13					0	0	1	0	0
C10orf90	118611	broad.mit.edu	37	10	128193466	128193466	+	Silent	SNP	C	C	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr10:128193466C>A	ENST00000284694.7	-	3	423	c.303G>T	c.(301-303)gcG>gcT	p.A101A	C10orf90_ENST00000454341.1_Silent_p.A101A|C10orf90_ENST00000368674.1_5'UTR|C10orf90_ENST00000544758.1_Silent_p.A198A|C10orf90_ENST00000392694.1_Silent_p.A54A|C10orf90_ENST00000356858.3_Silent_p.A54A	NM_001004298.2	NP_001004298.2	Q96M02	CJ090_HUMAN	chromosome 10 open reading frame 90	101										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(19)|liver(1)|lung(29)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	65		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		CCGGAAGTAACGCAAATGCTC	0.602000											OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	46					5.44703e-19	6.23455e-19	1	1	0
KIAA2026	158358	broad.mit.edu	37	9	6007677	6007677	+	Silent	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr9:6007677C>T	ENST00000399933.3	-	1	110	c.111G>A	c.(109-111)caG>caA	p.Q37Q	KIAA2026_ENST00000381461.2_Silent_p.Q37Q	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	37										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		GCCCTGAGGTCTGGGCCGCCG	0.716000													6	11					0	0	1	0	0
NDUFA10	4705	broad.mit.edu	37	2	240946758	240946758	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr2:240946758G>T	ENST00000252711.2	-	7	879	c.779C>A	c.(778-780)gCa>gAa	p.A260E	NDUFA10_ENST00000404554.1_Missense_Mutation_p.A260E|NDUFA10_ENST00000307300.4_Missense_Mutation_p.A290E	NM_004544.3	NP_004535.1	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	260					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)	16		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	AGCTTCCCTTGCAGAATATTG	0.308000													5	13					0.000602214	0.000615165	1	1	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													5	150					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41877360	41877360	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr3:41877360G>A	ENST00000301831.4	-	18	2222	c.1760C>T	c.(1759-1761)aCc>aTc	p.T587I		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	587							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TCTCACCTGGGTGGCTACAAG	0.378000													50	59					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55562761	55562761	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr1:55562761G>A	ENST00000294383.6	-	49	5799	c.5800C>T	c.(5800-5802)Cga>Tga	p.R1934*	USP24_ENST00000407756.1_Nonsense_Mutation_p.R1774*	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1934					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						TCCACACTTCGCCCATTTTCC	0.488000													18	30					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112182795	112182795	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr9:112182795C>A	ENST00000412145.1	-	9	3382	c.829G>T	c.(829-831)Gaa>Taa	p.E277*	PTPN3_ENST00000374541.2_Nonsense_Mutation_p.E408*|PTPN3_ENST00000262539.3_Nonsense_Mutation_p.E254*|PTPN3_ENST00000446349.1_Nonsense_Mutation_p.E232*	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	408	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						TCTTCCGTTTCCGTGATGTAG	0.507000													22	15					2.39556e-15	2.6774e-15	1	1	0
ABCA9	10350	broad.mit.edu	37	17	67008197	67008197	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr17:67008197G>A	ENST00000340001.4	-	23	3278	c.3067C>T	c.(3067-3069)Cga>Tga	p.R1023*	ABCA9_ENST00000453985.2_Nonsense_Mutation_p.R1023*|ABCA9-AS1_ENST00000458677.1_RNA|ABCA9_ENST00000370732.2_Nonsense_Mutation_p.R1023*	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	1023					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					GTGTTACTTCGGTACCCATAC	0.418000													16	65					0	0	1	0	0
SEC16A	9919	broad.mit.edu	37	9	139371086	139371086	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr9:139371086G>A	ENST00000313050.7	-	1	1055	c.982C>T	c.(982-984)Cgg>Tgg	p.R328W	SEC16A_ENST00000431893.2_Missense_Mutation_p.R150W|SEC16A_ENST00000290037.6_Missense_Mutation_p.R150W|SEC16A_ENST00000371706.3_Missense_Mutation_p.R150W	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	150					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GAGGCGGGCCGGTGCTCATTC	0.592000													15	17					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20388887	20388887	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr14:20388887G>A	ENST00000315915.4	+	1	147	c.122G>A	c.(121-123)gGa>gAa	p.G41E		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATTGTGCTGGGAAATCTTCTC	0.413000													45	157					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153026544	153026544	+	Missense_Mutation	SNP	A	A	C			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr5:153026544A>C	ENST00000285900.5	+	3	620	c.277A>C	c.(277-279)Act>Cct	p.T93P	GRIA1_ENST00000448073.4_Missense_Mutation_p.T103P|GRIA1_ENST00000518142.1_Intron|GRIA1_ENST00000518783.1_Missense_Mutation_p.T103P|GRIA1_ENST00000518862.1_3'UTR|GRIA1_ENST00000521843.2_Missense_Mutation_p.T24P|GRIA1_ENST00000340592.5_Missense_Mutation_p.T93P	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	93					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGAACGTAGGACTGTCAACAT	0.463000													41	45					0	0	1	0	0
RBP4	5950	broad.mit.edu	37	10	95353761	95353761	+	Silent	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr10:95353761G>A	ENST00000371467.1	-	5	706	c.387C>T	c.(385-387)taC>taT	p.Y129Y	RBP4_ENST00000371464.3_Silent_p.Y129Y|FFAR4_ENST00000604414.1_Intron|RBP4_ENST00000371469.2_Silent_p.Y127Y			P02753	RET4_HUMAN	retinol binding protein 4, plasma	129					cardiac muscle tissue development|embryonic organ morphogenesis|embryonic retina morphogenesis in camera-type eye|embryonic skeletal system development|female genitalia morphogenesis|gluconeogenesis|glucose homeostasis|heart trabecula formation|lung development|maintenance of gastrointestinal epithelium|negative regulation of cardiac muscle cell proliferation|positive regulation of immunoglobulin secretion|positive regulation of insulin secretion|response to retinoic acid|retinol metabolic process|urinary bladder development|uterus development|vagina development	extracellular space	protein binding|retinal binding|retinol binding			large_intestine(1)|lung(3)|skin(1)	5		Colorectal(252;0.122)			Vitamin A(DB00162)	CATACGTGTCGTAGTCTGTGT	0.572000													18	54					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32975425	32975425	+	Silent	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr12:32975425G>A	ENST00000340811.4	-	8	1923	c.1815C>T	c.(1813-1815)ggC>ggT	p.G605G	PKP2_ENST00000070846.6_Silent_p.G649G	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	649					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGCTTCGACTGCCAAAACATC	0.393000													4	57					0	0	1	0	0
CA11	770	broad.mit.edu	37	19	49142241	49142241	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr19:49142241G>A	ENST00000084798.4	-	8	1544	c.865C>T	c.(865-867)Cgg>Tgg	p.R289W	SEC1P_ENST00000430145.2_RNA	NM_001217.3	NP_001208.2	O75493	CAH11_HUMAN	carbonic anhydrase XI	289						extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)	14		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000103)|all cancers(93;0.000119)|GBM - Glioblastoma multiforme(486;0.00634)|Epithelial(262;0.016)		TGCAGGGGCCGGCTGTTACCG	0.647000													5	4					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16492112	16492112	+	Silent	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr20:16492112G>A	ENST00000354981.2	-	6	664	c.507C>T	c.(505-507)acC>acT	p.T169T	KIF16B_ENST00000355755.3_Silent_p.T169T|KIF16B_ENST00000408042.1_Silent_p.T169T|KIF16B_ENST00000378003.2_5'UTR	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	169	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						TCAAATTGAAGGTTTTAGATG	0.328000													41	47					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109691914	109691914	+	Silent	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr9:109691914G>A	ENST00000277225.5	+	3	6010	c.5721G>A	c.(5719-5721)ctG>ctA	p.L1907L	ZNF462_ENST00000457913.1_Silent_p.L1907L|ZNF462_ENST00000441147.2_Silent_p.L752L			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1907					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CAGCCGAGCTGACCTCACACT	0.498000													14	16					0	0	1	0	0
TEX10	54881	broad.mit.edu	37	9	103111575	103111575	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr9:103111575T>C	ENST00000374902.4	-	2	247	c.71A>G	c.(70-72)aAg>aGg	p.K24R	TEX10_ENST00000535814.1_Missense_Mutation_p.K27R|TEX10_ENST00000537512.1_Intron	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	24						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		ATTTTGTAACTTGGGCTTCTT	0.308000													3	34					0	0	1	0	0
OR1E1	8387	broad.mit.edu	37	17	3301275	3301275	+	Missense_Mutation	SNP	G	G	C	rs1735010		TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr17:3301275G>C	ENST00000322608.2	-	1	429	c.430C>G	c.(430-432)Ctg>Gtg	p.L144V		NM_003553.2	NP_003544.2	P30953	OR1E1_HUMAN	olfactory receptor, family 1, subfamily E, member 1	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(2)|lung(5)	10						AGCGCCACCAGGGCGAGACAG	0.567000											OREG0007321	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=OR1E1|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	5	26					0	0	1	0	0
AGMO	392636	broad.mit.edu	37	7	15470660	15470660	+	Silent	SNP	T	T	C			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr7:15470660T>C	ENST00000342526.3	-	4	652	c.483A>G	c.(481-483)agA>agG	p.R161R		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	161					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						GGACAGACTGTCTCAGTGCTG	0.358000													28	30					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73649903	73649903	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr13:73649903A>G	ENST00000377687.4	+	4	1789	c.1253A>G	c.(1252-1254)gAt>gGt	p.D418G	KLF5_ENST00000539231.1_Missense_Mutation_p.D327G	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	418					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		GCGCGATCGGATGAGCTGACC	0.597000													20	37					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1552529	1552529	+	Silent	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr20:1552529G>A	ENST00000381605.4	-	3	652	c.588C>T	c.(586-588)aaC>aaT	p.N196N	RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000262929.5_Intron|SIRPB1_ENST00000381603.3_Intron	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	196	Ig-like C1-type 1.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.N196N(1)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CGGGGTCCACGTTGGTCTGGA	0.552000													36	49					0	0	1	0	0
ZNF275	10838	broad.mit.edu	37	X	152612855	152612855	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chrX:152612855G>A	ENST00000421401.3	+	4	889	c.712G>A	c.(712-714)Gcc>Acc	p.A238T	ZNF275_ENST00000370251.3_Missense_Mutation_p.A238T|ZNF275_ENST00000440091.1_Missense_Mutation_p.A268T|ZNF275_ENST00000370249.2_Missense_Mutation_p.A185T			A6NFS0	A6NFS0_HUMAN	zinc finger protein 275	238						intracellular	nucleic acid binding|zinc ion binding			endometrium(5)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AAAGCCTTTCGCCTGCAAGGC	0.577000													44	5					0	0	1	0	0
MSS51	118490	broad.mit.edu	37	10	75185672	75185672	+	Silent	SNP	T	T	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr10:75185672T>A	ENST00000299432.2	-	5	1031	c.966A>T	c.(964-966)acA>acT	p.T322T	MSS51_ENST00000372912.1_Silent_p.T322T	NM_001024593.1	NP_001019764.1	Q4VC12	ZMY17_HUMAN	MSS51 mitochondrial translational activator	322							zinc ion binding										TAAGCTGAATTGTGCCAGGTT	0.552000													16	34					0	0	1	0	0
AP3B1	8546	broad.mit.edu	37	5	77298758	77298758	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr5:77298758G>A	ENST00000255194.6	-	27	3428	c.3253C>T	c.(3253-3255)Cgg>Tgg	p.R1085W	AP3B1_ENST00000519295.1_Missense_Mutation_p.R1036W	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	1085					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TTCAGTTCCCGCAGCAGAACA	0.493000									Hermansky-Pudlak syndrome				31	39					0	0	1	0	0
GPAA1	8733	broad.mit.edu	37	8	145138146	145138146	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr8:145138146C>T	ENST00000355091.4	+	2	315	c.194C>T	c.(193-195)gCg>gTg	p.A65V	GPAA1_ENST00000527144.1_3'UTR|GPAA1_ENST00000361036.6_Intron	NM_003801.3	NP_003792.1	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment 1	65					attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(2)	19	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GAGCAGTTTGCGGGCGGAGAC	0.672000													4	86					0	0	1	0	0
PRLHR	2834	broad.mit.edu	37	10	120353838	120353838	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr10:120353838C>T	ENST00000239032.2	-	2	1057	c.919G>A	c.(919-921)Gcc>Acc	p.A307T	PRLHR_ENST00000369169.1_Missense_Mutation_p.A307T	NM_004248.2	NP_004239	P49683	PRLHR_HUMAN	prolactin releasing hormone receptor	307					female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity	p.A307P(1)		large_intestine(2)|lung(8)|ovary(1)|skin(1)	12		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GGGTCGATGGCGTGGGGGTCG	0.647000													21	36					0	0	1	0	0
CTNNB1	1499	broad.mit.edu	37	3	41266137	41266137	+	Missense_Mutation	SNP	C	C	T	rs121913409		TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr3:41266137C>T	ENST00000349496.5	+	3	414	c.134C>T	c.(133-135)tCt>tTt	p.S45F	CTNNB1_ENST00000453024.1_Missense_Mutation_p.S38F|CTNNB1_ENST00000396185.3_Missense_Mutation_p.S45F|CTNNB1_ENST00000396183.3_Missense_Mutation_p.S45F|CTNNB1_ENST00000405570.1_Missense_Mutation_p.S45F	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	45			Missing (in colorectal cancer).|S -> F (in hepatocellular carcinoma).|S -> P (in hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.S45F(384)|p.S45del(53)|p.A5_A80del(53)|p.S45C(19)|p.S45Y(17)|p.A5_Q143del(7)|p.A5_A80>D(7)|p.Q28_H134del(5)|p.?(4)|p.W25_I140del(3)|p.T3_A126del(2)|p.S45_S47>C(2)|p.D32_S47del(2)|p.P44_S45del(2)|p.M5_N141>D(2)|p.L10_N141del(2)|p.A5_Y142>D(2)|p.A5_Q143>E(1)|p.S37_G48>C(1)|p.A13_R151del(1)|p.H36_E53>L(1)|p.M14_S45del(1)|p.S45_G48del(1)|p.Q28_Q61del(1)|p.T41_N51del(1)|p.M1_A87del(1)|p.S45_L46del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.P44_N51del(1)|p.I35_K170del(1)|p.Y30_A97del(1)|p.T42_G48del(1)|p.S45_D58del(1)|p.V22_T102del(1)|p.A20_A80del(1)|p.V22_S71>A(1)|p.S45fs*2(1)|p.T40_L46del(1)|p.A5_T59del(1)|p.M1_V173del(1)|p.E15_I140>V(1)|p.H24_M131del(1)|p.S45E(1)|p.M8_A80del(1)|p.A5_E54del(1)|p.A21_A80del(1)|p.P16_K133del(1)|p.V22_Y64del(1)|p.A20_S111del(1)|p.T42_K49>Q(1)|p.Y30_A80del(1)	CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	ACAGCTCCTTCTCTGAGTGGT	0.498000	S45F(HCC15_LUNG)|S45F(LS180_LARGE_INTESTINE)	15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				12	16					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70065826	70065826	+	RNA	SNP	T	T	C	rs3169319	by1000genomes	TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr16:70065826T>C	ENST00000531894.1	-	0	796					NR_003610.1													p.M209V(4)									GATCCAAACATAGTGTTACAG	0.453000													4	56					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	101023036	101023036	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr3:101023036C>T	ENST00000193391.7	-	3	642	c.455G>A	c.(454-456)gGc>gAc	p.G152D		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	152					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						AAAATTTGTGCCCATTTCAAA	0.408000													4	79					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112182796	112182796	+	Silent	SNP	C	C	A	rs142732873	byFrequency	TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr9:112182796C>A	ENST00000412145.1	-	9	3381	c.828G>T	c.(826-828)acG>acT	p.T276T	PTPN3_ENST00000374541.2_Silent_p.T407T|PTPN3_ENST00000262539.3_Silent_p.T253T|PTPN3_ENST00000446349.1_Silent_p.T231T	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	407	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						CTTCCGTTTCCGTGATGTAGG	0.507000													22	15					7.87624e-14	8.7005e-14	1	1	0
IKZF1	10320	broad.mit.edu	37	7	50468301	50468301	+	Silent	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr7:50468301G>A	ENST00000331340.3	+	8	1691	c.1536G>A	c.(1534-1536)ggG>ggA	p.G512G	IKZF1_ENST00000343574.5_Silent_p.G425G|IKZF1_ENST00000438033.1_Silent_p.G425G|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000349824.4_Silent_p.G369G|IKZF1_ENST00000439701.1_Silent_p.G470G|IKZF1_ENST00000346667.4_Silent_p.G282G|IKZF1_ENST00000359197.5_Silent_p.G470G|IKZF1_ENST00000357364.4_Silent_p.G425G	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	512					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				TAACGCGAGGGGAGCACCGCT	0.637000			"""D,T"""	BCL6	"""ALL, DLBCL"""								16	9					0	0	1	0	0
FAM86EP	348926	broad.mit.edu	37	4	3944146	3944146	+	RNA	SNP	A	A	G			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr4:3944146A>G	ENST00000313946.8	-	0	2185																											CTGATCCTGCAGGCAAGCTAA	0.537000													4	17					0	0	1	0	0
SHOX2	6474	broad.mit.edu	37	3	157823797	157823797	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr3:157823797G>T	ENST00000389589.4	-	1	152	c.17C>A	c.(16-18)gCg>gAg	p.A6E	SHOX2_ENST00000483851.2_Missense_Mutation_p.A6E|SHOX2_ENST00000441443.2_5'UTR|RSRC1_ENST00000480820.1_5'UTR|SHOX2_ENST00000425436.3_Missense_Mutation_p.A6E|SHOX2_ENST00000554685.1_5'UTR	NM_003030.4	NP_003021.3	O60902	SHOX2_HUMAN	short stature homeobox 2	6					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(10)|skin(3)|upper_aerodigestive_tract(1)	20			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			GGAGACGAACGCCGTAAGTTC	0.592000													14	19					6.72482e-11	7.17818e-11	1	1	0
PCBP1	5093	broad.mit.edu	37	2	70315530	70315530	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr2:70315530C>G	ENST00000303577.5	+	1	946	c.655C>G	c.(655-657)Cta>Gta	p.L219V	PCBP1-AS1_ENST00000452431.1_RNA|PCBP1-AS1_ENST00000596028.1_RNA	NM_006196.3	NP_006187.2	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	219					nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|skin(1)	12						GGGACCACCTCTAGATGCCTA	0.602000													7	11					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657782	197657782	+	Silent	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr2:197657782C>T	ENST00000263956.3	-	3	398	c.309G>A	c.(307-309)gaG>gaA	p.E103E	GTF3C3_ENST00000409364.3_Silent_p.E103E	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	103	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding	p.E103E(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						cctcctcctcctcttcttcct	0.468000													3	40					0	0	1	0	0
FAM20A	54757	broad.mit.edu	37	17	66535530	66535530	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr17:66535530G>A	ENST00000592554.1	-	10	2031	c.1309C>T	c.(1309-1311)Cga>Tga	p.R437*	PRKAR1A_ENST00000588188.2_Intron|FAM20A_ENST00000226094.5_5'UTR	NM_001243746.1|NM_017565.3	NP_001230675.1|NP_060035.2	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	437						extracellular region				cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|stomach(1)	9	Breast(10;1.64e-13)					TGGGAGTGTCGTCCGAACCTA	0.512000													12	65					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71780310	71780310	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr2:71780310T>C	ENST00000258104.3	+	20	2199	c.1922T>C	c.(1921-1923)gTc>gCc	p.V641A	DYSF_ENST00000413539.2_Missense_Mutation_p.V672A|DYSF_ENST00000409651.1_Missense_Mutation_p.V673A|DYSF_ENST00000429174.2_Missense_Mutation_p.V641A|DYSF_ENST00000410041.1_Missense_Mutation_p.V659A|DYSF_ENST00000409582.3_Missense_Mutation_p.V658A|DYSF_ENST00000409744.1_Missense_Mutation_p.V628A|DYSF_ENST00000410020.3_Missense_Mutation_p.V659A|DYSF_ENST00000409762.1_Missense_Mutation_p.V658A|DYSF_ENST00000409366.1_Missense_Mutation_p.V642A|DYSF_ENST00000394120.2_Missense_Mutation_p.V642A	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	641						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						AGCCGTGCAGTCTTTGACGGT	0.587000													14	17					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80404869	80404869	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr5:80404869T>C	ENST00000265080.4	+	13	1877	c.1810T>C	c.(1810-1812)Tcc>Ccc	p.S604P		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	604					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TGAAGAGAATTCCAAAGTCAC	0.333000													15	31					0	0	1	0	0
GJA5	2702	broad.mit.edu	37	1	147230326	147230326	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr1:147230326T>C	ENST00000271348.2	-	2	1182	c.1021A>G	c.(1021-1023)Aag>Gag	p.K341E	GJA5_ENST00000369237.1_Missense_Mutation_p.K341E|RP11-433J22.2_ENST00000428911.1_RNA	NM_005266.5	NP_005257.2	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	341					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			AGACGTCGCTTGTCACTATGA	0.547000													28	25					0	0	1	0	0
MIOS	54468	broad.mit.edu	37	7	7612385	7612385	+	Silent	SNP	T	T	C			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr7:7612385T>C	ENST00000340080.4	+	4	700	c.279T>C	c.(277-279)ggT>ggC	p.G93G	MIOS_ENST00000405785.1_Silent_p.G93G	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)	93										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CAAGCCTTGGTCAAGATCATA	0.398000													32	43					0	0	1	0	0
TLR8	51311	broad.mit.edu	37	X	12939151	12939151	+	Silent	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chrX:12939151G>A	ENST00000218032.6	+	2	2079	c.1992G>A	c.(1990-1992)gcG>gcA	p.A664A	TLR8_ENST00000311912.5_Silent_p.A682A	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	664					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						ATTTGCCAGCGAGTCTCACTG	0.383000													30	2					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000256078.4_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			25	29					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274415	39274415	+	Silent	SNP	C	C	T	rs425487	by1000genomes	TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr17:39274415C>T	ENST00000391413.2	-	1	191	c.153G>A	c.(151-153)agG>agA	p.R51R		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	51	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament		p.R51R(6)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGCACTGGGGCCTGCAGCAGC	0.667000													5	78					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111794202	111794202	+	Silent	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr3:111794202C>T	ENST00000452346.2	+	15	1821	c.1818C>T	c.(1816-1818)atC>atT	p.I606I	TMPRSS7_ENST00000419127.1_Silent_p.I480I			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	606	Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						TTCACCGCATCATCGGAGGCA	0.547000													4	85					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66440990	66440990	+	Silent	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr5:66440990C>T	ENST00000404260.3	+	23	3194	c.2886C>T	c.(2884-2886)tcC>tcT	p.S962S	MAST4_ENST00000403625.2_Silent_p.S959S|MAST4_ENST00000405643.1_Silent_p.S780S|MAST4_ENST00000403666.1_Silent_p.S770S|MAST4_ENST00000261569.7_Silent_p.S765S			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	962						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TATCAACATCCAACTCTTCAG	0.383000													4	10					0	0	1	0	0
TTC31	64427	broad.mit.edu	37	2	74717852	74717852	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr2:74717852C>T	ENST00000410003.1	+	5	541	c.532C>T	c.(532-534)Cga>Tga	p.R178*	TTC31_ENST00000233623.5_Nonsense_Mutation_p.R178*|TTC31_ENST00000442235.2_Nonsense_Mutation_p.R34*|TTC31_ENST00000463189.1_3'UTR			Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	178							binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9						AGAGAAAAAGCGACTCAAGAA	0.547000													5	10					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118968583	118968583	+	Splice_Site	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr5:118968583G>A	ENST00000515256.1	+	2	383	c.211G>A	c.(211-213)Gga>Aga	p.G71R				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	71						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						CATCCACAGTGGTAAGGGTGC	0.537000													18	26					0	0	1	0	0
DHX8	1659	broad.mit.edu	37	17	41598929	41598929	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr17:41598929G>A	ENST00000262415.3	+	21	3331	c.3259G>A	c.(3259-3261)Gac>Aac	p.D1087N	DHX8_ENST00000540306.1_Missense_Mutation_p.D1087N	NM_004941.1	NP_004932.1	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	1087						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		AGGCATAATGGACAGGTAAGC	0.473000													19	64					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94708167	94708167	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr14:94708167A>G	ENST00000304338.3	+	10	1173	c.1019A>G	c.(1018-1020)tAt>tGt	p.Y340C		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	340						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TTGGAATTTTATAAGAAACTT	0.308000													16	26					0	0	1	0	0
SLC37A2	219855	broad.mit.edu	37	11	124955360	124955360	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr11:124955360G>A	ENST00000403796.2	+	15	1619	c.1318G>A	c.(1318-1320)Ggc>Agc	p.G440S	SLC37A2_ENST00000525837.1_3'UTR|SLC37A2_ENST00000407458.1_Missense_Mutation_p.G440S|SLC37A2_ENST00000298280.5_3'UTR|SLC37A2_ENST00000308074.4_Missense_Mutation_p.G440S	NM_001145290.1	NP_001138762.1	Q8TED4	SPX2_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 2	440					carbohydrate transport|transmembrane transport	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	27	all_hematologic(175;0.215)	Breast(109;0.012)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.152)|all_lung(97;0.159)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0384)		TGACGGCACCGGCTCCATAGG	0.642000													5	18					0	0	1	0	0
SERBP1	26135	broad.mit.edu	37	1	67895855	67895855	+	Silent	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr1:67895855C>T	ENST00000370994.4	-	1	243	c.129G>A	c.(127-129)ggG>ggA	p.G43G	SERBP1_ENST00000370995.2_Silent_p.G43G|SERBP1_ENST00000370990.5_Silent_p.G43G|SERBP1_ENST00000361219.6_Silent_p.G43G	NM_001018067.1|NM_001018068.1|NM_001018069.1|NM_015640.3	NP_001018077.1|NP_001018078.1|NP_001018079.1|NP_056455.3	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1	43					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	13						CAACGCCGCCCCCGCCGGCTT	0.627000													4	65					0	0	1	0	0
NKAIN2	154215	broad.mit.edu	37	6	124979592	124979592	+	Silent	SNP	G	G	C			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr6:124979592G>C	ENST00000368416.1	+	4	594	c.534G>C	c.(532-534)gcG>gcC	p.A178A	NKAIN2_ENST00000368417.1_Intron|NKAIN2_ENST00000545433.1_Intron|NKAIN2_ENST00000546092.1_Intron			Q5VXU1	NKAI2_HUMAN	Na+/K+ transporting ATPase interacting 2	5						integral to membrane|plasma membrane				cervix(1)|endometrium(1)|large_intestine(3)|lung(12)|skin(2)	19				GBM - Glioblastoma multiforme(226;0.104)		ATTTCTGTGCGAACTCAGTGC	0.443000													13	12					0	0	1	0	0
AFG3L2	10939	broad.mit.edu	37	18	12351323	12351323	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr18:12351323C>A	ENST00000269143.3	-	11	1639	c.1408G>T	c.(1408-1410)Gac>Tac	p.D470Y		NM_006796.2	NP_006787.2	Q9Y4W6	AFG32_HUMAN	AFG3-like AAA ATPase 2	470					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|prostate(3)|skin(1)|stomach(3)|urinary_tract(1)	27					Adenosine triphosphate(DB00171)	ATCTGCCTGTCGAAACGCCCC	0.458000													13	22					1.5842e-08	1.65384e-08	1	1	0
GRIA2	2891	broad.mit.edu	37	4	158257894	158257894	+	Silent	SNP	G	G	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr4:158257894G>T	ENST00000296526.7	+	11	2164	c.1839G>T	c.(1837-1839)tcG>tcT	p.S613S	GRIA2_ENST00000507898.1_Silent_p.S566S|GRIA2_ENST00000449365.1_Silent_p.S566S|GRIA2_ENST00000393815.2_Silent_p.S566S|GRIA2_ENST00000264426.9_Silent_p.S613S	NM_000826.3	NP_000817	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	613					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GCGATATTTCGCCAAGGTTGG	0.413000													48	65					6.31075e-24	7.4015e-24	1	1	0
ZFYVE26	23503	broad.mit.edu	37	14	68222855	68222855	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr14:68222855G>A	ENST00000347230.4	-	36	6734	c.6596C>T	c.(6595-6597)cCt>cTt	p.P2199L	ZFYVE26_ENST00000557306.1_Missense_Mutation_p.P45L	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2199					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AACTTCTGGAGGACTCTCCTG	0.463000													65	99					0	0	1	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162614	33162614	+	RNA	SNP	G	G	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr5:33162614G>A	ENST00000510327.1	-	0	346																											ACACCGTGCCGACAGTGGTAA	0.483000													5	13					0	0	1	0	0
ZNF780A	284323	broad.mit.edu	37	19	40580440	40580440	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr19:40580440C>T	ENST00000450241.2	-	6	2118	c.1807G>A	c.(1807-1809)Ggt>Agt	p.G603S	ZNF780A_ENST00000594395.1_Missense_Mutation_p.G638S|ZNF780A_ENST00000340963.5_Missense_Mutation_p.G637S|AC005614.5_ENST00000595508.1_RNA|ZNF780A_ENST00000595687.2_Missense_Mutation_p.G637S|ZNF780A_ENST00000455521.1_Missense_Mutation_p.G638S|ZNF780A_ENST00000414720.2_Intron			O75290	Z780A_HUMAN	zinc finger protein 780A	637					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GCCTTCTCACCTGTGTGAATG	0.408000													35	52					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1918064	1918064	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr20:1918064C>A	ENST00000358771.4	+	8	1517	c.1365C>A	c.(1363-1365)agC>agA	p.S455R	SIRPA_ENST00000400068.3_Missense_Mutation_p.S459R|SIRPA_ENST00000356025.3_Missense_Mutation_p.S455R	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	455					blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		AGTATGCCAGCATTCAGACCA	0.617000													18	23					1.99824e-07	2.0634e-07	1	1	0
NR1I2	8856	broad.mit.edu	37	3	119534285	119534285	+	Splice_Site	SNP	A	A	G			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr3:119534285A>G	ENST00000393716.2	+	7	2892	c.1053A>G	c.(1051-1053)ccA>ccG	p.P351P	NR1I2_ENST00000466380.1_Splice_Site_p.P314P|NR1I2_ENST00000337940.4_Splice_Site_p.P390P	NM_003889.3	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	351	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	TCTTCTCCCCAGGTGAGGATC	0.572000													21	30					0	0	1	0	0
GPX7	2882	broad.mit.edu	37	1	53072617	53072617	+	Splice_Site	SNP	C	C	G			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr1:53072617C>G	ENST00000361314.4	+	2	438	c.400C>G	c.(400-402)Cag>Gag	p.Q134E	GPX7_ENST00000459779.1_3'UTR	NM_015696.4	NP_056511.2	Q96SL4	GPX7_HUMAN	glutathione peroxidase 7	134					response to oxidative stress	extracellular region	glutathione peroxidase activity			breast(1)|kidney(1)|lung(4)|upper_aerodigestive_tract(1)	7					Glutathione(DB00143)	GTACCTGGCCCGTAAGTCCTG	0.597000													5	100					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16464417	16464417	+	Frame_Shift_Del	DEL	G	G	-	rs150826389		TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr1:16464417delG	ENST00000358432.5	-	5	1397	c.1243delC	c.(1243-1245)cgcfs	p.R415fs		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	415	Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	ACGCCATTGCGGGCCTCCACG	0.622													15	28	---	---	---	---					
CAMSAP2	23271	broad.mit.edu	37	1	200818513	200818519	+	Frame_Shift_Del	DEL	AAATGAA	AAATGAA	-			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr1:200818513_200818519delAAATGAA	ENST00000358823.2	+	11	2886_2892	c.2616_2622delAAATGAA	c.(2614-2622)ttaaatgaafs	p.LNE872fs	CAMSAP2_ENST00000236925.4_Frame_Shift_Del_p.LNE883fs|CAMSAP2_ENST00000413307.2_Frame_Shift_Del_p.LNE856fs	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	883						cytoplasm|microtubule	protein binding	p.E874*(1)									AAGAAACTTTAAATGAAGGAGAGATTT	0.406													32	84	---	---	---	---					
ASIC4	55515	broad.mit.edu	37	2	220402688	220402688	+	Frame_Shift_Del	DEL	G	G	-	rs115824877	byFrequency	TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr2:220402688delG	ENST00000358078.4	+	10	1935	c.1921delG	c.(1921-1923)gggfs	p.G642fs	ASIC4_ENST00000347842.3_Frame_Shift_Del_p.G623fs			Q96FT7	ACCN4_HUMAN	acid-sensing (proton-gated) ion channel family member 4	623						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										AGTGGAGGGTGGGGGGGTCAG	0.627													3	6	---	---	---	---					
AGFG1	3267	broad.mit.edu	37	2	228398355	228398355	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr2:228398355delC	ENST00000310078.8	+	7	1165	c.905delC	c.(904-906)tccfs	p.S302fs	AGFG1_ENST00000409171.1_Frame_Shift_Del_p.S302fs|AGFG1_ENST00000373671.3_Frame_Shift_Del_p.S262fs|AGFG1_ENST00000409979.2_Frame_Shift_Del_p.S326fs|AGFG1_ENST00000409315.1_Frame_Shift_Del_p.S302fs	NM_001135188.1|NM_001135189.1|NM_004504.4	NP_001128660.1|NP_001128661.1|NP_004495.2	P52594	AGFG1_HUMAN	ArfGAP with FG repeats 1						cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(2)|ovary(1)|prostate(1)|skin(4)|stomach(1)	18						TTCAATACTTCCCAGAGTCAT	0.393													26	53	---	---	---	---					
KANK1	23189	broad.mit.edu	37	9	738496	738497	+	Frame_Shift_Ins	INS	-	-	AGATG			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr9:738496_738497insAGATG	ENST00000382303.1	+	12	4197_4198	c.3545_3546insAGATG	c.(3544-3549)ttagatfs	p.-1183fs	KANK1_ENST00000382293.3_Frame_Shift_Ins_p.-1025fs|KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382297.2_Frame_Shift_Ins_p.-1183fs	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1						negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		AAGCTGCTGTTAGATGCCGGTA	0.520													8	30	---	---	---	---					
HGS	9146	broad.mit.edu	37	17	79663729	79663729	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XF-AAMH-01A-11D-A42E-08	TCGA-XF-AAMH-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bb07f28-fa98-4583-bbd5-4a38ca63b306	2226b682-b9de-450c-85e0-204ddd200a78	g.chr17:79663729delG	ENST00000329138.4	+	17	1794	c.1659delG	c.(1657-1659)acgfs	p.T553fs		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	553	Gln-rich.|Interaction with NF2.|Interaction with STAM1 (By similarity).				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			AGAAGCAGACGGTCCAGATGC	0.672													13	44	---	---	---	---					
