Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IKBKAP	8518	broad.mit.edu	37	9	111658811	111658811	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr9:111658811C>G	ENST00000374647.5	-	25	3008	c.2701G>C	c.(2701-2703)Gat>Cat	p.D901H	IKBKAP_ENST00000537196.1_Missense_Mutation_p.D552H	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	901					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AGGACCAAATCAAAGTCATAG	0.388000													27	8					0	0	1	0	0
BPIFA1	51297	broad.mit.edu	37	20	31830315	31830315	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr20:31830315G>C	ENST00000354297.4	+	8	824	c.753G>C	c.(751-753)caG>caC	p.Q251H	BPIFA1_ENST00000375413.4_Missense_Mutation_p.Q251H|BPIFA1_ENST00000375422.2_Missense_Mutation_p.Q251H	NM_130852.2	NP_570913.1	Q9NP55	PLUNC_HUMAN	BPI fold containing family A, member 1	251					innate immune response	extracellular region	lipid binding										ACGGACTACAGTTTGTCATCA	0.493000													27	47					0	0	1	0	0
ERICH1	157697	broad.mit.edu	37	8	623493	623493	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr8:623493C>A	ENST00000262109.7	-	4	936	c.859G>T	c.(859-861)Gag>Tag	p.E287*	ERICH1_ENST00000522706.1_Nonsense_Mutation_p.E193*	NM_207332.1	NP_997215.1	Q86X53	ERIC1_HUMAN	glutamate-rich 1	287	Glu-rich.									endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)	20		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		CCGTCTTCCTCCCCGGCCCGT	0.642000													66	97					1.88737e-50	2.05723e-50	1	1	0
PIK3CA	5290	broad.mit.edu	37	3	178938934	178938934	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:178938934G>A	ENST00000263967.3	+	14	2333	c.2176G>A	c.(2176-2178)Gaa>Aaa	p.E726K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	726					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E726K(8)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAGAAGGATGAAACACAAAA	0.428000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			22	34					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225698895	225698895	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr2:225698895T>C	ENST00000409592.3	-	26	3031	c.2918A>G	c.(2917-2919)gAc>gGc	p.D973G	DOCK10_ENST00000258390.7_Missense_Mutation_p.D979G			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	979							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TGTTGTTGAGTCATTTGATTT	0.408000													18	51					0	0	1	0	0
C1orf63	57035	broad.mit.edu	37	1	25573295	25573295	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:25573295A>C	ENST00000243189.7	-	2	436	c.160T>G	c.(160-162)Tcg>Gcg	p.S54A	C1orf63_ENST00000431849.2_Missense_Mutation_p.S54A|C1orf63_ENST00000417642.2_Missense_Mutation_p.S47A	NM_020317.3	NP_064713.3	Q9BUV0	CA063_HUMAN	chromosome 1 open reading frame 63	54	Arg-rich.									breast(1)|large_intestine(1)|lung(4)|pancreas(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.9e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000333)|BRCA - Breast invasive adenocarcinoma(304;0.000443)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000932)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CTCCTGGACGAAAACCGGCTC	0.672000													39	54					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17083776	17083776	+	RNA	SNP	C	C	A	rs56318124		TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:17083776C>A	ENST00000455405.2	-	0	812																		p.R674L(1)									CACAGAGACACGCGTGAAGAC	0.537000													4	13					0.0381472	0.0381472	1	1	0
UBXN6	80700	broad.mit.edu	37	19	4446708	4446708	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:4446708C>T	ENST00000301281.6	-	8	833	c.709G>A	c.(709-711)Gag>Aag	p.E237K	UBXN6_ENST00000394765.3_Missense_Mutation_p.E184K	NM_025241.2	NP_079517.1	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	237	PUB.					microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	12						TAGAACTCCTCGGGGTCCTCT	0.667000													23	30					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43230540	43230540	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr21:43230540C>T	ENST00000422911.1	-	22	2894	c.2793G>A	c.(2791-2793)atG>atA	p.M931I	PRDM15_ENST00000470586.1_5'UTR|PRDM15_ENST00000398548.1_Missense_Mutation_p.M911I|PRDM15_ENST00000269844.3_Missense_Mutation_p.M1240I|PRDM15_ENST00000447207.2_Missense_Mutation_p.M874I|PRDM15_ENST00000538201.1_Missense_Mutation_p.M894I	NM_001282934.1	NP_001269863.1	P57071	PRD15_HUMAN	PR domain containing 15	1240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						TGTGTCGGCTCATGGAGGCCC	0.687000													9	23					0	0	1	0	0
ZNF337	26152	broad.mit.edu	37	20	25656702	25656702	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr20:25656702C>A	ENST00000376436.1	-	4	1761	c.1222G>T	c.(1222-1224)Gat>Tat	p.D408Y	ZNF337_ENST00000538750.1_Missense_Mutation_p.D376Y|RP4-694B14.5_ENST00000414393.1_RNA|RP4-694B14.5_ENST00000439498.1_RNA|RP4-694B14.5_ENST00000455791.1_RNA|ZNF337_ENST00000252979.5_Missense_Mutation_p.D408Y					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CGCTCACAATCCTTGCACACA	0.478000													13	73					4.3838e-07	4.44497e-07	1	1	0
TTN	7273	broad.mit.edu	37	2	179556760	179556760	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr2:179556760G>C	ENST00000589042.1	-	121	31969	c.31745C>G	c.(31744-31746)cCt>cGt	p.P10582R	TTN_ENST00000591111.1_Missense_Mutation_p.P10265R|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P9338R|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10265	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGAGCAGCAGGTTCCTTCTT	0.463000													13	34					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10216024	10216024	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:10216024G>A	ENST00000418404.3	-	30	4395	c.4232C>T	c.(4231-4233)gCg>gTg	p.A1411V	RP11-401O9.4_ENST00000609088.1_RNA|MYH13_ENST00000252172.4_Missense_Mutation_p.A1411V			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1411					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CTTGGAGTTCGCCGTCTCCGT	0.542000													19	11					0	0	1	0	0
PPID	5481	broad.mit.edu	37	4	159640404	159640404	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:159640404G>C	ENST00000307720.3	-	3	368	c.261C>G	c.(259-261)ttC>ttG	p.F87L		NM_005038.2	NP_005029.1	Q08752	PPID_HUMAN	peptidylprolyl isomerase D	87	PPIase cyclophilin-type.				protein folding	cytoplasm|intermediate filament cytoskeleton	cyclosporin A binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0159)		TCTGATTTGAGAAGTCTCCAC	0.338000													32	9					0	0	1	0	0
LINC00639	283547	broad.mit.edu	37	14	39304899	39304899	+	RNA	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr14:39304899C>T	ENST00000553932.1	-	0	3663																											AGACCACATTCGCCATCAGAG	0.502000													5	14					0	0	1	0	0
EXOC7	23265	broad.mit.edu	37	17	74097785	74097785	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:74097785C>T	ENST00000607838.1	-	3	380	c.286G>A	c.(286-288)Gac>Aac	p.D96N	EXOC7_ENST00000335146.7_Missense_Mutation_p.D96N|EXOC7_ENST00000332065.5_Missense_Mutation_p.D96N|EXOC7_ENST00000411744.2_Missense_Mutation_p.D96N|EXOC7_ENST00000406660.3_Missense_Mutation_p.D96N|EXOC7_ENST00000467929.2_Missense_Mutation_p.D55N|EXOC7_ENST00000405575.4_Missense_Mutation_p.D96N|EXOC7_ENST00000589210.1_Missense_Mutation_p.D96N	NM_001145297.2|NM_001145298.2|NM_001145299.2	NP_001138769.1|NP_001138770.1|NP_001138771.1	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7	96					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	14			LUSC - Lung squamous cell carcinoma(166;0.187)			TTCTCAGTGTCACTGGCCACA	0.547000													70	69					0	0	1	0	0
HTR3D	200909	broad.mit.edu	37	3	183756605	183756605	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:183756605G>A	ENST00000382489.3	+	8	1207	c.1207G>A	c.(1207-1209)Gaa>Aaa	p.E403K	HTR3D_ENST00000453435.1_Missense_Mutation_p.E182K|HTR3D_ENST00000334128.2_Missense_Mutation_p.E228K|HTR3D_ENST00000428798.2_Missense_Mutation_p.E353K	NM_001163646.1	NP_001157118.1	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	403						integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)	10	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGGGGGCTCAGAATGGACAAG	0.632000													17	18					0	0	1	0	0
C9orf41	138199	broad.mit.edu	37	9	77614757	77614757	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr9:77614757G>C	ENST00000376834.3	-	4	772	c.620C>G	c.(619-621)cCt>cGt	p.P207R	C9orf41_ENST00000376837.3_Intron	NM_152420.1	NP_689633.1	Q8N4J0	CI041_HUMAN	chromosome 9 open reading frame 41	207										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|urinary_tract(2)	17						TCCAGCACCAGGTACCAGAAT	0.373000													43	16					0	0	1	0	0
MAGED1	9500	broad.mit.edu	37	X	51640908	51640908	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chrX:51640908G>A	ENST00000375695.2	+	8	1905	c.1752G>A	c.(1750-1752)ctG>ctA	p.L584L	MAGED1_ENST00000375772.3_Silent_p.L528L|MAGED1_ENST00000375722.1_Silent_p.L528L|MAGED1_ENST00000326587.7_Silent_p.L528L|MAGED1_ENST00000494718.1_3'UTR	NM_001005333.1	NP_001005333.1	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1	528	MAGE.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			breast(1)|endometrium(4)|large_intestine(10)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	32	Ovarian(276;0.236)					GGATTCAACTGAAAGAAATTG	0.433000										Multiple Myeloma(10;0.10)			15	0					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136700666	136700666	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr7:136700666C>G	ENST00000445907.2	+	3	1582	c.1054C>G	c.(1054-1056)Cag>Gag	p.Q352E	hsa-mir-490_ENST00000598184.1_RNA|hsa-mir-490_ENST00000597642.1_RNA|hsa-mir-490_ENST00000592183.1_RNA|CHRM2_ENST00000320658.5_Missense_Mutation_p.Q352E|hsa-mir-490_ENST00000425981.2_RNA|hsa-mir-490_ENST00000593789.1_RNA|hsa-mir-490_ENST00000586239.1_RNA|CHRM2_ENST00000397608.3_Missense_Mutation_p.Q352E|CHRM2_ENST00000402486.3_Missense_Mutation_p.Q352E|CHRM2_ENST00000401861.1_Missense_Mutation_p.Q352E|CHRM2_ENST00000453373.1_Missense_Mutation_p.Q352E|hsa-mir-490_ENST00000439694.1_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	352					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	GTCTTCAGGTCAGAATGGAGA	0.463000													14	39					0	0	1	0	0
ITPA	3704	broad.mit.edu	37	20	3193862	3193862	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr20:3193862G>A	ENST00000380113.3	+	2	306	c.114G>A	c.(112-114)caG>caA	p.Q38Q	ITPA_ENST00000399838.3_Intron|ITPA_ENST00000483354.1_3'UTR|ITPA_ENST00000455664.2_Silent_p.Q21Q	NM_033453.3|NM_181493.2	NP_258412.1|NP_852470.1	Q9BY32	ITPA_HUMAN	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	38					nucleotide metabolic process	cytoplasm	metal ion binding|nucleoside-triphosphate diphosphatase activity|nucleotide binding			autonomic_ganglia(1)|large_intestine(3)|ovary(1)|stomach(1)	6						TGGTGGCACAGAAAATTGACC	0.393000													59	125					0	0	1	0	0
CDKN1A	1026	broad.mit.edu	37	6	36652260	36652260	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:36652260G>A	ENST00000405375.1	+	2	617	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	CDKN1A_ENST00000448526.2_Missense_Mutation_p.E162K|CDKN1A_ENST00000373711.2_Missense_Mutation_p.E128K|CDKN1A_ENST00000244741.5_Missense_Mutation_p.E128K|CDKN1A_ENST00000478800.1_3'UTR	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	128					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						GGAGCAGGCTGAAGGGTCCCC	0.612000													14	10					0	0	1	0	0
EXOC7	23265	broad.mit.edu	37	17	74097438	74097438	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:74097438C>G	ENST00000607838.1	-	4	425	c.331G>C	c.(331-333)Gag>Cag	p.E111Q	EXOC7_ENST00000335146.7_Missense_Mutation_p.E111Q|EXOC7_ENST00000332065.5_Missense_Mutation_p.E111Q|EXOC7_ENST00000411744.2_Missense_Mutation_p.E111Q|EXOC7_ENST00000406660.3_Missense_Mutation_p.E111Q|EXOC7_ENST00000467929.2_Missense_Mutation_p.E70Q|EXOC7_ENST00000405575.4_Missense_Mutation_p.E111Q|EXOC7_ENST00000589210.1_Missense_Mutation_p.E111Q	NM_001145297.2|NM_001145298.2|NM_001145299.2	NP_001138769.1|NP_001138770.1|NP_001138771.1	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7	111					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	14			LUSC - Lung squamous cell carcinoma(166;0.187)			CCCAGGTACTCTTCCAGCCTA	0.527000													60	65					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065434	9065434	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:9065434C>T	ENST00000397910.4	-	3	22215	c.22012G>A	c.(22012-22014)Gag>Aag	p.E7338K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7340	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAGGTACTCTCTGATGTAGAC	0.443000													22	30					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038010	75038010	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:75038010G>A	ENST00000326665.5	-	14	3602	c.3384C>T	c.(3382-3384)aaC>aaT	p.N1128N	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1128	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CAGGTGCTTCGTTCTCAGCAT	0.463000													33	70					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173939703	173939703	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:173939703C>G	ENST00000367696.2	-	9	1625	c.1274G>C	c.(1273-1275)aGa>aCa	p.R425T	RC3H1_ENST00000258349.4_Missense_Mutation_p.R425T|RC3H1_ENST00000367694.2_Missense_Mutation_p.R425T			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	425					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						GCATCCTCCTCTCTGCTTCAT	0.428000													40	81					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189608623	189608623	+	Silent	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:189608623G>C	ENST00000264731.3	+	13	1787	c.1698G>C	c.(1696-1698)acG>acC	p.T566T	TP63_ENST00000320472.5_Intron|TP63_ENST00000392460.3_Intron|TP63_ENST00000449992.1_Silent_p.T387T|TP63_ENST00000392461.3_Intron|TP63_ENST00000440651.2_Silent_p.T562T|TP63_ENST00000382063.4_Silent_p.T481T|TP63_ENST00000392463.2_Intron|TP63_ENST00000354600.5_Silent_p.T472T|TP63_ENST00000456148.1_Silent_p.T468T	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	566	SAM.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACTATTTCACGACCCAGGGGC	0.433000										HNSCC(45;0.13)			57	76					0	0	1	0	0
LPCAT1	79888	broad.mit.edu	37	5	1466949	1466949	+	Silent	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr5:1466949G>C	ENST00000283415.3	-	13	1467	c.1335C>G	c.(1333-1335)ctC>ctG	p.L445L	LPCAT1_ENST00000503252.1_5'UTR	NM_024830.3	NP_079106.3	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	445					phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		GGGCCGTCTTGAGGATGCAGG	0.622000													23	48					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178938886	178938886	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:178938886G>C	ENST00000263967.3	+	14	2285	c.2128G>C	c.(2128-2130)Gaa>Caa	p.E710Q		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	710					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CGAGGCAATGGAAAAGCTCAT	0.418000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			29	31					0	0	1	0	0
RPN2	6185	broad.mit.edu	37	20	35860769	35860769	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr20:35860769C>A	ENST00000237530.6	+	14	1963	c.1652C>A	c.(1651-1653)tCg>tAg	p.S551*	RPN2_ENST00000470352.1_Intron|RPN2_ENST00000373622.5_Nonsense_Mutation_p.S519*	NM_002951.3	NP_002942.2	P04844	RPN2_HUMAN	ribophorin II	551					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|skin(2)|stomach(1)	24		Myeloproliferative disorder(115;0.00878)				CTGATCCTCTCGCCGTTGCTT	0.577000													62	96					2.05175e-36	2.21427e-36	1	1	0
ITK	3702	broad.mit.edu	37	5	156608027	156608027	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr5:156608027G>C	ENST00000422843.3	+	1	191	c.39G>C	c.(37-39)aaG>aaC	p.K13N		NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	13	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGCTCATCAAGAAATCCCAAC	0.448000			T	SYK	peripheral T-cell lymphoma								4	81					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44910952	44910952	+	Splice_Site	SNP	A	A	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chrX:44910952A>G	ENST00000377967.4	+	9	695		c.e9-1		KDM6A_ENST00000382899.4_Splice_Site|KDM6A_ENST00000543216.1_Splice_Site|KDM6A_ENST00000536777.1_Splice_Site	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.0(4)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TCTGTTCTTTAGAGGAAATAT	0.289000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								29	9					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52575092	52575092	+	Splice_Site	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr18:52575092T>C	ENST00000591504.1	-	11	1149	c.875A>G	c.(874-876)aAt>aGt	p.N292S	CCDC68_ENST00000337363.4_Splice_Site_p.N292S|CCDC68_ENST00000432185.1_Splice_Site_p.N292S	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	292										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		TAGTTCTTTATTCTAAAATTG	0.413000													13	36					0	0	1	0	0
CCDC151	115948	broad.mit.edu	37	19	11537746	11537746	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:11537746G>A	ENST00000356392.4	-	4	646	c.559C>T	c.(559-561)Ctg>Ttg	p.L187L	CCDC151_ENST00000545100.1_Silent_p.L133L|CCDC151_ENST00000591179.1_Silent_p.L161L|CCDC151_ENST00000586836.1_5'UTR	NM_145045.4	NP_659482.3	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	187										endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	12						AGAAGGCGCAGGCTGTGCTGC	0.667000													8	49					0	0	1	0	0
TDRD3	81550	broad.mit.edu	37	13	61034520	61034520	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr13:61034520G>C	ENST00000535286.1	+	4	271	c.199G>C	c.(199-201)Ggt>Cgt	p.G67R	TDRD3_ENST00000463109.1_3'UTR|TDRD3_ENST00000377894.2_5'UTR|TDRD3_ENST00000377881.2_5'UTR|TDRD3_ENST00000196169.3_5'UTR	NM_001146070.1	NP_001139542.1	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3	0					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	40		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		ACAGCTCGAAGGTCCATGTGT	0.368000													4	32					0	0	1	0	0
VSTM4	196740	broad.mit.edu	37	10	50315779	50315779	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:50315779C>A	ENST00000332853.4	-	2	340	c.317G>T	c.(316-318)cGg>cTg	p.R106L	VSTM4_ENST00000298454.3_Missense_Mutation_p.R106L	NM_001031746.3	NP_001026916.2	Q8IW00	CJ072_HUMAN	V-set and transmembrane domain containing 4		Ig-like.					integral to membrane|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|skin(2)	31						GAGCGCCCCCCGCTGCTCCTC	0.607000													11	62					2.80697e-09	2.88642e-09	1	1	0
TALDO1	6888	broad.mit.edu	37	11	763868	763868	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr11:763868C>T	ENST00000319006.3	+	6	912	c.759C>T	c.(757-759)ctC>ctT	p.L253L	TALDO1_ENST00000528097.1_Silent_p.L253L			P37837	TALDO_HUMAN	transaldolase 1	253					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(2)	14		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		GTGACTTCCTCACCATCTCAC	0.582000													52	11					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78513215	78513215	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:78513215C>G	ENST00000397909.2	+	15	3412	c.3239C>G	c.(3238-3240)aCc>aGc	p.T1080S	NAV3_ENST00000536525.2_Missense_Mutation_p.T1080S|NAV3_ENST00000266692.7_Missense_Mutation_p.T1080S|NAV3_ENST00000228327.6_Missense_Mutation_p.T1080S			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1080	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GCCATGATCACCAGCAGTGGA	0.498000										HNSCC(70;0.22)			41	64					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236923046	236923046	+	Missense_Mutation	SNP	A	A	T	rs147616930		TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:236923046A>T	ENST00000366578.4	+	19	2490	c.2324A>T	c.(2323-2325)cAt>cTt	p.H775L	ACTN2_ENST00000546208.1_Missense_Mutation_p.H269L|ACTN2_ENST00000542672.1_Missense_Mutation_p.H775L	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	775	EF-hand 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CTGATGGATCATGAGGATTTC	0.408000													5	111					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	50					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35579967	35579967	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr20:35579967G>A	ENST00000262878.4	-	1	279	c.80C>T	c.(79-81)tCc>tTc	p.S27F	SAMHD1_ENST00000373694.5_5'UTR	NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	27					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				TGCCTCTGCGGAAGGGGTGTT	0.647000													120	157					0	0	1	0	0
MTERF	7978	broad.mit.edu	37	7	91504047	91504047	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr7:91504047T>C	ENST00000351870.3	-	3	154	c.61A>G	c.(61-63)Atg>Gtg	p.M21V	MTERF_ENST00000406735.2_Start_Codon_SNP_p.M1V|MTERF_ENST00000419292.1_Start_Codon_SNP_p.M1V	NM_006980.3	NP_008911.1	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	21					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|skin(1)	14	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			CCTGGTGCCATAATGGTTAGG	0.333000													11	41					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161527725	161527725	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:161527725G>A	ENST00000392142.4	+	20	4184	c.4036G>A	c.(4036-4038)Gga>Aga	p.G1346R	MAP3K4_ENST00000366919.2_Missense_Mutation_p.G1296R|MAP3K4_ENST00000348824.7_Missense_Mutation_p.G1292R|MAP3K4_ENST00000366920.2_Missense_Mutation_p.G1342R	NM_005922.2	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1346	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		ATGGCAAAGAGGAAACAAAAT	0.378000													29	16					0	0	1	0	0
PPM1D	8493	broad.mit.edu	37	17	58740747	58740747	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:58740747G>C	ENST00000305921.3	+	6	1884	c.1652G>C	c.(1651-1653)aGa>aCa	p.R551T		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	551					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			AAGAAGCATAGACGAAATGGC	0.468000											OREG0031485	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	46	49					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101110332	101110332	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:101110332C>T	ENST00000369162.2	-	15	2711	c.2367G>A	c.(2365-2367)caG>caA	p.Q789Q		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	789	Helicase C-terminal 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		AATTTCTGTCCTGCCGAAGCA	0.423000													8	36					0	0	1	0	0
IL2	3558	broad.mit.edu	37	4	123373004	123373004	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:123373004G>A	ENST00000226730.4	-	4	649	c.365C>T	c.(364-366)aCa>aTa	p.T122I		NM_000586.3	NP_000577.2	P60568	IL2_HUMAN	interleukin 2	122					anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity			endometrium(2)|large_intestine(4)|lung(6)|skin(1)	13				LUSC - Lung squamous cell carcinoma(721;0.185)		ACACATGAATGTTGTTTCAGA	0.323000			T	TNFRSF17	intestinal T-cell lymphoma								3	35					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61815664	61815664	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:61815664C>A	ENST00000280772.2	-	42	13008	c.12817G>T	c.(12817-12819)Gat>Tat	p.D4273Y	ANK3_ENST00000355288.2_Missense_Mutation_p.D897Y|ANK3_ENST00000503366.1_Missense_Mutation_p.D1764Y|ANK3_ENST00000373827.2_Missense_Mutation_p.D1757Y|RP11-388P9.2_ENST00000414383.1_RNA	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTCCTACATCATTTTGGGAT	0.388000													45	91					2.55665e-31	2.74556e-31	1	1	0
MRC1	4360	broad.mit.edu	37	10	18138626	18138626	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:18138626A>C	ENST00000239761.3	+	7	1285	c.1182A>C	c.(1180-1182)gaA>gaC	p.E394D		NM_002438.2	NP_002429.1	P22897	MRC1_HUMAN	mannose receptor, C type 1	394	C-type lectin 2.				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity			breast(1)|kidney(1)|lung(2)|prostate(1)|urinary_tract(1)	6						GCAGGAAGGAAGGCGGTGACC	0.468000													45	102					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24567013	24567013	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr16:24567013C>G	ENST00000319715.4	+	5	858	c.426C>G	c.(424-426)taC>taG	p.Y142*	RBBP6_ENST00000348022.2_Nonsense_Mutation_p.Y142*|RBBP6_ENST00000381039.3_Nonsense_Mutation_p.Y142*	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	142					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		GCCATGAATACGACCCAATCA	0.368000													8	79					0	0	1	0	0
SCNM1	79005	broad.mit.edu	37	1	151138954	151138954	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:151138954G>C	ENST00000368905.4	+	2	170	c.59G>C	c.(58-60)aGa>aCa	p.R20T	SCNM1_ENST00000461862.1_3'UTR	NM_001204856.1|NM_024041.3	NP_001191785.1|NP_076946.1	Q9BWG6	SCNM1_HUMAN	sodium channel modifier 1	20					mRNA processing|RNA splicing	nucleus	metal ion binding|protein binding	p.R20K(1)		breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	17	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CAGAAAAGAAGAGTCGGGGAC	0.527000													3	14					0	0	1	0	0
ZRANB2	9406	broad.mit.edu	37	1	71536642	71536642	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:71536642T>C	ENST00000370920.3	-	7	852	c.551A>G	c.(550-552)aAt>aGt	p.N184S	ZRANB2_ENST00000254821.6_Missense_Mutation_p.N184S	NM_203350.2	NP_976225.1	O95218	ZRAB2_HUMAN	zinc finger, RAN-binding domain containing 2	184	Required for nuclear targeting.				mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|stomach(1)	15						GGCATCAAGATTATATTTTGA	0.333000													20	38					0	0	1	0	0
CCR10	2826	broad.mit.edu	37	17	40831703	40831703	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:40831703C>T	ENST00000591765.1	-	2	1676	c.291G>A	c.(289-291)caG>caA	p.Q97Q	CCR10_ENST00000332438.4_Silent_p.Q319Q			P46092	CCR10_HUMAN	chemokine (C-C motif) receptor 10	319						integral to plasma membrane				lung(1)|ovary(1)|skin(1)	3		Breast(137;0.000153)		BRCA - Breast invasive adenocarcinoma(366;0.14)		TCCGCAGGTCCTGGCGGAAGC	0.706000													9	12					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103029793	103029793	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr7:103029793T>C	ENST00000306312.3	-	13	1651	c.1390A>G	c.(1390-1392)Acc>Gcc	p.T464A	SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000393727.1_Missense_Mutation_p.T464A|SLC26A5_ENST00000393723.1_Intron|SLC26A5_ENST00000393730.1_Intron|SLC26A5_ENST00000393729.1_Missense_Mutation_p.T427A|SLC26A5_ENST00000432958.2_Intron|SLC26A5_ENST00000393735.2_Missense_Mutation_p.T464A|SLC26A5_ENST00000339444.6_Missense_Mutation_p.T464A|SLC26A5_ENST00000356767.4_Intron	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	464					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						ATTTTGCTGGTTCTCCAGAAA	0.413000													15	70					0	0	1	0	0
CCDC155	147872	broad.mit.edu	37	19	49920479	49920479	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:49920479G>C	ENST00000447857.3	+	19	1708	c.1503G>C	c.(1501-1503)agG>agC	p.R501S		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	501						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						TCCCAGTCAGGAGGAGGGCCT	0.632000													18	19					0	0	1	0	0
CEP97	79598	broad.mit.edu	37	3	101450783	101450783	+	Silent	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:101450783C>A	ENST00000341893.3	+	5	1299	c.547C>A	c.(547-549)Cga>Aga	p.R183R	CEP97_ENST00000327230.4_Silent_p.R183R|CEP97_ENST00000494050.1_Silent_p.R183R			Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	183						centrosome|nucleus	protein binding			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29						AAATGAAATCCGAGACTTAAA	0.413000													54	72					9.72345e-25	1.02899e-24	1	1	0
OR2B6	26212	broad.mit.edu	37	6	27925349	27925349	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:27925349G>A	ENST00000244623.1	+	1	331	c.331G>A	c.(331-333)Gaa>Aaa	p.E111K		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGGGGCTACTGAATATCTTCT	0.453000													130	28					0	0	1	0	0
TTC37	9652	broad.mit.edu	37	5	94863760	94863760	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr5:94863760G>A	ENST00000358746.2	-	13	1389	c.1091C>T	c.(1090-1092)tCa>tTa	p.S364L		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	364							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						GTCATAATCTGAGAGTTTAAT	0.393000													6	77					0	0	1	0	0
GM2A	2760	broad.mit.edu	37	5	150646928	150646928	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr5:150646928G>A	ENST00000357164.3	+	4	823	c.498G>A	c.(496-498)ggG>ggA	p.G166G		NM_000405.4|NM_001167607.1	NP_000396.2|NP_001161079.1	P17900	SAP3_HUMAN	GM2 ganglioside activator	166						lysosome|nucleolus	sphingolipid activator protein activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|pancreas(1)|upper_aerodigestive_tract(2)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCACCACCGGGAACTACCGCA	0.582000													3	32					0	0	1	0	0
SAMD15	161394	broad.mit.edu	37	14	77844833	77844833	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr14:77844833C>T	ENST00000216471.4	+	1	1358	c.1072C>T	c.(1072-1074)Cca>Tca	p.P358S	SAMD15_ENST00000533095.2_Intron	NM_001010860.1	NP_001010860.1	Q9P1V8	SAM15_HUMAN	sterile alpha motif domain containing 15	358										breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						AATGATGAAACCAGAAAGTCC	0.403000													8	29					0	0	1	0	0
MLLT10	8028	broad.mit.edu	37	10	21823699	21823699	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:21823699C>T	ENST00000377072.3	+	2	474	c.126C>T	c.(124-126)tgC>tgT	p.C42C	MLLT10_ENST00000377091.2_Silent_p.C42C|MLLT10_ENST00000495130.1_3'UTR|MLLT10_ENST00000446906.2_Silent_p.C42C|MLLT10_ENST00000377100.3_Silent_p.C42C|MLLT10_ENST00000377059.3_Silent_p.C42C|MLLT10_ENST00000307729.7_Silent_p.C42C	NM_004641.3	NP_004632.1	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	42					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						TGGTTTATTGCGACGGGCACG	0.657000			T	"""MLL, PICALM, CDK6"""	AL								8	49					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8994153	8994153	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:8994153C>T	ENST00000397910.4	-	65	41735	c.41532G>A	c.(41530-41532)ctG>ctA	p.L13844L	MUC16_ENST00000380951.5_Silent_p.L485L	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13847	SEA 12.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAGCAAGGTCAGCCTGCAGC	0.532000													28	55					0	0	1	0	0
CDKN1A	1026	broad.mit.edu	37	6	36652129	36652129	+	Missense_Mutation	SNP	G	G	A	rs34916193	byFrequency	TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:36652129G>A	ENST00000405375.1	+	2	486	c.251G>A	c.(250-252)cGa>cAa	p.R84Q	CDKN1A_ENST00000448526.2_Missense_Mutation_p.R118Q|CDKN1A_ENST00000373711.2_Missense_Mutation_p.R84Q|CDKN1A_ENST00000244741.5_Missense_Mutation_p.R84Q|CDKN1A_ENST00000478800.1_3'UTR	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	84					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						GGGCCCCGGCGAGGCCGGGAT	0.652000													7	3					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120796685	120796685	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:120796685G>C	ENST00000369144.3	-	21	3992	c.3865C>G	c.(3865-3867)Cta>Gta	p.L1289V	EIF3A_ENST00000541549.1_Missense_Mutation_p.L1255V	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	1289	Asp-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TCGTCTCTTAGATCTCGTCTT	0.502000													60	68					0	0	1	0	0
KCTD18	130535	broad.mit.edu	37	2	201371692	201371692	+	Silent	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr2:201371692C>A	ENST00000359878.3	-	2	558	c.48G>T	c.(46-48)ctG>ctT	p.L16L	KCTD18_ENST00000468413.1_5'UTR|KCTD18_ENST00000409157.1_Silent_p.L16L	NM_152387.2	NP_689600.2	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain containing 18	16	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						CACCCACGTTCAGTCGGAGAA	0.507000													25	17					7.63505e-26	8.15902e-26	1	1	0
TRIM42	287015	broad.mit.edu	37	3	140397202	140397202	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:140397202A>G	ENST00000286349.3	+	1	322	c.131A>G	c.(130-132)tAc>tGc	p.Y44C		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	44	Cys-rich.					intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CCCTGCCCTTACAAAGATGAG	0.527000													19	146					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113553762	113553762	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:113553762C>G	ENST00000546530.1	-	10	1111	c.826G>C	c.(826-828)Gag>Cag	p.E276Q	RASAL1_ENST00000446861.3_Missense_Mutation_p.E276Q|RASAL1_ENST00000261729.5_Missense_Mutation_p.E276Q|RASAL1_ENST00000418411.2_5'UTR|RASAL1_ENST00000548055.1_Missense_Mutation_p.E276Q	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	276					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						TGCACAGACTCCATGAGCAGC	0.662000													44	59					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151155787	151155787	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:151155787C>G	ENST00000282466.3	-	6	6561	c.6562G>C	c.(6562-6564)Gat>Cat	p.D2188H	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2188	Ig-like C2-type 8.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTGTACCTATCAATGGAGAAG	0.463000													63	64					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47423813	47423813	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:47423813G>A	ENST00000404338.3	+	1	1881	c.1881G>A	c.(1879-1881)gtG>gtA	p.V627V		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	627					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										ACAAGTATGTGATAGATGGTA	0.458000													7	187					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166900334	166900334	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr2:166900334G>A	ENST00000423058.2	-	11	1905	c.1888C>T	c.(1888-1890)Cgg>Tgg	p.R630W	SCN1A_ENST00000303395.4_Missense_Mutation_p.R630W|AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.R630W|SCN1A_ENST00000409050.1_Missense_Mutation_p.R630W	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	630						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R630W(1)		NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GCCAGCATCCGGGATGACCTA	0.537000													33	20					0	0	1	0	0
CCRL2	9034	broad.mit.edu	37	3	46449682	46449682	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:46449682G>C	ENST00000399036.3	+	2	464	c.112G>C	c.(112-114)Gcc>Ccc	p.A38P	CCRL2_ENST00000357392.4_Missense_Mutation_p.A50P|CCRL2_ENST00000400880.3_Missense_Mutation_p.A38P|CCRL2_ENST00000400882.2_Missense_Mutation_p.A38P	NM_003965.4	NP_003956.2	O00421	CCRL2_HUMAN	chemokine (C-C motif) receptor-like 2						chemotaxis|inflammatory response	integral to plasma membrane	CCR chemokine receptor binding|chemokine receptor activity			lung(3)|ovary(1)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)		GGCACTCTCAGCCCAGCTGGT	0.507000													14	25					0	0	1	0	0
CAPN7	23473	broad.mit.edu	37	3	15258962	15258962	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:15258962C>A	ENST00000253693.2	+	3	495	c.242C>A	c.(241-243)tCa>tAa	p.S81*		NM_014296.2	NP_055111.1	Q9Y6W3	CAN7_HUMAN	calpain 7	81					proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|skin(2)	22						CCTTTGAAGTCAAAACATCAG	0.348000													28	28					2.85442e-18	2.99165e-18	1	1	0
TXNDC12	51060	broad.mit.edu	37	1	52489189	52489189	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:52489189T>C	ENST00000371626.4	-	6	1487	c.413A>G	c.(412-414)aAg>aGg	p.K138R	TXNDC12_ENST00000471493.1_5'UTR	NM_015913.3	NP_056997.1	O95831	AIFM1_HUMAN	thioredoxin domain containing 12 (endoplasmic reticulum)	209	FAD-dependent oxidoreductase (By similarity).				activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	7						ATAAAAATACTTGTAGCTGGG	0.413000													47	39					0	0	1	0	0
ZNF134	7693	broad.mit.edu	37	19	58132285	58132285	+	Silent	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:58132285G>C	ENST00000396161.5	+	3	1108	c.798G>C	c.(796-798)ggG>ggC	p.G266G		NM_003435.3	NP_003426.3	P52741	ZN134_HUMAN	zinc finger protein 134	266						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(3)|prostate(1)	11		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		ATGAATGTGGGAAATATTTTA	0.413000													17	132					0	0	1	0	0
HEATR4	399671	broad.mit.edu	37	14	73967376	73967376	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr14:73967376C>G	ENST00000553558.1	-	12	2485	c.2164G>C	c.(2164-2166)Gag>Cag	p.E722Q	HEATR4_ENST00000334988.2_Missense_Mutation_p.E722Q|HEATR4_ENST00000560393.1_Missense_Mutation_p.E675Q	NM_001220484.1	NP_001207413.1			HEAT repeat containing 4											breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		AGCTTGAGCTCACCTATCAGG	0.522000													16	60					0	0	1	0	0
DCAKD	79877	broad.mit.edu	37	17	43112181	43112181	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:43112181C>T	ENST00000452796.2	-	1	328	c.73G>A	c.(73-75)Ggc>Agc	p.G25S	DCAKD_ENST00000310604.4_Missense_Mutation_p.G25S|DCAKD_ENST00000588295.1_5'UTR|DCAKD_ENST00000588499.1_Missense_Mutation_p.G25S|DCAKD_ENST00000342350.5_Missense_Mutation_p.G25S			Q8WVC6	DCAKD_HUMAN	dephospho-CoA kinase domain containing	25	DPCK.				coenzyme A biosynthetic process		ATP binding|dephospho-CoA kinase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(2)|skin(1)	6		Prostate(33;0.155)				ACCGCACAGCCCAGCTGCTGG	0.632000													4	15					0	0	1	0	0
ATF7	11016	broad.mit.edu	37	12	53917062	53917062	+	Nonsense_Mutation	SNP	A	A	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:53917062A>C	ENST00000420353.2	-	11	1381	c.1232T>G	c.(1231-1233)tTa>tGa	p.L411*	ATF7_ENST00000546661.1_5'UTR|ATF7_ENST00000548446.2_Nonsense_Mutation_p.L422*|RP11-793H13.10_ENST00000591834.1_Nonsense_Mutation_p.L411*|ATF7_ENST00000415113.1_Nonsense_Mutation_p.L390*|ATF7_ENST00000456903.4_Nonsense_Mutation_p.L411*|ATF7_ENST00000328463.7_Nonsense_Mutation_p.L422*	NM_006856.2	NP_006847.1	P17544	ATF7_HUMAN	activating transcription factor 7	422	Essential for binding adenovirus 2 E1A.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)|urinary_tract(1)	9						CCACTCACCTAAATAGCCTTG	0.418000													23	29					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48463175	48463175	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:48463175C>G	ENST00000358536.4	-	7	1830	c.1561G>C	c.(1561-1563)Gag>Cag	p.E521Q	PLXNB1_ENST00000358459.4_Missense_Mutation_p.E521Q|PLXNB1_ENST00000296440.6_Missense_Mutation_p.E521Q|PLXNB1_ENST00000448774.2_Intron|PLXNB1_ENST00000456774.1_Missense_Mutation_p.E521Q	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	521					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGCCACTGCTCTGGGCCCTGG	0.607000													11	23					0	0	1	0	0
SUGP1	57794	broad.mit.edu	37	19	19416815	19416815	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:19416815G>A	ENST00000247001.5	-	4	728	c.381C>T	c.(379-381)ctC>ctT	p.L127L	SUGP1_ENST00000334782.5_Silent_p.L127L|SUGP1_ENST00000585763.1_5'UTR	NM_172231.3	NP_757386.2	Q8IWZ8	SUGP1_HUMAN	SURP and G patch domain containing 1	127					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	22						GCCTGCTGATGAGCAGGGACC	0.692000													12	21					0	0	1	0	0
HNRNPD	3184	broad.mit.edu	37	4	83280673	83280673	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:83280673G>C	ENST00000313899.7	-	3	687	c.410C>G	c.(409-411)tCa>tGa	p.S137*	HNRNPD_ENST00000541060.1_Intron|HNRNPD_ENST00000352301.4_Nonsense_Mutation_p.S118*|HNRNPD_ENST00000543098.1_Nonsense_Mutation_p.S85*|HNRNPD_ENST00000353341.4_Nonsense_Mutation_p.S137*	NM_031370.2	NP_112738.1	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	137	RRM 1.				nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	7						AAAACCCCTTGATCGCCCTGT	0.373000													93	22					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36103813	36103813	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr14:36103813C>T	ENST00000258840.6	-	33	4975	c.4585G>A	c.(4585-4587)Gaa>Aaa	p.E1529K	RALGAPA1_ENST00000382366.3_Missense_Mutation_p.E1495K|RALGAPA1_ENST00000307138.6_Missense_Mutation_p.E1482K|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.E1482K	NM_001283044.1	NP_001269973.1	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	1482	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GAAGATCGTTCTGAGTCAGGA	0.428000													14	54					0	0	1	0	0
SLC24A5	283652	broad.mit.edu	37	15	48414197	48414197	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr15:48414197G>C	ENST00000482911.2	+	2	306	c.265G>C	c.(265-267)Gaa>Caa	p.E89Q	SLC24A5_ENST00000341459.3_Missense_Mutation_p.E89Q|SLC24A5_ENST00000449382.2_Intron			Q71RS6	NCKX5_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 5	89					response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|skin(1)|upper_aerodigestive_tract(1)	27		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		TGTCTGTGATGAATACTTCCT	0.443000													67	72					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107845257	107845257	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:107845257C>T	ENST00000285311.3	-	4	1339	c.634G>A	c.(634-636)Gaa>Aaa	p.E212K	DKK2_ENST00000513208.1_Missense_Mutation_p.E112K|DKK2_ENST00000510463.1_Missense_Mutation_p.E166K	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	212	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GTACAGACTTCCCCCTGATGG	0.502000													13	135					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61868601	61868601	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:61868601C>T	ENST00000280772.2	-	27	3351	c.3160G>A	c.(3160-3162)Gca>Aca	p.A1054T	ANK3_ENST00000355288.2_Missense_Mutation_p.A188T|ANK3_ENST00000503366.1_Missense_Mutation_p.A1055T|ANK3_ENST00000373827.2_Missense_Mutation_p.A1048T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)		ZU5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AAAAATTGTGCCCCTGCAGGA	0.453000													4	45					0	0	1	0	0
FYN	2534	broad.mit.edu	37	6	112025302	112025302	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:112025302C>G	ENST00000354650.3	-	7	1053	c.447G>C	c.(445-447)tgG>tgC	p.W149C	FYN_ENST00000229471.4_Missense_Mutation_p.W149C|FYN_ENST00000368667.2_Missense_Mutation_p.W149C|FYN_ENST00000476769.2_5'UTR|FYN_ENST00000368678.4_Missense_Mutation_p.W149C|FYN_ENST00000229470.5_Missense_Mutation_p.W100C|FYN_ENST00000368682.3_Missense_Mutation_p.W149C|FYN_ENST00000538466.1_Missense_Mutation_p.W149C|FYN_ENST00000356013.2_Missense_Mutation_p.W149C	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	149	SH2.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TTCCAAAGTACCACCTTTAAA	0.398000													17	65					0	0	1	0	0
CDKN1A	1026	broad.mit.edu	37	6	36652140	36652140	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:36652140G>A	ENST00000405375.1	+	2	497	c.262G>A	c.(262-264)Gag>Aag	p.E88K	CDKN1A_ENST00000448526.2_Missense_Mutation_p.E122K|CDKN1A_ENST00000373711.2_Missense_Mutation_p.E88K|CDKN1A_ENST00000244741.5_Missense_Mutation_p.E88K|CDKN1A_ENST00000478800.1_3'UTR	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	88					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						AGGCCGGGATGAGTTGGGAGG	0.667000													9	0					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57598982	57598982	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:57598982A>G	ENST00000243077.3	+	73	11751	c.11285A>G	c.(11284-11286)aAc>aGc	p.N3762S		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3762	LDL-receptor class A 31.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTGCGCTGCAACATGTTCGAT	0.657000													15	97					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102505826	102505826	+	Silent	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr14:102505826G>C	ENST00000360184.4	+	61	11702	c.11538G>C	c.(11536-11538)ctG>ctC	p.L3846L	RP11-1017G21.4_ENST00000557551.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA|RP11-1017G21.4_ENST00000557242.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3846					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						ACCCGAACCTGAAGGGTGTCA	0.542000													24	21					0	0	1	0	0
CCR10	2826	broad.mit.edu	37	17	40831702	40831702	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:40831702C>T	ENST00000591765.1	-	2	1677	c.292G>A	c.(292-294)Gac>Aac	p.D98N	CCR10_ENST00000332438.4_Missense_Mutation_p.D320N			P46092	CCR10_HUMAN	chemokine (C-C motif) receptor 10	320						integral to plasma membrane				lung(1)|ovary(1)|skin(1)	3		Breast(137;0.000153)		BRCA - Breast invasive adenocarcinoma(366;0.14)		CTCCGCAGGTCCTGGCGGAAG	0.711000													9	12					0	0	1	0	0
RNF145	153830	broad.mit.edu	37	5	158586021	158586021	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr5:158586021G>A	ENST00000424310.2	-	11	2008	c.1649C>T	c.(1648-1650)aCg>aTg	p.T550M	RNF145_ENST00000518802.1_Missense_Mutation_p.T580M|RNF145_ENST00000274542.2_Missense_Mutation_p.T578M|RNF145_ENST00000520638.1_Missense_Mutation_p.T564M|RNF145_ENST00000519865.1_Missense_Mutation_p.T550M|RNF145_ENST00000521606.2_Missense_Mutation_p.T567M|RNF145_ENST00000518284.1_5'UTR	NM_001199383.1	NP_001186312.1	Q96MT1	RN145_HUMAN	ring finger protein 145	550						integral to membrane	zinc ion binding			endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTGCAAGGCGTGATCACAGC	0.448000													3	51					0	0	1	0	0
MARS	4141	broad.mit.edu	37	12	57882851	57882851	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:57882851G>A	ENST00000262027.5	+	2	293	c.159G>A	c.(157-159)ctG>ctA	p.L53L	MARS_ENST00000315473.5_5'UTR|MARS_ENST00000447721.2_Intron	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	53				L -> V (in Ref. 1; CAA64381).	methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	TCTTGCAGCTGGATAGCGGCA	0.473000													50	87					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193019073	193019073	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:193019073G>A	ENST00000342358.4	-	24	2819	c.2702C>T	c.(2701-2703)tCa>tTa	p.S901L	ATP13A5_ENST00000495496.1_5'UTR	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	901					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TCCAAAGGATGAAACCAGAGC	0.333000													5	231					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102505872	102505872	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr14:102505872G>C	ENST00000360184.4	+	61	11748	c.11584G>C	c.(11584-11586)Gac>Cac	p.D3862H	RP11-1017G21.4_ENST00000557551.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA|RP11-1017G21.4_ENST00000557242.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3862					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TATAACAAAGGACCTCTTCCA	0.547000													34	25					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78334906	78334906	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:78334906C>T	ENST00000397909.2	+	3	580	c.407C>T	c.(406-408)tCt>tTt	p.S136F	NAV3_ENST00000536525.2_Missense_Mutation_p.S136F|NAV3_ENST00000266692.7_Missense_Mutation_p.S136F|NAV3_ENST00000228327.6_Missense_Mutation_p.S136F			Q8IVL0	NAV3_HUMAN	neuron navigator 3	136	CH.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AGAAGTCAGTCTCAGATGGTA	0.294000										HNSCC(70;0.22)			11	102					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237494230	237494230	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:237494230C>G	ENST00000366574.2	+	3	538	c.221C>G	c.(220-222)tCt>tGt	p.S74C	RYR2_ENST00000542537.1_Missense_Mutation_p.S58C|RYR2_ENST00000360064.6_Missense_Mutation_p.L72V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	74					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAGTCCCTCTCTGTCCGGGCG	0.507000													22	52					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166690	19166690	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:19166690G>A	ENST00000375371.3	-	6	1944	c.1923C>T	c.(1921-1923)ttC>ttT	p.F641F		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	641					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TGCAGATTGTGAAGCAGAGGG	0.622000													21	69					0	0	1	0	0
ZNF212	7988	broad.mit.edu	37	7	148950974	148950974	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr7:148950974C>T	ENST00000335870.2	+	5	1084	c.956C>T	c.(955-957)tCt>tTt	p.S319F		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	319					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			TACGAATGTTCTGAGTGTGAG	0.577000													26	24					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25887280	25887280	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:25887280G>A	ENST00000376351.3	+	11	3084	c.2725G>A	c.(2725-2727)Gcc>Acc	p.A909T	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	909						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CATAGCAAGCGCCAAGGAGAA	0.478000													60	55					0	0	1	0	0
DRD4	1815	broad.mit.edu	37	11	639902	639902	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr11:639902G>A	ENST00000176183.5	+	3	665	c.653G>A	c.(652-654)gGc>gAc	p.G218D		NM_000797.3	NP_000788.2	P21917	DRD4_HUMAN	dopamine receptor D4	218					activation of MAPK activity|adult locomotory behavior|arachidonic acid secretion|behavioral fear response|behavioral response to cocaine|behavioral response to ethanol|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of protein secretion|positive regulation of sodium:hydrogen antiporter activity|regulation of dopamine metabolic process|regulation of inhibitory postsynaptic membrane potential|response to amphetamine|response to histamine|social behavior	integral to plasma membrane	dopamine D4 receptor activity|drug binding|potassium channel regulator activity|SH3 domain binding			NS(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.36e-28)|Epithelial(43;2.59e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Apomorphine(DB00714)|Clozapine(DB00363)|Olanzapine(DB00334)|Pramipexole(DB00413)|Promazine(DB00420)|Propiomazine(DB00777)|Ropinirole(DB00268)|Thiethylperazine(DB00372)|Ziprasidone(DB00246)	ACGTTCCGCGGCCTGCAGCGC	0.736000													5	14					0	0	1	0	0
CXorf61	203413	broad.mit.edu	37	X	115593127	115593127	+	Silent	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chrX:115593127C>G	ENST00000371894.4	-	2	269	c.123G>C	c.(121-123)gtG>gtC	p.V41V		NM_001017978.2	NP_001017978.1	Q5H943	KKLC1_HUMAN	chromosome X open reading frame 61	41						integral to membrane|plasma membrane				breast(1)|large_intestine(3)|lung(8)	12						AAGAGGGTCTCACTAGTGCAA	0.373000													52	7					0	0	1	0	0
H1FOO	132243	broad.mit.edu	37	3	129269620	129269620	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:129269620G>C	ENST00000324382.2	+	4	780	c.775G>C	c.(775-777)Gag>Cag	p.E259Q	H1FOO_ENST00000503977.1_Missense_Mutation_p.E120Q	NM_153833.1	NP_722575.1	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	259					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding			endometrium(1)|lung(4)|skin(1)	6						AACCAAAGCTGAGAGTAAGAG	0.542000													17	15					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20588554	20588554	+	RNA	SNP	C	C	G	rs112526901	by1000genomes	TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr15:20588554C>G	ENST00000428453.1	-	0	4196																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CCGTGGAAAGCGGTTGCAGAA	0.473000													4	21					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3067474	3067474	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr18:3067474G>A	ENST00000400569.3	-	38	5177	c.4844C>T	c.(4843-4845)tCa>tTa	p.S1615L	MYOM1_ENST00000261606.7_Missense_Mutation_p.S1519L|MYOM1_ENST00000356443.4_Missense_Mutation_p.S1615L			P52179	MYOM1_HUMAN	myomesin 1	1615	Ig-like C2-type 5.			SD -> QT (in Ref. 5; CAA48833).		striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GTGGTCGTCTGAGGCCAGGGC	0.592000													25	10					0	0	1	0	0
PLCXD1	55344	broad.mit.edu	37	X	205419	205419	+	Silent	SNP	G	G	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chrX:205419G>T	ENST00000381657.2	+	3	661	c.147G>T	c.(145-147)acG>acT	p.T49T	PLCXD1_ENST00000484611.2_3'UTR|PLCXD1_ENST00000399012.1_Silent_p.T49T|PLCXD1_ENST00000381663.3_Silent_p.T49T	NM_018390.3	NP_060860.1	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 1	49	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process		phospholipase C activity			endometrium(3)|large_intestine(1)|lung(7)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACACGATGACGTACTGCCTGA	0.627000													42	69					1.00953e-15	1.04302e-15	1	1	0
SRCAP	10847	broad.mit.edu	37	16	30748865	30748865	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr16:30748865C>T	ENST00000262518.4	+	34	7889	c.7504C>T	c.(7504-7506)Cct>Tct	p.P2502S	SRCAP_ENST00000395059.2_Missense_Mutation_p.P2440S|SRCAP_ENST00000344771.4_Missense_Mutation_p.P2344S	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2502	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			ctgcacccctcctcctgcctg	0.552000													15	15					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433035	55433035	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr11:55433035G>A	ENST00000314259.3	+	1	422	c.393G>A	c.(391-393)acG>acA	p.T131T		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	131					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T131T(2)		breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TGCACTACACGATCATCATGA	0.512000													59	16					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24909082	24909082	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:24909082G>A	ENST00000396432.2	-	9	2228	c.1742C>T	c.(1741-1743)tCg>tTg	p.S581L	ARHGAP21_ENST00000320481.6_Missense_Mutation_p.S368L	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	580					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TTTAAACTGCGACACAGATCC	0.398000													14	117					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													4	119					0	0	1	0	0
TBC1D23	55773	broad.mit.edu	37	3	100029351	100029351	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:100029351C>T	ENST00000394144.4	+	14	1525	c.1518C>T	c.(1516-1518)atC>atT	p.I506I	TBC1D23_ENST00000486274.1_3'UTR|TBC1D23_ENST00000475134.1_Silent_p.I369I|TBC1D23_ENST00000344949.5_Silent_p.I506I	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	506						intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						AAAAAGTTATCAGTTTTATAG	0.328000													19	34					0	0	1	0	0
LPCAT2	54947	broad.mit.edu	37	16	55616991	55616991	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr16:55616991C>G	ENST00000262134.5	+	14	1800	c.1616C>G	c.(1615-1617)tCa>tGa	p.S539*		NM_017839.4	NP_060309.2	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	539					cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	12						GAGAGTACCTCAGACAAAAAA	0.393000													20	50					0	0	1	0	0
TSHR	7253	broad.mit.edu	37	14	81422127	81422127	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr14:81422127G>A	ENST00000541158.2	+	2	425	c.103G>A	c.(103-105)Gag>Aag	p.E35K	TSHR_ENST00000554435.1_Missense_Mutation_p.E35K|TSHR_ENST00000557096.1_3'UTR|TSHR_ENST00000298171.2_Missense_Mutation_p.E35K|TSHR_ENST00000342443.6_Missense_Mutation_p.E35K|TSHR_ENST00000554263.1_Missense_Mutation_p.E35K			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	35					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	CCATCAGGAGGAGGACTTCAG	0.622000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						7	100					0	0	1	0	0
CSE1L	1434	broad.mit.edu	37	20	47711290	47711290	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr20:47711290G>C	ENST00000262982.2	+	24	2739	c.2616G>C	c.(2614-2616)ttG>ttC	p.L872F	CSE1L_ENST00000469700.1_3'UTR|CSE1L_ENST00000542325.1_Missense_Mutation_p.L655F|CSE1L_ENST00000396192.3_Missense_Mutation_p.L816F	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	872					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TACAGTCTTTGATTGGTCTTT	0.388000													9	73					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400191	40400191	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:40400191G>T	ENST00000338305.6	-	2	1204	c.662C>A	c.(661-663)tCc>tAc	p.S221Y		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	221						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					CGAAGCCTGGGAGCGGGCAAA	0.592000													5	33					1.23904e-05	1.24475e-05	1	1	0
LDLRAP1	26119	broad.mit.edu	37	1	25880540	25880540	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:25880540G>C	ENST00000374338.4	+	2	335	c.216G>C	c.(214-216)aaG>aaC	p.K72N	LDLRAP1_ENST00000488127.1_3'UTR	NM_015627.2	NP_056442.2	Q5SW96	ARH_HUMAN	low density lipoprotein receptor adaptor protein 1	72	PID.				amyloid precursor protein metabolic process|cholesterol homeostasis|cholesterol metabolic process|positive regulation of receptor-mediated endocytosis|receptor internalization|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|regulation of establishment of protein localization in plasma membrane|regulation of protein binding	basal plasma membrane|cytosol|early endosome|internal side of plasma membrane|neurofilament|recycling endosome	beta-amyloid binding|clathrin binding|low-density lipoprotein particle receptor binding|phosphatidylinositol-4,5-bisphosphate binding|phosphotyrosine binding|protein binding, bridging|protein complex binding|receptor signaling complex scaffold activity|signaling adaptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)|urinary_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.63e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|GBM - Glioblastoma multiforme(114;0.00914)|READ - Rectum adenocarcinoma(331;0.0649)		CCGCCATCAAGAGGATCGTGG	0.627000													18	27					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36270222	36270222	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:36270222G>C	ENST00000394571.2	+	6	1360	c.1360G>C	c.(1360-1362)Gaa>Caa	p.E454Q	PNPLA1_ENST00000312917.5_Missense_Mutation_p.E368Q|PNPLA1_ENST00000388715.3_Missense_Mutation_p.E359Q	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	454					lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						ACCTGTGGAGGAACTAGGCCA	0.587000											OREG0017382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	100					0	0	1	0	0
TAF6L	10629	broad.mit.edu	37	11	62554063	62554063	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr11:62554063G>A	ENST00000294168.3	+	11	1365	c.1164G>A	c.(1162-1164)ggG>ggA	p.G388G	RP11-727F15.12_ENST00000601484.1_RNA|TMEM223_ENST00000527073.1_Intron	NM_006473.3	NP_006464.1	Q9Y6J9	TAF6L_HUMAN	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	388					chromatin remodeling|histone H3 acetylation|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	histone deacetylase complex|STAGA complex	DNA binding|protein binding|transcription coactivator activity			endometrium(2)|large_intestine(5)|lung(4)|ovary(3)|prostate(1)|skin(1)	16						GTGGCAGGGGGTGCCGGCGCC	0.652000											OREG0021030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	5					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21220309	21220309	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:21220309G>A	ENST00000540229.1	+	14	1987	c.1922G>A	c.(1921-1923)cGa>cAa	p.R641Q	SLCO1B7_ENST00000541784.1_3'UTR|LST3_ENST00000381541.3_Missense_Mutation_p.R580Q|SLCO1B7_ENST00000554957.1_Missense_Mutation_p.R580Q|RP11-125O5.2_ENST00000590779.1_Missense_Mutation_p.D34N|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.R533Q|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.R641Q																							ATGATTATGCGATCGCTAGGT	0.284000													6	8					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35862172	35862172	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:35862172C>T	ENST00000314607.6	+	19	3011	c.2931C>T	c.(2929-2931)ccC>ccT	p.P977P	ZMYM4_ENST00000373297.2_Silent_p.P888P	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	977					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAAGTCAGCCCCAGATTATTG	0.388000													68	91					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73065807	73065807	+	RNA	SNP	A	A	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chrX:73065807A>T	ENST00000429829.1	-	0	6781					NR_001564.2																						TTCAGATGGAATGGGCAAAGT	0.473000													58	13					0	0	1	0	0
INO80	54617	broad.mit.edu	37	15	41313305	41313305	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr15:41313305C>A	ENST00000361937.3	-	26	3491	c.3067G>T	c.(3067-3069)Gat>Tat	p.D1023Y	INO80_ENST00000401393.3_Missense_Mutation_p.D1023Y|RP11-540O11.4_ENST00000558967.1_RNA			Q9ULG1	INO80_HUMAN	INO80 complex subunit	1023	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						CAGTAAGAATCCAATGGCACT	0.473000													20	29					1.87028e-06	1.8876e-06	1	1	0
NKIRAS2	28511	broad.mit.edu	37	17	40174451	40174451	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:40174451C>T	ENST00000307641.5	+	3	750	c.129C>T	c.(127-129)taC>taT	p.Y43Y	NKIRAS2_ENST00000462043.2_Intron|NKIRAS2_ENST00000449471.4_Silent_p.Y43Y|NKIRAS2_ENST00000479407.1_Silent_p.Y43Y|NKIRAS2_ENST00000393884.2_Silent_p.Y41Y|NKIRAS2_ENST00000316082.4_Silent_p.Y43Y|NKIRAS2_ENST00000393880.1_Silent_p.Y43Y|NKIRAS2_ENST00000393881.3_Silent_p.Y43Y|NKIRAS2_ENST00000393885.4_Silent_p.Y43Y	NM_001001349.2	NP_001001349.1	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2	43	Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	9		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)				AGGACATCTACGTGGGCTCCA	0.552000													12	32					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70990556	70990556	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr14:70990556T>C	ENST00000256389.3	-	2	1313	c.1069A>G	c.(1069-1071)Aag>Gag	p.K357E	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	307	Peptidase M12B.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		ACACCAAGCTTCATGCCTTGT	0.333000													21	73					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113357287	113357287	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:113357287C>T	ENST00000202917.5	+	6	1395	c.1132C>T	c.(1132-1134)Cat>Tat	p.H378Y	RP1-71H24.1_ENST00000552784.1_RNA|OAS1_ENST00000445409.2_Intron|OAS1_ENST00000551241.1_Intron	NM_016816.2	NP_058132.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	378					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						TCATTTCTCTCATAGACCCAG	0.527000													27	33					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72991733	72991733	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr16:72991733C>A	ENST00000268489.5	-	2	2984	c.2312G>T	c.(2311-2313)gGg>gTg	p.G771V	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	771	Poly-Ala.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccCCGGCAGTGTG	0.622000													34	65					3.21399e-22	3.38479e-22	1	1	0
FFAR3	2865	broad.mit.edu	37	19	35849962	35849962	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:35849962T>C	ENST00000327809.4	+	2	371	c.170T>C	c.(169-171)cTg>cCg	p.L57P	FFAR3_ENST00000594310.1_Missense_Mutation_p.L57P	NM_005304.3	NP_005295.1	O14843	FFAR3_HUMAN	free fatty acid receptor 3	57						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|stomach(1)	17	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CTGCTCAACCTGACCGCCTCG	0.667000													9	94					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2810398	2810398	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr16:2810398C>T	ENST00000301740.8	+	10	1479	c.930C>T	c.(928-930)ttC>ttT	p.F310F		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	310	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						ATGCGCCTTTCAGTGAACCAG	0.552000													15	21					0	0	1	0	0
POLG2	11232	broad.mit.edu	37	17	62492646	62492646	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:62492646T>A	ENST00000539111.2	-	1	508	c.441A>T	c.(439-441)ttA>ttT	p.L147F		NM_007215.3	NP_009146.2	Q9UHN1	DPOG2_HUMAN	polymerase (DNA directed), gamma 2, accessory subunit	147					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(4)|skin(2)|stomach(1)|urinary_tract(1)	15	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			CTGCAGAAACTAACCTGAAGG	0.512000													26	96					0	0	1	0	0
C1orf186	440712	broad.mit.edu	37	1	206241569	206241569	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:206241569C>T	ENST00000331555.5	-	4	858	c.220G>A	c.(220-222)Gag>Aag	p.E74K		NM_001007544.1	NP_001007545.1	Q6ZWK4	CA186_HUMAN	chromosome 1 open reading frame 186	74						integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	9			BRCA - Breast invasive adenocarcinoma(75;0.0754)			ATGTCTCTCTCTGTCTGAGTC	0.537000													58	104					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38816347	38816347	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr7:38816347T>C	ENST00000310301.4	-	11	868	c.814A>G	c.(814-816)Agt>Ggt	p.S272G	VPS41_ENST00000466017.1_5'UTR|VPS41_ENST00000395969.2_Missense_Mutation_p.S247G	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	272					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						GCAAGTCCACTGATGTAGAAT	0.418000													23	14					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39229853	39229853	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:39229853C>G	ENST00000340369.3	-	2	1312	c.1084G>C	c.(1084-1086)Gag>Cag	p.E362Q	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.E362Q	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	362							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GCTCCAGCCTCTTCGTCCCCC	0.582000													61	115					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	123983535	123983535	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:123983535G>C	ENST00000360013.3	+	4	575	c.448G>C	c.(448-450)Gag>Cag	p.E150Q	KALRN_ENST00000240874.3_Missense_Mutation_p.E150Q|KALRN_ENST00000460856.1_Missense_Mutation_p.E150Q	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	150	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						ATTCATCTTTGAGGTGAGCCA	0.468000													21	29					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													12	13					0	0	1	0	0
CDKN1A	1026	broad.mit.edu	37	6	36652024	36652024	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:36652024G>A	ENST00000405375.1	+	2	381	c.146G>A	c.(145-147)tGg>tAg	p.W49*	CDKN1A_ENST00000448526.2_Nonsense_Mutation_p.W83*|CDKN1A_ENST00000373711.2_Nonsense_Mutation_p.W49*|CDKN1A_ENST00000244741.5_Nonsense_Mutation_p.W49*|CDKN1A_ENST00000478800.1_3'UTR	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	49					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding	p.W49*(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						CGTGAGCGATGGAACTTCGAC	0.667000													25	8					0	0	1	0	0
C5orf49	134121	broad.mit.edu	37	5	7835608	7835608	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr5:7835608C>T	ENST00000399810.2	-	2	619	c.151G>A	c.(151-153)Gga>Aga	p.G51R	C5orf49_ENST00000509627.1_Missense_Mutation_p.G51R	NM_001089584.2	NP_001083053.1	A4QMS7	CE049_HUMAN	chromosome 5 open reading frame 49	51										large_intestine(3)|lung(5)|skin(1)	9						GAAATAATTCCTGTCTAGGAA	0.448000													45	41					0	0	1	0	0
HPS3	84343	broad.mit.edu	37	3	148880481	148880481	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:148880481T>G	ENST00000296051.2	+	13	2437	c.2297T>G	c.(2296-2298)cTt>cGt	p.L766R	HPS3_ENST00000460120.1_Missense_Mutation_p.L601R	NM_032383.3	NP_115759.2	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3	766						cytoplasm				breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	34			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TTTAAGGTGCTTTGTGCTAAG	0.443000									Hermansky-Pudlak syndrome				33	54					0	0	1	0	0
ZNF546	339327	broad.mit.edu	37	19	40520587	40520587	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:40520587A>T	ENST00000347077.4	+	7	1626	c.1410A>T	c.(1408-1410)gaA>gaT	p.E470D	ZNF546_ENST00000600094.1_Missense_Mutation_p.E444D|ZNF546_ENST00000596894.1_Intron	NM_178544.3	NP_848639.2	Q86UE3	ZN546_HUMAN	zinc finger protein 546	470					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(15)|lung(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	34	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AACCCTATGAATGTAAGGAAT	0.408000													9	125					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32656088	32656088	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr2:32656088C>G	ENST00000421745.2	+	12	3312	c.3178C>G	c.(3178-3180)Caa>Gaa	p.Q1060E		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	1060					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GAGGCATCCTCAACATTTGCA	0.448000													16	21					0	0	1	0	0
EIF3I	8668	broad.mit.edu	37	1	32691917	32691917	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:32691917G>C	ENST00000373586.1	+	5	468	c.396G>C	c.(394-396)caG>caC	p.Q132H	EIF3I_ENST00000471486.1_3'UTR	NM_003757.2	NP_003748.1	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3, subunit I	132						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				ATCCGAGCCAGATTGGTGAGG	0.542000													45	41					0	0	1	0	0
IBSP	3381	broad.mit.edu	37	4	88731758	88731758	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:88731758G>C	ENST00000226284.5	+	6	314	c.247G>C	c.(247-249)Gag>Cag	p.E83Q		NM_004967.3	NP_004958.2	P21815	SIAL_HUMAN	integrin-binding sialoprotein	83	Asp/Glu-rich (acidic).|Poly-Glu.				biomineral tissue development|cell adhesion|ossification					breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)	21		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		TTTTTAACAGGAGACTTCAAA	0.338000													12	67					0	0	1	0	0
RFC2	5982	broad.mit.edu	37	7	73663415	73663415	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr7:73663415G>C	ENST00000055077.3	-	4	319	c.259C>G	c.(259-261)Ctg>Gtg	p.L87V	RFC2_ENST00000352131.3_Missense_Mutation_p.L87V	NM_181471.1	NP_852136.1	P35250	RFC2_HUMAN	replication factor C (activator 1) 2, 40kDa	87					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(3)	8						GCCAAGCACAGAATGCTTGTG	0.532000													15	56					0	0	1	0	0
WDR74	54663	broad.mit.edu	37	11	62603002	62603002	+	Silent	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr11:62603002C>A	ENST00000525239.1	-	7	1056	c.519G>T	c.(517-519)gtG>gtT	p.V173V	WDR74_ENST00000540620.1_5'UTR|WDR74_ENST00000525752.1_Silent_p.V116V|WDR74_ENST00000278856.4_Silent_p.V173V|WDR74_ENST00000311713.7_Silent_p.V173V|WDR74_ENST00000529106.1_Silent_p.V173V			Q6RFH5	WDR74_HUMAN	WD repeat domain 74	173						nucleolus				kidney(2)|large_intestine(1)|liver(1)|lung(3)|ovary(1)	8						AGTCATTCCGCACCTGGTGGG	0.587000													28	13					2.14196e-07	2.18199e-07	1	1	0
WNK3	65267	broad.mit.edu	37	X	54264805	54264805	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chrX:54264805C>G	ENST00000354646.2	-	19	4422	c.3984G>C	c.(3982-3984)atG>atC	p.M1328I	WNK3_ENST00000375159.2_Missense_Mutation_p.M1328I|WNK3_ENST00000375169.3_Missense_Mutation_p.M1281I	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1281			T -> I (in dbSNP:rs55879434).		intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						ATGATCCACTCATCGCTTTAC	0.443000													41	9					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966385	41966385	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:41966385T>C	ENST00000298919.7	+	10	1412	c.1024T>C	c.(1024-1026)Tac>Cac	p.Y342H	PDZRN4_ENST00000539469.2_Missense_Mutation_p.Y344H|PDZRN4_ENST00000402685.2_Missense_Mutation_p.Y602H			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	602							ubiquitin-protein ligase activity|zinc ion binding	p.Y344H(1)		breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TGAACTTCAGTACAATGAGAG	0.498000													20	32					0	0	1	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215934	20215934	+	Silent	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr14:20215934G>A	ENST00000331723.1	+	1	348	c.348G>A	c.(346-348)ctG>ctA	p.L116L		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTTTTTGCTGACAGTCATGG	0.498000													36	34					0	0	1	0	0
C3P1	388503	broad.mit.edu	37	19	10169561	10169561	+	RNA	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:10169561G>A	ENST00000495140.1	+	0	1961																				endometrium(4)|large_intestine(2)|lung(6)|urinary_tract(1)	13						AACCTTTGCCGTAGCCATAGC	0.572000													5	80					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9264799	9264799	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:9264799G>A	ENST00000318602.7	-	4	746	c.439C>T	c.(439-441)Cgt>Tgt	p.R147C		NM_000014.4	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin	147					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	GAGACAACACGAAATTTCACT	0.393000													4	38					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149481978	149481978	+	RNA	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr7:149481978C>T	ENST00000378016.2	+	0	2766							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGGGGCATTCTGCCCCAGGG	0.612000													19	61					0	0	1	0	0
HTR1F	3355	broad.mit.edu	37	3	88040024	88040024	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:88040024C>G	ENST00000319595.4	+	1	179	c.125C>G	c.(124-126)tCc>tGc	p.S42C		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	42					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	ACTATCAACTCCCTTGTGATC	0.458000													74	83					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207890999	207890999	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:207890999C>T	ENST00000508064.2	+	11	1665	c.1605C>T	c.(1603-1605)agC>agT	p.S535S		NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	535	Sushi 8.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						GGGTTTGGAGCAGCCCTGCCC	0.527000													18	104					0	0	1	0	0
TRAF7	84231	broad.mit.edu	37	16	2222352	2222352	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr16:2222352C>T	ENST00000326181.6	+	8	768	c.636C>T	c.(634-636)ttC>ttT	p.F212F		NM_032271.2	NP_115647.2	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7, E3 ubiquitin protein ligase	212					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	23						GGTGCCCCTTCACCATCAAGC	0.687000													7	26					0	0	1	0	0
FAM160B2	64760	broad.mit.edu	37	8	21960404	21960404	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr8:21960404C>G	ENST00000289921.7	+	17	2240	c.2194C>G	c.(2194-2196)Cgc>Ggc	p.R732G		NM_022749.5	NP_073586.5	Q86V87	F16B2_HUMAN	family with sequence similarity 160, member B2	732										endometrium(2)|kidney(1)|lung(2)|prostate(3)|urinary_tract(1)	9						ACATGATCCTCGCCAGAACGT	0.652000													10	31					0	0	1	0	0
C2orf42	54980	broad.mit.edu	37	2	70392315	70392315	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr2:70392315C>T	ENST00000264434.2	-	8	1641	c.1262G>A	c.(1261-1263)cGg>cAg	p.R421Q	C2orf42_ENST00000420306.1_Missense_Mutation_p.R421Q	NM_017880.1	NP_060350.1	Q9NWW7	CB042_HUMAN	chromosome 2 open reading frame 42	421										endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	12						GGCATCTTTCCGAACAAAAGC	0.338000													6	88					0	0	1	0	0
CBX4	8535	broad.mit.edu	37	17	77807809	77807809	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:77807809G>C	ENST00000269397.4	-	5	1809	c.1632C>G	c.(1630-1632)gaC>gaG	p.D544E		NM_003655.2	NP_003646.2	O00257	CBX4_HUMAN	chromobox homolog 4	544	Interaction with RNF2.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TCGCGGTGACGTCGGTGATAA	0.627000													12	70					0	0	1	0	0
TNFSF10	8743	broad.mit.edu	37	3	172241168	172241168	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:172241168T>C	ENST00000241261.2	-	1	129	c.7A>G	c.(7-9)Atg>Gtg	p.M3V	TNFSF10_ENST00000420541.2_Missense_Mutation_p.M3V	NM_003810.3	NP_003801.1	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily, member 10	3					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			breast(2)|cervix(1)|large_intestine(1)|lung(6)|ovary(1)|skin(4)	15	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			ACCTCCATCATAGCCATGATC	0.527000													17	35					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145296403	145296403	+	Silent	SNP	C	C	T	rs4996269	by1000genomes	TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:145296403C>T	ENST00000342960.5	+	3	360	c.325C>T	c.(325-327)Cta>Tta	p.L109L	NBPF10_ENST00000369338.1_Intron|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369339.3_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	109										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCTGACCCAGCTAAGGGAGAA	0.517000													6	459					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32726670	32726670	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:32726670T>G	ENST00000435145.2	-	3	664	c.603A>C	c.(601-603)caA>caC	p.Q201H	HLA-DQB2_ENST00000411527.1_Missense_Mutation_p.Q201H|HLA-DQB2_ENST00000437316.2_Missense_Mutation_p.Q201H			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	201					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex		p.Q201H(1)		endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						GGTGCTCCACTTGGCAGGTGT	0.557000													5	114					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088903	86088903	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr14:86088903G>T	ENST00000330753.4	+	2	1812	c.1045G>T	c.(1045-1047)Gcc>Tcc	p.A349S	FLRT2_ENST00000554746.1_Missense_Mutation_p.A349S	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	349	LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CCGGGGGATGGCCGTCAGGGA	0.527000													93	63					4.21773e-46	4.57446e-46	1	1	0
NAA11	84779	broad.mit.edu	37	4	80246861	80246861	+	Silent	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:80246861C>A	ENST00000286794.4	-	1	343	c.171G>T	c.(169-171)ctG>ctT	p.L57L		NM_032693.2	NP_116082.1	Q9BSU3	NAA11_HUMAN	N(alpha)-acetyltransferase 11, NatA catalytic subunit	57	Interaction with NAA15 (By similarity).|N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|skin(2)	23						CCATTTTGGCCAGAACATAGC	0.532000													23	145					3.6726e-16	3.81251e-16	1	1	0
FBF1	85302	broad.mit.edu	37	17	73906805	73906805	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:73906805C>T	ENST00000586717.1	-	29	3674	c.3401G>A	c.(3400-3402)tGa>tAa	p.*1134*	FBF1_ENST00000389570.4_Silent_p.*1135*|FBF1_ENST00000319129.5_Silent_p.*1134*|RP11-552F3.12_ENST00000587556.1_Intron			A6NLR5	A6NLR5_HUMAN	Fas (TNFRSF6) binding factor 1	0										large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	4						GGGTCCCACTCAGGCTGAATG	0.557000													5	4					0	0	1	0	0
GML	2765	broad.mit.edu	37	8	143922583	143922583	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr8:143922583C>T	ENST00000220940.1	+	3	213	c.123C>T	c.(121-123)aaC>aaT	p.N41N		NM_002066.2	NP_002057.1	Q99445	GML_HUMAN	glycosylphosphatidylinositol anchored molecule like	41	UPAR/Ly6.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation	anchored to membrane|extrinsic to membrane|plasma membrane				NS(1)|central_nervous_system(2)|endometrium(1)|large_intestine(6)|lung(8)	18	all_cancers(97;4.26e-11)|all_epithelial(106;1.85e-08)|Lung NSC(106;0.000274)|all_lung(105;0.000755)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					ATGACTTCAACTGTCCCAACA	0.448000													23	142					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32726684	32726684	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:32726684T>C	ENST00000435145.2	-	3	650	c.589A>G	c.(589-591)Atc>Gtc	p.I197V	HLA-DQB2_ENST00000411527.1_Missense_Mutation_p.I197V|HLA-DQB2_ENST00000437316.2_Missense_Mutation_p.I197V			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	197					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						CAGGTGTAGATGTCTCCACGC	0.567000													5	125					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111019793	111019793	+	Silent	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chrX:111019793T>C	ENST00000262839.2	-	11	3588	c.2670A>G	c.(2668-2670)aaA>aaG	p.K890K		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	890					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AGGCCTCTGCTTTCCCTTTCT	0.473000													43	7					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33515162	33515162	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:33515162G>A	ENST00000265371.4	-	8	1562	c.1037C>T	c.(1036-1038)tCa>tTa	p.S346L	NRP1_ENST00000374875.1_Missense_Mutation_p.S165L|NRP1_ENST00000395995.1_Missense_Mutation_p.S346L|NRP1_ENST00000374816.3_Missense_Mutation_p.S346L|NRP1_ENST00000374867.2_Missense_Mutation_p.S346L|NRP1_ENST00000374822.4_Missense_Mutation_p.S346L|NRP1_ENST00000374821.5_Missense_Mutation_p.S346L|NRP1_ENST00000374823.5_Missense_Mutation_p.S346L|NRP1_ENST00000432372.2_Missense_Mutation_p.S346L			O14786	NRP1_HUMAN	neuropilin 1	346	F5/8 type C 1.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	GGTTTCTTTTGAAATGGCGCC	0.483000													45	29					0	0	1	0	0
SEMA4A	64218	broad.mit.edu	37	1	156131157	156131157	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:156131157G>T	ENST00000368285.3	+	9	1098	c.831G>T	c.(829-831)aaG>aaT	p.K277N	SEMA4A_ENST00000368286.2_Missense_Mutation_p.K145N|SEMA4A_ENST00000368282.1_Missense_Mutation_p.K277N|SEMA4A_ENST00000368284.1_Missense_Mutation_p.K145N|SEMA4A_ENST00000487358.1_3'UTR|SEMA4A_ENST00000355014.2_Missense_Mutation_p.K277N	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	277	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					GCGGCGAAAAGCTGCTGCAGA	0.726000													26	24					5.61819e-17	5.86012e-17	1	1	0
ANK2	287	broad.mit.edu	37	4	114274578	114274578	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:114274578G>C	ENST00000357077.4	+	38	4857	c.4804G>C	c.(4804-4806)Gag>Cag	p.E1602Q	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.E1569Q	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1569					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GGAAATAGAAGAGGCTAGGCA	0.408000													54	12					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47969053	47969053	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:47969053G>C	ENST00000236877.6	-	2	1003	c.608C>G	c.(607-609)tCt>tGt	p.S203C	SLC8A2_ENST00000542837.1_Intron|SLC8A2_ENST00000539381.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	203					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		GATGCTCCAAGAGGCAGTGAC	0.527000													15	21					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43307619	43307619	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:43307619G>C	ENST00000361428.2	-	10	4194	c.4117C>G	c.(4117-4119)Ctt>Gtt	p.L1373V	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1373					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			AAGGTGTTAAGAGGAGCTGGC	0.478000													8	40					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:1803568C>G	ENST00000340107.4	+	7	1002	c.746C>G	c.(745-747)tCc>tGc	p.S249C	FGFR3_ENST00000412135.2_Missense_Mutation_p.S249C|FGFR3_ENST00000440486.2_Missense_Mutation_p.S249C|FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000260795.2_Missense_Mutation_p.S249C|FGFR3_ENST00000481110.2_Missense_Mutation_p.S249C|FGFR3_ENST00000352904.1_Missense_Mutation_p.S249C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	249			S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1204)|p.R248_S249del(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.736000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				17	2					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77328940	77328940	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr16:77328940C>T	ENST00000282849.5	-	19	3304	c.2886G>A	c.(2884-2886)aaG>aaA	p.K962K		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	962	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTTGGAAGGGCTTCTTTTGCA	0.542000													34	45					0	0	1	0	0
RIMS3	9783	broad.mit.edu	37	1	41107541	41107541	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:41107541C>T	ENST00000372684.3	-	3	526	c.57G>A	c.(55-57)cgG>cgA	p.R19R	RIMS3_ENST00000372683.1_Silent_p.R19R	NM_014747.2	NP_055562.2	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	19					neurotransmitter transport	cell junction|synapse				NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			TGCTGGAGCTCCGCACCACAT	0.662000													15	40					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54544282	54544282	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:54544282G>C	ENST00000338372.2	-	9	819	c.644C>G	c.(643-645)tCt>tGt	p.S215C	VSTM1_ENST00000376626.1_Missense_Mutation_p.S184C|VSTM1_ENST00000425006.2_3'UTR|VSTM1_ENST00000366170.2_Missense_Mutation_p.S127C	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	215						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		AGCTGCCTCAGACAGGGCGCT	0.527000													24	32					0	0	1	0	0
MROH7-TTC4	100527960	broad.mit.edu	37	1	55172134	55172134	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:55172134C>T	ENST00000414150.2	+	22	3869	c.3591C>T	c.(3589-3591)ttC>ttT	p.F1197F	MROH7_ENST00000409996.1_Silent_p.F765F|MROH7_ENST00000454855.2_Silent_p.F715F|MROH7_ENST00000421030.2_Silent_p.F1197F																							ACAGCGCCTTCATATTCCTCA	0.532000													7	106					0	0	1	0	0
TAP1	6890	broad.mit.edu	37	6	32821421	32821421	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:32821421C>G	ENST00000354258.4	-	1	334	c.173G>C	c.(172-174)cGa>cCa	p.R58P	PSMB9_ENST00000395330.1_Intron	NM_000593.5	NP_000584.2	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	58					antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(4)|prostate(1)|skin(1)	21						CATTGGCACTCGGACGCCGTC	0.726000													22	2					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128481540	128481540	+	Silent	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr7:128481540C>A	ENST00000325888.8	+	13	2301	c.2040C>A	c.(2038-2040)acC>acA	p.T680T	FLNC_ENST00000346177.6_Silent_p.T680T	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	680					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TGGAGCCTACCGGCTGCATCG	0.627000													43	125					2.43468e-25	2.58907e-25	1	1	0
TKTL2	84076	broad.mit.edu	37	4	164394267	164394267	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:164394267C>A	ENST00000280605.3	-	1	780	c.620G>T	c.(619-621)tGt>tTt	p.C207F		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	207						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AAAGGCTTCACAGCAATTCTG	0.507000													82	17					1.24819e-59	1.36736e-59	1	1	0
PTCRA	171558	broad.mit.edu	37	6	42890772	42890772	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:42890772C>T	ENST00000304672.1	+	2	147	c.66C>T	c.(64-66)ggC>ggT	p.G22G	PTCRA_ENST00000441198.1_Intron|PTCRA_ENST00000446507.1_Intron	NM_001243168.1|NM_138296.2	NP_001230097.1|NP_612153.2	Q6ISU1	PTCRA_HUMAN	pre T-cell antigen receptor alpha	22						integral to membrane	receptor activity			large_intestine(2)|lung(4)|ovary(2)	8	Colorectal(47;0.196)		all cancers(41;0.000731)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CAGGTGTGGGCGGCACACCCT	0.562000													7	25					0	0	1	0	0
ZNF496	84838	broad.mit.edu	37	1	247492647	247492647	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr1:247492647C>T	ENST00000294753.4	-	3	698	c.234G>A	c.(232-234)aaG>aaA	p.K78K	ZNF496_ENST00000366498.2_Silent_p.K78K	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	78	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			GAATCTGCTCCTTGGTGTGCC	0.711000													26	25					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120935617	120935617	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr7:120935617C>T	ENST00000310396.5	+	23	3459	c.2992C>T	c.(2992-2994)Cga>Tga	p.R998*		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		AACAAATTTTCGATCGCCATA	0.358000													23	56					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54142044	54142044	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr8:54142044C>A	ENST00000265572.3	-	4	1253	c.956G>T	c.(955-957)gGc>gTc	p.G319V	OPRK1_ENST00000524278.1_Missense_Mutation_p.G230V|RP11-162D9.3_ENST00000524425.1_RNA|OPRK1_ENST00000520287.1_Missense_Mutation_p.G319V	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	319					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	GTTGGTATAGCCTAAGGCGAT	0.507000													14	18					1.5842e-08	1.62139e-08	1	1	0
CLINT1	9685	broad.mit.edu	37	5	157232957	157232957	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr5:157232957G>C	ENST00000523094.1	-	7	1010	c.805C>G	c.(805-807)Ctt>Gtt	p.L269V	CLINT1_ENST00000411809.2_Missense_Mutation_p.L287V|CLINT1_ENST00000530742.1_Missense_Mutation_p.L269V|CLINT1_ENST00000296951.5_Missense_Mutation_p.L269V|CLINT1_ENST00000523908.1_Missense_Mutation_p.L287V	NM_001195555.1|NM_001195556.1	NP_001182484.1|NP_001182485.1	Q14677	EPN4_HUMAN	clathrin interactor 1	287					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|urinary_tract(1)	21	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCTGCTCCAAGATCAATGGTT	0.483000													3	57					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22155637	22155637	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr16:22155637C>T	ENST00000389398.5	+	26	2758	c.2662C>T	c.(2662-2664)Cat>Tat	p.H888Y	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	888						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		CAACTGCACTCATCAAAAGTC	0.418000													13	17					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29994127	29994127	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr16:29994127C>T	ENST00000308893.4	+	11	1947	c.904C>T	c.(904-906)Cgg>Tgg	p.R302W	TAOK2_ENST00000543033.1_Missense_Mutation_p.R302W|TAOK2_ENST00000416441.2_Missense_Mutation_p.R129W|TAOK2_ENST00000279394.3_Missense_Mutation_p.R302W	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	302					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						GGATGCCGTGCGGGAGCTGGA	0.622000													7	41					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48581003	48581003	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:48581003G>C	ENST00000537810.1	-	23	3119	c.2515C>G	c.(2515-2517)Cag>Gag	p.Q839E	FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000507711.1_Missense_Mutation_p.Q839E|FRYL_ENST00000503238.1_Missense_Mutation_p.Q839E|FRYL_ENST00000358350.4_Missense_Mutation_p.Q839E			O94915	FRYL_HUMAN	FRY-like	839					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						ATATCGACCTGAGGGGACAAC	0.328000													5	126					0	0	1	0	0
ANKS3	124401	broad.mit.edu	37	16	4747338	4747338	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr16:4747338C>G	ENST00000304283.4	-	16	2184	c.1890G>C	c.(1888-1890)gaG>gaC	p.E630D	ANKS3_ENST00000446014.2_Missense_Mutation_p.E501D|ANKS3_ENST00000585773.1_Missense_Mutation_p.E557D	NM_133450.3	NP_597707.1	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain containing 3	630										endometrium(5)|kidney(4)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	19						ACTCACCCATCTCACGGACAC	0.632000													11	51					0	0	1	0	0
SH2B3	10019	broad.mit.edu	37	12	111855990	111855990	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:111855990C>T	ENST00000341259.2	+	2	398	c.41C>T	c.(40-42)gCg>gTg	p.A14V		NM_005475.2	NP_005466.1	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	14					blood coagulation	cytosol	signal transducer activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	10						CCCTCTTCCGCGCCCTCAGCC	0.741000													11	13					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46279860	46279860	+	Silent	SNP	G	G	A	rs151060280	byFrequency	TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr20:46279860G>A	ENST00000372004.3	+	20	3990	c.3774G>A	c.(3772-3774)caG>caA	p.Q1258Q	NCOA3_ENST00000371997.3_Silent_p.Q1253Q|NCOA3_ENST00000341724.6_Silent_p.Q1188Q|NCOA3_ENST00000371998.3_Silent_p.Q1262Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1262	Acetyltransferase.|Poly-Gln.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding	p.Q1262Q(1)		breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcagcaacagc	0.567000													3	55					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121448182	121448182	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr3:121448182C>T	ENST00000393667.3	-	4	365	c.255G>A	c.(253-255)gaG>gaA	p.E85E	GOLGB1_ENST00000472829.1_5'UTR|GOLGB1_ENST00000340645.5_Silent_p.E85E	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	85					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		CAGCTTTTCTCTCTTCCTGCC	0.294000													46	62					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35620623	35620623	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:35620623T>C	ENST00000353139.5	-	11	1775	c.1294A>G	c.(1294-1296)Att>Gtt	p.I432V	ACACA_ENST00000360679.3_Missense_Mutation_p.I337V|ACACA_ENST00000335166.5_Missense_Mutation_p.I317V|ACACA_ENST00000394406.2_Missense_Mutation_p.I395V	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	395	ATP-grasp.|Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GGAGTAGCAATAGTAGCAGGT	0.373000													22	277					0	0	1	0	0
KRT19	3880	broad.mit.edu	37	17	39680424	39680424	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:39680424C>G	ENST00000361566.3	-	5	979	c.919G>C	c.(919-921)Gag>Cag	p.E307Q		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				AGCTCAATCTCAAGACCCTGA	0.597000													20	21					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73488676	73488676	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:73488676C>G	ENST00000314256.7	+	15	2112	c.1718C>G	c.(1717-1719)tCc>tGc	p.S573C	KIAA0195_ENST00000375248.5_Missense_Mutation_p.S583C|KIAA0195_ENST00000579208.1_Missense_Mutation_p.S224C	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	573					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	p.S573Y(1)		breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTTGATGACTCCAACTGGCAG	0.592000													20	28					0	0	1	0	0
TMEM59L	25789	broad.mit.edu	37	19	18726859	18726859	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:18726859C>T	ENST00000600490.1	+	5	668	c.483C>T	c.(481-483)gtC>gtT	p.V161V	TMEM59L_ENST00000262817.3_Silent_p.V161V			Q9UK28	TM59L_HUMAN	transmembrane protein 59-like	161						Golgi membrane|integral to membrane|membrane fraction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(2)	13						ATGACCTTGTCAACTCAGCCC	0.527000													65	57					0	0	1	0	0
TCF7	6932	broad.mit.edu	37	5	133482119	133482119	+	Silent	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr5:133482119C>G	ENST00000395029.1	+	11	1548	c.1353C>G	c.(1351-1353)ctC>ctG	p.L451L	TCF7_ENST00000342854.5_3'UTR|TCF7_ENST00000395023.1_3'UTR|TCF7_ENST00000520958.1_3'UTR|TCF7_ENST00000432532.2_Silent_p.L336L|TCF7_ENST00000378560.4_3'UTR			P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific, HMG-box)	196					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding			kidney(2)|large_intestine(7)|lung(2)|skin(1)	12		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCACTGCTCTCAGCCTCCCAA	0.637000											OREG0016787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	0					0	0	1	0	0
NGDN	25983	broad.mit.edu	37	14	23938934	23938934	+	Silent	SNP	C	C	T			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr14:23938934C>T	ENST00000397154.3	+	1	23	c.10C>T	c.(10-12)Ctg>Ttg	p.L4L	NGDN_ENST00000408901.3_Silent_p.L4L			Q8NEJ9	NGDN_HUMAN	neuroguidin, EIF4E binding protein	4					regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	12	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GATGGCGGCGCTGGTGAGTTT	0.542000											OREG0022601	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	38					0	0	1	0	0
SHMT1	6470	broad.mit.edu	37	17	18250863	18250863	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:18250863C>G	ENST00000316694.3	-	5	600	c.466G>C	c.(466-468)Gac>Cac	p.D156H	SHMT1_ENST00000352886.6_Missense_Mutation_p.D156H|SHMT1_ENST00000354098.3_Missense_Mutation_p.D156H|SHMT1_ENST00000539052.1_Missense_Mutation_p.D18H	NM_004169.3	NP_004160.3	P34896	GLYC_HUMAN	serine hydroxymethyltransferase 1 (soluble)	156					carnitine biosynthetic process|folic acid metabolic process|L-serine catabolic process|one-carbon metabolic process|purine base biosynthetic process	cytosol|nucleus	glycine hydroxymethyltransferase activity|protein homodimerization activity|pyridoxal phosphate binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)	13					Glycine(DB00145)|Mimosine(DB01055)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	TTCTTCTTGTCTGTCATGAAC	0.507000													30	78					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53677948	53677948	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr12:53677948A>G	ENST00000257934.4	+	17	3275	c.3184A>G	c.(3184-3186)Aca>Gca	p.T1062A	ESPL1_ENST00000552462.1_Missense_Mutation_p.T1062A	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	1062					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						TGAGTCTTGCACAGGTGAGCA	0.502000													34	59					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107845255	107845255	+	Silent	SNP	T	T	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:107845255T>C	ENST00000285311.3	-	4	1341	c.636A>G	c.(634-636)gaA>gaG	p.E212E	DKK2_ENST00000513208.1_Silent_p.E112E|DKK2_ENST00000510463.1_Silent_p.E166E	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	212	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		TGGTACAGACTTCCCCCTGAT	0.502000													13	137					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													5	29					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31815698	31815698	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:31815698C>G	ENST00000446923.2	+	9	3224	c.2833C>G	c.(2833-2835)Caa>Gaa	p.Q945E	ZEB1_ENST00000361642.5_Missense_Mutation_p.Q962E|ZEB1_ENST00000320985.10_Missense_Mutation_p.Q961E|ZEB1_ENST00000560721.2_Missense_Mutation_p.Q941E|ZEB1_ENST00000542815.3_Missense_Mutation_p.Q894E	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	961					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AAAGCCCTATCAATGTGACAA	0.403000													13	31					0	0	1	0	0
EDAR	10913	broad.mit.edu	37	2	109524314	109524315	+	Splice_Site	INS	-	-	C			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr2:109524314_109524315insC	ENST00000409271.1	-	10	1503		c.e10+1		EDAR_ENST00000258443.2_Splice_Site|EDAR_ENST00000376651.1_Splice_Site			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor						apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						CAGGAGCCTCACCCCGGCTGAC	0.604													10	97	---	---	---	---					
NAA15	80155	broad.mit.edu	37	4	140281650	140281653	+	Splice_Site	DEL	ATAG	ATAG	-			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr4:140281650_140281653delATAG	ENST00000296543.5	+	13	1733		c.e13-1		NAA15_ENST00000398947.1_Splice_Site	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit						angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						TGATTTCTGTATAGGAAGGAACAT	0.338													8	62	---	---	---	---					
KCTD16	57528	broad.mit.edu	37	5	143853531	143853531	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr5:143853531delA	ENST00000507359.3	+	3	2232	c.1141delA	c.(1141-1143)aaafs	p.K383fs	KCTD16_ENST00000512467.1_Frame_Shift_Del_p.K383fs	NM_020768.3	NP_065819.1	Q68DU8	KCD16_HUMAN	potassium channel tetramerization domain containing 16							cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(5)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	21		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			CATGAGCAGCAAAAAAAAAGC	0.468													8	84	---	---	---	---					
HLA-V	352962	broad.mit.edu	37	6	29760353	29760373	+	RNA	DEL	GCGGGCGCCGTGGATGGAGCA	GCGGGCGCCGTGGATGGAGCA	-	rs74661005	by1000genomes	TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr6:29760353_29760373delGCGGGCGCCGTGGATGGAGCA	ENST00000457107.1	+	0	223_243																											GGATGGAGCCGCGGGCGCCGTGGATGGAGCAGGAGGGGCCG	0.674													5	4	---	---	---	---					
BICC1	80114	broad.mit.edu	37	10	60461833	60461833	+	Splice_Site	DEL	G	G	-			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr10:60461833delG	ENST00000373886.3	+	3	241		c.e3-1			NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)						multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						TTTTGTTACAGATCATGGAGG	0.338													12	24	---	---	---	---					
HAMP	57817	broad.mit.edu	37	19	35773520	35773522	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-ZF-A9R2-01A-11D-A391-08	TCGA-ZF-A9R2-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afc5550b-014e-421f-b15d-d71f605f7f23	ac404474-a7e1-4106-8b0b-8f32841c4402	g.chr19:35773520_35773522delCTC	ENST00000598398.1	+	2	336_338	c.40_42delCTC	c.(40-42)ctcdel	p.L18del	HAMP_ENST00000222304.3_In_Frame_Del_p.L18del	NM_021175.2	NP_066998.1	P81172	HEPC_HUMAN	hepcidin antimicrobial peptide	18					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)	4	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TTGCCTCCTGCTCCTCCTCCTCC	0.640													8	207	---	---	---	---					
