Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PIK3R3	8503	broad.mit.edu	37	1	46532610	46532610	+	Silent	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:46532610C>A	ENST00000262741.5	-	4	1157	c.468G>T	c.(466-468)ctG>ctT	p.L156L	PIK3R3_ENST00000420542.1_Silent_p.L156L|PIK3R3_ENST00000540385.1_Silent_p.L202L|PIK3R3_ENST00000423209.1_Silent_p.L156L|PIK3R3_ENST00000372006.1_Silent_p.L156L|PIK3R3_ENST00000340332.6_Silent_p.L120L|PIK3R3_ENST00000354242.4_Silent_p.L156L	NM_003629.3	NP_003620.3	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	156	SH2 1.				insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding			endometrium(1)|large_intestine(5)|lung(6)|prostate(2)	14	Acute lymphoblastic leukemia(166;0.155)					CTGGGTACATCAGCTTCACAT	0.388000													30	87					1.08312e-15	1.13776e-15	1	1	0
AP1G2	8906	broad.mit.edu	37	14	24029581	24029581	+	Silent	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:24029581C>A	ENST00000308724.5	-	19	2795	c.2040G>T	c.(2038-2040)ctG>ctT	p.L680L	AP1G2_ENST00000397120.3_Silent_p.L680L|RP11-66N24.4_ENST00000553985.1_RNA	NM_003917.2	NP_003908.1	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2 subunit	680	GAE.				interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	28	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		AAGACAGATTCAGCTGTACTC	0.498000											OREG0022604	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	20					8.12818e-05	8.30412e-05	1	1	0
TJP3	27134	broad.mit.edu	37	19	3746488	3746488	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:3746488G>A	ENST00000541714.2	+	17	2478	c.2016G>A	c.(2014-2016)aaG>aaA	p.K672K	TJP3_ENST00000539908.2_Silent_p.K636K|TJP3_ENST00000382008.3_Silent_p.K686K|TJP3_ENST00000262968.9_Silent_p.K705K|TJP3_ENST00000589378.1_Silent_p.K681K|TJP3_ENST00000587686.1_Silent_p.K691K	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	686	Guanylate kinase-like.					tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGGACAAGCATGCGCTCC	0.597000													10	37					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99139129	99139129	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:99139129G>A	ENST00000370992.4	-	15	1830	c.1719C>T	c.(1717-1719)atC>atT	p.I573I	RRP12_ENST00000536831.1_Silent_p.I291I|RRP12_ENST00000315563.6_Silent_p.I473I|RRP12_ENST00000414986.1_Silent_p.I512I	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	573						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		CATGGTCTCGGATGACAGGCA	0.557000													13	97					0	0	1	0	0
TRIM37	4591	broad.mit.edu	37	17	57089751	57089751	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:57089751T>A	ENST00000376149.3	-	22	3076	c.2267A>T	c.(2266-2268)aAt>aTt	p.N756I	TRIM37_ENST00000393065.2_Missense_Mutation_p.N844I|TRIM37_ENST00000393066.3_Missense_Mutation_p.N878I|TRIM37_ENST00000262294.7_Missense_Mutation_p.N878I			O94972	TRI37_HUMAN	tripartite motif containing 37	878						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					AGTTTCAGAATTATTTTCCAA	0.398000									Mulibrey Nanism				5	75					0	0	1	0	0
NBPF18P	441908	broad.mit.edu	37	1	151993799	151993799	+	RNA	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:151993799C>G	ENST00000432386.1	+	0	2634					NR_103561.1																						GGCAGGATATCTGAGAGCAGC	0.577000													6	57					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7636551	7636551	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:7636551G>A	ENST00000572933.1	+	5	2006	c.546G>A	c.(544-546)caG>caA	p.Q182Q	DNAH2_ENST00000082259.3_Silent_p.Q182Q|DNAH2_ENST00000389173.2_Silent_p.Q182Q|DNAH2_ENST00000570791.1_Silent_p.Q182Q			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	182	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TTGCCCCTCAGATCTTTGCAA	0.557000													13	78					0	0	1	0	0
PRAMEF22	653606	broad.mit.edu	37	1	13036262	13036262	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:13036262G>A	ENST00000376187.1	+	2	334	c.334G>A	c.(334-336)Gag>Aag	p.E112K	PRAMEF6_ENST00000376192.5_Intron	NM_001100631.1	NP_001094101.1	A3QJZ6	PRA22_HUMAN	PRAME family member 22	112										kidney(1)|large_intestine(2)|lung(1)|skin(1)	5						GGATGTTGATGAGAATTTTTG	0.542000													33	203					0	0	1	0	0
DNAJA1	3301	broad.mit.edu	37	9	33036681	33036681	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:33036681C>T	ENST00000330899.4	+	7	1051	c.868C>T	c.(868-870)Cat>Tat	p.H290Y	DNAJA1_ENST00000495015.1_3'UTR|DNAJA1_ENST00000544625.1_Missense_Mutation_p.H133Y	NM_001539.2	NP_001530.1	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	290					protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding			large_intestine(2)|ovary(1)|skin(3)	6			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		CATCACCTCTCATCCAGGTAT	0.428000													9	22					0	0	1	0	0
ITPRIPL2	162073	broad.mit.edu	37	16	19126540	19126540	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:19126540C>T	ENST00000381440.3	+	1	1287	c.757C>T	c.(757-759)Cgc>Tgc	p.R253C	CTD-2349B8.1_ENST00000564808.2_Intron	NM_001034841.3	NP_001030013.1	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 2	253						integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						TCTGGTGCTGCGCTGGTTCCA	0.662000											OREG0023657	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	73					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21737789	21737789	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:21737789C>T	ENST00000328843.6	+	37	6190	c.6159C>T	c.(6157-6159)ttC>ttT	p.F2053F	DNAH11_ENST00000409508.3_Silent_p.F2046F			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2053	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CCCGAAAGTTCATTACGTTGT	0.433000									Kartagener syndrome				4	30					0	0	1	0	0
TXNDC16	57544	broad.mit.edu	37	14	52948972	52948972	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:52948972T>C	ENST00000281741.4	-	14	1659	c.1288A>G	c.(1288-1290)Att>Gtt	p.I430V	TXNDC16_ENST00000554399.1_Intron	NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	430	Thioredoxin.				cell redox homeostasis	extracellular region				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					GCCACATCAATATAGGATTGC	0.328000													8	35					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32911628	32911628	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:32911628G>A	ENST00000544455.1	+	11	3363	c.3136G>A	c.(3136-3138)Gaa>Aaa	p.E1046K	BRCA2_ENST00000380152.3_Missense_Mutation_p.E1046K	NM_000059.3	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1046					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGCTTGTGTTGAAATTGTAAA	0.318000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			9	62					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49044877	49044877	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:49044877G>A	ENST00000395474.3	+	1	383	c.103G>A	c.(103-105)Gag>Aag	p.E35K	WDR6_ENST00000608424.1_Missense_Mutation_p.E5K|WDR6_ENST00000415265.2_Missense_Mutation_p.E5K|WDR6_ENST00000489684.1_3'UTR	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	5					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		GGACGCTCTCGAGGACTACGT	0.657000													4	3					0	0	1	0	0
SCAP	22937	broad.mit.edu	37	3	47476592	47476592	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:47476592C>T	ENST00000265565.5	-	3	570	c.158G>A	c.(157-159)gGa>gAa	p.G53E	SCAP_ENST00000545718.1_5'UTR|SCAP_ENST00000441517.2_5'UTR	NM_012235.2	NP_036367.2	Q12770	SCAP_HUMAN	SREBF chaperone	53					cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	26				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		TTCCACAGGTCCTGTTCCTGG	0.537000													6	46					0	0	1	0	0
CA6	765	broad.mit.edu	37	1	9011493	9011493	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:9011493G>A	ENST00000480186.3	+	3	276	c.271G>A	c.(271-273)Gaa>Aaa	p.E91K	CA6_ENST00000377442.2_Intron|CA6_ENST00000377443.2_Intron|CA6_ENST00000377436.3_Intron|CA6_ENST00000476083.1_Intron			P23280	CAH6_HUMAN	carbonic anhydrase VI						one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(5)	16	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		TTGGCAGGCGGAACTCTTCCT	0.502000													3	13					0	0	1	0	0
NDUFA8	4702	broad.mit.edu	37	9	124921923	124921923	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:124921923C>T	ENST00000537618.1	-	1	143	c.34G>A	c.(34-36)Gag>Aag	p.E12K	NDUFA8_ENST00000373768.3_Missense_Mutation_p.E12K			P51970	NDUA8_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa	12					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9					NADH(DB00157)	ACTTTCAGCTCCTCTAGAGTG	0.677000													11	74					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	21014084	21014084	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:21014084C>T	ENST00000247986.2	-	8	2045	c.1735G>A	c.(1735-1737)Gag>Aag	p.E579K	KIF17_ENST00000400463.3_Missense_Mutation_p.E579K|KIF17_ENST00000490034.1_Intron|KIF17_ENST00000375044.1_Missense_Mutation_p.E479K			Q9P2E2	KIF17_HUMAN	kinesin family member 17	579					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CCGAGGCACTCATCCAGGAAG	0.637000													11	32					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95662842	95662842	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:95662842G>A	ENST00000298912.4	-	10	2814	c.2701C>T	c.(2701-2703)Cct>Tct	p.P901S		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	901						integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		TACCTGGAAGGAATGCTGTAG	0.448000													5	53					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40841641	40841641	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:40841641C>T	ENST00000254691.5	+	1	356	c.157C>T	c.(157-159)Ctc>Ttc	p.L53F	CARD6_ENST00000381677.3_Missense_Mutation_p.L53F	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	53	CARD.				apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						TGTTACAGATCTCCTGAAGAA	0.403000													5	61					0	0	1	0	0
PRDM11	56981	broad.mit.edu	37	11	45246182	45246182	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:45246182C>T	ENST00000263765.4	+	8	1508	c.1259C>T	c.(1258-1260)tCa>tTa	p.S420L	PRDM11_ENST00000424263.2_Missense_Mutation_p.S386L|CTD-2560E9.3_ENST00000527450.1_RNA|PRDM11_ENST00000528980.1_Intron|PRDM11_ENST00000530656.1_Missense_Mutation_p.S420L			Q9NQV5	PRD11_HUMAN	PR domain containing 11	420										endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	26						GAGGAGCCTTCATCATTCAAG	0.567000													27	124					0	0	1	0	0
UGCG	7357	broad.mit.edu	37	9	114691933	114691933	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:114691933T>C	ENST00000374279.3	+	6	1162	c.712T>C	c.(712-714)Ttt>Ctt	p.F238L	UGCG_ENST00000495085.1_3'UTR	NM_003358.1	NP_003349.1	Q16739	CEGT_HUMAN	UDP-glucose ceramide glucosyltransferase	238					epidermis development|glucosylceramide biosynthetic process	Golgi membrane|integral to membrane|membrane fraction	ceramide glucosyltransferase activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|ovary(1)|urinary_tract(1)	12				OV - Ovarian serous cystadenocarcinoma(323;0.0433)	Miglustat(DB00419)	CGAAGATTACTTTATGGCCAA	0.358000													21	92					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134042141	134042141	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:134042141G>A	ENST00000220616.4	+	41	7152	c.7112G>A	c.(7111-7113)cGa>cAa	p.R2371Q	TG_ENST00000519543.1_Missense_Mutation_p.R504Q|TG_ENST00000377869.1_Missense_Mutation_p.R2314Q|TG_ENST00000542445.1_Missense_Mutation_p.R741Q	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2371					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ACCCACATCCGAGGATTTGGC	0.647000													7	18					0	0	1	0	0
NPLOC4	55666	broad.mit.edu	37	17	79536043	79536043	+	Splice_Site	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:79536043T>C	ENST00000374747.5	-	14	1577	c.1448A>G	c.(1447-1449)cAg>cGg	p.Q483R	NPLOC4_ENST00000331134.6_Splice_Site_p.Q483R|NPLOC4_ENST00000539314.1_Splice_Site_p.Q322R			Q8TAT6	NPL4_HUMAN	nuclear protein localization 4 homolog (S. cerevisiae)	483					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	11	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			AGAGCTCACCTGTGTCTCACC	0.363000													9	30					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123982412	123982412	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:123982412A>G	ENST00000306315.5	-	4	4100	c.3665T>C	c.(3664-3666)aTg>aCg	p.M1222T	ZNF608_ENST00000504926.1_Missense_Mutation_p.M795T	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1222						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TGTCTGCTTCATAGAGTCCAT	0.473000													10	51					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79030589	79030589	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:79030589G>A	ENST00000446378.2	+	2	6032	c.6001G>A	c.(6001-6003)Gag>Aag	p.E2001K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2001						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGGAAATGTAGAGAGAAACAT	0.408000													10	37					0	0	1	0	0
VEGFA	7422	broad.mit.edu	37	6	43738978	43738978	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:43738978G>A	ENST00000372067.3	+	1	1029	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K	VEGFA_ENST00000417285.2_Missense_Mutation_p.E179K|VEGFA_ENST00000372064.4_Missense_Mutation_p.E179K|VEGFA_ENST00000523950.1_5'UTR|VEGFA_ENST00000523873.1_5'UTR|VEGFA_ENST00000372055.4_Missense_Mutation_p.E179K|VEGFA_ENST00000425836.2_Missense_Mutation_p.E179K|VEGFA_ENST00000413642.3_Missense_Mutation_p.E179K|VEGFA_ENST00000372077.4_5'UTR|VEGFA_ENST00000324450.6_Missense_Mutation_p.E179K|VEGFA_ENST00000482630.2_Missense_Mutation_p.E179K|VEGFA_ENST00000520948.1_5'UTR	NM_001025366.2|NM_001025367.2|NM_001025368.2|NM_001025369.2|NM_001033756.2|NM_001171623.1|NM_001171624.1|NM_001171625.1|NM_001171626.1|NM_001171627.1|NM_001171629.1|NM_003376.5	NP_001020537.2|NP_001020538.2|NP_001020539|NP_001020540.2|NP_001028928.1|NP_001165094.1|NP_001165095.1|NP_001165096.1|NP_001165097.1|NP_001165098.1|NP_001165100.1|NP_003367.4	P15692	VEGFA_HUMAN	vascular endothelial growth factor A	152					basophil chemotaxis|cellular response to hypoxia|induction of positive chemotaxis|platelet activation|platelet degranulation|platelet-derived growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cell adhesion|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of leukocyte migration|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular permeability|regulation of cell shape|vascular endothelial growth factor receptor signaling pathway|vasculogenesis	cell surface|extracellular space|membrane|platelet alpha granule lumen	cell surface binding|chemoattractant activity|cytokine activity|fibronectin binding|growth factor activity|heparin binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|vascular endothelial growth factor receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	9	all_cancers(18;5.46e-07)|all_epithelial(2;5.96e-08)|Lung NSC(15;0.000157)|all_lung(25;0.000486)|Hepatocellular(11;0.00309)		all cancers(41;0.000413)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0742)|OV - Ovarian serous cystadenocarcinoma(102;0.196)		Atorvastatin(DB01076)|Bevacizumab(DB00112)|Carvedilol(DB01136)|Ginkgo biloba(DB01381)|Gliclazide(DB01120)|Minocycline(DB01017)|Ranibizumab(DB01270)|Simvastatin(DB00641)	TCGGGCCTCCGAAACCATGAA	0.697000													4	17					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28530352	28530352	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:28530352G>A	ENST00000401766.2	-	13	2168	c.1656C>T	c.(1654-1656)atC>atT	p.I552I	SLC6A4_ENST00000261707.3_Silent_p.I552I			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	552					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	AACTGCAAATGATGAACTAAA	0.363000													7	90					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11720921	11720921	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:11720921G>A	ENST00000381486.2	+	7	1164	c.864G>A	c.(862-864)aaG>aaA	p.K288K	GREB1_ENST00000263834.5_Silent_p.K288K|GREB1_ENST00000381483.2_Silent_p.K288K|GREB1_ENST00000234142.5_Silent_p.K288K|GREB1_ENST00000389825.3_Silent_p.K178K	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	288						integral to membrane		p.K288N(3)		breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		AACTGGCAAAGAATAACCTGT	0.567000													4	64					0	0	1	0	0
SDC2	6383	broad.mit.edu	37	8	97620618	97620618	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:97620618T>C	ENST00000302190.4	+	4	1283	c.362T>C	c.(361-363)aTg>aCg	p.M121T	SDC2_ENST00000522911.1_Missense_Mutation_p.M92T|SDC2_ENST00000518385.1_Missense_Mutation_p.M85T|SDC2_ENST00000519914.1_Missense_Mutation_p.M92T	NM_002998.3	NP_002989.2	P34741	SDC2_HUMAN	syndecan 2	121						integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			breast(1)|cervix(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|stomach(2)	16	Breast(36;3.41e-05)				Sargramostim(DB00020)	GAAAGGAAAATGGACCCAGCC	0.433000													5	46					0	0	1	0	0
P2RX7	5027	broad.mit.edu	37	12	121605309	121605309	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:121605309G>A	ENST00000328963.5	+	7	707	c.253G>A	c.(253-255)Gag>Aag	p.E85K	P2RX7_ENST00000541446.1_Intron|P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000377162.2_Intron|P2RX7_ENST00000535250.1_Missense_Mutation_p.E165K|P2RX7_ENST00000546057.1_Missense_Mutation_p.E255K			A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	255						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AATGGGCATTGAGATCTACTG	0.532000													13	98					0	0	1	0	0
B4GALT1	2683	broad.mit.edu	37	9	33113820	33113820	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:33113820C>A	ENST00000379731.4	-	5	1202	c.1016G>T	c.(1015-1017)cGc>cTc	p.R339L	B4GALT1_ENST00000535206.1_Intron|B4GALT1_ENST00000541851.1_Missense_Mutation_p.R86L	NM_001497.3	NP_001488.2	P15291	B4GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	339					oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	basolateral plasma membrane|brush border membrane|desmosome|external side of plasma membrane|extracellular region|glycocalyx|Golgi cisterna membrane|Golgi trans cisterna|integral to membrane	alpha-tubulin binding|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|beta-tubulin binding|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity|protein binding|protein homodimerization activity			endometrium(1)|large_intestine(7)|lung(4)|prostate(1)|skin(1)	14			LUSC - Lung squamous cell carcinoma(29;0.0084)	GBM - Glioblastoma multiforme(74;0.121)	N-Acetyl-D-glucosamine(DB00141)	GCGGATCATGCGACACCTCCC	0.453000													14	51					0.00244969	0.00248301	1	1	0
CDH26	60437	broad.mit.edu	37	20	58563965	58563965	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:58563965G>A	ENST00000348616.4	+	9	1330	c.1030G>A	c.(1030-1032)Gat>Aat	p.D344N	CDH26_ENST00000244047.5_Missense_Mutation_p.D344N	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	344	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CCAGCCTTTGGATTATGAGAC	0.547000													10	23					0	0	1	0	0
NUP62CL	54830	broad.mit.edu	37	X	106418347	106418347	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:106418347C>T	ENST00000372466.4	-	3	281	c.30G>A	c.(28-30)ttG>ttA	p.L10L	NUP62CL_ENST00000372461.3_Silent_p.L10L	NM_017681.2	NP_060151.2	Q9H1M0	N62CL_HUMAN	nucleoporin 62kDa C-terminal like	10					protein transport	nuclear pore	structural constituent of nuclear pore			lung(4)	4						CAGTGGAGGTCAAAGAATTTG	0.408000													21	66					0	0	1	0	0
TRIM33	51592	broad.mit.edu	37	1	115006170	115006170	+	Silent	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:115006170A>C	ENST00000358465.2	-	3	737	c.654T>G	c.(652-654)acT>acG	p.T218T	TRIM33_ENST00000369543.2_Silent_p.T218T	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	218					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCACAACTAGTACATACCT	0.294000			T	RET	papillary thyroid								5	81					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79434693	79434693	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:79434693G>A	ENST00000264895.6	+	65	10601	c.10161G>A	c.(10159-10161)ctG>ctA	p.L3387L		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3382					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CCTATGACCTGAGAGGCATCT	0.468000													38	43					0	0	1	0	0
BMP8A	353500	broad.mit.edu	37	1	39957912	39957912	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:39957912C>G	ENST00000331593.5	+	1	595	c.249C>G	c.(247-249)gcC>gcG	p.A83A		NM_181809.3	NP_861525.2	Q7Z5Y6	BMP8A_HUMAN	bone morphogenetic protein 8a	83					cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity			kidney(1)|large_intestine(2)|lung(1)|skin(1)	5	Lung NSC(20;2.08e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;9.69e-19)|Epithelial(16;9.34e-17)|all cancers(16;1.73e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGTACCACGCCATGGCTGGCG	0.771000													21	7					0	0	1	0	0
EIF3K	27335	broad.mit.edu	37	19	39125632	39125632	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:39125632G>A	ENST00000545173.2	+	7	575		c.e7-1		EIF3K_ENST00000592558.1_Splice_Site|EIF3K_ENST00000588934.1_Intron|EIF3K_ENST00000538434.1_Splice_Site|EIF3K_ENST00000248342.4_Splice_Site|EIF3K_ENST00000593149.1_Splice_Site			Q9UBQ5	EIF3K_HUMAN	eukaryotic translation initiation factor 3, subunit K						regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex|nucleus	protein binding|ribosome binding|translation initiation factor activity		EIF3K/CYP39A1(2)	central_nervous_system(1)|endometrium(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GTCACCTGCAGACAGCCAGCT	0.567000											OREG0025450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	29					0	0	1	0	0
IGKV1-12	28940	broad.mit.edu	37	2	89339927	89339927	+	RNA	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:89339927G>A	ENST00000480492.1	-	0	191																											CTAATACCCTGACTCGCCCGA	0.527000													16	212					0	0	1	0	0
PMS2	5395	broad.mit.edu	37	7	6048638	6048638	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:6048638C>T	ENST00000265849.7	-	1	118	c.13G>A	c.(13-15)Gag>Aag	p.E5K	PMS2_ENST00000382321.4_Missense_Mutation_p.E5K|PMS2_ENST00000469652.1_5'UTR|PMS2_ENST00000406569.3_Missense_Mutation_p.E5K	NM_000535.5	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	5					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CTCGAGCTCTCAGCTCGCTCC	0.652000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				14	49					0	0	1	0	0
PHYHIPL	84457	broad.mit.edu	37	10	60994203	60994203	+	Missense_Mutation	SNP	C	C	G	rs147685227		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:60994203C>G	ENST00000373880.4	+	2	510	c.246C>G	c.(244-246)caC>caG	p.H82Q	PHYHIPL_ENST00000373878.3_Missense_Mutation_p.H56Q	NM_032439.3	NP_115815.2	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein-like	82	Fibronectin type-III.									NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(3)|skin(1)|urinary_tract(1)	18						GCATTACACACTATTTTATTG	0.308000													6	48					0	0	1	0	0
IKBKAP	8518	broad.mit.edu	37	9	111665213	111665213	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:111665213G>T	ENST00000374647.5	-	16	2067	c.1760C>A	c.(1759-1761)tCt>tAt	p.S587Y	IKBKAP_ENST00000537196.1_Missense_Mutation_p.S238Y	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	587					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AATAGCCAGAGAAGGTGACTC	0.428000													7	36					0.00307968	0.0031171	1	1	0
KRT38	8687	broad.mit.edu	37	17	39594407	39594407	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:39594407C>T	ENST00000246646.3	-	6	1178	c.1179G>A	c.(1177-1179)gtG>gtA	p.V393V		NM_006771.3	NP_006762.3	O76015	KRT38_HUMAN	keratin 38	393	Coil 2.|Rod.					intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	29		Breast(137;0.000496)				GCCGGGTCTTCACGTCCAGCA	0.562000													23	81					0	0	1	0	0
CLPTM1	1209	broad.mit.edu	37	19	45477743	45477743	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:45477743C>T	ENST00000541297.2	+	4	780	c.315C>T	c.(313-315)aaC>aaT	p.N105N	CLPTM1_ENST00000546079.1_Silent_p.N17N|CLPTM1_ENST00000337392.5_Silent_p.N119N			O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane protein 1	119					cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		CAGACTTCAACGCCACGTCGG	0.557000													4	70					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109954657	109954657	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:109954657C>T	ENST00000342494.3	+	19	2639	c.2044C>T	c.(2044-2046)Cac>Tac	p.H682Y	UBE3B_ENST00000434735.2_Missense_Mutation_p.H682Y|UBE3B_ENST00000280774.5_Missense_Mutation_p.H682Y	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	682					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						GCATGTCACTCACATCACCAT	0.522000													5	25					0	0	1	0	0
SDAD1P1	157489	broad.mit.edu	37	8	26238287	26238287	+	RNA	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:26238287C>T	ENST00000519902.1	-	0	1661																											TTTTCATCTTCATCTTTTCCA	0.423000													8	41					0	0	1	0	0
OAS2	4939	broad.mit.edu	37	12	113416527	113416527	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:113416527G>A	ENST00000392583.2	+	1	321	c.114G>A	c.(112-114)gtG>gtA	p.V38V	OAS2_ENST00000342315.4_Silent_p.V38V|RP1-71H24.1_ENST00000552784.1_RNA|OAS2_ENST00000449768.2_Silent_p.V38V	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	38	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						ACGAGATGGTGAACACCATCT	0.572000													7	48					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123151145	123151145	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:123151145C>T	ENST00000264501.4	+	26	3475	c.3102C>T	c.(3100-3102)atC>atT	p.I1034I	KIAA1109_ENST00000495260.1_3'UTR|KIAA1109_ENST00000455637.1_Silent_p.I1034I|KIAA1109_ENST00000388738.3_Silent_p.I1034I			Q2LD37	K1109_HUMAN	KIAA1109	1034					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GGGAAGGAATCAGTGCTGCAA	0.398000													16	43					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	101023103	101023103	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:101023103C>G	ENST00000193391.7	-	3	575	c.388G>C	c.(388-390)Ggg>Cgg	p.G130R		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	130					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TCCTCACGCCCAGGAAGTCGA	0.408000													14	68					0	0	1	0	0
KRT19	3880	broad.mit.edu	37	17	39681206	39681206	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:39681206G>A	ENST00000361566.3	-	3	609	c.549C>T	c.(547-549)atC>atT	p.I183I		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				GCAGGCCGTTGATGTCGGCCT	0.572000													17	125					0	0	1	0	0
CPB1	1360	broad.mit.edu	37	3	148575327	148575327	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:148575327C>T	ENST00000491148.1	+	11	1399	c.1065C>T	c.(1063-1065)atC>atT	p.I355I	CPB1_ENST00000282957.4_Splice_Site_p.I355I|CPB1_ENST00000498639.1_3'UTR|RP11-680B3.2_ENST00000488190.1_RNA			P15086	CBPB1_HUMAN	carboxypeptidase B1 (tissue)	355					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	38			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTACAACAATCTGTGAGTCTT	0.473000													5	49					0	0	1	0	0
POLH	5429	broad.mit.edu	37	6	43578337	43578337	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:43578337G>A	ENST00000372236.4	+	10	1416	c.1121G>A	c.(1120-1122)gGa>gAa	p.G374E	POLH_ENST00000372226.1_Missense_Mutation_p.G374E|POLH_ENST00000535400.1_Missense_Mutation_p.G312E	NM_006502.2	NP_006493.1	Q9Y253	POLH_HUMAN	polymerase (DNA directed), eta	374					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			CGTGTACAAGGAGACAAACGC	0.493000								DNA polymerases (catalytic subunits)	Xeroderma Pigmentosum				8	46					0	0	1	0	0
ANLN	54443	broad.mit.edu	37	7	36489317	36489317	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:36489317A>T	ENST00000265748.2	+	23	3343	c.3122A>T	c.(3121-3123)cAg>cTg	p.Q1041L	ANLN_ENST00000396068.2_Missense_Mutation_p.Q1004L	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	1041	Localization to the cleavage furrow.|PH.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						ACCAGTCGTCAGATAGAACCA	0.368000													8	49					0	0	1	0	0
CYBRD1	79901	broad.mit.edu	37	2	172409896	172409896	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:172409896C>T	ENST00000321348.4	+	3	641	c.443C>T	c.(442-444)cCg>cTg	p.P148L	CYBRD1_ENST00000409484.1_Missense_Mutation_p.P90L|CYBRD1_ENST00000375252.3_Silent_p.S78S	NM_024843.3	NP_079119.3	Q53TN4	CYBR1_HUMAN	cytochrome b reductase 1	148	Cytochrome b561.				cellular iron ion homeostasis|electron transport chain|transmembrane transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			endometrium(1)|kidney(1)|large_intestine(3)|liver(2)|lung(3)	10						CCATGGGCTCCGCTTTCTCTC	0.363000													31	52					0	0	1	0	0
HLTF	6596	broad.mit.edu	37	3	148757904	148757904	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:148757904C>T	ENST00000310053.5	-	21	2609	c.2416G>A	c.(2416-2418)Gaa>Aaa	p.E806K	HLTF_ENST00000465259.1_Missense_Mutation_p.E805K|HLTF_ENST00000494055.1_Missense_Mutation_p.E806K|HLTF_ENST00000392912.2_Missense_Mutation_p.E806K	NM_003071.3|NM_139048.2	NP_003062.2|NP_620636.1	Q14527	HLTF_HUMAN	helicase-like transcription factor	806					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			AAATTATCTTCATGTATATCA	0.343000													14	49					0	0	1	0	0
LEPRE1	64175	broad.mit.edu	37	1	43223591	43223591	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:43223591C>G	ENST00000236040.4	-	5	983	c.943G>C	c.(943-945)Ggg>Cgg	p.G315R	LEPRE1_ENST00000296388.5_Missense_Mutation_p.G315R|LEPRE1_ENST00000397054.3_Missense_Mutation_p.G315R	NM_001243246.1	NP_001230175.1	Q32P28	P3H1_HUMAN	leucine proline-enriched proteoglycan (leprecan) 1	315					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			large_intestine(2)|lung(15)|ovary(5)|prostate(1)|urinary_tract(3)	26	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GTATAATTCCCAACTGCAAAG	0.438000													241	100					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12336805	12336805	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:12336805G>A	ENST00000358136.3	+	19	3290	c.3160G>A	c.(3160-3162)Gat>Aat	p.D1054N	VPS13D_ENST00000356315.4_Missense_Mutation_p.D1054N	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1054					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCACTTAACTGATGGAGCTAC	0.458000											OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	95					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124404846	124404846	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:124404846G>A	ENST00000303921.2	-	1	835	c.185C>T	c.(184-186)tCt>tTt	p.S62F		NM_005302.3	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	62						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GTCTCTTGCAGAATTTCCCGG	0.687000													3	22					0	0	1	0	0
ATP2A2	488	broad.mit.edu	37	12	110784080	110784080	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:110784080C>T	ENST00000395494.2	+	19	3416	c.2853C>T	c.(2851-2853)ctC>ctT	p.L951L	ATP2A2_ENST00000539276.2_Silent_p.L978L|ATP2A2_ENST00000308664.6_Silent_p.L978L			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	978					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						CCGTGATTCTCATGGATGAGA	0.552000													6	65					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179291017	179291017	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:179291017C>T	ENST00000356834.3	-	22	3221	c.3184G>A	c.(3184-3186)Gga>Aga	p.G1062R	TBC1D9B_ENST00000444477.2_Missense_Mutation_p.G203R|TBC1D9B_ENST00000518085.1_5'UTR|TBC1D9B_ENST00000355235.3_Missense_Mutation_p.G1045R|TBC1D9B_ENST00000519746.1_Missense_Mutation_p.G221R	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	1062						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCACCTCTCCGATGCGGAGC	0.617000													8	34					0	0	1	0	0
POR	5447	broad.mit.edu	37	7	75612892	75612892	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:75612892G>A	ENST00000394893.1	+	9	905	c.885G>A	c.(883-885)ctG>ctA	p.L295L	POR_ENST00000450476.1_Silent_p.L194L|POR_ENST00000419840.1_Silent_p.L109L|POR_ENST00000439269.1_Silent_p.L33L|POR_ENST00000545601.1_Silent_p.L103L|POR_ENST00000461988.1_Silent_p.L295L			P16435	NCPR_HUMAN	P450 (cytochrome) oxidoreductase	292	FAD-binding FR-type.				cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|lung(3)|ovary(1)	9					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	ACCGGAAGCTGAACCAGGGAA	0.592000													18	88					0	0	1	0	0
SPIRE2	84501	broad.mit.edu	37	16	89921019	89921019	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:89921019A>G	ENST00000378247.3	+	5	894	c.851A>G	c.(850-852)cAg>cGg	p.Q284R	SPIRE2_ENST00000393062.2_Missense_Mutation_p.Q284R	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	284	WH2 2.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		ATGCTGATGCAGGACATCCGG	0.652000													4	54					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873926	36873926	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:36873926A>G	ENST00000429976.2	-	21	7263	c.7016T>C	c.(7015-7017)aTa>aCa	p.I2339T	TRANK1_ENST00000428977.2_Missense_Mutation_p.I1789T|TRANK1_ENST00000301807.6_Missense_Mutation_p.I1789T	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2339					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TTTCCCTTCTATTCCTTTTAT	0.493000													7	99					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57569486	57569486	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:57569486T>G	ENST00000243077.3	+	23	4257	c.3791T>G	c.(3790-3792)cTg>cGg	p.L1264R		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1264					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGCCGCAGCCTGGGTGAGACA	0.612000											OREG0021937	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	50					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49739828	49739828	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:49739828G>A	ENST00000327697.6	+	19	1763	c.1619G>A	c.(1618-1620)aGt>aAt	p.S540N	RNF123_ENST00000432042.1_Missense_Mutation_p.S394N	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	540						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GAGAACGCCAGTGGCCGGGGG	0.577000													13	244					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32194825	32194825	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:32194825G>A	ENST00000492345.1	+	4	723	c.38G>A	c.(37-39)aGa>aAa	p.R13K	CBFA2T2_ENST00000346541.3_Missense_Mutation_p.R42K|CBFA2T2_ENST00000397798.2_Missense_Mutation_p.R13K|CBFA2T2_ENST00000397800.1_Missense_Mutation_p.R13K|CBFA2T2_ENST00000375279.2_Missense_Mutation_p.R42K|CBFA2T2_ENST00000342704.6_Missense_Mutation_p.R33K|CBFA2T2_ENST00000344201.3_Missense_Mutation_p.R13K|CBFA2T2_ENST00000359606.3_Missense_Mutation_p.R52K			O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	42						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						ATACAGTCCAGATCCTCACCT	0.522000													13	89					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9077432	9077432	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:9077432C>G	ENST00000397910.4	-	3	10217	c.10014G>C	c.(10012-10014)aaG>aaC	p.K3338N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3339	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCCAGTTGTCTTTGAAACCA	0.507000													8	72					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138619285	138619285	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:138619285T>C	ENST00000218099.2	+	2	212	c.205T>C	c.(205-207)Tgt>Cgt	p.C69R	F9_ENST00000479617.2_3'UTR|F9_ENST00000394090.2_Missense_Mutation_p.C69R	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	69	Gla.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	GGAAGAAAAGTGTAGTTTTGA	0.363000													11	55					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72822748	72822748	+	Splice_Site	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:72822748C>A	ENST00000268489.5	-	10	10100		c.e10-1		ZFHX3_ENST00000397992.5_Splice_Site	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3						muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GACGTTAAAGCTGAAAGGAAT	0.527000													3	64					1	1	1	1	0
USP25	29761	broad.mit.edu	37	21	17214771	17214771	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:17214771C>T	ENST00000285681.2	+	18	2618	c.2249C>T	c.(2248-2250)tCa>tTa	p.S750L	USP25_ENST00000285679.6_Missense_Mutation_p.S750L|USP25_ENST00000351097.5_Intron|USP25_ENST00000400183.2_Missense_Mutation_p.S750L	NM_001283042.1	NP_001269971.1	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	750					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		AGTGATTTCTCAAAGCACTTG	0.358000													7	81					0	0	1	0	0
ZBTB48	3104	broad.mit.edu	37	1	6640717	6640717	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:6640717C>T	ENST00000377674.4	+	2	206	c.48C>T	c.(46-48)ctC>ctT	p.L16L		NM_001278647.1|NM_001278648.1|NM_005341.2	NP_001265576.1|NP_001265577.1|NP_005332.1	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	16						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		TGCAGGAGCTCAACAAGCAGC	0.627000													17	29					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179529601	179529601	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:179529601A>G	ENST00000467460.1	-	11	1472	c.1142T>C	c.(1141-1143)gTc>gCc	p.V381A	PEX5L_ENST00000467440.2_5'UTR|PEX5L_ENST00000476138.1_Missense_Mutation_p.V338A|PEX5L_ENST00000263962.8_Missense_Mutation_p.V379A|PEX5L_ENST00000464614.1_Missense_Mutation_p.V273A|PEX5L_ENST00000468741.1_Missense_Mutation_p.V189A|PEX5L_ENST00000472994.1_Missense_Mutation_p.V322A|PEX5L_ENST00000485199.1_Missense_Mutation_p.V346A|PEX5L_ENST00000392649.3_Missense_Mutation_p.V273A|PEX5L_ENST00000465751.1_Missense_Mutation_p.V357A	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	381					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			CTGGAGGGCGACAATAGCTGC	0.433000													15	69					0	0	1	0	0
SLC47A2	146802	broad.mit.edu	37	17	19582095	19582095	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:19582095C>T	ENST00000350657.5	-	18	1821	c.1647G>A	c.(1645-1647)gtG>gtA	p.V549V	SLC47A2_ENST00000325411.5_Silent_p.V571V|SLC47A2_ENST00000463318.1_5'UTR	NM_001099646.1|NM_001256663.1	NP_001093116.1|NP_001243592.1	Q86VL8	S47A2_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 2	571						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(2)|kidney(3)|large_intestine(2)|lung(1)|ovary(1)	9	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					CCAGCTGTTTCACTGATAGTC	0.587000													4	34					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626976	108626976	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:108626976G>A	ENST00000264047.2	+	9	1678	c.1402G>A	c.(1402-1404)Gat>Aat	p.D468N	SLC5A7_ENST00000540517.1_Missense_Mutation_p.D363N|SLC5A7_ENST00000409059.1_Missense_Mutation_p.D468N	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	468					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	CTATTACCCTGATGATAATGG	0.413000													6	79					0	0	1	0	0
FAM3D	131177	broad.mit.edu	37	3	58622026	58622026	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:58622026C>T	ENST00000358781.2	-	9	890	c.580G>A	c.(580-582)Gag>Aag	p.E194K		NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	194					negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		CCCACCTGCTCAAAGGGGCTT	0.567000													12	51					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150445619	150445619	+	Silent	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:150445619T>C	ENST00000401000.4	+	10	4182	c.4117T>C	c.(4117-4119)Ttg>Ctg	p.L1373L	RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Silent_p.L1399L			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	1399	Pro-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TGGCCCCCCCTTGGGTCCCTC	0.617000													4	137					0	0	1	0	0
YWHAQ	10971	broad.mit.edu	37	2	9770312	9770312	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:9770312C>T	ENST00000381844.4	-	1	433	c.270G>A	c.(268-270)ctG>ctA	p.L90L	YWHAQ_ENST00000238081.3_Silent_p.L90L			P27348	1433T_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	90					negative regulation of transcription, DNA-dependent	centrosome|nucleus	protein N-terminus binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.241)		AGATGGATCTCAGCTCGGACT	0.572000													24	66					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57290598	57290598	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:57290598G>A	ENST00000543872.2	+	4	2678	c.2414G>A	c.(2413-2415)aGa>aAa	p.R805K	CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000300917.5_Missense_Mutation_p.R805K			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	805					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						ATCAGGACTAGAGCTGAAGAT	0.443000													15	108					0	0	1	0	0
RNF217	154214	broad.mit.edu	37	6	125283935	125283935	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:125283935G>A	ENST00000521654.2	+	1	245	c.245G>A	c.(244-246)cGa>cAa	p.R82Q	RP11-510H23.1_ENST00000439075.1_RNA|RNF217_ENST00000560949.1_5'UTR			Q8TC41	RN217_HUMAN	ring finger protein 217	0					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		AGTAAGAGCCGAGCACCGGCG	0.716000													3	15					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125397692	125397692	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:125397692G>A	ENST00000536769.1	-	1	2202	c.626C>T	c.(625-627)tCt>tTt	p.S209F	UBC_ENST00000339647.5_Missense_Mutation_p.S209F|UBC_ENST00000538617.1_Intron|UBC_ENST00000546120.1_Missense_Mutation_p.S133F			P0CG48	UBC_HUMAN	ubiquitin C	209	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GTTGTAGTCAGACAGGGTACG	0.493000													26	165					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76729438	76729438	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:76729438T>G	ENST00000287239.4	+	5	1240	c.751T>G	c.(751-753)Ttt>Gtt	p.F251V	KAT6B_ENST00000372724.1_Missense_Mutation_p.F251V|KAT6B_ENST00000372714.1_Missense_Mutation_p.F251V|KAT6B_ENST00000372711.1_Missense_Mutation_p.F251V|KAT6B_ENST00000372725.1_Missense_Mutation_p.F251V	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	251					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										CTGTTTGAAATTTTGTCCTGA	0.393000													5	27					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204413499	204413499	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:204413499G>A	ENST00000367187.3	-	18	3288	c.2732C>T	c.(2731-2733)tCa>tTa	p.S911L	PIK3C2B_ENST00000424712.2_Missense_Mutation_p.S883L	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	911					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			CTCAGCATCTGAGAGTGAGCC	0.577000													4	17					0	0	1	0	0
VASH1	22846	broad.mit.edu	37	14	77239638	77239638	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:77239638G>A	ENST00000554237.1	+	4	1107	c.614G>A	c.(613-615)tGa>tAa	p.*205*	VASH1_ENST00000556038.1_Intron|VASH1_ENST00000167106.4_Intron			Q7L8A9	VASH1_HUMAN	vasohibin 1	0					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space				breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|stomach(1)|urinary_tract(3)	10			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		ggggtaggttgaatgggctcc	0.587000													5	12					0	0	1	0	0
METTL18	92342	broad.mit.edu	37	1	169761939	169761939	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:169761939C>T	ENST00000310392.4	-	2	1251	c.898G>A	c.(898-900)Gat>Aat	p.D300N	METTL18_ENST00000303469.2_Missense_Mutation_p.D300N|C1orf112_ENST00000498289.1_Intron	NM_033418.2	NP_219486.1	O95568	MET18_HUMAN	methyltransferase like 18	300						cytoplasm	protein methyltransferase activity			kidney(1)|large_intestine(3)|lung(4)	8						CTATAATAATCTGGGTTGTAA	0.363000													14	57					0	0	1	0	0
POLDIP3	84271	broad.mit.edu	37	22	42997992	42997992	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:42997992T>G	ENST00000252115.5	-	3	625	c.521A>C	c.(520-522)aAc>aCc	p.N174T	POLDIP3_ENST00000339677.6_Intron|POLDIP3_ENST00000491021.1_5'UTR|POLDIP3_ENST00000348657.2_Intron|POLDIP3_ENST00000451060.2_Missense_Mutation_p.N18T	NM_032311.3	NP_115687.2	Q9BY77	PDIP3_HUMAN	polymerase (DNA-directed), delta interacting protein 3	174					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	16						GGCCTGGTGGTTATTGACAAC	0.493000													12	87					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17886294	17886294	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:17886294C>T	ENST00000594202.1	+	15	1254	c.975C>T	c.(973-975)ttC>ttT	p.F325F	FCHO1_ENST00000596536.1_Silent_p.F325F|FCHO1_ENST00000595033.1_Silent_p.F275F|FCHO1_ENST00000389133.4_Silent_p.F325F|FCHO1_ENST00000600676.1_Silent_p.F325F|FCHO1_ENST00000252771.7_Silent_p.F325F|FCHO1_ENST00000597512.1_Silent_p.F332F|FCHO1_ENST00000596951.1_Silent_p.F325F|FCHO1_ENST00000539407.1_Silent_p.F325F	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	325										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						AAGAAGGTTTCACTGTCCGGC	0.557000											OREG0025349	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	55					0	0	1	0	0
FAM83F	113828	broad.mit.edu	37	22	40415314	40415314	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:40415314T>C	ENST00000333407.6	+	2	726	c.632T>C	c.(631-633)cTg>cCg	p.L211P	FAM83F_ENST00000473717.1_Missense_Mutation_p.L43P	NM_138435.2	NP_612444.2	Q8NEG4	FA83F_HUMAN	family with sequence similarity 83, member F											breast(1)|endometrium(2)|large_intestine(1)|lung(4)|skin(4)|urinary_tract(2)	14						TGTCAGGACCTGCAGCTCACT	0.557000													17	53					0	0	1	0	0
LMNA	4000	broad.mit.edu	37	1	156106009	156106009	+	Missense_Mutation	SNP	C	C	T	rs58133342		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:156106009C>T	ENST00000368300.4	+	7	1374	c.1162C>T	c.(1162-1164)Cgc>Tgc	p.R388C	LMNA_ENST00000368299.3_Missense_Mutation_p.R388C|LMNA_ENST00000496738.1_3'UTR|LMNA_ENST00000473598.2_Missense_Mutation_p.R289C|LMNA_ENST00000368297.1_Missense_Mutation_p.R307C|LMNA_ENST00000448611.2_Missense_Mutation_p.R276C|LMNA_ENST00000392353.3_Missense_Mutation_p.R307C|LMNA_ENST00000368301.2_Missense_Mutation_p.R388C|LMNA_ENST00000347559.2_Missense_Mutation_p.R388C|LMNA_ENST00000361308.4_Missense_Mutation_p.R388C	NM_170707.3	NP_733821.1	P02545	LMNA_HUMAN	lamin A/C	388	Tail.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity			NS(1)|endometrium(1)|kidney(1)|lung(3)|ovary(4)	10	Hepatocellular(266;0.158)					CCCCAGGCTACGCCTGTCCCC	0.657000									Werner syndrome;Hutchinson-Gilford Progeria Syndrome				5	33					0	0	1	0	0
DNAJB9	4189	broad.mit.edu	37	7	108212384	108212384	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:108212384G>A	ENST00000249356.3	+	2	760	c.214G>A	c.(214-216)Gaa>Aaa	p.E72K	DNAJB9_ENST00000465725.1_3'UTR	NM_012328.2	NP_036460.1	Q9UBS3	DNJB9_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 9	72	J.				ER-associated protein catabolic process|protein folding	endoplasmic reticulum|nucleolus	heat shock protein binding|misfolded protein binding|unfolded protein binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13						AGAGATTGCAGAAGGTAAATA	0.408000													4	43					0	0	1	0	0
EIF6	3692	broad.mit.edu	37	20	33872189	33872189	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:33872189G>A	ENST00000374450.3	-	2	366	c.102C>T	c.(100-102)ttC>ttT	p.F34F	EIF6_ENST00000374436.3_Silent_p.F34F|EIF6_ENST00000462894.1_5'UTR|EIF6_ENST00000374443.3_Silent_p.F34F	NM_002212.3	NP_002203.1	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6	34					mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CGCACCTGTAGAAGTTCTCTG	0.657000													34	168					0	0	1	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43516842	43516842	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:43516842C>T	ENST00000430334.3	-	11	3193		c.e11+1		PLEKHM1_ENST00000580404.1_Splice_Site|PLEKHM1_ENST00000421073.2_Splice_Site	NM_014798.2	NP_055613.1	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 1						intracellular signal transduction	cytoplasm	metal ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26	Renal(3;0.0405)					GTCCCGCATACCTGACTGTGG	0.632000													6	23					0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42219615	42219615	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:42219615A>G	ENST00000221992.6	+	4	864	c.750A>G	c.(748-750)agA>agG	p.R250R	CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000405816.1_Silent_p.R250R|CEACAM5_ENST00000398599.4_Silent_p.R250R	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	250	Ig-like 3.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CATCTTACAGATCAGGGGAAA	0.502000													13	44					0	0	1	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43650935	43650935	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:43650935A>C	ENST00000374466.3	+	2	673	c.338A>C	c.(337-339)aAa>aCa	p.K113T	CSGALNACT2_ENST00000374464.1_Missense_Mutation_p.K113T	NM_018590.3	NP_061060.3	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 2	113					chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			endometrium(12)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CAGAGCAACAAAGAGCAAGCA	0.428000													14	56					0	0	1	0	0
SYBU	55638	broad.mit.edu	37	8	110587797	110587797	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:110587797C>T	ENST00000399066.3	-	6	2048	c.1321G>A	c.(1321-1323)Gag>Aag	p.E441K	SYBU_ENST00000276646.9_Missense_Mutation_p.E444K|SYBU_ENST00000528331.1_Missense_Mutation_p.E325K|SYBU_ENST00000529175.1_Missense_Mutation_p.E238K|SYBU_ENST00000440310.1_Missense_Mutation_p.E444K|SYBU_ENST00000408908.2_Missense_Mutation_p.E444K|SYBU_ENST00000424158.2_Missense_Mutation_p.E449K|SYBU_ENST00000533895.1_Missense_Mutation_p.E443K|SYBU_ENST00000532779.1_Missense_Mutation_p.E376K|SYBU_ENST00000528647.1_Missense_Mutation_p.E443K|SYBU_ENST00000422135.1_Missense_Mutation_p.E444K|SYBU_ENST00000529690.1_Missense_Mutation_p.E314K|SYBU_ENST00000433638.1_Missense_Mutation_p.E444K|SYBU_ENST00000533171.1_Missense_Mutation_p.E444K|SYBU_ENST00000533065.1_Missense_Mutation_p.E325K|SYBU_ENST00000446070.2_Missense_Mutation_p.E443K|SYBU_ENST00000408889.3_Missense_Mutation_p.E325K|SYBU_ENST00000419099.1_Missense_Mutation_p.E443K	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	444						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane		p.E441K(1)		NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						GTCACTATCTCATCGAACAAA	0.557000													6	51					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66358063	66358063	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:66358063C>T	ENST00000333861.3	-	1	2491	c.2424G>A	c.(2422-2424)aaG>aaA	p.K808K		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	808										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CACTCTTCATCTTGTCCAGGT	0.542000													28	301					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134053773	134053773	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:134053773C>T	ENST00000359428.5	+	24	3539	c.3395C>T	c.(3394-3396)cCt>cTt	p.P1132L	NUP214_ENST00000411637.2_Missense_Mutation_p.P1122L|NUP214_ENST00000451030.1_Missense_Mutation_p.P1133L			P35658	NU214_HUMAN	nucleoporin 214kDa	1132	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		AAGAATAACCCTGCAACCCCT	0.478000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""						OREG0019558	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	28					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29142012	29142012	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:29142012C>G	ENST00000377167.2	+	1	702	c.600C>G	c.(598-600)ctC>ctG	p.L200L		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						AGCTGACCCTCATGGTCATGA	0.478000													14	94					0	0	1	0	0
GLUL	2752	broad.mit.edu	37	1	182354934	182354934	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:182354934G>A	ENST00000311223.5	-	6	1460	c.564C>T	c.(562-564)gtC>gtT	p.V188V	GLUL_ENST00000491322.1_5'UTR|GLUL_ENST00000417584.2_Silent_p.V188V|GLUL_ENST00000331872.6_Silent_p.V188V|GLUL_ENST00000339526.4_Silent_p.V188V	NM_002065.5	NP_002056.2	P15104	GLNA_HUMAN	glutamate-ammonia ligase	188					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding			endometrium(2)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	16					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	CCGCAATCTTGACTCCAGCAT	0.517000													132	199					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4856951	4856951	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:4856951C>T	ENST00000536091.1	-	6	1618	c.1486G>A	c.(1486-1488)Gac>Aac	p.D496N	RADIL_ENST00000399583.3_Silent_p.L549L|RADIL_ENST00000538469.1_Silent_p.L309L			Q96JH8	RADIL_HUMAN	Ras association and DIL domains	881					cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CGCTGGCCGTCAGCGTGCAGG	0.642000													6	44					0	0	1	0	0
DENND4C	55667	broad.mit.edu	37	9	19346572	19346572	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:19346572G>A	ENST00000380432.2	+	18	2983	c.2950G>A	c.(2950-2952)Gaa>Aaa	p.E984K	DENND4C_ENST00000602925.1_Missense_Mutation_p.E1220K|DENND4C_ENST00000434457.2_Missense_Mutation_p.E1269K			Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	984						integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TCCTGATTCTGAAGATAAGTT	0.383000													13	76					0	0	1	0	0
RFX3	5991	broad.mit.edu	37	9	3346697	3346697	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:3346697C>T	ENST00000382004.3	-	4	496	c.185G>A	c.(184-186)gGa>gAa	p.G62E	RFX3_ENST00000381984.2_Missense_Mutation_p.G62E|RFX3_ENST00000358730.2_Missense_Mutation_p.G62E|RFX3_ENST00000302303.1_Missense_Mutation_p.G62E	NM_001282116.1|NM_134428.1	NP_001269045.1|NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)	62					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		AGTATCGCTTCCTTCCACATA	0.423000													4	41					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24199172	24199172	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:24199172C>T	ENST00000265769.4	+	16	1842	c.1732C>T	c.(1732-1734)Cgg>Tgg	p.R578W	RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|ADAM28_ENST00000397649.3_Missense_Mutation_p.R325W	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	578	Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CTGGAAAGGACGGATAGTGAC	0.428000													18	95					0	0	1	0	0
IQCB1	9657	broad.mit.edu	37	3	121489360	121489360	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:121489360C>A	ENST00000310864.6	-	15	1843	c.1629G>T	c.(1627-1629)agG>agT	p.R543S	IQCB1_ENST00000349820.6_Missense_Mutation_p.R410S	NM_001023570.2	NP_001018864.2	Q15051	IQCB1_HUMAN	IQ motif containing B1	543					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding			NS(1)|biliary_tract(1)|breast(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)	30				GBM - Glioblastoma multiforme(114;0.0983)		CTGCCACAGGCCTGGATCTAC	0.507000													49	128					7.47603e-22	7.86482e-22	1	1	0
GABRB3	2562	broad.mit.edu	37	15	26806166	26806166	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:26806166G>C	ENST00000541819.2	-	9	1263	c.1161C>G	c.(1159-1161)ttC>ttG	p.F387L	GABRB3_ENST00000545868.1_Missense_Mutation_p.F246L|GABRB3_ENST00000400188.3_Missense_Mutation_p.F260L|GABRB3_ENST00000299267.4_Missense_Mutation_p.F331L|GABRB3_ENST00000311550.5_Missense_Mutation_p.F331L			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	331					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CTCTTCCAAAGAAAATGTAGT	0.483000													6	46					0	0	1	0	0
ASMTL	8623	broad.mit.edu	37	X	1540609	1540609	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:1540609C>T	ENST00000534940.1	-	9	1238	c.1013G>A	c.(1012-1014)cGa>cAa	p.R338Q	ASMTL_ENST00000381333.4_Missense_Mutation_p.R380Q|ASMTL_ENST00000381317.3_Missense_Mutation_p.R396Q|ASMTL_ENST00000416733.2_Missense_Mutation_p.R320Q	NM_001173473.1	NP_001166944.1	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	396	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(9)|pancreas(1)|soft_tissue(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGTTCCCTCTCGGATGGCAAA	0.537000													179	330					0	0	1	0	0
ZNF256	10172	broad.mit.edu	37	19	58453833	58453833	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:58453833G>C	ENST00000282308.3	-	3	539	c.343C>G	c.(343-345)Cag>Gag	p.Q115E	ZNF256_ENST00000598928.1_3'UTR	NM_005773.2	NP_005764.2	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	115					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		TACAGTTTCTGACCATGGTGT	0.473000													16	86					0	0	1	0	0
RP11-192H23.4	0	broad.mit.edu	37	17	26940677	26940677	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:26940677G>A	ENST00000534850.1	-	2	136	c.105C>T	c.(103-105)gcC>gcT	p.A35A	SPAG5-AS1_ENST00000424210.1_RNA|SPAG5-AS1_ENST00000414744.1_RNA|SPAG5-AS1_ENST00000554154.1_RNA|SGK494_ENST00000301037.5_Silent_p.A35A|RP11-192H23.4_ENST00000577790.1_Silent_p.A34A|SGK494_ENST00000469832.3_5'UTR																endometrium(2)|kidney(2)	4						TCCAGCCTCGGGCCCAGGGAC	0.577000											OREG0024279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	51					0	0	1	0	0
OGFRL1	79627	broad.mit.edu	37	6	72011421	72011421	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:72011421T>C	ENST00000370435.4	+	7	1159	c.1025T>C	c.(1024-1026)aTg>aCg	p.M342T	RP11-154D6.1_ENST00000588612.1_RNA|RP11-154D6.1_ENST00000432050.1_RNA|RP3-331H24.5_ENST00000602823.1_lincRNA|RP11-154D6.1_ENST00000423255.1_RNA|RP11-154D6.1_ENST00000587253.1_RNA|RP11-154D6.1_ENST00000586030.1_RNA|RP11-154D6.1_ENST00000586232.1_RNA|RP11-154D6.1_ENST00000591156.1_RNA|RP11-154D6.1_ENST00000412751.1_RNA	NM_024576.3	NP_078852.3	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	342						membrane	receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|upper_aerodigestive_tract(1)	13						CAAACTTCTATGCACAAAAAA	0.448000													8	49					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68643048	68643048	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:68643048C>T	ENST00000423218.2	-	9	1062	c.967G>A	c.(967-969)Gac>Aac	p.D323N	ITGA11_ENST00000315757.7_Missense_Mutation_p.D323N			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	323	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	TCATCAGGGTCACTGGCGATG	0.507000													6	51					0	0	1	0	0
SNHG7	84973	broad.mit.edu	37	9	139620419	139620419	+	RNA	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:139620419G>A	ENST00000414282.1	-	0	451				SNHG7_ENST00000436596.1_RNA|SNHG7_ENST00000416970.1_RNA|SNHG7_ENST00000447221.1_RNA																							CCGAGCTTCAGATACACACAC	0.527000													11	14					0	0	1	0	0
MTERFD3	80298	broad.mit.edu	37	12	107371459	107371459	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:107371459T>G	ENST00000552029.1	-	2	3102	c.1034A>C	c.(1033-1035)aAg>aCg	p.K345T	MTERFD3_ENST00000240050.4_Missense_Mutation_p.K345T|MTERFD3_ENST00000392830.2_Missense_Mutation_p.K345T|C12orf23_ENST00000551237.1_Intron			Q49AM1	MTER3_HUMAN	MTERF domain containing 3	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding			breast(1)|kidney(1)|large_intestine(2)|lung(3)	7						ATGTCCATCCTTTATTCTGTA	0.373000													9	150					0	0	1	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	159610017	159610017	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:159610017C>T	ENST00000460298.1	+	7	1571	c.1330C>T	c.(1330-1332)Cag>Tag	p.Q444*	IQCJ-SCHIP1_ENST00000485419.1_Intron|IQCJ-SCHIP1_ENST00000412423.2_Intron|SCHIP1_ENST00000445224.2_Intron|IQCJ-SCHIP1_ENST00000337808.6_Intron|IQCJ-SCHIP1_ENST00000476809.1_Intron|IQCJ-SCHIP1_ENST00000527095.1_Intron|SCHIP1_ENST00000482804.1_Intron			Q9P0W5	SCHI1_HUMAN		0						cytoplasm	identical protein binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						AAGAAAAGCCCAGGGTGGTCT	0.473000													3	18					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685273	248685273	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:248685273C>G	ENST00000343414.4	+	1	358	c.326C>G	c.(325-327)tCg>tGg	p.S109W		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S109L(1)		NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGGTTGGGCTCGTCTGAGTGT	0.547000													16	51					0	0	1	0	0
C10orf137	26098	broad.mit.edu	37	10	127434457	127434457	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:127434457G>A	ENST00000337623.3	+	18	2775	c.2670G>A	c.(2668-2670)ctG>ctA	p.L890L	RP11-383C5.7_ENST00000594025.1_RNA|RP11-383C5.7_ENST00000600784.1_RNA|RP11-383C5.7_ENST00000593871.1_RNA|RP11-383C5.7_ENST00000602030.1_RNA|RP11-383C5.7_ENST00000449436.1_RNA|C10orf137_ENST00000356792.4_Silent_p.L924L	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	924					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GGGATGAACTGAAACGTGAAT	0.453000													12	57					0	0	1	0	0
ZIK1	284307	broad.mit.edu	37	19	58102569	58102569	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:58102569G>C	ENST00000597850.1	+	4	1605	c.1390G>C	c.(1390-1392)Gag>Cag	p.E464Q	ZIK1_ENST00000536878.2_Missense_Mutation_p.E451Q|ZIK1_ENST00000599456.1_Missense_Mutation_p.E409Q|ZIK1_ENST00000307468.4_3'UTR	NM_001010879.2	NP_001010879.2	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein 1	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	34		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAGGCCTTATGAGTGCAACAA	0.458000													10	66					0	0	1	0	0
PPWD1	23398	broad.mit.edu	37	5	64859170	64859170	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:64859170G>A	ENST00000261308.5	+	1	105	c.33G>A	c.(31-33)caG>caA	p.Q11Q	PPWD1_ENST00000538977.1_5'UTR|PPWD1_ENST00000535264.1_5'UTR	NM_015342.3	NP_056157.1	Q96BP3	PPWD1_HUMAN	peptidylprolyl isomerase domain and WD repeat containing 1	11					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	19		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00451)		ATTTTCAGCAGAGACGTAGAA	0.567000													7	25					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34554684	34554684	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:34554684C>T	ENST00000373381.4	-	2	474	c.298G>A	c.(298-300)Gag>Aag	p.E100K		NM_001281956.1|NM_052896.3	NP_001268885.1|NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	60	CUB 1.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTGTGCTGCTCTTCCGCGGTG	0.562000													10	21					0	0	1	0	0
MELK	9833	broad.mit.edu	37	9	36671006	36671006	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:36671006T>C	ENST00000543751.1	+	15	1566	c.1421T>C	c.(1420-1422)gTg>gCg	p.V474A	MELK_ENST00000536860.1_Missense_Mutation_p.V458A|MELK_ENST00000536329.1_Missense_Mutation_p.V435A|MELK_ENST00000545008.1_Missense_Mutation_p.V435A|MELK_ENST00000536987.1_Missense_Mutation_p.V375A|MELK_ENST00000541717.1_Missense_Mutation_p.V465A|MELK_ENST00000538311.1_Missense_Mutation_p.V312A|MELK_ENST00000298048.2_Missense_Mutation_p.V506A	NM_001256689.1	NP_001243618.1	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	506						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			TGCCGCTCAGTGGAATTGGAT	0.488000													20	47					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32828505	32828505	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:32828505C>T	ENST00000380250.3	+	51	7886	c.7390C>T	c.(7390-7392)Cta>Tta	p.L2464L		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CTTCGACTTCCTAGATGTGGA	0.468000													20	73					0	0	1	0	0
ANLN	54443	broad.mit.edu	37	7	36438905	36438905	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:36438905G>A	ENST00000265748.2	+	3	611	c.390G>A	c.(388-390)ctG>ctA	p.L130L	ANLN_ENST00000396068.2_Silent_p.L130L	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	130	Interaction with CD2AP.|Nuclear localization.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						GGAGAGGGCTGAACTCAAGAT	0.512000													4	59					0	0	1	0	0
HSPH1	10808	broad.mit.edu	37	13	31712594	31712594	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:31712594G>A	ENST00000320027.5	-	17	2664	c.2320C>T	c.(2320-2322)Ctt>Ttt	p.L774F	HSPH1_ENST00000380406.5_Missense_Mutation_p.L733F|HSPH1_ENST00000380405.4_Missense_Mutation_p.L730F|HSPH1_ENST00000445273.2_Missense_Mutation_p.L776F|HSPH1_ENST00000429785.2_Missense_Mutation_p.L593F	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	774					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TCCTGATCAAGACTCTTTTTA	0.388000													14	119					0	0	1	0	0
PNRC1	10957	broad.mit.edu	37	6	89793541	89793541	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:89793541C>T	ENST00000336032.3	+	2	727	c.610C>T	c.(610-612)Cac>Tac	p.H204Y	PNRC1_ENST00000354922.3_Missense_Mutation_p.H19Y|PNRC1_ENST00000369472.1_Missense_Mutation_p.H19Y	NM_006813.2	NP_006804.1	Q12796	PNRC1_HUMAN	proline-rich nuclear receptor coactivator 1	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(1)|large_intestine(2)|lung(3)	6		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)		TCATGGTATACACTTGTATGA	0.358000										Multiple Myeloma(7;0.094)			13	68					0	0	1	0	0
PPM1E	22843	broad.mit.edu	37	17	57057941	57057941	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:57057941T>C	ENST00000308249.2	+	7	1946	c.1817T>C	c.(1816-1818)tTa>tCa	p.L606S		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	615					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			ATTAATGAGTTAATGATGGAG	0.423000													4	106					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20180736	20180736	+	Missense_Mutation	SNP	G	G	A	rs76818231	byFrequency	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:20180736G>A	ENST00000400331.5	-	7	2700	c.2392C>T	c.(2392-2394)Cac>Tac	p.H798Y	MACC1_ENST00000332878.4_Missense_Mutation_p.H798Y|MACC1_ENST00000589011.1_Missense_Mutation_p.H798Y	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	798					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						TTTCCATAGTGAGCACTCCAG	0.378000													5	51					0	0	1	0	0
CAP1	10487	broad.mit.edu	37	1	40537150	40537150	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:40537150A>G	ENST00000372797.3	+	13	1934	c.1373A>G	c.(1372-1374)aAg>aGg	p.K458R	CAP1_ENST00000372792.2_Missense_Mutation_p.K458R|CAP1_ENST00000372798.1_Missense_Mutation_p.K457R|CAP1_ENST00000479759.1_3'UTR|CAP1_ENST00000340450.3_Missense_Mutation_p.K457R|CAP1_ENST00000372802.1_Missense_Mutation_p.K457R|CAP1_ENST00000372805.3_Missense_Mutation_p.K458R	NM_001105530.1|NM_006367.3	NP_001099000|NP_006358	Q01518	CAP1_HUMAN	CAP, adenylate cyclase-associated protein 1 (yeast)	458					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	12	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAGCAGTTCAAGACCCTATGG	0.468000													3	102					0	0	1	0	0
PSMB10	5699	broad.mit.edu	37	16	67969552	67969552	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:67969552C>G	ENST00000358514.4	-	5	769	c.432G>C	c.(430-432)ctG>ctC	p.L144L		NM_002801.3	NP_002792.1	P40306	PSB10_HUMAN	proteasome (prosome, macropain) subunit, beta type, 10	144					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|humoral immune response|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			NS(2)|endometrium(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		GCGGTCCAGTCAGGTCTACGC	0.662000													30	39					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13702441	13702441	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:13702441G>A	ENST00000357447.2	-	20	2141	c.1773C>T	c.(1771-1773)ctC>ctT	p.L591L	FRMD4A_ENST00000378503.1_Silent_p.L591L|FRMD4A_ENST00000358621.4_Silent_p.L576L	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	591						cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						GCATCTGTCGGAGTCCCTCCA	0.542000											OREG0020030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	87					0	0	1	0	0
CPQ	10404	broad.mit.edu	37	8	98078389	98078389	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:98078389C>A	ENST00000220763.5	+	7	1416	c.1206C>A	c.(1204-1206)agC>agA	p.S402R	CPQ_ENST00000529551.1_3'UTR	NM_016134.2	NP_057218.1	Q9Y646	PGCP_HUMAN	carboxypeptidase Q	402					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity										AGGTCCTGAGCCATGGAGAAG	0.483000													3	37					0.115264	0.115591	1	1	0
ZXDC	79364	broad.mit.edu	37	3	126194453	126194453	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:126194453C>T	ENST00000389709.3	-	1	309	c.256G>A	c.(256-258)Gct>Act	p.A86T	ZXDC_ENST00000336332.5_Missense_Mutation_p.A86T	NM_025112.4	NP_079388.3	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C	86					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(1)	17				GBM - Glioblastoma multiforme(114;0.155)		TCGGCGGCAGCGCCGCCGTGC	0.786000													4	13					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150730891	150730891	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:150730891G>C	ENST00000358849.4	+	2	388	c.295G>C	c.(295-297)Gaa>Caa	p.E99Q	ABCB8_ENST00000498578.1_Missense_Mutation_p.E99Q|ABCB8_ENST00000297504.6_Missense_Mutation_p.E116Q|ABCB8_ENST00000477719.1_Missense_Mutation_p.E99Q|ABCB8_ENST00000477092.1_Missense_Mutation_p.E99Q|ABCB8_ENST00000493338.1_3'UTR|ABCB8_ENST00000356058.4_Missense_Mutation_p.E136Q|ABCB8_ENST00000542328.1_Intron	NM_001282291.1|NM_001282293.1|NM_007188.3	NP_001269220.1|NP_001269222.1|NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	116						ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTGTGAGGCAGAAGAGGCCCC	0.632000													4	45					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138611013	138611013	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:138611013G>A	ENST00000251691.4	+	18	3121	c.2955G>A	c.(2953-2955)ctG>ctA	p.L985L		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	985					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GGGTGTGGCTGCACACTGCCC	0.527000													3	31					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133252082	133252082	+	Silent	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:133252082T>A	ENST00000320574.5	-	12	1171	c.1128A>T	c.(1126-1128)gcA>gcT	p.A376A	POLE_ENST00000535270.1_Silent_p.A349A	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	376					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CGTGGACTGCTGCCCGGGCCT	0.597000								DNA polymerases (catalytic subunits)					11	56					0	0	1	0	0
HSP90B1	7184	broad.mit.edu	37	12	104341429	104341429	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:104341429G>C	ENST00000299767.5	+	18	2583	c.2401G>C	c.(2401-2403)Gat>Cat	p.D801H		NM_003299.2	NP_003290.1	P14625	ENPL_HUMAN	heat shock protein 90kDa beta (Grp94), member 1	801					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(4)	29					Rifabutin(DB00615)	AGCTGAAAAAGATGAATTGTA	0.343000													15	30					0	0	1	0	0
DIO3	1735	broad.mit.edu	37	14	102028035	102028035	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:102028035C>G	ENST00000359323.3	+	1	348	c.124C>G	c.(124-126)Cgc>Ggc	p.R42G	DIO3_ENST00000510508.4_Missense_Mutation_p.R68G	NM_001362.3	NP_001353.4	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	42					cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(3)|skin(1)	22		all_neural(303;0.185)				CTTGTGTATCCGCAAGCATTT	0.662000													11	51					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120582452	120582452	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:120582452A>G	ENST00000300648.6	-	41	5355	c.5343T>C	c.(5341-5343)tgT>tgC	p.C1781C		NM_006836.1	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1781					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTTTGAGGATACAGGGGATGA	0.527000													7	92					0	0	1	0	0
FBXO3	26273	broad.mit.edu	37	11	33792317	33792317	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:33792317C>T	ENST00000530401.1	-	2	169	c.149G>A	c.(148-150)aGa>aAa	p.R50K	FBXO3_ENST00000534136.1_Missense_Mutation_p.R55K|FBXO3_ENST00000448981.2_Missense_Mutation_p.R55K|FBXO3_ENST00000533103.1_5'UTR|FBXO3_ENST00000265651.3_Missense_Mutation_p.R55K|FBXO3_ENST00000526785.1_5'UTR			Q9UK99	FBX3_HUMAN	F-box protein 3	55	F-box.				proteolysis	nucleus	ubiquitin-protein ligase activity			NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|pancreas(1)|stomach(1)	13		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		TTTGCAATGTCTTCTCCACAG	0.408000													79	228					0	0	1	0	0
USP19	10869	broad.mit.edu	37	3	49153530	49153530	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:49153530C>G	ENST00000453664.1	-	10	1709	c.1391G>C	c.(1390-1392)cGt>cCt	p.R464P	USP19_ENST00000398898.2_Missense_Mutation_p.R411P|USP19_ENST00000434032.2_Missense_Mutation_p.R474P|USP19_ENST00000417901.1_Missense_Mutation_p.R474P|USP19_ENST00000398896.1_Missense_Mutation_p.R179P|USP19_ENST00000398888.2_Missense_Mutation_p.R373P|USP19_ENST00000398892.3_Missense_Mutation_p.R411P	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	373					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTGCCTCTTACGAAGGCAGAT	0.597000													7	36					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31025057	31025057	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:31025057C>T	ENST00000375687.4	+	13	4966	c.4542C>T	c.(4540-4542)atC>atT	p.I1514I	ASXL1_ENST00000306058.5_Silent_p.I1509I	NM_015338.5	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	1514					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						AAGCCATGATCATGTGCCAAG	0.512000			"""F, N, Mis"""		"""MDS, CMML"""								7	80					0	0	1	0	0
TEX35	84066	broad.mit.edu	37	1	178491476	178491476	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:178491476G>A	ENST00000319416.2	+	9	715	c.603G>A	c.(601-603)gaG>gaA	p.E201E	TEX35_ENST00000258298.2_Intron|TEX35_ENST00000367639.1_Intron|TEX35_ENST00000367642.3_3'UTR|TEX35_ENST00000367641.3_3'UTR	NM_032126.4	NP_115502.2			testis expressed 35																		ttccttcagaggcctcaggcc	0.582000													9	7					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22216509	22216509	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:22216509G>A	ENST00000374695.3	-	6	618	c.539C>T	c.(538-540)tCt>tTt	p.S180F		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	180	SEA.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TCCCTGGGGAGAGGTGACGTA	0.617000													11	71					0	0	1	0	0
PAQR8	85315	broad.mit.edu	37	6	52268748	52268748	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:52268748G>C	ENST00000442253.2	+	2	911	c.737G>C	c.(736-738)tGg>tCg	p.W246S	PAQR8_ENST00000360726.3_Missense_Mutation_p.W246S	NM_133367.4	NP_588608.1	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member VIII	246					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(2)	17	Lung NSC(77;0.0875)					CAAGCAGCCTGGTACCACACC	0.587000													6	43					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102904540	102904540	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:102904540C>A	ENST00000359520.7	+	10	2802	c.2576C>A	c.(2575-2577)tCa>tAa	p.S859*	TECPR2_ENST00000558678.1_Nonsense_Mutation_p.S859*	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	859							protein binding	p.S859*(1)		breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						GTCTCGCCCTCAGGTTCGCCT	0.692000											OREG0022547	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	26					0.00116845	0.00118603	1	1	0
GPR133	283383	broad.mit.edu	37	12	131456122	131456122	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:131456122G>A	ENST00000261654.5	+	4	866	c.307G>A	c.(307-309)Gaa>Aaa	p.E103K	GPR133_ENST00000535015.1_Missense_Mutation_p.E135K	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	103					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GTGTGGCCCTGAAGGTGAGTG	0.517000													8	30					0	0	1	0	0
FBXO3	26273	broad.mit.edu	37	11	33763481	33763481	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:33763481G>A	ENST00000526785.1	-	10	4801	c.1050C>T	c.(1048-1050)cgC>cgT	p.R350R	FBXO3_ENST00000531080.1_Silent_p.R150R|FBXO3_ENST00000532057.1_Silent_p.R150R|FBXO3_ENST00000265651.3_Silent_p.R463R|FBXO3_ENST00000530401.1_3'UTR			Q9UK99	FBX3_HUMAN	F-box protein 3	463	ApaG.				proteolysis	nucleus	ubiquitin-protein ligase activity			NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|pancreas(1)|stomach(1)	13		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		AGCGGCGTCTGCGAATGGGAA	0.433000													10	25					0	0	1	0	0
KRTAP10-5	386680	broad.mit.edu	37	21	46000287	46000287	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:46000287C>T	ENST00000400372.1	-	1	194	c.169G>A	c.(169-171)Gag>Aag	p.E57K	TSPEAR_ENST00000323084.4_Intron	NM_198694.2	NP_941967.2	P60370	KR105_HUMAN	keratin associated protein 10-5	57	22 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(2)|kidney(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	14						GGGCTGGGCTCACAGGCCGCC	0.716000													18	79					0	0	1	0	0
C20orf195	79025	broad.mit.edu	37	20	62187587	62187587	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:62187587G>A	ENST00000370098.3	+	2	663	c.571G>A	c.(571-573)Gat>Aat	p.D191N	C20orf195_ENST00000370097.1_Missense_Mutation_p.D191N	NM_024059.2	NP_076964.1	Q9BVV2	CT195_HUMAN	chromosome 20 open reading frame 195	191										large_intestine(3)|lung(4)	7	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			CCTGGTGTCTGATGTCAGTGC	0.642000													10	107					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4933529	4933529	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:4933529C>T	ENST00000345988.2	-	22	5216	c.5127G>A	c.(5125-5127)gtG>gtA	p.V1709V	PPL_ENST00000590782.2_Silent_p.V1707V	NM_002705.4	NP_002696	O60437	PEPL_HUMAN	periplakin	1709					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TGTCGTGTATCACTGAGGACT	0.547000													5	37					0	0	1	0	0
ZNF823	55552	broad.mit.edu	37	19	11836082	11836082	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:11836082C>T	ENST00000341191.6	-	2	217	c.64G>A	c.(64-66)Ggt>Agt	p.G22S	ZNF823_ENST00000440527.1_Missense_Mutation_p.G22S|ZNF823_ENST00000545749.1_5'UTR	NM_001080493.2	NP_001073962.1	P16415	ZN823_HUMAN	zinc finger protein 823	22	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)	26						TGTGATGGACCCAGCAAAGCC	0.463000										HNSCC(68;0.2)			4	58					0	0	1	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134504030	134504030	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:134504030C>T	ENST00000372195.1	-	8	1166	c.923G>A	c.(922-924)aGa>aAa	p.R308K	RAPGEF1_ENST00000372189.3_Missense_Mutation_p.R291K|RAPGEF1_ENST00000372190.3_Missense_Mutation_p.R309K|RAPGEF1_ENST00000481260.1_5'UTR			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	291					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		CGCCGACTGTCTTTTCTTGGG	0.567000													15	32					0	0	1	0	0
ASTE1	28990	broad.mit.edu	37	3	130742938	130742938	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:130742938C>A	ENST00000264992.3	-	3	1654	c.1213G>T	c.(1213-1215)Gtg>Ttg	p.V405L	ASTE1_ENST00000514044.1_Missense_Mutation_p.V405L	NM_014065.2	NP_054784.2	Q2TB18	ASTE1_HUMAN	asteroid homolog 1 (Drosophila)	405					DNA repair		nuclease activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	22						ATCCTTTCCACTTCACTGAAA	0.413000													11	109					0.010729	0.0108285	1	1	0
MYH14	79784	broad.mit.edu	37	19	50792752	50792752	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:50792752A>G	ENST00000440075.2	+	35	4859	c.4812A>G	c.(4810-4812)gcA>gcG	p.A1604A	MYH14_ENST00000596571.1_Silent_p.A1563A|MYH14_ENST00000425460.1_Silent_p.A1571A|MYH14_ENST00000376970.2_Silent_p.A1596A|MYH14_ENST00000601313.1_Silent_p.A1604A|MYH14_ENST00000262269.8_Silent_p.A1604A|MYH14_ENST00000598205.1_Silent_p.A1571A			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1563					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		ATCTGCGAGCACAGGTGACAG	0.607000													4	19					0	0	1	0	0
RHOQ	23433	broad.mit.edu	37	2	46770263	46770263	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:46770263C>T	ENST00000238738.4	+	1	397	c.78C>T	c.(76-78)ctC>ctT	p.L26L	RHOQ_ENST00000465198.1_Intron	NM_012249.3	NP_036381.2	P17081	RHOQ_HUMAN	ras homolog family member Q	26					cortical actin cytoskeleton organization|insulin receptor signaling pathway|negative regulation of establishment of protein localization in plasma membrane|positive regulation of filopodium assembly|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	actin filament|cytosol|plasma membrane	GBD domain binding|GTP binding|GTPase activity|profilin binding			skin(2)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CGTGCCTACTCATGAGCTATG	0.682000													24	55					0	0	1	0	0
ZMAT3	64393	broad.mit.edu	37	3	178748730	178748730	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:178748730G>A	ENST00000311417.2	-	3	1069	c.328C>T	c.(328-330)Cct>Tct	p.P110S	ZMAT3_ENST00000432729.1_Missense_Mutation_p.P110S	NM_022470.3	NP_071915.1	Q9HA38	ZMAT3_HUMAN	zinc finger, matrin-type 3	110					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(1)|skin(1)	14	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			ATTCTAGCAGGAGGAGGACAG	0.458000													11	68					0	0	1	0	0
DEDD	9191	broad.mit.edu	37	1	161092094	161092094	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:161092094G>A	ENST00000392188.1	-	6	1124	c.890C>T	c.(889-891)tCt>tTt	p.S297F	DEDD_ENST00000545495.1_Missense_Mutation_p.S267F|DEDD_ENST00000489249.1_5'UTR|DEDD_ENST00000368006.3_Missense_Mutation_p.S267F|DEDD_ENST00000490843.2_Missense_Mutation_p.S267F|NIT1_ENST00000368008.1_Intron|DEDD_ENST00000458050.2_Missense_Mutation_p.S267F|DEDD_ENST00000368005.1_Missense_Mutation_p.S297F			O75618	DEDD_HUMAN	death effector domain containing	267					apoptosis|induction of apoptosis via death domain receptors|negative regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			cervix(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|skin(1)	10	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CTCTAATAAAGAGCCATTGAT	0.507000													27	71					0	0	1	0	0
NUDT16	131870	broad.mit.edu	37	3	131101022	131101022	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:131101022G>A	ENST00000359850.3	+	2	311	c.172G>A	c.(172-174)Gag>Aag	p.E58K	NUDT16_ENST00000502852.1_Missense_Mutation_p.E91K|NUDT16_ENST00000537561.1_Missense_Mutation_p.E45K|NUDT16_ENST00000521288.1_Missense_Mutation_p.E91K	NM_152395.2	NP_689608.2	Q96DE0	NUD16_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 16	91	Nudix hydrolase.					nucleolus|nucleoplasm	hydrolase activity|metal ion binding|RNA binding	p.E58K(2)		large_intestine(1)|lung(6)	7						TTTCCGCGTGGAGCGCACTGA	0.672000													10	32					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55620459	55620459	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:55620459G>T	ENST00000370830.3	-	7	1935	c.1237C>A	c.(1237-1239)Cac>Aac	p.H413N	BMP5_ENST00000446683.2_Missense_Mutation_p.H376N	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	413					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TTTGGTACGTGGTCAGGAAAC	0.308000													23	49					3.83957e-06	3.94832e-06	1	1	0
COL7A1	1294	broad.mit.edu	37	3	48623588	48623588	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:48623588G>A	ENST00000328333.8	-	27	3749	c.3642C>T	c.(3640-3642)ttC>ttT	p.F1214F	COL7A1_ENST00000454817.1_Silent_p.F1214F	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1214	Nonhelical region (NC1).|VWFA 2.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CATCCACGGCGAAGAAGGTCT	0.602000													25	158					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110984849	110984849	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:110984849C>A	ENST00000524391.1	-	3	1661	c.629G>T	c.(628-630)cGt>cTt	p.R210L	KCNV1_ENST00000297404.1_Missense_Mutation_p.R210L			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	210						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GCCAAAGATACGGGCAGCTGT	0.517000													21	36					4.35082e-09	4.52e-09	1	1	0
NBPF10	100132406	broad.mit.edu	37	1	145293183	145293183	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:145293183C>T	ENST00000468030.1	+	5	1040	c.704C>T	c.(703-705)tCa>tTa	p.S235L	NBPF10_ENST00000369339.3_Intron|NBPF10_ENST00000369338.1_5'UTR																							GCAGTGCTTTCAGCTCTGAGT	0.463000													7	29					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42764540	42764540	+	Splice_Site	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:42764540T>G	ENST00000261491.5	+	16	1935	c.1914T>G	c.(1912-1914)gtT>gtG	p.V638V	DGKH_ENST00000540693.1_Splice_Site_p.V638V|DGKH_ENST00000536612.1_Splice_Site_p.V502V|DGKH_ENST00000379274.2_Splice_Site_p.V502V|DGKH_ENST00000337343.4_Splice_Site_p.V638V|DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000538674.1_Splice_Site_p.V393V	NM_152910.4	NP_690874.2	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		TACCTGAAGTTATGGATGACC	0.383000													8	102					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1017841	1017841	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:1017841G>A	ENST00000421673.2	-	31	5010	c.4960C>T	c.(4960-4962)Cct>Tct	p.P1654S		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1654	Approximate repeats.|Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTCGGTGGAGGAATCGTGCCT	0.572000													19	456					0	0	1	0	0
RASAL2	9462	broad.mit.edu	37	1	178427408	178427408	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:178427408G>C	ENST00000448150.3	+	14	3766	c.2948G>C	c.(2947-2949)aGa>aCa	p.R983T	RASAL2_ENST00000462775.1_Missense_Mutation_p.R853T|RASAL2_ENST00000367649.3_Missense_Mutation_p.R994T	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	853					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						GTGCCAGATAGACACATACCT	0.542000													5	69					0	0	1	0	0
NFE2L3	9603	broad.mit.edu	37	7	26224967	26224967	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:26224967C>T	ENST00000056233.3	+	4	1908	c.1649C>T	c.(1648-1650)tCt>tTt	p.S550F		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	550					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						ATCCCTTTTTCTGTAGATGAA	0.408000													11	94					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30584813	30584813	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:30584813C>T	ENST00000562532.2	+	3	1467	c.1293C>T	c.(1291-1293)ttC>ttT	p.F431F		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7							integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GCATATTCTTCATGTGTGTCT	0.582000													21	64					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26241113	26241113	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:26241113A>T	ENST00000265944.5	+	3	240	c.74A>T	c.(73-75)gAg>gTg	p.E25V	MYO3A_ENST00000543632.1_Missense_Mutation_p.E25V|MYO3A_ENST00000376302.1_Missense_Mutation_p.E25V|MYO3A_ENST00000376301.1_Missense_Mutation_p.E25V	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	25	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity	p.E25_I27>I(1)		NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						GAAATCACTGAGACAATTGGC	0.328000													8	106					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18266949	18266949	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:18266949T>G	ENST00000377369.2	+	5	1143	c.870T>G	c.(868-870)aaT>aaG	p.N290K	SLC39A12_ENST00000377371.3_Missense_Mutation_p.N290K|SLC39A12_ENST00000377374.4_Missense_Mutation_p.N290K|SLC39A12_ENST00000539911.1_Missense_Mutation_p.N156K	NM_001145195.1|NM_001282733.1|NM_001282734.1	NP_001138667.1|NP_001269662.1|NP_001269663.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	290					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						ACTATTCTAATTTCTCTTCAT	0.373000													18	88					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30008930	30008930	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:30008930C>T	ENST00000346128.6	-	23	4561	c.4087G>A	c.(4087-4089)Gac>Aac	p.D1363N	TJP1_ENST00000356107.6_Missense_Mutation_p.D1363N|TJP1_ENST00000545208.2_Missense_Mutation_p.D1283N|TJP1_ENST00000400011.2_Missense_Mutation_p.D1287N	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	1363					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CTTCTTCGGTCAAAGTATGAC	0.428000													5	40					0	0	1	0	0
ZNF256	10172	broad.mit.edu	37	19	58453882	58453882	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:58453882G>C	ENST00000598928.1	-	2	367	c.167C>G	c.(166-168)tCt>tGt	p.S56C	ZNF256_ENST00000282308.3_Silent_p.V98V			Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	0	KRAB.				multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		TCTGTCTCAAGACTGGGCCAC	0.483000													21	112					0	0	1	0	0
ULK1	8408	broad.mit.edu	37	12	132404621	132404621	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:132404621C>G	ENST00000321867.4	+	26	3252	c.2901C>G	c.(2899-2901)ctC>ctG	p.L967L	ULK1_ENST00000540647.1_Silent_p.L212L	NM_003565.2	NP_003556	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	967					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		AGCAGCGGCTCCTGGACCGCA	0.632000													7	30					0	0	1	0	0
SRPK3	26576	broad.mit.edu	37	X	153049658	153049658	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:153049658G>A	ENST00000489426.1	+	16	3704	c.1338G>A	c.(1336-1338)ctG>ctA	p.L446L	SRPK3_ENST00000370108.3_Silent_p.L346L|SRPK3_ENST00000370100.1_Silent_p.L304L|SRPK3_ENST00000393786.3_Silent_p.L345L|SRPK3_ENST00000370104.1_Silent_p.L378L|SRPK3_ENST00000370101.3_Silent_p.L379L			Q9UPE1	SRPK3_HUMAN	SRSF protein kinase 3	379	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(2)|pancreas(2)|urinary_tract(1)	13	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGGCCTCCTGTCGCCTAGCA	0.642000													4	21					0	0	1	0	0
DENND4C	55667	broad.mit.edu	37	9	19332106	19332106	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:19332106C>G	ENST00000380432.2	+	13	1709	c.1676C>G	c.(1675-1677)cCt>cGt	p.P559R	DENND4C_ENST00000602925.1_Missense_Mutation_p.P795R|DENND4C_ENST00000434457.2_Missense_Mutation_p.P795R			Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	559						integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						GTTTCTCATCCTAAAGTCAGA	0.383000													18	66					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51749535	51749535	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:51749535C>G	ENST00000251076.5	-	36	8548	c.8261G>C	c.(8260-8262)gGa>gCa	p.G2754A	RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000543779.2_Missense_Mutation_p.G2755A|RP11-707P17.2_ENST00000559977.1_RNA|DMXL2_ENST00000449909.3_Missense_Mutation_p.G2118A	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2754						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		CACACTAGCTCCAGTGCTAGT	0.418000													14	23					0	0	1	0	0
PTPRCAP	5790	broad.mit.edu	37	11	67203345	67203345	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:67203345G>A	ENST00000326294.3	-	2	927	c.480C>T	c.(478-480)gtC>gtT	p.V160V		NM_005608.2	NP_005599.1	Q14761	PTCA_HUMAN	protein tyrosine phosphatase, receptor type, C-associated protein	160					defense response	integral to membrane|plasma membrane				skin(1)|upper_aerodigestive_tract(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			GGGAGCCGAGGACCAGGTCGC	0.687000													8	11					0	0	1	0	0
FAM151A	338094	broad.mit.edu	37	1	55077292	55077292	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:55077292G>A	ENST00000302250.2	-	6	1087	c.927C>T	c.(925-927)ttC>ttT	p.F309F	ACOT11_ENST00000371316.3_Intron|FAM151A_ENST00000371304.2_Intron	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	309						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CCAGCTGCTTGAACTGTGACA	0.567000													4	70					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31809156	31809156	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:31809156T>C	ENST00000446923.2	+	7	1236	c.845T>C	c.(844-846)gTg>gCg	p.V282A	ZEB1_ENST00000560721.2_Missense_Mutation_p.V278A|ZEB1_ENST00000320985.10_Missense_Mutation_p.V298A|ZEB1_ENST00000361642.5_Missense_Mutation_p.V299A|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000542815.3_Missense_Mutation_p.V231A	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	298					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TTGATACCTGTGAATGGGCGA	0.473000													7	45					0	0	1	0	0
TTC21A	199223	broad.mit.edu	37	3	39162558	39162558	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:39162558C>T	ENST00000301819.6	+	9	1172	c.995C>T	c.(994-996)tCg>tTg	p.S332L	TTC21A_ENST00000431162.2_Missense_Mutation_p.S332L|TTC21A_ENST00000440121.1_Missense_Mutation_p.S283L	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	332							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GCCACCCCCTCGTATGTCCAT	0.512000													40	95					0	0	1	0	0
MIOS	54468	broad.mit.edu	37	7	7625322	7625322	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:7625322G>A	ENST00000340080.4	+	7	2125	c.1704G>A	c.(1702-1704)aaG>aaA	p.K568K	MIOS_ENST00000405785.1_Silent_p.K568K	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)	568										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CGGATGAGAAGAACTCCCTTT	0.393000													18	87					0	0	1	0	0
GART	2618	broad.mit.edu	37	21	34900515	34900515	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:34900515T>C	ENST00000381831.3	-	10	1287	c.1024A>G	c.(1024-1026)Aaa>Gaa	p.K342E	GART_ENST00000381815.4_Missense_Mutation_p.K342E|GART_ENST00000381839.3_Missense_Mutation_p.K342E|GART_ENST00000361093.5_Missense_Mutation_p.K342E	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	342					'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	GGATAACCTTTACTTGCCATG	0.488000													34	71					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20769167	20769167	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:20769167C>A	ENST00000359062.3	+	4	1313	c.1273C>A	c.(1273-1275)Ctg>Atg	p.L425M	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	425					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TTCCTAGCGCCTGAGAAGGAG	0.428000													14	75					6.72482e-11	7.01721e-11	1	1	0
KIF20A	10112	broad.mit.edu	37	5	137519213	137519213	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:137519213T>C	ENST00000394894.3	+	9	1308	c.1082T>C	c.(1081-1083)gTg>gCg	p.V361A	KIF20A_ENST00000508792.1_Missense_Mutation_p.V343A	NM_005733.2	NP_005724.1	O95235	KI20A_HUMAN	kinesin family member 20A	361	Kinesin-motor.				cytokinesis|M phase of mitotic cell cycle|microtubule-based movement|protein transport|vesicle-mediated transport	Golgi apparatus|microtubule|nucleoplasm	ATP binding|microtubule motor activity|protein binding|transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|liver(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(1)	27			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTCCTAAAAGTGGGTCGTAAG	0.498000													34	65					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5789811	5789811	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:5789811C>T	ENST00000328090.5	+	15	5052	c.4427C>T	c.(4426-4428)tCt>tTt	p.S1476F		NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	1476																	ATGCAGGTCTCTGCCGAAATG	0.418000													7	46					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123844383	123844383	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:123844383G>A	ENST00000369005.1	+	4	2708	c.2368G>A	c.(2368-2370)Gac>Aac	p.D790N	TACC2_ENST00000334433.3_Missense_Mutation_p.D790N|TACC2_ENST00000453444.2_Missense_Mutation_p.D790N|TACC2_ENST00000515603.1_Missense_Mutation_p.D790N|TACC2_ENST00000515273.1_Missense_Mutation_p.D790N|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000358010.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	790						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTTGGCAGCAGACCTGGGGCT	0.637000													52	40					0	0	1	0	0
TYMP	1890	broad.mit.edu	37	22	50968116	50968116	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:50968116C>T	ENST00000252029.3	-	2	185	c.23G>A	c.(22-24)gGa>gAa	p.G8E	TYMP_ENST00000395678.3_Missense_Mutation_p.G8E|TYMP_ENST00000395681.1_Missense_Mutation_p.G8E|TYMP_ENST00000395680.1_Missense_Mutation_p.G8E	NM_001113755.2|NM_001113756.2|NM_001257988.1|NM_001257989.1|NM_001953.4	NP_001107227.1|NP_001107228.1|NP_001244917.1|NP_001244918.1|NP_001944.1	P19971	TYPH_HUMAN	thymidine phosphorylase	8					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			large_intestine(1)|lung(2)|ovary(1)|prostate(1)	5		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	GGCCCCGGTTCCCGGGGTCAT	0.716000													3	6					0	0	1	0	0
PPOX	5498	broad.mit.edu	37	1	161138868	161138868	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:161138868G>A	ENST00000367999.4	+	7	968	c.702G>A	c.(700-702)gaG>gaA	p.E234E	PPOX_ENST00000432542.2_Intron|PPOX_ENST00000535223.1_Intron|PPOX_ENST00000352210.5_Silent_p.E234E|PPOX_ENST00000544598.1_Intron|PPOX_ENST00000495483.1_3'UTR	NM_001122764.1	NP_001116236.1	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	234					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(3)	15	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GAGGTCTAGAGATGTTGCCTC	0.622000													24	75					0	0	1	0	0
GPRASP1	9737	broad.mit.edu	37	X	101910965	101910965	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:101910965C>G	ENST00000537097.1	+	6	2937	c.2124C>G	c.(2122-2124)ttC>ttG	p.F708L	GPRASP1_ENST00000415986.1_Missense_Mutation_p.F708L|GPRASP1_ENST00000444152.1_Missense_Mutation_p.F708L|GPRASP1_ENST00000361600.5_Missense_Mutation_p.F708L|RP4-769N13.7_ENST00000602441.1_RNA	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	708	Glu-rich.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						ATTCGTGGTTCTGGTCCAGAA	0.478000													14	25					0	0	1	0	0
PPP4R2	151987	broad.mit.edu	37	3	73108228	73108228	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:73108228G>A	ENST00000356692.5	+	4	581	c.328G>A	c.(328-330)Gat>Aat	p.D110N	PPP4R2_ENST00000295862.9_Missense_Mutation_p.D54N|PPP4R2_ENST00000394284.3_Missense_Mutation_p.D53N			Q9NY27	PP4R2_HUMAN	protein phosphatase 4, regulatory subunit 2	110					mRNA processing|protein modification process|regulation of double-strand break repair via homologous recombination|RNA splicing	centrosome|nucleus|protein phosphatase 4 complex	protein binding, bridging|protein phosphatase type 4 regulator activity			breast(2)|endometrium(1)|large_intestine(1)|lung(3)|skin(2)|stomach(1)|urinary_tract(2)	12		Prostate(10;0.0187)|Lung SC(41;0.236)		Epithelial(33;1.76e-07)|BRCA - Breast invasive adenocarcinoma(55;9.42e-05)|LUSC - Lung squamous cell carcinoma(21;0.00211)|Lung(16;0.00643)|KIRC - Kidney renal clear cell carcinoma(39;0.0164)|Kidney(39;0.0193)|OV - Ovarian serous cystadenocarcinoma(275;0.031)		ATTGTTAACAGATCCAAGGAG	0.313000													7	59					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109707788	109707788	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:109707788C>T	ENST00000356711.2	+	27	3240	c.3114C>T	c.(3112-3114)ttC>ttT	p.F1038F	MYO16_ENST00000357550.2_Silent_p.F1038F|MYO16_ENST00000457511.2_Silent_p.F550F	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1038	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CTCCACACTTCATTCATTGCA	0.403000													6	31					0	0	1	0	0
LIMS1	3987	broad.mit.edu	37	2	109300437	109300437	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:109300437G>A	ENST00000393310.1	+	10	1127	c.960G>A	c.(958-960)gaG>gaA	p.E320E	LIMS1_ENST00000410093.1_Silent_p.E324E|LIMS1_ENST00000409441.1_Silent_p.E357E|LIMS1_ENST00000542845.1_Silent_p.E382E|LIMS1_ENST00000544547.1_Silent_p.E332E|LIMS1_ENST00000332345.6_Silent_p.E320E|LIMS1_ENST00000338045.3_Silent_p.E320E	NM_001193488.1	NP_001180417.1	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	320					cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	10						AACTAGCTGAGACCTTAGGAA	0.333000													6	66					0	0	1	0	0
IFNA6	3443	broad.mit.edu	37	9	21350638	21350638	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:21350638C>T	ENST00000380210.1	-	1	739	c.249G>A	c.(247-249)gtG>gtA	p.V83V		NM_021002.2	NP_066282.1	P05013	IFNA6_HUMAN	interferon, alpha 6	83					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			large_intestine(3)|lung(7)|skin(1)	11				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TCTGCTGAATCACCTCATGGA	0.483000													42	80					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86189173	86189173	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:86189173C>T	ENST00000394518.2	+	10	4457	c.4362C>T	c.(4360-4362)atC>atT	p.I1454I	AKAP13_ENST00000361243.2_Silent_p.I1454I|AKAP13_ENST00000560579.1_3'UTR|RP11-815J21.4_ENST00000558980.1_RNA	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1454					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TGGACAGCATCATCTTCCCAA	0.453000													4	114					0	0	1	0	0
MEPE	56955	broad.mit.edu	37	4	88766913	88766913	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:88766913C>G	ENST00000497649.2	+	6	1199	c.821C>G	c.(820-822)aCa>aGa	p.T274R	MEPE_ENST00000540395.1_Missense_Mutation_p.T185R|MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000424957.3_Missense_Mutation_p.T298R|MEPE_ENST00000395102.4_Missense_Mutation_p.T329R|MEPE_ENST00000361056.3_Missense_Mutation_p.T298R|MEPE_ENST00000560249.1_Missense_Mutation_p.T185R			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	298					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		CATCTTGACACAAAAAAGCCA	0.438000													10	31					0	0	1	0	0
CSE1L	1434	broad.mit.edu	37	20	47691370	47691370	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:47691370G>A	ENST00000262982.2	+	11	1238	c.1115G>A	c.(1114-1116)aGa>aAa	p.R372K	CSE1L_ENST00000396192.3_Missense_Mutation_p.R316K|CSE1L_ENST00000542325.1_Missense_Mutation_p.R155K	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	372					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity	p.R372T(1)		breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TACATAAGGAGAGATTTGGAA	0.388000													6	57					0	0	1	0	0
SLC25A34	284723	broad.mit.edu	37	1	16064426	16064426	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:16064426C>T	ENST00000294454.5	+	2	462	c.381C>T	c.(379-381)atC>atT	p.I127I	SLC25A34_ENST00000489568.1_3'UTR	NM_207348.1	NP_997231.1	Q6PIV7	S2534_HUMAN	solute carrier family 25, member 34	127					transport	integral to membrane|mitochondrial inner membrane				NS(1)|breast(1)|endometrium(3)|large_intestine(1)|lung(2)|skin(1)	9		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCATAGATCAAAACGCAGC	0.642000													7	42					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81536974	81536974	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:81536974C>T	ENST00000548058.1	+	5	1779	c.869C>T	c.(868-870)tCa>tTa	p.S290L	ACSS3_ENST00000261206.3_Missense_Mutation_p.S289L			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	290						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						CCTGTTCTTTCAGAACACCCA	0.453000													27	47					0	0	1	0	0
SLC39A2	29986	broad.mit.edu	37	14	21469191	21469191	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:21469191C>T	ENST00000298681.4	+	4	540	c.383C>T	c.(382-384)cCt>cTt	p.P128L	SLC39A2_ENST00000554422.1_3'UTR	NM_014579.3	NP_055394.2	Q9NP94	S39A2_HUMAN	solute carrier family 39 (zinc transporter), member 2	128						cytoplasmic membrane-bounded vesicle|integral to plasma membrane	zinc ion transmembrane transporter activity			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	14	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0187)		CAGTGCTGTCCTGGGGCTGCT	0.507000													18	119					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41153994	41153994	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:41153994A>G	ENST00000263413.3	-	15	2472	c.2208T>C	c.(2206-2208)ttT>ttC	p.F736F	C6_ENST00000337836.5_Silent_p.F736F	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	736	C5b-binding domain.|Sushi 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CAGCAACAACAAAGCCTTTGG	0.468000													7	80					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39823288	39823288	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:39823288T>G	ENST00000564288.1	+	45	12443	c.11666T>G	c.(11665-11667)tTt>tGt	p.F3889C	MACF1_ENST00000289893.4_Missense_Mutation_p.F2329C|MACF1_ENST00000539005.1_Missense_Mutation_p.F1827C|MACF1_ENST00000545844.1_Missense_Mutation_p.F1827C|MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000372915.3_Missense_Mutation_p.F3894C|MACF1_ENST00000567887.1_Missense_Mutation_p.F3926C|MACF1_ENST00000361689.2_Missense_Mutation_p.F1827C|MACF1_ENST00000317713.7_Missense_Mutation_p.F1827C			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	3894					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CATAAAGAGTTTGAAAGCTGG	0.512000													5	87					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55568601	55568601	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:55568601C>T	ENST00000395445.1	-	36	5603	c.5209G>A	c.(5209-5211)Gaa>Aaa	p.E1737K	PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000395442.1_Missense_Mutation_p.E602K|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395446.1_Missense_Mutation_p.E933K|PCDH15_ENST00000395440.1_Missense_Mutation_p.E671K	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GATTCTGATTCCTCCTCACTT	0.502000										HNSCC(58;0.16)			4	10					0	0	1	0	0
FUT5	2527	broad.mit.edu	37	19	5866713	5866713	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:5866713G>A	ENST00000252675.5	-	5	1586	c.1024C>T	c.(1024-1026)Cgc>Tgc	p.R342C	FUT5_ENST00000588525.1_Missense_Mutation_p.R342C			Q11128	FUT5_HUMAN	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	342					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12						CTGAAGGAGCGAGGCCGCAGC	0.632000													6	31					0	0	1	0	0
MSH6	2956	broad.mit.edu	37	2	48018162	48018162	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:48018162C>T	ENST00000234420.5	+	2	509	c.357C>T	c.(355-357)ttC>ttT	p.F119F	MSH6_ENST00000538136.1_5'UTR|MSH6_ENST00000540021.1_Intron|FBXO11_ENST00000405808.1_Intron	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6		PWWP.				determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ATGGAACATTCATCCGCGAGA	0.478000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				7	101					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30339384	30339384	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:30339384C>T	ENST00000389194.2	-	10	1572	c.1567G>A	c.(1567-1569)Gaa>Aaa	p.E523K	LTN1_ENST00000361371.5_Missense_Mutation_p.E477K|LTN1_ENST00000389195.2_Missense_Mutation_p.E523K	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	477							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						GCTGTTTTTTCATCTTTTTCC	0.433000													21	182					0	0	1	0	0
SPINT1	6692	broad.mit.edu	37	15	41146090	41146090	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:41146090G>A	ENST00000344051.4	+	5	1158	c.924G>A	c.(922-924)ttG>ttA	p.L308L	SPINT1_ENST00000431806.1_Intron|SPINT1_ENST00000562057.1_Intron			O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	308						extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	16		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GTGGGCCTTTGAGAGGCAGCT	0.592000													20	62					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29884965	29884965	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:29884965G>C	ENST00000310624.6	+	4	1369	c.1336G>C	c.(1336-1338)Gtg>Ctg	p.V446L		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	446	Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						GAAGATCAAAGTGGTGGAGAA	0.468000													11	36					0	0	1	0	0
DEFB124	245937	broad.mit.edu	37	20	30053434	30053434	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:30053434G>A	ENST00000317676.2	-	2	90	c.91C>T	c.(91-93)Caa>Taa	p.Q31*		NM_001037500.1	NP_001032589.1	Q8NES8	DB124_HUMAN	defensin, beta 124	31					defense response to bacterium	extracellular region						Lung NSC(7;0.000139)|all_lung(7;0.000197)|all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CAGGCCCCTTGACCCTTCCAG	0.527000													17	61					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21627229	21627229	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:21627229G>A	ENST00000425654.2	+	19	2576	c.2096G>A	c.(2095-2097)cGa>cAa	p.R699Q	CNKSR2_ENST00000279451.4_Missense_Mutation_p.R729Q|CNKSR2_ENST00000379510.3_Missense_Mutation_p.R729Q|CNKSR2_ENST00000543067.1_Missense_Mutation_p.R680Q	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	729					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						AAACATAGCCGACTTTCCTCC	0.502000													5	24					0	0	1	0	0
HECTD3	79654	broad.mit.edu	37	1	45476220	45476220	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:45476220G>A	ENST00000372172.4	-	2	599	c.528C>T	c.(526-528)ctC>ctT	p.L176L		NM_024602.5	NP_078878.3	Q5T447	HECD3_HUMAN	HECT domain containing E3 ubiquitin protein ligase 3	176					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|stomach(1)	28	Acute lymphoblastic leukemia(166;0.155)					TGCAGTACCTGAGCACCGGCC	0.672000													9	30					0	0	1	0	0
TSPYL4	23270	broad.mit.edu	37	6	116575108	116575108	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:116575108C>T	ENST00000420283.1	-	1	153	c.64G>A	c.(64-66)Gac>Aac	p.D22N		NM_021648.4	NP_067680.3	Q9UJ04	TSYL4_HUMAN	TSPY-like 4	22					nucleosome assembly	nucleus				endometrium(2)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(2)	11		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.045)|OV - Ovarian serous cystadenocarcinoma(136;0.0666)|GBM - Glioblastoma multiforme(226;0.095)|Epithelial(106;0.125)		GAGGCATGGTCGGGAGCAGCC	0.627000													3	17					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879168	3879168	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:3879168G>A	ENST00000315677.3	-	4	1496	c.901C>T	c.(901-903)Cag>Tag	p.Q301*	DLGAP1_ENST00000584874.1_Nonsense_Mutation_p.Q301*|DLGAP1_ENST00000581527.1_Nonsense_Mutation_p.Q301*|DLGAP1_ENST00000515196.2_Nonsense_Mutation_p.Q301*|DLGAP1-AS3_ENST00000577649.1_RNA	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	301					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				ACCATGGCCTGGTCCATGTTC	0.597000													7	57					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685289	248685289	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:248685289C>T	ENST00000343414.4	+	1	374	c.342C>T	c.(340-342)ctC>ctT	p.L114L		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGTGTATTCTCTTGGCCGTCA	0.557000													13	49					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64974243	64974243	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:64974243C>T	ENST00000399262.2	-	8	1902	c.1684G>A	c.(1684-1686)Gac>Aac	p.D562N	JMJD1C_ENST00000399251.1_Missense_Mutation_p.D343N|JMJD1C_ENST00000542921.1_Missense_Mutation_p.D380N|JMJD1C_ENST00000402544.1_Missense_Mutation_p.D343N	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	562					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					CAGCTCTGGTCAGAATCTTTT	0.368000													12	65					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47125625	47125625	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:47125625T>C	ENST00000409792.3	-	12	5687	c.5645A>G	c.(5644-5646)aAa>aGa	p.K1882R		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1882					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ACTTATAATTTTCAGTCTGCG	0.443000			"""N, F, S, Mis"""		clear cell renal carcinoma								17	184					0	0	1	0	0
PRMT6	55170	broad.mit.edu	37	1	107600312	107600312	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:107600312G>A	ENST00000361318.5	+	1	1046	c.798G>A	c.(796-798)ctG>ctA	p.L266L	PRMT6_ENST00000370078.1_Silent_p.L325L	NM_018137.2	NP_060607.2	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	325					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			biliary_tract(1)|breast(2)|kidney(1)|large_intestine(4)|lung(5)|urinary_tract(1)	14		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		TCCTCTACCTGAACGAGCCGG	0.642000													5	32					0	0	1	0	0
ZNF785	146540	broad.mit.edu	37	16	30594761	30594761	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:30594761G>C	ENST00000395216.2	-	3	497	c.338C>G	c.(337-339)tCc>tGc	p.S113C	ZNF785_ENST00000470110.1_Missense_Mutation_p.S98C|AC002310.7_ENST00000492040.1_RNA	NM_152458.6	NP_689671.2	A8K8V0	ZN785_HUMAN	zinc finger protein 785	113					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9						CCCATCCCTGGATCCTGAAAC	0.493000													8	50					0	0	1	0	0
CDK8	1024	broad.mit.edu	37	13	26923311	26923311	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:26923311G>A	ENST00000381527.3	+	3	810	c.307G>A	c.(307-309)Gac>Aac	p.D103N	CDK8_ENST00000536792.1_Missense_Mutation_p.D103N	NM_001260.1	NP_001251.1	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	103	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity	p.D103N(1)		breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	25	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		TGCTGAACATGACCTCTGGGT	0.413000													26	78					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111019635	111019635	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:111019635G>A	ENST00000262839.2	-	11	3746	c.2828C>T	c.(2827-2829)tCa>tTa	p.S943L		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	943					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TACATCCTCTGAGGAGTCTAA	0.488000													10	13					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144882665	144882665	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:144882665G>A	ENST00000369359.4	-	27	3803	c.3765C>T	c.(3763-3765)ctC>ctT	p.L1255L	PDE4DIP_ENST00000369354.3_Silent_p.L1118L|PDE4DIP_ENST00000530740.1_Silent_p.L1255L|PDE4DIP_ENST00000369356.4_Silent_p.L1118L|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000313382.9_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1118					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GTTCTTTGAGGAGGTTGATGA	0.453000			T	PDGFRB	MPD								43	448					0	0	1	0	0
ZNF256	10172	broad.mit.edu	37	19	58453920	58453920	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:58453920G>C	ENST00000282308.3	-	3	452	c.256C>G	c.(256-258)Ccc>Gcc	p.P86A	ZNF256_ENST00000598928.1_Silent_p.L43L	NM_005773.2	NP_005764.2	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	86	KRAB.				multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		GTCTTCTGGGGAGAAGGAAGG	0.517000													21	113					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84485627	84485627	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:84485627G>A	ENST00000416219.2	+	18	1850	c.1761G>A	c.(1759-1761)caG>caA	p.Q587Q	ATP2C2_ENST00000262429.4_Silent_p.Q587Q|ATP2C2_ENST00000420010.2_3'UTR			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	587					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						AAGCAGTCCAGGTTCTCTCCG	0.622000													4	43					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167284396	167284396	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:167284396T>G	ENST00000409855.1	-	17	2881	c.2755A>C	c.(2755-2757)Atc>Ctc	p.I919L		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	919					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						TTCTGCCAGATTTTTCCTTTC	0.418000													9	30					0	0	1	0	0
THBD	7056	broad.mit.edu	37	20	23029163	23029163	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:23029163C>T	ENST00000377103.2	-	1	1215	c.979G>A	c.(979-981)Gat>Aat	p.D327N		NM_000361.2	NP_000352.1	P07204	TRBM_HUMAN	thrombomodulin	327	EGF-like 3; calcium-binding (Potential).				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity			endometrium(2)|large_intestine(3)|ovary(1)|skin(1)	7	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	ATGCAGTCATCCACGTCCTCG	0.647000													7	14					0	0	1	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28282294	28282294	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:28282294C>T	ENST00000373894.3	+	6	981	c.790C>T	c.(790-792)Cgg>Tgg	p.R264W	SMPDL3B_ENST00000373888.4_Missense_Mutation_p.R264W|SMPDL3B_ENST00000549094.1_Missense_Mutation_p.R216W|RP11-460I13.2_ENST00000448015.1_RNA	NM_014474.2	NP_055289.2	Q92485	ASM3B_HUMAN	sphingomyelin phosphodiesterase, acid-like 3B	264					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	16		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		GAAGGTGGTCCGGAAGCATCA	0.547000													7	70					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126240797	126240797	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:126240797G>A	ENST00000394329.3	+	1	3244	c.3231G>A	c.(3229-3231)gtG>gtA	p.V1077V		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1077	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ACAGAGCAGTGGAACCCCTTA	0.358000													40	85					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91690682	91690682	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:91690682C>T	ENST00000359028.2	+	24	5971	c.5746C>T	c.(5746-5748)Cat>Tat	p.H1916Y	AKAP9_ENST00000358100.2_Missense_Mutation_p.H1916Y|AKAP9_ENST00000491695.1_3'UTR|AKAP9_ENST00000356239.3_Missense_Mutation_p.H1904Y			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1916	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGAGCGCCTTCATGAGGAGTC	0.483000			T	BRAF	papillary thyroid								12	31					0	0	1	0	0
DHX35	60625	broad.mit.edu	37	20	37632410	37632410	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:37632410G>T	ENST00000252011.3	+	11	904	c.871G>T	c.(871-873)Gtg>Ttg	p.V291L	DHX35_ENST00000373323.4_Missense_Mutation_p.V260L|DHX35_ENST00000373325.2_Missense_Mutation_p.V291L	NM_021931.3	NP_068750.2	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	291	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	40		Myeloproliferative disorder(115;0.00878)				AGAAACTGTTGTGTCGATGCT	0.448000													19	84					8.00594e-06	8.22075e-06	1	1	0
VANGL2	57216	broad.mit.edu	37	1	160388872	160388872	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:160388872C>T	ENST00000368061.2	+	4	747	c.273C>T	c.(271-273)atC>atT	p.I91I		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	91					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCACACGCATCGCCAAGGACA	0.617000													20	56					0	0	1	0	0
ETS2	2114	broad.mit.edu	37	21	40194793	40194793	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:40194793C>T	ENST00000360214.3	+	11	1850	c.1390C>T	c.(1390-1392)Cag>Tag	p.Q464*	ETS2_ENST00000360938.3_Nonsense_Mutation_p.Q464*	NM_001256295.1	NP_001243224.1	P15036	ETS2_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 2	464					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				CCTGGGCGTCCAGCCCGACAC	0.672000													4	24					0	0	1	0	0
FAM122C	159091	broad.mit.edu	37	X	133941727	133941727	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:133941727C>T	ENST00000414371.2	+	3	380	c.207C>T	c.(205-207)atC>atT	p.I69I	FAM122C_ENST00000445123.1_5'UTR|FAM122C_ENST00000370785.3_Silent_p.I33I|FAM122C_ENST00000475361.1_3'UTR|FAM122C_ENST00000370784.4_Silent_p.I33I	NM_001170780.1|NM_001170784.1	NP_001164251.1|NP_001164255.1	Q6P4D5	F222C_HUMAN	family with sequence similarity 122C	33										endometrium(2)|kidney(1)|lung(2)	5	Acute lymphoblastic leukemia(192;0.000127)					CCCCTTTGATCAATGGACTTG	0.507000													15	28					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103185709	103185709	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:103185709C>T	ENST00000428762.1	-	42	6544	c.6385G>A	c.(6385-6387)Ggt>Agt	p.G2129S	RELN_ENST00000343529.5_Missense_Mutation_p.G2129S|RELN_ENST00000424685.2_Missense_Mutation_p.G2129S	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2129	EGF-like 5.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CACTGGGGACCGATGTAGACA	0.483000													5	48					0	0	1	0	0
C3orf70	285382	broad.mit.edu	37	3	184870559	184870559	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:184870559A>C	ENST00000335012.2	-	1	243	c.53T>G	c.(52-54)cTa>cGa	p.L18R		NM_001025266.1	NP_001020437.1	A6NLC5	CC070_HUMAN	chromosome 3 open reading frame 70	18										breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|urinary_tract(1)	13						AGCCTCATCTAGTTTCTCGCT	0.692000													5	30					0	0	1	0	0
CLCN7	1186	broad.mit.edu	37	16	1510488	1510488	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:1510488G>A	ENST00000382745.4	-	6	1130	c.525C>T	c.(523-525)tcC>tcT	p.S175S	CLCN7_ENST00000448525.1_Silent_p.S151S|CLCN7_ENST00000262318.8_Silent_p.S151S	NM_001287.5	NP_001278.1	P51798	CLCN7_HUMAN	chloride channel, voltage-sensitive 7	175						integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	24		Hepatocellular(780;0.0893)				ACAGCAACAGGGAGAAGGACA	0.607000													9	25					0	0	1	0	0
NCOA5	57727	broad.mit.edu	37	20	44695813	44695813	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:44695813C>T	ENST00000290231.6	-	5	674	c.510G>A	c.(508-510)ttG>ttA	p.L170L		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				CCTCACGTTTCAAACGCTCTG	0.433000													13	79					0	0	1	0	0
LOX	4015	broad.mit.edu	37	5	121411186	121411186	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:121411186C>T	ENST00000231004.4	-	3	1090	c.791G>A	c.(790-792)aGa>aAa	p.R264K	SRFBP1_ENST00000504881.1_3'UTR|LOX_ENST00000513319.1_5'UTR	NM_001178102.1|NM_002317.5	NP_001171573.1|NP_002308.2	P28300	LYOX_HUMAN	lysyl oxidase	264	Lysyl-oxidase like.				protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			endometrium(1)|lung(6)|prostate(1)	8		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		TTGGGGAAATCTGAGCAGCAC	0.388000													26	33					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42478050	42478050	+	Silent	SNP	C	C	T	rs148971311	byFrequency	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:42478050C>T	ENST00000434000.1	-	9	1443	c.1161G>A	c.(1159-1161)ccG>ccA	p.P387P	GPATCH8_ENST00000591680.1_Silent_p.P465P			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	465						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TGGTTTCCTTCGGCTGCTCAG	0.493000											OREG0024461	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	210					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29111072	29111072	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:29111072G>A	ENST00000261590.8	+	9	1346	c.1137G>A	c.(1135-1137)gtG>gtA	p.V379V		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	379	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGGTCAAAGTGAAAAATGTGA	0.368000													27	72					0	0	1	0	0
PLXDC1	57125	broad.mit.edu	37	17	37234283	37234283	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:37234283C>T	ENST00000315392.4	-	11	1280	c.1069G>A	c.(1069-1071)Gag>Aag	p.E357K	PLXDC1_ENST00000539608.1_3'UTR|CTD-2206N4.4_ENST00000583447.1_RNA|PLXDC1_ENST00000444911.2_Missense_Mutation_p.E317K|PLXDC1_ENST00000493200.1_5'UTR	NM_020405.4	NP_065138.2	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1	357					angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						TGGAAGTCCTCGCACATCCTG	0.542000													4	35					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135145065	135145065	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:135145065C>T	ENST00000372169.2	-	25	7406	c.7224G>A	c.(7222-7224)ttG>ttA	p.L2408L	SETX_ENST00000477049.1_5'UTR|SETX_ENST00000393220.1_Silent_p.L2375L|SETX_ENST00000224140.5_Silent_p.L2408L			Q7Z333	SETX_HUMAN	senataxin	2408					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TGGTGACATTCAATCTCTGCA	0.443000													15	153					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216496877	216496877	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:216496877C>T	ENST00000366943.2	-	8	1875	c.1489G>A	c.(1489-1491)Gag>Aag	p.E497K	USH2A_ENST00000307340.3_Missense_Mutation_p.E497K|USH2A_ENST00000366942.3_Missense_Mutation_p.E497K			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	497	Laminin N-terminal.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACAGCAGTCTCAGTTGTATAG	0.373000										HNSCC(13;0.011)			15	88					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50682351	50682351	+	Nonsense_Mutation	SNP	G	G	A	rs143957857	by1000genomes	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:50682351G>A	ENST00000439308.2	-	1	1030	c.538C>T	c.(538-540)Cag>Tag	p.Q180*	TUBGCP6_ENST00000248846.5_Nonsense_Mutation_p.Q180*	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	180					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCCATAACCTGAAGTGTTTCC	0.547000													5	31					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100887671	100887671	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:100887671C>T	ENST00000358544.2	+	62	11957	c.11846C>T	c.(11845-11847)tCa>tTa	p.S3949L	VPS13B_ENST00000357162.2_Missense_Mutation_p.S3924L|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3949					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GAGAGACTGTCAGAGCAACAG	0.458000													26	391					0	0	1	0	0
KLHDC3	116138	broad.mit.edu	37	6	42986270	42986270	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:42986270G>A	ENST00000326974.4	+	6	904	c.709G>A	c.(709-711)Gag>Aag	p.E237K	KLHDC3_ENST00000332245.8_Missense_Mutation_p.E178K|KLHDC3_ENST00000244670.8_Missense_Mutation_p.E103K	NM_057161.3	NP_476502.1	Q9BQ90	KLDC3_HUMAN	kelch domain containing 3	237					reciprocal meiotic recombination	cytoplasm|nuclear chromatin	chromatin binding|protein binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			AGTGCTGCCTGAGGGGCGCCG	0.562000													36	95					0	0	1	0	0
HCAR1	27198	broad.mit.edu	37	12	123214089	123214089	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:123214089G>A	ENST00000432564.1	-	1	1040	c.798C>T	c.(796-798)ttC>ttT	p.F266F	HCAR1_ENST00000356987.2_Silent_p.F266F|HCAR1_ENST00000436083.2_Silent_p.F266F	NM_032554.3	NP_115943.1	Q9BXC0	HCAR1_HUMAN	hydroxycarboxylic acid receptor 1	266					response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)	10						TCATGTAGGTGAAGCTGAGGG	0.522000													7	107					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48739356	48739356	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:48739356C>T	ENST00000314191.2	-	64	8697	c.8641G>A	c.(8641-8643)Gcc>Acc	p.A2881T	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.A2881T	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2882	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGTAGGCTGGCCAGGCAACCA	0.637000								Non-homologous end-joining					4	11					0	0	1	0	0
SLC25A33	84275	broad.mit.edu	37	1	9613837	9613837	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:9613837G>A	ENST00000302692.6	+	2	420	c.210G>A	c.(208-210)gtG>gtA	p.V70V		NM_032315.2	NP_115691.1	Q9BSK2	S2533_HUMAN	solute carrier family 25 (pyrimidine nucleotide carrier), member 33	70					transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|kidney(1)|lung(4)|prostate(1)|skin(1)	9	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)		CAACATCCGTGACACCTGGAC	0.507000													4	32					0	0	1	0	0
PGBD4	161779	broad.mit.edu	37	15	34394951	34394951	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:34394951G>A	ENST00000397766.2	+	1	678	c.219G>A	c.(217-219)atG>atA	p.M73I		NM_152595.4	NP_689808.2	Q96DM1	PGBD4_HUMAN	piggyBac transposable element derived 4	73										breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|pancreas(1)|prostate(1)	16		all_lung(180;1.76e-08)		all cancers(64;1.22e-17)|GBM - Glioblastoma multiforme(113;1.78e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0242)		GGCGCTCCATGAAATGGTCAG	0.463000													9	39					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50377209	50377209	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:50377209C>T	ENST00000376020.2	-	4	1889	c.1864G>A	c.(1864-1866)Gag>Aag	p.E622K	SHROOM4_ENST00000289292.7_Missense_Mutation_p.E622K|SHROOM4_ENST00000460112.3_Missense_Mutation_p.E506K	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	622					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					TCCTGGGTCTCTTCCACTGGC	0.507000													3	17					0	0	1	0	0
ATP5B	506	broad.mit.edu	37	12	57037645	57037645	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:57037645G>A	ENST00000262030.3	-	4	633	c.583C>T	c.(583-585)Ccc>Tcc	p.P195S	ATP5B_ENST00000552919.1_Missense_Mutation_p.P195S	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	195					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TTGGCATAGGGAGCTAGCAGA	0.418000													17	75					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119044627	119044627	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:119044627G>A	ENST00000409109.1	+	5	1256	c.669G>A	c.(667-669)ctG>ctA	p.L223L	NLRX1_ENST00000525863.1_Silent_p.L223L|NLRX1_ENST00000292199.2_Silent_p.L223L|NLRX1_ENST00000409991.1_Silent_p.L223L|NLRX1_ENST00000409265.4_Silent_p.L223L	NM_001282144.1	NP_001269073.1	Q86UT6	NLRX1_HUMAN	NLR family member X1	223	NACHT.|Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		ACACGCCCCTGAAGGAGGTTC	0.637000													8	32					0	0	1	0	0
RANBP17	64901	broad.mit.edu	37	5	170722905	170722905	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:170722905G>A	ENST00000523189.1	+	27	3221	c.3057G>A	c.(3055-3057)ctG>ctA	p.L1019L	RANBP17_ENST00000521759.1_3'UTR	NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	1019					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCAGTGAACTGAGAGCAAGTT	0.532000			T	TRD@	ALL								10	47					0	0	1	0	0
RP11-337C18.8	0	broad.mit.edu	37	1	146650109	146650109	+	RNA	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:146650109C>T	ENST00000607149.1	+	0	350				RP11-337C18.8_ENST00000606757.1_RNA|RP11-337C18.10_ENST00000606856.1_RNA																							CAGTGCCTCTCAGGACTGAGG	0.443000													24	102					0	0	1	0	0
GGA2	23062	broad.mit.edu	37	16	23481470	23481470	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:23481470G>A	ENST00000309859.4	-	15	1549	c.1467C>T	c.(1465-1467)ctC>ctT	p.L489L	GGA2_ENST00000567468.1_Intron	NM_015044.4	NP_055859.1	Q9UJY4	GGA2_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	489	GAE.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(48;0.0386)		CATACACAATGAGAGGCGGCA	0.537000													3	36					0	0	1	0	0
FUCA1	2517	broad.mit.edu	37	1	24194664	24194664	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:24194664G>A	ENST00000374479.3	-	1	120	c.113C>T	c.(112-114)aCc>aTc	p.T38I		NM_000147.4	NP_000138.2	P04066	FUCO_HUMAN	fucosidase, alpha-L- 1, tissue	38					fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		CCAGTCTGGGGTGTAGCGGCG	0.716000													4	11					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33335759	33335759	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:33335759C>T	ENST00000404816.2	+	4	1327	c.974C>T	c.(973-975)tCc>tTc	p.S325F	LTBP1_ENST00000354476.3_Missense_Mutation_p.S325F			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	325					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GGAGAGCAGTCCACTGAAGGT	0.473000													21	71					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37360556	37360556	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:37360556A>C	ENST00000361924.2	+	12	1790	c.1416A>C	c.(1414-1416)aaA>aaC	p.K472N	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000435830.2_3'UTR|GOLGA4_ENST00000356847.4_Missense_Mutation_p.K494N	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	472	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						ATTTTCAGAAATCCTCAGAAG	0.358000													6	119					0	0	1	0	0
SYT8	90019	broad.mit.edu	37	11	1858238	1858238	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:1858238G>A	ENST00000341958.3	+	7	1144	c.842G>A	c.(841-843)aGa>aAa	p.R281K	SYT8_ENST00000535046.1_3'UTR|SYT8_ENST00000381968.3_Missense_Mutation_p.R295K			Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	295	C2 2.					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			breast(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	6		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGGAAGAAGAGAAAGACAGCC	0.627000													9	39					0	0	1	0	0
LINC00957	255031	broad.mit.edu	37	7	44080628	44080628	+	RNA	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:44080628C>T	ENST00000441052.1	+	0	1313																											TACTTCTCCTCAAACACCTTG	0.642000													6	54					0	0	1	0	0
CCP110	9738	broad.mit.edu	37	16	19547277	19547277	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:19547277A>G	ENST00000396212.2	+	5	722	c.286A>G	c.(286-288)Aat>Gat	p.N96D	CCP110_ENST00000396208.2_Missense_Mutation_p.N96D|CCP110_ENST00000381396.5_Missense_Mutation_p.N96D	NM_014711.4	NP_055526	O43303	CP110_HUMAN	centriolar coiled coil protein 110kDa	96	CEP97 binding.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|stomach(3)|urinary_tract(1)	21						AAAAGCACCTAATGCCAGTGA	0.318000													8	48					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179396658	179396658	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:179396658G>A	ENST00000589042.1	-	358	104908	c.104684C>T	c.(104683-104685)tCa>tTa	p.S34895L	TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S26022L|TTN_ENST00000591111.1_Missense_Mutation_p.S33254L|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.S32327L|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S25955L|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S25830L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	33254							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCGAGAGTGATCTCTCACT	0.463000													5	24					0	0	1	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69337205	69337205	+	Silent	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:69337205T>C	ENST00000305363.4	+	5	418	c.354T>C	c.(352-354)caT>caC	p.H118H		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	118	SEA.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						TGTTGGCTCATATGCTGTTGA	0.393000													16	315					0	0	1	0	0
HLA-DOB	3112	broad.mit.edu	37	6	32780996	32780996	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:32780996G>C	ENST00000438763.2	-	6	915	c.819C>G	c.(817-819)tgC>tgG	p.C273W		NM_002120.3	NP_002111.1			major histocompatibility complex, class II, DO beta											endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	9						GAGGACCTTAGCATGACTGAG	0.547000													4	46					0	0	1	0	0
LIPI	149998	broad.mit.edu	37	21	15561505	15561505	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:15561505C>G	ENST00000344577.2	-	2	370	c.345G>C	c.(343-345)caG>caC	p.Q115H	LIPI_ENST00000536861.1_Missense_Mutation_p.Q94H	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	94					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTACGAAGTTCTGAAGCCATA	0.358000													34	62					0	0	1	0	0
LMAN2	10960	broad.mit.edu	37	5	176778247	176778247	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:176778247G>A	ENST00000303127.7	-	2	446	c.242C>T	c.(241-243)aCt>aTt	p.T81I	LMAN2_ENST00000506310.1_5'UTR|LMAN2_ENST00000515209.1_Missense_Mutation_p.T81I	NM_006816.2	NP_006807.1	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2	81	L-type lectin-like.				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGTGAGCATAGTGCTGCCCTG	0.602000													18	39					0	0	1	0	0
RASSF6	166824	broad.mit.edu	37	4	74442170	74442170	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:74442170A>G	ENST00000307439.5	-	10	1189	c.895T>C	c.(895-897)Tta>Cta	p.L299L	RASSF6_ENST00000395777.2_Silent_p.L265L|RASSF6_ENST00000335049.5_Silent_p.L287L|RASSF6_ENST00000342081.3_Silent_p.L331L	NM_001270391.1|NM_177532.4	NP_001257320.1|NP_803876.1	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family member 6	331	Ras-associating.				apoptosis|signal transduction		protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|pancreas(2)|skin(2)	17	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			TCTTCATTTAATCTTTGAAGA	0.323000													8	45					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68688050	68688050	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:68688050G>A	ENST00000361320.4	+	2	1954	c.1376G>A	c.(1375-1377)cGa>cAa	p.R459Q	CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.2_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	459						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TCCCTCATGCGAAGGCACAGG	0.522000													15	56					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89854845	89854845	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:89854845C>T	ENST00000287908.3	+	2	842	c.449C>T	c.(448-450)tCa>tTa	p.S150L	STEAP2_ENST00000394626.1_Missense_Mutation_p.S150L|STEAP2_ENST00000402625.2_Missense_Mutation_p.S150L|STEAP2_ENST00000394632.1_Missense_Mutation_p.S150L|STEAP2_ENST00000394629.2_Missense_Mutation_p.S150L|STEAP2_ENST00000394621.2_Missense_Mutation_p.S150L|STEAP2_ENST00000394622.2_Missense_Mutation_p.S150L	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	150					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					AATGTTGTCTCAGCTTGGGCA	0.363000													27	92					0	0	1	0	0
PGP	283871	broad.mit.edu	37	16	2263945	2263945	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:2263945G>A	ENST00000333503.7	-	2	779	c.750C>T	c.(748-750)atC>atT	p.I250I		NM_001042371.2	NP_001035830.1	A6NDG6	PGP_HUMAN	phosphoglycolate phosphatase	250					carbohydrate metabolic process		phosphoglycolate phosphatase activity			skin(1)	1						GCTCGGGGTTGATGCCGTATT	0.642000													9	66					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151166224	151166224	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:151166224A>G	ENST00000282466.3	-	4	1544	c.1545T>C	c.(1543-1545)agT>agC	p.S515S		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	515	Ig-like C2-type 1.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTCTCACTTTACTTCCATCAG	0.502000													37	145					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32198981	32198981	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:32198981C>G	ENST00000492345.1	+	5	885	c.200C>G	c.(199-201)tCc>tGc	p.S67C	CBFA2T2_ENST00000346541.3_Missense_Mutation_p.S96C|CBFA2T2_ENST00000397798.2_Missense_Mutation_p.S67C|CBFA2T2_ENST00000397800.1_Missense_Mutation_p.S67C|CBFA2T2_ENST00000375279.2_Missense_Mutation_p.S96C|CBFA2T2_ENST00000342704.6_Missense_Mutation_p.S87C|CBFA2T2_ENST00000344201.3_Missense_Mutation_p.S67C|CBFA2T2_ENST00000359606.3_Missense_Mutation_p.S106C			O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	96	Pro-rich.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						GGTCCTGCCTCCTCCACATCA	0.483000													11	111					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52585445	52585445	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:52585445T>G	ENST00000313234.5	-	1	339	c.242A>C	c.(241-243)aAc>aCc	p.N81T	KRT80_ENST00000394815.2_Missense_Mutation_p.N81T	NM_001081492.1	NP_001074961.1	Q6KB66	K2C80_HUMAN	keratin 80	81	Head.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		CTTCTCCTGGTTCTTCAGCTG	0.572000													18	83					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16202986	16202986	+	Silent	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:16202986A>C	ENST00000375759.3	+	3	898	c.694A>C	c.(694-696)Agg>Cgg	p.R232R	SPEN_ENST00000471538.1_3'UTR	NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	232	Arg-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ACGAGGCAGAAGGCCAGAGCG	0.542000													17	61					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138978025	138978025	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:138978025C>T	ENST00000473989.3	+	16	3717	c.3717C>T	c.(3715-3717)ctC>ctT	p.L1239L	UBN2_ENST00000288561.8_Silent_p.L1156L	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2											NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						CTCTGACTCTCATGACATCAC	0.453000													9	61					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73564621	73564621	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:73564621G>C	ENST00000392550.3	+	11	1218	c.1101G>C	c.(1099-1101)caG>caC	p.Q367H	LLGL2_ENST00000577200.1_Missense_Mutation_p.Q367H|LLGL2_ENST00000167462.5_Missense_Mutation_p.Q367H	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	367					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			TTGACCTGCAGACAGCAGGCT	0.642000													6	25					0	0	1	0	0
CD200	4345	broad.mit.edu	37	3	112066563	112066563	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:112066563T>C	ENST00000315711.8	+	4	637	c.580T>C	c.(580-582)Tct>Cct	p.S194P	CD200_ENST00000473539.1_Missense_Mutation_p.S219P|CD200_ENST00000383681.3_Missense_Mutation_p.S120P	NM_005944.5	NP_005935.4	P41217	OX2G_HUMAN	CD200 molecule	194	Ig-like C2-type.				regulation of immune response	integral to plasma membrane				endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				TGGGACCACGTCTGTTACCAG	0.552000													9	73					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33545228	33545228	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:33545228C>T	ENST00000242067.6	+	20	2790	c.2269C>T	c.(2269-2271)Ctg>Ttg	p.L757L	BBS9_ENST00000350941.3_Silent_p.L717L|BBS9_ENST00000355070.2_Silent_p.L752L|BBS9_ENST00000396127.2_Silent_p.L722L|BBS9_ENST00000354265.4_Silent_p.L722L	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	757					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding	p.L757L(2)	BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			AGCGGCATTTCTGCCGCTACA	0.488000									Bardet-Biedl syndrome				6	54					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52827928	52827928	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:52827928C>T	ENST00000252245.5	-	1	381	c.161G>A	c.(160-162)gGg>gAg	p.G54E		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	54	Gly-rich.|Head.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		AAAGCTGGCCCCAGCACTGCT	0.667000													6	36					0	0	1	0	0
PHF11	51131	broad.mit.edu	37	13	50102652	50102652	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:50102652G>C	ENST00000357596.3	+	11	1006	c.730G>C	c.(730-732)Gag>Cag	p.E244Q	PHF11_ENST00000488958.1_Missense_Mutation_p.E244Q|PHF11_ENST00000378319.3_Missense_Mutation_p.E283Q	NM_001040444.1	NP_001035534.1	Q9UIL8	PHF11_HUMAN	PHD finger protein 11	283					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			large_intestine(3)|lung(1)	4		Lung NSC(96;2.1e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.38e-09)		CATAGCAATAGAGAAAAAAAT	0.333000													11	44					0	0	1	0	0
DUSP1	1843	broad.mit.edu	37	5	172196668	172196668	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:172196668C>T	ENST00000239223.3	-	3	885	c.643G>A	c.(643-645)Gag>Aag	p.E215K	RP11-779O18.3_ENST00000523005.1_RNA	NM_004417.3	NP_004408.1	P28562	DUS1_HUMAN	dual specificity phosphatase 1	215	Tyrosine-protein phosphatase.				cell cycle|endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding			NS(1)|breast(2)|endometrium(1)|large_intestine(1)|liver(1)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	10	Renal(175;0.000159)|Lung NSC(126;0.00431)|all_lung(126;0.00729)	all_hematologic(541;4.11e-18)|Breast(839;0.00637)|Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.15)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)	GBM - Glioblastoma multiforme(465;0.0103)		TAGTGACCCTCAAAATGGTTG	0.522000													17	69					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82581309	82581309	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:82581309A>T	ENST00000333891.9	-	5	9297	c.8960T>A	c.(8959-8961)aTt>aAt	p.I2987N	PCLO_ENST00000423517.2_Missense_Mutation_p.I2987N	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CATTCCCCCAATCCCTCTATA	0.418000													47	114					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19511656	19511656	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:19511656G>A	ENST00000375267.2	-	15	1878	c.1875C>T	c.(1873-1875)agC>agT	p.S625S	UBR4_ENST00000375254.3_Silent_p.S625S|UBR4_ENST00000375217.2_Silent_p.S625S|UBR4_ENST00000375226.2_Silent_p.S625S			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	625	Pro-rich.				interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCTTACTGGGGCTTTTAACCC	0.532000													31	157					0	0	1	0	0
TMEM171	134285	broad.mit.edu	37	5	72419270	72419270	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:72419270T>C	ENST00000454765.2	+	2	543	c.70T>C	c.(70-72)Tgc>Cgc	p.C24R	TMEM171_ENST00000287773.5_Missense_Mutation_p.C24R			Q8WVE6	TM171_HUMAN	transmembrane protein 171	24						integral to membrane				endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|stomach(1)	15		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		ACTCATCTTCTGCTTCTTTGT	0.587000													16	33					0	0	1	0	0
NOP58	51602	broad.mit.edu	37	2	203152401	203152401	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:203152401G>T	ENST00000264279.5	+	6	679	c.453G>T	c.(451-453)ttG>ttT	p.L151F		NM_015934.3	NP_057018.1	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein	151					cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(4)|prostate(2)	16						GATATAGATTGAAGTTTAGCG	0.348000													29	61					3.1745e-13	3.31741e-13	1	1	0
COPA	1314	broad.mit.edu	37	1	160268936	160268936	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:160268936C>A	ENST00000241704.7	-	18	2015	c.1786G>T	c.(1786-1788)Gag>Tag	p.E596*	COPA_ENST00000368069.3_Nonsense_Mutation_p.E605*	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	596					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AATTTGAACTCAGTGGGATCA	0.443000													34	64					1.42033e-22	1.49531e-22	1	1	0
DNAH10	196385	broad.mit.edu	37	12	124408909	124408909	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:124408909C>A	ENST00000409039.3	+	66	11367	c.11342C>A	c.(11341-11343)tCa>tAa	p.S3781*	CCDC92_ENST00000544798.1_Intron	NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3781					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATTCTTTTATCAGAAATGTTT	0.438000													7	32					0.0293803	0.0295473	1	1	0
XPO1	7514	broad.mit.edu	37	2	61712929	61712929	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:61712929C>T	ENST00000401558.2	-	20	3209	c.2482G>A	c.(2482-2484)Gaa>Aaa	p.E828K	XPO1_ENST00000406957.1_Missense_Mutation_p.E828K|XPO1_ENST00000404992.2_Missense_Mutation_p.E828K	NM_003400.3	NP_003391.1	O14980	XPO1_HUMAN	exportin 1 (CRM1 homolog, yeast)	828					intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(5)|lung(5)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			AATGTGCATTCAAAAACAGCA	0.348000			Mis		CLL								7	69					0	0	1	0	0
FAM219B	57184	broad.mit.edu	37	15	75195039	75195039	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:75195039G>A	ENST00000357635.5	-	5	838	c.518C>T	c.(517-519)cCc>cTc	p.P173L	FAM219B_ENST00000565772.1_Missense_Mutation_p.P87L|FAM219B_ENST00000563119.1_Missense_Mutation_p.P173L	NM_020447.3	NP_065180.1	Q5XKK7	CO017_HUMAN	family with sequence similarity 219, member B	173							cytochrome-c oxidase activity										GGGCTTAGGGGGGATGAGGTC	0.557000													17	80					0	0	1	0	0
DNAJC6	9829	broad.mit.edu	37	1	65849994	65849994	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:65849994C>A	ENST00000395325.3	+	6	771	c.614C>A	c.(613-615)tCa>tAa	p.S205*	DNAJC6_ENST00000263441.7_Nonsense_Mutation_p.S192*|DNAJC6_ENST00000498720.1_3'UTR|DNAJC6_ENST00000371069.4_Nonsense_Mutation_p.S262*	NM_014787.3	NP_055602.1	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	205	Phosphatase tensin-type.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(22)|ovary(1)|prostate(2)|skin(1)	39						ATTGGACTTTCACCATCCCAT	0.418000													9	34					7.48243e-07	7.72239e-07	1	1	0
PDZD2	23037	broad.mit.edu	37	5	32090187	32090187	+	Silent	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:32090187T>C	ENST00000438447.1	+	20	7021	c.6633T>C	c.(6631-6633)caT>caC	p.H2211H	PDZD2_ENST00000282493.3_Silent_p.H2211H			O15018	PDZD2_HUMAN	PDZ domain containing 2	2211					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GGGAGGACCATCTCTACTTCA	0.597000													40	167					0	0	1	0	0
MCCC2	64087	broad.mit.edu	37	5	70892167	70892167	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:70892167G>A	ENST00000340941.6	+	3	386	c.257G>A	c.(256-258)aGa>aAa	p.R86K	MCCC2_ENST00000509358.2_Missense_Mutation_p.R86K|MCCC2_ENST00000323375.8_Missense_Mutation_p.R86K	NM_022132.4	NP_071415.1	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-CoA carboxylase 2 (beta)	86	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			endometrium(2)|kidney(15)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	30		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	CCCAGAGAAAGAATTGACAAT	0.403000													6	42					0	0	1	0	0
ADNP	23394	broad.mit.edu	37	20	49518595	49518595	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:49518595C>T	ENST00000396029.3	-	4	727	c.160G>A	c.(160-162)Gag>Aag	p.E54K	ADNP_ENST00000349014.3_Missense_Mutation_p.E54K|ADNP_ENST00000371602.4_Missense_Mutation_p.E54K|ADNP_ENST00000396032.3_Missense_Mutation_p.E54K	NM_001282531.1|NM_015339.2	NP_001269460.1|NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	54						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						CCTACATCCTCCCATGTAGTG	0.388000													16	132					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209190134	209190134	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:209190134C>T	ENST00000264380.4	+	20	2757	c.2599C>T	c.(2599-2601)Caa>Taa	p.Q867*		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	867					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						TTATCATTCTCAACTAGAAAT	0.433000													7	67					0	0	1	0	0
MRPS31	10240	broad.mit.edu	37	13	41345190	41345190	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:41345190G>A	ENST00000323563.6	-	1	119	c.83C>T	c.(82-84)gCg>gTg	p.A28V		NM_005830.3	NP_005821.2	Q92665	RT31_HUMAN	mitochondrial ribosomal protein S31	28						mitochondrion|ribosome	protein domain specific binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	13		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.52e-08)|Epithelial(112;7.63e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000192)|GBM - Glioblastoma multiforme(144;0.00233)|BRCA - Breast invasive adenocarcinoma(63;0.0706)		AATCGCAGCCGCTGATGTCTC	0.602000													10	35					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55697850	55697850	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:55697850G>C	ENST00000376350.3	-	15	2647	c.2625C>G	c.(2623-2625)atC>atG	p.I875M	PTPRH_ENST00000263434.5_Missense_Mutation_p.I697M	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	875	Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		AGCTGGCATTGATGTAGTCAG	0.582000													3	76					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68748144	68748144	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:68748144C>T	ENST00000309106.3	-	1	311	c.312G>A	c.(310-312)ctG>ctA	p.L104L		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	104						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CAAAGTACATCAGTCTCTTCA	0.577000													9	33					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13766218	13766218	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:13766218A>T	ENST00000265104.4	-	59	10072	c.9968T>A	c.(9967-9969)aTg>aAg	p.M3323K	DNAH5_ENST00000504001.3_Intron	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3323	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TACGCAATCCATGATCCGCAT	0.527000									Kartagener syndrome				11	102					0	0	1	0	0
GFPT1	2673	broad.mit.edu	37	2	69573055	69573055	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:69573055G>A	ENST00000357308.4	-	12	1264	c.1086C>T	c.(1084-1086)gtC>gtT	p.V362V	GFPT1_ENST00000361060.5_Silent_p.V344V	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	362					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						CATCAAAGTTGACTCTTCCTC	0.358000													18	78					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204412719	204412719	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:204412719C>T	ENST00000367187.3	-	20	3430	c.2874G>A	c.(2872-2874)ctG>ctA	p.L958L	PIK3C2B_ENST00000424712.2_Silent_p.L930L	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	958					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GGCCGTCCTTCAGTAACCTGC	0.572000													9	119					0	0	1	0	0
SRRT	51593	broad.mit.edu	37	7	100473261	100473261	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:100473261G>A	ENST00000388793.4	+	2	270	c.50G>A	c.(49-51)aGa>aAa	p.R17K	SRRT_ENST00000432932.1_Missense_Mutation_p.R17K|SRRT_ENST00000347433.4_Missense_Mutation_p.R17K|SRRT_ENST00000457580.2_Missense_Mutation_p.R17K	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	17	Arg-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						GACAAGTTCAGAAGAGAGCGC	0.587000													8	34					0	0	1	0	0
ENPP5	59084	broad.mit.edu	37	6	46135200	46135200	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:46135200G>A	ENST00000371383.2	-	3	1060	c.800C>T	c.(799-801)tCt>tTt	p.S267F	ENPP5_ENST00000492313.1_5'UTR|ENPP5_ENST00000230565.3_Missense_Mutation_p.S267F			Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	267						extracellular region|integral to membrane	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	12						TGCTACTGGAGATTGATCAAT	0.443000													12	64					0	0	1	0	0
LMBR1L	55716	broad.mit.edu	37	12	49491764	49491764	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:49491764G>A	ENST00000267102.8	-	16	1707	c.1365C>T	c.(1363-1365)ttC>ttT	p.F455F	LMBR1L_ENST00000395141.4_Silent_p.F450F|LMBR1L_ENST00000547382.1_Silent_p.F435F	NM_018113.2	NP_060583.2	Q6UX01	LMBRL_HUMAN	limb development membrane protein 1-like	455					endocytosis	integral to membrane|plasma membrane	receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CAGCTGCAGTGAAGGTCTTCA	0.552000											OREG0021783	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	105					0	0	1	0	0
PAF1	54623	broad.mit.edu	37	19	39876663	39876663	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:39876663C>T	ENST00000221265.3	-	14	1894	c.1564G>A	c.(1564-1566)Gat>Aat	p.D522N	PAF1_ENST00000595564.1_Silent_p.L450L|PAF1_ENST00000221266.7_Silent_p.L427L	NM_019088.3	NP_061961.2	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	522					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding	p.D522N(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|urinary_tract(2)	17	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TCACTGGAATCAGAAGCTGCA	0.592000													8	43					0	0	1	0	0
MTMR6	9107	broad.mit.edu	37	13	25828053	25828053	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:25828053G>A	ENST00000381801.5	-	11	1956	c.1195C>T	c.(1195-1197)Cag>Tag	p.Q399*	MTMR6_ENST00000540661.1_Nonsense_Mutation_p.Q399*	NM_004685.3	NP_004676.3	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	399	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(5)|stomach(3)	36		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		TCCAAGAACTGAGTAAACACT	0.423000													4	51					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10746998	10746998	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:10746998G>A	ENST00000586078.1	+	15	1342		c.e15-1		SLC44A2_ENST00000335757.5_Splice_Site|SLC44A2_ENST00000407327.4_Splice_Site	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2						positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	CTCTCCCACAGACCTTCCCCT	0.617000													4	58					0	0	1	0	0
HS2ST1	9653	broad.mit.edu	37	1	87380809	87380809	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:87380809G>A	ENST00000370550.5	+	1	453	c.90G>A	c.(88-90)caG>caA	p.Q30Q	HS2ST1_ENST00000370551.4_Silent_p.Q30Q	NM_012262.3	NP_036394.1	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1	30						Golgi membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)	9		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		TGGAAAACCAGATCCAGAAAC	0.632000													15	61					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32639854	32639854	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:32639854G>A	ENST00000421745.2	+	10	1629	c.1495G>A	c.(1495-1497)Gaa>Aaa	p.E499K		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	499					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					ATCACAGAAGGAAGCCATGGA	0.358000													3	21					0	0	1	0	0
IGSF9	57549	broad.mit.edu	37	1	159907540	159907540	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:159907540G>A	ENST00000368094.1	-	4	533	c.336C>T	c.(334-336)ttC>ttT	p.F112F	IGSF9_ENST00000361509.3_Silent_p.F112F	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	112	Ig-like 1.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GCTGGTCCAGGAAGAACACGC	0.607000													6	49					0	0	1	0	0
ZNF256	10172	broad.mit.edu	37	19	58453797	58453797	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:58453797A>C	ENST00000282308.3	-	3	575	c.379T>G	c.(379-381)Tta>Gta	p.L127V	ZNF256_ENST00000598928.1_3'UTR	NM_005773.2	NP_005764.2	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	127					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		GTAAATTGTAATTGTTTCCTA	0.458000													18	102					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24990987	24990987	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:24990987G>A	ENST00000405141.1	+	24	4906	c.4195G>A	c.(4195-4197)Gac>Aac	p.D1399N	NCOA1_ENST00000538539.1_Missense_Mutation_p.D1399N|NCOA1_ENST00000406961.1_Intron|NCOA1_ENST00000288599.5_Missense_Mutation_p.D1399N|NCOA1_ENST00000407230.1_Missense_Mutation_p.D1248N|NCOA1_ENST00000348332.3_Intron|NCOA1_ENST00000395856.3_Intron			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	0									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGACTACAGACTAGAGGAA	0.433000			T	PAX3	alveolar rhadomyosarcoma								20	119					0	0	1	0	0
TBCEL	219899	broad.mit.edu	37	11	120957741	120957741	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:120957741G>C	ENST00000422003.2	+	8	1399	c.1211G>C	c.(1210-1212)cGg>cCg	p.R404P	TBCEL_ENST00000529397.1_Missense_Mutation_p.R404P	NM_152715.3	NP_689928.3	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	404	Ubiquitin-like.					cytoplasm|cytoskeleton			TECTA/TBCEL(2)	endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		TACAGCTCTCGGGCATTGCAT	0.403000													3	43					0	0	1	0	0
MCM9	254394	broad.mit.edu	37	6	119252744	119252744	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:119252744C>T	ENST00000316316.6	-	2	431	c.145G>A	c.(145-147)Gag>Aag	p.E49K	MCM9_ENST00000316068.3_Missense_Mutation_p.E49K	NM_017696.2	NP_060166.2	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	49					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		ATGTTGGTCTCAAACAGAGTC	0.398000													13	80					0	0	1	0	0
DTX4	23220	broad.mit.edu	37	11	58972306	58972306	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:58972306A>G	ENST00000227451.3	+	9	1888	c.1784A>G	c.(1783-1785)aAt>aGt	p.N595S	DTX4_ENST00000532982.1_Missense_Mutation_p.N489S	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	595					Notch signaling pathway	cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				CCAGATGCCAATTACCTGGAT	0.552000													3	12					0	0	1	0	0
CYR61	3491	broad.mit.edu	37	1	86048266	86048266	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:86048266G>A	ENST00000451137.2	+	4	1026	c.802G>A	c.(802-804)Gag>Aag	p.E268K		NM_001554.4	NP_001545.2	O00622	CYR61_HUMAN	cysteine-rich, angiogenic inducer, 61	268	TSP type-1.				cell proliferation|chemotaxis|positive regulation of BMP signaling pathway|positive regulation of cell migration|positive regulation of osteoblast differentiation|positive regulation of osteoblast proliferation|positive regulation of protein kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell growth|regulation of ERK1 and ERK2 cascade|wound healing, spreading of cells	extracellular region	heparin binding|insulin-like growth factor binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|prostate(1)	5				all cancers(265;0.0216)|Epithelial(280;0.0441)		CCGGATTTGTGAGGTGCGGCC	0.532000											OREG0013583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	50					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100417209	100417209	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:100417209C>T	ENST00000358173.3	-	6	1735	c.1267G>A	c.(1267-1269)Gag>Aag	p.E423K	EPHB4_ENST00000360620.3_Missense_Mutation_p.E423K|EPHB4_ENST00000477446.1_5'UTR	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	423	Fibronectin type-III 1.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					TTGACAGGCTCAAATGGGACG	0.607000													6	51					0	0	1	0	0
DDB1	1642	broad.mit.edu	37	11	61076542	61076542	+	Silent	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:61076542T>C	ENST00000301764.7	-	21	2971	c.2574A>G	c.(2572-2574)ctA>ctG	p.L858L	DDB1_ENST00000450997.2_Silent_p.L169L	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	858	Interaction with CDT1 and CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						CCACAGTCTGTAGTTTTCCTG	0.473000								Nucleotide excision repair (NER)					6	81					0	0	1	0	0
GRIP1	23426	broad.mit.edu	37	12	66839203	66839203	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:66839203G>A	ENST00000359742.4	-	12	1680	c.1440C>T	c.(1438-1440)gtC>gtT	p.V480V	GRIP1_ENST00000286445.7_Silent_p.V480V|GRIP1_ENST00000398016.3_Silent_p.V428V			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	480	PDZ 4.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CAAATCCTGTGACAGGATCTG	0.512000													8	60					0	0	1	0	0
LEO1	123169	broad.mit.edu	37	15	52252196	52252196	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:52252196G>A	ENST00000299601.5	-	5	1120	c.1060C>T	c.(1060-1062)Cct>Tct	p.P354S	LEO1_ENST00000315141.5_Missense_Mutation_p.P354S	NM_138792.2	NP_620147.1	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	354					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|skin(1)	14				all cancers(107;0.00264)		CTGGTCTCAGGAATTGGCTCC	0.413000													8	79					0	0	1	0	0
ACLY	47	broad.mit.edu	37	17	40040509	40040509	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:40040509G>A	ENST00000352035.2	-	19	2221	c.2091C>T	c.(2089-2091)ttC>ttT	p.F697F	ACLY_ENST00000537919.1_Silent_p.F426F|ACLY_ENST00000393896.2_Silent_p.F687F|ACLY_ENST00000590151.1_Silent_p.F697F|ACLY_ENST00000353196.1_Silent_p.F687F	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase	697					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				CATGATCCATGAATGTGGAGC	0.438000													12	61					0	0	1	0	0
MYLK4	340156	broad.mit.edu	37	6	2679554	2679554	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:2679554G>A	ENST00000274643.7	-	9	1189	c.847C>T	c.(847-849)Ccc>Tcc	p.P283S	MYLK4_ENST00000268446.5_Missense_Mutation_p.P283S	NM_001012418.3	NP_001012418.2	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	283	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				ATGTCAGTGGGAAATGAAACA	0.453000													8	121					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52797586	52797586	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:52797586G>A	ENST00000257974.2	-	2	596	c.519C>T	c.(517-519)atC>atT	p.I173I		NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	173	Coil 1B.|Rod.					keratin filament	protein binding|structural constituent of epidermis			endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		GAAGGGCGCTGATATAGCCCT	0.592000													13	59					0	0	1	0	0
DLD	1738	broad.mit.edu	37	7	107557339	107557339	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:107557339G>C	ENST00000205402.5	+	10	1257	c.976G>C	c.(976-978)Gag>Cag	p.E326Q	DLD_ENST00000537148.1_Missense_Mutation_p.E227Q|DLD_ENST00000440410.1_Missense_Mutation_p.E303Q|DLD_ENST00000437604.2_Missense_Mutation_p.E278Q	NM_000108.3	NP_000099.2	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase	326					branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(10)|prostate(1)	20					NADH(DB00157)	GGGACTAGAAGAGCTGGGAAT	0.393000													8	72					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126882832	126882832	+	Nonsense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:126882832T>A	ENST00000339582.2	-	2	1235	c.427A>T	c.(427-429)Aag>Tag	p.K143*	GRM8_ENST00000405249.1_Nonsense_Mutation_p.K143*|GRM8_ENST00000444921.2_Nonsense_Mutation_p.K143*|GRM8_ENST00000358373.3_Nonsense_Mutation_p.K143*			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	143					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TTGTCGGGCTTGGTGAAAATG	0.448000										HNSCC(24;0.065)			12	55					0	0	1	0	0
OR51F2	119694	broad.mit.edu	37	11	4842691	4842691	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:4842691T>G	ENST00000322110.5	+	1	141	c.76T>G	c.(76-78)Ttc>Gtc	p.F26V	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004753.1	NP_001004753.1	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F, member 2	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCTCTGATCTTCCTCCTGAT	0.443000													14	127					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67314370	67314370	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:67314370G>A	ENST00000360461.5	+	1	2958	c.423G>A	c.(421-423)ttG>ttA	p.L141L	PLEKHG4_ENST00000379344.3_Silent_p.L141L|PLEKHG4_ENST00000450733.1_Intron|PLEKHG4_ENST00000427155.2_Silent_p.L141L	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	141					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		CATCTGGCTTGAGCCCTGGGG	0.602000													11	69					0	0	1	0	0
STAT6	6778	broad.mit.edu	37	12	57493798	57493798	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:57493798G>A	ENST00000300134.3	-	14	1913	c.1588C>T	c.(1588-1590)Cgg>Tgg	p.R530W	STAT6_ENST00000556155.1_Missense_Mutation_p.R530W|STAT6_ENST00000543873.2_Missense_Mutation_p.R530W|STAT6_ENST00000454075.3_Missense_Mutation_p.R530W|STAT6_ENST00000537215.2_Missense_Mutation_p.R420W|STAT6_ENST00000538913.2_Missense_Mutation_p.R420W	NM_001178078.1|NM_003153.4	NP_001171549.1|NP_003144.3	P42226	STAT6_HUMAN	signal transducer and activator of transcription 6, interleukin-4 induced	530	SH2.				regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	28						CAGTAGCTCCGGAGACAGCGT	0.597000													4	16					0	0	1	0	0
TRIM50	135892	broad.mit.edu	37	7	72738485	72738485	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:72738485C>G	ENST00000333149.2	-	2	501	c.301G>C	c.(301-303)Gag>Cag	p.E101Q	TRIM50_ENST00000493498.1_5'UTR|TRIM50_ENST00000453152.1_Missense_Mutation_p.E101Q	NM_178125.2	NP_835226.2	Q86XT4	TRI50_HUMAN	tripartite motif containing 50	101						cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)	20						TGGTCCTTCTCGCAGAAAAGG	0.657000											OREG0018105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	99					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86044083	86044083	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:86044083G>A	ENST00000414626.2	+	11	2684	c.1795G>A	c.(1795-1797)Gag>Aag	p.E599K	LRRCC1_ENST00000360375.3_Missense_Mutation_p.E619K			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	619					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						GAAAAAGCATGAGCAAATGAT	0.368000													10	32					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20819711	20819711	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:20819711G>A	ENST00000328879.4	-	4	702	c.546C>T	c.(544-546)ttC>ttT	p.F182F	KLHL22_ENST00000440659.2_Silent_p.F39F	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	182					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CAGTCCGAGAGAAGGCCACAA	0.532000													11	145					0	0	1	0	0
COLEC12	81035	broad.mit.edu	37	18	346398	346398	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:346398C>G	ENST00000400256.3	-	5	1431	c.1224G>C	c.(1222-1224)tcG>tcC	p.S408S		NM_130386.2	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	408					carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity	p.S408S(1)		cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				TGTCTAACCTCGACCTCATCA	0.408000													12	88					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102502930	102502930	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:102502930G>A	ENST00000360184.4	+	57	11023	c.10859G>A	c.(10858-10860)aGa>aAa	p.R3620K	DYNC1H1_ENST00000556791.1_3'UTR|RP11-1017G21.4_ENST00000557551.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3620	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						GACGCCTTCAGAAAGAACTTA	0.468000													15	78					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123928423	123928423	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:123928423G>A	ENST00000373855.1	+	36	5880	c.5620G>A	c.(5620-5622)Gct>Act	p.A1874T	CNTRL_ENST00000238341.5_Missense_Mutation_p.A1874T|CNTRL_ENST00000373850.1_Missense_Mutation_p.A1322T|CNTRL_ENST00000373845.2_3'UTR			Q7Z7A1	CNTRL_HUMAN	centriolin	1874					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GGAGGAACTAGCTAATGTCCA	0.343000													7	29					0	0	1	0	0
SLMAP	7871	broad.mit.edu	37	3	57893610	57893610	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:57893610G>C	ENST00000295951.3	+	16	2616		c.e16-1		SLMAP_ENST00000494088.1_Intron|SLMAP_ENST00000442599.2_Intron|SLMAP_ENST00000295952.3_Splice_Site|SLMAP_ENST00000495364.1_Splice_Site|SLMAP_ENST00000428312.1_Splice_Site|SLMAP_ENST00000449503.2_Splice_Site|SLMAP_ENST00000472546.1_Intron|SLMAP_ENST00000416870.1_Intron			Q14BN4	SLMAP_HUMAN	sarcolemma associated protein						muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(2)	18				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		GTTTTTGTCAGATGACTTGCA	0.368000													14	37					0	0	1	0	0
DDHD2	23259	broad.mit.edu	37	8	38109768	38109768	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:38109768T>G	ENST00000397166.2	+	13	2105	c.1580T>G	c.(1579-1581)tTt>tGt	p.F527C	DDHD2_ENST00000517385.1_Missense_Mutation_p.F146C|DDHD2_ENST00000529845.1_5'UTR|DDHD2_ENST00000520272.2_Missense_Mutation_p.F527C	NM_015214.2	NP_056029.2	O94830	DDHD2_HUMAN	DDHD domain containing 2	527	DDHD.				lipid catabolic process	centrosome	hydrolase activity|metal ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)|urinary_tract(2)	28	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			AACTACAGATTTCCAACGTGC	0.378000													26	129					0	0	1	0	0
TCTN2	79867	broad.mit.edu	37	12	124163768	124163768	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:124163768C>G	ENST00000303372.5	+	5	624	c.496C>G	c.(496-498)Cag>Gag	p.Q166E	TCTN2_ENST00000426174.2_Missense_Mutation_p.Q165E	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	166					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		CCAGGTGTATCAGCCCCTTGG	0.433000													8	106					0	0	1	0	0
GDAP1	54332	broad.mit.edu	37	8	75272543	75272543	+	Missense_Mutation	SNP	G	G	A	rs104894076		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:75272543G>A	ENST00000220822.7	+	3	562	c.482G>A	c.(481-483)cGt>cAt	p.R161H	GDAP1_ENST00000521096.1_3'UTR|GDAP1_ENST00000434412.2_Missense_Mutation_p.R93H	NM_001040875.2|NM_018972.2	NP_001035808.1|NP_061845.2	Q8TB36	GDAP1_HUMAN	ganglioside induced differentiation associated protein 1	161	GST C-terminal.		R -> H (in CMT4A).			cytoplasm				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	Breast(64;0.00769)	Myeloproliferative disorder(644;0.0122)	BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.104)|all cancers(69;0.234)			ACAAGGATTCGTAGTATGTAA	0.403000													13	120					0	0	1	0	0
DPEP3	64180	broad.mit.edu	37	16	68012512	68012512	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:68012512G>A	ENST00000268793.4	-	3	880	c.507C>T	c.(505-507)gtC>gtT	p.V169V	DPEP3_ENST00000574342.1_5'UTR	NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3	144					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		ACTGGCATGAGACGGAGGCTG	0.607000													8	107					0	0	1	0	0
RMND5A	64795	broad.mit.edu	37	2	86992262	86992262	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:86992262G>A	ENST00000283632.4	+	5	1129	c.634G>A	c.(634-636)Gag>Aag	p.E212K		NM_022780.3	NP_073617.1	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	212										kidney(1)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	17						AAATCAGCGAGAGGCATTACA	0.368000													24	82					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82586125	82586125	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:82586125G>A	ENST00000333891.9	-	5	4481	c.4144C>T	c.(4144-4146)Cca>Tca	p.P1382S	PCLO_ENST00000423517.2_Missense_Mutation_p.P1382S	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCATCAGTTGGAATAAGACTT	0.443000													3	31					0	0	1	0	0
CDK11A	728642	broad.mit.edu	37	1	1635007	1635007	+	Silent	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:1635007G>C	ENST00000356200.3	-	17	2100	c.1866C>G	c.(1864-1866)gtC>gtG	p.V622V	CDK11A_ENST00000378633.1_Silent_p.V659V|CDK11A_ENST00000378638.2_Silent_p.V622V|RP1-283E3.8_ENST00000598846.1_RNA|CDK11A_ENST00000357760.2_Silent_p.V655V|CDK11A_ENST00000358779.5_Silent_p.V646V|CDK11A_ENST00000404249.3_Silent_p.V656V					cyclin-dependent kinase 11A											central_nervous_system(1)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(4)|stomach(1)|urinary_tract(1)	18						TCATCTTTTTGACTACTGGGA	0.577000													6	14					0	0	1	0	0
TMCO2	127391	broad.mit.edu	37	1	40717246	40717246	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:40717246G>C	ENST00000372766.3	+	2	622	c.529G>C	c.(529-531)Ggg>Cgg	p.G177R	TMCO2_ENST00000468258.1_3'UTR	NM_001008740.3	NP_001008740.1	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	177						integral to membrane		p.G177R(1)		kidney(1)|large_intestine(3)|lung(1)|ovary(1)	6	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			GTCCACATCAGGGTTTACTTC	0.478000													4	95					0	0	1	0	0
DFNB31	25861	broad.mit.edu	37	9	117186750	117186750	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:117186750T>A	ENST00000362057.3	-	6	1448	c.1280A>T	c.(1279-1281)gAg>gTg	p.E427V	DFNB31_ENST00000374059.3_Missense_Mutation_p.E76V|DFNB31_ENST00000265134.6_Missense_Mutation_p.E44V	NM_001173425.1|NM_015404.3	NP_001166896.1|NP_056219	Q9P202	WHRN_HUMAN	deafness, autosomal recessive 31	427					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|ovary(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AGCCTGCTCCTCCAGCAGCAC	0.617000													8	16					0	0	1	0	0
PIM2	11040	broad.mit.edu	37	X	48775887	48775887	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:48775887G>A	ENST00000376509.4	-	2	286	c.97C>T	c.(97-99)Cga>Tga	p.R33*		NM_006875.3	NP_006866.2	Q9P1W9	PIM2_HUMAN	pim-2 oncogene	33	Protein kinase.				anti-apoptosis|cell proliferation|male meiosis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|response to virus		ATP binding|protein serine/threonine kinase activity			lung(3)|stomach(1)	4						GGGCCGAGTCGATACTCGGCC	0.662000													8	15					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55142253	55142253	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:55142253C>T	ENST00000370862.3	+	5	1174	c.838C>T	c.(838-840)Cag>Tag	p.Q280*		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	280					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AGGGCCAGGACAGCCAACGAA	0.517000													8	31					0	0	1	0	0
SKI	6497	broad.mit.edu	37	1	2160480	2160480	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:2160480T>A	ENST00000378536.4	+	1	347	c.275T>A	c.(274-276)aTg>aAg	p.M92K		NM_003036.3	NP_003027.1	P12755	SKI_HUMAN	v-ski avian sarcoma viral oncogene homolog	92					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|kidney(2)|lung(5)|prostate(1)|stomach(1)	10	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		CCCTTCTTCATGCCGTCCGAC	0.741000													5	16					0	0	1	0	0
SLC4A1	6521	broad.mit.edu	37	17	42336598	42336598	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:42336598C>T	ENST00000262418.6	-	9	964	c.809G>A	c.(808-810)gGa>gAa	p.G270E	AC003043.1_ENST00000597382.1_Intron	NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	270					bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		GGCCTCAGGTCCCAGCAACAC	0.662000													11	60					0	0	1	0	0
AHSP	51327	broad.mit.edu	37	16	31539925	31539925	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:31539925G>A	ENST00000302312.4	+	3	325	c.222G>A	c.(220-222)ctG>ctA	p.L74L	AHSP_ENST00000569954.1_3'UTR	NM_016633.2	NP_057717.1	Q9NZD4	AHSP_HUMAN	alpha hemoglobin stabilizing protein	74					hemoglobin metabolic process|hemopoiesis|protein folding|protein stabilization	hemoglobin complex	hemoglobin binding|unfolded protein binding			lung(2)	2						GGCAAGAGCTGAACACTCTGG	0.577000													8	30					0	0	1	0	0
SASH1	23328	broad.mit.edu	37	6	148795302	148795302	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:148795302C>G	ENST00000367467.3	+	7	1046	c.571C>G	c.(571-573)Cag>Gag	p.Q191E		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	191							protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GGAGCGGATTCAGCTAATGAT	0.418000													7	14					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103284977	103284977	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:103284977G>A	ENST00000520539.1	-	48	7359	c.6753C>T	c.(6751-6753)ctC>ctT	p.L2251L	UBR5_ENST00000518205.1_5'UTR|UBR5_ENST00000521922.1_Silent_p.L2245L|UBR5_ENST00000220959.4_Silent_p.L2251L	NM_001282873.1|NM_015902.5	NP_001269802.1|NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	2251					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TCTGCTGAATGAGAAGATCTC	0.373000													79	61					0	0	1	0	0
ZC3H6	376940	broad.mit.edu	37	2	113089382	113089382	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:113089382C>T	ENST00000409871.1	+	12	3288	c.2887C>T	c.(2887-2889)Cct>Tct	p.P963S	ZC3H6_ENST00000343936.4_Missense_Mutation_p.P963S	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	963							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						ATTAGGAGATCCTAGACTACA	0.418000													13	46					0	0	1	0	0
CENPH	64946	broad.mit.edu	37	5	68504103	68504103	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:68504103G>A	ENST00000283006.2	+	8	655	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	CENPH_ENST00000515001.1_Missense_Mutation_p.E171K	NM_022909.3	NP_075060.1	Q9H3R5	CENPH_HUMAN	centromere protein H	190					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|kinetochore organization|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	kinetochore binding|protein binding			kidney(15)|large_intestine(2)|lung(3)	20		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.41e-56)|Epithelial(20;1.29e-52)|all cancers(19;3.15e-48)|Lung(70;0.0178)		GGACAGTATGGAAAACTCAGA	0.299000													15	51					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83848844	83848844	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:83848844C>T	ENST00000349129.2	+	21	5343	c.5083C>T	c.(5083-5085)Cag>Tag	p.Q1695*	DOPEY1_ENST00000484282.1_3'UTR|DOPEY1_ENST00000369739.3_Nonsense_Mutation_p.Q1686*|DOPEY1_ENST00000237163.5_Nonsense_Mutation_p.Q1676*	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	1695					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TAATCTAATTCAGCAGTACAA	0.348000													14	44					0	0	1	0	0
TMEM79	84283	broad.mit.edu	37	1	156255160	156255160	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:156255160G>A	ENST00000405535.2	+	2	314	c.143G>A	c.(142-144)aGa>aAa	p.R48K	TMEM79_ENST00000295694.5_Missense_Mutation_p.R48K|TMEM79_ENST00000357501.2_Intron|TMEM79_ENST00000495881.1_3'UTR	NM_032323.2	NP_115699.1	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	48						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|urinary_tract(1)	21	Hepatocellular(266;0.158)					GAGTCCCTCAGAGTGGGGTCT	0.627000													6	46					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57577255	57577255	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:57577255C>T	ENST00000243077.3	+	35	6222	c.5756C>T	c.(5755-5757)tCc>tTc	p.S1919F		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1919					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GTCCCAGTGTCCGGGACCTCG	0.587000											OREG0021938	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	36					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47384560	47384560	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:47384560G>A	ENST00000398879.1	-	19	2894	c.2528C>T	c.(2527-2529)tCa>tTa	p.S843L	TNS3_ENST00000311160.9_Missense_Mutation_p.S843L|TNS3_ENST00000355730.3_Missense_Mutation_p.S603L			Q68CZ2	TENS3_HUMAN	tensin 3	843						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						TGCTGGAGTTGAACACATGGA	0.493000													17	45					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7918289	7918289	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:7918289G>A	ENST00000254854.4	+	14	2839	c.2689G>A	c.(2689-2691)Gag>Aag	p.E897K		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	897	Guanylate cyclase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				TGCCATGAGTGAGCCCATTGA	0.517000													5	49					0	0	1	0	0
RFC5	5985	broad.mit.edu	37	12	118467591	118467591	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:118467591C>T	ENST00000392542.2	+	11	1357	c.824C>T	c.(823-825)tCa>tTa	p.S275L	RFC5_ENST00000454402.2_Missense_Mutation_p.S296L|RFC5_ENST00000229043.3_Missense_Mutation_p.S211L|RFC5_ENST00000543153.1_3'UTR	NM_181578.3	NP_853556.2	P40937	RFC5_HUMAN	replication factor C (activator 1) 5, 36.5kDa	296					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTTCCATCTTCAGTTCGAATA	0.363000													20	132					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34826202	34826202	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:34826202C>A	ENST00000192788.5	+	14	2240	c.2069C>A	c.(2068-2070)tCc>tAc	p.S690Y	UHRF1BP1_ENST00000452449.2_Missense_Mutation_p.S690Y	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	690										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						CCTAAGGCTTCCTGGGATCTC	0.502000													19	77					8.34094e-07	8.5959e-07	1	1	0
SYNE2	23224	broad.mit.edu	37	14	64497937	64497937	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:64497937C>T	ENST00000358025.3	+	45	7313	c.7083C>T	c.(7081-7083)ctC>ctT	p.L2361L	SYNE2_ENST00000344113.4_Silent_p.L2361L|SYNE2_ENST00000554584.1_Silent_p.L2361L|SYNE2_ENST00000357395.3_5'UTR	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2361					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ACAGCATTCTCAAATCAAAAC	0.408000													14	61					0	0	1	0	0
RNF19A	25897	broad.mit.edu	37	8	101271122	101271122	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:101271122G>C	ENST00000519449.1	-	11	2495	c.2179C>G	c.(2179-2181)Cat>Gat	p.H727D	RNF19A_ENST00000341084.2_Missense_Mutation_p.H727D	NM_001280539.1|NM_015435.3	NP_001267468.1|NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	727	Interaction with CASR.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding	p.H727N(1)		breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			TCAGAAAAATGACTAGAGTGA	0.408000											OREG0018897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	112	128					0	0	1	0	0
WDR88	126248	broad.mit.edu	37	19	33666477	33666477	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:33666477G>A	ENST00000355868.3	+	11	1494	c.1418G>A	c.(1417-1419)tGa>tAa	p.*473*	WDR88_ENST00000361680.2_3'UTR	NM_173479.3	NP_775750.3	Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	0										breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					AAGGATGACTGACAGCCACAG	0.572000													9	55					0	0	1	0	0
LGALS1	3956	broad.mit.edu	37	22	38073013	38073013	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:38073013G>A	ENST00000215909.5	+	2	125	c.30G>A	c.(28-30)ctG>ctA	p.L10L	LGALS1_ENST00000489315.1_3'UTR	NM_002305.3	NP_002296.1	P09382	LEG1_HUMAN	lectin, galactoside-binding, soluble, 1	10	Galectin.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of apoptosis	cytoplasm|extracellular space|proteinaceous extracellular matrix	galactoside binding|signal transducer activity			endometrium(1)|large_intestine(1)|lung(1)	3	Melanoma(58;0.0574)					CCAGCAACCTGAATCTCAAAC	0.652000													6	30					0	0	1	0	0
KRT33B	3884	broad.mit.edu	37	17	39521224	39521224	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:39521224C>T	ENST00000251646.3	-	6	953	c.904G>A	c.(904-906)Gag>Aag	p.E302K		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	302	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				GCCTCGCTCTCTGTCAGCGTG	0.577000													12	44					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186158848	186158848	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:186158848G>C	ENST00000271588.4	+	107	16975	c.16746G>C	c.(16744-16746)ttG>ttC	p.L5582F	HMCN1_ENST00000367492.2_Missense_Mutation_p.L5465F	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	5582					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CTTTTGCCTTGAGGGATGAAA	0.493000													32	43					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158912102	158912102	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:158912102C>T	ENST00000368140.1	+	5	1160	c.915C>T	c.(913-915)atC>atT	p.I305I	PYHIN1_ENST00000392252.3_Silent_p.I296I|PYHIN1_ENST00000485134.1_3'UTR|PYHIN1_ENST00000392254.2_Silent_p.I305I|PYHIN1_ENST00000368138.3_Silent_p.I296I	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	305	HIN-200.				cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					AGGACATCATCAGAAGAGCAA	0.368000													32	43					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52883351	52883351	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:52883351G>A	ENST00000343457.3	-	1	435	c.429C>T	c.(427-429)ttC>ttT	p.F143F		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	143						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						ACCTGTTTCTGAAGCTGCTTC	0.438000													39	51					0	0	1	0	0
LZTS2	84445	broad.mit.edu	37	10	102763725	102763725	+	Silent	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:102763725T>A	ENST00000370220.1	+	2	3933	c.870T>A	c.(868-870)gcT>gcA	p.A290A	LZTS2_ENST00000370223.3_Silent_p.A290A			Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	290	Required for centrosomal localization (By similarity).|Ser-rich.				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				breast(1)|large_intestine(6)|lung(7)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		GCCGTGTGGCTGGGGGGCTTT	0.701000													5	31					0	0	1	0	0
CYGB	114757	broad.mit.edu	37	17	74533528	74533528	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:74533528G>A	ENST00000293230.5	-	1	459	c.97C>T	c.(97-99)Cgg>Tgg	p.R33W	PRCD_ENST00000592432.1_Intron|CYGB_ENST00000589145.1_Intron|CYGB_ENST00000589342.1_Missense_Mutation_p.R33W	NM_134268.4	NP_599030.1	Q8WWM9	CYGB_HUMAN	cytoglobin	33	Globin.				response to oxidative stress	cytoplasm	heme binding|oxygen binding|oxygen transporter activity|peroxidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)	7						GCATAGAGCCGGGCCCACATA	0.706000													5	16					0	0	1	0	0
CCNF	899	broad.mit.edu	37	16	2488121	2488121	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:2488121C>G	ENST00000397066.4	+	6	679	c.591C>G	c.(589-591)ttC>ttG	p.F197L		NM_001761.2	NP_001752.2	P41002	CCNF_HUMAN	cyclin F	197					cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(2)|lung(5)|prostate(4)|skin(1)	20		Ovarian(90;0.17)				TGAGTCTGTTCGAGGTGAGTC	0.493000													11	68					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926155	1926155	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:1926155C>T	ENST00000399161.2	-	10	2133	c.1386G>A	c.(1384-1386)atG>atA	p.M462I	MYT1L_ENST00000428368.2_Missense_Mutation_p.M462I	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	462					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CATATGACCTCATATTGTCCC	0.512000													24	89					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167313510	167313510	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:167313510C>A	ENST00000409855.1	-	10	1286	c.1160G>T	c.(1159-1161)aGt>aTt	p.S387I		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	387					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						TAAGAACAAACTTGCCATATA	0.353000													3	12					0.004672	0.00472539	1	1	0
KLRG2	346689	broad.mit.edu	37	7	139164455	139164455	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:139164455G>A	ENST00000340940.4	-	3	992	c.923C>T	c.(922-924)tCt>tTt	p.S308F	KLRG2_ENST00000393039.2_Intron	NM_198508.2	NP_940910.1	A4D1S0	KLRG2_HUMAN	killer cell lectin-like receptor subfamily G, member 2	308	C-type lectin.					integral to membrane	sugar binding			central_nervous_system(1)|large_intestine(2)|lung(3)	6	Melanoma(164;0.233)					CGCTTCTGCAGAGAAGTAGTA	0.617000													3	29					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88329002	88329002	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:88329002C>T	ENST00000325089.6	+	2	1578	c.1359C>T	c.(1357-1359)ttC>ttT	p.F453F	SLITRK5_ENST00000400028.3_Silent_p.F212F	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	453						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ACCGCGCTTTCGGGGATCTCA	0.597000													5	46					0	0	1	0	0
TOM1L2	146691	broad.mit.edu	37	17	17772754	17772754	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:17772754G>A	ENST00000581396.1	-	7	757	c.661C>T	c.(661-663)Cgc>Tgc	p.R221C	TOM1L2_ENST00000379504.3_Missense_Mutation_p.R271C|TOM1L2_ENST00000577517.1_5'UTR|TOM1L2_ENST00000318094.10_Missense_Mutation_p.R226C|TOM1L2_ENST00000535933.1_Missense_Mutation_p.R218C|TOM1L2_ENST00000395739.4_Missense_Mutation_p.R226C|TOM1L2_ENST00000540946.1_Missense_Mutation_p.R173C|TOM1L2_ENST00000542206.1_Missense_Mutation_p.R123C|TOM1L2_ENST00000478943.1_Missense_Mutation_p.R4C	NM_001033551.2	NP_001028723.1	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 (chicken)	271	GAT.				intracellular protein transport	intracellular				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(2)	10	all_neural(463;0.228)					TCCACGATGCGCTGCTGCATG	0.557000													6	33					0	0	1	0	0
A3GALT2	127550	broad.mit.edu	37	1	33772966	33772966	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:33772966C>T	ENST00000442999.3	-	5	423	c.424G>A	c.(424-426)Gag>Aag	p.E142K	RP11-415J8.3_ENST00000588828.1_RNA|A3GALT2_ENST00000330379.5_Missense_Mutation_p.E87K	NM_001080438.1	NP_001073907.1			alpha 1,3-galactosyltransferase 2														Myeloproliferative disorder(586;0.0393)				CCCGGAAGCTCGGTGAACACG	0.701000													7	59					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94732158	94732158	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:94732158T>G	ENST00000304338.3	+	22	2466	c.2312T>G	c.(2311-2313)aTt>aGt	p.I771S		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	771						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TCCAAACTGATTCGAAGCCAG	0.378000													9	106					0	0	1	0	0
SYTL1	84958	broad.mit.edu	37	1	27680316	27680316	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:27680316C>G	ENST00000543823.1	+	14	2124	c.1662C>G	c.(1660-1662)ctC>ctG	p.L554L	SYTL1_ENST00000490170.1_3'UTR|SYTL1_ENST00000318074.5_Silent_p.L542L			Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	554					exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			NS(1)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	12		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TTCTACCCCTCAGAACCAACC	0.597000													12	19					0	0	1	0	0
GBAP1	2630	broad.mit.edu	37	1	155184431	155184431	+	RNA	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:155184431C>T	ENST00000486869.1	-	0	1162					NR_002188.2																						GTTCTTCTGACTGGCAACCAG	0.577000													3	21					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36407633	36407633	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:36407633G>A	ENST00000405275.2	+	11	1089	c.846G>A	c.(844-846)atG>atA	p.M282I	CTNNBL1_ENST00000373473.1_Missense_Mutation_p.M122I|CTNNBL1_ENST00000373469.1_Missense_Mutation_p.M57I|CTNNBL1_ENST00000361383.6_Missense_Mutation_p.M309I|CTNNBL1_ENST00000473857.1_3'UTR	NM_001281495.1	NP_001268424.1	Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	309					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				AGCAGGAGATGATGGAGAATC	0.468000													5	37					0	0	1	0	0
AEBP1	165	broad.mit.edu	37	7	44152334	44152334	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:44152334G>A	ENST00000223357.3	+	18	2700	c.2395G>A	c.(2395-2397)Gag>Aag	p.E799K	AEBP1_ENST00000450684.2_Missense_Mutation_p.E374K	NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	799	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						GGATGAGGACGAGGTCTCCGA	0.672000													3	18					0	0	1	0	0
C3orf38	285237	broad.mit.edu	37	3	88205252	88205252	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:88205252C>T	ENST00000318887.3	+	3	767	c.457C>T	c.(457-459)Ctt>Ttt	p.L153F	C3orf38_ENST00000486971.1_Intron	NM_173824.3	NP_776185.2	Q5JPI3	CC038_HUMAN	chromosome 3 open reading frame 38	153					apoptosis					breast(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	12		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		CTTTGGACTTCTTAATTCTCA	0.378000													20	53					0	0	1	0	0
CAMK2G	818	broad.mit.edu	37	10	75609037	75609037	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:75609037G>A	ENST00000423381.1	-	6	519	c.396C>T	c.(394-396)atC>atT	p.I132I	CAMK2G_ENST00000305762.7_Silent_p.I132I|CAMK2G_ENST00000322680.3_Silent_p.I132I|CAMK2G_ENST00000322635.3_Silent_p.I132I|CAMK2G_ENST00000394762.2_Silent_p.I132I|CAMK2G_ENST00000444854.2_Intron|CAMK2G_ENST00000372765.1_Silent_p.I132I|CAMK2G_ENST00000472912.1_5'UTR|CAMK2G_ENST00000351293.3_Silent_p.I132I	NM_001204492.1	NP_001191421.1	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II gamma	132	Protein kinase.				insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity	p.I132I(2)		kidney(2)|large_intestine(2)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	15	Prostate(51;0.0112)					CCCTGTGGACGATGTCATGCT	0.522000											OREG0020267	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	12					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122418383	122418383	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:122418383C>G	ENST00000474629.2	+	6	1248	c.982C>G	c.(982-984)Ctt>Gtt	p.L328V		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		GTCACTAGATCTTCCCTTATG	0.453000													7	74					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116339702	116339702	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:116339702A>G	ENST00000397752.3	+	2	764	c.564A>G	c.(562-564)gtA>gtG	p.V188V	MET_ENST00000318493.6_Silent_p.V188V|MET_ENST00000436117.2_Silent_p.V188V	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	188	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTTCATCTGTAAAGGACCGGT	0.463000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				10	80					0	0	1	0	0
AFTPH	54812	broad.mit.edu	37	2	64794729	64794729	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:64794729G>A	ENST00000422803.1	+	3	2283	c.1969G>A	c.(1969-1971)Gaa>Aaa	p.E657K	AFTPH_ENST00000238856.4_Missense_Mutation_p.E657K|AFTPH_ENST00000238855.7_Missense_Mutation_p.E657K|AFTPH_ENST00000409933.1_Missense_Mutation_p.E657K|AFTPH_ENST00000409183.1_Missense_Mutation_p.E288K|AFTPH_ENST00000487769.1_Intron			Q6ULP2	AFTIN_HUMAN	aftiphilin	657					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						GCGAATTTTCGAAGCATGTTT	0.378000													10	140					0	0	1	0	0
LOH12CR1	118426	broad.mit.edu	37	12	12588635	12588635	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:12588635C>T	ENST00000314565.4	+	3	607	c.276C>T	c.(274-276)ctC>ctT	p.L92L	LOH12CR1_ENST00000298571.6_Silent_p.L44L|LOH12CR1_ENST00000542728.1_Silent_p.L73L	NM_058169.3	NP_477517.1	Q969J3	L12R1_HUMAN	loss of heterozygosity, 12, chromosomal region 1	92										kidney(1)|large_intestine(1)|lung(1)|ovary(1)	4		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.0205)		TGTTGCAGCTCTGCCTCCGAT	0.463000													8	83					0	0	1	0	0
USP48	84196	broad.mit.edu	37	1	22079540	22079540	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:22079540T>A	ENST00000308271.9	-	4	1133	c.485A>T	c.(484-486)tAc>tTc	p.Y162F	USP48_ENST00000400301.1_Missense_Mutation_p.Y162F|USP48_ENST00000421625.2_Missense_Mutation_p.Y162F|USP48_ENST00000529637.1_Missense_Mutation_p.Y162F	NM_032236.5	NP_115612.4	Q86UV5	UBP48_HUMAN	ubiquitin specific peptidase 48	162					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(14)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		TGGATCAATGTATCGCCTATT	0.363000													11	70					0	0	1	0	0
PDP2	57546	broad.mit.edu	37	16	66918706	66918706	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:66918706G>A	ENST00000311765.2	+	2	853	c.519G>A	c.(517-519)atG>atA	p.M173I	PDP2_ENST00000568720.1_Intron	NM_020786.2	NP_065837.1	Q9P2J9	PDP2_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 2	173					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		TGGAGCACATGGAGGGAGCTA	0.542000													17	34					0	0	1	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213290731	213290731	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:213290731T>A	ENST00000366960.3	+	5	601	c.451T>A	c.(451-453)Ttt>Att	p.F151I	RPS6KC1_ENST00000366959.3_Missense_Mutation_p.F139I|RPS6KC1_ENST00000490299.1_Intron|RPS6KC1_ENST00000543354.1_Intron|RPS6KC1_ENST00000543470.1_5'UTR	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	151					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		CATTGATACCTTTCCTGAGTG	0.343000													9	88					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179597028	179597028	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:179597028C>T	ENST00000589042.1	-	57	16892	c.16668G>A	c.(16666-16668)aaG>aaA	p.K5556K	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.K5239K|TTN_ENST00000342992.6_Silent_p.K4312K|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5239	Ig-like 36.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCTCCCTTCTTTAACAGCT	0.393000													18	110					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10355214	10355214	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:10355214G>A	ENST00000377086.1	+	18	1863	c.1661G>A	c.(1660-1662)gGa>gAa	p.G554E	KIF1B_ENST00000263934.6_Missense_Mutation_p.G508E|KIF1B_ENST00000377083.1_Missense_Mutation_p.G508E|KIF1B_ENST00000377081.1_Missense_Mutation_p.G554E|KIF1B_ENST00000377093.4_Missense_Mutation_p.G508E			O60333	KIF1B_HUMAN	kinesin family member 1B	554					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		ATCAAAGATGGAATTACAAGG	0.353000													9	57					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94129050	94129050	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:94129050G>A	ENST00000369303.4	-	1	194	c.10C>T	c.(10-12)Caa>Taa	p.Q4*	EPHA7_ENST00000369297.1_Nonsense_Mutation_p.Q4*	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	4						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TACCGAGTTTGAAAAACCATG	0.438000													10	25					0	0	1	0	0
ZC3H12A	80149	broad.mit.edu	37	1	37941262	37941262	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:37941262C>T	ENST00000373087.6	+	2	281	c.165C>T	c.(163-165)ttC>ttT	p.F55F		NM_025079.2	NP_079355.2	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	55					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGACTTCTTCCGGAAGCTGG	0.627000													4	39					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24816096	24816096	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:24816096C>T	ENST00000395799.3	+	13	4037	c.3908C>T	c.(3907-3909)tCa>tTa	p.S1303L	TNRC6A_ENST00000315183.7_Intron|CTD-2515A14.1_ENST00000568895.1_RNA	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1303	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		CTTCCCCCTTCAAATAGTGCA	0.448000													13	74					0	0	1	0	0
SLC1A4	6509	broad.mit.edu	37	2	65231130	65231130	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:65231130G>A	ENST00000234256.3	+	3	857	c.614G>A	c.(613-615)gGa>gAa	p.G205E	SLC1A4_ENST00000531327.1_5'UTR|SLC1A4_ENST00000493121.1_3'UTR	NM_003038.4	NP_003029.2	P43007	SATT_HUMAN	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	205					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|urinary_tract(1)	13					L-Alanine(DB00160)	AGCAGCTCTGGAAATGTAACC	0.388000													9	45					0	0	1	0	0
POU3F2	5454	broad.mit.edu	37	6	99283990	99283990	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:99283990C>T	ENST00000328345.5	+	1	1411	c.1241C>T	c.(1240-1242)cCt>cTt	p.P414L		NM_005604.3	NP_005595.2	P20265	PO3F2_HUMAN	POU class 3 homeobox 2	414					positive regulation of cell proliferation		identical protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(5)	10		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0355)		AGGATGACCCCTCCCGGAGGG	0.607000													7	34					0	0	1	0	0
TIPARP	25976	broad.mit.edu	37	3	156395769	156395769	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:156395769G>A	ENST00000461166.1	+	2	871	c.283G>A	c.(283-285)Gaa>Aaa	p.E95K	TIPARP_ENST00000542783.1_Missense_Mutation_p.E95K|TIPARP_ENST00000295924.7_Missense_Mutation_p.E95K|TIPARP_ENST00000486483.1_Missense_Mutation_p.E95K	NM_001184717.1	NP_001171646.1	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	95							NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GAAAGCCATGGAAATCAATTC	0.433000													17	100					0	0	1	0	0
FOXE1	2304	broad.mit.edu	37	9	100616566	100616566	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:100616566G>A	ENST00000375123.3	+	1	1031	c.370G>A	c.(370-372)Ggc>Agc	p.G124S		NM_004473.3	NP_004464.2	O00358	FOXE1_HUMAN	forkhead box E1 (thyroid transcription factor 2)	124					cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(62;0.158)				CCCGGGTAAGGGCAACTACTG	0.642000													8	43					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9512243	9512243	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:9512243C>T	ENST00000402466.1	+	20	3299	c.2531C>T	c.(2530-2532)tCt>tTt	p.S844F	SETD5_ENST00000402198.1_Missense_Mutation_p.S942F|SETD5_ENST00000406341.1_Missense_Mutation_p.S942F|SETD5_ENST00000302463.6_Missense_Mutation_p.S844F|SETD5_ENST00000407969.1_Missense_Mutation_p.S961F			Q9C0A6	SETD5_HUMAN	SET domain containing 5	942										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		TCAGGTCATTCTGACCTGGCT	0.507000													78	107					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169699605	169699605	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:169699605C>T	ENST00000333360.7	-	5	822	c.683G>A	c.(682-684)gGa>gAa	p.G228E	SELE_ENST00000367777.1_Missense_Mutation_p.G228E|SELE_ENST00000367779.4_Missense_Mutation_p.G228E|SELE_ENST00000367776.1_Missense_Mutation_p.G228E|SELE_ENST00000367780.4_Intron|SELE_ENST00000367774.1_Missense_Mutation_p.G228E|SELE_ENST00000367775.1_Intron|SELE_ENST00000367782.4_Missense_Mutation_p.G228E|SELE_ENST00000367781.4_Missense_Mutation_p.G228E|C1orf112_ENST00000498289.1_Intron	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	228	Sushi 1.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					ACTCCATTCTCCAGAGGACAT	0.473000													26	83					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31642624	31642624	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:31642624C>T	ENST00000399332.1	-	6	1382	c.894G>A	c.(892-894)ctG>ctA	p.L298L	HECTD1_ENST00000553700.1_Silent_p.L298L	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	298					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GCTCCGACCTCAGAAGATCCT	0.348000													16	66					0	0	1	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84518094	84518094	+	RNA	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:84518094T>C	ENST00000331369.5	+	0	288																											CACCTGTTCATTGGAGGTGTC	0.507000													29	91					0	0	1	0	0
SERPINE1	5054	broad.mit.edu	37	7	100771815	100771815	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:100771815G>A	ENST00000223095.4	+	2	298	c.141G>A	c.(139-141)gcG>gcA	p.A47A	SERPINE1_ENST00000445463.2_Silent_p.A32A	NM_000602.4	NP_000593.1	P05121	PAI1_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	47					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)	20	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	AGCAGGTGGCGCAGGCCTCCA	0.612000													7	43					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190067825	190067825	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:190067825A>G	ENST00000367462.3	-	8	1855	c.1624T>C	c.(1624-1626)Tac>Cac	p.Y542H	BRINP3_ENST00000534846.1_Missense_Mutation_p.Y440H	NM_199051.1	NP_950252.1			bone morphogenetic protein/retinoic acid inducible neural-specific 3	542																	CTTGACTTGTACTTATTGCTC	0.443000													7	74					0	0	1	0	0
GLIPR1L2	144321	broad.mit.edu	37	12	75816709	75816709	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:75816709G>A	ENST00000550916.1	+	4	657	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K	GLIPR1L2_ENST00000435775.1_Silent_p.*169*|GLIPR1L2_ENST00000378692.3_Missense_Mutation_p.E97K|GLIPR1L2_ENST00000441218.1_Missense_Mutation_p.E139K|GLIPR1L2_ENST00000547164.1_Silent_p.*169*|GLIPR1L2_ENST00000320460.4_Missense_Mutation_p.E204K	NM_001270396.1	NP_001257325.1	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	204						integral to membrane				kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16						AAGACCTTATGAACCAGGAAT	0.303000													39	104					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	61					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152522654	152522654	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:152522654C>A	ENST00000427231.2	-	41	5183	c.4981G>T	c.(4981-4983)Gat>Tat	p.D1661Y	NEB_ENST00000604864.1_Missense_Mutation_p.D1661Y|NEB_ENST00000603639.1_Missense_Mutation_p.D1661Y|NEB_ENST00000409198.1_Missense_Mutation_p.D1661Y|NEB_ENST00000397345.3_Missense_Mutation_p.D1661Y|NEB_ENST00000172853.10_Missense_Mutation_p.D1661Y	NM_001164507.1|NM_001271208.1	NP_001157979|NP_001258137.1	P20929	NEBU_HUMAN	nebulin	1661					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCAAGGCATCGGGCAGGAGA	0.483000													19	82					6.33239e-15	6.64197e-15	1	1	0
ARHGAP32	9743	broad.mit.edu	37	11	128850508	128850508	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:128850508C>T	ENST00000310343.9	-	17	1873	c.1874G>A	c.(1873-1875)gGa>gAa	p.G625E	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.G276E|ARHGAP32_ENST00000524655.1_Missense_Mutation_p.G551E|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.G276E	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	625					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						AGGTCCTTCTCCTACTTCGAT	0.403000													10	71					0	0	1	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917944	48917944	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:48917944G>A	ENST00000311378.4	+	2	1823	c.1295G>A	c.(1294-1296)tGt>tAt	p.C432Y	RP11-506D12.5_ENST00000572491.2_RNA|WFIKKN2_ENST00000426127.1_Missense_Mutation_p.C339Y	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	432	BPTI/Kunitz inhibitor 2.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CGTGAGGCCTGTGAGGAGTCG	0.622000													7	82					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	23689550	23689550	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:23689550G>C	ENST00000546136.1	-	13	1788	c.1786C>G	c.(1786-1788)Caa>Gaa	p.Q596E	SOX5_ENST00000545921.1_Missense_Mutation_p.Q599E|SOX5_ENST00000537393.1_Missense_Mutation_p.Q574E|SOX5_ENST00000309359.1_Missense_Mutation_p.Q596E|SOX5_ENST00000541536.1_Missense_Mutation_p.Q488E|SOX5_ENST00000451604.2_Missense_Mutation_p.Q609E|SOX5_ENST00000381381.2_Missense_Mutation_p.Q488E|SOX5_ENST00000396007.2_Missense_Mutation_p.Q223E			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	609					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						AGACGGGCTTGCTCCTCATAA	0.493000													5	99					0	0	1	0	0
KDM1A	23028	broad.mit.edu	37	1	23376915	23376915	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:23376915C>T	ENST00000400181.4	+	4	717	c.613C>T	c.(613-615)Cat>Tat	p.H205Y	KDM1A_ENST00000356634.3_Missense_Mutation_p.H185Y|KDM1A_ENST00000542151.1_Missense_Mutation_p.H205Y|RP1-184J9.2_ENST00000427154.1_RNA	NM_001009999.2	NP_001009999.1	O60341	KDM1A_HUMAN	lysine (K)-specific demethylase 1A	185	SWIRM.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(2)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						CCGACTTCCTCATGACCGGAT	0.463000													13	61					0	0	1	0	0
GZF1	64412	broad.mit.edu	37	20	23345818	23345818	+	Silent	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:23345818G>T	ENST00000338121.5	+	2	875	c.798G>T	c.(796-798)ccG>ccT	p.P266P	GZF1_ENST00000377051.2_Silent_p.P266P|GZF1_ENST00000544236.1_Intron|GZF1_ENST00000542987.1_Intron			Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	266					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|urinary_tract(2)	24	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					ACCAAAGCCCGGACAGGGTGG	0.547000													14	49					1.49906e-05	1.53705e-05	1	1	0
UBXN11	91544	broad.mit.edu	37	1	26612463	26612463	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:26612463C>T	ENST00000314675.7	-	5	344	c.265G>A	c.(265-267)Gag>Aag	p.E89K	UBXN11_ENST00000357089.4_Missense_Mutation_p.E176K|UBXN11_ENST00000374221.3_Missense_Mutation_p.E209K|UBXN11_ENST00000535108.1_Missense_Mutation_p.E51K|UBXN11_ENST00000436301.2_Missense_Mutation_p.E134K|UBXN11_ENST00000374223.1_5'UTR|UBXN11_ENST00000374222.1_Missense_Mutation_p.E209K|UBXN11_ENST00000374217.2_Missense_Mutation_p.E176K	NM_001077262.1	NP_001070730.1	Q5T124	UBX11_HUMAN	UBX domain protein 11	209						cytoplasm|cytoskeleton				endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(3)	23						ACCACCAGCTCACTAAGATCC	0.627000											OREG0013265	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	22					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3627231	3627231	+	Translation_Start_Site	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:3627231T>C	ENST00000325418.4	+	1	21	c.2T>C	c.(1-3)aTg>aCg	p.M1T	ITGAE_ENST00000263087.4_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	1					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										GTGCCGGCCATGGCGGCTTCG	0.731000													12	27					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39226141	39226141	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:39226141G>A	ENST00000340369.3	-	2	5024	c.4796C>T	c.(4795-4797)tCa>tTa	p.S1599L	XIRP1_ENST00000421646.1_Missense_Mutation_p.S282L|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1599							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CTCCTGGCCTGAGCCACTGGG	0.562000													40	170					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77471194	77471194	+	Silent	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:77471194T>C	ENST00000560626.2	-	4	3550	c.3075A>G	c.(3073-3075)ctA>ctG	p.L1025L	PEAK1_ENST00000312493.4_Silent_p.L1025L|PEAK1_ENST00000558305.1_Silent_p.L1025L			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1025					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.L1025L(2)									CTGAGTCCTGTAGTAATGCAT	0.458000													12	43					0	0	1	0	0
N4BP3	23138	broad.mit.edu	37	5	177546903	177546903	+	Missense_Mutation	SNP	C	C	T	rs141941070		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:177546903C>T	ENST00000274605.5	+	2	678	c.319C>T	c.(319-321)Cgc>Tgc	p.R107C		NM_015111.1	NP_055926.1	O15049	N4BP3_HUMAN	NEDD4 binding protein 3	107						cytoplasmic vesicle membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	9	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAACGGGGTCGCTTTGACAA	0.637000													4	30					0	0	1	0	0
STC1	6781	broad.mit.edu	37	8	23711974	23711974	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:23711974C>T	ENST00000290271.2	-	1	346	c.63G>A	c.(61-63)gcG>gcA	p.A21A		NM_003155.2	NP_003146.1	P52823	STC1_HUMAN	stanniocalcin 1	21					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		CATTCTGCTCCGCCTCATGGG	0.517000													11	90					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95658507	95658507	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:95658507G>A	ENST00000433389.2	+	4	677	c.487G>A	c.(487-489)Gag>Aag	p.E163K	ESRP1_ENST00000358397.5_Missense_Mutation_p.E163K|ESRP1_ENST00000454170.2_Missense_Mutation_p.E163K|ESRP1_ENST00000423620.2_Missense_Mutation_p.E163K	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	163					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						CACAATGACAGAGTGTATCCT	0.328000													15	57					0	0	1	0	0
SLC25A12	8604	broad.mit.edu	37	2	172669970	172669970	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:172669970C>T	ENST00000422440.2	-	11	1087	c.1050G>A	c.(1048-1050)gtG>gtA	p.V350V	SLC25A12_ENST00000392592.4_Silent_p.V243V	NM_003705.4	NP_003696.2	O75746	CMC1_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 12	350					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|upper_aerodigestive_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	TTCGGGTCTTCACCAGATCTA	0.418000													26	157					0	0	1	0	0
TGFBR3	7049	broad.mit.edu	37	1	92174284	92174284	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:92174284C>T	ENST00000212355.4	-	14	2688	c.2223G>A	c.(2221-2223)atG>atA	p.M741I	TGFBR3_ENST00000525962.1_Missense_Mutation_p.M741I|TGFBR3_ENST00000370399.2_Missense_Mutation_p.M740I	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	741					BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TATTCTGCATCATGGCCCAGA	0.537000													6	56					0	0	1	0	0
PSMB10	5699	broad.mit.edu	37	16	67968468	67968468	+	Missense_Mutation	SNP	C	C	G	rs142229777		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:67968468C>G	ENST00000358514.4	-	8	1154	c.817G>C	c.(817-819)Gag>Cag	p.E273Q	CTC-479C5.12_ENST00000573493.1_Intron	NM_002801.3	NP_002792.1	P40306	PSB10_HUMAN	proteasome (prosome, macropain) subunit, beta type, 10	273					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|humoral immune response|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			NS(2)|endometrium(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		TCAGCTTACTCCACCTCCATA	0.522000													61	107					0	0	1	0	0
DLK1	8788	broad.mit.edu	37	14	101201203	101201203	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:101201203C>T	ENST00000341267.4	+	5	1364	c.1122C>T	c.(1120-1122)ttC>ttT	p.F374F	DLK1_ENST00000331224.6_Silent_p.F301F	NM_003836.5	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog (Drosophila)	374					multicellular organismal development	extracellular space|integral to membrane|soluble fraction				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(16)|ovary(2)|prostate(1)|skin(1)	29		Melanoma(154;0.155)				TGACCACCTTCAGCAAGGAGG	0.552000													7	52					0	0	1	0	0
RNF8	9025	broad.mit.edu	37	6	37358522	37358522	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:37358522G>A	ENST00000469731.1	+	7	1315	c.1241G>A	c.(1240-1242)aGa>aAa	p.R414K	RNF8_ENST00000373479.4_Silent_p.K482K			O76064	RNF8_HUMAN	ring finger protein 8, E3 ubiquitin protein ligase	334					cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	13						CCAAAGCAAAGAGATTGTTCT	0.502000													3	51					0	0	1	0	0
SLX4IP	128710	broad.mit.edu	37	20	10579381	10579381	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:10579381C>T	ENST00000334534.5	+	5	477	c.297C>T	c.(295-297)atC>atT	p.I99I		NM_001009608.1	NP_001009608.1			SLX4 interacting protein																		TTCGCTGCATCAGGAGCACAC	0.433000													17	46					0	0	1	0	0
MIB2	142678	broad.mit.edu	37	1	1562790	1562790	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:1562790G>A	ENST00000357210.4	+	12	1879	c.1663G>A	c.(1663-1665)Gag>Aag	p.E555K	MIB2_ENST00000505820.2_Missense_Mutation_p.E612K|MIB2_ENST00000520777.1_Missense_Mutation_p.E608K|MIB2_ENST00000504599.1_Missense_Mutation_p.E511K|MIB2_ENST00000378708.1_Missense_Mutation_p.E461K|MIB2_ENST00000355826.5_Missense_Mutation_p.E598K|MIB2_ENST00000518681.1_Missense_Mutation_p.E547K|MIB2_ENST00000378712.1_Missense_Mutation_p.E432K|MIB2_ENST00000360522.4_Missense_Mutation_p.E520K|MIB2_ENST00000378710.3_Missense_Mutation_p.E519K	NM_080875.2	NP_543151.2	Q96AX9	MIB2_HUMAN	mindbomb E3 ubiquitin protein ligase 2	555					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|lung(7)|prostate(4)|upper_aerodigestive_tract(1)	18	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GCCGGACGACGAGGGCAACAC	0.716000													4	35					0	0	1	0	0
ZNRF2	223082	broad.mit.edu	37	7	30395343	30395343	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:30395343G>A	ENST00000323037.4	+	3	1616		c.e3-1			NM_147128.3	NP_667339.1	Q8NHG8	ZNRF2_HUMAN	zinc and ring finger 2							cell junction|endosome membrane|lysosomal membrane|presynaptic membrane	ligase activity|zinc ion binding			breast(1)|endometrium(1)|lung(2)|prostate(1)	5						TCTTTCTTCAGAGGATGTACT	0.358000													14	41					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203690474	203690474	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:203690474G>C	ENST00000357681.5	+	17	3871	c.2748G>C	c.(2746-2748)atG>atC	p.M916I	ATP2B4_ENST00000367219.3_Missense_Mutation_p.M904I|ATP2B4_ENST00000391954.2_Missense_Mutation_p.M916I|ATP2B4_ENST00000367218.3_Missense_Mutation_p.M916I|ATP2B4_ENST00000341360.2_Missense_Mutation_p.M916I	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	916					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CACGCACTATGATGAAGAACA	0.532000													4	111					0	0	1	0	0
RIN2	54453	broad.mit.edu	37	20	19955883	19955883	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:19955883C>G	ENST00000255006.6	+	8	1510	c.1361C>G	c.(1360-1362)cCg>cGg	p.P454R	RIN2_ENST00000440354.2_Intron|RIN2_ENST00000484638.1_3'UTR	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	405					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						GAGGCCGCCCCGGGGGATTGC	0.731000													3	6					0	0	1	0	0
PGM3	5238	broad.mit.edu	37	6	83878990	83878990	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:83878990G>A	ENST00000513973.1	-	13	1708	c.1592C>T	c.(1591-1593)gCt>gTt	p.A531V	PGM3_ENST00000283977.4_Missense_Mutation_p.A450V|DOPEY1_ENST00000484282.1_Intron|PGM3_ENST00000506587.1_Missense_Mutation_p.A559V|PGM3_ENST00000512866.1_Missense_Mutation_p.A531V	NM_001199918.1|NM_015599.2	NP_001186847.1|NP_056414.1	O95394	AGM1_HUMAN	phosphoglucomutase 3	531					dolichol-linked oligosaccharide biosynthetic process|embryo development ending in birth or egg hatching|glucose 1-phosphate metabolic process|hemopoiesis|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity	p.A531D(1)		NS(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	18		all_cancers(76;0.000504)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.068)		BRCA - Breast invasive adenocarcinoma(397;0.0478)		AATTCCTCCAGCCAGCTGAAA	0.383000													7	70					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59989374	59989374	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:59989374C>T	ENST00000444766.3	-	6	806	c.731G>A	c.(730-732)aGg>aAg	p.R244K	INTS2_ENST00000251334.6_Missense_Mutation_p.R236K	NM_020748.2	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	244					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						TGTCCTGCGCCTTCCTCCAAG	0.428000													38	113					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96550112	96550112	+	Silent	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:96550112A>C	ENST00000456556.1	-	53	3252	c.3168T>G	c.(3166-3168)tcT>tcG	p.S1056S	ANKRD36C_ENST00000419039.2_Silent_p.S83S|ANKRD36C_ENST00000420871.2_Silent_p.S307S|ANKRD36C_ENST00000295246.5_Silent_p.S477S					ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GTCTCTGAGAAGACACTGAAA	0.323000													7	38					0	0	1	0	0
PPP4R1	9989	broad.mit.edu	37	18	9588829	9588829	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:9588829C>T	ENST00000400556.3	-	5	391	c.318G>A	c.(316-318)ctG>ctA	p.L106L	RP11-881L2.1_ENST00000584109.1_RNA|PPP4R1_ENST00000400555.3_Silent_p.L89L|PPP4R1_ENST00000580583.1_5'UTR	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	106					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			large_intestine(1)|skin(2)	3						CCTGTTCCATCAGCTCCGCTC	0.418000													17	55					0	0	1	0	0
ENTPD8	377841	broad.mit.edu	37	9	140330593	140330593	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:140330593C>T	ENST00000371506.2	-	7	1105	c.922G>A	c.(922-924)Gaa>Aaa	p.E308K	ENTPD8_ENST00000344119.2_Missense_Mutation_p.E308K|ENTPD8_ENST00000472938.1_Missense_Mutation_p.E308K	NM_001033113.1	NP_001028285.1	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	308						integral to membrane|plasma membrane	ATP binding			biliary_tract(1)|lung(4)|prostate(1)|skin(1)	7	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		CCTGTCCCTTCAACTGTGAGG	0.642000													9	29					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45873455	45873455	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:45873455T>C	ENST00000391945.4	-	2	118	c.41A>G	c.(40-42)tAc>tGc	p.Y14C	ERCC2_ENST00000221481.6_Missense_Mutation_p.Y14C|ERCC2_ENST00000485403.2_5'UTR|ERCC2_ENST00000391940.4_5'UTR|ERCC2_ENST00000391944.3_Missense_Mutation_p.Y14C	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	14	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding	p.Y14C(1)		large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GATGTAGTCGTACGGGAAGTA	0.682000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				6	38					0	0	1	0	0
RTN3	10313	broad.mit.edu	37	11	63525627	63525627	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:63525627G>A	ENST00000377819.5	+	9	3207		c.e9-1		RTN3_ENST00000354497.4_Splice_Site|RTN3_ENST00000537981.1_Splice_Site|RTN3_ENST00000341307.2_Splice_Site|RTN3_ENST00000339997.4_Splice_Site|RTN3_ENST00000540798.1_Splice_Site|RTN3_ENST00000356000.3_Splice_Site	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3						apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						TTTCTCAATAGGATCCAAGCA	0.363000													4	32					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48789562	48789562	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:48789562C>T	ENST00000316623.5	-	19	2649	c.2194G>A	c.(2194-2196)Gat>Aat	p.D732N		NM_000138.4	NP_000129	P35555	FBN1_HUMAN	fibrillin 1	732	EGF-like 11; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GGGCAAATATCAGGATCTAGT	0.323000													6	50					0	0	1	0	0
NSMCE1	197370	broad.mit.edu	37	16	27246532	27246532	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:27246532G>A	ENST00000361439.4	-	3	324	c.225C>T	c.(223-225)gtC>gtT	p.V75V		NM_145080.3	NP_659547.2	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog (S. cerevisiae)	75					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding			endometrium(2)|large_intestine(2)|lung(3)	7						CATCTTCCGTGACTCCTCTCT	0.493000											OREG0023693	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	23					0	0	1	0	0
ENC1	8507	broad.mit.edu	37	5	73931551	73931551	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:73931551C>T	ENST00000302351.4	-	2	1890	c.760G>A	c.(760-762)Gaa>Aaa	p.E254K	ENC1_ENST00000537006.1_Missense_Mutation_p.E254K|ENC1_ENST00000510316.1_Missense_Mutation_p.E181K	NM_003633.3	NP_003624.1	O14682	ENC1_HUMAN	ectodermal-neural cortex 1 (with BTB domain)	254					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	20		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		GTGATGAGTTCCTCCATGGCC	0.498000													13	37					0	0	1	0	0
PUM2	23369	broad.mit.edu	37	2	20508298	20508298	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:20508298C>T	ENST00000361078.2	-	5	588	c.566G>A	c.(565-567)cGc>cAc	p.R189H	PUM2_ENST00000536417.1_Missense_Mutation_p.R133H|PUM2_ENST00000403432.1_Missense_Mutation_p.R189H|PUM2_ENST00000420234.1_5'UTR|PUM2_ENST00000319801.5_Missense_Mutation_p.R189H|PUM2_ENST00000338086.5_Missense_Mutation_p.R189H			Q8TB72	PUM2_HUMAN	pumilio RNA-binding family member 2	189	Interaction with SNAPIN.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(7)|lung(13)|ovary(2)|prostate(4)|urinary_tract(3)	42	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGGCCCAAGCGCTCAACTAC	0.408000													29	86					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1651960	1651960	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:1651960G>A	ENST00000252804.4	-	17	3642	c.3592C>T	c.(3592-3594)Cgg>Tgg	p.R1198W		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1198			R -> Q (in dbSNP:rs6723697).		extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AGTTTCTCCCGGATCTCAGGG	0.517000													15	171					0	0	1	0	0
ZFP69B	65243	broad.mit.edu	37	1	40929203	40929203	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:40929203C>T	ENST00000411995.2	+	6	1922	c.1547C>T	c.(1546-1548)tCa>tTa	p.S516L	ZFP69B_ENST00000484445.1_3'UTR|ZFP69B_ENST00000361584.3_Missense_Mutation_p.S414L	NM_023070.2	NP_075558.2			ZFP69 zinc finger protein B																		AGCTGTAGTTCATCCCTTATT	0.353000													94	57					0	0	1	0	0
HMMR	3161	broad.mit.edu	37	5	162898429	162898429	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:162898429G>A	ENST00000393915.4	+	7	753	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K	HMMR_ENST00000358715.3_Missense_Mutation_p.E203K|HMMR_ENST00000432118.2_Missense_Mutation_p.E117K|HMMR_ENST00000353866.3_Missense_Mutation_p.E188K	NM_001142556.1|NM_012484.2	NP_001136028.1|NP_036616.2	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor (RHAMM)	203						cell surface|cytoplasm	hyaluronic acid binding			cervix(1)|kidney(3)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	23	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		AAGGAGTCTCGAAGAGTCTCA	0.418000													4	16					0	0	1	0	0
SKIV2L	6499	broad.mit.edu	37	6	31929373	31929373	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:31929373A>T	ENST00000375394.2	+	9	952	c.839A>T	c.(838-840)cAg>cTg	p.Q280L	SKIV2L_ENST00000544581.1_Missense_Mutation_p.Q87L	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	280						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						CCTCCATCTCAGGAGCAGTGG	0.577000													14	61					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47125627	47125627	+	Silent	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:47125627C>A	ENST00000409792.3	-	12	5685	c.5643G>T	c.(5641-5643)ctG>ctT	p.L1881L		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1881					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TTATAATTTTCAGTCTGCGAA	0.443000			"""N, F, S, Mis"""		clear cell renal carcinoma								19	185					1.38854e-25	1.46293e-25	1	1	0
UHRF2	115426	broad.mit.edu	37	9	6413598	6413598	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:6413598C>T	ENST00000276893.5	+	1	276	c.108C>T	c.(106-108)ttC>ttT	p.F36F	UHRF2_ENST00000381373.3_Silent_p.F36F	NM_152896.2	NP_690856.1	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase	36	Ubiquitin-like.				cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)	17		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		GGGCGCTGTTCGACGTGCGGC	0.672000													6	12					0	0	1	0	0
KIF12	113220	broad.mit.edu	37	9	116859977	116859977	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:116859977C>G	ENST00000374118.3	-	3	243	c.6G>C	c.(4-6)caG>caC	p.Q2H	KIF12_ENST00000473174.1_5'UTR	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	135					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						CGAAGGTCCTCTGCATGATGC	0.592000													12	16					0	0	1	0	0
ZNF785	146540	broad.mit.edu	37	16	30593976	30593976	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:30593976C>T	ENST00000395216.2	-	3	1282	c.1123G>A	c.(1123-1125)Gtg>Atg	p.V375M	AC002310.7_ENST00000486926.1_RNA|ZNF785_ENST00000470110.1_Missense_Mutation_p.V360M|AC002310.7_ENST00000492040.1_RNA	NM_152458.6	NP_689671.2	A8K8V0	ZN785_HUMAN	zinc finger protein 785	375					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9						CGCCCCACCACGGCCTGCTGC	0.617000													15	52					0	0	1	0	0
ZNF565	147929	broad.mit.edu	37	19	36685968	36685968	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:36685968C>T	ENST00000355114.5	-	3	946	c.220G>A	c.(220-222)Gtg>Atg	p.V74M	ZNF565_ENST00000304116.5_Missense_Mutation_p.V34M|ZNF565_ENST00000392173.2_Missense_Mutation_p.V34M			Q8N9K5	ZN565_HUMAN	zinc finger protein 565	34					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(4)|lung(4)|ovary(1)|skin(2)	11	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.206)			TCCAGAGTCACCTCCCTGTAC	0.522000													9	62					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22216514	22216514	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:22216514G>A	ENST00000374695.3	-	6	613	c.534C>T	c.(532-534)gtC>gtT	p.V178V		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	178	SEA.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGGGAGAGGTGACGTAGGAGG	0.617000													10	69					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8484233	8484233	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:8484233G>A	ENST00000381196.4	-	27	3842	c.3299C>T	c.(3298-3300)aCg>aTg	p.T1100M	PTPRD_ENST00000397611.3_Missense_Mutation_p.T686M|PTPRD_ENST00000355233.5_Missense_Mutation_p.T689M|PTPRD_ENST00000397606.3_Missense_Mutation_p.T679M|PTPRD_ENST00000358503.5_Missense_Mutation_p.T1078M|PTPRD_ENST00000360074.4_Missense_Mutation_p.T1087M|PTPRD_ENST00000540109.1_Missense_Mutation_p.T1100M|PTPRD_ENST00000356435.5_Missense_Mutation_p.T1100M|PTPRD_ENST00000537002.1_Missense_Mutation_p.T686M|PTPRD_ENST00000397617.3_Missense_Mutation_p.T679M|PTPRD_ENST00000486161.1_Missense_Mutation_p.T689M	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1100	Fibronectin type-III 8.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AGTCTTTGCCGTGACCCTGTG	0.483000										TSP Lung(15;0.13)			5	41					0	0	1	0	0
EID1	23741	broad.mit.edu	37	15	49170827	49170827	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:49170827G>A	ENST00000530028.2	+	1	745	c.454G>A	c.(454-456)Gag>Aag	p.E152K	EID1_ENST00000560490.1_Missense_Mutation_p.E130K|EID1_ENST00000558295.1_Intron|SHC4_ENST00000332408.4_Intron	NM_014335.2	NP_055150.1	Q9Y6B2	EID1_HUMAN	EP300 interacting inhibitor of differentiation 1	152					cell cycle|cell differentiation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	histone acetyltransferase binding|histone acetyltransferase regulator activity|transcription corepressor activity			liver(1)|prostate(1)	2		all_lung(180;0.00455)		all cancers(107;2.73e-08)|GBM - Glioblastoma multiforme(94;9.58e-07)		GATGCATTATGAGAAGACCCC	0.468000													13	22					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157527627	157527627	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:157527627C>T	ENST00000346085.5	+	20	5353	c.5352C>T	c.(5350-5352)ttC>ttT	p.F1784F	ARID1B_ENST00000367148.1_Silent_p.F1824F|ARID1B_ENST00000350026.5_Silent_p.F1771F|ARID1B_ENST00000275248.4_Silent_p.F1766F	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1771					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CCAGTAAGTTCGACAAGCTGC	0.512000													39	231					0	0	1	0	0
DUSP5	1847	broad.mit.edu	37	10	112266755	112266755	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:112266755C>T	ENST00000369583.3	+	3	875	c.591C>T	c.(589-591)tgC>tgT	p.C197C	DUSP5_ENST00000468749.1_3'UTR	NM_004419.3	NP_004410.3	Q16690	DUS5_HUMAN	dual specificity phosphatase 5	197	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			kidney(2)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	13		Breast(234;0.0848)		Epithelial(162;0.000276)|all cancers(201;0.00465)|BRCA - Breast invasive adenocarcinoma(275;0.12)		CATCCAAGTGCGAGTTCCTCG	0.557000													26	127					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118373680	118373680	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:118373680C>T	ENST00000534358.1	+	27	7096	c.7073C>T	c.(7072-7074)tCt>tTt	p.S2358F	KMT2A_ENST00000389506.5_Missense_Mutation_p.S2355F|KMT2A_ENST00000354520.4_Missense_Mutation_p.S2317F	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GCTGAACCCTCTTCAGTGTCG	0.458000													14	97					0	0	1	0	0
FAM217A	222826	broad.mit.edu	37	6	4068966	4068966	+	Silent	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:4068966A>C	ENST00000274673.3	-	7	1894	c.1491T>G	c.(1489-1491)gcT>gcG	p.A497A	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	497																	ACTTATCCTTAGCAATAAGGG	0.363000													6	50					0	0	1	0	0
AGK	55750	broad.mit.edu	37	7	141349062	141349062	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:141349062G>C	ENST00000355413.4	+	14	1235		c.e14-1		AGK_ENST00000535825.1_Splice_Site|AGK_ENST00000473247.1_Splice_Site	NM_018238.3	NP_060708.1	Q53H12	AGK_HUMAN	acylglycerol kinase						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(3)	17	Melanoma(164;0.0171)					AACCTTTTTAGAGCAAAGAAG	0.373000													4	32					0	0	1	0	0
FOXP4	116113	broad.mit.edu	37	6	41545790	41545790	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:41545790G>A	ENST00000373060.1	+	3	729	c.271G>A	c.(271-273)Gac>Aac	p.D91N	FOXP4_ENST00000373063.3_Missense_Mutation_p.D91N|FOXP4_ENST00000373057.3_Missense_Mutation_p.D91N|FOXP4_ENST00000307972.4_Missense_Mutation_p.D91N|FOXP4_ENST00000409208.1_Missense_Mutation_p.D91N	NM_001012426.1|NM_001012427.1	NP_001012426.1|NP_001012427.1	Q8IVH2	FOXP4_HUMAN	forkhead box P4	91	Gln-rich.				embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)					AGGGAACAATGACAGCAAACA	0.642000													4	13					0	0	1	0	0
KRT16	3868	broad.mit.edu	37	17	39766593	39766593	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:39766593C>T	ENST00000301653.4	-	6	1334	c.1270G>A	c.(1270-1272)Gag>Aag	p.E424K		NM_005557.3	NP_005548.2	P08779	K1C16_HUMAN	keratin 16	424	Coil 2.|Rod.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(137;0.000307)				TGGGCATCCTCGCCCTCCAGC	0.617000													8	68					0	0	1	0	0
SAMM50	25813	broad.mit.edu	37	22	44385046	44385046	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:44385046A>G	ENST00000350028.4	+	13	1288	c.1131A>G	c.(1129-1131)ccA>ccG	p.P377P	SAMM50_ENST00000396202.3_Silent_p.P167P	NM_015380.4	NP_056195.3	Q9Y512	SAM50_HUMAN	SAMM50 sorting and assembly machinery component	377					protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial sorting and assembly machinery complex	protein binding			endometrium(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				TCTACACCCCATTACCTTTCC	0.527000													20	72					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127755328	127755328	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:127755328C>T	ENST00000368679.4	-	13	1689	c.1380G>A	c.(1378-1380)ccG>ccA	p.P460P	ADAM12_ENST00000368676.4_Silent_p.P460P|ADAM12_ENST00000467145.1_5'UTR	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	460	Disintegrin.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		ACACAGCGTCCGGCTTCAGGG	0.552000													4	21					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64967302	64967302	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:64967302G>A	ENST00000399262.2	-	10	4345	c.4127C>T	c.(4126-4128)tCa>tTa	p.S1376L	JMJD1C_ENST00000399251.1_Missense_Mutation_p.S1157L|JMJD1C_ENST00000542921.1_Missense_Mutation_p.S1194L|JMJD1C_ENST00000402544.1_Missense_Mutation_p.S1157L	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	1376					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					ACTGCCCTGTGAGACAGCCTG	0.423000													18	120					0	0	1	0	0
CAMSAP2	23271	broad.mit.edu	37	1	200817712	200817712	+	Silent	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:200817712T>C	ENST00000358823.2	+	11	2085	c.1815T>C	c.(1813-1815)aaT>aaC	p.N605N	CAMSAP2_ENST00000236925.4_Silent_p.N616N|CAMSAP2_ENST00000413307.2_Silent_p.N589N	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	616						cytoplasm|microtubule	protein binding										TAACTGACAATACTGAAGTAG	0.363000													30	62					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160706495	160706495	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:160706495T>C	ENST00000263636.4	-	23	3173	c.3146A>G	c.(3145-3147)gAa>gGa	p.E1049G	LY75_ENST00000554112.1_Missense_Mutation_p.E1049G|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.E1049G|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.E1049G|LY75_ENST00000553424.1_Missense_Mutation_p.E1049G	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		ACTTACATTTTCTGGTATTCT	0.358000													7	80					0	0	1	0	0
TUBAL3	79861	broad.mit.edu	37	10	5436344	5436344	+	Silent	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:5436344G>C	ENST00000380419.3	-	4	514	c.477C>G	c.(475-477)ctC>ctG	p.L159L	TUBAL3_ENST00000479328.1_Silent_p.L119L	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	159					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						TCTCCATTAAGAGAGACGTAA	0.483000													9	69					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48420948	48420948	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:48420948C>G	ENST00000296438.5	+	7	860	c.674C>G	c.(673-675)tCt>tGt	p.S225C	FBXW12_ENST00000445170.1_Missense_Mutation_p.S206C|FBXW12_ENST00000436231.1_Missense_Mutation_p.S68C|FBXW12_ENST00000415155.1_Missense_Mutation_p.S155C	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	225										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGAGATGTTTCTAAAGTTACT	0.428000													29	163					0	0	1	0	0
ZFP36	7538	broad.mit.edu	37	19	39898696	39898696	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:39898696C>T	ENST00000597629.1	+	2	430	c.356C>T	c.(355-357)tCa>tTa	p.S119L	ZFP36_ENST00000248673.3_Missense_Mutation_p.S113L|ZFP36_ENST00000594045.1_3'UTR			P26651	TTP_HUMAN	ZFP36 ring finger protein	113					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			large_intestine(1)|lung(5)|pancreas(1)	7	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGGACCTTCTCAGAGAGTGGG	0.652000													8	87					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20691065	20691065	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:20691065T>C	ENST00000404938.2	+	13	2007	c.1355T>C	c.(1354-1356)aTc>aCc	p.I452T	ABCB5_ENST00000443026.2_Missense_Mutation_p.I7T|ABCB5_ENST00000258738.6_Missense_Mutation_p.I7T|ABCB5_ENST00000406935.1_Missense_Mutation_p.I7T|ABCB5_ENST00000477094.1_3'UTR	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	7	ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						GAGAATGACATCAGAGCTTTA	0.393000													13	31					0	0	1	0	0
NUPL2	11097	broad.mit.edu	37	7	23224762	23224762	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:23224762A>T	ENST00000258742.5	+	2	454	c.195A>T	c.(193-195)aaA>aaT	p.K65N	AC005082.1_ENST00000366347.4_Intron|NUPL2_ENST00000410002.3_Missense_Mutation_p.K65N|NUPL2_ENST00000487595.1_3'UTR	NM_007342.2	NP_031368.1	O15504	NUPL2_HUMAN	nucleoporin like 2	65					carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GTTTCTCCAAATCCACACCAT	0.393000													20	35					0	0	1	0	0
OMG	4974	broad.mit.edu	37	17	29623198	29623198	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:29623198G>A	ENST00000247271.4	-	2	413	c.152C>T	c.(151-153)tCt>tTt	p.S51F	NF1_ENST00000358273.4_Intron|NF1_ENST00000356175.3_Intron	NM_002544.4	NP_002535.3	P23515	OMGP_HUMAN	oligodendrocyte myelin glycoprotein	51	LRRNT.				cell adhesion|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|plasma membrane		p.0?(8)|p.?(3)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)|stomach(1)	13		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;1.81e-13)|Epithelial(4;4.04e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.49e-12)|GBM - Glioblastoma multiforme(4;0.121)		TTGCAGTCCAGATGGTAATGT	0.413000													8	55					0	0	1	0	0
MYNN	55892	broad.mit.edu	37	3	169504460	169504460	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:169504460A>G	ENST00000349841.5	+	8	2490	c.1827A>G	c.(1825-1827)ttA>ttG	p.L609L	MYNN_ENST00000544106.1_Silent_p.L580L|MYNN_ENST00000356716.4_Silent_p.L609L	NM_018657.4	NP_061127.1	Q9NPC7	MYNN_HUMAN	myoneurin	609						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TACAACAATTATACTGACTTT	0.353000													11	50					0	0	1	0	0
SLC7A7	9056	broad.mit.edu	37	14	23282502	23282502	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:23282502C>T	ENST00000397532.3	-	2	631	c.106G>A	c.(106-108)Gag>Aag	p.E36K	SLC7A7_ENST00000554517.1_Intron|SLC7A7_ENST00000397529.2_Missense_Mutation_p.E36K|SLC7A7_ENST00000555702.1_Missense_Mutation_p.E36K|SLC7A7_ENST00000397528.4_Missense_Mutation_p.E36K|SLC7A7_ENST00000285850.7_Missense_Mutation_p.E36K			Q9UM01	YLAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7	36			Missing (in LPI; failed to induce cationic amino acid transport activity).		blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		AGTGAGATCTCCTTCTTCAGC	0.572000													8	42					0	0	1	0	0
ZNF526	116115	broad.mit.edu	37	19	42728598	42728598	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:42728598A>C	ENST00000301215.3	+	3	268	c.43A>C	c.(43-45)Atg>Ctg	p.M15L		NM_133444.1	NP_597701.1	Q8TF50	ZN526_HUMAN	zinc finger protein 526	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(3)	22		Prostate(69;0.0704)				GCCAACACAGATGTCACCAGG	0.577000													11	58					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44117968	44117968	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:44117968G>T	ENST00000259746.9	+	17	1711	c.1528G>T	c.(1528-1530)Gag>Tag	p.E510*	TMEM63B_ENST00000323267.6_Nonsense_Mutation_p.E510*			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	510						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CAGCTCTGGGGAGAACAGGAC	0.587000													5	27					0.014758	0.014863	1	1	0
ZNF793	390927	broad.mit.edu	37	19	38028268	38028268	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:38028268C>T	ENST00000445217.1	+	4	743	c.708C>T	c.(706-708)ttC>ttT	p.F236F	ZNF793_ENST00000588578.1_3'UTR|ZNF793_ENST00000587143.1_Silent_p.F236F|ZNF793_ENST00000542455.1_Silent_p.F236F|ZNF793_ENST00000589319.1_Intron			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	236					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGAAAGCCTTCTGCTACAAGT	0.458000													3	27					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160282926	160282926	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:160282926C>A	ENST00000241704.7	-	10	1103	c.874G>T	c.(874-876)Gat>Tat	p.D292Y	COPA_ENST00000368069.3_Missense_Mutation_p.D292Y	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	292					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CAGAAACGATCATGGTCTCTG	0.403000													5	38					0.00116845	0.00118603	1	1	0
BEST3	144453	broad.mit.edu	37	12	70049497	70049497	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:70049497C>T	ENST00000330891.5	-	10	1423	c.1197G>A	c.(1195-1197)ctG>ctA	p.L399L	BEST3_ENST00000553096.1_Silent_p.L293L|BEST3_ENST00000331471.4_Intron|BEST3_ENST00000488961.1_Silent_p.L186L	NM_001282613.1|NM_032735.2	NP_001269542.1|NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	399						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CGTGGGCACTCAGGAACCGCT	0.557000													821	80					0	0	1	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799168	57799168	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:57799168C>T	ENST00000302622.3	+	1	767	c.744C>T	c.(742-744)caC>caT	p.H248H	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	248					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				GTGCAGCTCACCTGACTGTGG	0.512000													14	68					0	0	1	0	0
PDGFRL	5157	broad.mit.edu	37	8	17486204	17486204	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:17486204C>G	ENST00000541323.1	+	5	1159	c.714C>G	c.(712-714)tcC>tcG	p.S238S	PDGFRL_ENST00000251630.6_Silent_p.S238S|PDGFRL_ENST00000398074.3_Silent_p.S238S	NM_006207.2	NP_006198.1	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	238						extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	9				Colorectal(111;0.0752)		AACCTCATTCCGAGCACCAGG	0.572000													7	36					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145557131	145557131	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:145557131G>A	ENST00000394434.2	-	2	270	c.104C>T	c.(103-105)tCt>tTt	p.S35F	LARS_ENST00000510191.1_Intron|LARS_ENST00000545646.1_Missense_Mutation_p.S35F|LARS_ENST00000511505.1_5'UTR|LARS_ENST00000274562.9_Missense_Mutation_p.S35F	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	35					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CTCTAAATTAGATGCATTGAC	0.294000													7	60					0	0	1	0	0
PPP1R26	9858	broad.mit.edu	37	9	138376625	138376625	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:138376625A>G	ENST00000356818.2	+	4	818	c.269A>G	c.(268-270)cAc>cGc	p.H90R	PPP1R26_ENST00000401470.3_Missense_Mutation_p.H90R|PPP1R26_ENST00000604351.1_Missense_Mutation_p.H90R|PPP1R26_ENST00000605660.1_Missense_Mutation_p.H90R|PPP1R26_ENST00000605286.1_Missense_Mutation_p.H90R|PPP1R26_ENST00000602993.1_Intron	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	90						nucleolus	protein binding										CCCACCGTGCACAAGGAGCCA	0.657000													7	32					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577574	7577574	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:7577574T>C	ENST00000420246.2	-	7	839	c.707A>G	c.(706-708)tAc>tGc	p.Y236C	TP53_ENST00000413465.2_Missense_Mutation_p.Y236C|TP53_ENST00000445888.2_Missense_Mutation_p.Y236C|TP53_ENST00000269305.4_Missense_Mutation_p.Y236C|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000455263.2_Missense_Mutation_p.Y236C|TP53_ENST00000359597.4_Missense_Mutation_p.Y236C	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	236	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y236C(61)|p.0?(8)|p.?(5)|p.Y143C(5)|p.Y236del(4)|p.Y236S(3)|p.Y236_M237delYM(1)|p.I232_Y236delIHYNY(1)|p.H233fs*6(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.Y236fs*4(1)|p.H233_C242del10(1)|p.N235_Y236delNY(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTACACATGTAGTTGTAGTG	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	35					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73015432	73015432	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:73015432G>T	ENST00000261180.4	+	15	2537	c.2441G>T	c.(2440-2442)cGt>cTt	p.R814L		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	814					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding	p.R814H(1)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						AGAGAACTACGTAGAGAAGTT	0.348000													6	163					3.59834e-05	3.68153e-05	1	1	0
YIPF3	25844	broad.mit.edu	37	6	43479936	43479936	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:43479936T>A	ENST00000372422.2	-	9	1204	c.1022A>T	c.(1021-1023)aAa>aTa	p.K341I	YIPF3_ENST00000506469.1_Missense_Mutation_p.K347I	NM_015388.3	NP_056203.2	Q9GZM5	YIPF3_HUMAN	Yip1 domain family, member 3	341					cell differentiation	integral to membrane|plasma membrane|transport vesicle				large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)	9	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			CGCAACAGCTTTGGCTGTGGC	0.602000													17	52					0	0	1	0	0
ZNF644	84146	broad.mit.edu	37	1	91406796	91406796	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:91406796T>C	ENST00000370440.1	-	3	332	c.115A>G	c.(115-117)Aaa>Gaa	p.K39E	ZNF644_ENST00000361321.5_Intron|ZNF644_ENST00000347275.5_Intron|ZNF644_ENST00000337393.5_Missense_Mutation_p.K39E|ZNF644_ENST00000467231.1_Intron			Q9H582	ZN644_HUMAN	zinc finger protein 644	39					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AGTTCTTCTTTAGCACCAGTA	0.313000													30	122					0	0	1	0	0
MAZ	4150	broad.mit.edu	37	16	29819575	29819575	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:29819575C>T	ENST00000219782.6	+	3	1174	c.1068C>T	c.(1066-1068)gtC>gtT	p.V356V	MAZ_ENST00000563402.1_Intron|MAZ_ENST00000568544.1_5'UTR|MAZ_ENST00000569978.1_5'UTR|MAZ_ENST00000566906.2_Intron|MAZ_ENST00000322945.6_Silent_p.V356V|MAZ_ENST00000562337.1_Intron|MAZ_ENST00000568282.1_5'UTR|MAZ_ENST00000545521.1_Silent_p.V333V	NM_001042539.1	NP_001036004.1	P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	356					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						ACAGTCACGTCAGACAAGTGC	0.562000													8	35					0	0	1	0	0
SNX27	81609	broad.mit.edu	37	1	151638466	151638466	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:151638466G>A	ENST00000368843.3	+	6	1084	c.964G>A	c.(964-966)Gaa>Aaa	p.E322K	SNX27_ENST00000482791.1_3'UTR|SNX27_ENST00000368838.1_Missense_Mutation_p.E229K|SNX27_ENST00000458013.2_Missense_Mutation_p.E322K	NM_030918.5	NP_112180.4	Q96L92	SNX27_HUMAN	sorting nexin family member 27	322	Ras-associating.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			central_nervous_system(1)|large_intestine(2)|ovary(2)	5	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGCCTTATTTGAAGTGATCAG	0.373000													24	69					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179452256	179452256	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:179452256A>T	ENST00000589042.1	-	306	64004	c.63780T>A	c.(63778-63780)aaT>aaA	p.N21260K	TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.N12387K|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.N19619K|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.N18692K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.N12320K|TTN_ENST00000460472.2_Missense_Mutation_p.N12195K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19619	Fibronectin type-III 54.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATACTCTGACATTTACGAATA	0.403000													4	24					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2040330	2040330	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:2040330A>G	ENST00000262113.4	+	16	2126	c.1985A>G	c.(1984-1986)aAg>aGg	p.K662R	MYOM2_ENST00000523438.1_Missense_Mutation_p.K87R	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	662	Fibronectin type-III 3.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TGCAACCACAAGCCCATTGGA	0.627000													5	36					0	0	1	0	0
MASTL	84930	broad.mit.edu	37	10	27459243	27459243	+	Missense_Mutation	SNP	C	C	G	rs148839815		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:27459243C>G	ENST00000375946.4	+	8	1958	c.1355C>G	c.(1354-1356)tCc>tGc	p.S452C	MASTL_ENST00000342386.6_Missense_Mutation_p.S452C|MASTL_ENST00000477034.1_3'UTR|MASTL_ENST00000375940.4_Missense_Mutation_p.S452C	NM_001172303.1|NM_032844.3	NP_001165774.1|NP_116233.2	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine kinase-like	452	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			breast(3)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TTGGTTGACTCCAGTCCTTGT	0.338000													13	42					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7456754	7456754	+	Silent	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:7456754A>C	ENST00000486284.1	+	5	1352	c.1078A>C	c.(1078-1080)Aga>Cga	p.R360R	GRM7_ENST00000402647.2_Silent_p.R360R|GRM7_ENST00000357716.4_Silent_p.R360R|GRM7_ENST00000403881.1_Silent_p.R360R|GRM7_ENST00000389336.4_Silent_p.R360R	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	360					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding	p.R360R(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	AAACAACAGAAGAAATGTATG	0.428000													4	71					0	0	1	0	0
PPEF1	5475	broad.mit.edu	37	X	18802022	18802022	+	Silent	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:18802022T>C	ENST00000361511.4	+	12	1262	c.768T>C	c.(766-768)caT>caC	p.H256H	PPEF1_ENST00000544635.1_Silent_p.H191H|PPEF1_ENST00000359763.6_Silent_p.H203H|PPEF1_ENST00000349874.5_Silent_p.H256H|PPEF1_ENST00000543630.1_Silent_p.H256H	NM_006240.2|NM_152224.1	NP_006231.2|NP_689410.1	O14829	PPE1_HUMAN	protein phosphatase, EF-hand calcium binding domain 1	256	Catalytic.				detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	43	Hepatocellular(33;0.183)					TACAGCTACATGGAAAAAGAA	0.388000													21	32					0	0	1	0	0
FRG2B	441581	broad.mit.edu	37	10	135440191	135440191	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:135440191G>C	ENST00000443774.1	-	1	105	c.56C>G	c.(55-57)aCt>aGt	p.T19S	FRG2B_ENST00000425520.1_Missense_Mutation_p.T19S			Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	19						nucleus				endometrium(2)|kidney(2)|lung(14)|ovary(1)|prostate(1)	20		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GGGCTGGTCAGTGGAGCACTG	0.507000													7	158					0	0	1	0	0
TCF3	6929	broad.mit.edu	37	19	1615435	1615435	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:1615435C>T	ENST00000262965.5	-	18	2015	c.1671G>A	c.(1669-1671)cgG>cgA	p.R557R	TCF3_ENST00000395423.3_Silent_p.R561R|TCF3_ENST00000588136.1_Intron|TCF3_ENST00000344749.5_Intron|TCF3_ENST00000453954.2_Intron	NM_003200.3	NP_003191.1	P15923	TFE2_HUMAN	transcription factor 3	557					B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGCCGCTCCCGGGCGTTAT	0.657000			T	"""PBX1, HLF, TFPT"""	pre B-ALL								22	100					0	0	1	0	0
DPH2	1802	broad.mit.edu	37	1	44437320	44437320	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:44437320C>T	ENST00000255108.3	+	4	918	c.746C>T	c.(745-747)tCc>tTc	p.S249F	DPH2_ENST00000412950.2_Missense_Mutation_p.S114F|DPH2_ENST00000396758.2_Intron|DPH2_ENST00000529729.1_3'UTR	NM_001384.4	NP_001375.2	Q9BQC3	DPH2_HUMAN	DPH2 homolog (S. cerevisiae)	249					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(2)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				CCCTTCTCCTCCTGCTGTCCA	0.617000													13	54					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146243906	146243906	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:146243906C>T	ENST00000367503.3	-	19	4022	c.3624G>A	c.(3622-3624)caG>caA	p.Q1208Q	SHPRH_ENST00000367505.2_Silent_p.Q1204Q|SHPRH_ENST00000275233.7_Silent_p.Q1204Q|SHPRH_ENST00000438092.2_Silent_p.Q1208Q	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	1204					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TTACTAGCTTCTGGCATTTAT	0.458000													4	54					0	0	1	0	0
ZIK1	284307	broad.mit.edu	37	19	58101627	58101627	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:58101627G>A	ENST00000597850.1	+	4	663	c.448G>A	c.(448-450)Gac>Aac	p.D150N	ZIK1_ENST00000536878.2_Missense_Mutation_p.D137N|ZIK1_ENST00000599456.1_Missense_Mutation_p.D95N|ZIK1_ENST00000307468.4_3'UTR	NM_001010879.2	NP_001010879.2	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein 1	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	34		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GAGGGACATGGACAGAGCCTC	0.483000													6	47					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18837130	18837130	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:18837130G>C	ENST00000447925.2	-	14	1938	c.1669C>G	c.(1669-1671)Caa>Gaa	p.Q557E	PLCZ1_ENST00000435379.1_Missense_Mutation_p.Q364E|PLCZ1_ENST00000539875.1_Missense_Mutation_p.Q366E|PLCZ1_ENST00000541695.1_3'UTR|PLCZ1_ENST00000534932.1_Missense_Mutation_p.Q40E|PLCZ1_ENST00000266505.7_Missense_Mutation_p.Q559E|PLCZ1_ENST00000538330.1_Missense_Mutation_p.Q341E	NM_033123.3	NP_149114.2	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	559	C2.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					ATTAAACCTTGACCTTCAACA	0.338000													5	54					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7583313	7583313	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:7583313G>A	ENST00000379802.3	+	24	6159	c.5818G>A	c.(5818-5820)Gat>Aat	p.D1940N	DSP_ENST00000418664.2_Missense_Mutation_p.D1341N	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1940	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GAGGGAGATTGATAAACTCAG	0.517000													5	43					0	0	1	0	0
ETV1	2115	broad.mit.edu	37	7	13971367	13971367	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:13971367G>A	ENST00000343495.5	-	8	1246	c.508C>T	c.(508-510)Cgc>Tgc	p.R170C	ETV1_ENST00000420159.2_Missense_Mutation_p.R130C|ETV1_ENST00000403685.1_Missense_Mutation_p.R170C|ETV1_ENST00000405358.4_Missense_Mutation_p.R202C|ETV1_ENST00000399357.3_Missense_Mutation_p.R85C|ETV1_ENST00000242066.5_Missense_Mutation_p.R170C|ETV1_ENST00000430479.1_Missense_Mutation_p.R188C|ETV1_ENST00000405218.2_Missense_Mutation_p.R188C|ETV1_ENST00000403527.1_Missense_Mutation_p.R148C|ETV1_ENST00000405192.2_Missense_Mutation_p.R188C|ETV1_ENST00000476720.2_5'UTR			P50549	ETV1_HUMAN	ets variant 1	188					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						GAAAGCTGGCGGCGAAATCTA	0.458000			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								3	32					0	0	1	0	0
WRAP53	55135	broad.mit.edu	37	17	7592162	7592162	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:7592162G>A	ENST00000316024.5	+	1	2544	c.196G>A	c.(196-198)Gag>Aag	p.E66K	WRAP53_ENST00000457584.2_Missense_Mutation_p.E66K|WRAP53_ENST00000431639.2_Missense_Mutation_p.E66K|WRAP53_ENST00000396463.2_Missense_Mutation_p.E66K|WRAP53_ENST00000534050.1_Missense_Mutation_p.E66K			Q9BUR4	WAP53_HUMAN	WD repeat containing, antisense to TP53	66					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(2)	18						TGTGTCCCAGGAGCTACGGGA	0.577000													6	116					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063771	9063771	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:9063771G>A	ENST00000397910.4	-	3	23878	c.23675C>T	c.(23674-23676)tCt>tTt	p.S7892F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7894	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGGGATGTAGAGAACCAGCT	0.498000													12	73					0	0	1	0	0
PROZ	8858	broad.mit.edu	37	13	113825987	113825987	+	Silent	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:113825987G>T	ENST00000342783.4	+	9	844	c.837G>T	c.(835-837)gcG>gcT	p.A279A	PROZ_ENST00000375547.2_Silent_p.A257A	NM_001256134.1	NP_001243063.1	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma glycoprotein	257	Peptidase S1.				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity			NS(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(4)|prostate(2)|skin(2)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	ACGCGGACGCGGGGGAGAATG	0.572000													14	52					2.62699e-14	2.75134e-14	1	1	0
KIF14	9928	broad.mit.edu	37	1	200549457	200549457	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:200549457C>T	ENST00000367350.4	-	21	3828	c.3390G>A	c.(3388-3390)ctG>ctA	p.L1130L		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	1130	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						TTCCTAGTTTCAGGTTACGAA	0.313000													26	53					0	0	1	0	0
PUSL1	126789	broad.mit.edu	37	1	1246026	1246026	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:1246026C>T	ENST00000379031.5	+	6	734	c.657C>T	c.(655-657)ttC>ttT	p.F219F	PUSL1_ENST00000470520.1_3'UTR	NM_153339.1	NP_699170.1	Q8N0Z8	PUSL1_HUMAN	pseudouridylate synthase-like 1	219					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			lung(3)|skin(1)|urinary_tract(1)	5	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGCTGCGGTTCTGGAACCTGG	0.592000													15	169					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60381640	60381640	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:60381640G>C	ENST00000371204.3	-	2	386	c.343C>G	c.(343-345)Cct>Gct	p.P115A		NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	115					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					TCTCGCATAGGGGTCACGGGG	0.433000													13	115					0	0	1	0	0
BAMBI	25805	broad.mit.edu	37	10	28970327	28970327	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:28970327C>T	ENST00000375533.3	+	2	773	c.217C>T	c.(217-219)Ctt>Ttt	p.L73F		NM_012342.2	NP_036474.1	Q13145	BAMBI_HUMAN	BMP and activin membrane-bound inhibitor	73					cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of protein binding|positive regulation of transcription, DNA-dependent|regulation of cell shape	cytoplasm|integral to membrane|plasma membrane	frizzled binding|type II transforming growth factor beta receptor binding	p.L73F(1)		central_nervous_system(5)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)	17						CCTGGACTCTCTTGCAAGCAC	0.498000													11	86					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138978697	138978697	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:138978697C>T	ENST00000473989.3	+	17	3964	c.3964C>T	c.(3964-3966)Ctg>Ttg	p.L1322L	UBN2_ENST00000288561.8_Silent_p.L1239L	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2											NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						CCACTCACCTCTGCCTGCACA	0.433000													15	44					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117788639	117788639	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:117788639G>A	ENST00000276204.6	+	43	4844	c.4770G>A	c.(4768-4770)atG>atA	p.M1590I	DOCK11_ENST00000276202.7_Missense_Mutation_p.M1590I			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1590	DHR-2.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						CTGCCCAAATGAAGGAGCATG	0.448000													25	38					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52759296	52759296	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:52759296G>C	ENST00000287727.3	+	11	3369	c.3197G>C	c.(3196-3198)tGg>tCg	p.W1066S	ZFYVE9_ENST00000371591.1_Missense_Mutation_p.W1066S|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.W1007S			O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	1066					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						GAAACTCCTTGGGCTAAAGTA	0.403000													26	95					0	0	1	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28271869	28271869	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:28271869T>C	ENST00000373894.3	+	2	379	c.188T>C	c.(187-189)cTc>cCc	p.L63P	SMPDL3B_ENST00000373888.4_Missense_Mutation_p.L63P|SMPDL3B_ENST00000549094.1_Missense_Mutation_p.L63P|SMPDL3B_ENST00000466793.1_3'UTR|RP11-460I13.2_ENST00000448015.1_RNA	NM_014474.2	NP_055289.2	Q92485	ASM3B_HUMAN	sphingomyelin phosphodiesterase, acid-like 3B	63					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	16		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		GGTGACTACCTCTGTGATTCT	0.567000													8	48					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33527309	33527309	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:33527309T>G	ENST00000504830.1	-	24	5104	c.4769A>C	c.(4768-4770)aAg>aCg	p.K1590T	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.K1505T	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1590					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TTCTTTTGACTTTTGGAGCAA	0.537000										HNSCC(64;0.19)			10	162					0	0	1	0	0
SRGAP1	57522	broad.mit.edu	37	12	64488945	64488945	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:64488945C>G	ENST00000355086.3	+	14	2163	c.1639C>G	c.(1639-1641)Cag>Gag	p.Q547E	SRGAP1_ENST00000357825.3_Missense_Mutation_p.Q524E|RP11-196H14.2_ENST00000535594.1_RNA|SRGAP1_ENST00000543397.1_Missense_Mutation_p.Q484E	NM_020762.2	NP_065813.1	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	547	Rho-GAP.				axon guidance	cytosol				breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	65			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		GTCTGGTTCCCAGGTGGAAGT	0.403000													4	84					0	0	1	0	0
MTMR14	64419	broad.mit.edu	37	3	9695324	9695324	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:9695324G>A	ENST00000296003.4	+	2	301	c.179G>A	c.(178-180)aGa>aAa	p.R60K	MTMR14_ENST00000420925.1_Intron|MTMR14_ENST00000353332.5_Missense_Mutation_p.R60K|MTMR14_ENST00000351233.5_Missense_Mutation_p.R60K	NM_001077525.2	NP_001070993.1	Q8NCE2	MTMRE_HUMAN	myotubularin related protein 14	60						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(2)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	21	Medulloblastoma(99;0.227)					ATTGAGAAGAGATGTCTGGAG	0.517000													41	111					0	0	1	0	0
ZIK1	284307	broad.mit.edu	37	19	58102093	58102093	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:58102093G>A	ENST00000597850.1	+	4	1129	c.914G>A	c.(913-915)aGa>aAa	p.R305K	ZIK1_ENST00000536878.2_Missense_Mutation_p.R292K|ZIK1_ENST00000599456.1_Missense_Mutation_p.R250K|ZIK1_ENST00000307468.4_3'UTR	NM_001010879.2	NP_001010879.2	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein 1	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	34		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAATTATTTAGACAAAACTCC	0.453000													14	77					0	0	1	0	0
AP1M2	10053	broad.mit.edu	37	19	10692498	10692498	+	Silent	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:10692498G>C	ENST00000590923.1	-	4	407	c.324C>G	c.(322-324)gtC>gtG	p.V108V	AP1M2_ENST00000250244.6_Silent_p.V108V			Q9Y6Q5	AP1M2_HUMAN	adaptor-related protein complex 1, mu 2 subunit	108					cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			endometrium(4)|large_intestine(1)|lung(1)|ovary(2)|urinary_tract(1)	9			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CGTAGACGATGACAAAGTTGT	0.562000													3	16					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27306626	27306626	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:27306626C>T	ENST00000376087.4	-	30	4476	c.4311G>A	c.(4309-4311)atG>atA	p.M1437I	ANKRD26_ENST00000436985.2_Missense_Mutation_p.M1453I|ANKRD26_ENST00000376070.3_Missense_Mutation_p.M994I	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1436						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						GTACTGTTTTCATAGATAACA	0.343000													11	39					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7636546	7636546	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:7636546C>A	ENST00000572933.1	+	5	2001	c.541C>A	c.(541-543)Cct>Act	p.P181T	DNAH2_ENST00000082259.3_Missense_Mutation_p.P181T|DNAH2_ENST00000389173.2_Missense_Mutation_p.P181T|DNAH2_ENST00000570791.1_Missense_Mutation_p.P181T			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	181	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGTCTTTGCCCCTCAGATCTT	0.552000													4	86					0.00909568	0.00918651	1	1	0
ATF7IP	55729	broad.mit.edu	37	12	14577324	14577324	+	Missense_Mutation	SNP	C	C	A	rs150179759		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:14577324C>A	ENST00000544627.1	+	2	819	c.499C>A	c.(499-501)Ccc>Acc	p.P167T	ATF7IP_ENST00000536444.1_Missense_Mutation_p.P159T|ATF7IP_ENST00000261168.4_Missense_Mutation_p.P159T|ATF7IP_ENST00000543189.1_Missense_Mutation_p.P159T|ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000540793.1_Missense_Mutation_p.P159T			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	159					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						CTCTGGTGATCCCACCTCTAG	0.597000													9	51					0.0581538	0.0584427	1	1	0
IQGAP1	8826	broad.mit.edu	37	15	91020346	91020346	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:91020346C>T	ENST00000268182.5	+	25	3112	c.2988C>T	c.(2986-2988)aaC>aaT	p.N996N	IQGAP1_ENST00000560738.1_Silent_p.N424N	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	996	C1.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TGCCCCAGAACAAGTCCACCA	0.468000													19	104					0	0	1	0	0
SPPL3	121665	broad.mit.edu	37	12	121205312	121205312	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:121205312G>A	ENST00000353487.2	-	9	1361	c.858C>T	c.(856-858)gaC>gaT	p.D286D		NM_139015.4	NP_620584.2	Q8TCT6	PSL4_HUMAN	signal peptide peptidase like 3	287						integral to membrane	aspartic-type endopeptidase activity					all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TTTTGTAGTTGTCATAGCGAA	0.547000													8	42					0	0	1	0	0
PAX7	5081	broad.mit.edu	37	1	18960999	18960999	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:18960999C>T	ENST00000420770.2	+	2	371	c.288C>T	c.(286-288)atC>atT	p.I96I	PAX7_ENST00000400661.3_Silent_p.I96I|PAX7_ENST00000375375.3_Silent_p.I96I	NM_001135254.1	NP_001128726.1	P23759	PAX7_HUMAN	paired box 7	96	Paired.				anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		CCGGGTCCATCCGGCCTGGGG	0.652000			T	FOXO1A	alveolar rhabdomyosarcoma								4	42					0	0	1	0	0
ACTR8	93973	broad.mit.edu	37	3	53904098	53904098	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:53904098G>A	ENST00000335754.3	-	12	1742	c.1642C>T	c.(1642-1644)Caa>Taa	p.Q548*	ACTR8_ENST00000482349.1_Nonsense_Mutation_p.Q437*|ACTR8_ENST00000488802.1_5'UTR|ACTR8_ENST00000231909.7_Nonsense_Mutation_p.Q253*	NM_022899.4	NP_075050.3	Q9H981	ARP8_HUMAN	ARP8 actin-related protein 8 homolog (yeast)	548					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		AGAAATTCTTGAGCTTTATGA	0.423000													24	106					0	0	1	0	0
NOP9	161424	broad.mit.edu	37	14	24771532	24771532	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:24771532G>A	ENST00000267425.3	+	5	1138	c.1045G>A	c.(1045-1047)Gag>Aag	p.E349K	NOP9_ENST00000396802.3_Missense_Mutation_p.E349K	NM_174913.1	NP_777573.1			NOP9 nucleolar protein																		GAGCCTCTTTGAGGAGCACTT	0.582000													30	100					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117246779	117246779	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:117246779T>C	ENST00000003084.6	+	18	3092	c.2960T>C	c.(2959-2961)cTg>cCg	p.L987P	AC000111.6_ENST00000456270.1_RNA|CFTR_ENST00000454343.1_Missense_Mutation_p.L926P	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	987	ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GATGACCTTCTGCCTCTTACC	0.279000									Cystic Fibrosis				12	159					0	0	1	0	0
RUNX1	861	broad.mit.edu	37	21	36259214	36259214	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:36259214C>T	ENST00000344691.4	-	1	1773	c.196G>A	c.(196-198)Gac>Aac	p.D66N	RUNX1_ENST00000325074.5_Missense_Mutation_p.D81N|RUNX1_ENST00000300305.3_Missense_Mutation_p.D93N|RUNX1_ENST00000437180.1_Missense_Mutation_p.D93N|RUNX1_ENST00000486278.2_Missense_Mutation_p.D69N|RUNX1_ENST00000358356.5_Missense_Mutation_p.D66N|RUNX1_ENST00000399240.1_Missense_Mutation_p.D66N	NM_001001890.2	NP_001001890.1	Q01196	RUNX1_HUMAN	runt-related transcription factor 1	66	Runt.				myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|calcium ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.V90_K117del(1)		breast(5)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(428)|large_intestine(3)|lung(6)|oesophagus(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	452						TTGGGGCTGTCGGTGCGCACC	0.706000			T	"""RPL22, MDS1, EVI1, CBFA2T3, CBFA2T1, ETV6, LAF4"""	"""AML, preB- ALL, T-ALL"""								9	27					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129324858	129324858	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:129324858C>T	ENST00000393239.1	-	1	803	c.625G>A	c.(625-627)Gtg>Atg	p.V209M	PLXND1_ENST00000324093.4_Missense_Mutation_p.V209M			Q9Y4D7	PLXD1_HUMAN	plexin D1	209	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						GTGGCGCCCACGAGCAGGCGG	0.706000													3	15					0	0	1	0	0
GMPR	2766	broad.mit.edu	37	6	16290809	16290809	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:16290809G>A	ENST00000259727.4	+	8	928	c.814G>A	c.(814-816)Gac>Aac	p.D272N	GMPR_ENST00000544145.1_3'UTR	NM_006877.3	NP_006868.3	P36959	GMPR1_HUMAN	guanosine monophosphate reductase	272					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage|response to cold	cytosol	GMP reductase activity|metal ion binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	20	Breast(50;0.0427)|Ovarian(93;0.103)	all_hematologic(90;0.0895)				GATGAGCTCTGACACCGCCAT	0.572000													93	64					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42477158	42477158	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:42477158C>G	ENST00000434000.1	-	9	2335	c.2053G>C	c.(2053-2055)Gag>Cag	p.E685Q	GPATCH8_ENST00000591680.1_Missense_Mutation_p.E763Q			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	763	Lys-rich.					intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		CTGCTCCCCTCTTCAGCTGGG	0.582000													8	85					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1083991	1083991	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:1083991G>A	ENST00000264930.5	-	8	1041	c.998C>T	c.(997-999)tCa>tTa	p.S333L		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	333					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GGAGGTGGCTGAGTTGTTGTG	0.652000													4	48					0	0	1	0	0
ZNF34	80778	broad.mit.edu	37	8	145999073	145999073	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:145999073A>G	ENST00000429371.2	-	6	1351	c.1198T>C	c.(1198-1200)Tgt>Cgt	p.C400R	ZNF34_ENST00000343459.4_Missense_Mutation_p.C421R	NM_030580.3	NP_085057.3	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	421					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		CATTCATTACATTTATAGGGT	0.408000													12	29					0	0	1	0	0
RBM4B	83759	broad.mit.edu	37	11	66436538	66436538	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:66436538C>T	ENST00000525754.1	-	2	1305	c.637G>A	c.(637-639)Gat>Aat	p.D213N	RBM4B_ENST00000524637.1_3'UTR|RBM4B_ENST00000531969.1_Intron|RBM4B_ENST00000310046.4_Missense_Mutation_p.D213N			Q9BQ04	RBM4B_HUMAN	RNA binding motif protein 4B	213	Interaction with TNPO3 (By similarity).				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(4)|lung(1)|urinary_tract(2)	10						CCATATGCATCGTTGTAATAC	0.507000													4	52					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52790748	52790748	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:52790748G>A	ENST00000257974.2	-	6	1064	c.987C>T	c.(985-987)ctC>ctT	p.L329L	RP3-416H24.4_ENST00000547174.1_RNA	NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	329	Coil 2.|Rod.					keratin filament	protein binding|structural constituent of epidermis			endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		TACGGTTGCGGAGGTTGTCAC	0.552000													18	21					0	0	1	0	0
SPATA32	124783	broad.mit.edu	37	17	43333141	43333141	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:43333141G>A	ENST00000543122.1	-	6	1126	c.345C>T	c.(343-345)ttC>ttT	p.F115F	MAP3K14-AS1_ENST00000588504.1_RNA|MAP3K14-AS1_ENST00000590100.1_RNA|SPATA32_ENST00000331780.4_Silent_p.F136F|MAP3K14-AS1_ENST00000588698.1_RNA|MAP3K14-AS1_ENST00000585346.1_RNA|MAP3K14-AS1_ENST00000588160.1_RNA|MAP3K14-AS1_ENST00000592422.1_RNA|MAP3K14-AS1_ENST00000591263.1_RNA					spermatogenesis associated 32									p.F136F(1)									TCTCCTCCGTGAAACTCCGGC	0.567000													20	85					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51949710	51949710	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:51949710G>A	ENST00000371117.3	-	2	297	c.22C>T	c.(22-24)Ctg>Ttg	p.L8L	PKHD1_ENST00000340994.4_Silent_p.L8L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	8					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					ATACTCATCAGAGAGATCAGC	0.358000													9	126					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7662380	7662380	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:7662380C>A	ENST00000572933.1	+	15	3846	c.2386C>A	c.(2386-2388)Cac>Aac	p.H796N	DNAH2_ENST00000389173.2_Missense_Mutation_p.H796N			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	796	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GATGAACCTGCACCAGGATGT	0.498000													15	26					6.31663e-08	6.53826e-08	1	1	0
PPP1R36	145376	broad.mit.edu	37	14	65053915	65053915	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:65053915T>G	ENST00000298705.1	+	10	811	c.715T>G	c.(715-717)Ttt>Gtt	p.F239V	RP11-973N13.3_ENST00000556634.1_RNA|RP11-973N13.3_ENST00000554454.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	239																	GTTGTAGTCCTTTTATACTTT	0.388000													3	37					0	0	1	0	0
EFCAB14	9813	broad.mit.edu	37	1	47183663	47183663	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:47183663G>A	ENST00000371933.3	-	1	1073	c.97C>T	c.(97-99)Cgc>Tgc	p.R33C	EFCAB14_ENST00000544071.1_Missense_Mutation_p.R33C	NM_014774.2	NP_055589.1			EF-hand calcium binding domain 14																		GGCTCAGTGCGAAGCAGGCGG	0.532000													5	51					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502632	90502632	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:90502632C>T	ENST00000325643.5	+	4	3296	c.3230C>T	c.(3229-3231)tCa>tTa	p.S1077L		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GGTAACCCCTCAGCGTCTTCA	0.577000													12	42					0	0	1	0	0
SYCE1	93426	broad.mit.edu	37	10	135369391	135369391	+	Silent	SNP	C	C	G	rs139237056		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:135369391C>G	ENST00000368517.3	-	10	642	c.504G>C	c.(502-504)gcG>gcC	p.A168A	SYCE1_ENST00000343131.5_Silent_p.A204A|SYCE1_ENST00000432597.2_Silent_p.A168A|SPRN_ENST00000541506.1_Intron	NM_130784.2	NP_570140.1	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	204					cell division	central element				breast(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|stomach(3)|urinary_tract(1)	19		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CTTCCAGTGTCGCCTTGACCA	0.597000													4	31					0	0	1	0	0
CYR61	3491	broad.mit.edu	37	1	86048174	86048174	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:86048174C>T	ENST00000451137.2	+	4	934	c.710C>T	c.(709-711)tCc>tTc	p.S237F		NM_001554.4	NP_001545.2	O00622	CYR61_HUMAN	cysteine-rich, angiogenic inducer, 61	237	TSP type-1.				cell proliferation|chemotaxis|positive regulation of BMP signaling pathway|positive regulation of cell migration|positive regulation of osteoblast differentiation|positive regulation of osteoblast proliferation|positive regulation of protein kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell growth|regulation of ERK1 and ERK2 cascade|wound healing, spreading of cells	extracellular region	heparin binding|insulin-like growth factor binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|prostate(1)	5				all cancers(265;0.0216)|Epithelial(280;0.0441)		ACTTCATGGTCCCAGTGCTCA	0.468000											OREG0013583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	69					0	0	1	0	0
FBXO43	286151	broad.mit.edu	37	8	101146122	101146122	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:101146122C>T	ENST00000428847.2	-	5	2351	c.2035G>A	c.(2035-2037)Gaa>Aaa	p.E679K		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	679					meiosis		zinc ion binding	p.E645Q(2)|p.E679Q(1)		endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			CTACATTCTTCAGACCCATGA	0.453000													133	73					0	0	1	0	0
FAM117B	150864	broad.mit.edu	37	2	203630305	203630305	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:203630305A>C	ENST00000303116.6	+	8	1598	c.856A>C	c.(856-858)Aag>Cag	p.K286Q	FAM117B_ENST00000392238.2_Missense_Mutation_p.K530Q	NM_173511.3	NP_775782.2	Q6P1L5	F117B_HUMAN	family with sequence similarity 117, member B	530								p.K286*(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)	17						TCTTACACTCAAGGGCTCTGG	0.522000													16	92					0	0	1	0	0
TMED4	222068	broad.mit.edu	37	7	44620713	44620713	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:44620713C>T	ENST00000457408.2	-	4	565	c.513G>A	c.(511-513)caG>caA	p.Q171Q	TMED4_ENST00000444131.2_5'UTR|TMED4_ENST00000481238.1_Silent_p.Q171Q|TMED4_ENST00000289577.5_Intron	NM_182547.2	NP_872353.2	Q7Z7H5	TMED4_HUMAN	transmembrane emp24 protein transport domain containing 4	171					positive regulation of I-kappaB kinase/NF-kappaB cascade|transport	endoplasmic reticulum membrane|integral to membrane	signal transducer activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)	6						CCTGCTCCTTCTGAATCTGTT	0.493000													11	29					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184099309	184099309	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:184099309G>A	ENST00000204604.1	+	4	654	c.408G>A	c.(406-408)ccG>ccA	p.P136P	CHRD_ENST00000348986.3_Silent_p.P136P|CHRD_ENST00000450923.1_Silent_p.P136P|EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000482805.1_3'UTR	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	136					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding	p.P136P(1)		NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGCGGCAGCCGAGCGGCCTGT	0.697000													3	19					0	0	1	0	0
C3orf58	205428	broad.mit.edu	37	3	143691520	143691520	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:143691520C>T	ENST00000315691.3	+	1	881	c.346C>T	c.(346-348)Cgc>Tgc	p.R116C	C3orf58_ENST00000493396.1_3'UTR	NM_173552.3	NP_775823.1	Q8NDZ4	CC058_HUMAN	chromosome 3 open reading frame 58	116						COPI vesicle coat|extracellular region				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CGGCTCGCAGCGCGAGCTGGC	0.721000													11	14					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54159117	54159117	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:54159117G>C	ENST00000404125.1	-	10	1226	c.1171C>G	c.(1171-1173)Caa>Gaa	p.Q391E	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	391					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GTAACATCTTGATCAGTAAGC	0.443000													15	38					0	0	1	0	0
SEPP1	6414	broad.mit.edu	37	5	42801094	42801094	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:42801094C>T	ENST00000514985.1	-	5	1130	c.874G>A	c.(874-876)Gat>Aat	p.D292N	CCDC152_ENST00000361970.5_3'UTR|SEPP1_ENST00000507920.1_3'UTR|SEPP1_ENST00000509276.1_5'UTR|SEPP1_ENST00000511224.1_Missense_Mutation_p.D292N|SEPP1_ENST00000506577.1_Missense_Mutation_p.D292N	NM_005410.2	NP_005401.3	P49908	SEPP1_HUMAN	selenoprotein P, plasma, 1	292					response to oxidative stress	extracellular region	selenium binding			kidney(10)|large_intestine(1)|lung(4)	15						AACTCTGAATCTGTGGGCAAT	0.408000													24	61					0	0	1	0	0
HIST1H3H	8357	broad.mit.edu	37	6	27778143	27778143	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:27778143G>A	ENST00000369163.2	+	1	302	c.292G>A	c.(292-294)Gag>Aag	p.E98K		NM_003536.2	NP_003527.1	P68431	H31_HUMAN	histone cluster 1, H3h	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)|upper_aerodigestive_tract(3)	10						AGAGGCATGCGAGGCCTACCT	0.602000													13	23					0	0	1	0	0
SIRPD	128646	broad.mit.edu	37	20	1532451	1532451	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:1532451G>A	ENST00000381623.3	-	2	1496	c.307C>T	c.(307-309)Cgc>Tgc	p.R103C	SIRPD_ENST00000381621.1_Missense_Mutation_p.R103C			Q9H106	SIRPD_HUMAN	signal-regulatory protein delta	103	Ig-like V-type.					extracellular region				breast(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)	15						TCACGGATGCGGGTGGAAAAG	0.458000													17	75					0	0	1	0	0
ZNF649	65251	broad.mit.edu	37	19	52400201	52400201	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:52400201C>G	ENST00000354957.3	-	3	330	c.46G>C	c.(46-48)Gac>Cac	p.D16H	CTC-429C10.2_ENST00000600329.1_RNA|ZNF649_ENST00000600738.1_Missense_Mutation_p.D16H	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	16	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CAGGTGAAGTCCACAGCCACA	0.483000													27	136					0	0	1	0	0
CAGE1	285782	broad.mit.edu	37	6	7374133	7374133	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:7374133C>T	ENST00000502583.1	-	5	1483	c.919G>A	c.(919-921)Gaa>Aaa	p.E307K	CAGE1_ENST00000338150.4_Missense_Mutation_p.E307K|CAGE1_ENST00000379918.4_Missense_Mutation_p.E307K|CAGE1_ENST00000512086.1_Missense_Mutation_p.E307K|CAGE1_ENST00000296742.7_Missense_Mutation_p.E171K	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	307										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					TGCAAGACTTCATTTAAAGCC	0.428000													5	43					0	0	1	0	0
KIFC2	90990	broad.mit.edu	37	8	145697757	145697757	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:145697757C>T	ENST00000301332.2	+	15	1998	c.1621C>T	c.(1621-1623)Cca>Tca	p.P541S	KIFC2_ENST00000531423.1_3'UTR|KIFC2_ENST00000301331.5_Intron	NM_145754.2	NP_665697.1	Q96AC6	KIFC2_HUMAN	kinesin family member C2	541	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(3)|prostate(3)|skin(2)|urinary_tract(1)	19	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CCTCCTTGCTCCAGGGCCTCC	0.672000													5	16					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72143604	72143604	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:72143604G>A	ENST00000356056.5	-	37	7043	c.6571C>T	c.(6571-6573)Cat>Tat	p.H2191Y	MYO9A_ENST00000444904.1_Missense_Mutation_p.H2172Y|MYO9A_ENST00000564571.1_Missense_Mutation_p.H2191Y|MYO9A_ENST00000424560.1_Missense_Mutation_p.H2262Y	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	2191	Rho-GAP.|Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						CTGACTAGATGAAAGATGAGG	0.388000													24	88					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120462993	120462993	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:120462993C>T	ENST00000256646.2	-	30	5557	c.5338G>A	c.(5338-5340)Gaa>Aaa	p.E1780K		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1780					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGTCATCTTCTTCTGAGAGT	0.532000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				18	73					0	0	1	0	0
ANKRD29	147463	broad.mit.edu	37	18	21181263	21181263	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:21181263A>C	ENST00000592179.1	-	10	987	c.833T>G	c.(832-834)cTt>cGt	p.L278R	ANKRD29_ENST00000284207.7_Missense_Mutation_p.L245R|ANKRD29_ENST00000322980.9_Missense_Mutation_p.L245R	NM_173505.2	NP_775776.2	Q8N6D5	ANR29_HUMAN	ankyrin repeat domain 29	278										breast(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)	13	all_cancers(21;5.07e-05)|all_epithelial(16;2.49e-07)|Lung NSC(20;0.00211)|all_lung(20;0.00676)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TTCTGCCGGAAGTTCATTGGC	0.438000													5	39					0	0	1	0	0
MROH1	727957	broad.mit.edu	37	8	145254055	145254055	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:145254055C>T	ENST00000528919.1	+	10	1100	c.979C>T	c.(979-981)Ctg>Ttg	p.L327L	MROH1_ENST00000527071.1_3'UTR|MROH1_ENST00000534366.1_Silent_p.L327L|MROH1_ENST00000398656.4_Silent_p.L327L|MROH1_ENST00000326134.5_Silent_p.L327L|MROH1_ENST00000423230.2_Silent_p.L327L	NM_032450.2	NP_115826			maestro heat-like repeat family member 1																		CTCAAGCCCCCTGGTGATGAG	0.592000													7	21					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44804988	44804988	+	Silent	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:44804988C>A	ENST00000309315.4	+	16	2175	c.2052C>A	c.(2050-2052)ccC>ccA	p.P684P	ZMIZ2_ENST00000413916.1_Silent_p.P626P|ZMIZ2_ENST00000441627.1_Silent_p.P684P|ZMIZ2_ENST00000433667.1_Silent_p.P652P|ZMIZ2_ENST00000265346.7_Silent_p.P658P	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	684					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						AGCCAGTGCCCGTGAAGCCTG	0.642000													10	27					2.17888e-05	2.23087e-05	1	1	0
SLC26A8	116369	broad.mit.edu	37	6	35945031	35945031	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:35945031G>A	ENST00000490799.1	-	9	1476	c.1123C>T	c.(1123-1125)Ctg>Ttg	p.L375L	SLC26A8_ENST00000394602.2_Silent_p.L270L|SLC26A8_ENST00000355574.2_Silent_p.L375L	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	375					cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						TTCTTGCCCAGAAATATGAGC	0.413000													7	29					0	0	1	0	0
PHYHD1	254295	broad.mit.edu	37	9	131696081	131696081	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:131696081G>C	ENST00000372592.3	+	5	1146	c.213G>C	c.(211-213)ttG>ttC	p.L71F	PHYHD1_ENST00000421063.2_Missense_Mutation_p.L71F|PHYHD1_ENST00000353176.5_Missense_Mutation_p.L71F|PHYHD1_ENST00000308941.5_Missense_Mutation_p.L71F	NM_001100876.1	NP_001094346.1			phytanoyl-CoA dioxygenase domain containing 1											central_nervous_system(1)|endometrium(2)|large_intestine(3)|skin(1)|stomach(3)	10						ACTATTTCTTGAGCAGTGGTG	0.547000											OREG0003917	type=REGULATORY REGION|Gene=AK130919|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	12	102					0	0	1	0	0
CLSTN1	22883	broad.mit.edu	37	1	9804541	9804541	+	Silent	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:9804541G>C	ENST00000377298.4	-	8	1938	c.1146C>G	c.(1144-1146)ccC>ccG	p.P382P	CLSTN1_ENST00000377288.3_Silent_p.P382P|CLSTN1_ENST00000361311.4_Silent_p.P372P	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1	382					homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		ACGGCTCTTTGGGGCTGACCG	0.562000													5	47					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129742843	129742843	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:129742843G>C	ENST00000446488.3	-	22	2802	c.2699C>G	c.(2698-2700)tCt>tGt	p.S900C	NFRKB_ENST00000524746.1_Missense_Mutation_p.S900C|NFRKB_ENST00000524794.1_Missense_Mutation_p.S925C|NFRKB_ENST00000304521.5_Missense_Mutation_p.S900C	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	900					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		ACTGGGAGCAGAGGTCCCAGG	0.597000													3	42					0	0	1	0	0
STK36	27148	broad.mit.edu	37	2	219544431	219544431	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:219544431G>T	ENST00000295709.3	+	8	1206	c.927G>T	c.(925-927)atG>atT	p.M309I	STK36_ENST00000392106.2_Missense_Mutation_p.M309I|STK36_ENST00000440309.1_Missense_Mutation_p.M309I|STK36_ENST00000392105.3_Missense_Mutation_p.M309I	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	309					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		ATAAACGCATGGCTGAGGAGG	0.547000													14	36					9.16793e-09	9.50351e-09	1	1	0
SH2D7	646892	broad.mit.edu	37	15	78393815	78393815	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:78393815C>T	ENST00000328828.5	+	5	1220	c.1220C>T	c.(1219-1221)tCa>tTa	p.S407L	SH2D7_ENST00000409568.2_Missense_Mutation_p.S271L	NM_001101404.1	NP_001094874.1	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	407										endometrium(2)|kidney(2)|lung(3)	7						AAGAGGATCTCAGGGACCCCA	0.587000													4	12					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32770833	32770833	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:32770833T>C	ENST00000421745.2	+	63	12850	c.12716T>C	c.(12715-12717)tTg>tCg	p.L4239S		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4239					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CGGATGGCATTGGAAATTGGA	0.478000													3	70					0	0	1	0	0
AP5M1	55745	broad.mit.edu	37	14	57736066	57736066	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:57736066G>A	ENST00000261558.3	+	1	440	c.34G>A	c.(34-36)Gaa>Aaa	p.E12K	AP5M1_ENST00000431972.2_Missense_Mutation_p.E12K	NM_018229.3	NP_060699.3	Q9H0R1	MUDEN_HUMAN	adaptor-related protein complex 5, mu 1 subunit	12					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex											CATAAGCCACGAACCGGGAAC	0.502000													7	73					0	0	1	0	0
CORO1A	11151	broad.mit.edu	37	16	30199780	30199780	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:30199780C>G	ENST00000219150.5	+	10	1469	c.1164C>G	c.(1162-1164)ctC>ctG	p.L388L	CORO1A_ENST00000565497.1_Intron|CORO1A_ENST00000570045.1_Silent_p.L388L	NM_001193333.2|NM_007074.3	NP_001180262.1|NP_009005.1	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	388					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	9						CTGGGCCCCTCCTCATCTCCC	0.692000													11	44					0	0	1	0	0
MBNL3	55796	broad.mit.edu	37	X	131573563	131573563	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:131573563C>T	ENST00000370857.3	-	1	142	c.77G>A	c.(76-78)gGa>gAa	p.G26E	MBNL3_ENST00000370839.3_Missense_Mutation_p.G26E|MBNL3_ENST00000370853.3_Missense_Mutation_p.G26E|MBNL3_ENST00000370844.1_5'UTR			Q9NUK0	MBNL3_HUMAN	muscleblind-like splicing regulator 3	26					mRNA processing|multicellular organismal development|regulation of RNA splicing|RNA splicing	Golgi apparatus|nucleus	nucleic acid binding|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)	16	Acute lymphoblastic leukemia(192;0.000127)					AGAGCAAGTTCCTCTCTGAAA	0.433000													20	82					0	0	1	0	0
WDR36	134430	broad.mit.edu	37	5	110428132	110428132	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:110428132G>A	ENST00000506538.2	+	1	719	c.146G>A	c.(145-147)aGa>aAa	p.R49K	WDR36_ENST00000513710.2_Missense_Mutation_p.R49K|WDR36_ENST00000505303.1_5'UTR	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	49					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		CCAGAGCTGAGAGGAGCTGGG	0.617000													10	29					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14837150	14837150	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrY:14837150G>A	ENST00000338981.3	+	6	1375	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	144					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CTGGAAGTTTGAAATTCATGT	0.348000													11	26					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139662002	139662002	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:139662002G>A	ENST00000263552.6	+	13	1645	c.1107G>A	c.(1105-1107)ctG>ctA	p.L369L	TBXAS1_ENST00000448866.1_Silent_p.L368L|TBXAS1_ENST00000458722.1_Silent_p.L414L|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000425687.1_Silent_p.L301L|TBXAS1_ENST00000414508.2_Silent_p.L369L|TBXAS1_ENST00000416849.2_Silent_p.L415L|TBXAS1_ENST00000336425.5_Silent_p.L368L|TBXAS1_ENST00000436047.2_Silent_p.L369L|TBXAS1_ENST00000411653.1_Silent_p.L368L	NM_001130966.2	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	368					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					AGAAGCTTCTGAGAGAGGTAG	0.458000													8	21					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76495137	76495137	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:76495137C>T	ENST00000389840.5	-	37	5780	c.5656G>A	c.(5656-5658)Gag>Aag	p.E1886K	DNAH17_ENST00000585328.1_Missense_Mutation_p.E1895K|RP11-559N14.5_ENST00000591373.1_RNA|DNAH17-AS1_ENST00000598378.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CGATTAAACTCGTCAAAGCAG	0.587000													9	23					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13755838	13755838	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:13755838A>G	ENST00000202816.1	-	4	1221	c.1114T>C	c.(1114-1116)Ttt>Ctt	p.F372L		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TTGGGTTTAAATGAATTGAAC	0.308000													23	85					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47040207	47040207	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:47040207C>T	ENST00000450053.3	+	23	3401	c.3222C>T	c.(3220-3222)agC>agT	p.S1074S	NBEAL2_ENST00000292309.5_Splice_Site_p.S1074S|NBEAL2_ENST00000383740.2_5'UTR	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1074							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GACCTGCCAGCCCGCAGCGGG	0.692000											OREG0015546	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	6					0	0	1	0	0
SPRED2	200734	broad.mit.edu	37	2	65540838	65540838	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:65540838G>A	ENST00000356388.4	-	6	1243	c.1054C>T	c.(1054-1056)Cac>Tac	p.H352Y	SPRED2_ENST00000443619.2_Missense_Mutation_p.H349Y	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	352	SPR.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding	p.H352Y(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						GACATACAGTGATAGAGCATG	0.607000													13	52					0	0	1	0	0
LAMTOR2	28956	broad.mit.edu	37	1	156025192	156025192	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:156025192C>G	ENST00000368305.4	+	2	345	c.207C>G	c.(205-207)ctC>ctG	p.L69L	LAMTOR2_ENST00000368302.3_Silent_p.L69L|LAMTOR2_ENST00000489664.1_3'UTR|LAMTOR2_ENST00000368304.5_Silent_p.L69L	NM_014017.3	NP_054736.1	Q9Y2Q5	LTOR2_HUMAN	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	69	Required for location at endosomes (By similarity).				cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosomal membrane|Ragulator complex				breast(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	7						AAGACAATCTCAAATTCATCC	0.587000													10	58					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20819315	20819315	+	Silent	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:20819315G>C	ENST00000328879.4	-	4	1098	c.942C>G	c.(940-942)ctC>ctG	p.L314L	KLHL22_ENST00000440659.2_Silent_p.L171L	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	314					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CCTGGTCGCTGAGGACAGTGG	0.637000													7	198					0	0	1	0	0
TAP2	6891	broad.mit.edu	37	6	32784730	32784730	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:32784730C>T	ENST00000452392.2	-	12	2106		c.e12-1		HLA-DOB_ENST00000438763.2_5'UTR			Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)						antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding										AGAACCCATTCTGGAGAAAGG	0.458000													4	34					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	23689501	23689501	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:23689501T>A	ENST00000546136.1	-	13	1837	c.1835A>T	c.(1834-1836)tAc>tTc	p.Y612F	SOX5_ENST00000545921.1_Missense_Mutation_p.Y615F|SOX5_ENST00000537393.1_Missense_Mutation_p.Y590F|SOX5_ENST00000309359.1_Missense_Mutation_p.Y612F|SOX5_ENST00000541536.1_Missense_Mutation_p.Y504F|SOX5_ENST00000451604.2_Missense_Mutation_p.Y625F|SOX5_ENST00000381381.2_Missense_Mutation_p.Y504F|SOX5_ENST00000396007.2_Missense_Mutation_p.Y239F			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	625					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						CCTGGGCTTGTACTTATAGTC	0.527000													11	83					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82836783	82836783	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:82836783C>G	ENST00000265077.3	+	8	8526	c.7961C>G	c.(7960-7962)tCa>tGa	p.S2654*	VCAN_ENST00000342785.4_Intron|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000343200.5_Nonsense_Mutation_p.S1667*|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000512590.2_Intron|VCAN_ENST00000502527.2_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2654	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CATGATGAATCAATGACTTAT	0.433000													25	40					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6128366	6128366	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:6128366C>T	ENST00000261405.5	-	28	4472	c.4218G>A	c.(4216-4218)aaG>aaA	p.K1406K		NM_000552.3	NP_000543	P04275	VWF_HUMAN	von Willebrand factor	1406	VWFA 1; binding site for platelet glycoprotein Ib.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TGACCTTCTTCTTCTTCAGGC	0.617000													13	52					0	0	1	0	0
AKAP8	10270	broad.mit.edu	37	19	15472544	15472544	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:15472544G>C	ENST00000269701.2	-	11	1452	c.1392C>G	c.(1390-1392)ttC>ttG	p.F464L		NM_005858.3	NP_005849.1	O43823	AKAP8_HUMAN	A kinase (PRKA) anchor protein 8	464					signal transduction	nuclear matrix				breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)	26						ACTCACCTTTGAAAGGATCTG	0.478000													9	80					0	0	1	0	0
ESYT2	57488	broad.mit.edu	37	7	158560447	158560447	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:158560447G>A	ENST00000251527.5	-	8	1031	c.966C>T	c.(964-966)atC>atT	p.I322I		NM_020728.2	NP_065779.1	A0FGR8	ESYT2_HUMAN	extended synaptotagmin-like protein 2	350						integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(16)|prostate(2)	32						TATCCAAAATGATAGTATCTG	0.408000													6	54					0	0	1	0	0
ZNF597	146434	broad.mit.edu	37	16	3490853	3490853	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:3490853G>A	ENST00000301744.4	-	3	349	c.114C>T	c.(112-114)ctC>ctT	p.L38L		NM_152457.1	NP_689670.1	Q96LX8	ZN597_HUMAN	zinc finger protein 597	38	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	13						CATCTTTGCTGAGGGACCTCT	0.473000													10	98					0	0	1	0	0
KIF12	113220	broad.mit.edu	37	9	116858471	116858471	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:116858471G>A	ENST00000374118.3	-	6	578	c.341C>T	c.(340-342)tCt>tTt	p.S114F	KIF12_ENST00000473174.1_Intron	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	247	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						AGGGTCCACAGAAGGCATCTG	0.592000													4	25					0	0	1	0	0
ATE1	11101	broad.mit.edu	37	10	123670540	123670540	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:123670540C>T	ENST00000369043.3	-	5	550	c.464G>A	c.(463-465)gGa>gAa	p.G155E	ATE1_ENST00000535655.1_5'UTR|ATE1_ENST00000224652.6_Missense_Mutation_p.G155E|ATE1_ENST00000369040.3_Missense_Mutation_p.G59E|ATE1_ENST00000540606.1_Missense_Mutation_p.G148E|ATE1_ENST00000543447.1_Missense_Mutation_p.G40E	NM_007041.2	NP_008972.2	O95260	ATE1_HUMAN	arginyltransferase 1	155					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				TGAATTTTTTCCTTCACTCTC	0.383000													72	74					0	0	1	0	0
CD46	4179	broad.mit.edu	37	1	207940415	207940415	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:207940415A>C	ENST00000358170.2	+	6	887	c.731A>C	c.(730-732)aAa>aCa	p.K244T	CD46_ENST00000361067.1_Missense_Mutation_p.K244T|CD46_ENST00000441839.2_Missense_Mutation_p.K244T|CD46_ENST00000469535.1_3'UTR|CD46_ENST00000354848.1_Missense_Mutation_p.K244T|CD46_ENST00000360212.2_Missense_Mutation_p.K244T|CD46_ENST00000367041.1_Missense_Mutation_p.K244T|CD46_ENST00000480003.1_Missense_Mutation_p.K244T|CD46_ENST00000322875.4_Missense_Mutation_p.K244T|CD46_ENST00000367042.1_Missense_Mutation_p.K244T|CD46_ENST00000367047.1_Missense_Mutation_p.K181T|CD46_ENST00000357714.1_Missense_Mutation_p.K244T|CD46_ENST00000322918.5_Missense_Mutation_p.K244T	NM_002389.4	NP_002380.3	P15529	MCP_HUMAN	CD46 molecule, complement regulatory protein	244	Sushi 4.				complement activation, classical pathway|innate immune response|interspecies interaction between organisms|single fertilization	inner acrosomal membrane|integral to plasma membrane	protein binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	19						GGATTTGGAAAAAAATTTTAC	0.363000													7	40					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7580747	7580747	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:7580747C>T	ENST00000379802.3	+	23	4665	c.4324C>T	c.(4324-4326)Cag>Tag	p.Q1442*	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1442	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGAGGTGTCTCAGAGGAAACA	0.483000													3	42					0	0	1	0	0
ZNF652	22834	broad.mit.edu	37	17	47394737	47394737	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:47394737G>A	ENST00000362063.2	-	2	669	c.351C>T	c.(349-351)atC>atT	p.I117I	ZNF652_ENST00000430262.2_Silent_p.I117I	NM_014897.2	NP_055712.1	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	117	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			CCTCCACTATGATCTGCTCCC	0.428000													15	86					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54782181	54782181	+	Silent	SNP	G	G	A	rs1045821		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:54782181G>A	ENST00000391748.1	-	7	1318	c.1191C>T	c.(1189-1191)taC>taT	p.Y397Y	LILRB2_ENST00000314446.5_Silent_p.Y397Y|LILRB2_ENST00000391746.1_Silent_p.Y397Y|LILRB2_ENST00000391749.4_Silent_p.Y397Y|LILRB2_ENST00000434421.1_Silent_p.Y281Y	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	397	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGAGTGAGCCGTAGCACCTGT	0.592000													22	95					0	0	1	0	0
ZC3H13	23091	broad.mit.edu	37	13	46559704	46559704	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:46559704C>T	ENST00000242848.4	-	10	1796	c.1448G>A	c.(1447-1449)aGa>aAa	p.R483K	ZC3H13_ENST00000282007.3_Missense_Mutation_p.R483K			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	483	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		GCTATAATCTCTCATCTCCCT	0.522000													9	131					0	0	1	0	0
SYNE3	161176	broad.mit.edu	37	14	95903307	95903307	+	Silent	SNP	T	T	C	rs76499929	by1000genomes	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:95903307T>C	ENST00000334258.5	-	14	2402	c.2388A>G	c.(2386-2388)ctA>ctG	p.L796L	SYNE3_ENST00000557275.1_Intron|SYNE3_ENST00000554873.1_Silent_p.L553L	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3									p.L796delL(1)		breast(1)|endometrium(2)|lung(25)	28						CTTCTTCCTGTAGAAGATTTG	0.537000													7	42					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101551122	101551122	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:101551122G>A	ENST00000536262.2	-	15	2326	c.1768C>T	c.(1768-1770)Cct>Tct	p.P590S		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	590					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TTGAAAGCAGGATTATCAGTT	0.383000													4	26					0	0	1	0	0
CCRN4L	25819	broad.mit.edu	37	4	139964271	139964271	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:139964271C>G	ENST00000280614.2	+	2	427	c.234C>G	c.(232-234)ctC>ctG	p.L78L	ELF2_ENST00000515489.1_Intron	NM_012118.2	NP_036250.2	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like (S. cerevisiae)	78					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			kidney(2)|large_intestine(3)|lung(3)|ovary(1)	9	all_hematologic(180;0.162)					ATAGTGCTCTCGCCAAGACAC	0.517000													13	28					0	0	1	0	0
SNX7	51375	broad.mit.edu	37	1	99225664	99225664	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:99225664G>A	ENST00000370189.5	+	9	1352	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K	SNX7_ENST00000306121.3_Missense_Mutation_p.E445K|SNX7_ENST00000529992.1_Missense_Mutation_p.E390K			Q9UNH6	SNX7_HUMAN	sorting nexin 7	381					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	13		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		TCACTTGGAAGAAGCCTCTGA	0.408000													4	55					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47755190	47755190	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:47755190A>G	ENST00000360380.3	-	10	1303	c.940T>C	c.(940-942)Tat>Cat	p.Y314H	STIL_ENST00000371877.3_Missense_Mutation_p.Y314H|STIL_ENST00000396221.2_Missense_Mutation_p.Y314H|STIL_ENST00000337817.5_Missense_Mutation_p.Y314H|STIL_ENST00000243182.6_Missense_Mutation_p.Y314H	NM_001282936.1	NP_001269865.1	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	314					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				AAGCATTCATAAAACTCAGGT	0.323000													11	52					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41542802	41542802	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:41542802C>G	ENST00000263253.7	+	11	3332	c.2113C>G	c.(2113-2115)Cga>Gga	p.R705G		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	705					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						GATGATGCCTCGAATAACTCC	0.398000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				4	36					0	0	1	0	0
GSDMD	79792	broad.mit.edu	37	8	144643266	144643266	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:144643266C>G	ENST00000526406.1	+	8	1557	c.674C>G	c.(673-675)tCt>tGt	p.S225C	GSDMD_ENST00000533063.1_Missense_Mutation_p.S273C|GSDMD_ENST00000262580.4_Missense_Mutation_p.S225C	NM_001166237.1	NP_001159709.1	P57764	GSDMD_HUMAN	gasdermin D	225										breast(1)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	12						GTTATTGACTCTGACTTGGGT	0.657000													7	25					0	0	1	0	0
CPD	1362	broad.mit.edu	37	17	28770959	28770959	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:28770959G>A	ENST00000225719.4	+	11	2589	c.2513G>A	c.(2512-2514)gGa>gAa	p.G838E	CPD_ENST00000543464.2_Missense_Mutation_p.G591E	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	838	Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						TTGGTTCCAGGAACTTATAAA	0.438000													30	110					0	0	1	0	0
PRPF39	55015	broad.mit.edu	37	14	45564560	45564560	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:45564560G>A	ENST00000355765.6	+	2	288	c.118G>A	c.(118-120)Gaa>Aaa	p.E40K		NM_017922.3	NP_060392.3	Q86UA1	PRP39_HUMAN	pre-mRNA processing factor 39	40					mRNA processing|RNA splicing	nucleus	binding			breast(2)|endometrium(2)|kidney(4)|lung(3)|ovary(1)	12						GAACGTTACAGAAATGGAACA	0.433000													15	49					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37864656	37864656	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:37864656G>A	ENST00000406381.2	+	5	728	c.218G>A	c.(217-219)cGa>cAa	p.R73Q	ERBB2_ENST00000578199.1_Missense_Mutation_p.R73Q|ERBB2_ENST00000584450.1_Missense_Mutation_p.R103Q|ERBB2_ENST00000445658.2_Intron|ERBB2_ENST00000540042.1_Missense_Mutation_p.R73Q|ERBB2_ENST00000584601.1_Missense_Mutation_p.R73Q|ERBB2_ENST00000269571.5_Missense_Mutation_p.R103Q|ERBB2_ENST00000541774.1_Missense_Mutation_p.R88Q|ERBB2_ENST00000540147.1_Missense_Mutation_p.R73Q	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	103					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CGGATTGTGCGAGGCACCCAG	0.612000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			17	89					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166231402	166231402	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:166231402C>T	ENST00000375437.2	+	22	4470	c.4180C>T	c.(4180-4182)Caa>Taa	p.Q1394*	SCN2A_ENST00000375427.2_Nonsense_Mutation_p.Q1394*|SCN2A_ENST00000283256.6_Nonsense_Mutation_p.Q1394*|SCN2A_ENST00000357398.3_Nonsense_Mutation_p.Q1394*	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1394					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TGAGAGCAATCAAACTGCCAG	0.368000													15	61					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123845750	123845750	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:123845750G>A	ENST00000369005.1	+	4	4075	c.3735G>A	c.(3733-3735)caG>caA	p.Q1245Q	TACC2_ENST00000334433.3_Silent_p.Q1245Q|TACC2_ENST00000453444.2_Silent_p.Q1245Q|TACC2_ENST00000515603.1_Silent_p.Q1245Q|TACC2_ENST00000515273.1_Silent_p.Q1245Q|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000358010.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1245						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GTGCTGCCCAGAGAGGAGCAG	0.612000													10	144					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53998239	53998239	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:53998239C>T	ENST00000396328.1	-	10	1226	c.987G>A	c.(985-987)atG>atA	p.M329I	WDR72_ENST00000557913.1_Missense_Mutation_p.M326I|WDR72_ENST00000360509.5_Missense_Mutation_p.M329I|WDR72_ENST00000559418.1_Missense_Mutation_p.M339I	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	329										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TCCTTTCATTCATGTAGCCCA	0.388000													17	42					0	0	1	0	0
SLC25A6	293	broad.mit.edu	37	X	1508270	1508270	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:1508270G>A	ENST00000381401.5	-	2	1176	c.462C>T	c.(460-462)ttC>ttT	p.F154F	SLC25A6_ENST00000475167.1_5'UTR	NM_001636.3	NP_001627.2	P12236	ADT3_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	154					active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|upper_aerodigestive_tract(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	CCAGGCCTCGGAACTCGCGCT	0.647000													22	258					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7743780	7743780	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:7743780G>C	ENST00000338316.4	+	15	1960		c.e15-1		ADCY2_ENST00000537121.1_Splice_Site|RP11-711G10.1_ENST00000514105.2_RNA	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TTTCCCGGTAGAACGTCCGTC	0.473000													20	167					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169138148	169138148	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:169138148T>A	ENST00000393743.3	-	38	5366	c.5075A>T	c.(5074-5076)gAc>gTc	p.D1692V		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1692							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		GACAACGTTGTCGTCTTCATT	0.338000													11	47					0	0	1	0	0
SSH3	54961	broad.mit.edu	37	11	67077339	67077339	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:67077339G>A	ENST00000308127.4	+	12	1487	c.1309G>A	c.(1309-1311)Gag>Aag	p.E437K	SSH3_ENST00000376757.5_Missense_Mutation_p.E437K|SSH3_ENST00000308298.7_Intron	NM_017857.3	NP_060327.3	Q8TE77	SSH3_HUMAN	slingshot protein phosphatase 3	437	Tyrosine-protein phosphatase.				regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			ATGCAGCCTGGAGCAGGCCCT	0.672000													13	54					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87678051	87678051	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:87678051C>T	ENST00000284262.2	+	2	812	c.570C>T	c.(568-570)gcC>gcT	p.A190A		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	190					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		GCAGCCCGGCCGTGTCCCGCG	0.687000													12	47					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114299437	114299437	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:114299437A>G	ENST00000408937.3	+	13	1944	c.1570A>G	c.(1570-1572)Aaa>Gaa	p.K524E	FOXP2_ENST00000393494.2_Missense_Mutation_p.K499E|FOXP2_ENST00000403559.4_Missense_Mutation_p.K516E|FOXP2_ENST00000393498.2_Missense_Mutation_p.K478E|FOXP2_ENST00000393489.3_Missense_Mutation_p.K407E|FOXP2_ENST00000393491.3_Intron|FOXP2_ENST00000350908.4_Missense_Mutation_p.K499E|FOXP2_ENST00000393500.3_3'UTR	NM_001172766.2|NM_014491.3|NM_148898.3	NP_001166237.1|NP_055306.1|NP_683696.2	O15409	FOXP2_HUMAN	forkhead box P2	499					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						TGAATTTTATAAAAATGCAGA	0.264000													9	68					0	0	1	0	0
SYNJ2BP	55333	broad.mit.edu	37	14	70883644	70883644	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:70883644C>T	ENST00000256366.4	-	1	118	c.37G>A	c.(37-39)Gag>Aag	p.E13K	SYNJ2BP-COX16_ENST00000555276.1_RNA|SYNJ2BP_ENST00000554216.1_5'UTR	NM_018373.2	NP_060843.2			synaptojanin 2 binding protein											central_nervous_system(1)|kidney(2)|large_intestine(1)|upper_aerodigestive_tract(1)	5				all cancers(60;0.00367)|BRCA - Breast invasive adenocarcinoma(234;0.00716)|OV - Ovarian serous cystadenocarcinoma(108;0.0377)		AGATTGATCTCTTCCTCAGTG	0.502000													17	100					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37157850	37157850	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:37157850C>T	ENST00000274258.7	-	40	8160	c.4573G>A	c.(4573-4575)Gtt>Att	p.V1525I	C5orf42_ENST00000425232.2_Missense_Mutation_p.V2627I|C5orf42_ENST00000508244.1_Missense_Mutation_p.V2627I			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2627										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GACGATGGAACTGCTAGATGA	0.363000													10	71					0	0	1	0	0
HRCT1	646962	broad.mit.edu	37	9	35906475	35906475	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:35906475G>A	ENST00000354323.2	+	1	287	c.191G>A	c.(190-192)cGg>cAg	p.R64Q		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	64						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						TTCCGGCGGCGGGGCCACCTG	0.657000													10	33					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82877677	82877677	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:82877677G>A	ENST00000298281.4	+	5	2190	c.1738G>A	c.(1738-1740)Gaa>Aaa	p.E580K		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	580					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						GTCAGGCACTGAACCAAAGGA	0.388000													8	26					0	0	1	0	0
EML4	27436	broad.mit.edu	37	2	42513428	42513428	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:42513428G>C	ENST00000318522.5	+	10	1293	c.1031G>C	c.(1030-1032)aGa>aCa	p.R344T	EML4_ENST00000401738.3_Missense_Mutation_p.R355T|EML4_ENST00000402711.2_Missense_Mutation_p.R286T	NM_019063.3	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	344					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						CCCCACGTCAGAGTGTGGGAT	0.443000			T	ALK	NSCLC								25	90					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58549327	58549327	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:58549327C>T	ENST00000282326.1	+	3	370	c.123C>T	c.(121-123)ttC>ttT	p.F41F	ZSCAN1_ENST00000601162.1_Silent_p.F41F|ZSCAN1_ENST00000391700.1_Silent_p.F41F	NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	41	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GTCTGCGCTTCCGGCAGTTCC	0.726000													3	15					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71286745	71286745	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:71286745C>T	ENST00000283228.2	-	2	523	c.71G>A	c.(70-72)gGa>gAa	p.G24E		NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	24					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		ATCATTGTTTCCTGAAAAGCA	0.383000													8	176					0	0	1	0	0
EYA3	2140	broad.mit.edu	37	1	28354418	28354418	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:28354418C>T	ENST00000373871.3	-	7	621	c.381G>A	c.(379-381)atG>atA	p.M127I	EYA3_ENST00000540618.1_Intron|EYA3_ENST00000471498.1_5'UTR|EYA3_ENST00000373863.3_Intron|EYA3_ENST00000436342.2_Start_Codon_SNP_p.M1I|EYA3_ENST00000545175.1_Missense_Mutation_p.M74I|EYA3_ENST00000373864.1_Intron	NM_001282561.1|NM_001282562.1	NP_001269490.1|NP_001269491.1	Q99504	EYA3_HUMAN	eyes absent homolog 3 (Drosophila)	127					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		TTTCAGGTTTCATACCTGGCC	0.438000													26	89					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118969806	118969806	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:118969806T>C	ENST00000328252.3	+	3	1919	c.1550T>C	c.(1549-1551)tTt>tCt	p.F517S	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	517	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						AATATTTTCTTTGCAAAATCC	0.433000													12	41					0	0	1	0	0
CD96	10225	broad.mit.edu	37	3	111319679	111319679	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:111319679G>C	ENST00000352690.4	+	7	1245	c.1005G>C	c.(1003-1005)ttG>ttC	p.L335F	CD96_ENST00000283285.5_Missense_Mutation_p.L351F|CD96_ENST00000438817.2_Missense_Mutation_p.L335F	NM_005816.4	NP_005807.1	P40200	TACT_HUMAN	CD96 molecule	351	Ig-like C2-type.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(4)|liver(2)|lung(14)|skin(5)	35						CAGACAACTTGACCATTTGGT	0.368000									Opitz Trigonocephaly syndrome				11	65					0	0	1	0	0
POMGNT2	84892	broad.mit.edu	37	3	43122264	43122264	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:43122264C>T	ENST00000344697.2	-	2	1005	c.660G>A	c.(658-660)ctG>ctA	p.L220L	POMGNT2_ENST00000441964.1_Silent_p.L220L	NM_032806.5	NP_116195.2			protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)																		CCAGGGTCTTCAGCTGTGCCC	0.622000													38	68					0	0	1	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35944711	35944711	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:35944711C>T	ENST00000325722.3	-	4	1003	c.769G>A	c.(769-771)Ggt>Agt	p.G257S		NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	257						cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTAGCAAGACCCTCTGATATT	0.507000													12	89					0	0	1	0	0
RFT1	91869	broad.mit.edu	37	3	53133407	53133407	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:53133407C>T	ENST00000296292.3	-	11	1259	c.1198G>A	c.(1198-1200)Gag>Aag	p.E400K	RP11-894J14.5_ENST00000607203.1_Silent_p.R21R|RFT1_ENST00000394738.3_Missense_Mutation_p.E361K	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	400					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		CTGTCGACCTCCTCTTTGCTC	0.453000													14	54					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10908855	10908855	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:10908855C>T	ENST00000298232.7	-	22	1803	c.1436G>A	c.(1435-1437)tGg>tAg	p.W479*	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Nonsense_Mutation_p.W497*|TPTE_ENST00000342420.5_Nonsense_Mutation_p.W459*	NM_199259.2	NP_954868	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	497	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGTGTGCAACCAGAAGTAAAA	0.294000													4	35					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108381114	108381114	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:108381114G>C	ENST00000265843.4	-	6	5230	c.5120C>G	c.(5119-5121)tCa>tGa	p.S1707*	EXPH5_ENST00000428840.1_Nonsense_Mutation_p.S1631*|EXPH5_ENST00000443411.1_Nonsense_Mutation_p.S1519*|EXPH5_ENST00000525344.1_Nonsense_Mutation_p.S1700*	NM_015065.2	NP_055880	Q149M6	Q149M6_HUMAN	exophilin 5	1707					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TGGTGATTCTGAGACGTTTTT	0.438000													11	148					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46825920	46825920	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:46825920G>A	ENST00000283296.7	-	17	4008	c.3720C>T	c.(3718-3720)ttC>ttT	p.F1240F	GPR116_ENST00000265417.7_Silent_p.F1240F|GPR116_ENST00000545669.1_Silent_p.F669F|GPR116_ENST00000362015.4_Silent_p.F1240F|GPR116_ENST00000456426.2_Silent_p.F1098F	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1240					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			TGGTCCCTGGGAACACAGTGG	0.493000													7	46					0	0	1	0	0
NUP160	23279	broad.mit.edu	37	11	47834905	47834905	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:47834905C>G	ENST00000378460.2	-	14	1795	c.1749G>C	c.(1747-1749)gaG>gaC	p.E583D	NUP160_ENST00000530326.1_Missense_Mutation_p.E469D|NUP160_ENST00000528501.1_Missense_Mutation_p.E147D|NUP160_ENST00000528071.1_Missense_Mutation_p.E469D	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	583					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						TCAAAAGGTTCTCATAAGGCA	0.363000													6	49					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70049338	70049338	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:70049338T>G	ENST00000330891.5	-	10	1582	c.1356A>C	c.(1354-1356)aaA>aaC	p.K452N	BEST3_ENST00000553096.1_Missense_Mutation_p.K346N|BEST3_ENST00000331471.4_Intron|BEST3_ENST00000488961.1_Missense_Mutation_p.K239N	NM_001282613.1|NM_032735.2	NP_001269542.1|NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	452						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GGAAGCAGGATTTCTTCCAGG	0.592000													6	587					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21212805	21212805	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:21212805C>T	ENST00000574002.1	-	15	2061	c.1579G>A	c.(1579-1581)Gaa>Aaa	p.E527K	ZP2_ENST00000219593.4_Missense_Mutation_p.E527K|AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000574091.1_Missense_Mutation_p.E518K			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	527	ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		ACTCTCACTTCCATGTAAATT	0.468000													13	67					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74328486	74328486	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:74328486C>A	ENST00000409262.3	+	9	4166	c.4166C>A	c.(4165-4167)gCc>gAc	p.A1389D		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1389							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AGCACCTCGGCCTTGGCTGGG	0.652000													3	30					0.115264	0.115591	1	1	0
NKAIN4	128414	broad.mit.edu	37	20	61880196	61880196	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:61880196A>C	ENST00000370316.3	-	3	333	c.244T>G	c.(244-246)Ttc>Gtc	p.F82V	NKAIN4_ENST00000370313.1_Missense_Mutation_p.F20V|NKAIN4_ENST00000370307.2_Missense_Mutation_p.F20V	NM_152864.3	NP_690603.3	Q8IVV8	NKAI4_HUMAN	Na+/K+ transporting ATPase interacting 4	82						integral to membrane|plasma membrane				endometrium(2)|lung(1)|ovary(1)	4	all_cancers(38;2.72e-09)					TCCAGGTAGAAGCAGATGATG	0.637000													4	33					0	0	1	0	0
TTLL9	164395	broad.mit.edu	37	20	30522626	30522626	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:30522626C>T	ENST00000375938.4	+	12	1192	c.939C>T	c.(937-939)atC>atT	p.I313I	TTLL9_ENST00000310998.4_Silent_p.I278I|TTLL9_ENST00000375922.4_Silent_p.I255I|TTLL9_ENST00000375934.4_3'UTR|TTLL9_ENST00000535842.1_Silent_p.I313I|TTLL9_ENST00000375921.2_Intron			Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	313	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGAAGGTGATCATCAGTGACA	0.552000													19	140					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214819982	214819982	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:214819982C>G	ENST00000366955.3	+	13	7237	c.7069C>G	c.(7069-7071)Ctt>Gtt	p.L2357V		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2453	2 X 177 AA tandem repeats.|Interaction with NDE1 and NDEL1.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GCATGCAGCTCTTGAGGCAGA	0.433000													12	22					0	0	1	0	0
METTL17	64745	broad.mit.edu	37	14	21464929	21464929	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:21464929C>T	ENST00000382985.4	+	13	1347	c.1324C>T	c.(1324-1326)Cat>Tat	p.H442Y	METTL17_ENST00000556670.2_Intron|METTL17_ENST00000339374.6_Intron|RP11-84C10.4_ENST00000557335.1_RNA			Q9H7H0	MET17_HUMAN	methyltransferase like 17	0					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20						CCCACGCCAGCATCTGTTTCC	0.582000													15	59					0	0	1	0	0
MYLK2	85366	broad.mit.edu	37	20	30418869	30418869	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:30418869C>T	ENST00000375994.2	+	9	1622	c.1349C>T	c.(1348-1350)tCa>tTa	p.S450L	MYLK2_ENST00000468730.1_3'UTR|MYLK2_ENST00000375985.4_Missense_Mutation_p.S450L			Q9H1R3	MYLK2_HUMAN	myosin light chain kinase 2	450	Protein kinase.				cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GAGTTCCTGTCACCTGAGGTG	0.542000													7	54					0	0	1	0	0
ZNF616	90317	broad.mit.edu	37	19	52619263	52619263	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:52619263T>C	ENST00000600228.1	-	4	1415	c.1154A>G	c.(1153-1155)gAa>gGa	p.E385G	ZNF616_ENST00000330123.5_3'UTR	NM_178523.3	NP_848618.2	Q08AN1	ZN616_HUMAN	zinc finger protein 616	385					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		CTTGCCACATTCATTGCATTT	0.413000													13	227					0	0	1	0	0
FDPS	2224	broad.mit.edu	37	1	155288460	155288460	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:155288460C>T	ENST00000356657.6	+	7	851	c.689C>T	c.(688-690)tCc>tTc	p.S230F	RUSC1-AS1_ENST00000543656.1_RNA|FDPS_ENST00000368356.4_Missense_Mutation_p.S230F|RUSC1-AS1_ENST00000443642.1_RNA|RUSC1-AS1_ENST00000446880.1_RNA|FDPS_ENST00000447866.1_Missense_Mutation_p.S164F	NM_001135821.1	NP_001129293.1	P14324	FPPS_HUMAN	farnesyl diphosphate synthase	230					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	GCTTAGAGTTCCTATCAGACT	0.537000													6	43					0	0	1	0	0
DEFA5	1670	broad.mit.edu	37	8	6914080	6914080	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:6914080G>C	ENST00000330590.2	-	1	176	c.140C>G	c.(139-141)gCa>gGa	p.A47G		NM_021010.1	NP_066290.1	Q01523	DEF5_HUMAN	defensin, alpha 5, Paneth cell-specific	47					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				NS(1)|lung(4)|skin(1)|stomach(1)	7				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		TCCATTTCCTGCAAAGGAGAT	0.498000													6	93					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67315056	67315056	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:67315056C>T	ENST00000360461.5	+	4	3317	c.782C>T	c.(781-783)tCt>tTt	p.S261F	PLEKHG4_ENST00000379344.3_Missense_Mutation_p.S261F|PLEKHG4_ENST00000450733.1_Missense_Mutation_p.S180F|PLEKHG4_ENST00000427155.2_Missense_Mutation_p.S261F	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	261					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		GCTCCAAGTTCTTCCCTCTTC	0.473000													10	82					0	0	1	0	0
RNF19A	25897	broad.mit.edu	37	8	101270947	101270947	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:101270947G>C	ENST00000519449.1	-	11	2670	c.2354C>G	c.(2353-2355)tCc>tGc	p.S785C	RNF19A_ENST00000341084.2_Missense_Mutation_p.S785C	NM_001280539.1|NM_015435.3	NP_001267468.1|NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	785	Interaction with CASR.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			TTCTGAACAGGAAGCAGTTTG	0.383000													119	121					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120548019	120548019	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:120548019C>T	ENST00000256646.2	-	3	567	c.348G>A	c.(346-348)ctG>ctA	p.L116L	NOTCH2_ENST00000602566.1_Silent_p.L77L	NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	116	EGF-like 3.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGCCGCCATTCAGGCAGGGTC	0.532000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				12	88					0	0	1	0	0
CLK2	1196	broad.mit.edu	37	1	155235656	155235656	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:155235656C>T	ENST00000368361.4	-	8	1243	c.928G>A	c.(928-930)Gag>Aag	p.E310K	CLK2_ENST00000361168.5_Missense_Mutation_p.E309K|CLK2_ENST00000355560.4_Missense_Mutation_p.E308K|CLK2_ENST00000497188.1_5'UTR|CLK2_ENST00000536801.1_Missense_Mutation_p.E310K			P49760	CLK2_HUMAN	CDC-like kinase 2	310	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTTACCTTCTCTAGGTTGTAG	0.478000								Other conserved DNA damage response genes					7	101					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	64005028	64005028	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:64005028C>T	ENST00000443617.2	-	24	4617	c.4530G>A	c.(4528-4530)tcG>tcA	p.S1510S	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1510					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						ATTCACTCCTCGATTTGATCA	0.398000													4	16					0	0	1	0	0
LOXL4	84171	broad.mit.edu	37	10	100021874	100021874	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:100021874G>A	ENST00000260702.3	-	3	524	c.374C>T	c.(373-375)tCa>tTa	p.S125L		NM_032211.6	NP_115587.6	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4	125	SRCR 1.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(8)|ovary(4)|prostate(1)|skin(2)	26		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		TACGTCTTCTGAGTGACTGCA	0.597000													8	28					0	0	1	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64132620	64132620	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:64132620G>A	ENST00000295902.6	-	7	2131	c.1546C>T	c.(1546-1548)Cag>Tag	p.Q516*	PRICKLE2_ENST00000564377.1_Nonsense_Mutation_p.Q572*	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	516						cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CGACACTGCTGAGTGGACAAG	0.557000													16	79					0	0	1	0	0
HK1	3098	broad.mit.edu	37	10	71129043	71129043	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:71129043G>A	ENST00000448642.2	+	11	1136	c.747G>A	c.(745-747)atG>atA	p.M249I	HK1_ENST00000359426.6_Missense_Mutation_p.M214I|HK1_ENST00000404387.2_Missense_Mutation_p.M218I|HK1_ENST00000494253.1_3'UTR|HK1_ENST00000360289.2_Missense_Mutation_p.M202I|HK1_ENST00000298649.3_Missense_Mutation_p.M213I			P19367	HXK1_HUMAN	hexokinase 1	214	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						TGGGCACCATGATGACCTGTG	0.532000													16	66					0	0	1	0	0
ZIK1	284307	broad.mit.edu	37	19	58102555	58102555	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:58102555G>C	ENST00000597850.1	+	4	1591	c.1376G>C	c.(1375-1377)gGa>gCa	p.G459A	ZIK1_ENST00000536878.2_Missense_Mutation_p.G446A|ZIK1_ENST00000599456.1_Missense_Mutation_p.G404A|ZIK1_ENST00000307468.4_3'UTR	NM_001010879.2	NP_001010879.2	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein 1	459					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	34		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTTCACACTGGAGAAAGGCCT	0.453000													10	69					0	0	1	0	0
CLASP2	23122	broad.mit.edu	37	3	33552169	33552169	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:33552169G>A	ENST00000399362.4	-	37	4572	c.4219C>T	c.(4219-4221)Caa>Taa	p.Q1407*	CLASP2_ENST00000539981.1_3'UTR|CLASP2_ENST00000468888.2_Nonsense_Mutation_p.Q1408*|CLASP2_ENST00000480013.1_Nonsense_Mutation_p.Q1187*|CLASP2_ENST00000307312.7_Nonsense_Mutation_p.Q889*|CLASP2_ENST00000461133.3_Nonsense_Mutation_p.Q1167*|CLASP2_ENST00000359576.5_Nonsense_Mutation_p.Q1399*	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	1409										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						TCTGCAGTTTGAATGATAGGA	0.428000													14	19					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130884302	130884302	+	Silent	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:130884302A>C	ENST00000261655.4	-	18	3217	c.3054T>G	c.(3052-3054)ccT>ccG	p.P1018P		NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	1018	SH3 3.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CTACGTCATCAGGCACTTCTT	0.458000													25	50					0	0	1	0	0
EYA2	2139	broad.mit.edu	37	20	45618709	45618709	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:45618709G>A	ENST00000327619.5	+	2	434	c.60G>A	c.(58-60)ctG>ctA	p.L20L	EYA2_ENST00000357410.3_Silent_p.L20L|EYA2_ENST00000497428.1_3'UTR|EYA2_ENST00000317304.6_Silent_p.L20L	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	20					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				TGGATAAACTGAAGTTTAACC	0.453000													7	58					0	0	1	0	0
TBC1D23	55773	broad.mit.edu	37	3	99979886	99979886	+	Silent	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:99979886G>T	ENST00000394144.4	+	1	31	c.24G>T	c.(22-24)ccG>ccT	p.P8P	TBC1D23_ENST00000344949.5_Silent_p.P8P	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	8						intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						AAGATGTGCCGCCGCTGCCAA	0.567000													11	62					1.61879e-10	1.68669e-10	1	1	0
HYDIN	54768	broad.mit.edu	37	16	71012936	71012936	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:71012936T>G	ENST00000393567.2	-	30	4669	c.4519A>C	c.(4519-4521)Aag>Cag	p.K1507Q		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1507										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				ATTTCATACTTTTCATTTGCT	0.423000													3	41					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5427339	5427339	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:5427339C>A	ENST00000399537.4	-	5	2464	c.2116G>T	c.(2116-2118)Gac>Tac	p.D706Y	TNRC18_ENST00000430969.1_Missense_Mutation_p.D706Y			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	706							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CGCTCCTGGTCTACCAGCCCA	0.647000													11	63					0.00010058	0.000102683	1	1	0
AMDHD1	144193	broad.mit.edu	37	12	96356175	96356175	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:96356175G>A	ENST00000266736.2	+	6	962	c.856G>A	c.(856-858)Gaa>Aaa	p.E286K		NM_152435.2	NP_689648.2	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	286					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|skin(1)	22						CCACCTGGAAGAAGTGAGTGA	0.527000													7	42					0	0	1	0	0
TAX1BP1	8887	broad.mit.edu	37	7	27834003	27834003	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:27834003C>T	ENST00000396319.2	+	11	1560	c.1472C>T	c.(1471-1473)tCa>tTa	p.S491L	TAX1BP1_ENST00000409980.1_Missense_Mutation_p.S491L|TAX1BP1_ENST00000265393.6_Missense_Mutation_p.S491L|TAX1BP1_ENST00000543117.1_Missense_Mutation_p.S491L|TAX1BP1_ENST00000433216.2_Missense_Mutation_p.S334L	NM_006024.6	NP_006015.4	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I) binding protein 1	491					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(8)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31			GBM - Glioblastoma multiforme(3;0.0823)			AATGATGCTTCAGTAAACACA	0.368000													12	77					0	0	1	0	0
ZBED4	9889	broad.mit.edu	37	22	50280475	50280475	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:50280475G>A	ENST00000216268.5	+	2	3642	c.3165G>A	c.(3163-3165)tcG>tcA	p.S1055S		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4							cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		GCTCCCCGTCGAAAGACTCTG	0.532000													9	30					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77661698	77661698	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:77661698G>A	ENST00000296043.6	+	5	3325	c.2372G>A	c.(2371-2373)cGa>cAa	p.R791Q		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	791					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			TTCGAGCAGCGAGAGCAAGGG	0.617000													3	20					0	0	1	0	0
CNKSR1	10256	broad.mit.edu	37	1	26515797	26515797	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:26515797G>A	ENST00000531191.1	+	20	2133	c.1126G>A	c.(1126-1128)Gaa>Aaa	p.E376K	CNKSR1_ENST00000361530.6_Missense_Mutation_p.E634K|CNKSR1_ENST00000374253.5_Missense_Mutation_p.E641K			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	641	Pro-rich.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGGTCCTAGAAGAAGTGCT	0.617000													6	38					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2706608	2706608	+	Silent	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:2706608A>C	ENST00000480911.1	+	21	2824	c.2799A>C	c.(2797-2799)ctA>ctC	p.L933L	CACNA1C_ENST00000399591.1_Silent_p.L933L|CACNA1C_ENST00000399655.1_Intron|CACNA1C_ENST00000399637.1_Silent_p.L933L|CACNA1C_ENST00000399595.1_Intron|CACNA1C_ENST00000344100.3_Intron|CACNA1C_ENST00000399629.1_Silent_p.L933L|CACNA1C_ENST00000399606.1_Silent_p.L953L|CACNA1C_ENST00000399601.1_Silent_p.L933L|CACNA1C_ENST00000399621.1_Intron|CACNA1C_ENST00000399634.1_Intron|CACNA1C_ENST00000402845.3_Intron|CACNA1C_ENST00000399638.1_Intron|CACNA1C_ENST00000399603.1_Intron|CACNA1C_ENST00000399617.1_Intron|CACNA1C_ENST00000347598.4_Silent_p.L953L|CACNA1C_ENST00000399644.1_Silent_p.L933L|CACNA1C_ENST00000399649.1_Intron|CACNA1C_ENST00000399597.1_Intron|CACNA1C_ENST00000327702.7_Silent_p.L933L|CACNA1C_ENST00000335762.5_Intron|CACNA1C_ENST00000406454.3_Intron|CACNA1C_ENST00000399641.1_Silent_p.L933L			Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	953					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TTCAGATCCTAGGCAATGCAG	0.433000													15	38					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	145160397	145160397	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:145160397C>T	ENST00000367545.3	+	71	10154	c.10154C>T	c.(10153-10155)tCc>tTc	p.S3385F	UTRN_ENST00000367526.4_Missense_Mutation_p.S940F	NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	3385					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CCAGATGCCTCCGGCCCACAG	0.527000													4	40					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59270301	59270301	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:59270301G>A	ENST00000320743.3	-	16	2907	c.2621C>T	c.(2620-2622)tCa>tTa	p.S874L	LRIG3_ENST00000379141.4_Missense_Mutation_p.S814L	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	874						integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			TCCACTTTCTGAAGACACGTA	0.433000			T	ROS1	NSCLC								9	55					0	0	1	0	0
SIGMAR1	10280	broad.mit.edu	37	9	34637058	34637058	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:34637058G>A	ENST00000378892.1	-	2	541	c.114C>T	c.(112-114)acC>acT	p.T38T	SIGMAR1_ENST00000477726.1_Intron|SIGMAR1_ENST00000461426.1_Intron|SIGMAR1_ENST00000277010.4_Silent_p.T127T			Q99720	SGMR1_HUMAN	sigma non-opioid intracellular receptor 1	127					ergosterol biosynthetic process|lipid transport	cell junction|endoplasmic reticulum membrane|growth cone|integral to plasma membrane|lipid particle|nuclear inner membrane|nuclear outer membrane	C-8 sterol isomerase activity|drug binding			large_intestine(1)|lung(1)	2					Dextromethorphan(DB00514)	CAGAGATGATGGTATCCGAGA	0.547000													6	19					0	0	1	0	0
STAU1	6780	broad.mit.edu	37	20	47733705	47733705	+	Silent	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:47733705G>T	ENST00000371828.3	-	12	1852	c.1365C>A	c.(1363-1365)atC>atA	p.I455I	STAU1_ENST00000347458.5_Silent_p.I449I|STAU1_ENST00000371856.2_Silent_p.I530I|STAU1_ENST00000360426.4_Silent_p.I449I|STAU1_ENST00000371792.1_Silent_p.I447I|STAU1_ENST00000371802.1_Silent_p.I455I|STAU1_ENST00000340954.7_Silent_p.I449I	NM_001037328.1|NM_004602.2	NP_001032405.1|NP_004593.2	O95793	STAU1_HUMAN	staufen double-stranded RNA binding protein 1	530						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding	p.I530I(1)		breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	23			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			TACCATGGCTGATCAGAGGTG	0.473000													9	60					1.12685e-05	1.15625e-05	1	1	0
YAE1D1	57002	broad.mit.edu	37	7	39612184	39612184	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:39612184G>A	ENST00000223273.2	+	3	603	c.560G>A	c.(559-561)aGa>aAa	p.R187K	YAE1D1_ENST00000432096.2_Intron	NM_020192.3	NP_064577.1	Q9NRH1	CG036_HUMAN	Yae1 domain containing 1	187																	GAATGTTGTAGAACACAGGAG	0.393000													7	64					0	0	1	0	0
TGIF2LY	90655	broad.mit.edu	37	Y	3447348	3447348	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrY:3447348G>A	ENST00000559055.2	+	1	193	c.63G>A	c.(61-63)gcG>gcA	p.A21A	TGIF2LY_ENST00000321217.4_Silent_p.A21A			Q8IUE0	TF2LY_HUMAN	TGFB-induced factor homeobox 2-like, Y-linked	21						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|upper_aerodigestive_tract(1)	2						ACAGCCCGGCGAAGACCCAAA	0.522000													10	23					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86479856	86479856	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:86479856T>A	ENST00000439827.1	+	4	1666	c.1495T>A	c.(1495-1497)Tca>Aca	p.S499T	GRM3_ENST00000546348.1_Silent_p.S446S|GRM3_ENST00000361669.2_Silent_p.S854S|GRM3_ENST00000536043.1_Silent_p.S726S|GRM3_ENST00000394720.2_Missense_Mutation_p.S497T			Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	0					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CCACATACTCTCAGTGTAAGT	0.478000													5	52					0	0	1	0	0
ZIK1	284307	broad.mit.edu	37	19	58102135	58102135	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:58102135G>A	ENST00000597850.1	+	4	1171	c.956G>A	c.(955-957)gGa>gAa	p.G319E	ZIK1_ENST00000536878.2_Missense_Mutation_p.G306E|ZIK1_ENST00000599456.1_Missense_Mutation_p.G264E|ZIK1_ENST00000307468.4_3'UTR	NM_001010879.2	NP_001010879.2	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein 1	319					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	34		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ATACACACTGGAGCAAGGCCT	0.453000													13	64					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155237115	155237115	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:155237115A>G	ENST00000357232.4	-	15	3679	c.3680T>C	c.(3679-3681)tTg>tCg	p.L1227S		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTCATAATCCAAAGGACAGGT	0.378000													9	39					0	0	1	0	0
EXTL2	2135	broad.mit.edu	37	1	101339878	101339878	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:101339878C>G	ENST00000370114.3	-	5	2049	c.613G>C	c.(613-615)Ggt>Cgt	p.G205R	EXTL2_ENST00000535414.1_Missense_Mutation_p.G192R|EXTL2_ENST00000370113.3_Missense_Mutation_p.G205R	NM_001033025.2|NM_001261440.1	NP_001028197.1|NP_001248369.1	Q9UBQ6	EXTL2_HUMAN	exostosin-like glycosyltransferase 2	205					N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	14		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		TACTGGTCACCATTTCCAGAC	0.408000													6	98					0	0	1	0	0
CHN1	1123	broad.mit.edu	37	2	175664883	175664883	+	Silent	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:175664883C>A	ENST00000409900.3	-	13	1654	c.1341G>T	c.(1339-1341)gtG>gtT	p.V447V	CHN1_ENST00000488080.1_5'UTR|CHN1_ENST00000409156.3_Silent_p.V421V|CHN1_ENST00000295497.7_Silent_p.V322V|CHN1_ENST00000409597.1_Silent_p.V263V	NM_001822.5	NP_001813.1	P15882	CHIN_HUMAN	chimerin 1	447	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.226)			GCAGCTCCACCACCAGTCTCT	0.368000			T	TAF15	extraskeletal myxoid chondrosarcoma								6	19					0.217242	0.217549	1	1	0
KCNAB1	7881	broad.mit.edu	37	3	156192557	156192557	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:156192557G>A	ENST00000302490.8	+	8	1423	c.552G>A	c.(550-552)gaG>gaA	p.E184E	KCNAB1_ENST00000490337.1_Silent_p.E202E|KCNAB1_ENST00000497291.1_3'UTR|KCNAB1_ENST00000389634.5_Intron|KCNAB1_ENST00000471742.1_Silent_p.E191E|KCNAB1_ENST00000389636.5_Intron	NM_172159.3	NP_751891.1	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	202						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TGCAGCTCGAGTATGTGGATG	0.428000													14	59					0	0	1	0	0
ECD	11319	broad.mit.edu	37	10	74908106	74908106	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:74908106C>T	ENST00000372979.4	-	8	1175	c.969G>A	c.(967-969)aaG>aaA	p.K323K	ECD_ENST00000430082.2_Silent_p.K323K|ECD_ENST00000454759.2_Silent_p.K280K	NM_007265.2	NP_009196.1	O95905	SGT1_HUMAN	ecdysoneless homolog (Drosophila)	323					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(51;0.0119)					CAAGGGATTTCTTGCAGTCAG	0.373000													4	57					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47296184	47296184	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:47296184G>A	ENST00000342922.4	+	3	490	c.133G>A	c.(133-135)Gag>Aag	p.E45K	MADD_ENST00000395344.3_Missense_Mutation_p.E45K|MADD_ENST00000402799.1_Missense_Mutation_p.E45K|MADD_ENST00000406482.1_Missense_Mutation_p.E45K|MADD_ENST00000395336.3_Missense_Mutation_p.E45K|MADD_ENST00000402192.2_Missense_Mutation_p.E45K|MADD_ENST00000407859.3_Missense_Mutation_p.E45K|MADD_ENST00000349238.3_Missense_Mutation_p.E45K|MADD_ENST00000311027.5_Missense_Mutation_p.E45K	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	45	UDENN.				activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		GGATCACACTGAGTTTCCCCT	0.572000													13	168					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92952988	92952988	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:92952988C>G	ENST00000544910.1	+	22	2051	c.1831C>G	c.(1831-1833)Caa>Gaa	p.Q611E	CCDC132_ENST00000305866.5_Missense_Mutation_p.Q641E|CCDC132_ENST00000541136.1_Missense_Mutation_p.Q452E|CCDC132_ENST00000535481.1_Missense_Mutation_p.Q361E	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	641										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTCATGTCTCAACTATTTGA	0.279000													13	96					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22806823	22806823	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:22806823G>A	ENST00000361524.3	-	4	1207	c.1059C>T	c.(1057-1059)tcC>tcT	p.S353S	ZNF521_ENST00000538137.2_Silent_p.S353S|ZNF521_ENST00000584787.1_Silent_p.S133S	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	353					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TACTGGACACGGAGGTATAGC	0.572000			T	PAX5	ALL								12	43					0	0	1	0	0
LCTL	197021	broad.mit.edu	37	15	66840870	66840870	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:66840870G>A	ENST00000341509.5	-	13	1793	c.1662C>T	c.(1660-1662)atC>atT	p.I554I	ZWILCH_ENST00000307897.5_3'UTR|ZWILCH_ENST00000446801.2_3'UTR|LCTL_ENST00000537670.1_Silent_p.I381I	NM_207338.2	NP_997221.2	Q6UWM7	LCTL_HUMAN	lactase-like	554					carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GAACAGCAGTGATGAGGACAC	0.473000													14	75					0	0	1	0	0
C10orf91	170393	broad.mit.edu	37	10	134261312	134261312	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:134261312G>A	ENST00000392630.3	+	3	246	c.185G>A	c.(184-186)aGa>aAa	p.R62K	C10orf91_ENST00000321248.2_Missense_Mutation_p.R62K|C10orf91_ENST00000490765.1_3'UTR	NM_173541.2	NP_775812.1	Q5T1B1	CJ091_HUMAN	chromosome 10 open reading frame 91	62										endometrium(1)|kidney(1)|lung(1)|ovary(2)	5		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;6.95e-05)|Epithelial(32;0.000142)|all cancers(32;0.000162)		CCTCAGACAAGAAGCACGTCG	0.602000													12	81					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70993710	70993710	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:70993710C>G	ENST00000393567.2	-	39	6132	c.5982G>C	c.(5980-5982)caG>caC	p.Q1994H		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1994										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TGTCAATGCTCTGAAGCTTGT	0.473000													3	31					0	0	1	0	0
PAICS	10606	broad.mit.edu	37	4	57307853	57307853	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:57307853A>G	ENST00000264221.2	+	3	272	c.41A>G	c.(40-42)tAt>tGt	p.Y14C	PAICS_ENST00000514888.1_5'UTR|PAICS_ENST00000399688.3_Missense_Mutation_p.Y14C|PAICS_ENST00000512576.1_Missense_Mutation_p.Y14C	NM_006452.3	NP_006443.1	P22234	PUR6_HUMAN	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	14	SAICAR synthetase.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|identical protein binding|phosphoribosylaminoimidazole carboxylase activity|phosphoribosylaminoimidazolesuccinocarboxamide synthase activity			endometrium(1)|kidney(2)|large_intestine(1)|urinary_tract(1)	5	Glioma(25;0.08)|all_neural(26;0.101)				L-Aspartic Acid(DB00128)	AAAAAATTATATGAGGGTAAA	0.363000													4	3					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35823514	35823514	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:35823514C>T	ENST00000085219.5	+	3	165	c.99C>T	c.(97-99)taC>taT	p.Y33Y	CD22_ENST00000594250.1_Silent_p.Y33Y|CD22_ENST00000536635.2_Silent_p.Y33Y|CD22_ENST00000341773.6_Silent_p.Y33Y|CD22_ENST00000270311.6_5'UTR|CD22_ENST00000595419.1_3'UTR|CD22_ENST00000419549.2_5'UTR|CD22_ENST00000544992.2_Silent_p.Y33Y	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	33	Ig-like V-type.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AAACCCTCTACGCCTGGGAGG	0.502000													9	46					0	0	1	0	0
EIF2S3	1968	broad.mit.edu	37	X	24091329	24091329	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:24091329C>T	ENST00000253039.4	+	11	1557	c.1304C>T	c.(1303-1305)aCa>aTa	p.T435I	EIF2S3_ENST00000460032.1_3'UTR	NM_001415.3	NP_001406.1	P41091	IF2G_HUMAN	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	435						cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(1)	12						CCAGTGTGCACAGAGGTAGGA	0.433000													17	35					0	0	1	0	0
RPL14	9045	broad.mit.edu	37	3	40500162	40500162	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:40500162G>A	ENST00000396203.2	+	3	267	c.135G>A	c.(133-135)gtG>gtA	p.V45V	RPL14_ENST00000338970.6_Silent_p.V45V|RPL14_ENST00000416518.1_Silent_p.V45V|RPL14_ENST00000461368.1_3'UTR	NM_001034996.2	NP_001030168.1	P50914	RL14_HUMAN	ribosomal protein L14	45					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome								KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GCACTCAAGTGAGGAGACAGG	0.463000													6	42					0	0	1	0	0
KDM1A	23028	broad.mit.edu	37	1	23397805	23397805	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:23397805G>A	ENST00000400181.4	+	13	1605	c.1501G>A	c.(1501-1503)Gag>Aag	p.E501K	KDM1A_ENST00000356634.3_Missense_Mutation_p.E477K|KDM1A_ENST00000542151.1_Missense_Mutation_p.E501K|RP1-184J9.2_ENST00000427154.1_RNA	NM_001009999.2	NP_001009999.1	O60341	KDM1A_HUMAN	lysine (K)-specific demethylase 1A	477	Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(2)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TATTACTGCCGAGTTCTTAGT	0.388000													14	73					0	0	1	0	0
EOGT	285203	broad.mit.edu	37	3	69053539	69053539	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:69053539G>A	ENST00000383701.3	-	8	1352	c.610C>T	c.(610-612)Ctg>Ttg	p.L204L	EOGT_ENST00000295571.5_Silent_p.L204L|EOGT_ENST00000540955.1_5'UTR|EOGT_ENST00000540764.1_Silent_p.L103L	NM_001278689.1	NP_001265618.1			EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase									p.L204L(1)									CATGACTGCAGAGGGCTTTTG	0.403000													12	58					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120935548	120935548	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:120935548A>G	ENST00000310396.5	+	23	3390	c.2923A>G	c.(2923-2925)Aga>Gga	p.R975G		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		GAAAAGATCAAGAAATCATAT	0.318000													5	20					0	0	1	0	0
MELK	9833	broad.mit.edu	37	9	36671008	36671008	+	Missense_Mutation	SNP	G	G	A	rs2068826		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:36671008G>A	ENST00000543751.1	+	15	1568	c.1423G>A	c.(1423-1425)Gaa>Aaa	p.E475K	MELK_ENST00000536860.1_Missense_Mutation_p.E459K|MELK_ENST00000536329.1_Missense_Mutation_p.E436K|MELK_ENST00000545008.1_Missense_Mutation_p.E436K|MELK_ENST00000536987.1_Missense_Mutation_p.E376K|MELK_ENST00000541717.1_Missense_Mutation_p.E466K|MELK_ENST00000538311.1_Missense_Mutation_p.E313K|MELK_ENST00000298048.2_Missense_Mutation_p.E507K	NM_001256689.1	NP_001243618.1	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	507						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			CCGCTCAGTGGAATTGGATCT	0.488000													20	48					0	0	1	0	0
OR52E4	390081	broad.mit.edu	37	11	5906339	5906339	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:5906339A>G	ENST00000316987.2	+	1	839	c.817A>G	c.(817-819)Atc>Gtc	p.I273V		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	273					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCCCACTATATCCATATTCT	0.423000													16	105					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48808843	48808843	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:48808843A>G	ENST00000309835.3	+	1	1081	c.1071A>G	c.(1069-1071)aaA>aaG	p.K357K	STON1-GTF2A1L_ENST00000402114.2_Silent_p.K357K|STON1-GTF2A1L_ENST00000394751.3_Silent_p.K357K|STON1-GTF2A1L_ENST00000405008.1_Silent_p.K357K|STON1-GTF2A1L_ENST00000309827.2_Silent_p.K357K|STON1-GTF2A1L_ENST00000394754.1_Silent_p.K357K|STON1_ENST00000406226.1_Silent_p.K357K|STON1_ENST00000404752.1_Silent_p.K357K					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ACACAGAAAAAAGGAAATACC	0.408000													21	54					0	0	1	0	0
APOBEC3D	140564	broad.mit.edu	37	22	39421090	39421090	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:39421090G>A	ENST00000216099.8	+	3	633	c.226G>A	c.(226-228)Gag>Aag	p.E76K	APOBEC3D_ENST00000381568.4_Missense_Mutation_p.E76K|APOBEC3D_ENST00000427494.2_Intron	NM_152426.3	NP_689639.2	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D						negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)	11	Melanoma(58;0.04)					TTTCCGGTTTGAGAACCACGC	0.602000													10	27					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25965563	25965563	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:25965563G>A	ENST00000435504.4	-	13	3936	c.3643C>T	c.(3643-3645)Cac>Tac	p.H1215Y	ASXL2_ENST00000336112.4_Missense_Mutation_p.H1187Y|ASXL2_ENST00000272341.4_Missense_Mutation_p.H698Y|ASXL2_ENST00000404843.1_Missense_Mutation_p.H698Y			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	1215					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCCTGCTGTGAGGTCCTGAA	0.463000													9	38					0	0	1	0	0
HOXB6	3216	broad.mit.edu	37	17	46675164	46675164	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:46675164C>T	ENST00000484302.2	-	2	971	c.349G>A	c.(349-351)Gag>Aag	p.E117K	HOXB-AS3_ENST00000429755.4_RNA|HOXB-AS3_ENST00000480872.1_RNA|HOXB3_ENST00000552000.2_Intron|HOXB-AS3_ENST00000466037.2_RNA|HOXB6_ENST00000225648.3_Missense_Mutation_p.E117K|HOXB-AS3_ENST00000476204.1_RNA|HOXB-AS3_ENST00000487849.3_RNA|HOXB-AS3_ENST00000492897.3_RNA|HOXB-AS3_ENST00000477144.1_RNA|HOXB-AS3_ENST00000474040.1_RNA|HOXB-AS3_ENST00000467155.2_RNA|HOXB-AS3_ENST00000460041.1_RNA|HOXB-AS3_ENST00000481995.1_RNA|HOXB-AS3_ENST00000465846.2_RNA|HOXB-AS3_ENST00000474324.1_RNA			P17509	HXB6_HUMAN	homeobox B6	117					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(1)|lung(4)	7						TCTTCTGTCTCGCCGAACACG	0.657000													4	9					0	0	1	0	0
FGFR1	2260	broad.mit.edu	37	8	38279342	38279342	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:38279342G>A	ENST00000447712.2	-	8	1995	c.1054C>T	c.(1054-1056)Cac>Tac	p.H352Y	FGFR1_ENST00000341462.5_Intron|FGFR1_ENST00000335922.5_Missense_Mutation_p.H344Y|FGFR1_ENST00000397113.2_Missense_Mutation_p.H350Y|FGFR1_ENST00000397103.1_Intron|FGFR1_ENST00000532791.1_Missense_Mutation_p.H352Y|FGFR1_ENST00000397108.4_Missense_Mutation_p.H350Y|FGFR1_ENST00000425967.3_Missense_Mutation_p.H383Y|FGFR1_ENST00000326324.6_Missense_Mutation_p.H261Y|FGFR1_ENST00000397091.5_Missense_Mutation_p.H350Y|FGFR1_ENST00000356207.5_Missense_Mutation_p.H263Y	NM_001174063.1|NM_015850.3|NM_023110.2	NP_001167534.1|NP_056934.2|NP_075598.2	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1	352	Ig-like C2-type 3.				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity		FGFR1/ZNF703(2)	breast(2)|central_nervous_system(7)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(18)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	50	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	CATGCAGAGTGATGGGAGAGT	0.547000		1	T	"""BCR, FOP, ZNF198, CEP1"""	"""MPD, NHL"""		"""Pfeiffer syndrome, Kallman syndrome"""						8	51					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78381463	78381463	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:78381463C>T	ENST00000278550.7	-	32	6389	c.5927G>A	c.(5926-5928)aGa>aAa	p.R1976K		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		ATAGATGTTTCTGTAGTAGCC	0.552000													5	27					0	0	1	0	0
STYK1	55359	broad.mit.edu	37	12	10774501	10774501	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:10774501C>T	ENST00000075503.3	-	10	1558	c.1038G>A	c.(1036-1038)aaG>aaA	p.K346K		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	346	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						TACTGGGTCTCTTCATGATTT	0.433000										HNSCC(73;0.22)			11	67					0	0	1	0	0
ODF2	4957	broad.mit.edu	37	9	131256926	131256926	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:131256926C>T	ENST00000434106.3	+	17	2253	c.1890C>T	c.(1888-1890)atC>atT	p.I630I	ODF2_ENST00000351030.3_Silent_p.I625I|ODF2_ENST00000448249.3_Silent_p.I549I|ODF2_ENST00000372814.3_Silent_p.I674I|ODF2_ENST00000444119.2_Silent_p.I606I|ODF2_ENST00000546203.1_Silent_p.I611I|ODF2_ENST00000372807.5_Silent_p.I625I|ODF2_ENST00000372791.3_Silent_p.I611I|ODF2_ENST00000393527.3_Silent_p.I606I|ODF2_ENST00000393533.2_Silent_p.I630I|ODF2_ENST00000604420.1_Silent_p.I630I	NM_153433.1	NP_702911.1	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2						cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			autonomic_ganglia(1)|breast(7)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	37						TCACAGCCATCATATCAGACC	0.602000													5	38					0	0	1	0	0
MDM1	56890	broad.mit.edu	37	12	68725002	68725002	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:68725002C>T	ENST00000303145.7	-	2	105		c.e2-1		MDM1_ENST00000540418.1_Splice_Site|MDM1_ENST00000411698.2_Splice_Site|MDM1_ENST00000545724.1_Splice_Site|MDM1_ENST00000393543.3_Splice_Site|MDM1_ENST00000430606.2_Splice_Site	NM_017440.4	NP_059136.2	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)							nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		CACTCAGCCCCTGTAATGCAA	0.413000													37	139					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2942416	2942416	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:2942416G>C	ENST00000397461.1	+	10	1372	c.988G>C	c.(988-990)Gaa>Caa	p.E330Q	CNTN4_ENST00000427331.1_Missense_Mutation_p.E330Q|CNTN4_ENST00000418658.1_Missense_Mutation_p.E330Q|CNTN4_ENST00000358480.3_Missense_Mutation_p.E111Q|CNTN4_ENST00000397459.2_Missense_Mutation_p.E2Q|CNTN4_ENST00000448906.2_Missense_Mutation_p.E2Q|CNTN4_ENST00000475817.1_3'UTR	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	330	Ig-like C2-type 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CGTGGCCATGGAAGAAAATGT	0.383000													9	79					0	0	1	0	0
MAPRE2	10982	broad.mit.edu	37	18	32706935	32706935	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:32706935G>C	ENST00000436190.2	+	6	872	c.598G>C	c.(598-600)Gct>Cct	p.A200P	MAPRE2_ENST00000300249.5_Missense_Mutation_p.A212P|MAPRE2_ENST00000588910.1_Missense_Mutation_p.A212P|MAPRE2_ENST00000589699.1_Missense_Mutation_p.A169P|MAPRE2_ENST00000538170.2_Missense_Mutation_p.A159P|MAPRE2_ENST00000413393.1_Missense_Mutation_p.A169P	NM_001143827.2	NP_001137299.1	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family, member 2	212	DCTN1-binding.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	9						AAGTCCAGCAGCTAAACCAGG	0.393000													26	63					0	0	1	0	0
CROT	54677	broad.mit.edu	37	7	87027883	87027883	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:87027883G>C	ENST00000331536.3	+	18	1947	c.1762G>C	c.(1762-1764)Gat>Cat	p.D588H	CROT_ENST00000419147.2_Missense_Mutation_p.D616H	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	588					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TCCCGAGACTGATGCGGAAAA	0.393000													7	69					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3753101	3753101	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:3753101C>G	ENST00000378230.3	-	10	1599	c.1275G>C	c.(1273-1275)ttG>ttC	p.L425F	CEP104_ENST00000460038.1_Intron	NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	425						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						TGGCTTCTCTCAAGGCCTTCT	0.512000													7	74					0	0	1	0	0
KIF22	3835	broad.mit.edu	37	16	29810953	29810953	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:29810953C>T	ENST00000561482.1	+	7	1428	c.791C>T	c.(790-792)tCt>tTt	p.S264F	KIF22_ENST00000400750.2_5'UTR|KIF22_ENST00000160827.4_Missense_Mutation_p.S332F|KIF22_ENST00000400751.5_Missense_Mutation_p.S264F|KIF22_ENST00000569382.2_Missense_Mutation_p.S264F|KIF22_ENST00000563263.1_3'UTR	NM_001256270.1	NP_001243199.1	Q14807	KIF22_HUMAN	kinesin family member 22	332	Kinesin-motor.				blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding			endometrium(1)|large_intestine(1)|lung(11)|skin(1)	14						CCTCAGGACTCTCTGGGTGGC	0.577000													9	57					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91788748	91788748	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:91788748C>T	ENST00000370425.3	-	22	2534	c.2436G>A	c.(2434-2436)ttG>ttA	p.L812L	HFM1_ENST00000370424.3_Silent_p.L491L|HFM1_ENST00000294696.5_Silent_p.L44L|HFM1_ENST00000462405.1_5'UTR	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	812	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AGCCAGCTATCAATGTAACCT	0.303000													15	137					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175096133	175096133	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:175096133A>C	ENST00000239462.4	+	13	3070	c.2957A>C	c.(2956-2958)cAg>cCg	p.Q986P		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	986	Fibronectin type-III 9.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCTGTAACGCAGTCTGGTGGC	0.488000													12	56					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16980756	16980756	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:16980756G>A	ENST00000379803.1	+	14	2402	c.2388G>A	c.(2386-2388)ctG>ctA	p.L796L	SIN3B_ENST00000248054.5_Silent_p.L764L|SIN3B_ENST00000595541.1_Silent_p.L354L	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	796					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						CCAGGCTGCTGAAGATCTACC	0.602000													7	28					0	0	1	0	0
LPAR6	10161	broad.mit.edu	37	13	48985612	48985612	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:48985612G>A	ENST00000378434.4	-	7	2572	c.948C>T	c.(946-948)ttC>ttT	p.F316F	RB1_ENST00000267163.4_Intron|LPAR6_ENST00000345941.2_Silent_p.F316F	NM_005767.5	NP_005758.2	P43657	LPAR6_HUMAN	lysophosphatidic acid receptor 6	316						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.0?(15)|p.?(4)		NS(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	14						GAACTTCAGAGAATCTGAAGT	0.338000													15	60					0	0	1	0	0
C9orf50	375759	broad.mit.edu	37	9	132382097	132382097	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:132382097G>A	ENST00000372478.4	-	2	722	c.521C>T	c.(520-522)cCg>cTg	p.P174L	NTMT1_ENST00000372486.1_Intron	NM_199350.3	NP_955382.3	Q5SZB4	CI050_HUMAN	chromosome 9 open reading frame 50	174										central_nervous_system(1)|endometrium(4)|large_intestine(2)|ovary(1)|skin(1)|urinary_tract(1)	10		Ovarian(14;0.00556)				TTGATGTTGCGGTGCTGGGGA	0.592000													9	24					0	0	1	0	0
NET1	10276	broad.mit.edu	37	10	5497048	5497048	+	Silent	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:5497048G>T	ENST00000355029.4	+	10	1306	c.1164G>T	c.(1162-1164)ctG>ctT	p.L388L	NET1_ENST00000542715.1_Silent_p.L207L|NET1_ENST00000380359.3_Silent_p.L334L|NET1_ENST00000484741.1_3'UTR	NM_001047160.2	NP_001040625.1	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming 1	388	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(4)|kidney(2)|large_intestine(9)|lung(5)|prostate(2)|skin(1)	23						AAGTGCTGCTGTGCCATGGGG	0.522000													29	60					2.65835e-16	2.79452e-16	1	1	0
VPS13D	55187	broad.mit.edu	37	1	12336612	12336612	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:12336612G>A	ENST00000358136.3	+	19	3097	c.2967G>A	c.(2965-2967)aaG>aaA	p.K989K	VPS13D_ENST00000356315.4_Silent_p.K989K	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	989					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACTTTGTGAAGAGGCCTTATG	0.458000											OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	135					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179527365	179527365	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:179527365C>A	ENST00000467460.1	-	12	1576	c.1246G>T	c.(1246-1248)Gct>Tct	p.A416S	PEX5L_ENST00000467440.2_5'UTR|PEX5L_ENST00000476138.1_Missense_Mutation_p.A373S|PEX5L_ENST00000263962.8_Missense_Mutation_p.A414S|PEX5L_ENST00000464614.1_Missense_Mutation_p.A308S|PEX5L_ENST00000468741.1_Missense_Mutation_p.A224S|PEX5L_ENST00000472994.1_Missense_Mutation_p.A357S|PEX5L_ENST00000485199.1_Missense_Mutation_p.A381S|PEX5L_ENST00000392649.3_Missense_Mutation_p.A308S|PEX5L_ENST00000465751.1_Missense_Mutation_p.A392S	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	416					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TTCTTCAGAGCGTCACAGGCA	0.453000													19	87					8.10497e-08	8.38323e-08	1	1	0
RCAN2	10231	broad.mit.edu	37	6	46216497	46216497	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:46216497T>C	ENST00000371374.1	-	3	553	c.362A>G	c.(361-363)cAa>cGa	p.Q121R	RCAN2_ENST00000405162.1_Missense_Mutation_p.Q121R|RCAN2_ENST00000330430.6_Missense_Mutation_p.Q75R|RCAN2_ENST00000306764.7_Missense_Mutation_p.Q121R	NM_001251974.1	NP_001238903.1	Q14206	RCAN2_HUMAN	regulator of calcineurin 2	75					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						CCCTCTGAATTGGGTTTCATG	0.363000													4	52					0	0	1	0	0
SFI1	9814	broad.mit.edu	37	22	31969138	31969138	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:31969138G>A	ENST00000432498.1	+	9	1253	c.860G>A	c.(859-861)cGg>cAg	p.R287Q	SFI1_ENST00000443326.1_Missense_Mutation_p.R205Q|SFI1_ENST00000540643.1_Missense_Mutation_p.R263Q|SFI1_ENST00000414585.1_Missense_Mutation_p.R134Q|SFI1_ENST00000400288.2_Missense_Mutation_p.R287Q|SFI1_ENST00000400289.1_Missense_Mutation_p.R205Q|SFI1_ENST00000443011.1_Missense_Mutation_p.R134Q	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	287					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						TGGCAAAAACGGAGATTTCTA	0.493000											OREG0003525	type=REGULATORY REGION|Gene=SFI1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	11	72					0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18234037	18234037	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:18234037C>T	ENST00000262811.6	+	6	323	c.323C>T	c.(322-324)tCc>tTc	p.S108F	MAST3_ENST00000608648.1_3'UTR	NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3		Poly-Ser.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						TCAAGCTCATCCTCCCGGGAA	0.612000													4	39					0	0	1	0	0
TCTN2	79867	broad.mit.edu	37	12	124179519	124179519	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:124179519G>A	ENST00000303372.5	+	10	1358	c.1230G>A	c.(1228-1230)caG>caA	p.Q410Q	TCTN2_ENST00000426174.2_Silent_p.Q409Q	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	410					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		ATGCCCACCAGAAAGGTAACT	0.299000													21	54					0	0	1	0	0
PDE4B	5142	broad.mit.edu	37	1	66798111	66798111	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:66798111C>T	ENST00000371045.5	+	1	425	c.39C>T	c.(37-39)atC>atT	p.I13I	PDE4B_ENST00000423207.2_Intron|PDE4B_ENST00000329654.4_Intron|PDE4B_ENST00000371049.3_Intron	NM_001037339.1	NP_001032416.1	Q07343	PDE4B_HUMAN	phosphodiesterase 4B, cAMP-specific	189					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	37					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	GCACCGGAATCAGCGGTGGTA	0.522000													8	61					0	0	1	0	0
TFDP2	7029	broad.mit.edu	37	3	141697415	141697415	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:141697415C>T	ENST00000499676.2	-	7	954	c.283G>A	c.(283-285)Gat>Aat	p.D95N	TFDP2_ENST00000495310.1_Missense_Mutation_p.D59N|TFDP2_ENST00000317104.7_Missense_Mutation_p.D79N|TFDP2_ENST00000489671.1_Missense_Mutation_p.D156N|TFDP2_ENST00000464782.1_5'UTR|TFDP2_ENST00000467072.1_Missense_Mutation_p.D95N|TFDP2_ENST00000310282.6_Missense_Mutation_p.D95N|TFDP2_ENST00000479040.1_Missense_Mutation_p.D95N|TFDP2_ENST00000486111.1_Missense_Mutation_p.D95N|TFDP2_ENST00000477292.1_Missense_Mutation_p.D20N|TFDP2_ENST00000397991.4_Missense_Mutation_p.D128N	NM_001178139.1	NP_001171610.1	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization partner 2)	156					cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)|upper_aerodigestive_tract(2)	3						ACCAGCTCATCAGCGACTTCA	0.383000													9	87					0	0	1	0	0
DGAT2	84649	broad.mit.edu	37	11	75509419	75509419	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:75509419C>G	ENST00000228027.7	+	7	1217	c.957C>G	c.(955-957)ctC>ctG	p.L319L	DGAT2_ENST00000376262.3_Silent_p.L276L	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	319					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					GTCGAGGCCTCTTCTCCTCCG	0.587000													7	39					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1940370	1940370	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:1940370G>C	ENST00000543818.1	+	4	1179	c.337G>C	c.(337-339)Ggg>Cgg	p.G113R	LRTM2_ENST00000299194.1_Missense_Mutation_p.G113R|CACNA2D4_ENST00000585732.1_Intron|LRTM2_ENST00000543730.1_Intron|CACNA2D4_ENST00000585708.1_Intron|LRTM2_ENST00000535041.1_Missense_Mutation_p.G113R|CACNA2D4_ENST00000588077.1_Intron|CACNA2D4_ENST00000382722.5_Intron|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000587995.1_Intron	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	113						integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CTCCATTTTCGGGGACCTGAC	0.632000													5	80					0	0	1	0	0
TRPV2	51393	broad.mit.edu	37	17	16332186	16332186	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:16332186G>A	ENST00000338560.7	+	10	1876	c.1477G>A	c.(1477-1479)Gag>Aag	p.E493K	TRPV2_ENST00000583241.1_3'UTR|TRPV2_ENST00000577397.1_Missense_Mutation_p.E63K	NM_016113.4	NP_057197.2	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel, subfamily V, member 2	493					sensory perception	integral to plasma membrane|melanosome	calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|stomach(3)	28				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CCTGGCCATCGAGTGGTACCT	0.597000													13	97					0	0	1	0	0
PACSIN1	29993	broad.mit.edu	37	6	34499518	34499518	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:34499518C>T	ENST00000538621.1	+	9	1424	c.1179C>T	c.(1177-1179)ctC>ctT	p.L393L	PACSIN1_ENST00000244458.2_Silent_p.L393L|PACSIN1_ENST00000374043.2_Silent_p.L351L	NM_001199583.2	NP_001186512.1	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in neurons 1	393	SH3.				endocytosis		protein kinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)	13						TGCGGGCACTCTACGACTATG	0.652000													4	122					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24818054	24818054	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:24818054G>A	ENST00000395799.3	+	17	4618	c.4489G>A	c.(4489-4491)Gag>Aag	p.E1497K	TNRC6A_ENST00000315183.7_Missense_Mutation_p.E1448K|CTD-2515A14.1_ENST00000568895.1_RNA	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1497					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		CACTACACCTGAGCTGCAAAA	0.502000													13	46					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52566060	52566060	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:52566060T>C	ENST00000313234.5	-	7	1197	c.1100A>G	c.(1099-1101)cAg>cGg	p.Q367R	KRT80_ENST00000394815.2_Missense_Mutation_p.Q367R	NM_001081492.1	NP_001074961.1	Q6KB66	K2C80_HUMAN	keratin 80	367	Coil 2.|Rod.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		CATCAGCTCCTGGTACTTGCG	0.657000													17	83					0	0	1	0	0
RFWD2	64326	broad.mit.edu	37	1	176085807	176085807	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:176085807C>T	ENST00000367669.3	-	9	1493	c.979G>A	c.(979-981)Gat>Aat	p.D327N	RFWD2_ENST00000308769.8_Missense_Mutation_p.D303N	NM_022457.5	NP_071902.2	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	327					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						TCTGTGGAATCAATAATACTA	0.303000													33	97					0	0	1	0	0
METTL14	57721	broad.mit.edu	37	4	119618339	119618339	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:119618339A>G	ENST00000388822.5	+	7	673	c.506A>G	c.(505-507)tAc>tGc	p.Y169C	METTL14_ENST00000506780.1_Missense_Mutation_p.Y131C			Q9HCE5	MTL14_HUMAN	methyltransferase like 14							nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)	16						TCAAATAGGTACTTACAAGCC	0.303000													14	38					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177906631	177906631	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:177906631C>T	ENST00000308284.6	-	19	2310	c.2221G>A	c.(2221-2223)Gac>Aac	p.D741N	RP4-798P15.3_ENST00000354921.3_RNA	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	741					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						CCAGAAAAGTCCTGGTAGAAA	0.512000													9	10					0	0	1	0	0
TTC21A	199223	broad.mit.edu	37	3	39162529	39162529	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:39162529C>T	ENST00000301819.6	+	9	1143	c.966C>T	c.(964-966)ttC>ttT	p.F322F	TTC21A_ENST00000431162.2_Silent_p.F322F|TTC21A_ENST00000440121.1_Silent_p.F273F	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	322							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TGTGTAGTTTCATCGAGCGCA	0.522000													21	127					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116617054	116617054	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:116617054G>A	ENST00000395715.3	-	4	1719	c.1142C>T	c.(1141-1143)tCc>tTc	p.S381F	TRPS1_ENST00000220888.5_Missense_Mutation_p.S368F|TRPS1_ENST00000519076.1_Missense_Mutation_p.S322F|TRPS1_ENST00000519674.1_Missense_Mutation_p.S368F|TRPS1_ENST00000520276.1_Missense_Mutation_p.S372F	NM_001282902.1|NM_001282903.1|NM_014112.2	NP_001269831.1|NP_001269832.1|NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	368					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AACCTCAGAGGAGGGGAGAGA	0.408000									Langer-Giedion syndrome				10	56					0	0	1	0	0
PRRX1	5396	broad.mit.edu	37	1	170633534	170633534	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:170633534G>A	ENST00000239461.6	+	1	488	c.175G>A	c.(175-177)Gag>Aag	p.E59K	PRRX1_ENST00000497230.2_Missense_Mutation_p.E59K|PRRX1_ENST00000367760.3_Missense_Mutation_p.E59K	NM_022716.2	NP_073207.1	P54821	PRRX1_HUMAN	paired related homeobox 1	59						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GAACGTGGGCGAGGCTGGCCG	0.672000													5	13					0	0	1	0	0
MIR517A	574479	broad.mit.edu	37	19	54215605	54215605	+	RNA	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:54215605G>C	ENST00000385001.1	+	0	84					NR_030201.1																						GTTACTGTTTGAGACAAGCAA	0.413000													5	79					0	0	1	0	0
HOXA1	3198	broad.mit.edu	37	7	27134936	27134936	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:27134936G>A	ENST00000343060.4	-	1	657	c.596C>T	c.(595-597)tCt>tTt	p.S199F	HOXA1_ENST00000355633.5_Silent_p.I131I	NM_005522.4	NP_005513	P49639	HXA1_HUMAN	homeobox A1	199						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CGCTGGAGAAGATGTCTCCGA	0.542000													17	50					0	0	1	0	0
SEC24D	9871	broad.mit.edu	37	4	119660367	119660367	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:119660367G>A	ENST00000379735.5	-	18	2588	c.2317C>T	c.(2317-2319)Cag>Tag	p.Q773*	SEC24D_ENST00000280551.6_Nonsense_Mutation_p.Q772*|SEC24D_ENST00000505134.1_5'UTR|SEC24D_ENST00000429811.2_Nonsense_Mutation_p.Q328*|SEC24D_ENST00000511481.1_Nonsense_Mutation_p.Q403*|SEC24D_ENST00000419654.2_Nonsense_Mutation_p.Q328*	NM_014822.2	NP_055637.2	O94855	SC24D_HUMAN	SEC24 family member D	772					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37						TCAGCTAGCTGAGAGCTGCAG	0.433000													13	54					0	0	1	0	0
CENPT	80152	broad.mit.edu	37	16	67863736	67863736	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:67863736G>A	ENST00000562787.1	-	12	1666	c.1118C>T	c.(1117-1119)tCc>tTc	p.S373F	CENPT_ENST00000564817.1_Intron|CENPT_ENST00000440851.2_Missense_Mutation_p.S373F|CENPT_ENST00000219172.3_Missense_Mutation_p.S373F	NM_025082.3	NP_079358.3	Q96BT3	CENPT_HUMAN	centromere protein T	373					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding			NS(1)|breast(2)|lung(6)|urinary_tract(1)	10		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		AGTCCCCTGGGATCCCTCTGC	0.597000													8	128					0	0	1	0	0
FAM203A	51236	broad.mit.edu	37	8	145193701	145193701	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:145193701G>A	ENST00000347708.4	+	3	845	c.778G>A	c.(778-780)Gag>Aag	p.E260K		NM_016458.2	NP_057542.2	Q9BTY7	F203A_HUMAN	family with sequence similarity 203, member A	260							binding			endometrium(1)	1						GGATTTCTCCGAGGAAGAGAT	0.602000													6	37					0	0	1	0	0
MRPS18C	51023	broad.mit.edu	37	4	84379565	84379565	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:84379565G>A	ENST00000295491.4	+	3	330	c.217G>A	c.(217-219)Gat>Aat	p.D73N	MRPS18C_ENST00000507349.1_Intron|MRPS18C_ENST00000507019.1_Intron	NM_016067.2	NP_057151.1	Q9Y3D5	RT18C_HUMAN	mitochondrial ribosomal protein S18C	73					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5		Hepatocellular(203;0.114)				AAAGCATGTAGATTATAAGAA	0.328000													6	29					0	0	1	0	0
C19orf26	255057	broad.mit.edu	37	19	1230915	1230915	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:1230915C>T	ENST00000590083.1	-	9	1631	c.1339G>A	c.(1339-1341)Ggg>Agg	p.G447R	C19orf26_ENST00000382477.2_Intron|C19orf26_ENST00000215376.6_Missense_Mutation_p.G441R			Q8N350	DOS_HUMAN	chromosome 19 open reading frame 26	266						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCTGCTTCCCTCCTCTGGTC	0.701000										HNSCC(14;0.022)			11	41					0	0	1	0	0
SPDYA	245711	broad.mit.edu	37	2	29038939	29038939	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:29038939C>T	ENST00000334056.5	+	3	248	c.59C>T	c.(58-60)tCa>tTa	p.S20L	SPDYA_ENST00000379579.4_Missense_Mutation_p.S20L|SPDYA_ENST00000462832.1_3'UTR	NM_182756.3	NP_877433.2	Q5MJ70	SPDYA_HUMAN	speedy/RINGO cell cycle regulator family member A	20					G1/S transition of mitotic cell cycle|multicellular organismal development|positive regulation of cell proliferation|response to DNA damage stimulus	nucleus	protein kinase binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(172;0.155)					TATGTAAAATCAGGGTCAAAT	0.338000													21	71					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108180963	108180963	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:108180963T>C	ENST00000278616.4	+	39	6224	c.5839T>C	c.(5839-5841)Tct>Cct	p.S1947P	ATM_ENST00000452508.2_Missense_Mutation_p.S1947P|C11orf65_ENST00000525729.1_Intron	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1947					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GGTAGCTCAGTCTTGTGCTGC	0.328000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			18	42					0	0	1	0	0
ZMYND12	84217	broad.mit.edu	37	1	42898913	42898913	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:42898913C>A	ENST00000372565.3	-	7	1145	c.876G>T	c.(874-876)ttG>ttT	p.L292F	ZMYND12_ENST00000433602.2_Missense_Mutation_p.L182F|ZMYND12_ENST00000475426.1_5'UTR	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	292						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTCGAATGTTCAAGATTGAAG	0.438000													21	591					1.64293e-13	1.71943e-13	1	1	0
VRK3	51231	broad.mit.edu	37	19	50519312	50519312	+	Silent	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:50519312G>T	ENST00000599538.1	-	3	772	c.108C>A	c.(106-108)acC>acA	p.T36T	VRK3_ENST00000593919.1_Silent_p.T36T|VRK3_ENST00000594092.1_Silent_p.T36T|VRK3_ENST00000601912.1_Silent_p.T36T|VRK3_ENST00000594948.1_Silent_p.T36T|VRK3_ENST00000443401.2_5'UTR|VRK3_ENST00000601341.1_Silent_p.T36T|VRK3_ENST00000316763.3_Silent_p.T36T|VRK3_ENST00000377011.2_Silent_p.T36T|VRK3_ENST00000424804.2_5'UTR			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	36						nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		GATTGACAAAGGTCTGGGACC	0.498000													15	109					0.000308642	0.000314189	1	1	0
EIF4G3	8672	broad.mit.edu	37	1	21137340	21137340	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:21137340G>A	ENST00000602326.1	-	34	5068	c.4485C>T	c.(4483-4485)atC>atT	p.I1495I	EIF4G3_ENST00000536266.1_Silent_p.I1093I|EIF4G3_ENST00000374937.3_Silent_p.I1495I|EIF4G3_ENST00000400422.1_Silent_p.I1489I|EIF4G3_ENST00000264211.8_Silent_p.I1489I|EIF4G3_ENST00000374935.3_Silent_p.I1209I|EIF4G3_ENST00000537738.1_Silent_p.I979I	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	1489	EIF4A-binding (By similarity).|W2.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CTCTCTGCTTGATAACAGCAG	0.383000													16	62					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160690594	160690594	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:160690594T>G	ENST00000263636.4	-	27	3829	c.3802A>C	c.(3802-3804)Aca>Cca	p.T1268P	LY75_ENST00000554112.1_Missense_Mutation_p.T1268P|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.T1268P|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.T1268P|LY75_ENST00000553424.1_Missense_Mutation_p.T1268P	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TCCTGTGTTGTTGCCATATGC	0.363000													21	61					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62243223	62243223	+	Splice_Site	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:62243223T>G	ENST00000261517.5	-	40	4530	c.4457A>C	c.(4456-4458)gAc>gCc	p.D1486A	VPS13C_ENST00000249837.3_Splice_Site_p.D1443A|VPS13C_ENST00000395898.3_Splice_Site_p.D1443A|VPS13C_ENST00000395896.4_Splice_Site_p.D1486A	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	1486					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						CCCTTTAGAGTCTAAAAGAGA	0.333000													7	25					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94568618	94568618	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:94568618C>T	ENST00000370225.3	-	5	609	c.523G>A	c.(523-525)Gac>Aac	p.D175N	ABCA4_ENST00000535735.1_Missense_Mutation_p.D175N	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	175					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		ACCACTGAGTCAGACAGGCCG	0.473000													20	174					0	0	1	0	0
TRAV1-1	28693	broad.mit.edu	37	14	22090709	22090709	+	RNA	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:22090709C>T	ENST00000542354.1	+	0	381																											CTTACTTCTGCGCTGTGAGAG	0.458000													5	25					0	0	1	0	0
PLK4	10733	broad.mit.edu	37	4	128806936	128806936	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:128806936C>G	ENST00000270861.5	+	5	685	c.411C>G	c.(409-411)ctC>ctG	p.L137L	PLK4_ENST00000513090.1_Silent_p.L105L|PLK4_ENST00000507249.1_Silent_p.L137L|PLK4_ENST00000515069.1_Silent_p.L137L|PLK4_ENST00000514379.1_Silent_p.L96L	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	137	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						ACCGGGACCTCACACTTTCTA	0.398000													4	97					0	0	1	0	0
OR3A2	4995	broad.mit.edu	37	17	3181368	3181368	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:3181368T>C	ENST00000408891.2	-	1	900	c.862A>G	c.(862-864)Act>Gct	p.T288A		NM_002551.3	NP_002542.3	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A, member 2	288					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						TTGATAACAGTGTTGAAAACT	0.458000													4	83					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86591013	86591013	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:86591013C>T	ENST00000370571.2	-	3	1372	c.1006G>A	c.(1006-1008)Gaa>Aaa	p.E336K	COL24A1_ENST00000436319.1_Missense_Mutation_p.E336K	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	336					cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		GTGATCATTTCTTTGGCCTGA	0.408000													10	89					0	0	1	0	0
RAB8B	51762	broad.mit.edu	37	15	63554899	63554899	+	Silent	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:63554899T>C	ENST00000321437.4	+	7	645	c.489T>C	c.(487-489)ttT>ttC	p.F163F	RAB8B_ENST00000448330.2_Intron	NM_016530.2	NP_057614.1	Q92930	RAB8B_HUMAN	RAB8B, member RAS oncogene family	163					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			kidney(3)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9						AGGCATTTTTTACACTTGCAC	0.264000													9	35					0	0	1	0	0
SPN	6693	broad.mit.edu	37	16	29675230	29675230	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:29675230C>T	ENST00000360121.3	+	2	273	c.181C>T	c.(181-183)Cag>Tag	p.Q61*	SPN_ENST00000395389.2_Nonsense_Mutation_p.Q61*	NM_001030288.2|NM_003123.4	NP_001025459.1|NP_003114.1	P16150	LEUK_HUMAN	sialophorin	61					blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|stomach(1)	15						CACTGGGGACCAGACCTCAGC	0.547000													12	95					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179471981	179471981	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:179471981A>G	ENST00000589042.1	-	278	53572	c.53348T>C	c.(53347-53349)cTt>cCt	p.L17783P	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.L8910P|TTN_ENST00000591111.1_Missense_Mutation_p.L16142P|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.L15215P|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.L8843P|TTN_ENST00000460472.2_Missense_Mutation_p.L8718P	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16142	Ig-like 104.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGACCAGTTAAGTAGACACAT	0.358000													12	60					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1083807	1083807	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:1083807G>A	ENST00000441003.2	+	18	2366	c.2339G>A	c.(2338-2340)cGa>cAa	p.R780Q	MUC2_ENST00000359061.5_Missense_Mutation_p.R780Q	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	780						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TCGAAGCCCCGAGCCCTCAGC	0.682000													3	19					0	0	1	0	0
COG3	83548	broad.mit.edu	37	13	46054407	46054407	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:46054407A>G	ENST00000349995.5	+	4	643	c.531A>G	c.(529-531)gaA>gaG	p.E177E		NM_031431.3	NP_113619	Q96JB2	COG3_HUMAN	component of oligomeric golgi complex 3	177					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|skin(2)|stomach(1)	24		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		AAGCCTGTGAACAGCTCCTAA	0.323000													7	43					0	0	1	0	0
NAMPT	10135	broad.mit.edu	37	7	105903860	105903860	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:105903860T>C	ENST00000222553.3	-	7	1254	c.947A>G	c.(946-948)aAc>aGc	p.N316S	NAMPT_ENST00000354289.4_Missense_Mutation_p.N316S	NM_005746.2	NP_005737.1	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	316					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14						GTCAAGAGGGTTTCCAGAATC	0.338000													9	38					0	0	1	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88940389	88940389	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:88940389G>T	ENST00000375961.2	-	12	1863	c.1649C>A	c.(1648-1650)cCa>cAa	p.P550Q	ZCCHC6_ENST00000375960.2_Missense_Mutation_p.P427Q|ZCCHC6_ENST00000375963.3_Missense_Mutation_p.P550Q|ZCCHC6_ENST00000277141.6_5'UTR			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	550					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						CTGCCCAACTGGTACTGAAGG	0.373000													10	28					9.70103e-10	1.01005e-09	1	1	0
TNFRSF1B	7133	broad.mit.edu	37	1	12251106	12251106	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:12251106C>T	ENST00000376259.3	+	3	360	c.271C>T	c.(271-273)Ccc>Tcc	p.P91S	TNFRSF1B_ENST00000492361.1_3'UTR|TNFRSF1B_ENST00000536782.1_Missense_Mutation_p.P91S	NM_001066.2	NP_001057.1	P20333	TNR1B_HUMAN	tumor necrosis factor receptor superfamily, member 1B	91					apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(1)|liver(1)|lung(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	GAACTGGGTTCCCGAGTGCTT	0.572000													29	92					0	0	1	0	0
IKBKB	3551	broad.mit.edu	37	8	42129600	42129600	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:42129600G>A	ENST00000520810.1	+	2	168		c.e2-1		IKBKB_ENST00000520835.1_Intron|IKBKB_ENST00000416505.2_Splice_Site|IKBKB_ENST00000519735.1_Splice_Site|IKBKB_ENST00000379708.3_Splice_Site|IKBKB_ENST00000522147.1_5'UTR|IKBKB_ENST00000518983.1_Splice_Site	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta						anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	ATTGCTTATAGAGTTAGCACG	0.478000											OREG0018746	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	33					0	0	1	0	0
DNAJB11	51726	broad.mit.edu	37	3	186301674	186301674	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:186301674G>A	ENST00000439351.1	+	9	1690	c.761G>A	c.(760-762)aGa>aAa	p.R254K	DNAJB11_ENST00000265028.3_Missense_Mutation_p.R254K			Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	254					protein folding	endoplasmic reticulum lumen	heat shock protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|urinary_tract(2)	15	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		TTTGAAAGGAGAGGAGATGAT	0.338000													12	53					0	0	1	0	0
RGR	5995	broad.mit.edu	37	10	86004864	86004864	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:86004864C>T	ENST00000359452.4	+	1	56	c.18C>T	c.(16-18)gcC>gcT	p.A6A	RGR_ENST00000372092.3_Silent_p.A6A|RGR_ENST00000358110.5_Silent_p.A6A	NM_001012720.1|NM_002921.3	NP_001012738.1|NP_002912.2	P47804	RGR_HUMAN	retinal G protein coupled receptor	6					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	17						AGACCAGTGCCCTGCCCACTG	0.647000													8	55					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39763635	39763635	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:39763635G>C	ENST00000395670.3	-	3	765	c.346C>G	c.(346-348)Cga>Gga	p.R116G	KIF21A_ENST00000541463.2_Missense_Mutation_p.R116G|KIF21A_ENST00000544797.2_Missense_Mutation_p.R116G|KIF21A_ENST00000361961.3_Missense_Mutation_p.R116G|KIF21A_ENST00000361418.5_Missense_Mutation_p.R116G			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	116	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TTAACAGCTCGAGAAATAATA	0.348000													10	38					0	0	1	0	0
APPBP2	10513	broad.mit.edu	37	17	58603262	58603262	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:58603262C>T	ENST00000083182.3	-	1	318	c.31G>A	c.(31-33)Gag>Aag	p.E11K		NM_001282476.1|NM_006380.2	NP_001269405.1|NP_006371.2	Q92624	APBP2_HUMAN	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	11					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(17)|pancreas(1)|urinary_tract(1)	25	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			TAGAGAGTCTCTGGGATCCAC	0.607000													8	19					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70279261	70279261	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:70279261G>A	ENST00000301843.8	+	16	1527	c.1321G>A	c.(1321-1323)Gag>Aag	p.E441K	CTTN_ENST00000346329.3_Missense_Mutation_p.E404K|CTTN_ENST00000538675.1_Missense_Mutation_p.E125K|CTTN_ENST00000376561.3_Missense_Mutation_p.E404K	NM_005231.3	NP_005222.2	Q14247	SRC8_HUMAN	cortactin	441						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		GAGTGGGACGGAGCCGGAGCC	0.642000													4	49					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137917851	137917851	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:137917851C>T	ENST00000409968.1	+	6	1616	c.1438C>T	c.(1438-1440)Cct>Tct	p.P480S	THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.P449S|THSD7B_ENST00000272643.3_Missense_Mutation_p.P480S|THSD7B_ENST00000485379.1_3'UTR					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CTGCAATATCCCTTGCTCTAC	0.517000													9	53					0	0	1	0	0
RABGAP1L	9910	broad.mit.edu	37	1	174188322	174188322	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:174188322G>A	ENST00000357444.6	+	2	308	c.27G>A	c.(25-27)aaG>aaA	p.K9K	RABGAP1L_ENST00000367689.3_5'UTR|RABGAP1L_ENST00000251507.4_Silent_p.K9K			Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like	46					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity	p.K9K(1)		NS(1)|breast(2)|endometrium(4)|kidney(5)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(2)	45						CATTACAGAAGGTTAGTGGAT	0.363000													9	49					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135025069	135025069	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:135025069C>G	ENST00000304613.3	+	22	4073	c.4052C>G	c.(4051-4053)tCc>tGc	p.S1351C	KNDC1_ENST00000368572.2_Missense_Mutation_p.S1353C			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1351	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TTCATCTCCTCCAAGGTGACA	0.682000													12	61					0	0	1	0	0
ARNT2	9915	broad.mit.edu	37	15	80872851	80872851	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:80872851G>T	ENST00000533983.1	+	17	2019	c.1680G>T	c.(1678-1680)caG>caT	p.Q560H	RP11-379K22.3_ENST00000603875.1_RNA|ARNT2_ENST00000527771.1_Missense_Mutation_p.Q560H|ARNT2_ENST00000303329.4_Missense_Mutation_p.Q571H			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	571					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			ACCAGAGTCAGGTGGCATGGA	0.572000													11	46					1.58986e-06	1.63727e-06	1	1	0
GRK5	2869	broad.mit.edu	37	10	121207647	121207647	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:121207647G>C	ENST00000392870.2	+	13	1608	c.1279G>C	c.(1279-1281)Gat>Cat	p.D427H	GRK5_ENST00000369108.3_Missense_Mutation_p.D322H	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	427	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GCTCACGAAAGATGCGAAGCA	0.597000													9	83					0	0	1	0	0
RIN2	54453	broad.mit.edu	37	20	19981338	19981338	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:19981338G>A	ENST00000255006.6	+	12	2742	c.2593G>A	c.(2593-2595)Gag>Aag	p.E865K	RIN2_ENST00000440354.2_Missense_Mutation_p.E383K|RIN2_ENST00000484638.1_3'UTR	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	816	Ras-associating.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						CATCACCACTGAGGATGTGTG	0.522000													7	126					0	0	1	0	0
ARHGAP19-SLIT1	100533184	broad.mit.edu	37	10	99003769	99003769	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:99003769G>A	ENST00000453547.2	-	8	1140	c.1141C>T	c.(1141-1143)Cat>Tat	p.H381Y	ARHGAP19_ENST00000487035.1_5'UTR|ARHGAP19_ENST00000358531.4_Missense_Mutation_p.H381Y|ARHGAP19_ENST00000355366.5_Missense_Mutation_p.H372Y|ARHGAP19-SLIT1_ENST00000358308.3_Missense_Mutation_p.H352Y|ARHGAP19-SLIT1_ENST00000316676.8_Missense_Mutation_p.H381Y|ARHGAP19_ENST00000371027.1_Missense_Mutation_p.H372Y																							GGCATATCATGAACGTGTTGA	0.498000													18	56					0	0	1	0	0
OGDH	4967	broad.mit.edu	37	7	44735681	44735681	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:44735681G>A	ENST00000222673.5	+	13	1768	c.1726G>A	c.(1726-1728)Gag>Aag	p.E576K	OGDH_ENST00000439616.2_Missense_Mutation_p.E426K|OGDH_ENST00000543843.1_Missense_Mutation_p.E527K|OGDH_ENST00000447398.1_Missense_Mutation_p.E587K|OGDH_ENST00000444676.1_Missense_Mutation_p.E591K|OGDH_ENST00000449767.1_Missense_Mutation_p.E572K	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	576					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	ATCTAAAGATGAGAAGATCTT	0.483000													15	36					0	0	1	0	0
SMEK1	55671	broad.mit.edu	37	14	91928498	91928498	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:91928498C>T	ENST00000554684.1	-	13	2516	c.2020G>A	c.(2020-2022)Gaa>Aaa	p.E674K	SMEK1_ENST00000554943.1_Missense_Mutation_p.E687K|SMEK1_ENST00000555462.1_Missense_Mutation_p.E448K|SMEK1_ENST00000555718.1_5'UTR|SMEK1_ENST00000337238.4_Missense_Mutation_p.E674K|SMEK1_ENST00000428424.2_Missense_Mutation_p.E448K	NM_001284280.1	NP_001271209.1	Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	687						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|liver(1)|lung(1)|stomach(1)	6		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		ATGTCATCTTCATCTGTGTTA	0.373000													8	22					0	0	1	0	0
RNF25	64320	broad.mit.edu	37	2	219529467	219529467	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:219529467G>A	ENST00000295704.2	-	9	1236	c.796C>T	c.(796-798)Cag>Tag	p.Q266*		NM_022453.2	NP_071898.2	Q96BH1	RNF25_HUMAN	ring finger protein 25	266					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCACCTGCTGAAGGCTGATG	0.557000													14	49					0	0	1	0	0
ZNF623	9831	broad.mit.edu	37	8	144733242	144733242	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:144733242G>C	ENST00000501748.2	+	1	1289	c.1200G>C	c.(1198-1200)gaG>gaC	p.E400D	ZNF623_ENST00000526926.1_Missense_Mutation_p.E360D|ZNF623_ENST00000458270.2_Missense_Mutation_p.E360D	NM_014789.3	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(6)|lung(11)|prostate(1)|stomach(1)|urinary_tract(3)	27	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			ACACTGGAGAGAGAGTGTATG	0.453000													14	84					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75230877	75230877	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:75230877C>T	ENST00000325680.7	+	1	809	c.685C>T	c.(685-687)Cag>Tag	p.Q229*	YLPM1_ENST00000552421.1_Nonsense_Mutation_p.Q229*|YLPM1_ENST00000238571.3_Nonsense_Mutation_p.Q229*	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	69					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GCCCTCTTCTCAGGCATCTCC	0.567000													7	46					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9810700	9810700	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:9810700C>T	ENST00000256190.8	-	35	5025	c.4888G>A	c.(4888-4890)Gat>Aat	p.D1630N	SBF2-AS1_ENST00000525636.1_RNA|SBF2-AS1_ENST00000534671.1_RNA|SBF2-AS1_ENST00000499953.2_RNA|SBF2-AS1_ENST00000526617.1_RNA|SBF2-AS1_ENST00000498905.2_RNA	NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1630	Interaction with MTMR2.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CAGCTGACATCATCATAGCAT	0.572000													14	28					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245775271	245775271	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:245775271A>C	ENST00000366518.4	+	6	1052	c.948A>C	c.(946-948)aaA>aaC	p.K316N	KIF26B_ENST00000407071.2_Missense_Mutation_p.K697N			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	697					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGAGCGGGAAAGGGGGAAGTA	0.577000													4	31					0	0	1	0	0
GPAA1	8733	broad.mit.edu	37	8	145138363	145138363	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:145138363C>T	ENST00000355091.4	+	3	447	c.326C>T	c.(325-327)tCc>tTc	p.S109F	GPAA1_ENST00000527144.1_3'UTR|GPAA1_ENST00000361036.6_Missense_Mutation_p.S49F	NM_003801.3	NP_003792.1	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment 1	109					attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(2)	19	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CAGAGTTTCTCCCGGAAACTG	0.632000													6	83					0	0	1	0	0
MARCKSL1	65108	broad.mit.edu	37	1	32800504	32800504	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:32800504G>A	ENST00000329421.7	-	2	627	c.282C>T	c.(280-282)ttC>ttT	p.F94F		NM_023009.6	NP_075385.1	P49006	MRP_HUMAN	MARCKS-like 1	94	Calmodulin-binding (PSD).					plasma membrane	calmodulin binding			breast(1)|large_intestine(3)|lung(1)|ovary(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				AAGGCTTCTTGAAAGAGAATT	0.577000													5	32					0	0	1	0	0
SLC38A3	10991	broad.mit.edu	37	3	50256319	50256319	+	RNA	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:50256319C>T	ENST00000420502.1	+	0	1398							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	TTGGCCTGCTCACTTGTATCA	0.597000													11	49					0	0	1	0	0
SYT1	6857	broad.mit.edu	37	12	79842878	79842878	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:79842878G>A	ENST00000261205.4	+	11	1900	c.1243G>A	c.(1243-1245)Gat>Aat	p.D415N	SYT1_ENST00000457153.2_Missense_Mutation_p.D412N|RP1-78O14.1_ENST00000550268.1_lincRNA|SYT1_ENST00000552744.1_Missense_Mutation_p.D415N|SYT1_ENST00000393240.3_Missense_Mutation_p.D415N	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	415					detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						GGAGGAAGTTGATGCCATGCT	0.522000													3	19					0	0	1	0	0
SSH3	54961	broad.mit.edu	37	11	67074372	67074372	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:67074372G>A	ENST00000308127.4	+	4	581	c.403G>A	c.(403-405)Gaa>Aaa	p.E135K	SSH3_ENST00000376757.5_Missense_Mutation_p.E135K|SSH3_ENST00000532181.1_3'UTR|SSH3_ENST00000308298.7_Missense_Mutation_p.E135K	NM_017857.3	NP_060327.3	Q8TE77	SSH3_HUMAN	slingshot protein phosphatase 3	135					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			TTCTACACGAGAAGGAGAAGG	0.637000													5	26					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306688	54306688	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:54306688G>A	ENST00000545554.1	+	1	1588	c.1588G>A	c.(1588-1590)Gat>Aat	p.D530N	UNC13C_ENST00000537900.1_Missense_Mutation_p.D530N|UNC13C_ENST00000260323.11_Missense_Mutation_p.D530N			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	530					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CCATTATGCAGATGCAACACC	0.368000													12	50					0	0	1	0	0
STAG3	10734	broad.mit.edu	37	7	99798091	99798091	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:99798091G>A	ENST00000426455.1	+	18	2193	c.1786G>A	c.(1786-1788)Gag>Aag	p.E596K	STAG3_ENST00000317296.5_Missense_Mutation_p.E596K|STAG3_ENST00000394018.2_Missense_Mutation_p.E538K|STAG3_ENST00000440830.1_3'UTR	NM_001282716.1	NP_001269645.1	Q9UJ98	STAG3_HUMAN	stromal antigen 3	596					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(11)|lung(30)|ovary(5)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	66	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGCTGATGCAGAGAAGGTCAC	0.512000													13	54					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36220957	36220957	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:36220957C>T	ENST00000222270.7	+	23	5007	c.5007C>T	c.(5005-5007)gcC>gcT	p.A1669A	KMT2B_ENST00000607650.1_RNA|KMT2B_ENST00000420124.1_Silent_p.A1669A	NM_014727.1	NP_055542.1			lysine (K)-specific methyltransferase 2B																		GTGCCCGGGCCAGCTACTGCA	0.602000													10	21					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109740694	109740694	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:109740694A>G	ENST00000369939.3	+	17	2579	c.2396A>G	c.(2395-2397)tAt>tGt	p.Y799C	KIAA1324_ENST00000529753.1_Missense_Mutation_p.Y712C|KIAA1324_ENST00000369938.1_3'UTR	NM_020775.4	NP_065826	Q6UXG2	K1324_HUMAN	KIAA1324	799					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		ATCTTCTTTTATAGGTGAAGA	0.488000													18	48					0	0	1	0	0
CAPZA1	829	broad.mit.edu	37	1	113201662	113201662	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:113201662G>A	ENST00000263168.3	+	6	1117	c.445G>A	c.(445-447)Gat>Aat	p.D149N	CAPZA1_ENST00000476936.1_3'UTR	NM_006135.2	NP_006126.1	P52907	CAZA1_HUMAN	capping protein (actin filament) muscle Z-line, alpha 1	149					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex|WASH complex	actin binding			breast(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)	9	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TAAAACTATCGATGGGCAACA	0.318000													11	96					0	0	1	0	0
TXLNG	55787	broad.mit.edu	37	X	16846367	16846367	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:16846367C>G	ENST00000380122.5	+	4	710	c.649C>G	c.(649-651)Cgt>Ggt	p.R217G	TXLNG_ENST00000398155.4_Missense_Mutation_p.R85G	NM_018360.2	NP_060830.2	Q9NUQ3	TXLNG_HUMAN	taxilin gamma	217					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane				breast(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	15						AGAACTTCAGCGTCACAATAA	0.398000													4	31					0	0	1	0	0
MFSD8	256471	broad.mit.edu	37	4	128870965	128870965	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:128870965G>A	ENST00000296468.3	-	4	319	c.192C>T	c.(190-192)ctC>ctT	p.L64L	MFSD8_ENST00000515130.1_5'UTR|MFSD8_ENST00000513559.1_Silent_p.L19L|MFSD8_ENST00000541133.1_Silent_p.L19L	NM_152778.2	NP_689991.1	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing 8	64					cell death|transmembrane transport	integral to membrane|lysosomal membrane				cervix(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)	23						AAACCTTTTGGAGATATGGCC	0.303000													46	69					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23411413	23411413	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:23411413A>G	ENST00000379361.4	+	3	2638	c.1778A>G	c.(1777-1779)aAt>aGt	p.N593S		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	593					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						AGCTATTTAAATTACCTTCGG	0.378000													32	45					0	0	1	0	0
C9orf142	286257	broad.mit.edu	37	9	139887404	139887404	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:139887404G>A	ENST00000371620.3	+	3	234	c.208G>A	c.(208-210)Gag>Aag	p.E70K	C9orf142_ENST00000493968.1_3'UTR	NM_183241.1	NP_899064.1	Q9BUH6	CI142_HUMAN	chromosome 9 open reading frame 142	70												all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GAGTGCGGCTGAGGACATCAC	0.657000													5	63					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	191888293	191888293	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:191888293C>T	ENST00000445105.2	-	5	626	c.381G>A	c.(379-381)gtG>gtA	p.V127V	FGF12_ENST00000430714.1_Silent_p.V90V|FGF12_ENST00000264730.3_Silent_p.V127V|FGF12_ENST00000450716.1_Silent_p.V127V|FGF12_ENST00000454309.2_Silent_p.V189V	NM_004113.5	NP_004104.3	P61328	FGF12_HUMAN	fibroblast growth factor 12						cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TGGTTTTCTTCACTCTGTTCC	0.428000													9	135					0	0	1	0	0
KIFC2	90990	broad.mit.edu	37	8	145693284	145693284	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:145693284G>A	ENST00000301332.2	+	7	1101	c.724G>A	c.(724-726)Gag>Aag	p.E242K	KIFC2_ENST00000301331.5_5'UTR	NM_145754.2	NP_665697.1	Q96AC6	KIFC2_HUMAN	kinesin family member C2	242	Gln-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(3)|prostate(3)|skin(2)|urinary_tract(1)	19	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			TCTGACTCTGGAGAACGAGGC	0.662000											OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	16					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50350866	50350866	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:50350866G>A	ENST00000376020.2	-	6	3301	c.3276C>T	c.(3274-3276)ctC>ctT	p.L1092L	SHROOM4_ENST00000289292.7_Silent_p.L1092L|SHROOM4_ENST00000460112.3_Silent_p.L976L	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1092					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					TCCTGGCTCCGAGAAGATCCG	0.602000													5	16					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216017648	216017648	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:216017648G>A	ENST00000366943.2	-	46	9632	c.9246C>T	c.(9244-9246)atC>atT	p.I3082I	USH2A_ENST00000307340.3_Silent_p.I3082I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3082	Fibronectin type-III 17.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GAATGTCATAGATAGTGAAGG	0.368000										HNSCC(13;0.011)			15	25					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186678419	186678419	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:186678419G>A	ENST00000343098.5	+	18	20242	c.20242G>A	c.(20242-20244)Gag>Aag	p.E6748K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E6659K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TTACATAAAAGAGGAACGAGA	0.313000													5	31					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19135978	19135978	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:19135978C>T	ENST00000601879.1	-	3	1476	c.1179G>A	c.(1177-1179)ttG>ttA	p.L393L	SUGP2_ENST00000600377.1_Silent_p.L407L|SUGP2_ENST00000337018.6_Silent_p.L393L|SUGP2_ENST00000456085.2_Silent_p.L162L|SUGP2_ENST00000452918.2_Silent_p.L393L			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	393					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						TGGGTGTTTTCAAAGCAGAGT	0.328000													21	57					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27101531	27101531	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:27101531C>T	ENST00000324856.7	+	18	5184	c.4813C>T	c.(4813-4815)Cca>Tca	p.P1605S	ARID1A_ENST00000540690.1_Intron|ARID1A_ENST00000374152.2_Missense_Mutation_p.P1222S|ARID1A_ENST00000457599.2_Missense_Mutation_p.P1388S	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1605					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TAGCAAGTCTCCATTCCTGCA	0.607000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								8	51					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48613050	48613050	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:48613050G>A	ENST00000297423.4	+	12	2155	c.1771G>A	c.(1771-1773)Gag>Aag	p.E591K	SPIDR_ENST00000517693.1_Missense_Mutation_p.E66K|SPIDR_ENST00000518074.1_Missense_Mutation_p.E531K|SPIDR_ENST00000521214.1_3'UTR|SPIDR_ENST00000541342.1_Missense_Mutation_p.E521K	NM_001080394.2|NM_001282916.1	NP_001073863.1|NP_001269845.1			scaffolding protein involved in DNA repair																		GCCCTGTGAAGAGGTAAGCCC	0.562000													11	59					0	0	1	0	0
CAMTA2	23125	broad.mit.edu	37	17	4889234	4889234	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:4889234C>G	ENST00000361571.5	-	3	556	c.145G>C	c.(145-147)Gag>Cag	p.E49Q	CAMTA2_ENST00000348066.3_Missense_Mutation_p.E26Q|CAMTA2_ENST00000572543.1_Missense_Mutation_p.E26Q|CAMTA2_ENST00000358183.4_Missense_Mutation_p.E26Q|CAMTA2_ENST00000414043.3_Missense_Mutation_p.E49Q|CAMTA2_ENST00000381311.5_Missense_Mutation_p.E28Q	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	26					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						GGAAGACACTCCAGCAGCTTC	0.547000													3	52					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1017272	1017272	+	Silent	SNP	G	G	A	rs71472140		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:1017272G>A	ENST00000421673.2	-	31	5579	c.5529C>T	c.(5527-5529)ttC>ttT	p.F1843F		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1843	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGGAGGTGGAGAAAGATGGAA	0.542000													30	339					0	0	1	0	0
TTC13	79573	broad.mit.edu	37	1	231094014	231094014	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:231094014C>G	ENST00000366661.4	-	3	405	c.398G>C	c.(397-399)aGa>aCa	p.R133T	TTC13_ENST00000366662.4_Missense_Mutation_p.R133T|TTC13_ENST00000414259.1_Missense_Mutation_p.R133T	NM_024525.4	NP_078801.3	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13	133							binding			central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	39	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		AAACGGGAATCTCTTCTGTTC	0.343000													3	47					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332511	22332511	+	RNA	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:22332511T>C	ENST00000558896.1	+	0	318																											TTTGTTTTTTTACATTGCTAT	0.378000													19	79					0	0	1	0	0
LPAR6	10161	broad.mit.edu	37	13	48985729	48985729	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:48985729G>A	ENST00000378434.4	-	7	2455	c.831C>T	c.(829-831)ctC>ctT	p.L277L	RB1_ENST00000267163.4_Intron|LPAR6_ENST00000345941.2_Silent_p.L277L	NM_005767.5	NP_005758.2	P43657	LPAR6_HUMAN	lysophosphatidic acid receptor 6	277						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.0?(15)|p.?(4)		NS(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	14						CAGCAATACAGAGAGTGATTG	0.343000													5	39					0	0	1	0	0
TPRA1	131601	broad.mit.edu	37	3	127294060	127294060	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:127294060G>A	ENST00000296210.7	-	8	972	c.658C>T	c.(658-660)Cat>Tat	p.H220Y	TPRA1_ENST00000355552.3_Silent_p.L274L|TPRA1_ENST00000465915.1_5'UTR|TPRA1_ENST00000489960.1_Silent_p.L274L|TPRA1_ENST00000450633.2_Silent_p.L274L	NM_001142646.1	NP_001136118.1	Q86W33	TPRA1_HUMAN	transmembrane protein, adipocyte asscociated 1	0					aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity			endometrium(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	9						CCACGTAGATGAGCGGAGCGA	0.657000											OREG0015772	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	19					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535849	69535849	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:69535849T>A	ENST00000338206.5	-	1	497	c.488A>T	c.(487-489)gAa>gTa	p.E163V		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	163					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										GTTAAATAGTTCAGCCAGTAG	0.408000													52	166					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213886821	213886821	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:213886821C>T	ENST00000457361.1	-	6	776	c.608G>A	c.(607-609)cGa>cAa	p.R203Q	IKZF2_ENST00000434687.1_Missense_Mutation_p.R203Q|IKZF2_ENST00000413091.3_Missense_Mutation_p.R203Q|IKZF2_ENST00000374327.4_Missense_Mutation_p.R58Q|IKZF2_ENST00000421754.2_Missense_Mutation_p.R177Q|IKZF2_ENST00000451136.2_Intron|IKZF2_ENST00000374319.4_Missense_Mutation_p.R177Q|IKZF2_ENST00000342002.2_Missense_Mutation_p.R209Q	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CTTGTAGCTTCGTCCACAGTA	0.488000													7	47					0	0	1	0	0
ACTG1	71	broad.mit.edu	37	17	79477801	79477801	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:79477801G>A	ENST00000575842.1	-	5	1469	c.1043C>T	c.(1042-1044)tCa>tTa	p.S348L	ACTG1_ENST00000331925.2_Missense_Mutation_p.S348L|ACTG1_ENST00000575087.1_Missense_Mutation_p.S348L|ACTG1_ENST00000573283.1_Missense_Mutation_p.S348L			P63261	ACTG_HUMAN	actin, gamma 1	348					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|lung(8)|ovary(2)|prostate(5)|urinary_tract(1)	29	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			GGTGGACAGTGAGGCCAGGAT	0.592000													24	98					0	0	1	0	0
DEDD	9191	broad.mit.edu	37	1	161092820	161092820	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:161092820C>T	ENST00000392188.1	-	5	859	c.625G>A	c.(625-627)Gaa>Aaa	p.E209K	DEDD_ENST00000545495.1_Intron|DEDD_ENST00000489249.1_Intron|DEDD_ENST00000368006.3_Intron|DEDD_ENST00000490843.2_Intron|NIT1_ENST00000368008.1_Intron|DEDD_ENST00000458050.2_Intron|DEDD_ENST00000368005.1_Missense_Mutation_p.E209K			O75618	DEDD_HUMAN	death effector domain containing	194					apoptosis|induction of apoptosis via death domain receptors|negative regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			cervix(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|skin(1)	10	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TCTTTATATTCTCCTTCAAGT	0.483000													37	127					0	0	1	0	0
KCNE4	23704	broad.mit.edu	37	2	223917755	223917755	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:223917755C>G	ENST00000281830.3	+	2	691	c.360C>G	c.(358-360)ctC>ctG	p.L120L	KCNE4_ENST00000604125.1_Silent_p.L69L|KCNE4_ENST00000488477.2_Intron			Q8WWG9	KCNE4_HUMAN	potassium voltage-gated channel, Isk-related family, member 4	69						integral to membrane	voltage-gated potassium channel activity			large_intestine(2)|lung(5)|ovary(2)|skin(1)	10		Renal(207;0.0183)|Lung NSC(271;0.137)|all_lung(227;0.175)		Epithelial(121;4.48e-11)|all cancers(144;2.88e-08)|Lung(261;0.00688)|LUSC - Lung squamous cell carcinoma(224;0.008)		AGTCCAGCCTCCTGCTGCTGT	0.567000													14	54					0	0	1	0	0
ELP6	54859	broad.mit.edu	37	3	47539848	47539848	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:47539848G>A	ENST00000296149.4	-	6	770	c.600C>T	c.(598-600)ctC>ctT	p.L200L	ELP6_ENST00000446787.1_Silent_p.L127L|ELP6_ENST00000439305.1_Silent_p.L127L	NM_001031703.2	NP_001026873.2			elongator acetyltransferase complex subunit 6																		TCTGATGACTGAGGCCATTCA	0.582000													22	65					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113942559	113942559	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:113942559C>T	ENST00000441564.3	+	3	1251	c.1082C>T	c.(1081-1083)tCt>tTt	p.S361F	PSD4_ENST00000245796.6_Missense_Mutation_p.S361F			Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4						regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCTGCTCCATCTgcagcaccg	0.547000													34	252					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12320849	12320849	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:12320849G>C	ENST00000358136.3	+	11	1340	c.1210G>C	c.(1210-1212)Gag>Cag	p.E404Q	VPS13D_ENST00000356315.4_Missense_Mutation_p.E404Q	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	404					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGAACTAGCAGAGGTAAGAAA	0.448000													7	48					0	0	1	0	0
ZNF439	90594	broad.mit.edu	37	19	11977371	11977371	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:11977371G>C	ENST00000304030.2	+	2	395	c.195G>C	c.(193-195)caG>caC	p.Q65H	ZNF439_ENST00000455282.1_5'UTR|ZNF439_ENST00000592534.1_Intron	NM_152262.2	NP_689475.1	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	65	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(7)|pancreas(1)|skin(2)	27						GGAAAGACCAGAACATTGAAT	0.338000													8	64					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108145672	108145672	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:108145672A>T	ENST00000370056.4	-	23	2403	c.2129T>A	c.(2128-2130)aTt>aAt	p.I710N	VAV3_ENST00000544443.1_Missense_Mutation_p.I114N|VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000527011.1_Missense_Mutation_p.I710N|VAV3_ENST00000415432.2_Missense_Mutation_p.I150N	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	710	SH2.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TACTTACTTAATGCTAATTGC	0.358000													4	96					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67129924	67129924	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:67129924G>A	ENST00000284425.2	-	6	823	c.649C>T	c.(649-651)Ctt>Ttt	p.L217F		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	217					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					TTGTGAAGAAGATTTTTAGTT	0.313000													5	50					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14157414	14157414	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:14157414C>T	ENST00000263379.2	+	8	1250	c.1125C>T	c.(1123-1125)ctC>ctT	p.L375L		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	375	Fibronectin type-III 2.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						CTGGGAACCTCAGTGCTCTGT	0.602000													14	34					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86258485	86258485	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:86258485G>A	ENST00000263857.6	-	30	4924	c.4546C>T	c.(4546-4548)Cag>Tag	p.Q1516*	POLR1A_ENST00000409681.1_Intron			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	1516					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						GTGTCGTACTGGTAGTCATCT	0.662000													8	82					0	0	1	0	0
IMPDH2	3615	broad.mit.edu	37	3	49064314	49064314	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:49064314A>G	ENST00000326739.4	-	7	664	c.625T>C	c.(625-627)Ttg>Ctg	p.L209L		NM_000884.2	NP_000875.2	P12268	IMDH2_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 2	209	CBS 2.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	ACAATGGGCAACTTTCCTGTG	0.512000													29	197					0	0	1	0	0
LOC645166	645166	broad.mit.edu	37	1	148933289	148933289	+	RNA	SNP	A	A	G	rs9729175	by1000genomes	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:148933289A>G	ENST00000539543.1	+	0	176					NR_027355.2																						TGCTGCCCGCAGGATATTGTG	0.562000													5	16					0	0	1	0	0
BTN2A2	10385	broad.mit.edu	37	6	26388264	26388264	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:26388264G>A	ENST00000356709.4	+	4	577	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K	BTN2A2_ENST00000469230.1_Missense_Mutation_p.E156K|BTN2A2_ENST00000416795.2_Missense_Mutation_p.E156K|BTN2A2_ENST00000482536.1_Intron|BTN2A2_ENST00000352867.2_Missense_Mutation_p.E40K|BTN2A2_ENST00000432533.2_Intron	NM_001197240.1|NM_006995.4	NP_001184169.1|NP_008926.2	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2	156	Ig-like C2-type.				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane				breast(2)|endometrium(3)|large_intestine(5)|lung(13)	23						GCCCCTCATTGAAATCAAGGC	0.572000													10	39					0	0	1	0	0
UCHL3	7347	broad.mit.edu	37	13	76141429	76141429	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:76141429G>A	ENST00000377595.3	+	5	437	c.407G>A	c.(406-408)aGa>aAa	p.R136K	RP11-29G8.3_ENST00000563635.1_RNA	NM_001270952.1|NM_006002.4	NP_001257881.1|NP_005993.1	P15374	UCHL3_HUMAN	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)	136					ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity			kidney(1)|large_intestine(2)|lung(3)|skin(1)	7				GBM - Glioblastoma multiforme(99;0.0125)		GAACGAGCCAGATACCTGGAG	0.403000													16	41					0	0	1	0	0
RDM1	201299	broad.mit.edu	37	17	34257132	34257132	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:34257132C>G	ENST00000394529.3	-	1	641	c.155G>C	c.(154-156)aGa>aCa	p.R52T	RDM1_ENST00000419453.2_Missense_Mutation_p.R52T|RDM1_ENST00000394527.1_Missense_Mutation_p.R52T|RDM1_ENST00000394528.3_Missense_Mutation_p.R75T|RDM1_ENST00000431884.2_Missense_Mutation_p.R75T|RDM1_ENST00000293273.6_Missense_Mutation_p.R75T|RDM1_ENST00000591402.1_Missense_Mutation_p.R52T|RDM1_ENST00000425909.3_Missense_Mutation_p.R75T|RDM1_ENST00000430160.2_Missense_Mutation_p.R52T	NM_001163130.1	NP_001156602.1	Q8NG50	RDM1_HUMAN	RAD52 motif 1	75	Necessary for nuclear localization and for nucleolar accumulation in response to heat shock.|RRM.				DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			breast(1)|kidney(3)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)	9		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTTTTGGGCTCTGTGGGCAGC	0.493000								Other identified genes with known or suspected DNA repair function					69	109					0	0	1	0	0
C12orf29	91298	broad.mit.edu	37	12	88442152	88442152	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:88442152G>A	ENST00000356891.3	+	7	1134	c.931G>A	c.(931-933)Gat>Aat	p.D311N		NM_001009894.2	NP_001009894.2	Q8N999	CL029_HUMAN	chromosome 12 open reading frame 29	311										large_intestine(3)|lung(1)|ovary(1)	5						TTTAAAAATAGATAATCAGAA	0.234000													5	39					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12320823	12320823	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:12320823G>A	ENST00000358136.3	+	11	1314	c.1184G>A	c.(1183-1185)cGa>cAa	p.R395Q	VPS13D_ENST00000356315.4_Missense_Mutation_p.R395Q	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	395					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GTTCATGATCGATTTCACAAA	0.418000													8	58					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183095341	183095341	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:183095341A>T	ENST00000258341.4	+	16	3145	c.2888A>T	c.(2887-2889)cAg>cTg	p.Q963L	LAMC1_ENST00000466964.1_3'UTR	NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	963	Laminin EGF-like 10.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATCACTGGTCAGCACTGTGAG	0.552000													19	99					0	0	1	0	0
SLC2A7	155184	broad.mit.edu	37	1	9063427	9063427	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:9063427C>T	ENST00000400906.1	-	12	1470	c.1471G>A	c.(1471-1473)Gag>Aag	p.E491K		NM_207420.2	NP_997303.2	Q6PXP3	GTR7_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 7	491						integral to membrane|plasma membrane	sugar transmembrane transporter activity			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|lung(4)|prostate(2)|skin(2)	24	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		TCTTTCTCCTCTGGAAGCTTC	0.493000													11	73					0	0	1	0	0
NUPL2	11097	broad.mit.edu	37	7	23224756	23224756	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:23224756C>T	ENST00000258742.5	+	2	448	c.189C>T	c.(187-189)ttC>ttT	p.F63F	AC005082.1_ENST00000366347.4_Intron|NUPL2_ENST00000410002.3_Silent_p.F63F|NUPL2_ENST00000487595.1_3'UTR	NM_007342.2	NP_031368.1	O15504	NUPL2_HUMAN	nucleoporin like 2	63					carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CATCCAGTTTCTCCAAATCCA	0.383000													19	42					0	0	1	0	0
C15orf40	123207	broad.mit.edu	37	15	83674372	83674372	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:83674372T>C	ENST00000304177.5	-	4	472	c.358A>G	c.(358-360)Aaa>Gaa	p.K120E	C15orf40_ENST00000513601.2_Missense_Mutation_p.K147E|C15orf40_ENST00000538348.2_Intron|C15orf40_ENST00000451195.3_Intron|RP11-382A20.5_ENST00000566841.1_RNA|C15orf40_ENST00000565712.1_Missense_Mutation_p.K62E	NM_001160114.1|NM_144597.2	NP_001153586.1|NP_653198.2	Q8WUR7	CO040_HUMAN	chromosome 15 open reading frame 40	120										large_intestine(3)|lung(2)|skin(1)	6						GCTTCCTTTTTTAATTTCTCC	0.463000													50	162					0	0	1	0	0
PCNXL4	64430	broad.mit.edu	37	14	60581897	60581897	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:60581897T>C	ENST00000406854.1	+	4	1629	c.1075T>C	c.(1075-1077)Tac>Cac	p.Y359H	PCNXL4_ENST00000317623.4_Missense_Mutation_p.Y125H|PCNXL4_ENST00000404681.2_Missense_Mutation_p.Y359H|PCNXL4_ENST00000406949.1_Missense_Mutation_p.Y125H					pecanex-like 4 (Drosophila)																		ATGCCTTTTCTACATCATTAT	0.388000													18	77					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34647309	34647309	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:34647309G>A	ENST00000537011.1	+	7	1832	c.1450G>A	c.(1450-1452)Gag>Aag	p.E484K	NUTM1_ENST00000333756.4_Missense_Mutation_p.E456K|NUTM1_ENST00000438749.3_Missense_Mutation_p.E474K	NM_001284292.1	NP_001271221.1			NUT midline carcinoma, family member 1																		TGAGGAGCTAGAGCAAGAAGA	0.463000													8	57					0	0	1	0	0
FHIT	2272	broad.mit.edu	37	3	59999833	59999833	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:59999833A>G	ENST00000468189.1	-	6	519	c.149T>C	c.(148-150)cTg>cCg	p.L50P	FHIT_ENST00000466788.1_Intron|FHIT_ENST00000492590.1_Missense_Mutation_p.L50P|FHIT_ENST00000476844.1_Missense_Mutation_p.L50P|FHIT_ENST00000341848.4_Missense_Mutation_p.L50P			P49789	FHIT_HUMAN	fragile histidine triad	50	HIT.				nucleotide metabolic process		bis(5'-adenosyl)-triphosphatase activity|protein binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)	12		all_cancers(2;2.37e-314)|all_epithelial(2;5.17e-286)|Colorectal(2;1.24e-68)|all_lung(2;1.31e-45)|Lung NSC(2;1.79e-44)|all_hematologic(2;1.59e-23)|Renal(2;1.03e-13)|Breast(2;1.06e-10)|Esophageal squamous(2;6.31e-09)|Melanoma(2;1.83e-07)|Acute lymphoblastic leukemia(2;5.46e-05)|all_neural(2;0.00118)|Medulloblastoma(2;0.00263)|Hepatocellular(2;0.0245)|Ovarian(2;0.0408)		UCEC - Uterine corpus endometrioid carcinoma (45;0.0887)|Epithelial(1;9.28e-70)|all cancers(1;3.07e-60)|Colorectal(1;2.33e-53)|STAD - Stomach adenocarcinoma(1;7.22e-48)|COAD - Colon adenocarcinoma(3;1.05e-44)|READ - Rectum adenocarcinoma(3;2.41e-08)|KIRC - Kidney renal clear cell carcinoma(10;0.000109)|Kidney(10;0.000125)|Lung(1;0.000161)|LUSC - Lung squamous cell carcinoma(1;0.000742)|OV - Ovarian serous cystadenocarcinoma(275;0.00372)|BRCA - Breast invasive adenocarcinoma(55;0.00448)		ATCAGGACGCAGGTCATGGAA	0.542000			T	HMGA2	pleomorphic salivary gland adenoma				Renal Cell Cancer associated with constitutional translocation of chromosome 3				5	55					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69719873	69719873	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:69719873C>T	ENST00000194900.4	+	18	2556	c.2215C>T	c.(2215-2217)Cag>Tag	p.Q739*	DLG3_ENST00000542398.1_Nonsense_Mutation_p.Q256*|DLG3_ENST00000374360.3_Nonsense_Mutation_p.Q707*|DLG3_ENST00000374355.3_Nonsense_Mutation_p.Q402*|DLG3_ENST00000461646.1_3'UTR			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	707	Guanylate kinase-like.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					GACCAGCATCCAGTCAGTGCG	0.498000													8	12					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	30999044	30999044	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:30999044G>A	ENST00000298139.5	+	25	3315	c.3066G>A	c.(3064-3066)ctG>ctA	p.L1022L		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	1022					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CCCGTCAGCTGATCACTGAGG	0.448000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				19	87					0	0	1	0	0
MED30	90390	broad.mit.edu	37	8	118533247	118533247	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:118533247C>T	ENST00000297347.3	+	1	296	c.132C>T	c.(130-132)atC>atT	p.I44I	MED30_ENST00000522839.1_Silent_p.I44I	NM_080651.2	NP_542382.1	Q96HR3	MED30_HUMAN	mediator complex subunit 30	44					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			kidney(1)|lung(3)|prostate(3)	7	all_cancers(13;3.41e-25)|Lung NSC(37;3.02e-05)|Ovarian(258;0.00163)		STAD - Stomach adenocarcinoma(47;0.0266)			TGCAGGACATCGTGTACCGCA	0.692000													5	31					0	0	1	0	0
CHAF1B	8208	broad.mit.edu	37	21	37775105	37775105	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:37775105G>A	ENST00000314103.5	+	8	864	c.713G>A	c.(712-714)cGt>cAt	p.R238H		NM_005441.2	NP_005432.1	Q13112	CAF1B_HUMAN	chromatin assembly factor 1, subunit B (p60)						cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(2)	20						TCTTTCTTCCGTAGACTGAGT	0.438000													38	299					0	0	1	0	0
SFMBT2	57713	broad.mit.edu	37	10	7230678	7230678	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:7230678G>A	ENST00000361972.4	-	16	1806	c.1716C>T	c.(1714-1716)atC>atT	p.I572I	SFMBT2_ENST00000397167.1_Silent_p.I572I	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	572					regulation of transcription, DNA-dependent	nucleus				NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						AGGCTGCGTTGATTATCATGC	0.433000													23	102					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125025760	125025760	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:125025760C>T	ENST00000522917.1	+	15	2117	c.1911C>T	c.(1909-1911)atC>atT	p.I637I	FER1L6-AS1_ENST00000518567.1_RNA|FER1L6_ENST00000399018.1_Silent_p.I637I	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	637						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GTGACTTCATCAGTCGGAGCA	0.453000													7	63					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12300420	12300420	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:12300420G>A	ENST00000261349.4	-	15	3353	c.3277C>T	c.(3277-3279)Cgg>Tgg	p.R1093W	LRP6_ENST00000543091.1_Missense_Mutation_p.R1093W	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1093	Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				AGGACCTCCCGTTCTGTCCCA	0.438000													11	174					0	0	1	0	0
CYB5R1	51706	broad.mit.edu	37	1	202934595	202934595	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:202934595C>G	ENST00000367249.4	-	5	453	c.379G>C	c.(379-381)Gag>Cag	p.E127Q		NM_016243.2	NP_057327.2	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1	127	FAD-binding FR-type.				sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity	p.E127Q(1)		breast(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(75;0.141)			TTCCCTCCCTCAGGAAATTTG	0.488000													13	76					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179466260	179466260	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:179466260G>A	ENST00000589042.1	-	287	55688	c.55464C>T	c.(55462-55464)gtC>gtT	p.V18488V	TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Silent_p.V9615V|TTN_ENST00000591111.1_Silent_p.V16847V|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Silent_p.V15920V|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.V9548V|TTN_ENST00000460472.2_Silent_p.V9423V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16847	Ig-like 106.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATATCACTGACTTTCAGAT	0.393000													26	125					0	0	1	0	0
TUBB6	84617	broad.mit.edu	37	18	12308769	12308769	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:12308769C>T	ENST00000317702.5	+	2	375	c.141C>T	c.(139-141)atC>atT	p.I47I	TUBB6_ENST00000590967.1_Silent_p.I47I|TUBB6_ENST00000586653.1_Silent_p.I47I|TUBB6_ENST00000592683.1_Silent_p.I47I|TUBB6_ENST00000591909.1_Silent_p.I47I|TUBB6_ENST00000591208.1_Silent_p.I47I			Q9BUF5	TBB6_HUMAN	tubulin, beta 6 class V	47					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)	14				READ - Rectum adenocarcinoma(1;0.0649)		TGGAGAGAATCAACGTCTACT	0.667000													5	42					0	0	1	0	0
LRP8	7804	broad.mit.edu	37	1	53724059	53724059	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:53724059G>A	ENST00000306052.6	-	14	2242	c.2141C>T	c.(2140-2142)tCt>tTt	p.S714F	LRP8_ENST00000371454.2_Missense_Mutation_p.S714F|LRP8_ENST00000347547.2_Missense_Mutation_p.S544F|LRP8_ENST00000354412.3_Missense_Mutation_p.S585F|LRP8_ENST00000465675.1_Missense_Mutation_p.S267F|LRP8_ENST00000460214.1_5'UTR	NM_004631.4	NP_004622.2	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	714					cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(1)	21						GTACTTGGGAGAGTGGCTGGA	0.567000													14	73					0	0	1	0	0
ZYG11B	79699	broad.mit.edu	37	1	53237265	53237265	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:53237265G>C	ENST00000294353.6	+	3	915	c.770G>C	c.(769-771)cGc>cCc	p.R257P	ZYG11B_ENST00000443756.2_Missense_Mutation_p.R257P|ZYG11B_ENST00000545132.1_Missense_Mutation_p.R257P	NM_024646.2	NP_078922.1	Q9C0D3	ZY11B_HUMAN	zyg-11 family member B, cell cycle regulator	257							protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	30						ATAGCTCTTCGCTTACTAGAA	0.393000													6	64					0	0	1	0	0
STK36	27148	broad.mit.edu	37	2	219562316	219562316	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:219562316G>A	ENST00000295709.3	+	24	3171	c.2892G>A	c.(2890-2892)ctG>ctA	p.L964L	STK36_ENST00000392106.2_Silent_p.L943L|STK36_ENST00000440309.1_Silent_p.L964L|STK36_ENST00000392105.3_Silent_p.L943L	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	964					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CCAGCTTCCTGAATCAACTGC	0.532000													11	39					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30676032	30676032	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:30676032T>C	ENST00000376406.3	-	8	2971	c.2324A>G	c.(2323-2325)tAt>tGt	p.Y775C	MDC1_ENST00000376405.2_Intron|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	775				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						GCAAGGTCCATAGGCCTCAAG	0.557000								Other conserved DNA damage response genes					8	77					0	0	1	0	0
TLK2	11011	broad.mit.edu	37	17	60689850	60689850	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:60689850C>T	ENST00000582809.1	+	23	2433	c.1730C>T	c.(1729-1731)tCa>tTa	p.S577L	TLK2_ENST00000346027.5_Missense_Mutation_p.S726L|TLK2_ENST00000542523.1_Missense_Mutation_p.S694L|TLK2_ENST00000343388.7_Missense_Mutation_p.S694L|TLK2_ENST00000326270.9_Missense_Mutation_p.S748L			Q86UE8	TLK2_HUMAN	tousled-like kinase 2	748	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						ATCCGAAAGTCAGTCTCTACA	0.517000													15	59					0	0	1	0	0
LIX1	167410	broad.mit.edu	37	5	96443095	96443095	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:96443095T>C	ENST00000274382.4	-	3	651	c.356A>G	c.(355-357)gAa>gGa	p.E119G	CTD-2215E18.1_ENST00000509481.1_Intron	NM_153234.4	NP_694966.3	Q8N485	LIX1_HUMAN	Lix1 homolog (chicken)	119										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(2)|ovary(1)	10		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		CTGAACACTTTCCATAATGAA	0.527000													14	33					0	0	1	0	0
WLS	79971	broad.mit.edu	37	1	68624830	68624830	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:68624830G>A	ENST00000262348.4	-	3	733	c.480C>T	c.(478-480)ctC>ctT	p.L160L	WLS_ENST00000370976.3_Silent_p.L69L|WLS_ENST00000354777.2_Silent_p.L158L|GNG12-AS1_ENST00000413628.1_RNA|GNG12-AS1_ENST00000420587.1_RNA|WLS_ENST00000540432.1_Silent_p.L160L	NM_024911.6	NP_079187.3	Q5T9L3	WLS_HUMAN	wntless Wnt ligand secretion mediator	160	Interacts with Wnt proteins (By similarity).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(4)|prostate(3)|urinary_tract(1)	20						AGGTGCATTTGAGTTTCCGTG	0.453000													19	81					0	0	1	0	0
FAM3D	131177	broad.mit.edu	37	3	58631328	58631328	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:58631328G>A	ENST00000358781.2	-	5	481	c.171C>T	c.(169-171)ctC>ctT	p.L57L		NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	57					negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		AGGGCTTGATGAGGCCACACT	0.557000													9	38					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8100479	8100479	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:8100479C>T	ENST00000379328.3	+	3	1021	c.453C>T	c.(451-453)ttC>ttT	p.F151F	GATA3_ENST00000346208.3_Silent_p.F151F|GATA3_ENST00000461472.1_3'UTR	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	151					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						CGCACCTCTTCACCTTCCCGC	0.726000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						5	52					0	0	1	0	0
TTC23L	153657	broad.mit.edu	37	5	34867123	34867123	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:34867123G>A	ENST00000505624.1	+	7	892	c.789G>A	c.(787-789)caG>caA	p.Q263Q	TTC23L_ENST00000514080.1_3'UTR	NM_144725.3	NP_653326.3	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	263							binding	p.Q263Q(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(9)|prostate(2)|stomach(1)|urinary_tract(1)	22						AAGCTGCTCAGATAGAGCAGC	0.547000													3	18					0	0	1	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182908473	182908473	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:182908473T>G	ENST00000367547.3	-	5	1150	c.914A>C	c.(913-915)aAa>aCa	p.K305T	SHCBP1L_ENST00000423786.1_Missense_Mutation_p.K186T|SHCBP1L_ENST00000488956.1_5'UTR	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	377								p.K305T(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						CTCCAAAGTTTTTTTAAAACG	0.343000													14	88					0	0	1	0	0
SNAI2	6591	broad.mit.edu	37	8	49831524	49831524	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:49831524G>A	ENST00000396822.1	-	4	1006	c.649C>T	c.(649-651)Cac>Tac	p.H217Y	SNAI2_ENST00000020945.1_Missense_Mutation_p.H217Y			O43623	SNAI2_HUMAN	snail family zinc finger 2	217					canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)	18		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				CTGTTGCAGTGAGGGCAAGAA	0.423000													4	39					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72350363	72350363	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:72350363C>T	ENST00000389916.4	+	18	2509	c.2371C>T	c.(2371-2373)Cgg>Tgg	p.R791W		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	791					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						GCGGCGCTCGCGGGCCCTGGG	0.682000													10	56					0	0	1	0	0
C11orf35	256329	broad.mit.edu	37	11	556066	556066	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:556066G>C	ENST00000329451.3	-	11	1369	c.1307C>G	c.(1306-1308)tCg>tGg	p.S436W		NM_173573.2	NP_775844.2	Q8IXW0	CK035_HUMAN	chromosome 11 open reading frame 35	436										NS(1)|breast(1)|central_nervous_system(1)|lung(4)|pancreas(1)	8		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTCCCGGCTCGAGGACGCGCG	0.796000													3	13					0	0	1	0	0
APLP2	334	broad.mit.edu	37	11	129992404	129992404	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:129992404C>T	ENST00000263574.5	+	6	990	c.918C>T	c.(916-918)gtC>gtT	p.V306V	APLP2_ENST00000338167.5_Silent_p.V306V|APLP2_ENST00000345598.5_Intron|APLP2_ENST00000278756.7_Silent_p.V316V|APLP2_ENST00000543137.1_Silent_p.V213V|APLP2_ENST00000539648.1_Silent_p.V150V|APLP2_ENST00000528499.1_Silent_p.V306V	NM_001642.2	NP_001633.1	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	306	BPTI/Kunitz inhibitor.				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		CTCATGATGTCAAAGGTAACC	0.443000													6	59					0	0	1	0	0
PTPN1	5770	broad.mit.edu	37	20	49194981	49194981	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:49194981C>T	ENST00000371621.3	+	6	691	c.517C>T	c.(517-519)Cat>Tat	p.H173Y	PTPN1_ENST00000541713.1_Missense_Mutation_p.H100Y	NM_001278618.1|NM_002827.2	NP_001265547.1|NP_002818.1	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type 1	173	Tyrosine-protein phosphatase.				blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(2)	16		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	AGAGATCTTACATTTCCACTA	0.413000													26	189					0	0	1	0	0
DYNLRB1	83658	broad.mit.edu	37	20	33114081	33114081	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:33114081G>A	ENST00000300469.9	+	2	27	c.12G>A	c.(10-12)gtG>gtA	p.V4V	DYNLRB1_ENST00000480759.1_3'UTR|DYNLRB1_ENST00000357156.2_Silent_p.V4V|DYNLRB1_ENST00000417166.2_Silent_p.V4V|DYNLRB1_ENST00000374846.3_Silent_p.V56V			Q9NP97	DLRB1_HUMAN	dynein, light chain, roadblock-type 1	4					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity			endometrium(1)|large_intestine(1)|lung(1)	3						AGGCAGAGGTGGAGGAGACAC	0.552000													4	21					0	0	1	0	0
ITGA3	3675	broad.mit.edu	37	17	48166512	48166512	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:48166512G>T	ENST00000007722.7	+	25	3084	c.3084G>T	c.(3082-3084)atG>atT	p.M1028I	ITGA3_ENST00000320031.8_3'UTR			P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	1027					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						ATCAGATCATGCCCAAGTACC	0.567000													28	208					7.41945e-09	7.69666e-09	1	1	0
DMPK	1760	broad.mit.edu	37	19	46282709	46282709	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:46282709C>T	ENST00000600757.1	-	2	1041	c.354G>A	c.(352-354)ctG>ctA	p.L118L	DMPK_ENST00000354227.5_Silent_p.L108L|DMPK_ENST00000343373.4_Silent_p.L118L|DMPK_ENST00000447742.2_Silent_p.L108L|AC011530.4_ENST00000593999.1_3'UTR|DMPK_ENST00000291270.4_Silent_p.L108L|DMPK_ENST00000458663.2_Silent_p.L108L			Q09013	DMPK_HUMAN	dystrophia myotonica-protein kinase	118	Protein kinase.				regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(5)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)|urinary_tract(2)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		CGCCCCTCTTCAGCATGTCCC	0.622000													34	97					0	0	1	0	0
MPI	4351	broad.mit.edu	37	15	75189912	75189912	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:75189912G>A	ENST00000352410.4	+	8	1180	c.1113G>A	c.(1111-1113)ctG>ctA	p.L371L	MPI_ENST00000566377.1_3'UTR|MPI_ENST00000563786.1_Silent_p.L351L|MPI_ENST00000535694.1_Silent_p.L321L|MPI_ENST00000323744.6_Silent_p.L310L			P34949	MPI_HUMAN	mannose phosphate isomerase	371					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						GCATCCTCCTGATGGTACAGG	0.547000													5	59					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71206727	71206727	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:71206727C>T	ENST00000553414.1	-	6	1119	c.804G>A	c.(802-804)caG>caA	p.Q268Q	MAP3K9_ENST00000554752.2_Intron|MAP3K9_ENST00000555993.2_Intron|MAP3K9_ENST00000554146.1_Intron|MAP3K9_ENST00000381250.4_Intron			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	563	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CCTGTGTGTTCTGGCCCCAGC	0.562000													7	30					0	0	1	0	0
SRBD1	55133	broad.mit.edu	37	2	45620192	45620192	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:45620192C>G	ENST00000263736.4	-	20	2652	c.2590G>C	c.(2590-2592)Gaa>Caa	p.E864Q	SRBD1_ENST00000535761.1_Missense_Mutation_p.E383Q|SRBD1_ENST00000490133.1_5'UTR	NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	864					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			CCTTCCTTTTCAAGGAATGAA	0.393000													13	76					0	0	1	0	0
BARX2	8538	broad.mit.edu	37	11	129246048	129246048	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:129246048G>A	ENST00000281437.4	+	1	214	c.118G>A	c.(118-120)Gag>Aag	p.E40K		NM_003658.4	NP_003649.2	Q9UMQ3	BARX2_HUMAN	BARX homeobox 2	40										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	20	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		CGATTACTTTGAGAAACTTTC	0.592000											OREG0021508	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	133					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22211109	22211109	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:22211109G>A	ENST00000374695.3	-	13	1645	c.1566C>T	c.(1564-1566)ttC>ttT	p.F522F		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	522	Laminin EGF-like 1; first part.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGCCAAAGCAGAAGCAGGGCA	0.687000													7	33					0	0	1	0	0
TRMT61B	55006	broad.mit.edu	37	2	29092987	29092987	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:29092987C>G	ENST00000306108.5	-	1	180	c.157G>C	c.(157-159)Gag>Cag	p.E53Q		NM_017910.3	NP_060380.3	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B (S. cerevisiae)	53							tRNA (adenine-N1-)-methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)	13						GCCTCGTGCTCTCTTTCTCCA	0.582000													8	47					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230662472	230662472	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:230662472A>G	ENST00000283943.5	-	23	3511	c.3333T>C	c.(3331-3333)gaT>gaC	p.D1111D	TRIP12_ENST00000389045.3_Silent_p.D841D|TRIP12_ENST00000543084.1_3'UTR|TRIP12_ENST00000389044.4_Silent_p.D1159D	NM_001284214.1|NM_004238.1	NP_001271143.1|NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1111					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		GGTTGCTTCCATCCATATTCT	0.398000													14	55					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34091670	34091670	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:34091670G>A	ENST00000397527.1	+	30	6193	c.5473G>A	c.(5473-5475)Gaa>Aaa	p.E1825K	CEP250_ENST00000342580.4_Missense_Mutation_p.E1769K	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1825	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TCTGCAGCAAGAACAGCAGCA	0.597000													9	24					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87033134	87033134	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:87033134C>G	ENST00000370563.3	+	7	1024	c.982C>G	c.(982-984)Caa>Gaa	p.Q328E	CLCA4_ENST00000263723.5_Missense_Mutation_p.Q41E	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	328	VWFA.					apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TCGAATGAATCAAGCAGCAAA	0.363000													12	32					0	0	1	0	0
ZFP69	339559	broad.mit.edu	37	1	40960597	40960597	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:40960597G>A	ENST00000372706.1	+	6	1453	c.447G>A	c.(445-447)ttG>ttA	p.L149L	ZFP69_ENST00000372705.3_Silent_p.L149L|RP11-656D10.3_ENST00000450713.1_RNA					ZFP69 zinc finger protein																		TTTCAGACTTGAAGAGTAAAA	0.338000													83	38					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18690843	18690843	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:18690843C>T	ENST00000399799.2	-	1	969	c.29G>A	c.(28-30)cGa>cAa	p.R10Q		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1						actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					TTTTTCAAATCGAGTCTCAAA	0.498000													6	95					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53605598	53605598	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:53605598A>G	ENST00000425354.2	-	10	1714	c.1227T>C	c.(1225-1227)ccT>ccC	p.P409P	RARG_ENST00000338561.5_Silent_p.P398P|RARG_ENST00000543762.1_5'UTR|RARG_ENST00000327550.3_Silent_p.P337P|RARG_ENST00000394426.1_Silent_p.P409P|RARG_ENST00000543726.1_Silent_p.P387P	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	409	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GGATTAAGGGAGGCATCGGGC	0.552000													7	28					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187516891	187516891	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:187516891C>T	ENST00000441802.2	-	26	13299	c.13090G>A	c.(13090-13092)Gaa>Aaa	p.E4364K		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4364					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GACTGCACTTCAGACAGGCTT	0.512000										HNSCC(5;0.00058)			8	48					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98744789	98744789	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:98744789C>G	ENST00000477737.1	+	6	994	c.790C>G	c.(790-792)Cca>Gca	p.P264A	VWA3B_ENST00000435344.1_Missense_Mutation_p.P264A|VWA3B_ENST00000451075.2_Missense_Mutation_p.P114A	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	264										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GATCCCGTGTCCAGTCTACAC	0.493000													10	71					0	0	1	0	0
ELMO3	79767	broad.mit.edu	37	16	67236305	67236305	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:67236305G>C	ENST00000393997.2	+	14	1483	c.1426G>C	c.(1426-1428)Gag>Cag	p.E476Q	ELMO3_ENST00000360833.1_Missense_Mutation_p.E459Q|ELMO3_ENST00000477898.1_Missense_Mutation_p.E310Q	NM_024712.3	NP_078988.2	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	423	ELMO.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding			cervix(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		TCCAGGCTCTGAGACAGCCCA	0.607000													31	66					0	0	1	0	0
ZC3H6	376940	broad.mit.edu	37	2	113088888	113088888	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:113088888C>G	ENST00000409871.1	+	12	2794	c.2393C>G	c.(2392-2394)tCt>tGt	p.S798C	ZC3H6_ENST00000343936.4_Missense_Mutation_p.S798C	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	798							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						CACATAGGCTCTTCTGTTGGT	0.448000													16	69					0	0	1	0	0
ZNF430	80264	broad.mit.edu	37	19	21239707	21239707	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:21239707G>A	ENST00000261560.5	+	5	774	c.593G>A	c.(592-594)aGa>aAa	p.R198K		NM_001172671.1|NM_025189.3	NP_001166142.1|NP_079465.3	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						CAAAAGATAAGACATACTGGA	0.279000													5	41					0	0	1	0	0
SLC2A6	11182	broad.mit.edu	37	9	136341396	136341396	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:136341396G>A	ENST00000371899.4	-	4	602	c.525C>T	c.(523-525)ctC>ctT	p.L175L	SLC2A6_ENST00000371897.4_Silent_p.L175L|SLC2A6_ENST00000485978.1_5'UTR	NM_017585.3	NP_060055.2	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 6	175						integral to membrane|plasma membrane	D-glucose transmembrane transporter activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(3)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		ACACTGCCATGAGCTGGGGTG	0.632000													4	23					0	0	1	0	0
SREK1IP1	285672	broad.mit.edu	37	5	64037000	64037000	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:64037000T>C	ENST00000513458.4	-	3	256	c.89A>G	c.(88-90)aAt>aGt	p.N30S	SREK1IP1_ENST00000506252.1_5'UTR	NM_173829.3	NP_776190.1	Q8N9Q2	SR1IP_HUMAN	SREK1-interacting protein 1	30					mRNA processing|RNA splicing		nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|ovary(1)	6						TCGGAGAAAATTGCGGCATTC	0.353000													25	13					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36271181	36271181	+	Silent	SNP	C	C	T	rs139345874		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:36271181C>T	ENST00000007510.4	+	7	714	c.570C>T	c.(568-570)gcC>gcT	p.A190A	ARHGAP33_ENST00000378944.5_Silent_p.A54A|ARHGAP33_ENST00000314737.5_Silent_p.A190A			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	190	SH3.				cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CAGTGGCGGCCGCCCATGTGA	0.602000													8	31					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133664099	133664099	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:133664099G>A	ENST00000310926.4	-	10	1574	c.1301C>T	c.(1300-1302)tCa>tTa	p.S434L	SLCO2A1_ENST00000493729.1_Missense_Mutation_p.S358L	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	434					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						TATAGAACTTGATGTGCTGCC	0.527000													32	111					0	0	1	0	0
LIPA	3988	broad.mit.edu	37	10	91005539	91005539	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:91005539G>A	ENST00000336233.5	-	3	445	c.123C>T	c.(121-123)atC>atT	p.I41I	LIPA_ENST00000371837.1_Intron|LIPA_ENST00000456827.1_Silent_p.I41I			P38571	LICH_HUMAN	lipase A, lysosomal acid, cholesterol esterase	41					lipid catabolic process	lysosome	lipase activity|sterol esterase activity			endometrium(1)|large_intestine(2)|lung(3)	6		Colorectal(252;0.0162)		GBM - Glioblastoma multiforme(2;0.00406)		CCCAGTAAGAGATAATTTCAC	0.413000													10	43					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171077357	171077357	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:171077357G>C	ENST00000367755.4	+	5	733	c.622G>C	c.(622-624)Gaa>Caa	p.E208Q	FMO3_ENST00000392085.2_Missense_Mutation_p.E208Q|FMO3_ENST00000542847.1_Missense_Mutation_p.E188Q|FMO3_ENST00000538429.1_Missense_Mutation_p.E145Q	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	208					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCGCACAGCAGAACAGGTACT	0.502000													9	52					0	0	1	0	0
POC1A	25886	broad.mit.edu	37	3	52172281	52172281	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:52172281C>T	ENST00000394970.2	-	7	1034	c.717G>A	c.(715-717)ccG>ccA	p.P239P	POC1A_ENST00000296484.2_Silent_p.P239P|POC1A_ENST00000474012.1_Silent_p.P201P	NM_001161580.1	NP_001155052.1	Q8NBT0	POC1A_HUMAN	POC1 centriolar protein A	239						centriole|microtubule basal body				endometrium(1)|large_intestine(4)|liver(1)|lung(4)|prostate(3)|skin(1)	14						AGTTTCCCGACGGGTGGAAAG	0.597000													6	17					0	0	1	0	0
INO80B	83444	broad.mit.edu	37	2	74682246	74682246	+	Translation_Start_Site	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:74682246G>C	ENST00000233331.7	+	1	97	c.3G>C	c.(1-3)atG>atC	p.M1I	INO80B_ENST00000469849.1_3'UTR|INO80B_ENST00000409917.1_Start_Codon_SNP_p.M1I	NM_031288.3	NP_112578.2	Q9C086	IN80B_HUMAN	INO80 complex subunit B	1					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|nucleolus	metal ion binding|protein binding			endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	13						AGGACCTCATGAGTAAGCTGT	0.552000													10	82					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28771794	28771794	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:28771794C>T	ENST00000422425.2	+	15	1081	c.1037C>T	c.(1036-1038)tCt>tTt	p.S346F	PLB1_ENST00000329020.6_Missense_Mutation_p.S23F|PLB1_ENST00000327757.5_Missense_Mutation_p.S335F	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	335	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					AAGTGTCCCTCTCAGGTAGGA	0.542000													6	40					0	0	1	0	0
FAHD1	81889	broad.mit.edu	37	16	1877386	1877386	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:1877386C>T	ENST00000382666.4	+	1	419	c.156C>T	c.(154-156)taC>taT	p.Y52Y	FAHD1_ENST00000427358.2_Silent_p.Y52Y|FAHD1_ENST00000382668.4_Silent_p.Y52Y	NM_001018104.2	NP_001018114.1	Q6P587	FAHD1_HUMAN	fumarylacetoacetate hydrolase domain containing 1	52						mitochondrion	hydrolase activity|metal ion binding|protein binding			NS(1)|large_intestine(1)|liver(1)|ovary(2)|urinary_tract(1)	6						CCACGGCCTACGCGCCCGAGG	0.682000													4	38					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14804406	14804406	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:14804406C>A	ENST00000261170.3	-	15	1781	c.1645G>T	c.(1645-1647)Ggc>Tgc	p.G549C		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	549	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity	p.G549C(1)		breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						TTCACTGTGCCGTAGAACTTG	0.403000													5	70					0.000602214	0.000612158	1	1	0
MSLNL	401827	broad.mit.edu	37	16	830696	830696	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:830696G>A	ENST00000293892.3	-	3	304	c.305C>T	c.(304-306)aCc>aTc	p.T102I	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	0					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						GCACGGGTAGGTTACAGTGTG	0.587000													4	111					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25266672	25266672	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:25266672A>G	ENST00000218548.6	+	9	1525	c.1192A>G	c.(1192-1194)Aag>Gag	p.K398E	ATP12A_ENST00000381946.3_Missense_Mutation_p.K392E	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	392					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CTGCTCGGACAAGACTGGGAC	0.547000													7	42					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20819441	20819441	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:20819441G>A	ENST00000328879.4	-	4	972	c.816C>T	c.(814-816)agC>agT	p.S272S	KLHL22_ENST00000440659.2_Silent_p.S129S	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	272					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			ACATGAGGGCGCTGGCCACTG	0.637000													6	98					0	0	1	0	0
RTP2	344892	broad.mit.edu	37	3	187416547	187416547	+	Silent	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:187416547G>T	ENST00000358241.1	-	2	845	c.417C>A	c.(415-417)atC>atA	p.I139I		NM_001004312.2	NP_001004312.2	Q5QGT7	RTP2_HUMAN	receptor (chemosensory) transporter protein 2	139					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			large_intestine(3)|lung(14)|skin(1)	18	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		TGGCCACGTGGATGCGGTACT	0.647000													8	23					1.26484e-09	1.31596e-09	1	1	0
TENM2	57451	broad.mit.edu	37	5	167653205	167653205	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:167653205G>A	ENST00000519204.1	+	23	4976	c.4858G>A	c.(4858-4860)Gat>Aat	p.D1620N	TENM2_ENST00000518659.1_Missense_Mutation_p.D1741N|TENM2_ENST00000403607.2_Missense_Mutation_p.D1565N|TENM2_ENST00000520394.1_Missense_Mutation_p.D1502N|TENM2_ENST00000545108.1_Missense_Mutation_p.D1740N					teneurin transmembrane protein 2																		CTCCAACCGTGATGATGACGT	0.542000													6	11					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78513626	78513626	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:78513626C>T	ENST00000397909.2	+	15	3823	c.3650C>T	c.(3649-3651)tCc>tTc	p.S1217F	NAV3_ENST00000228327.6_Missense_Mutation_p.S1217F|NAV3_ENST00000266692.7_Missense_Mutation_p.S1217F|NAV3_ENST00000536525.2_Missense_Mutation_p.S1217F			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1217	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TTGTCAGGTTCCCCCAAATCC	0.522000										HNSCC(70;0.22)			5	52					0	0	1	0	0
UXS1	80146	broad.mit.edu	37	2	106729128	106729128	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:106729128G>A	ENST00000283148.7	-	10	950	c.853C>T	c.(853-855)Cag>Tag	p.Q285*	UXS1_ENST00000409501.3_Nonsense_Mutation_p.Q280*|UXS1_ENST00000428048.2_Nonsense_Mutation_p.Q124*|UXS1_ENST00000540130.1_Nonsense_Mutation_p.Q223*|UXS1_ENST00000409032.1_Nonsense_Mutation_p.Q112*	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	280					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						TGGAGCGCCTGCAGGATGAAG	0.577000													8	35					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44672550	44672550	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:44672550G>C	ENST00000243964.3	+	11	1470	c.1372G>C	c.(1372-1374)Gag>Cag	p.E458Q	SLC12A5_ENST00000454036.2_Missense_Mutation_p.E481Q	NM_020708.4	NP_065759.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	481					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GGCCTGCATTGAGGGGGTCGT	0.562000													13	109					0	0	1	0	0
RAD51	5888	broad.mit.edu	37	15	41011012	41011012	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:41011012G>A	ENST00000267868.3	+	6	713	c.445G>A	c.(445-447)Gac>Aac	p.D149N	RAD51_ENST00000557850.1_Intron|RAD51_ENST00000532743.1_Missense_Mutation_p.D150N|RAD51_ENST00000382643.3_Missense_Mutation_p.D150N|RAD51_ENST00000423169.2_Missense_Mutation_p.D149N	NM_002875.4	NP_002866.2	Q06609	RAD51_HUMAN	RAD51 recombinase	149					DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)|ovary(1)	9		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		GCTTCCCATTGACCGGGGTGG	0.458000								Homologous recombination					5	26					0	0	1	0	0
OR6N2	81442	broad.mit.edu	37	1	158746965	158746965	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:158746965A>G	ENST00000339258.1	-	1	460	c.461T>C	c.(460-462)cTg>cCg	p.L154P		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					AATGGGACACAGGAAGCCACA	0.488000													5	66					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49430970	49430970	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:49430970C>A	ENST00000301067.7	-	34	10168	c.10169G>T	c.(10168-10170)tGc>tTc	p.C3390F	KMT2D_ENST00000549743.1_5'UTR	NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CGGCTTCATGCACATGGAAGG	0.557000													15	28					1.37285e-15	1.44104e-15	1	1	0
SDK1	221935	broad.mit.edu	37	7	4150355	4150355	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:4150355G>A	ENST00000404826.2	+	23	3524	c.3385G>A	c.(3385-3387)Gat>Aat	p.D1129N	SDK1_ENST00000389531.3_Missense_Mutation_p.D1129N	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1129	Fibronectin type-III 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GAATGAGCCTGATGCCCAGAT	0.557000													6	14					0	0	1	0	0
GSTM3	2947	broad.mit.edu	37	1	110282867	110282867	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:110282867G>A	ENST00000540225.1	-	2	353	c.43C>T	c.(43-45)Cgt>Tgt	p.R15C	GSTM3_ENST00000256594.3_Missense_Mutation_p.R15C|GSTM3_ENST00000361066.2_Missense_Mutation_p.R15C|GSTM3_ENST00000488824.1_5'UTR|RP4-735C1.4_ENST00000431955.1_RNA			P21266	GSTM3_HUMAN	glutathione S-transferase mu 3 (brain)	15	GST N-terminal.				establishment of blood-nerve barrier|glutathione metabolic process|response to estrogen stimulus	cytoplasm	glutathione transferase activity|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|skin(1)	9		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Colorectal(144;0.0339)|Lung(183;0.0426)|all cancers(265;0.113)|Epithelial(280;0.125)|COAD - Colon adenocarcinoma(174;0.134)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	CTCACCCCACGAATATCCCAG	0.607000													4	19					0	0	1	0	0
CEL	1056	broad.mit.edu	37	9	135946414	135946414	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:135946414G>A	ENST00000372080.4	+	11	1550	c.1534G>A	c.(1534-1536)Gaa>Aaa	p.E512K	CEL_ENST00000351304.7_Missense_Mutation_p.E443K	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	509					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		CACACACTGGGAACCCTACAC	0.612000													4	44					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86210372	86210372	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:86210372T>G	ENST00000370571.2	-	57	5015	c.4649A>C	c.(4648-4650)aAc>aCc	p.N1550T	COL24A1_ENST00000436319.1_Missense_Mutation_p.N1529T	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1550	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTGTTCACAGTTAAGTAAATC	0.358000													14	84					0	0	1	0	0
SRSF7	6432	broad.mit.edu	37	2	38975255	38975255	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:38975255C>G	ENST00000313117.6	-	5	743	c.506G>C	c.(505-507)cGt>cCt	p.R169P	SRSF7_ENST00000409276.1_Missense_Mutation_p.R169P|SRSF7_ENST00000446327.2_Missense_Mutation_p.R169P	NM_001031684.2|NM_001195446.1	NP_001026854.1|NP_001182375.1	Q16629	SRSF7_HUMAN	serine/arginine-rich splicing factor 7	169	6 X 8 AA repeats of R-R-S-R-S-X-S-X.|Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						TCTTGATCTACGAAGAGAGAT	0.373000													3	65					0	0	1	0	0
SLC17A5	26503	broad.mit.edu	37	6	74345107	74345107	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:74345107G>C	ENST00000355773.5	-	6	1085	c.817C>G	c.(817-819)Cag>Gag	p.Q273E	SLC17A5_ENST00000481996.1_5'UTR|SLC17A5_ENST00000393019.3_3'UTR	NM_012434.4	NP_036566.1	Q9NRA2	S17A5_HUMAN	solute carrier family 17 (acidic sugar transporter), member 5	273					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GTCCATACCTGATTTCTTAAT	0.289000													28	105					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152757197	152757197	+	Missense_Mutation	SNP	C	C	T	rs149918889		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:152757197C>T	ENST00000367255.5	-	33	4790	c.4189G>A	c.(4189-4191)Gag>Aag	p.E1397K	SYNE1_ENST00000341594.5_Missense_Mutation_p.E1463K|SYNE1_ENST00000413186.2_Missense_Mutation_p.E1397K|SYNE1_ENST00000265368.4_Missense_Mutation_p.E1397K|SYNE1_ENST00000367253.4_Missense_Mutation_p.E1397K|SYNE1_ENST00000367248.3_Missense_Mutation_p.E1387K|SYNE1_ENST00000423061.1_Missense_Mutation_p.E1404K|SYNE1_ENST00000448038.1_Missense_Mutation_p.E1404K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1397					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACAAGGTTCTCAGCCTGGACT	0.388000										HNSCC(10;0.0054)			5	74					0	0	1	0	0
TNFAIP6	7130	broad.mit.edu	37	2	152222618	152222618	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:152222618A>C	ENST00000243347.3	+	3	356	c.281A>C	c.(280-282)tAc>tCc	p.Y94S		NM_007115.3	NP_009046.2	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	94	Link.				cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.131)		AGAGTTGGATACCCCATTGTG	0.448000													6	101					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49394958	49394958	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:49394958C>T	ENST00000419783.1	-	2	796	c.475G>A	c.(475-477)Gat>Aat	p.D159N	GPX1_ENST00000419349.1_3'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	159					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CAGGCAACATCGTTGCGACAC	0.627000													15	47					0	0	1	0	0
MIXL1	83881	broad.mit.edu	37	1	226413461	226413461	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:226413461C>G	ENST00000366810.5	+	2	711	c.647C>G	c.(646-648)tCa>tGa	p.S216*	MIXL1_ENST00000542034.1_Nonsense_Mutation_p.S224*|MIXL1_ENST00000557734.1_3'UTR			Q9H2W2	MIXL1_HUMAN	Mix paired-like homeobox	216					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.109)		GACATTGGTTCAAAGCTGGAC	0.502000													17	113					0	0	1	0	0
GLG1	2734	broad.mit.edu	37	16	74506261	74506261	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:74506261G>A	ENST00000422840.2	-	14	2100	c.2101C>T	c.(2101-2103)Cag>Tag	p.Q701*	GLG1_ENST00000205061.5_Nonsense_Mutation_p.Q701*|GLG1_ENST00000447066.2_Nonsense_Mutation_p.Q690*	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1	701						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						CAGAAGTTCTGAATTATGGGC	0.423000													5	51					0	0	1	0	0
CLCN5	1184	broad.mit.edu	37	X	49851280	49851280	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:49851280C>G	ENST00000376088.3	+	11	1951	c.1310C>G	c.(1309-1311)aCt>aGt	p.T437S	CLCN5_ENST00000376108.3_Missense_Mutation_p.T367S|CLCN5_ENST00000376091.3_Missense_Mutation_p.T437S|CLCN5_ENST00000307367.2_Missense_Mutation_p.T367S	NM_001127898.1|NM_001127899.1	NP_001121370.1|NP_001121371.1	P51795	CLCN5_HUMAN	chloride channel, voltage-sensitive 5	367					excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)	30	Ovarian(276;0.236)					ACAGCCATCACTGCCATCCTG	0.507000													10	35					0	0	1	0	0
ZIK1	284307	broad.mit.edu	37	19	58101897	58101897	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:58101897G>A	ENST00000597850.1	+	4	933	c.718G>A	c.(718-720)Gag>Aag	p.E240K	ZIK1_ENST00000536878.2_Missense_Mutation_p.E227K|ZIK1_ENST00000599456.1_Missense_Mutation_p.E185K|ZIK1_ENST00000307468.4_3'UTR	NM_001010879.2	NP_001010879.2	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein 1	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	34		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAAGCTTTATGAGTGTAGCAA	0.458000													5	41					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49957408	49957408	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:49957408C>T	ENST00000376056.2	-	5	2079	c.1929G>A	c.(1927-1929)gaG>gaA	p.E643E	AKAP4_ENST00000376064.3_Silent_p.E643E|AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000376058.2_Silent_p.E269E|AKAP4_ENST00000358526.2_Silent_p.E652E			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	652					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					AACACTTGTTCTCACCTTCGC	0.453000													25	37					0	0	1	0	0
C22orf42	150297	broad.mit.edu	37	22	32555138	32555138	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:32555138G>A	ENST00000382097.3	-	1	137	c.65C>T	c.(64-66)cCa>cTa	p.P22L		NM_001010859.1	NP_001010859.1	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	22										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	24						TCCCACATCTGGCCTGCAGCA	0.562000													11	41					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95720144	95720144	+	RNA	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:95720144T>C	ENST00000480546.1	-	0	1153					NR_002319.2																						CCCTTTACTATTCCGGGCAGG	0.498000													11	61					0	0	1	0	0
TFDP2	7029	broad.mit.edu	37	3	141688976	141688976	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:141688976T>C	ENST00000499676.2	-	9	1162	c.491A>G	c.(490-492)aAg>aGg	p.K164R	TFDP2_ENST00000495310.1_Missense_Mutation_p.K127R|TFDP2_ENST00000317104.7_Missense_Mutation_p.K148R|TFDP2_ENST00000489671.1_Missense_Mutation_p.K224R|TFDP2_ENST00000467072.1_Missense_Mutation_p.K164R|TFDP2_ENST00000310282.6_Missense_Mutation_p.K164R|TFDP2_ENST00000479040.1_Missense_Mutation_p.K163R|TFDP2_ENST00000486111.1_Missense_Mutation_p.K164R|TFDP2_ENST00000477292.1_Missense_Mutation_p.K88R|TFDP2_ENST00000397991.4_Missense_Mutation_p.K196R	NM_001178139.1	NP_001171610.1	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization partner 2)	224					cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)|upper_aerodigestive_tract(2)	3						CCGCCTCTGCTTCTCTATCTT	0.393000													4	94					0	0	1	0	0
ZNF781	163115	broad.mit.edu	37	19	38160216	38160216	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:38160216G>A	ENST00000358582.4	-	4	1582	c.834C>T	c.(832-834)ttC>ttT	p.F278F	ZNF781_ENST00000590008.1_Silent_p.F278F|ZFP30_ENST00000586732.1_Intron	NM_152605.3	NP_689818.2	Q8N8C0	ZN781_HUMAN	zinc finger protein 781	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24						TCACCAGTGTGAATTCTCTGG	0.378000													16	51					0	0	1	0	0
SCAF11	9169	broad.mit.edu	37	12	46355560	46355560	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:46355560G>A	ENST00000369367.3	-	3	375	c.142C>T	c.(142-144)Cta>Tta	p.L48L	SCAF11_ENST00000395454.2_Silent_p.L48L|SCAF11_ENST00000395453.2_Silent_p.L48L|SCAF11_ENST00000419565.2_Silent_p.L48L	NM_004719.2	NP_004710.2	Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	48					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TTTTCTAATAGACAATTAAGA	0.368000													10	48					0	0	1	0	0
KAZALD1	81621	broad.mit.edu	37	10	102822540	102822540	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:102822540C>T	ENST00000370200.5	+	2	517	c.191C>T	c.(190-192)cCg>cTg	p.P64L		NM_030929.4	NP_112191.2	Q96I82	KAZD1_HUMAN	Kazal-type serine peptidase inhibitor domain 1	64	Cys-rich.|IGFBP N-terminal.				cell differentiation|multicellular organismal development|ossification|regulation of cell growth		insulin-like growth factor binding			endometrium(1)|ovary(1)|prostate(2)	4				Epithelial(162;6.21e-09)|all cancers(201;3.14e-07)		TGCGCCGCGCCGCGGGGCTGC	0.741000													9	16					0	0	1	0	0
KRT33A	3883	broad.mit.edu	37	17	39502449	39502449	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:39502449G>C	ENST00000007735.3	-	7	1181	c.1137C>G	c.(1135-1137)gaC>gaG	p.D379E		NM_004138.3	NP_004129.2	O76009	KT33A_HUMAN	keratin 33A	379	Tail.					intermediate filament	protein binding|structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	21		Breast(137;0.000496)				CAGTGGACTTGTCACATGCAT	0.522000													4	56					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66945206	66945206	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:66945206G>A	ENST00000299752.4	-	14	1996	c.1803C>T	c.(1801-1803)gtC>gtT	p.V601V	CDH16_ENST00000565796.1_Silent_p.V601V|CDH16_ENST00000568632.1_Silent_p.V504V|CDH16_ENST00000570262.1_Silent_p.V521V|CDH16_ENST00000394055.3_Silent_p.V601V	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	601	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CTGAGTCATTGACTAGGGAGA	0.582000													11	22					0	0	1	0	0
RCBTB1	55213	broad.mit.edu	37	13	50125590	50125590	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:50125590G>A	ENST00000378302.2	-	8	986	c.726C>T	c.(724-726)taC>taT	p.Y242Y	RCBTB1_ENST00000258646.3_Silent_p.Y242Y|RCBTB1_ENST00000546015.1_Silent_p.Y242Y	NM_018191.3	NP_060661.3	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	242					cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|urinary_tract(1)	16		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		GAGTATGTGCGTAACCGCAGA	0.468000													8	42					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82833907	82833907	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:82833907A>G	ENST00000265077.3	+	8	5650	c.5085A>G	c.(5083-5085)caA>caG	p.Q1695Q	VCAN_ENST00000342785.4_Intron|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000343200.5_Silent_p.Q708Q|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000512590.2_Intron|VCAN_ENST00000502527.2_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1695	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTTCTGAACAACCTTCTGCAA	0.408000													8	68					0	0	1	0	0
WASF2	10163	broad.mit.edu	37	1	27736447	27736447	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:27736447C>T	ENST00000430629.2	-	8	1293	c.1078G>A	c.(1078-1080)Gat>Aat	p.D360N	WASF2_ENST00000536657.1_Intron	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	360					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		GCAGCAAAATCAGGGTGAGGT	0.622000													4	37					0	0	1	0	0
C16orf11	146325	broad.mit.edu	37	16	613462	613462	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:613462G>A	ENST00000409413.3	+	2	447	c.168G>A	c.(166-168)atG>atA	p.M56I		NM_145270.2	NP_660313.1	P0CG20	CP011_HUMAN	chromosome 16 open reading frame 11	56										central_nervous_system(1)|endometrium(1)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10						ACAACCACATGAAGTACAGCC	0.622000													3	41					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414024	105414024	+	Silent	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:105414024G>C	ENST00000333244.5	-	7	7883	c.7764C>G	c.(7762-7764)gtC>gtG	p.V2588V	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2588						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGGGGCCCTTGACATCTAGCT	0.627000													49	195					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22211893	22211893	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:22211893G>C	ENST00000374695.3	-	10	1209	c.1130C>G	c.(1129-1131)tCt>tGt	p.S377C		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	377	LDL-receptor class A 4.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CATGTTGGTAGAGACGCATCG	0.622000													6	43					0	0	1	0	0
SAA4	6291	broad.mit.edu	37	11	18254081	18254081	+	Splice_Site	SNP	C	C	T	rs35302306		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:18254081C>T	ENST00000278222.4	-	3	272		c.e3-1		SAA2-SAA4_ENST00000524555.1_RNA	NM_006512.3	NP_006503.2			serum amyloid A4, constitutive											haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|skin(1)|stomach(1)	13						TCCCCAACCCCTGGAAAGAAA	0.403000													20	106					0	0	1	0	0
ENO1	2023	broad.mit.edu	37	1	8932038	8932038	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:8932038G>A	ENST00000234590.4	-	3	212	c.93C>T	c.(91-93)ttC>ttT	p.F31F		NM_001428.3	NP_001419.1	P06733	ENOA_HUMAN	enolase 1, (alpha)	31	Epitope recognized by CAR and healthy patient antibodies.				gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CAGCAGCTCTGAAGAGACCTG	0.493000											OREG0013069	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	70					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133218261	133218261	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:133218261C>T	ENST00000320574.5	-	39	5393	c.5350G>A	c.(5350-5352)Gag>Aag	p.E1784K	POLE_ENST00000535270.1_Missense_Mutation_p.E1757K	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1784					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		AGGGCTGTCTCATCGTAGCTG	0.562000								DNA polymerases (catalytic subunits)					6	29					0	0	1	0	0
ULK3	25989	broad.mit.edu	37	15	75132945	75132945	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:75132945C>T	ENST00000440863.2	-	5	598	c.507G>A	c.(505-507)gaG>gaA	p.E169E	ULK3_ENST00000569437.1_Silent_p.E169E|ULK3_ENST00000568667.1_Silent_p.E180E	NM_001099436.1	NP_001092906	Q6PHR2	ULK3_HUMAN	unc-51 like kinase 3	169	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(2)	2						GCACGTGCTTCTCATCCCACG	0.602000													8	14					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15718959	15718959	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:15718959G>A	ENST00000396368.3	-	9	2231	c.2025C>T	c.(2023-2025)gtC>gtT	p.V675V	KIAA0430_ENST00000548025.1_Silent_p.V672V|KIAA0430_ENST00000602337.1_Silent_p.V672V|KIAA0430_ENST00000344181.3_Intron|KIAA0430_ENST00000551742.1_Silent_p.V674V|KIAA0430_ENST00000540441.2_Silent_p.V532V	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	674						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						GAGTGGGTACGACCAGCCTCA	0.512000													10	72					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31305404	31305404	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:31305404G>A	ENST00000265071.2	+	7	1388	c.1123G>A	c.(1123-1125)Gag>Aag	p.E375K	CDH6_ENST00000514738.1_Missense_Mutation_p.E320K	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	375	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AATTGTGGTGGAGGATGTAGA	0.458000													16	64					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152276585	152276585	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:152276585C>T	ENST00000368799.1	-	3	10812	c.10777G>A	c.(10777-10779)Gag>Aag	p.E3593K	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3593	Ser-rich.		E -> D (in dbSNP:rs12083389).		keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGAGCTCTCTGCAGAGTGC	0.547000									Ichthyosis				99	387					0	0	1	0	0
TRIB2	28951	broad.mit.edu	37	2	12858570	12858570	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:12858570C>T	ENST00000155926.4	+	1	1556	c.137C>T	c.(136-138)cCg>cTg	p.P46L	TRIB2_ENST00000381465.2_Intron|TRIB2_ENST00000405331.3_Missense_Mutation_p.P46L	NM_021643.3	NP_067675.1	Q92519	TRIB2_HUMAN	tribbles pseudokinase 2	46					negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(5)|prostate(1)|skin(1)|stomach(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTCGGCTCCCCGAGCCCGCCC	0.547000											OREG0014450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	71					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135139639	135139639	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:135139639C>T	ENST00000372169.2	-	27	8290	c.8108G>A	c.(8107-8109)aGa>aAa	p.R2703K	SETX_ENST00000477049.1_5'UTR|SETX_ENST00000393220.1_Missense_Mutation_p.R2641K|SETX_ENST00000224140.5_Missense_Mutation_p.R2674K			Q7Z333	SETX_HUMAN	senataxin	2674					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TAAAAGCTTTCTTTTCTTGGA	0.507000													26	115					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27746181	27746181	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:27746181A>T	ENST00000264717.2	+	19	1816	c.1753A>T	c.(1753-1755)Act>Tct	p.T585S	GCKR_ENST00000424318.2_Missense_Mutation_p.T395S	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	585					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					GTGCTCGATCACTGAGGCTCA	0.602000													3	19					0	0	1	0	0
HACL1	26061	broad.mit.edu	37	3	15624391	15624391	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:15624391G>A	ENST00000321169.5	-	8	1027	c.660C>T	c.(658-660)atC>atT	p.I220I	HACL1_ENST00000457447.2_Silent_p.I194I|HACL1_ENST00000435217.2_Intron|HACL1_ENST00000451445.2_Silent_p.I138I|HACL1_ENST00000456194.2_Silent_p.I193I	NM_012260.2	NP_036392.2	Q9UJ83	HACL1_HUMAN	2-hydroxyacyl-CoA lyase 1	220					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding			NS(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	16						TACCTTTCCCGATGATAAGAA	0.403000													31	52					0	0	1	0	0
AQP5	362	broad.mit.edu	37	12	50357877	50357877	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:50357877C>G	ENST00000293599.6	+	3	679	c.531C>G	c.(529-531)atC>atG	p.I177M		NM_001651.2	NP_001642.1	P55064	AQP5_HUMAN	aquaporin 5	177					carbon dioxide transport|excretion|odontogenesis|pancreatic juice secretion	apical plasma membrane|integral to plasma membrane	protein binding|water channel activity			large_intestine(1)|lung(3)	4						CTATCCAGATCTACTTCACTG	0.582000													7	47					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39438678	39438678	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:39438678G>A	ENST00000280481.7	+	16	8134	c.7918G>A	c.(7918-7920)Gtt>Att	p.V2640I		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2640					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ATGGGAGTTCGTTAGCTACTA	0.473000													4	71					0	0	1	0	0
GRHPR	9380	broad.mit.edu	37	9	37429803	37429803	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:37429803G>C	ENST00000607784.1	+	6	573	c.568G>C	c.(568-570)Gag>Cag	p.E190Q	GRHPR_ENST00000318158.6_Missense_Mutation_p.E190Q			Q9UBQ7	GRHPR_HUMAN	glyoxylate reductase/hydroxypyruvate reductase	190					cellular nitrogen compound metabolic process|excretion|glyoxylate metabolic process	peroxisomal matrix	glycerate dehydrogenase activity|glyoxylate reductase (NADP) activity|hydroxypyruvate reductase activity|NAD binding|protein binding	p.E190Q(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12				GBM - Glioblastoma multiforme(29;0.00687)		GCCCAGGCCTGAGGAAGCAGC	0.537000													6	53					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54895545	54895545	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:54895545G>A	ENST00000356805.4	+	36	7215	c.6934G>A	c.(6934-6936)Gag>Aag	p.E2312K		NM_003128.2	NP_003119.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	2312					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			TGATAAACACGAGGTGTCTGC	0.592000													7	42					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182853889	182853889	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:182853889G>A	ENST00000367549.3	+	27	3512	c.3402G>A	c.(3400-3402)atG>atA	p.M1134I	DHX9_ENST00000485081.1_3'UTR	NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	1134					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						TGCTGAACATGATCCGTCAGA	0.483000													51	66					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70928396	70928396	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:70928396G>A	ENST00000334414.6	-	31	6284	c.6240C>T	c.(6238-6240)caC>caT	p.H2080H	PTPRB_ENST00000451516.2_Silent_p.H1772H|PTPRB_ENST00000550857.1_Silent_p.H1772H|PTPRB_ENST00000538708.1_Silent_p.H1772H|PTPRB_ENST00000261266.5_Silent_p.H1862H|RP11-588H23.3_ENST00000549460.1_RNA|RP11-588H23.3_ENST00000548687.1_RNA|RP11-588H23.3_ENST00000551438.1_RNA|PTPRB_ENST00000550358.1_Silent_p.H1992H|RP11-588H23.3_ENST00000546836.1_RNA|RP11-588H23.3_ENST00000547656.1_RNA	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1862					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TATAGTGAAAGTGGCGGATGA	0.502000													73	13					0	0	1	0	0
TP53TG5	27296	broad.mit.edu	37	20	44004026	44004026	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:44004026C>G	ENST00000372726.3	-	4	577	c.421G>C	c.(421-423)Gag>Cag	p.E141Q	SYS1_ENST00000426004.1_3'UTR|SYS1-DBNDD2_ENST00000452133.1_Intron|SYS1-DBNDD2_ENST00000475242.1_Intron|TP53TG5_ENST00000537995.1_Missense_Mutation_p.E125Q	NM_014477.2	NP_055292.1	Q9Y2B4	T53G5_HUMAN	TP53 target 5	141					intracellular signal transduction|negative regulation of cell growth	cytoplasm|nucleus				central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)	12						GACGTTTTCTCCTTGTTCCTC	0.498000													54	176					0	0	1	0	0
RGAG4	340526	broad.mit.edu	37	X	71350616	71350616	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:71350616G>A	ENST00000545866.1	-	1	1142	c.775C>T	c.(775-777)Cag>Tag	p.Q259*	RGAG4_ENST00000609883.1_Nonsense_Mutation_p.Q259*|NHSL2_ENST00000540800.1_Intron	NM_001024455.3	NP_001019626.1	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	259										cervix(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|skin(1)	24	Renal(35;0.156)					GCCAGGAACTGAAAAGCATCT	0.527000													10	43					0	0	1	0	0
PDXDC1	23042	broad.mit.edu	37	16	15100393	15100393	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:15100393C>G	ENST00000396410.4	+	6	629	c.532C>G	c.(532-534)Ctt>Gtt	p.L178V	PDXDC1_ENST00000325823.7_Missense_Mutation_p.L163V|PDXDC1_ENST00000569715.1_Missense_Mutation_p.L151V|PDXDC1_ENST00000450288.2_Missense_Mutation_p.L150V|PDXDC1_ENST00000447912.2_Missense_Mutation_p.L87V|PDXDC1_ENST00000455313.2_Missense_Mutation_p.L178V|PDXDC1_ENST00000563679.1_Missense_Mutation_p.L196V|PDXDC1_ENST00000535621.2_Missense_Mutation_p.L178V	NM_015027.2	NP_055842.2	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain containing 1	178				L -> F (in Ref. 3; AAZ14099).	carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(10)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	TGTCATATATCTTAGTGCTGC	0.393000													11	89					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67316218	67316218	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:67316218G>A	ENST00000360461.5	+	8	3754	c.1219G>A	c.(1219-1221)Gag>Aag	p.E407K	PLEKHG4_ENST00000379344.3_Missense_Mutation_p.E407K|PLEKHG4_ENST00000450733.1_Missense_Mutation_p.E326K|PLEKHG4_ENST00000427155.2_Missense_Mutation_p.E407K	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	407					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		GCTGAAGCAAGAGGTCCCAGA	0.612000													4	24					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31847922	31847922	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:31847922C>T	ENST00000395728.3	-	27	3742	c.3743G>A	c.(3742-3744)cGc>cAc	p.R1248H	EHMT2_ENST00000375537.4_Missense_Mutation_p.R1191H|EHMT2_ENST00000375530.4_Missense_Mutation_p.R1157H|EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375528.4_Missense_Mutation_p.R1214H			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1191					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						TGGGTCCAGGCGGGCCAGACG	0.602000													6	28					0	0	1	0	0
PDE3B	5140	broad.mit.edu	37	11	14856593	14856593	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:14856593C>T	ENST00000282096.4	+	11	2625	c.2272C>T	c.(2272-2274)Cct>Tct	p.P758S	PDE3B_ENST00000455098.2_Missense_Mutation_p.P707S	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	758	Catalytic (By similarity).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						ACGGCCAGTTCCTGGCTTACA	0.383000													6	28					0	0	1	0	0
FAM8A1	51439	broad.mit.edu	37	6	17600920	17600920	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:17600920G>A	ENST00000259963.3	+	1	335	c.280G>A	c.(280-282)Gag>Aag	p.E94K		NM_016255.2	NP_057339.1	Q9UBU6	FA8A1_HUMAN	family with sequence similarity 8, member A1	94						integral to membrane		p.E94K(1)|p.E94Q(1)		endometrium(1)|large_intestine(2)|lung(3)	6	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.143)	all cancers(50;0.176)|Epithelial(50;0.204)			GGCGGGCTGCGAGGCGCCCGA	0.731000													13	11					0	0	1	0	0
ZNF704	619279	broad.mit.edu	37	8	81599565	81599565	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:81599565C>T	ENST00000327835.3	-	4	685	c.454G>A	c.(454-456)Gac>Aac	p.D152N	ZNF704_ENST00000520336.1_5'UTR	NM_001033723.2	NP_001028895.1	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	152						intracellular	zinc ion binding			lung(9)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			TTGAAGCTGTCAGCCGAGAGC	0.692000											OREG0018841	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	33					0	0	1	0	0
S100P	6286	broad.mit.edu	37	4	6698763	6698763	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:6698763C>T	ENST00000296370.3	+	2	1146	c.282C>T	c.(280-282)ctC>ctT	p.L94L	S100P_ENST00000513778.1_3'UTR	NM_005980.2	NP_005971.1	P25815	S100P_HUMAN	S100 calcium binding protein P	94					endothelial cell migration	cytoplasm|nucleus	calcium ion binding|calcium-dependent protein binding|magnesium ion binding			prostate(1)	1		Myeloproliferative disorder(84;0.0255)		Colorectal(103;0.011)	Cromoglicate(DB01003)	AGGCAGGACTCAAATGATGCC	0.517000													25	125					0	0	1	0	0
ZNF750	79755	broad.mit.edu	37	17	80788041	80788041	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:80788041G>A	ENST00000269394.3	-	3	2982	c.2149C>T	c.(2149-2151)Cga>Tga	p.R717*	ZNF750_ENST00000572562.1_Nonsense_Mutation_p.R318*|TBCD_ENST00000397466.2_Intron|TBCD_ENST00000539345.2_Intron|TBCD_ENST00000355528.4_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	717						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCCCTCCTTCGTAGTGTGAAC	0.557000													7	77					0	0	1	0	0
CHDH	55349	broad.mit.edu	37	3	53855796	53855796	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:53855796G>A	ENST00000315251.6	-	5	1300	c.863C>T	c.(862-864)gCc>gTc	p.A288V		NM_018397.4	NP_060867.2	Q8NE62	CHDH_HUMAN	choline dehydrogenase						alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	CTCCTTGCTGGCATAAGCCTG	0.552000													5	38					0	0	1	0	0
NDUFA10	4705	broad.mit.edu	37	2	240961647	240961647	+	Silent	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:240961647T>C	ENST00000252711.2	-	2	286	c.186A>G	c.(184-186)gtA>gtG	p.V62V	NDUFA10_ENST00000407129.3_Silent_p.V62V|NDUFA10_ENST00000404554.1_Silent_p.V62V|NDUFA10_ENST00000307300.4_Silent_p.V62V	NM_004544.3	NP_004535.1	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	62					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)	16		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	TATTGCCATCTACAGTTATCA	0.393000													4	62					0	0	1	0	0
SPG20	23111	broad.mit.edu	37	13	36900832	36900832	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:36900832T>C	ENST00000451493.1	-	5	1385	c.1168A>G	c.(1168-1170)Aaa>Gaa	p.K390E	SPG20_ENST00000494062.2_Missense_Mutation_p.K390E|SPG20_ENST00000495510.1_5'UTR|SPG20_ENST00000355182.4_Missense_Mutation_p.K390E|SPG20_ENST00000438666.2_Missense_Mutation_p.K390E	NM_001142295.1	NP_001135767.1	Q8N0X7	SPG20_HUMAN	spastic paraplegia 20 (Troyer syndrome)	390					cell death	cytoplasm	ubiquitin protein ligase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	27		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		GAAGTATCTTTAGCCTAAACA	0.343000													4	29					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118624072	118624072	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:118624072C>T	ENST00000336338.5	-	14	2021	c.1956G>A	c.(1954-1956)atG>atA	p.M652I		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	652						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TATTCATTTTCATGACATATT	0.408000													8	103					0	0	1	0	0
RPRML	388394	broad.mit.edu	37	17	45056119	45056119	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:45056119G>A	ENST00000322329.3	-	1	495	c.255C>T	c.(253-255)ttC>ttT	p.F85F	RP11-156P1.2_ENST00000571841.1_Intron|GOSR2_ENST00000439730.2_Intron|LRRC37A17P_ENST00000570478.1_RNA	NM_203400.4	NP_981945.1	Q8N4K4	RPRML_HUMAN	reprimo-like	85						integral to membrane				lung(1)	1						AGCCCAGGAAGAAGACGCCGA	0.677000													3	8					0	0	1	0	0
KBTBD2	25948	broad.mit.edu	37	7	32914648	32914648	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:32914648C>T	ENST00000304056.4	-	3	991	c.292G>A	c.(292-294)Gac>Aac	p.D98N	KBTBD2_ENST00000485611.1_5'UTR|AVL9_ENST00000404479.1_Intron	NM_015483.2	NP_056298.2	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	98	BTB.									endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|urinary_tract(1)	17			GBM - Glioblastoma multiforme(11;0.0499)			ACAGTGCTGTCATTCATTGCC	0.413000													36	90					0	0	1	0	0
CIAO1	9391	broad.mit.edu	37	2	96936853	96936853	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:96936853C>T	ENST00000488633.1	+	7	1003	c.784C>T	c.(784-786)Cag>Tag	p.Q262*		NM_004804.2	NP_004795.1	O76071	CIAO1_HUMAN	cytosolic iron-sulfur protein assembly 1	262					chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding			endometrium(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	5						TTCCAGGTGTCAGCTGACAGG	0.557000													8	83					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	169952504	169952504	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:169952504G>A	ENST00000367765.1	-	13	2794	c.1293C>T	c.(1291-1293)ctC>ctT	p.L431L	KIFAP3_ENST00000538366.1_Silent_p.L393L|KIFAP3_ENST00000540905.1_Silent_p.L173L|KIFAP3_ENST00000361580.2_Silent_p.L471L|KIFAP3_ENST00000367767.1_Silent_p.L427L	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	471					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCCTCTTCATGAGCATCTTCA	0.333000													29	59					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34535466	34535466	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:34535466C>G	ENST00000374012.3	+	18	3085	c.2956C>G	c.(2956-2958)Ctt>Gtt	p.L986V	PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	986					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					GCTGGCCAGGCTTCCGCAGCT	0.577000													5	37					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	8995751	8995751	+	Silent	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:8995751T>C	ENST00000299698.7	+	12	1450	c.1270T>C	c.(1270-1272)Tta>Cta	p.L424L		NM_001282424.1|NM_144670.4	NP_001269353.1|NP_653271	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	268						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						AATGGAAGACTTAGTATATAA	0.463000													4	51					0	0	1	0	0
BDNF	627	broad.mit.edu	37	11	27680121	27680121	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:27680121C>T	ENST00000314915.6	-	2	658	c.15G>A	c.(13-15)gtG>gtA	p.V5V	BDNF_ENST00000530861.1_5'UTR|BDNF_ENST00000584049.1_5'UTR|BDNF_ENST00000533131.1_5'UTR|BDNF_ENST00000395978.3_5'UTR|BDNF-AS_ENST00000500662.2_RNA|BDNF_ENST00000438929.1_Silent_p.V79V|BDNF_ENST00000532997.1_5'UTR|BDNF_ENST00000525950.1_5'UTR|BDNF_ENST00000525528.1_5'UTR|BDNF_ENST00000418212.1_5'UTR|BDNF-AS_ENST00000501176.2_RNA|BDNF-AS_ENST00000530313.1_RNA|BDNF_ENST00000395981.3_5'UTR|BDNF_ENST00000439476.2_5'UTR|BDNF-AS_ENST00000499008.3_RNA|BDNF_ENST00000533246.1_5'UTR|BDNF_ENST00000395983.3_5'UTR|BDNF_ENST00000395986.2_Silent_p.V12V|BDNF-AS_ENST00000502161.2_RNA|BDNF-AS_ENST00000499568.2_RNA|BDNF_ENST00000395980.2_5'UTR|BDNF_ENST00000356660.4_5'UTR|BDNF-AS_ENST00000530686.1_RNA|BDNF_ENST00000420794.1_5'UTR	NM_170731.4	NP_733927.1	P23560	BDNF_HUMAN	brain-derived neurotrophic factor	0						extracellular region	growth factor activity			breast(1)|large_intestine(3)|lung(2)	6						TCACTCTTCTCACCTGGTGGA	0.463000													9	54					0	0	1	0	0
LOXL4	84171	broad.mit.edu	37	10	100013525	100013525	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:100013525C>G	ENST00000260702.3	-	11	1770	c.1620G>C	c.(1618-1620)caG>caC	p.Q540H	RP11-34A14.3_ENST00000433374.1_RNA	NM_032211.6	NP_115587.6	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4	540	Lysyl-oxidase like.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(8)|ovary(4)|prostate(1)|skin(2)	26		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		CCTGCACTAGCTGGGCGTTCA	0.612000													6	25					0	0	1	0	0
RASA2	5922	broad.mit.edu	37	3	141327397	141327397	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:141327397G>A	ENST00000286364.3	+	21	2118	c.2083G>A	c.(2083-2085)Gaa>Aaa	p.E695K	RASA2_ENST00000452898.1_Missense_Mutation_p.E696K|RASA2_ENST00000509118.1_3'UTR			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	695	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						AGAAGCTAATGAATGGATAGA	0.408000													10	80					0	0	1	0	0
POLA2	23649	broad.mit.edu	37	11	65063393	65063393	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:65063393G>T	ENST00000265465.3	+	17	2110	c.1579G>T	c.(1579-1581)Gtt>Ttt	p.V527F	POLA2_ENST00000541089.1_Missense_Mutation_p.V319F|POLA2_ENST00000534785.1_Intron	NM_002689.2	NP_002680.2	Q14181	DPOA2_HUMAN	polymerase (DNA directed), alpha 2, accessory subunit	527					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding			endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	11					Dacarbazine(DB00851)	GTCGTTCTATGTTTACGCACA	0.507000													11	81					1.61879e-10	1.68669e-10	1	1	0
RPS20	6224	broad.mit.edu	37	8	56986287	56986287	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:56986287G>A	ENST00000519807.1	-	3	269	c.144C>T	c.(142-144)ctC>ctT	p.L48L	RPS20_ENST00000523936.1_Silent_p.L48L|RPS20_ENST00000520490.1_Intron|RPS20_ENST00000521262.1_Silent_p.L48L|RPS20_ENST00000518875.1_Silent_p.L48L|RPS20_ENST00000520627.1_5'UTR|RPS20_ENST00000524349.1_5'UTR|RPS20_ENST00000009589.3_Silent_p.L48L|RPS20_ENST00000519606.1_Intron	NM_001146227.1	NP_001139699.1	P60866	RS20_HUMAN	ribosomal protein S20	48					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome						all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)			CTTTCACTTTGAGATTCTTTT	0.408000													52	293					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8404245	8404245	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:8404245C>T	ENST00000360416.3	-	29	3781	c.3643G>A	c.(3643-3645)Gag>Aag	p.E1215K	MYH10_ENST00000269243.4_Missense_Mutation_p.E1184K|MYH10_ENST00000379980.4_Missense_Mutation_p.E1200K|MYH10_ENST00000396239.1_Missense_Mutation_p.E1205K	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	1184					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						GTTTCCTCCTCAAGAGCTTTC	0.448000													28	98					0	0	1	0	0
ATP5G3	518	broad.mit.edu	37	2	176043918	176043918	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:176043918G>A	ENST00000284727.4	-	4	3205	c.181C>T	c.(181-183)Cag>Tag	p.Q61*	ATP5G3_ENST00000392541.3_Nonsense_Mutation_p.Q61*|ATP5G3_ENST00000409194.1_Nonsense_Mutation_p.Q61*	NM_001002258.4|NM_001689.4	NP_001002258.1|NP_001680.1	P48201	AT5G3_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)	61					ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding|protein binding			large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.147)			GCACTGGTCTGAAACTCCCTT	0.463000													8	57					0	0	1	0	0
NAT9	26151	broad.mit.edu	37	17	72769080	72769080	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:72769080C>T	ENST00000357814.3	-	4	362	c.289G>A	c.(289-291)Gat>Aat	p.D97N	NAT9_ENST00000583476.1_Missense_Mutation_p.D97N|NAT9_ENST00000583757.1_Missense_Mutation_p.D96N|NAT9_ENST00000582870.1_Missense_Mutation_p.D101N|NAT9_ENST00000580301.1_Missense_Mutation_p.D96N|NAT9_ENST00000581136.1_Missense_Mutation_p.D97N|NAT9_ENST00000580216.1_5'UTR|NAT9_ENST00000578822.1_Missense_Mutation_p.D102N|NAT9_ENST00000582524.1_Missense_Mutation_p.D97N|NAT9_ENST00000580632.1_Missense_Mutation_p.D96N	NM_015654.3	NP_056469.2	Q9BTE0	NAT9_HUMAN	N-acetyltransferase 9 (GCN5-related, putative)	97	N-acetyltransferase.					protein complex	N-acetyltransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)	8						TCTTCTAGATCTGTGAGGAAG	0.567000													17	26					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56336935	56336935	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:56336935C>T	ENST00000370754.5	-	94	21986	c.21987G>A	c.(21985-21987)gtG>gtA	p.V7329V	DST_ENST00000312431.6_3'UTR|DST_ENST00000361203.3_Silent_p.V7040V|DST_ENST00000421834.2_Intron|DST_ENST00000446842.2_Silent_p.V6825V|DST_ENST00000370769.4_Silent_p.V7151V|DST_ENST00000370788.2_Silent_p.V4954V|DST_ENST00000244364.6_Silent_p.V4737V			Q03001	DYST_HUMAN	dystonin	7149	GAR.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GCCATTTGCTCACCAGTAAGT	0.453000													14	36					0	0	1	0	0
KRT17	3872	broad.mit.edu	37	17	39780589	39780589	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:39780589G>C	ENST00000311208.8	-	1	240	c.173C>G	c.(172-174)tCc>tGc	p.S58C	JUP_ENST00000540235.1_Intron	NM_000422.2	NP_000413.1	Q04695	K1C17_HUMAN	keratin 17	58	Head.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	12		Breast(137;0.000307)				GTAGCAGCTGGAGTAGCTGCT	0.667000													9	49					0	0	1	0	0
OBSL1	23363	broad.mit.edu	37	2	220431669	220431669	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:220431669C>T	ENST00000404537.1	-	5	2073	c.2017G>A	c.(2017-2019)Gag>Aag	p.E673K	OBSL1_ENST00000373873.4_Missense_Mutation_p.E673K|OBSL1_ENST00000603926.1_Missense_Mutation_p.E673K|OBSL1_ENST00000289656.3_Missense_Mutation_p.E260K|OBSL1_ENST00000265318.4_Missense_Mutation_p.E673K|OBSL1_ENST00000373876.1_Missense_Mutation_p.E673K	NM_015311.2	NP_056126.1	O75147	OBSL1_HUMAN	obscurin-like 1	673					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity						Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CCCTTCTGCTCTATACGGTAC	0.622000													7	26					0	0	1	0	0
DLX3	1747	broad.mit.edu	37	17	48072150	48072150	+	Silent	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:48072150G>C	ENST00000434704.2	-	1	438	c.213C>G	c.(211-213)ctC>ctG	p.L71L		NM_005220.2	NP_005211.1	O60479	DLX3_HUMAN	distal-less homeobox 3	71						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	12						CAAGCCCATTGAGATTGAATT	0.607000													8	48					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102483482	102483482	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:102483482G>A	ENST00000360184.4	+	39	8070	c.7906G>A	c.(7906-7908)Gat>Aat	p.D2636N		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2636	AAA 3 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						GAAGACTTTTGATCACTACTG	0.493000													22	87					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49670734	49670734	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:49670734G>T	ENST00000561648.1	-	4	2382	c.2329C>A	c.(2329-2331)Ccg>Acg	p.P777T	ZNF423_ENST00000262383.2_Missense_Mutation_p.P777T|ZNF423_ENST00000562520.1_Missense_Mutation_p.P717T|ZNF423_ENST00000563137.2_Missense_Mutation_p.P717T|ZNF423_ENST00000567169.1_Missense_Mutation_p.P660T|ZNF423_ENST00000562871.1_Missense_Mutation_p.P717T|ZNF423_ENST00000535559.1_Missense_Mutation_p.P660T	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	777					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				GCCTTGGCCGGGTTGCCCAGG	0.567000													4	32					0.00909568	0.00918651	1	1	0
ADCY10	55811	broad.mit.edu	37	1	167849836	167849836	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:167849836G>A	ENST00000367848.1	-	10	1253	c.756C>T	c.(754-756)ttC>ttT	p.F252F	ADCY10_ENST00000545172.1_Silent_p.F191F|ADCY10_ENST00000367851.4_Silent_p.F344F			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	344					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AGACACAGAGGAAAGAGCAGC	0.522000													10	42					0	0	1	0	0
GCSAM	257144	broad.mit.edu	37	3	111851950	111851950	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:111851950C>T	ENST00000308910.4	-	1	202	c.18G>A	c.(16-18)ctG>ctA	p.L6L	GCSAM_ENST00000484193.1_Silent_p.L6L	NM_001190259.1|NM_001190260.1|NM_152785.4	NP_001177188.1|NP_001177189.1|NP_689998.1			germinal center-associated, signaling and motility																		TGTTTTCTCTCAGCAGAGAAT	0.498000													5	73					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124036416	124036416	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:124036416G>A	ENST00000368994.2	+	3	383	c.132G>A	c.(130-132)ctG>ctA	p.L44L	BTBD16_ENST00000260723.4_Silent_p.L43L			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	43										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				GCAAGGCTCTGAGCATAGACT	0.562000													52	35					0	0	1	0	0
HMBOX1	79618	broad.mit.edu	37	8	28876350	28876350	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:28876350C>G	ENST00000397358.3	+	7	1475	c.771C>G	c.(769-771)gtC>gtG	p.V257V	HMBOX1_ENST00000558662.1_Silent_p.V257V|HMBOX1_ENST00000287701.10_Silent_p.V257V|HMBOX1_ENST00000444075.1_Silent_p.V257V|HMBOX1_ENST00000355231.5_Silent_p.V257V|HMBOX1_ENST00000524238.1_Silent_p.V257V|HMBOX1_ENST00000523613.1_Silent_p.V257V|HMBOX1_ENST00000403668.2_Silent_p.V257V|HMBOX1_ENST00000519047.1_Silent_p.V257V	NM_024567.3	NP_078843.2	Q6NT76	HMBX1_HUMAN	homeobox containing 1	257					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	11		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		CTCCCCCAGTCTCTGCCACAT	0.488000													16	48					0	0	1	0	0
CMTM1	113540	broad.mit.edu	37	16	66603842	66603842	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:66603842C>T	ENST00000379500.2	+	2	503	c.436C>T	c.(436-438)Ctt>Ttt	p.L146F	CMTM1_ENST00000332695.7_Intron|CMTM1_ENST00000533953.1_Intron|CMTM1_ENST00000533666.1_Intron|CMTM1_ENST00000529506.1_Intron|CMTM1_ENST00000528324.1_Missense_Mutation_p.L29F|CMTM1_ENST00000328020.6_Missense_Mutation_p.L146F|CMTM1_ENST00000531885.1_Intron|CKLF-CMTM1_ENST00000527729.1_Intron|CMTM1_ENST00000336328.6_Intron|CMTM1_ENST00000535705.1_Intron|CMTM1_ENST00000457188.2_Missense_Mutation_p.L29F	NM_052999.3|NM_181268.2	NP_443725.3|NP_851785.2	Q8IZ96	CKLF1_HUMAN	CKLF-like MARVEL transmembrane domain containing 1	29					chemotaxis	extracellular space|integral to membrane	cytokine activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		ATTGCAGAGTCTTATCTTAGG	0.323000													6	86					0	0	1	0	0
IGFL1	374918	broad.mit.edu	37	19	46733721	46733721	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:46733721G>A	ENST00000437936.1	+	3	293	c.270G>A	c.(268-270)ctG>ctA	p.L90L		NM_198541.1	NP_940943.1	Q6UW32	IGFL1_HUMAN	IGF-like family member 1	90						extracellular space	protein binding			lung(5)	5		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.00242)|all cancers(93;0.0132)|GBM - Glioblastoma multiforme(486;0.0294)|Epithelial(262;0.201)		TGGTGAAGCTGATAAACCAGA	0.587000													14	108					0	0	1	0	0
OR6A2	8590	broad.mit.edu	37	11	6816752	6816752	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:6816752A>C	ENST00000332601.3	-	1	376	c.188T>G	c.(187-189)tTt>tGt	p.F63C		NM_003696.2	NP_003687.2	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A, member 2	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(4)|pancreas(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	29		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATTAGCTAGAAAAAAGTACAT	0.448000													7	50					0	0	1	0	0
LZTS3	9762	broad.mit.edu	37	20	3145259	3145259	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:3145259C>G	ENST00000329152.3	-	3	3260	c.1863G>C	c.(1861-1863)ctG>ctC	p.L621L	LZTS3_ENST00000337576.5_Silent_p.L575L|LZTS3_ENST00000360342.3_Silent_p.L575L																							CCACGTAGCTCAGCTGCAGCT	0.701000													7	43					0	0	1	0	0
CLDN7	1366	broad.mit.edu	37	17	7165288	7165288	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:7165288G>A	ENST00000538261.3	-	1	976	c.75C>T	c.(73-75)acC>acT	p.T25T	CLDN7_ENST00000571881.2_Silent_p.T25T|CLDN7_ENST00000360325.7_Silent_p.T25T|RP1-4G17.5_ENST00000577138.1_Silent_p.T25T|CLDN7_ENST00000397317.4_Silent_p.T25T	NM_001185023.1	NP_001171952.1	O95471	CLD7_HUMAN	claudin 7	25					calcium-independent cell-cell adhesion	integral to membrane|lateral plasma membrane|tight junction	identical protein binding|structural molecule activity			kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	6						GCGGGATGGCGGTGCAGGCCA	0.632000													8	20					0	0	1	0	0
SHOX2	6474	broad.mit.edu	37	3	157815958	157815958	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:157815958G>C	ENST00000490689.2	-	5	1964	c.431C>G	c.(430-432)cCg>cGg	p.P144R	SHOX2_ENST00000441443.2_Missense_Mutation_p.P144R|SHOX2_ENST00000389589.4_Missense_Mutation_p.P309R|SHOX2_ENST00000425436.3_Missense_Mutation_p.P285R|SHOX2_ENST00000483851.2_Missense_Mutation_p.P273R			O60902	SHOX2_HUMAN	short stature homeobox 2	285					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(10)|skin(3)|upper_aerodigestive_tract(1)	20			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CGTGGCGAGCGGCAGTCCGAA	0.701000													4	148					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14838584	14838584	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrY:14838584T>A	ENST00000338981.3	+	7	1460	c.515T>A	c.(514-516)cTa>cAa	p.L172Q	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	172					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TTTCCACTTCTAGAACTTCTC	0.408000													38	33					0	0	1	0	0
TFEC	22797	broad.mit.edu	37	7	115624534	115624534	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:115624534G>A	ENST00000484212.1	-	4	406	c.232C>T	c.(232-234)Cag>Tag	p.Q78*	TFEC_ENST00000393485.1_5'UTR|TFEC_ENST00000265440.7_5'UTR|TFEC_ENST00000320239.7_5'UTR			O14948	TFEC_HUMAN	transcription factor EC	0	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			TTCTGTAGCTGAGGCCTTGCA	0.428000													8	33					0	0	1	0	0
PDIA6	10130	broad.mit.edu	37	2	10932044	10932044	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:10932044C>T	ENST00000404371.2	-	8	954	c.617G>A	c.(616-618)aGt>aAt	p.S206N	PDIA6_ENST00000272227.3_Missense_Mutation_p.S154N|PDIA6_ENST00000381611.4_Missense_Mutation_p.S159N|PDIA6_ENST00000404824.2_Missense_Mutation_p.S202N|PDIA6_ENST00000540494.1_Missense_Mutation_p.S151N	NM_001282704.1	NP_001269633.1	Q15084	PDIA6_HUMAN	protein disulfide isomerase family A, member 6	154	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding	endoplasmic reticulum lumen|ER-Golgi intermediate compartment|melanosome|plasma membrane	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|prostate(2)	18	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.149)|OV - Ovarian serous cystadenocarcinoma(76;0.15)		TGAACTATCACTTCTGCCCTG	0.368000													18	73					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171535888	171535888	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:171535888T>C	ENST00000367742.3	+	22	6706	c.6464T>C	c.(6463-6465)gTc>gCc	p.V2155A	PRRC2C_ENST00000392078.3_Missense_Mutation_p.V2155A|PRRC2C_ENST00000426496.2_Missense_Mutation_p.V2153A|PRRC2C_ENST00000338920.4_Missense_Mutation_p.V2153A			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	2153							protein C-terminus binding										ACAGATCCTGTCACGACAAAG	0.418000													9	13					0	0	1	0	0
CCNYL1	151195	broad.mit.edu	37	2	208618378	208618378	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:208618378G>A	ENST00000295414.3	+	10	1247	c.1036G>A	c.(1036-1038)Gat>Aat	p.D346N	CCNYL1_ENST00000468768.1_3'UTR|CCNYL1_ENST00000392209.3_Missense_Mutation_p.D276N|CCNYL1_ENST00000339882.5_Missense_Mutation_p.D295N			Q8N7R7	CCYL1_HUMAN	cyclin Y-like 1	346					regulation of cyclin-dependent protein kinase activity		protein kinase binding			endometrium(1)|large_intestine(1)|lung(3)	5				LUSC - Lung squamous cell carcinoma(261;0.0731)|Epithelial(149;0.139)|Lung(261;0.14)		TTTCAGTGCTGATAACTTCAT	0.403000													34	83					0	0	1	0	0
CLNK	116449	broad.mit.edu	37	4	10542221	10542221	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:10542221T>C	ENST00000226951.6	-	11	738	c.499A>G	c.(499-501)Ata>Gta	p.I167V	CLNK_ENST00000442825.2_Missense_Mutation_p.I125V|CLNK_ENST00000507719.1_Missense_Mutation_p.I125V	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	167	Pro-rich.				immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						GGAAGTGTTATGAGAGGCCTG	0.567000													13	19					0	0	1	0	0
RBM17	84991	broad.mit.edu	37	10	6154212	6154212	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:6154212C>T	ENST00000446108.1	+	8	1388	c.744C>T	c.(742-744)ttC>ttT	p.F248F	RBM17_ENST00000379888.4_Silent_p.F248F	NM_001145547.1	NP_001139019.1	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	248	G-patch.				mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	19						AGTACGGCTTCCGGGAGGGCC	0.597000													3	44					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61761113	61761113	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:61761113A>G	ENST00000423902.2	+	24	5729	c.5250A>G	c.(5248-5250)caA>caG	p.Q1750Q	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1750					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ACCTAAGACAAGAAGTGATAG	0.493000													6	10					0	0	1	0	0
DLG1	1739	broad.mit.edu	37	3	196921431	196921431	+	Silent	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:196921431A>T	ENST00000346964.2	-	5	537	c.348T>A	c.(346-348)ccT>ccA	p.P116P	DLG1_ENST00000422288.1_Silent_p.P116P|DLG1_ENST00000485409.1_5'UTR|DLG1_ENST00000419354.1_Silent_p.P116P|DLG1_ENST00000392382.2_Silent_p.P116P|DLG1_ENST00000448528.2_Silent_p.P116P|DLG1_ENST00000450955.1_Silent_p.P116P|DLG1_ENST00000314062.3_Silent_p.P116P|DLG1_ENST00000357674.4_Silent_p.P116P	NM_004087.2	NP_004078.2	Q12959	DLG1_HUMAN	discs, large homolog 1 (Drosophila)	116					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GCTCTTGAGGAGGTGTATCTT	0.358000													6	39					0	0	1	0	0
CCDC116	164592	broad.mit.edu	37	22	21988430	21988430	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:21988430G>A	ENST00000292779.3	+	3	353	c.192G>A	c.(190-192)aaG>aaA	p.K64K	CCDC116_ENST00000607942.1_Silent_p.K64K	NM_152612.2	NP_689825.2	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	64										endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(5)	22	Colorectal(54;0.105)					GCCGAAACAAGAGGCACCCTC	0.617000													21	85					0	0	1	0	0
DENND5A	23258	broad.mit.edu	37	11	9192205	9192205	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:9192205C>T	ENST00000328194.3	-	9	2346	c.2026G>A	c.(2026-2028)Gat>Aat	p.D676N	DENND5A_ENST00000527700.1_Missense_Mutation_p.D19N|DENND5A_ENST00000530044.1_Missense_Mutation_p.D676N	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	676										breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GAAAGTACATCAGACTGCAGC	0.468000													16	117					0	0	1	0	0
EPC2	26122	broad.mit.edu	37	2	149519350	149519350	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:149519350G>A	ENST00000258484.6	+	5	700		c.e5-1			NM_015630.3	NP_056445.3	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2 (Drosophila)						chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0516)		ATTTTTAATAGAATCGTAAGA	0.289000													2	2					0	0	1	0	0
ALPL	249	broad.mit.edu	37	1	21903941	21903941	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:21903941G>T	ENST00000374840.3	+	12	1625	c.1375G>T	c.(1375-1377)Gtg>Ttg	p.V459L	ALPL_ENST00000540617.1_Missense_Mutation_p.V404L|ALPL_ENST00000374830.1_Missense_Mutation_p.V105L|ALPL_ENST00000539907.1_Missense_Mutation_p.V382L|ALPL_ENST00000374832.1_Missense_Mutation_p.V459L|ALPL_ENST00000374829.1_Missense_Mutation_p.V105L|ALPL_ENST00000425315.2_Missense_Mutation_p.V459L	NM_000478.4	NP_000469.3	P05186	PPBT_HUMAN	alkaline phosphatase, liver/bone/kidney	459			V -> M (in HOPS; infantile).		response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	26		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	CGGGGAGGACGTGGCCGTCTT	0.672000													8	42					2.17888e-05	2.23087e-05	1	1	0
ARSJ	79642	broad.mit.edu	37	4	114824434	114824434	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:114824434G>A	ENST00000315366.7	-	2	1662	c.796C>T	c.(796-798)Caa>Taa	p.Q266*	ARSJ_ENST00000541197.1_Nonsense_Mutation_p.Q266*	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	266						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		TGAACAGCTTGATAGGCAATA	0.423000													32	58					0	0	1	0	0
GJB1	2705	broad.mit.edu	37	X	70443614	70443614	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:70443614C>T	ENST00000374022.3	+	2	152	c.57C>T	c.(55-57)gcC>gcT	p.A19A	GJB1_ENST00000361726.6_Silent_p.A19A|GJB1_ENST00000374029.1_Silent_p.A19A	NM_001097642.2	NP_001091111.1	P08034	CXB1_HUMAN	gap junction protein, beta 1, 32kDa	19					cell-cell signaling|cellular membrane organization|gap junction assembly|nervous system development	connexon complex|endoplasmic reticulum membrane|integral to membrane	gap junction channel activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(1)	10	Renal(35;0.156)					ATTCTACTGCCATTGGCCGAG	0.512000													12	27					0	0	1	0	0
IRS1	3667	broad.mit.edu	37	2	227660224	227660224	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:227660224G>A	ENST00000305123.5	-	1	4251	c.3231C>T	c.(3229-3231)ctC>ctT	p.L1077L		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1						fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GGTTAGGACTGAGGTTCACCC	0.647000													20	76					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196715047	196715047	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:196715047A>G	ENST00000367429.4	+	21	3651	c.3411A>G	c.(3409-3411)caA>caG	p.Q1137Q		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	1137	Sushi 19.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						TTGAGTACCAATGCCAGAACT	0.413000													9	127					0	0	1	0	0
HTRA3	94031	broad.mit.edu	37	4	8288502	8288502	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:8288502C>G	ENST00000307358.2	+	3	904	c.700C>G	c.(700-702)Cat>Gat	p.H234D	HTRA3_ENST00000382512.3_Missense_Mutation_p.H234D	NM_053044.3	NP_444272.1	P83110	HTRA3_HUMAN	HtrA serine peptidase 3	234	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|prostate(1)|urinary_tract(1)	18						CATCAAGATCCATCCCAAGGT	0.617000													3	13					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71495171	71495171	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:71495171G>T	ENST00000296755.7	+	5	6287	c.5989G>T	c.(5989-5991)Ggt>Tgt	p.G1997C		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1997						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CTCTGAGGATGGTGGCCACAC	0.478000													13	99					7.93312e-07	8.18157e-07	1	1	0
SLC6A10P	386757	broad.mit.edu	37	16	32893895	32893895	+	RNA	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:32893895C>T	ENST00000330048.5	-	0	1362					NR_003083.2																						GCAAGCTGGTCACAAGTGAGG	0.617000													5	88					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716530	142716530	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:142716530G>A	ENST00000381779.4	-	2	2620	c.2395C>T	c.(2395-2397)Cac>Tac	p.H799Y	SLITRK4_ENST00000356928.1_Missense_Mutation_p.H799Y|SLITRK4_ENST00000338017.4_Missense_Mutation_p.H799Y	NM_001184749.2|NM_001184750.1|NM_173078.4	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	799						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					ATTTTACTGTGGTTGCCACCT	0.423000													6	37					0	0	1	0	0
SEC61A2	55176	broad.mit.edu	37	10	12191960	12191960	+	Splice_Site	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:12191960G>T	ENST00000379033.3	+	5	543	c.396G>T	c.(394-396)caG>caT	p.Q132H	SEC61A2_ENST00000379017.3_Splice_Site_p.Q154H|SEC61A2_ENST00000379051.1_Splice_Site_p.Q154H|SEC61A2_ENST00000304267.8_Splice_Site_p.Q154H|SEC61A2_ENST00000495368.1_3'UTR|SEC61A2_ENST00000298428.9_Splice_Site_p.Q154H|SEC61A2_ENST00000379020.4_Splice_Site_p.Q154H	NM_001142628.1	NP_001136100.1	Q9H9S3	S61A2_HUMAN	Sec61 alpha 2 subunit (S. cerevisiae)	154						endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Renal(717;0.228)				TCATCATTCAGGTAAGAAATC	0.398000													7	81					0.0293803	0.0295473	1	1	0
ENAH	55740	broad.mit.edu	37	1	225686080	225686080	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:225686080T>G	ENST00000366844.3	-	14	2158	c.1707A>C	c.(1705-1707)gaA>gaC	p.E569D	ENAH_ENST00000284563.6_Missense_Mutation_p.E795D|ENAH_ENST00000366843.2_Missense_Mutation_p.E548D	NM_001008493.1|NM_018212.4	NP_001008493.1|NP_060682.2	Q8N8S7	ENAH_HUMAN	enabled homolog (Drosophila)		EVH2 block C.|EVH2.				axon guidance|intracellular transport|T cell receptor signaling pathway	cytosol|filopodium|focal adhesion|lamellipodium|synapse	actin binding|SH3 domain binding|WW domain binding			NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.19)		GCTTTGTTAATTCTTTTCTCA	0.264000													6	35					0	0	1	0	0
GINS4	84296	broad.mit.edu	37	8	41399354	41399354	+	Missense_Mutation	SNP	G	G	C	rs141719341	by1000genomes	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:41399354G>C	ENST00000523277.2	+	7	678	c.511G>C	c.(511-513)Gtg>Ctg	p.V171L	RP11-360L9.7_ENST00000524133.1_RNA|GINS4_ENST00000518671.1_Missense_Mutation_p.V171L|GINS4_ENST00000276533.3_Missense_Mutation_p.V171L|RP11-360L9.4_ENST00000523081.1_RNA			Q9BRT9	SLD5_HUMAN	GINS complex subunit 4 (Sld5 homolog)	171	Important for GINS complex assembly.				DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm				breast(1)|lung(2)|skin(1)	4	Ovarian(28;0.014)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.00732)|Lung NSC(58;0.0207)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00329)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			AGATTCTTACGTGTTTCTGAG	0.448000													6	45					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6046754	6046754	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:6046754C>T	ENST00000284898.6	-	17	1645		c.e17-1		L3MBTL4_ENST00000400105.2_Splice_Site|RP11-793A3.2_ENST00000577935.1_RNA|L3MBTL4_ENST00000535782.1_Intron|L3MBTL4_ENST00000317931.7_Intron|L3MBTL4_ENST00000400104.3_Intron	NM_173464.3	NP_775735.2	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)						chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				agcacaagcactgtgaagaga	0.323000													9	65					0	0	1	0	0
TBC1D3P5	440419	broad.mit.edu	37	17	25749260	25749260	+	RNA	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:25749260C>G	ENST00000586223.1	+	0	1161					NR_033892.1																						GATGAAAAATCCCAGAAAATA	0.512000													4	26					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111395637	111395637	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:111395637C>T	ENST00000535254.1	-	24	3169	c.3102G>A	c.(3100-3102)ctG>ctA	p.L1034L	BUB1_ENST00000409311.1_Silent_p.L997L|BUB1_ENST00000302759.6_Silent_p.L1054L	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	1054	Protein kinase.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity	p.L1054L(2)		breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATACTTTCTTCAGCTTTTGCC	0.338000													9	74					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38933076	38933076	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:38933076A>G	ENST00000274276.3	+	18	2872	c.2470A>G	c.(2470-2472)Agg>Ggg	p.R824G		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	824					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					CCTAGGCACTAGGAAGTCACT	0.443000													6	72					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47125589	47125589	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:47125589G>C	ENST00000409792.3	-	12	5723	c.5681C>G	c.(5680-5682)tCt>tGt	p.S1894C		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1894					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.S1894F(1)|p.S1391F(1)		breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GGTTGCATCAGAGATTGCACT	0.433000			"""N, F, S, Mis"""		clear cell renal carcinoma								23	251					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32640101	32640101	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:32640101C>T	ENST00000421745.2	+	10	1876	c.1742C>T	c.(1741-1743)tCa>tTa	p.S581L		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	581					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CCTGCTACCTCACCCATTAGT	0.398000													3	33					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236187393	236187393	+	Missense_Mutation	SNP	C	C	G	rs149309893	byFrequency	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:236187393C>G	ENST00000264187.6	-	9	2187	c.2105G>C	c.(2104-2106)cGa>cCa	p.R702P	NID1_ENST00000366595.3_Missense_Mutation_p.R702P	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	702	EGF-like 2.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CCCGTCTCCTCGGAAGCCGAT	0.582000													4	31					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34789559	34789559	+	Silent	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:34789559C>A	ENST00000192788.5	+	2	345	c.174C>A	c.(172-174)atC>atA	p.I58I	UHRF1BP1_ENST00000452449.2_Silent_p.I58I	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	58										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						GGTTAGCCATCACTCGGGTCT	0.562000													4	44					0.184627	0.185019	1	1	0
NUAK2	81788	broad.mit.edu	37	1	205273395	205273395	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:205273395T>C	ENST00000367157.3	-	7	1196	c.1070A>G	c.(1069-1071)cAt>cGt	p.H357R		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	357					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACCAGGTGCATGCTGCTTGAA	0.642000													3	26					0	0	1	0	0
ASPH	444	broad.mit.edu	37	8	62593548	62593548	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:62593548C>T	ENST00000541428.1	-	3	374	c.214G>A	c.(214-216)Gat>Aat	p.D72N	ASPH_ENST00000379454.4_Missense_Mutation_p.D101N|ASPH_ENST00000517856.1_Missense_Mutation_p.D101N|ASPH_ENST00000517661.1_Missense_Mutation_p.D87N|ASPH_ENST00000445642.3_Missense_Mutation_p.D87N|ASPH_ENST00000517903.1_Missense_Mutation_p.D87N|ASPH_ENST00000379449.6_Missense_Mutation_p.D116N|ASPH_ENST00000517847.2_Missense_Mutation_p.D87N|ASPH_ENST00000522835.1_Missense_Mutation_p.D87N|ASPH_ENST00000522603.1_Missense_Mutation_p.D72N|ASPH_ENST00000518068.1_Missense_Mutation_p.D101N|ASPH_ENST00000356457.5_Missense_Mutation_p.D101N|ASPH_ENST00000389204.4_Missense_Mutation_p.D87N	NM_001164750.1	NP_001158222.1	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase	101					muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			breast(1)|cervix(1)|endometrium(5)|large_intestine(5)|lung(16)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	TTGGCATCATCCACATCAAAA	0.294000													30	152					0	0	1	0	0
ID1	3397	broad.mit.edu	37	20	30193235	30193235	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:30193235C>T	ENST00000376105.3	+	1	144	c.45C>T	c.(43-45)ccC>ccT	p.P15P	ID1_ENST00000376112.3_Silent_p.P15P	NM_181353.2	NP_851998.1	P41134	ID1_HUMAN	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	15					angiogenesis|blood vessel endothelial cell migration|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by transcription factor localization|transforming growth factor beta receptor signaling pathway	cytoplasm	protein binding			endometrium(2)|ovary(1)|pancreas(1)	4	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.99e-05)|all cancers(5;0.000169)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			CCGCGGGCCCCAGCTGCGCGC	0.662000													3	32					0	0	1	0	0
DHX32	55760	broad.mit.edu	37	10	127525279	127525279	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:127525279C>T	ENST00000284690.3	-	11	2699	c.2209G>A	c.(2209-2211)Gaa>Aaa	p.E737K	DHX32_ENST00000368721.1_Missense_Mutation_p.E361K|BCCIP_ENST00000299130.3_Intron|DHX32_ENST00000284688.6_Missense_Mutation_p.E656K|BCCIP_ENST00000368759.5_Intron|BCCIP_ENST00000429863.2_Intron	NM_018180.2	NP_060650.2	Q7L7V1	DHX32_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 32	737						mitochondrion|nucleus	ATP binding|helicase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|stomach(1)	29		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CATCTCTGTTCAGTTTCAGGG	0.483000													6	48					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18435275	18435275	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:18435275A>T	ENST00000433979.1	+	2	376	c.260A>T	c.(259-261)aAt>aTt	p.N87I	PIK3C2G_ENST00000538779.1_Missense_Mutation_p.N87I|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.N87I|PIK3C2G_ENST00000535651.1_Missense_Mutation_p.N87I|RERGL_ENST00000541632.1_Intron	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	87					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				ATATCCTTGAATGAATTCACT	0.403000													13	133					0	0	1	0	0
CTSB	1508	broad.mit.edu	37	8	11703298	11703298	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:11703298C>G	ENST00000353047.6	-	9	1047	c.794G>C	c.(793-795)gGa>gCa	p.G265A	CTSB_ENST00000534510.1_Splice_Site_p.G265A|CTSB_ENST00000345125.3_Splice_Site_p.G265A|CTSB_ENST00000453527.2_Splice_Site_p.G265A|CTSB_ENST00000533455.1_Splice_Site_p.G265A|CTSB_ENST00000531089.1_Splice_Site_p.G265A|CTSB_ENST00000434271.1_Splice_Site_p.G265A|CTSB_ENST00000530640.2_Splice_Site_p.G265A|CTSB_ENST00000415599.2_3'UTR	NM_001908.3	NP_001899.1	P07858	CATB_HUMAN	cathepsin B	265					proteolysis|regulation of apoptosis|regulation of catalytic activity	lysosome|melanosome	cysteine-type endopeptidase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(1)	16	all_epithelial(15;0.205)		STAD - Stomach adenocarcinoma(15;0.00546)	COAD - Colon adenocarcinoma(149;0.184)		TTGGTACACTCCTGAAAAGGG	0.612000													5	18					0	0	1	0	0
FAM221B	392307	broad.mit.edu	37	9	35826102	35826102	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:35826102G>T	ENST00000423537.2	-	2	326	c.57C>A	c.(55-57)caC>caA	p.H19Q	TMEM8B_ENST00000377996.1_Intron	NM_001012446.3	NP_001012448.2	A6H8Z2	CI128_HUMAN	family with sequence similarity 221, member B	19										endometrium(2)|kidney(1)|lung(4)	7						TTGAAGGGGGGTGCTTCTCTG	0.488000											OREG0019180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	37					1.56452e-12	1.63375e-12	1	1	0
C2orf43	60526	broad.mit.edu	37	2	21001202	21001202	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:21001202C>T	ENST00000237822.3	-	2	101	c.22G>A	c.(22-24)Gaa>Aaa	p.E8K	C2orf43_ENST00000435420.2_Missense_Mutation_p.E8K|C2orf43_ENST00000419825.2_Missense_Mutation_p.E8K|C2orf43_ENST00000403006.2_Intron|C2orf43_ENST00000440866.2_Missense_Mutation_p.E8K|C2orf43_ENST00000541941.1_Intron|C2orf43_ENST00000381090.3_Missense_Mutation_p.E8K	NM_001282721.1|NM_021925.2	NP_001269650.1|NP_068744.1	Q9H6V9	CB043_HUMAN	chromosome 2 open reading frame 43	8										endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|stomach(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAGGAATTTCTTCCTTGAGT	0.393000													7	87					0	0	1	0	0
TBATA	219793	broad.mit.edu	37	10	72539348	72539348	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:72539348C>T	ENST00000299290.1	-	5	817		c.e5+1		TBATA_ENST00000545575.1_Splice_Site|TBATA_ENST00000456372.2_Splice_Site	NM_152710.2	NP_689923			thymus, brain and testes associated																		CAAGTACCCACCAGAAGAAAG	0.582000													3	21					0	0	1	0	0
OSM	5008	broad.mit.edu	37	22	30659896	30659896	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:30659896C>T	ENST00000215781.2	-	3	775	c.735G>A	c.(733-735)atG>atA	p.M245I	OSM_ENST00000403389.1_Missense_Mutation_p.M224I	NM_020530.4	NP_065391.1	P13725	ONCM_HUMAN	oncostatin M	245					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|skin(3)	11			Epithelial(10;0.206)			GTCCCCTGGTCATGAGTCTCT	0.662000													15	95					0	0	1	0	0
KRT24	192666	broad.mit.edu	37	17	38856528	38856528	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:38856528G>C	ENST00000264651.2	-	4	1019	c.963C>G	c.(961-963)taC>taG	p.Y321*		NM_019016.2	NP_061889.2	Q2M2I5	K1C24_HUMAN	keratin 24	321	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00526)				CCAGCTCCTCGTACTGCGCCC	0.552000													14	240					0	0	1	0	0
ZSCAN32	54925	broad.mit.edu	37	16	3432908	3432908	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:3432908G>C	ENST00000396852.4	-	7	2345	c.2038C>G	c.(2038-2040)Cag>Gag	p.Q680E	ZSCAN32_ENST00000304926.3_Missense_Mutation_p.Q468E|ZSCAN32_ENST00000439568.2_Missense_Mutation_p.Q391E|NAA60_ENST00000576906.1_Intron|ZSCAN32_ENST00000396846.3_Missense_Mutation_p.Q680E	NM_001284527.1|NM_001284529.1	NP_001271456.1|NP_001271458.1			zinc finger and SCAN domain containing 32																		TGTACTGTCTGATGACGGGTG	0.483000													10	79					0	0	1	0	0
COPG1	22820	broad.mit.edu	37	3	128979519	128979519	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:128979519G>A	ENST00000314797.6	+	12	1101	c.997G>A	c.(997-999)Gtc>Atc	p.V333I		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	333					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										GGAGAACCTGGTCACAGATTC	0.557000													8	61					0	0	1	0	0
RBMS2	5939	broad.mit.edu	37	12	56965591	56965591	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:56965591G>C	ENST00000262031.5	+	5	589	c.494G>C	c.(493-495)cGt>cCt	p.R165P	RBMS2_ENST00000542360.1_Intron|RBMS2_ENST00000550726.1_Missense_Mutation_p.R40P|RBMS2_ENST00000552247.2_Missense_Mutation_p.R165P	NM_002898.3	NP_002889.1	Q15434	RBMS2_HUMAN	RNA binding motif, single stranded interacting protein 2	165	RRM 2.				RNA processing	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(3)|skin(2)|urinary_tract(1)	18						ATCTCCACCCGTATCCTTCGA	0.502000													4	44					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140275363	140275363	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:140275363C>T	ENST00000458420.3	+	11	1873	c.1683C>T	c.(1681-1683)ttC>ttT	p.F561F		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	561					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						AGTATCACTTCAACCCCTCGC	0.493000										HNSCC(16;0.037)			5	116					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139906654	139906654	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:139906654A>G	ENST00000297183.6	+	27	5206	c.5082A>G	c.(5080-5082)gtA>gtG	p.V1694V	ANKHD1_ENST00000544120.1_Silent_p.V77V|ANKHD1-EIF4EBP3_ENST00000532219.1_Silent_p.V1694V|ANKHD1_ENST00000360839.2_Silent_p.V1694V	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAAGTTGTACGAAGGTAAA	0.358000													12	17					0	0	1	0	0
SMEK1	55671	broad.mit.edu	37	14	91948276	91948276	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:91948276C>T	ENST00000554684.1	-	4	1055	c.559G>A	c.(559-561)Gaa>Aaa	p.E187K	SMEK1_ENST00000554943.1_Missense_Mutation_p.E187K|SMEK1_ENST00000555462.1_Intron|SMEK1_ENST00000337238.4_Missense_Mutation_p.E187K|SMEK1_ENST00000428424.2_Intron	NM_001284280.1	NP_001271209.1	Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	187						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|liver(1)|lung(1)|stomach(1)	6		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		TGCAGTCCTTCAATATTTTCC	0.368000													5	60					0	0	1	0	0
FPGS	2356	broad.mit.edu	37	9	130569504	130569504	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:130569504C>T	ENST00000373245.1	+	6	568	c.518C>T	c.(517-519)tCc>tTc	p.S173F	FPGS_ENST00000373247.2_Missense_Mutation_p.S173F|FPGS_ENST00000393706.2_Intron|FPGS_ENST00000460181.1_3'UTR|FPGS_ENST00000373225.3_Missense_Mutation_p.S123F			Q05932	FOLC_HUMAN	folylpolyglutamate synthase	173					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7					L-Glutamic Acid(DB00142)	AGCTGTGTCTCCATGCCCCCC	0.612000													10	89					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17596867	17596867	+	Silent	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:17596867C>A	ENST00000375460.3	+	7	832	c.792C>A	c.(790-792)ctC>ctA	p.L264L		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	264					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TCACAGGACTCATCTCCTTCC	0.582000													25	33					2.44723e-14	2.56497e-14	1	1	0
CASP8	841	broad.mit.edu	37	2	202150039	202150039	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:202150039C>T	ENST00000358485.4	+	8	1676	c.1480C>T	c.(1480-1482)Cga>Tga	p.R494*	CASP8_ENST00000264275.5_Splice_Site_p.R452*|CASP8_ENST00000392266.3_3'UTR|CASP8_ENST00000392259.2_3'UTR|CASP8_ENST00000323492.7_Splice_Site_p.R420*|CASP8_ENST00000432109.2_Splice_Site_p.R435*|CASP8_ENST00000264274.9_Splice_Site_p.R351*	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	435					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding	p.R452*(2)|p.R494*(1)		breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						GCGATGTCCTCGGTAAGTTTT	0.502000										HNSCC(4;0.00038)			7	47					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106075003	106075003	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:106075003G>A	ENST00000278071.2	-	3	1259	c.807C>T	c.(805-807)ctC>ctT	p.L269L	ITPRIP_ENST00000337478.1_Silent_p.L269L|ITPRIP_ENST00000358187.2_Silent_p.L269L	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	269						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						TGCCGTGCAGGAGACACAGCA	0.607000													9	41					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118623924	118623924	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:118623924C>T	ENST00000336338.5	-	15	2074	c.2009G>A	c.(2008-2010)aGa>aAa	p.R670K		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	670						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AAATAGTGTTCTGTCTTTGAT	0.343000													22	52					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55144103	55144103	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:55144103A>G	ENST00000257290.5	+	14	2263	c.1932A>G	c.(1930-1932)gaA>gaG	p.E644E	FIP1L1_ENST00000507166.1_Silent_p.E404E	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	644	Protein kinase.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TCATGTCTGAACTGAAGATAA	0.468000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			13	26					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186308831	186308831	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:186308831G>A	ENST00000367478.4	-	30	4390	c.4094C>T	c.(4093-4095)aCt>aTt	p.T1365I		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		AATACGCTTAGTATGAACTTC	0.318000			T	NTRK1	papillary thyroid								8	101					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35243628	35243628	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:35243628G>A	ENST00000360310.1	-	19	3469	c.2902C>T	c.(2902-2904)Cag>Tag	p.Q968*	BAZ1A_ENST00000358716.4_Nonsense_Mutation_p.Q936*|BAZ1A_ENST00000382422.2_Nonsense_Mutation_p.Q968*	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	968					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		GCACACATCTGAGATGGATCA	0.363000													19	76					0	0	1	0	0
MAPK14	1432	broad.mit.edu	37	6	36043700	36043700	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:36043700C>T	ENST00000229795.3	+	7	1018	c.571C>T	c.(571-573)Cct>Tct	p.P191S	MAPK14_ENST00000310795.4_Missense_Mutation_p.P191S|MAPK14_ENST00000229794.4_Missense_Mutation_p.P191S|MAPK14_ENST00000468133.1_Missense_Mutation_p.P114S	NM_001315.2	NP_001306.1	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14	191	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|stomach(1)	16						GTACAGGGCTCCTGAGATCAT	0.463000													3	39					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46275985	46275985	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:46275985C>T	ENST00000372004.3	+	18	3637	c.3421C>T	c.(3421-3423)Cag>Tag	p.Q1141*	NCOA3_ENST00000371998.3_Nonsense_Mutation_p.Q1141*|NCOA3_ENST00000341724.6_Nonsense_Mutation_p.Q1071*|NCOA3_ENST00000371997.3_Nonsense_Mutation_p.Q1136*	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1141	Acetyltransferase.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TATGATGAATCAGATGAACCA	0.488000													5	54					0	0	1	0	0
ACBD6	84320	broad.mit.edu	37	1	180366740	180366740	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:180366740C>T	ENST00000367595.3	-	6	1261	c.574G>A	c.(574-576)Ggt>Agt	p.G192S	ACBD6_ENST00000475338.2_5'UTR	NM_032360.3	NP_115736.1	Q9BR61	ACBD6_HUMAN	acyl-CoA binding domain containing 6	192						cytoplasm|nucleus	fatty-acyl-CoA binding		ACBD6/RRP15(2)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|ovary(1)	7						AGAGCCCTACCCTAAAAACAC	0.373000													40	160					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124165631	124165631	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:124165631A>G	ENST00000360013.3	+	21	3572	c.3445A>G	c.(3445-3447)Aca>Gca	p.T1149A	KALRN_ENST00000240874.3_Missense_Mutation_p.T1149A|KALRN_ENST00000460856.1_Missense_Mutation_p.T1140A	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1149					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GATCCAAGAAACAGGTGAATT	0.473000													25	103					0	0	1	0	0
ZNF614	80110	broad.mit.edu	37	19	52519935	52519935	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:52519935G>A	ENST00000270649.6	-	5	1460	c.916C>T	c.(916-918)Cag>Tag	p.Q306*	ZNF614_ENST00000356322.6_Intron	NM_025040.3	NP_079316.2	Q8N883	ZN614_HUMAN	zinc finger protein 614	306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TGAGTTCGCTGATGAGCAATT	0.408000													30	144					0	0	1	0	0
GLCCI1	113263	broad.mit.edu	37	7	8043583	8043583	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:8043583G>A	ENST00000223145.5	+	2	1060	c.503G>A	c.(502-504)aGg>aAg	p.R168K	RPA3-AS1_ENST00000469183.1_3'UTR|GLCCI1_ENST00000474269.1_3'UTR	NM_138426.3	NP_612435.1	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	168										endometrium(4)|large_intestine(4)|lung(13)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	25		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		AGTACAATAAGGCGAACCTCC	0.403000													15	65					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	101023077	101023077	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:101023077C>T	ENST00000193391.7	-	3	601	c.414G>A	c.(412-414)atG>atA	p.M138I		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	138					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						CACACAAATTCATCCAGTAAT	0.408000													18	77					0	0	1	0	0
SCAF4	57466	broad.mit.edu	37	21	33057434	33057434	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:33057434C>T	ENST00000286835.7	-	19	2798	c.2416G>A	c.(2416-2418)Ggc>Agc	p.G806S	SCAF4_ENST00000434667.3_Missense_Mutation_p.G791S|SCAF4_ENST00000399804.1_Missense_Mutation_p.G784S	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	806						nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						ACGGCAGAGCCATACATTTTC	0.468000													20	71					0	0	1	0	0
PAN3	255967	broad.mit.edu	37	13	28851387	28851387	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:28851387T>A	ENST00000399613.1	+	14	1526	c.1463T>A	c.(1462-1464)aTa>aAa	p.I488K	PAN3_ENST00000380958.3_Missense_Mutation_p.I688K|PAN3_ENST00000282391.5_Missense_Mutation_p.I376K			Q58A45	PAN3_HUMAN	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	688	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		GCAGATCTGATATCATTAGGA	0.358000													11	73					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41009477	41009477	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:41009477C>T	ENST00000399564.4	-	32	3775	c.3325G>A	c.(3325-3327)Gaa>Aaa	p.E1109K	MROH2B_ENST00000506092.2_Missense_Mutation_p.E664K	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GCTGGCTTTTCAGCCAGCGCC	0.498000													33	80					0	0	1	0	0
MED12	9968	broad.mit.edu	37	X	70342961	70342961	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:70342961A>G	ENST00000333646.6	+	11	1701	c.1502A>G	c.(1501-1503)gAt>gGt	p.D501G	MED12_ENST00000374102.1_Missense_Mutation_p.D501G|MED12_ENST00000374080.3_Missense_Mutation_p.D501G	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	501					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					TCAGATGATGATGCTGTGGTG	0.507000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						31	35					0	0	1	0	0
ZNF420	147923	broad.mit.edu	37	19	37619711	37619711	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:37619711G>C	ENST00000337995.3	+	5	2033	c.1818G>C	c.(1816-1818)caG>caC	p.Q606H	CTC-454I21.4_ENST00000587645.1_RNA|ZNF420_ENST00000586540.1_3'UTR|ZNF585A_ENST00000588723.1_Intron|ZNF420_ENST00000304239.7_Intron	NM_144689.3	NP_653290.2	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	606					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|large_intestine(9)|lung(10)|prostate(1)|skin(3)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTCTACATCAGAGAATCCATA	0.443000													16	41					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	7026936	7026936	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:7026936T>C	ENST00000409757.4	+	13	2087	c.1963T>C	c.(1963-1965)Ttt>Ctt	p.F655L	TBC1D14_ENST00000410031.1_Missense_Mutation_p.F427L|TBC1D14_ENST00000451522.2_Missense_Mutation_p.F375L|TBC1D14_ENST00000446947.2_Missense_Mutation_p.F302L|TBC1D14_ENST00000448507.1_Missense_Mutation_p.F655L	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	655						intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						CGAGGAGCTGTTTGCCTCCAT	0.592000													19	27					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	12990024	12990024	+	Missense_Mutation	SNP	G	G	A	rs112329671	byFrequency	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:12990024G>A	ENST00000399002.2	+	1	383	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K	SPTLC3_ENST00000476791.1_3'UTR|SPTLC3_ENST00000378194.4_Missense_Mutation_p.E37K	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	37					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	AATAGTGAAGGAAGCCCAGGT	0.443000													15	38					0	0	1	0	0
ZNF384	171017	broad.mit.edu	37	12	6776900	6776900	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:6776900C>T	ENST00000396795.1	-	9	2028	c.1531G>A	c.(1531-1533)Gag>Aag	p.E511K	ZNF384_ENST00000355772.4_Missense_Mutation_p.E456K|ZNF384_ENST00000319770.3_Missense_Mutation_p.E495K|RP4-761J14.8_ENST00000589924.1_RNA|ZNF384_ENST00000396801.3_Missense_Mutation_p.E572K|ZNF384_ENST00000396799.2_Missense_Mutation_p.E511K|ZNF384_ENST00000361959.3_Missense_Mutation_p.E572K			Q8TF68	ZN384_HUMAN	zinc finger protein 384	572	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						GCCAGGTGCTCCACCTGGATG	0.557000			T	"""EWSR1, TAF15 """	ALL								27	119					0	0	1	0	0
WFDC8	90199	broad.mit.edu	37	20	44180784	44180784	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:44180784G>A	ENST00000357199.4	-	6	685	c.607C>T	c.(607-609)Cgc>Tgc	p.R203C	WFDC8_ENST00000289953.2_Missense_Mutation_p.R203C	NM_181510.2	NP_852611.2	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8	203	WAP 3.					extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|stomach(1)|upper_aerodigestive_tract(1)	15		Myeloproliferative disorder(115;0.0122)				AAGGGCTTGCGTGGGCAGAAA	0.423000													13	121					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56356968	56356968	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:56356968G>C	ENST00000340482.3	-	4	640	c.464C>G	c.(463-465)tCa>tGa	p.S155*	MPO_ENST00000225275.3_Nonsense_Mutation_p.S155*			P05164	PERM_HUMAN	myeloperoxidase	155					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	GCAGCCGCTTGACTTGGACAA	0.627000													3	30					0	0	1	0	0
OR5J2	282775	broad.mit.edu	37	11	55944898	55944898	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:55944898G>A	ENST00000312298.1	+	1	805	c.805G>A	c.(805-807)Gaa>Aaa	p.E269K		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					GTATTTTGTGGAACAAGAGAA	0.438000													4	78					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134072435	134072435	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:134072435C>T	ENST00000264360.5	+	1	1966	c.1140C>T	c.(1138-1140)ttC>ttT	p.F380F		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10		Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		TGGCCCTTTTCAGCGTGACTG	0.577000													16	50					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27106907	27106907	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:27106907A>T	ENST00000324856.7	+	20	6889	c.6518A>T	c.(6517-6519)aAc>aTc	p.N2173I	ARID1A_ENST00000540690.1_Missense_Mutation_p.N501I|ARID1A_ENST00000374152.2_Missense_Mutation_p.N1790I|ARID1A_ENST00000457599.2_Missense_Mutation_p.N1956I	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	2173					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTGCTGGCCAACCTGGCTCAG	0.612000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								4	67					0	0	1	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182869338	182869338	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:182869338T>C	ENST00000367547.3	-	10	1978	c.1742A>G	c.(1741-1743)aAt>aGt	p.N581S	SHCBP1L_ENST00000423786.1_Missense_Mutation_p.N462S|SHCBP1L_ENST00000488956.1_5'UTR	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	653										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						AATATGATTATTAGTCATCTT	0.299000													41	53					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63553946	63553946	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:63553946C>T	ENST00000307078.5	-	2	1106	c.793G>A	c.(793-795)Gaa>Aaa	p.E265K	CTD-2535L24.2_ENST00000577662.1_3'UTR|AXIN2_ENST00000375702.5_Missense_Mutation_p.E265K	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	265					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						TCAACAGTTTCCGTGGACCTC	0.542000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				15	52					0	0	1	0	0
SYNRG	11276	broad.mit.edu	37	17	35931957	35931957	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:35931957C>T	ENST00000339208.6	-	9	1171	c.1031G>A	c.(1030-1032)cGa>cAa	p.R344Q	SYNRG_ENST00000394378.2_Missense_Mutation_p.R266Q|SYNRG_ENST00000346661.4_Missense_Mutation_p.R344Q|SYNRG_ENST00000585472.1_Missense_Mutation_p.R265Q|SYNRG_ENST00000591288.1_Missense_Mutation_p.R266Q|SYNRG_ENST00000588194.1_5'UTR|SYNRG_ENST00000502449.2_Missense_Mutation_p.R266Q|SYNRG_ENST00000345615.4_Missense_Mutation_p.R266Q	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	344	EH.				endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AGGTGTAGTTCGATTAGCTAA	0.408000													22	87					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109347256	109347256	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:109347256A>G	ENST00000283195.6	+	3	293	c.167A>G	c.(166-168)cAa>cGa	p.Q56R		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	56					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						ATTAATGTGCAAGAGAGGGAT	0.328000													37	239					0	0	1	0	0
AMACR	23600	broad.mit.edu	37	5	34008101	34008101	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:34008101G>A	ENST00000335606.6	-	1	112	c.24C>T	c.(22-24)gtC>gtT	p.V8V	AMACR_ENST00000441713.2_Silent_p.V8V|AMACR_ENST00000512079.1_Silent_p.V8V|AMACR_ENST00000382085.3_Silent_p.V8V|RP11-1084J3.4_ENST00000382079.3_Intron|AMACR_ENST00000502637.1_Silent_p.V8V|AMACR_ENST00000382068.3_Silent_p.V8V|AMACR_ENST00000382072.2_Silent_p.V8V|AMACR_ENST00000426255.2_Silent_p.V8V|AMACR_ENST00000514195.1_5'UTR	NM_001167595.1|NM_014324.5	NP_001161067.1|NP_055139.4	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase	8					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	19						ACAGCTCCACGACCGAGATGC	0.692000													5	21					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58330357	58330357	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:58330357C>T	ENST00000371015.1	+	4	946	c.479C>T	c.(478-480)aCt>aTt	p.T160I	PHACTR3_ENST00000395639.4_Missense_Mutation_p.T119I|PHACTR3_ENST00000541461.1_Missense_Mutation_p.T119I|PHACTR3_ENST00000355648.4_Missense_Mutation_p.T119I|PHACTR3_ENST00000359926.3_Missense_Mutation_p.T157I|PHACTR3_ENST00000361300.4_Missense_Mutation_p.T119I|PHACTR3_ENST00000395636.2_Missense_Mutation_p.T119I	NM_001281507.1|NM_080672.3	NP_001268436.1|NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	160						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CCCTTGGCCACTGGGACGGAC	0.612000													3	13					0	0	1	0	0
SLC26A6	65010	broad.mit.edu	37	3	48665960	48665960	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:48665960G>A	ENST00000358747.6	-	15	1894	c.1644C>T	c.(1642-1644)gtC>gtT	p.V548V	SLC26A6_ENST00000420764.2_Silent_p.V569V|SLC26A6_ENST00000337000.8_Silent_p.V462V|SLC26A6_ENST00000395550.2_Silent_p.V569V|SLC26A6_ENST00000455886.2_Silent_p.V533V|SLC26A6_ENST00000383733.3_Silent_p.V569V	NM_001040454.1	NP_001035544.1			solute carrier family 26 (anion exchanger), member 6										SLC26A6/PRKAR2A(2)	NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		TGAGGAAGTCGACATCCACAC	0.562000													55	78					0	0	1	0	0
SESTD1	91404	broad.mit.edu	37	2	179997075	179997075	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:179997075G>A	ENST00000428443.3	-	10	1244	c.928C>T	c.(928-930)Cag>Tag	p.Q310*		NM_178123.4	NP_835224.3	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	310					regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(3)	30			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			TGTAGGGCCTGGGAGGCCCTA	0.468000													34	228					0	0	1	0	0
CHRNB1	1140	broad.mit.edu	37	17	7348645	7348645	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:7348645G>C	ENST00000306071.2	+	2	182	c.115G>C	c.(115-117)Gat>Cat	p.D39H	RP11-104H15.10_ENST00000575331.1_RNA	NM_000747.2	NP_000738.2	P11230	ACHB_HUMAN	cholinergic receptor, nicotinic, beta 1 (muscle)	39					behavioral response to nicotine|muscle contraction|muscle fiber development|neuromuscular synaptic transmission|postsynaptic membrane organization|regulation of membrane potential|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine binding|receptor activity			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|ovary(3)	23		Prostate(122;0.157)				CTCTGGCTATGATAGCTCCGT	0.667000													3	21					0	0	1	0	0
DOLK	22845	broad.mit.edu	37	9	131708232	131708232	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:131708232C>T	ENST00000372586.3	-	1	1666	c.1351G>A	c.(1351-1353)Gat>Aat	p.D451N	RP11-101E3.5_ENST00000482796.1_Intron	NM_014908.3	NP_055723.1	Q9UPQ8	DOLK_HUMAN	dolichol kinase	451					dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity			breast(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	11						GCCACAGTATCACCCACACCC	0.587000													10	72					0	0	1	0	0
TRNT1	51095	broad.mit.edu	37	3	3186273	3186273	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:3186273G>C	ENST00000251607.6	+	5	589	c.487G>C	c.(487-489)Gat>Cat	p.D163H	TRNT1_ENST00000280591.6_Missense_Mutation_p.D163H	NM_182916.2	NP_886552	Q96Q11	TRNT1_HUMAN	tRNA nucleotidyl transferase, CCA-adding, 1	163					protein targeting to mitochondrion|tRNA 3'-end processing	mitochondrion	ATP binding|tRNA adenylyltransferase activity|tRNA binding			breast(2)|endometrium(3)|large_intestine(4)|lung(2)|urinary_tract(1)	12				Epithelial(13;0.00226)|OV - Ovarian serous cystadenocarcinoma(96;0.00592)|all cancers(10;0.011)		AATAGGTTTTGATGGCACTTT	0.289000													24	77					0	0	1	0	0
SH2D2A	9047	broad.mit.edu	37	1	156786476	156786476	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:156786476A>G	ENST00000392306.2	-	1	164	c.25T>C	c.(25-27)Tgt>Cgt	p.C9R	SH2D2A_ENST00000495306.1_5'UTR|NTRK1_ENST00000392302.2_Intron|SH2D2A_ENST00000368198.3_Start_Codon_SNP_p.M1T|SH2D2A_ENST00000368199.3_Missense_Mutation_p.C9R	NM_001161441.1	NP_001154913.1	Q9NP31	SH22A_HUMAN	SH2 domain containing 2A	9					angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|large_intestine(2)|lung(15)	18	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCTTGGGGACATATCTGGGCC	0.587000													10	35					0	0	1	0	0
HIST2H2AB	317772	broad.mit.edu	37	1	149859299	149859299	+	Silent	SNP	G	G	C	rs140091148	byFrequency	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:149859299G>C	ENST00000331128.3	-	1	167	c.168C>G	c.(166-168)ctC>ctG	p.L56L		NM_175065.2	NP_778235.1	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	56					nucleosome assembly	nucleosome|nucleus	DNA binding	p.L56L(1)		breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TCAGGTACTCGAGGACCGCCG	0.667000													40	60					0	0	1	0	0
RBP4	5950	broad.mit.edu	37	10	95360732	95360732	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:95360732C>T	ENST00000371467.1	-	2	373	c.54G>A	c.(52-54)gcG>gcA	p.A18A	RBP4_ENST00000371469.2_Intron|FFAR4_ENST00000604414.1_Intron|RBP4_ENST00000371464.3_Silent_p.A18A			P02753	RET4_HUMAN	retinol binding protein 4, plasma	18					cardiac muscle tissue development|embryonic organ morphogenesis|embryonic retina morphogenesis in camera-type eye|embryonic skeletal system development|female genitalia morphogenesis|gluconeogenesis|glucose homeostasis|heart trabecula formation|lung development|maintenance of gastrointestinal epithelium|negative regulation of cardiac muscle cell proliferation|positive regulation of immunoglobulin secretion|positive regulation of insulin secretion|response to retinoic acid|retinol metabolic process|urinary bladder development|uterus development|vagina development	extracellular space	protein binding|retinal binding|retinol binding			large_intestine(1)|lung(3)|skin(1)	5		Colorectal(252;0.122)			Vitamin A(DB00162)	AGTCGCGCTCCGCGCGGCCGC	0.701000													5	27					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090778	9090778	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:9090778G>A	ENST00000397910.4	-	1	1240	c.1037C>T	c.(1036-1038)aCa>aTa	p.T346I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	346	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGAGGAAATTGTGCTTCTGAC	0.517000													12	38					0	0	1	0	0
MOXD1	26002	broad.mit.edu	37	6	132643947	132643947	+	Silent	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:132643947C>G	ENST00000367963.3	-	8	1294	c.1176G>C	c.(1174-1176)ctG>ctC	p.L392L	MOXD1_ENST00000336749.3_Silent_p.L324L|MOXD1_ENST00000489128.1_5'UTR	NM_015529.2	NP_056344.2	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1	392					catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		CTCTGCCAGCCAGGTGAGCAT	0.468000													11	22					0	0	1	0	0
ZNF252P	286101	broad.mit.edu	37	8	146220343	146220343	+	RNA	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:146220343G>A	ENST00000426361.2	-	0	245					NR_023392.1															endometrium(1)	1						TGTTCCTGCTGGGCCCCAGCT	0.557000													3	10					0	0	1	0	0
ZNF394	84124	broad.mit.edu	37	7	99091253	99091253	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:99091253C>G	ENST00000337673.6	-	3	1788	c.1585G>C	c.(1585-1587)Gaa>Caa	p.E529Q	ZNF394_ENST00000426306.2_3'UTR|ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000493485.1_Intron	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	529					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TCCCCACATTCAAGACATTTG	0.458000													22	111					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57395167	57395167	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:57395167C>T	ENST00000543257.1	-	13	2096	c.1530G>A	c.(1528-1530)aaG>aaA	p.K510K	C8B_ENST00000535057.1_Silent_p.K500K|C8B_ENST00000371237.4_Silent_p.K562K	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	562	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TTTGTCTTGTCTTACGTCTTC	0.463000													11	90					0	0	1	0	0
ASMTL	8623	broad.mit.edu	37	X	1540607	1540607	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:1540607C>T	ENST00000534940.1	-	9	1240	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K	ASMTL_ENST00000381333.4_Missense_Mutation_p.E381K|ASMTL_ENST00000381317.3_Missense_Mutation_p.E397K|ASMTL_ENST00000416733.2_Missense_Mutation_p.E321K	NM_001173473.1	NP_001166944.1	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	397	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(9)|pancreas(1)|soft_tissue(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTTGTTCCCTCTCGGATGGCA	0.532000													176	322					0	0	1	0	0
MIXL1	83881	broad.mit.edu	37	1	226413261	226413261	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:226413261C>G	ENST00000366810.5	+	2	511	c.447C>G	c.(445-447)ttC>ttG	p.F149L	MIXL1_ENST00000542034.1_Missense_Mutation_p.F157L|MIXL1_ENST00000557734.1_3'UTR			Q9H2W2	MIXL1_HUMAN	Mix paired-like homeobox	149					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.109)		GGAAATCCTTCCAACCTTTGG	0.493000													9	64					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12969354	12969354	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:12969354C>G	ENST00000251472.4	+	12	1206	c.1167C>G	c.(1165-1167)taC>taG	p.Y389*	MAST1_ENST00000591495.1_Nonsense_Mutation_p.Y385*	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	389	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.Y389Y(2)		NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						GCGCTGTCTACCTGGTGCGGC	0.667000													7	41					0	0	1	0	0
ISCA2	122961	broad.mit.edu	37	14	74961563	74961563	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:74961563G>A	ENST00000556816.1	+	4	380	c.325G>A	c.(325-327)Gac>Aac	p.D109N	ISCA2_ENST00000298818.8_Silent_p.*109*|ISCA2_ENST00000554924.1_3'UTR			Q86U28	ISCA2_HUMAN	iron-sulfur cluster assembly 2	109					iron-sulfur cluster assembly	mitochondrion	iron-sulfur cluster binding|metal ion binding|structural molecule activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00146)		AGTGGTGGTTGACTCTGATAG	0.502000													13	60					0	0	1	0	0
NUF2	83540	broad.mit.edu	37	1	163315524	163315524	+	Silent	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:163315524A>T	ENST00000271452.3	+	11	1143	c.864A>T	c.(862-864)tcA>tcT	p.S288S	NUF2_ENST00000524800.1_Intron|NUF2_ENST00000367900.3_Silent_p.S288S	NM_145697.2	NP_663735.2	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	288	Interaction with the N-terminus of NDC80.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	all_hematologic(923;0.101)					GCCTGCCTTCATGTCAGTTGG	0.363000													24	67					0	0	1	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643082	1643082	+	Missense_Mutation	SNP	T	T	C	rs59610171		TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:1643082T>C	ENST00000399682.1	-	1	286	c.242A>G	c.(241-243)tAt>tGt	p.Y81C		NM_001012709.1	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	81	9 X 4 AA repeats of C-C-X-P.					keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ACAAGAGCCATAGCCCCCCTT	0.657000													5	65					0	0	1	0	0
TGS1	96764	broad.mit.edu	37	8	56698426	56698426	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:56698426G>A	ENST00000260129.5	+	3	792	c.315G>A	c.(313-315)agG>agA	p.R105R		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	105					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			AATTTGGTAGGATAACTGCAC	0.343000													120	64					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179544404	179544404	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:179544404C>T	ENST00000589042.1	-	141	33810	c.33586G>A	c.(33586-33588)Gag>Aag	p.E11196K	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E10879K|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E9952K|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10879	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGGTACCTCAGGCACTTTA	0.388000													3	21					0	0	1	0	0
SETD4	54093	broad.mit.edu	37	21	37410549	37410549	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:37410549G>A	ENST00000399215.1	-	9	2459	c.1087C>T	c.(1087-1089)Ctt>Ttt	p.L363F	SETD4_ENST00000399212.1_Missense_Mutation_p.L339F|SETD4_ENST00000481477.1_5'UTR|AP000688.1_ENST00000600312.1_Intron|SETD4_ENST00000332131.4_Missense_Mutation_p.L363F			Q9NVD3	SETD4_HUMAN	SET domain containing 4	363				EILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRL LTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKI CYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTEELK ILRASAETLHSLQTAFT -> GWNQLCS (in Ref. 5; AAH02898).						autonomic_ganglia(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	15						ACCTCCCCAAGAAGTACTTTT	0.348000													15	123					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91690591	91690591	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:91690591G>A	ENST00000359028.2	+	24	5880	c.5655G>A	c.(5653-5655)gtG>gtA	p.V1885V	AKAP9_ENST00000358100.2_Silent_p.V1885V|AKAP9_ENST00000491695.1_3'UTR|AKAP9_ENST00000356239.3_Silent_p.V1873V			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1885	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ATGCGAAAGTGACACAGACAG	0.398000			T	BRAF	papillary thyroid								6	50					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82583524	82583524	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:82583524G>A	ENST00000333891.9	-	5	7082	c.6745C>T	c.(6745-6747)Cgg>Tgg	p.R2249W	PCLO_ENST00000423517.2_Missense_Mutation_p.R2249W	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGGGCAGTCCGATCTAAAGAT	0.358000													10	25					0	0	1	0	0
GLI4	2738	broad.mit.edu	37	8	144358776	144358776	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:144358776C>T	ENST00000340042.1	+	4	1018	c.933C>T	c.(931-933)atC>atT	p.I311I	GLI4_ENST00000523812.1_3'UTR|GLI4_ENST00000523522.1_Silent_p.I311I	NM_138465.3	NP_612474.1	P10075	GLI4_HUMAN	GLI family zinc finger 4	311						nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(1)|lung(5)	9	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CCGTGCTCATCGAGCACCAGC	0.667000													7	34					0	0	1	0	0
PPP2R3C	55012	broad.mit.edu	37	14	35577384	35577384	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:35577384T>G	ENST00000261475.5	-	5	816	c.463A>C	c.(463-465)Att>Ctt	p.I155L	PPP2R3C_ENST00000555644.1_Missense_Mutation_p.I155L	NM_017917.2	NP_060387.2	Q969Q6	P2R3C_HUMAN	protein phosphatase 2, regulatory subunit B'', gamma	155						centrosome|nucleus	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)	15	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)		ATGATGGAAATTCTTCCATAT	0.323000													4	93					0	0	1	0	0
INSM2	84684	broad.mit.edu	37	14	36003676	36003676	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:36003676C>T	ENST00000307169.3	+	1	429	c.218C>T	c.(217-219)tCg>tTg	p.S73L		NM_032594.3	NP_115983.3	Q96T92	INSM2_HUMAN	insulinoma-associated 2	73					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	10	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		CGGGAACAGTCGGGGTCGCCA	0.781000													2	2					0	0	1	0	0
GET4	51608	broad.mit.edu	37	7	935027	935027	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:935027C>T	ENST00000407192.1	+	8	3310	c.793C>T	c.(793-795)Ccc>Tcc	p.P265S	GET4_ENST00000265857.3_Missense_Mutation_p.P318S			Q7L5D6	GET4_HUMAN	golgi to ER traffic protein 4 homolog (S. cerevisiae)	318					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding			breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GGAGGAGAGCCCCAGCGACGG	0.652000													6	41					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54555737	54555737	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:54555737C>T	ENST00000251636.5	-	26	4144	c.3996G>A	c.(3994-3996)ctG>ctA	p.L1332L	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	1332							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TGAGAACTCTCAGCTGCTTGA	0.358000													4	48					0	0	1	0	0
YTHDC2	64848	broad.mit.edu	37	5	112901603	112901603	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:112901603C>A	ENST00000161863.4	+	21	2942	c.2729C>A	c.(2728-2730)gCa>gAa	p.A910E		NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	910							ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TGGCAAAAAGCACGAAGTGAT	0.388000													8	36					1.06961e-07	1.10553e-07	1	1	0
RPS6KA2	6196	broad.mit.edu	37	6	166831715	166831715	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:166831715T>C	ENST00000510118.1	-	21	2351	c.2011A>G	c.(2011-2013)Aaa>Gaa	p.K671E	RPS6KA2_ENST00000481261.2_Missense_Mutation_p.K557E|RPS6KA2_ENST00000503859.1_Missense_Mutation_p.K654E|RPS6KA2_ENST00000405189.3_Missense_Mutation_p.K557E|RPS6KA2_ENST00000509742.1_5'UTR|RPS6KA2_ENST00000265678.4_Missense_Mutation_p.K646E			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	646	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		GTACTCACTTTAGCTGCGTCA	0.468000													8	88					0	0	1	0	0
FAM154A	158297	broad.mit.edu	37	9	18941669	18941669	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:18941669A>G	ENST00000380534.4	-	3	666	c.387T>C	c.(385-387)tgT>tgC	p.C129C	FAM154A_ENST00000380530.1_Intron|FAM154A_ENST00000542071.1_Intron	NM_153707.2	NP_714918.2	Q8IYX7	F154A_HUMAN	family with sequence similarity 154, member A	129										breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|skin(1)	26				GBM - Glioblastoma multiforme(50;6.53e-16)		TCTTGTCGCTACATGGATATT	0.493000													3	70					0	0	1	0	0
PRLHR	2834	broad.mit.edu	37	10	120354632	120354632	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:120354632G>A	ENST00000239032.2	-	2	263	c.125C>T	c.(124-126)gCg>gTg	p.A42V	PRLHR_ENST00000369169.1_Missense_Mutation_p.A42V	NM_004248.2	NP_004239	P49683	PRLHR_HUMAN	prolactin releasing hormone receptor	42					female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity			large_intestine(2)|lung(8)|ovary(1)|skin(1)	12		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		TGGAGCGTCCGCGCCAGCCAC	0.672000													4	50					0	0	1	0	0
INTS6	26512	broad.mit.edu	37	13	51969472	51969472	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:51969472C>T	ENST00000311234.4	-	5	1049	c.577G>A	c.(577-579)Gac>Aac	p.D193N	INTS6_ENST00000420668.2_Intron|INTS6_ENST00000463928.1_Missense_Mutation_p.D193N|INTS6_ENST00000497989.1_Missense_Mutation_p.D15N|INTS6_ENST00000425000.1_5'UTR|INTS6_ENST00000398119.2_Missense_Mutation_p.D180N	NM_012141.2	NP_036273.1	Q9UL03	INT6_HUMAN	integrator complex subunit 6	193	VWFA.				snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		ATTGCAGAGTCATCTAAAGGC	0.418000													17	135					0	0	1	0	0
C12orf39	80763	broad.mit.edu	37	12	21681967	21681967	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:21681967A>T	ENST00000256969.2	+	5	407	c.241A>T	c.(241-243)Att>Ttt	p.I81F	C12orf39_ENST00000543800.1_3'UTR	NM_030572.2	NP_085049.1	Q9BT56	SPXN_HUMAN	chromosome 12 open reading frame 39	81						extracellular region|nucleus|transport vesicle				endometrium(3)|large_intestine(1)|lung(2)|urinary_tract(1)	7						ACTACTAACTATTCCGGAGGC	0.408000													18	124					0	0	1	0	0
WLS	79971	broad.mit.edu	37	1	68624818	68624818	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:68624818G>A	ENST00000262348.4	-	3	745	c.492C>T	c.(490-492)ttC>ttT	p.F164F	WLS_ENST00000370976.3_Silent_p.F73F|WLS_ENST00000354777.2_Silent_p.F162F|GNG12-AS1_ENST00000413628.1_RNA|GNG12-AS1_ENST00000420587.1_RNA|WLS_ENST00000540432.1_Silent_p.F164F	NM_024911.6	NP_079187.3	Q5T9L3	WLS_HUMAN	wntless Wnt ligand secretion mediator	164	Interacts with Wnt proteins (By similarity).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(4)|prostate(3)|urinary_tract(1)	20						TGGGAGATGTGAAGGTGCATT	0.463000													11	88					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186056647	186056647	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:186056647C>T	ENST00000271588.4	+	60	9462	c.9233C>T	c.(9232-9234)tCt>tTt	p.S3078F	HMCN1_ENST00000367492.2_Missense_Mutation_p.S3078F	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3078	Ig-like C2-type 29.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ACTTCTGTGTCTTTGGAGTGT	0.433000													15	160					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71978157	71978157	+	Silent	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:71978157T>C	ENST00000266674.5	+	18	2678	c.2367T>C	c.(2365-2367)tcT>tcC	p.S789S	LGR5_ENST00000536515.1_Silent_p.S717S|LGR5_ENST00000540815.2_Silent_p.S765S			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	789						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						CCTTCTCCTCTTTAATAAACC	0.423000													6	191					0	0	1	0	0
SLC7A4	6545	broad.mit.edu	37	22	21384612	21384612	+	Silent	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:21384612G>C	ENST00000382932.2	-	3	1078	c.1011C>G	c.(1009-1011)ctC>ctG	p.L337L	SLC7A4_ENST00000403586.1_Silent_p.L337L	NM_004173.2	NP_004164.2	O43246	CTR4_HUMAN	solute carrier family 7, member 4	337					cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(2)	18	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GCAGGGAGAAGAGGAGGCTGA	0.647000													49	30					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32689742	32689742	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:32689742C>T	ENST00000421745.2	+	25	5241	c.5107C>T	c.(5107-5109)Ctt>Ttt	p.L1703F		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	1703					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					AACAACACCTCTTTTTATGAC	0.488000													6	51					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177250320	177250320	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:177250320G>A	ENST00000361539.4	+	8	2320	c.2008G>A	c.(2008-2010)Gat>Aat	p.D670N	BRINP2_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1			bone morphogenetic protein/retinoic acid inducible neural-specific 2	670																	GGAGATGACTGATCCCTCTAA	0.463000													31	75					0	0	1	0	0
MAP1LC3B	81631	broad.mit.edu	37	16	87435864	87435864	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:87435864G>A	ENST00000268607.5	+	3	808	c.180G>A	c.(178-180)atG>atA	p.M60I	MAP1LC3B_ENST00000534986.1_Start_Codon_SNP_p.M1I|MAP1LC3B_ENST00000565788.1_Missense_Mutation_p.M60I	NM_022818.4	NP_073729.1	Q9GZQ8	MLP3B_HUMAN	microtubule-associated protein 1 light chain 3 beta	60					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			endometrium(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(80;0.0249)		ATGTCAACATGAGTGAGCTCA	0.353000													8	40					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26906504	26906504	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:26906504C>G	ENST00000321765.5	-	18	3217		c.e18-1			NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5						cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					CCTGGGGTCTCTGAAAGAGAA	0.488000													10	83					0	0	1	0	0
OR5F1	338674	broad.mit.edu	37	11	55761855	55761855	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:55761855C>T	ENST00000278409.1	-	1	246	c.247G>A	c.(247-249)Gca>Aca	p.A83T		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A83P(1)		endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					AATAAATCTGCCAGCATCTTT	0.458000													6	55					0	0	1	0	0
CDC7	8317	broad.mit.edu	37	1	91978756	91978756	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:91978756G>A	ENST00000428239.1	+	7	973	c.714G>A	c.(712-714)ctG>ctA	p.L238L	CDC7_ENST00000430031.2_Silent_p.L210L|CDC7_ENST00000234626.6_Silent_p.L238L	NM_001134420.1	NP_001127892.1	O00311	CDC7_HUMAN	cell division cycle 7	238	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|stomach(2)	23		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		AGATTCCACTGAGTGGCCCAG	0.408000													7	51					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66941720	66941720	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:66941720G>C	ENST00000374690.3	+	6	2888	c.2364G>C	c.(2362-2364)atG>atC	p.M788I	AR_ENST00000396044.3_Intron|AR_ENST00000396043.2_Missense_Mutation_p.M256I	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	787	Interaction with MYST2.|Ligand-binding.		R -> S (in AIS).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	GTGTCCGAATGAGGCACCTCT	0.498000									Androgen Insensitivity Syndrome				13	40					0	0	1	0	0
NDUFC1	4717	broad.mit.edu	37	4	140216200	140216200	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:140216200G>A	ENST00000544855.1	-	4	997	c.168C>T	c.(166-168)atC>atT	p.I56I	NDUFC1_ENST00000539387.1_Silent_p.I56I|NDUFC1_ENST00000394223.1_Silent_p.I56I|NDUFC1_ENST00000394228.1_Silent_p.I56I|NDUFC1_ENST00000505036.1_Silent_p.I56I|NDUFC1_ENST00000265500.4_Silent_p.I56I|NDUFC1_ENST00000539002.1_Silent_p.I56I	NM_001184986.1	NP_001171915.1	O43677	NDUC1_HUMAN	NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa	56					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(1)|upper_aerodigestive_tract(1)	2	all_hematologic(180;0.162)				NADH(DB00157)	TACTTACATAGATCCACAAGA	0.478000													9	34					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151366256	151366256	+	Splice_Site	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:151366256T>C	ENST00000370314.4	-	8	1018	c.780A>G	c.(778-780)ggA>ggG	p.G260G	GABRA3_ENST00000535043.1_Splice_Site_p.G260G	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	260					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CGACATATTCTCCTAAAGAGA	0.383000													4	22					0	0	1	0	0
ZPBP	11055	broad.mit.edu	37	7	50023080	50023080	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:50023080T>A	ENST00000046087.2	-	7	888	c.819A>T	c.(817-819)caA>caT	p.Q273H	ZPBP_ENST00000419417.1_Missense_Mutation_p.Q272H|ZPBP_ENST00000491129.1_5'UTR	NM_001159878.1|NM_007009.2	NP_001153350.1|NP_008940.2	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein	273					binding of sperm to zona pellucida	extracellular region				NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(3)	29	Glioma(55;0.08)|all_neural(89;0.245)					GAATTTCTACTTGTTGATTAA	0.303000													18	24					0	0	1	0	0
GNPTAB	79158	broad.mit.edu	37	12	102147193	102147193	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:102147193C>T	ENST00000299314.7	-	19	3821	c.3559G>A	c.(3559-3561)Gag>Aag	p.E1187K		NM_024312.4	NP_077288.2	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	1187					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	37						TTTCGATACTCTCTTGGCAGT	0.413000													18	41					0	0	1	0	0
FLOT1	10211	broad.mit.edu	37	6	30698733	30698733	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:30698733C>T	ENST00000376389.3	-	9	1088	c.868G>A	c.(868-870)Gag>Aag	p.E290K	FLOT1_ENST00000456573.2_Missense_Mutation_p.E242K	NM_005803.2	NP_005794.1	O75955	FLOT1_HUMAN	flotillin 1	290						centriolar satellite|endosome|integral to membrane|melanosome|membrane fraction				breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|prostate(1)	13						TTGTAGCGCTCCGCTTCCGCT	0.667000													3	51					0	0	1	0	0
ATG14	22863	broad.mit.edu	37	14	55852747	55852747	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:55852747T>G	ENST00000247178.5	-	5	512	c.477A>C	c.(475-477)caA>caC	p.Q159H		NM_014924.4	NP_055739.2	Q6ZNE5	BAKOR_HUMAN	autophagy related 14	159					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						CCTTTTTCTCTTGGTGCCGTT	0.388000													7	71					0	0	1	0	0
LAT2	7462	broad.mit.edu	37	7	73634089	73634089	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:73634089G>A	ENST00000460943.1	+	5	1039	c.150G>A	c.(148-150)caG>caA	p.Q50Q	LAT2_ENST00000398475.1_Silent_p.Q50Q|LAT2_ENST00000344995.5_Silent_p.Q50Q|LAT2_ENST00000275635.7_Silent_p.Q50Q	NM_032464.2	NP_115853.2	Q9GZY6	NTAL_HUMAN	linker for activation of T cells family, member 2	50					B cell activation|B cell receptor signaling pathway|calcium-mediated signaling|mast cell degranulation	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	6						AGGACCAACAGAGCTTTACGG	0.612000													20	132					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111052137	111052137	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:111052137G>A	ENST00000551590.1	+	1	306	c.150G>A	c.(148-150)tcG>tcA	p.S50S	TCTN1_ENST00000397659.4_Silent_p.S50S|TCTN1_ENST00000471804.2_Silent_p.S50S|TCTN1_ENST00000397655.3_Silent_p.S50S|TCTN1_ENST00000377654.3_5'UTR|TCTN1_ENST00000550703.2_Silent_p.S50S			Q2MV58	TECT1_HUMAN	tectonic family member 1	50					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						CTTTCCCGTCGACCAGGCCCC	0.716000													4	5					0	0	1	0	0
LPPR5	163404	broad.mit.edu	37	1	99470138	99470138	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:99470138G>A	ENST00000370188.3	-	1	450	c.90C>T	c.(88-90)ttC>ttT	p.F30F	LPPR5_ENST00000263177.4_Silent_p.F30F|RP5-896L10.1_ENST00000425113.1_RNA	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		30						integral to membrane	hydrolase activity										CCGTATACTCGAAGTAGTACG	0.637000													19	65					0	0	1	0	0
RNF19A	25897	broad.mit.edu	37	8	101271100	101271100	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:101271100G>C	ENST00000519449.1	-	11	2517	c.2201C>G	c.(2200-2202)tCt>tGt	p.S734C	RNF19A_ENST00000341084.2_Missense_Mutation_p.S734C	NM_001280539.1|NM_015435.3	NP_001267468.1|NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	734	Interaction with CASR.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			TTCTAGGTCAGAACAACTAAA	0.413000											OREG0018897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	93	118					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32776563	32776563	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:32776563G>A	ENST00000380250.3	+	31	4413	c.3917G>A	c.(3916-3918)gGa>gAa	p.G1306E		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ATTCTCTATGGAACACACGGC	0.483000													10	102					0	0	1	0	0
FAM209B	388799	broad.mit.edu	37	20	55108525	55108525	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:55108525G>A	ENST00000371325.1	+	1	224	c.128G>A	c.(127-129)cGg>cAg	p.R43Q		NM_001013646.2	NP_001013668.2	Q5JX69	CT107_HUMAN	family with sequence similarity 209, member B	43						integral to membrane											GAGCACTTTCGGATTCGGCAG	0.527000													34	112					0	0	1	0	0
CCDC86	79080	broad.mit.edu	37	11	60610027	60610027	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:60610027G>A	ENST00000227520.5	+	1	484	c.430G>A	c.(430-432)Gag>Aag	p.E144K	RP11-804A23.2_ENST00000539897.1_RNA|RP11-804A23.4_ENST00000538705.1_RNA	NM_024098.3	NP_077003.1	Q9H6F5	CCD86_HUMAN	coiled-coil domain containing 86	144	Pro-rich.				interspecies interaction between organisms	nucleus				endometrium(1)|large_intestine(2)|liver(2)|lung(2)|urinary_tract(3)	10						GAATAAGGAGGAGCTGACCCC	0.642000													4	37					0	0	1	0	0
COG1	9382	broad.mit.edu	37	17	71193179	71193179	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:71193179G>C	ENST00000299886.4	+	3	781	c.701G>C	c.(700-702)aGa>aCa	p.R234T		NM_018714.2	NP_061184.1	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	234					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18			LUSC - Lung squamous cell carcinoma(166;0.197)			CTGCTGGCCAGAAAGGCAACT	0.522000													9	68					0	0	1	0	0
VHL	7428	broad.mit.edu	37	3	10183798	10183798	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:10183798C>T	ENST00000256474.2	+	1	1107	c.267C>T	c.(265-267)ctC>ctT	p.L89L	VHL_ENST00000345392.2_Silent_p.L89L	NM_000551.3	NP_000542.1	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	89			L -> H (in lung cancer).|L -> P (in VHLD; type I; dbSNP:rs5030807).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.R60fs*35(1)|p.L89fs*67(1)|p.V84fs*69(1)|p.V84_E94>E(1)		adrenal_gland(25)|autonomic_ganglia(3)|central_nervous_system(2)|endometrium(6)|kidney(1662)|large_intestine(14)|lung(6)|pancreas(18)|paratesticular_tissues(1)|pleura(1)|skin(1)|soft_tissue(24)|thyroid(3)|upper_aerodigestive_tract(3)	1769				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		CCGTATGGCTCAACTTCGACG	0.726000		1	"""D, Mis, N, F, S"""		"""renal, hemangioma, pheochromocytoma"""	"""renal, hemangioma, pheochromocytoma"""			von Hippel-Lindau disease;Pheochromocytoma (Adrenal), Familial;Chuvash Polycythemia				6	11					0	0	1	0	0
MAPK6	5597	broad.mit.edu	37	15	52356937	52356937	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:52356937A>G	ENST00000261845.5	+	6	2713	c.1906A>G	c.(1906-1908)Aaa>Gaa	p.K636E	CTD-2184D3.5_ENST00000558607.1_RNA	NM_002748.3	NP_002739.1	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	636					cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		CTTTAGCAGGAAAGAAGATAC	0.418000													18	51					0	0	1	0	0
OR10J5	127385	broad.mit.edu	37	1	159505031	159505031	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:159505031A>G	ENST00000334857.2	-	1	811	c.767T>C	c.(766-768)aTt>aCt	p.I256T		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					GAGGTAGGCAATGGAGGCACA	0.498000													27	47					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197404441	197404441	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:197404441C>A	ENST00000367397.1	+	5	2449	c.1591C>A	c.(1591-1593)Cat>Aat	p.H531N	CRB1_ENST00000544212.1_Missense_Mutation_p.H631N|CRB1_ENST00000367400.3_Missense_Mutation_p.H1150N|CRB1_ENST00000535699.1_Missense_Mutation_p.H1126N|CRB1_ENST00000367399.2_Missense_Mutation_p.H1038N|CRB1_ENST00000538660.1_Intron			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1150	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CCCCTGTTTGCATGGAGGAAA	0.428000													28	33					7.41945e-09	7.69666e-09	1	1	0
CHST13	166012	broad.mit.edu	37	3	126260860	126260860	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:126260860C>T	ENST00000319340.2	+	3	515	c.465C>T	c.(463-465)ttC>ttT	p.F155F		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	155					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		TGGCCGACTTCAGCCCCGCCG	0.726000													3	16					0	0	1	0	0
AMOTL2	51421	broad.mit.edu	37	3	134078274	134078274	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:134078274C>G	ENST00000514516.1	-	8	2307	c.2129G>C	c.(2128-2130)aGa>aCa	p.R710T	AMOTL2_ENST00000249883.5_Missense_Mutation_p.R652T|AMOTL2_ENST00000422605.2_Missense_Mutation_p.R652T|AMOTL2_ENST00000513145.1_Missense_Mutation_p.R650T	NM_001278683.1	NP_001265612.1	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	652										endometrium(8)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	19						GCCAGGGTCTCTCCTGGAGCG	0.627000													7	17					0	0	1	0	0
DISC1	27185	broad.mit.edu	37	1	231954112	231954112	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:231954112G>T	ENST00000439617.2	+	9	1883	c.1830G>T	c.(1828-1830)gaG>gaT	p.E610D	DISC1_ENST00000535983.1_Missense_Mutation_p.E610D|DISC1_ENST00000602281.1_Missense_Mutation_p.E610D|DISC1_ENST00000366637.3_5'UTR|TSNAX-DISC1_ENST00000602962.1_3'UTR|DISC1_ENST00000537876.1_Intron|DISC1_ENST00000366636.4_Missense_Mutation_p.E610D|DISC1_ENST00000602873.1_3'UTR|DISC1_ENST00000366633.3_Missense_Mutation_p.E610D|DISC1_ENST00000539444.1_Missense_Mutation_p.R576I	NM_001164537.1|NM_001164540.1|NM_018662.2	NP_001158009.1|NP_001158012.1|NP_061132.2	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1	610	Interaction with ATF4 and ATF5.|Interaction with TRAF3IP1.|Necessary and sufficient for interaction with PCNT and localization at the centrosome.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			breast(1)|cervix(1)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(173;0.0208)|Prostate(94;0.0975)				TCACCGAGGAGATTAGATCAT	0.473000													4	57					0.00198382	0.00201224	1	1	0
TIGIT	201633	broad.mit.edu	37	3	114026866	114026866	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:114026866C>T	ENST00000481065.1	+	5	3439	c.824C>T	c.(823-825)gCt>gTt	p.A275V	TIGIT_ENST00000383671.3_Missense_Mutation_p.A208V|TIGIT_ENST00000486257.1_Missense_Mutation_p.A208V|TIGIT_ENST00000496848.1_3'UTR			Q495A1	TIGIT_HUMAN	T cell immunoreceptor with Ig and ITIM domains	208					negative regulation of interleukin-12 production|negative regulation of T cell activation|positive regulation of interleukin-10 production	cell surface|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(7)|prostate(1)	17						GCTGCACCTGCTGGGCTCTGT	0.577000													27	113					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158368903	158368903	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:158368903C>T	ENST00000334438.1	-	1	353	c.354G>A	c.(352-354)gtG>gtA	p.V118V		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					CATATCCCATCACAGCAATGA	0.493000													21	73					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45750897	45750897	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr22:45750897G>A	ENST00000357450.4	-	20	3059	c.3060C>T	c.(3058-3060)aaC>aaT	p.N1020N	SMC1B_ENST00000404354.3_Silent_p.N1020N	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	1020					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GTGCTCGTAGGTTTGGGGCTG	0.433000													16	92					0	0	1	0	0
CASC1	55259	broad.mit.edu	37	12	25272112	25272112	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:25272112C>T	ENST00000354189.5	-	12	1572	c.1537G>A	c.(1537-1539)Gag>Aag	p.E513K	CASC1_ENST00000545133.1_Missense_Mutation_p.E390K|CASC1_ENST00000395990.2_Missense_Mutation_p.E409K|CASC1_ENST00000395987.3_Missense_Mutation_p.E455K|CASC1_ENST00000537577.1_Missense_Mutation_p.E337K|CASC1_ENST00000557684.1_5'UTR|CASC1_ENST00000320267.9_Missense_Mutation_p.E449K	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	449										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			ACAGGATCCTCAAAAAAGATT	0.368000													6	47					0	0	1	0	0
RPS27	6232	broad.mit.edu	37	1	153964055	153964055	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:153964055C>T	ENST00000368567.4	+	3	167	c.129C>T	c.(127-129)atC>atT	p.I43I	RPS27_ENST00000392558.4_3'UTR|RPS27_ENST00000493224.1_3'UTR	NM_001030.4	NP_001021.1	P42677	RS27_HUMAN	ribosomal protein S27	43					cell proliferation|endocrine pancreas development|mitotic prometaphase|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleus	DNA binding|structural constituent of ribosome|zinc ion binding			kidney(1)	1	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCTATAAAATCACCACGGTCT	0.433000													12	61					0	0	1	0	0
CBLN4	140689	broad.mit.edu	37	20	54579153	54579153	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:54579153G>A	ENST00000064571.2	-	1	1375	c.75C>T	c.(73-75)gtC>gtT	p.V25V		NM_080617.5	NP_542184.1	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	25						cell junction|extracellular region|synapse				endometrium(2)|large_intestine(1)|lung(10)|ovary(3)|pancreas(1)	17			Colorectal(105;0.202)			TCTGTGCCCAGACGGGCAGCC	0.721000													3	15					0	0	1	0	0
GPATCH2	55105	broad.mit.edu	37	1	217793681	217793681	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:217793681G>A	ENST00000366935.3	-	2	327	c.217C>T	c.(217-219)Cgg>Tgg	p.R73W	GPATCH2_ENST00000366934.3_Missense_Mutation_p.R73W	NM_018040.2	NP_060510.1	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	73						intracellular	nucleic acid binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)	35				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		TACGACCTCCGTTTTCTCCCT	0.478000													8	86					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158224897	158224897	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:158224897C>T	ENST00000289429.5	+	2	615	c.82C>T	c.(82-84)Cat>Tat	p.H28Y		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	28					antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	TCTCTCCTTCCATGTCACCTG	0.488000													17	120					0	0	1	0	0
PLOD2	5352	broad.mit.edu	37	3	145828198	145828198	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:145828198G>A	ENST00000282903.5	-	4	553	c.376C>T	c.(376-378)Cta>Tta	p.L126L	PLOD2_ENST00000360060.3_Silent_p.L126L|PLOD2_ENST00000494950.1_Silent_p.L71L	NM_182943.2	NP_891988.1	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	126					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29					Vitamin C(DB00126)	AATTTTTTTAGAACTTCTTCT	0.373000													8	76					0	0	1	0	0
TTLL7	79739	broad.mit.edu	37	1	84383298	84383298	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:84383298G>C	ENST00000260505.8	-	14	1953	c.1576C>G	c.(1576-1578)Cga>Gga	p.R526G	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	526					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity	p.R526*(1)		kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TTTGGTCCTCGAGTCTTGGTA	0.353000													5	41					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7583909	7583909	+	Silent	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:7583909G>C	ENST00000379802.3	+	24	6755	c.6414G>C	c.(6412-6414)gtG>gtC	p.V2138V	DSP_ENST00000418664.2_Silent_p.V1539V	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2138	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TAGACCCTGTGAACAGTGTCT	0.463000													8	55					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129218907	129218907	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:129218907G>A	ENST00000296266.3	+	20	2716	c.2524G>A	c.(2524-2526)Gac>Aac	p.D842N	IFT122_ENST00000507564.1_Missense_Mutation_p.D783N|IFT122_ENST00000440957.2_Missense_Mutation_p.D582N|IFT122_ENST00000348417.2_Missense_Mutation_p.D791N|IFT122_ENST00000504021.1_Missense_Mutation_p.D667N|IFT122_ENST00000513932.1_3'UTR|IFT122_ENST00000347300.2_Missense_Mutation_p.D732N|IFT122_ENST00000431818.2_Missense_Mutation_p.D641N|IFT122_ENST00000349441.2_Missense_Mutation_p.D680N	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	791					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TGGCTGGGTTGACATGTAGGT	0.507000													4	58					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160869829	160869829	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:160869829C>G	ENST00000283243.7	-	10	1815	c.1609G>C	c.(1609-1611)Gac>Cac	p.D537H	PLA2R1_ENST00000392771.1_Missense_Mutation_p.D537H	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	537	C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GAAGCTTGGTCAAAGCTTCGA	0.373000													5	36					0	0	1	0	0
ZNF644	84146	broad.mit.edu	37	1	91405617	91405617	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:91405617G>A	ENST00000370440.1	-	3	1511	c.1294C>T	c.(1294-1296)Cat>Tat	p.H432Y	ZNF644_ENST00000361321.5_Intron|ZNF644_ENST00000347275.5_Intron|ZNF644_ENST00000337393.5_Missense_Mutation_p.H432Y|ZNF644_ENST00000467231.1_Intron			Q9H582	ZN644_HUMAN	zinc finger protein 644	432					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		CCATCTAAATGATACATCATA	0.428000													17	68					0	0	1	0	0
SKIV2L	6499	broad.mit.edu	37	6	31935772	31935772	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:31935772A>G	ENST00000375394.2	+	23	2884	c.2771A>G	c.(2770-2772)gAt>gGt	p.D924G	SKIV2L_ENST00000544581.1_Missense_Mutation_p.D731G	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	924						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						CAGCCAGGAGATATGGCTGCC	0.552000													4	21					0	0	1	0	0
DSPP	1834	broad.mit.edu	37	4	88533735	88533735	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:88533735G>A	ENST00000399271.1	+	4	517	c.397G>A	c.(397-399)Gca>Aca	p.A133T	DSPP_ENST00000282478.7_Missense_Mutation_p.A133T|RP11-742B18.1_ENST00000506480.1_RNA	NM_014208.3	NP_055023.2	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein	133					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		AAACATCACAGCAAATGGCAT	0.428000													3	33					0	0	1	0	0
SPTLC2	9517	broad.mit.edu	37	14	78063531	78063531	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:78063531T>C	ENST00000216484.2	-	2	518	c.325A>G	c.(325-327)Aag>Gag	p.K109E		NM_004863.3	NP_004854.1	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base subunit 2	109						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(5)	19			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ACAGTTACCTTTTGTTCTTCT	0.363000													8	28					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170027067	170027067	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:170027067C>T	ENST00000263816.3	-	59	11659	c.11374G>A	c.(11374-11376)Gac>Aac	p.D3792N		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3792	LDL-receptor class A 32.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTACCACAGTCCCGTTCATCT	0.438000													13	109					0	0	1	0	0
ARMCX2	9823	broad.mit.edu	37	X	100912204	100912204	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:100912204C>T	ENST00000328766.5	-	5	824	c.371G>A	c.(370-372)gGg>gAg	p.G124E	ARMCX2_ENST00000356824.4_Missense_Mutation_p.G124E|ARMCX2_ENST00000330154.2_Missense_Mutation_p.G124E	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	124	Ala-rich.					integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						GGCCTTAGGCCCAACCCCGGC	0.637000													18	33					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129634146	129634146	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:129634146C>T	ENST00000421865.2	+	23	3364	c.3315C>T	c.(3313-3315)ctC>ctT	p.L1105L		NM_000426.3|NM_001079823.1	NP_000417|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1105	Laminin EGF-like 12.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCTGCAATCTCTGTGACTGCT	0.468000													11	61					0	0	1	0	0
TRMT44	152992	broad.mit.edu	37	4	8465793	8465793	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:8465793C>T	ENST00000389737.4	+	7	1285	c.1285C>T	c.(1285-1287)Cca>Tca	p.P429S	TRMT44_ENST00000513449.2_Missense_Mutation_p.P188S	NM_152544.2	NP_689757.2			tRNA methyltransferase 44 homolog (S. cerevisiae)																		TGAACTCACACCATGGATACC	0.428000													18	68					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67314896	67314896	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:67314896G>A	ENST00000360461.5	+	3	3242	c.707G>A	c.(706-708)cGa>cAa	p.R236Q	PLEKHG4_ENST00000379344.3_Missense_Mutation_p.R236Q|PLEKHG4_ENST00000450733.1_Missense_Mutation_p.R155Q|PLEKHG4_ENST00000427155.2_Missense_Mutation_p.R236Q	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	236					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		CTGTACCTGCGAAGCATCCCC	0.617000													8	35					0	0	1	0	0
TSC22D2	9819	broad.mit.edu	37	3	150127517	150127517	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:150127517C>T	ENST00000361875.3	+	1	1396	c.380C>T	c.(379-381)tCg>tTg	p.S127L	TSC22D2_ENST00000361136.2_Missense_Mutation_p.S127L	NM_014779.2	NP_055594.1	O75157	T22D2_HUMAN	TSC22 domain family, member 2								sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	18			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GCTGCCACTTCGGCCCCCGCC	0.741000													6	20					0	0	1	0	0
PPP4R1	9989	broad.mit.edu	37	18	9547888	9547888	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:9547888G>A	ENST00000400556.3	-	20	2825	c.2752C>T	c.(2752-2754)Cag>Tag	p.Q918*	PPP4R1_ENST00000400555.3_Nonsense_Mutation_p.Q901*	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	918					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			large_intestine(1)|skin(2)	3						CGGTCCATCTGAAGAGCCATG	0.512000													6	46					0	0	1	0	0
CCDC36	339834	broad.mit.edu	37	3	49294356	49294356	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:49294356C>T	ENST00000438782.1	+	8	1662	c.1426C>T	c.(1426-1428)Cag>Tag	p.Q476*	CCDC36_ENST00000452691.2_Nonsense_Mutation_p.Q476*|CCDC36_ENST00000296449.5_Nonsense_Mutation_p.Q476*			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	476										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		TTCCAAATATCAGAGTCCTCA	0.567000													33	237					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29445420	29445420	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:29445420A>T	ENST00000389048.3	-	21	4319	c.3413T>A	c.(3412-3414)aTg>aAg	p.M1138K	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1138	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GTCGTTGGGCATTCCGGACAC	0.577000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				5	27					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141591909	141591909	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:141591909C>G	ENST00000442267.2	-	7	1305	c.1231G>C	c.(1231-1233)Gag>Cag	p.E411Q		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	411						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CCTGCAAACTCCTTGTCAGAA	0.413000													8	39					0	0	1	0	0
OR5K2	402135	broad.mit.edu	37	3	98216951	98216951	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:98216951C>A	ENST00000427338.1	+	1	504	c.427C>A	c.(427-429)Cag>Aag	p.Q143K	CLDND1_ENST00000502288.1_3'UTR	NM_001004737.1	NP_001004737.1	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K, member 2	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						ACTCTGCATTCAGATGACCAC	0.468000													5	137					0.014758	0.014863	1	1	0
SRSF4	6429	broad.mit.edu	37	1	29475156	29475156	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:29475156A>G	ENST00000373795.4	-	6	1485	c.1251T>C	c.(1249-1251)caT>caC	p.H417H	SRSF4_ENST00000546138.1_3'UTR	NM_005626.4	NP_005617.2	Q08170	SRSF4_HUMAN	serine/arginine-rich splicing factor 4	417	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(1)	27						CAGACTTGGCATGTTCCCGCT	0.562000													55	158					0	0	1	0	0
GTF2I	2969	broad.mit.edu	37	7	74148296	74148296	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:74148296T>G	ENST00000324896.4	+	16	1725	c.1336T>G	c.(1336-1338)Tta>Gta	p.L446V	GTF2I_ENST00000346152.4_Missense_Mutation_p.L425V|GTF2I_ENST00000353920.4_Missense_Mutation_p.L426V|GTF2I_ENST00000416070.1_Missense_Mutation_p.L405V	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi	446					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						ACGTGAAGATTTACAGCTTGA	0.358000													19	94					0	0	1	0	0
HAGH	3029	broad.mit.edu	37	16	1872916	1872916	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:1872916C>T	ENST00000397356.3	-	2	605	c.199G>A	c.(199-201)Gat>Aat	p.D67N	HAGH_ENST00000397353.2_Missense_Mutation_p.D19N|HAGH_ENST00000566709.1_Missense_Mutation_p.D19N|HAGH_ENST00000455446.2_Missense_Mutation_p.D67N	NM_005326.4	NP_005317.2	Q16775	GLO2_HUMAN	hydroxyacylglutathione hydrolase	67					glutathione biosynthetic process	cytoplasm|mitochondrial matrix	hydroxyacylglutathione hydrolase activity|zinc ion binding			kidney(2)|lung(1)|ovary(1)|skin(1)	5		Hepatocellular(780;0.00335)			Glutathione(DB00143)	GTCTCATCATCAATGACCAGG	0.602000													8	56					0	0	1	0	0
OSBPL6	114880	broad.mit.edu	37	2	179247808	179247808	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:179247808C>G	ENST00000190611.4	+	17	2055	c.1679C>G	c.(1678-1680)cCa>cGa	p.P560R	OSBPL6_ENST00000359685.3_Missense_Mutation_p.P524R|OSBPL6_ENST00000409631.1_Missense_Mutation_p.P524R|OSBPL6_ENST00000392505.2_Missense_Mutation_p.P585R|OSBPL6_ENST00000315022.2_Missense_Mutation_p.P564R|OSBPL6_ENST00000409045.3_Missense_Mutation_p.P529R	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	560					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			GCATGCCTGCCAGCTCCTTGT	0.498000													12	67					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98744709	98744709	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:98744709C>G	ENST00000477737.1	+	6	914	c.710C>G	c.(709-711)tCc>tGc	p.S237C	VWA3B_ENST00000435344.1_Missense_Mutation_p.S237C|VWA3B_ENST00000451075.2_Missense_Mutation_p.S87C	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	237										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CAGATTGAATCCATTTACTAC	0.478000													10	90					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1279595	1279595	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:1279595G>A	ENST00000447027.1	+	43	16658	c.16600G>A	c.(16600-16602)Ggg>Agg	p.G5534R	MUC5B_ENST00000529681.1_Missense_Mutation_p.G5531R			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	5531	VWFC 3.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACCTTCTACGGGGTAAGGGC	0.617000													3	21					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82785627	82785627	+	Silent	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:82785627G>C	ENST00000333891.9	-	2	667	c.330C>G	c.(328-330)ctC>ctG	p.L110L	PCLO_ENST00000423517.2_Silent_p.L110L	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TACTTTTACTGAGACCAGGTT	0.448000													7	21					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209190135	209190135	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:209190135A>T	ENST00000264380.4	+	20	2758	c.2600A>T	c.(2599-2601)cAa>cTa	p.Q867L		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	867					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						TATCATTCTCAACTAGAAATA	0.433000													7	67					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160050855	160050855	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:160050855C>T	ENST00000263635.6	+	17	3067	c.2830C>T	c.(2830-2832)Cac>Tac	p.H944Y	TANC1_ENST00000454300.1_Missense_Mutation_p.H838Y	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	944						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						CGTCCAGTCTCACCTTGGCCA	0.552000													12	65					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64597298	64597298	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:64597298G>A	ENST00000342711.5	-	30	3611	c.3612C>T	c.(3610-3612)ctC>ctT	p.L1204L		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1204	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						GCTGGTAGCAGAGCACCTGGC	0.711000													6	6					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42932319	42932319	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:42932319A>G	ENST00000426333.2	-	21	2396	c.2099T>C	c.(2098-2100)aTa>aCa	p.I700T	EFTUD2_ENST00000591382.1_Missense_Mutation_p.I700T|EFTUD2_ENST00000592576.1_Missense_Mutation_p.I690T|EFTUD2_ENST00000402521.3_Missense_Mutation_p.I665T	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	700						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				CTCATTCTCTATGTCCTCTGC	0.537000													25	41					0	0	1	0	0
CHDH	55349	broad.mit.edu	37	3	53856611	53856611	+	Silent	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:53856611G>C	ENST00000315251.6	-	4	1199	c.762C>G	c.(760-762)ctC>ctG	p.L254L		NM_018397.4	NP_060867.2	Q8NE62	CHDH_HUMAN	choline dehydrogenase						alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	CCTCGGCCTTGAGGTTGGTGC	0.642000													4	29					0	0	1	0	0
NCEH1	57552	broad.mit.edu	37	3	172353764	172353764	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:172353764C>T	ENST00000475381.1	-	4	784	c.551G>A	c.(550-552)aGa>aAa	p.R184K	NCEH1_ENST00000538775.1_Missense_Mutation_p.R224K|NCEH1_ENST00000273512.3_Missense_Mutation_p.R216K|NCEH1_ENST00000543711.1_Missense_Mutation_p.R51K			Q6PIU2	NCEH1_HUMAN	neutral cholesterol ester hydrolase 1	184					lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)	15						AATGCAAATTCTGCCTGGATC	0.468000													13	84					0	0	1	0	0
CHD1L	9557	broad.mit.edu	37	1	146763168	146763168	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:146763168G>A	ENST00000369258.4	+	20	2345	c.2325G>A	c.(2323-2325)ctG>ctA	p.L775L	CHD1L_ENST00000467213.1_3'UTR|CHD1L_ENST00000431239.1_Silent_p.L681L|CHD1L_ENST00000369259.3_Silent_p.L571L|CHD1L_ENST00000361293.5_Silent_p.L494L	NM_001256336.1|NM_004284.4|NM_024568.2	NP_001243265.1|NP_004275.4|NP_078844.2	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein 1-like	775	Macro.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(923;0.0487)					CCTCAGACCTGAGTTTGGGAG	0.393000													11	71					0	0	1	0	0
PSMA2	5683	broad.mit.edu	37	7	42957400	42957400	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:42957400G>A	ENST00000442788.1	-	7	580	c.565C>T	c.(565-567)Cat>Tat	p.H189Y	PSMA2_ENST00000223321.4_Missense_Mutation_p.H189Y|PSMA2_ENST00000445517.1_Missense_Mutation_p.H119Y			P25787	PSA2_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 2	189					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|response to virus|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(2)	10						ATGGCTGTATGAATGGCATCT	0.279000													6	80					0	0	1	0	0
ZDHHC16	84287	broad.mit.edu	37	10	99216591	99216591	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:99216591G>A	ENST00000393760.1	+	12	1426	c.1077G>A	c.(1075-1077)atG>atA	p.M359I	ZDHHC16_ENST00000495735.1_3'UTR|ZDHHC16_ENST00000345745.5_Missense_Mutation_p.M278I|ZDHHC16_ENST00000370842.2_Missense_Mutation_p.M343I|ZDHHC16_ENST00000370854.3_Missense_Mutation_p.M359I|ZDHHC16_ENST00000352634.4_Missense_Mutation_p.M343I|ZDHHC16_ENST00000353979.3_Missense_Mutation_p.M320I|ZDHHC16_ENST00000370846.4_Missense_Mutation_p.M289I	NM_198046.1	NP_932163.1	Q969W1	ZDH16_HUMAN	zinc finger, DHHC-type containing 16	359					apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	14		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		GGAATGGAATGAGCTGGGAGC	0.542000													3	14					0	0	1	0	0
ETV4	2118	broad.mit.edu	37	17	41622708	41622708	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:41622708C>T	ENST00000319349.5	-	3	386	c.88G>A	c.(88-90)Gaa>Aaa	p.E30K	ETV4_ENST00000545954.1_5'UTR|ETV4_ENST00000591713.1_Missense_Mutation_p.E30K|ETV4_ENST00000538265.1_5'UTR|ETV4_ENST00000393664.2_Missense_Mutation_p.E30K|ETV4_ENST00000545089.1_Missense_Mutation_p.E30K|RP11-392O1.4_ENST00000588996.1_RNA	NM_001079675.2	NP_001073143.1	P43268	ETV4_HUMAN	ets variant 4	30					positive regulation of transcription, DNA-dependent	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/ETV4(6)|CANT1/ETV4(3)|TMPRSS2/ETV4(13)|DDX5_ENST00000540698/ETV4(2)|KLK2/ETV4(2)	ovary(2)|upper_aerodigestive_tract(1)	3		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0798)		ATCAGCGCTTCGCGCAAGCTC	0.647000			T	"""EWSR1, TMPRSS2, DDX5, KLK2, CANT1"""	"""Ewing sarcoma, Prostate carcinoma"""								4	7					0	0	1	0	0
CD109	135228	broad.mit.edu	37	6	74512986	74512986	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:74512986C>G	ENST00000437994.2	+	24	3353	c.2922C>G	c.(2920-2922)ttC>ttG	p.F974L	CD109_ENST00000474094.1_3'UTR|CD109_ENST00000422508.2_Missense_Mutation_p.F897L|CD109_ENST00000287097.5_Missense_Mutation_p.F974L	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	974						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ATGGCTCTTTCAGTGCTTTTG	0.408000													10	55					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196871591	196871591	+	Silent	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:196871591A>G	ENST00000367416.2	+	2	236	c.99A>G	c.(97-99)ctA>ctG	p.L33L	CFHR2_ENST00000367421.3_Intron|CFHR4_ENST00000367418.2_Silent_p.L34L|CFHR4_ENST00000608469.1_Intron|CFHR4_ENST00000251424.4_Silent_p.L34L	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						ATGGAGGTCTATATTATAAGA	0.308000													24	112					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101194769	101194769	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:101194769C>T	ENST00000294728.2	+	5	1136	c.1035C>T	c.(1033-1035)ttC>ttT	p.F345F	VCAM1_ENST00000347652.2_Intron|VCAM1_ENST00000370119.4_Silent_p.F283F|VCAM1_ENST00000370115.1_Intron	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	345	Ig-like C2-type 4.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	CCCCATCTTTCTCCTGGAGAA	0.532000													9	87					0	0	1	0	0
SP1	6667	broad.mit.edu	37	12	53775907	53775907	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:53775907C>T	ENST00000426431.2	+	3	215	c.155C>T	c.(154-156)tCc>tTc	p.S52F	SP1_ENST00000327443.4_Missense_Mutation_p.S59F	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	59	Repressor domain.|Ser/Thr-rich.				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		TCCCAGCCATCCCCTTTGGCT	0.542000											OREG0021870	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	34					0	0	1	0	0
DAP3	7818	broad.mit.edu	37	1	155699109	155699109	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:155699109C>T	ENST00000368336.5	+	9	919	c.795C>T	c.(793-795)atC>atT	p.I265I	DAP3_ENST00000471642.2_Silent_p.I224I|DAP3_ENST00000421487.2_Silent_p.I231I|DAP3_ENST00000343043.3_Silent_p.I265I|DAP3_ENST00000535183.1_Silent_p.I224I|MSTO1_ENST00000538143.1_Intron|MSTO1_ENST00000452804.2_Intron	NM_001199849.1|NM_004632.3	NP_001186778.1|NP_004623.1	P51398	RT29_HUMAN	death associated protein 3	265					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	24	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TGGATGGAATCAATGCTCTTT	0.458000													14	143					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48285929	48285929	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:48285929G>T	ENST00000320048.1	+	1	517	c.517G>T	c.(517-519)Gac>Tac	p.D173Y		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D173Y(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						CAACATCATGGACCACTACTT	0.572000													7	52					5.18039e-06	5.32325e-06	1	1	0
GFPT1	2673	broad.mit.edu	37	2	69581639	69581639	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:69581639G>C	ENST00000357308.4	-	8	845	c.667C>G	c.(667-669)Cct>Gct	p.P223A	GFPT1_ENST00000361060.5_Missense_Mutation_p.P223A	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	223	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						TAGAGTATAGGAATGTGATCA	0.363000													9	136					0	0	1	0	0
TPI1	7167	broad.mit.edu	37	12	6979432	6979432	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:6979432C>T	ENST00000229270.4	+	7	1083	c.746C>T	c.(745-747)tCt>tTt	p.S249F	TPI1_ENST00000488464.2_Missense_Mutation_p.S130F|TPI1_ENST00000396705.5_Missense_Mutation_p.S212F|TPI1_ENST00000535434.1_Missense_Mutation_p.S130F	NM_001159287.1	NP_001152759.1	P60174	TPIS_HUMAN	triosephosphate isomerase 1	212					fatty acid biosynthetic process|gluconeogenesis|glycolysis|pentose-phosphate shunt	cytosol	triose-phosphate isomerase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(11)|prostate(1)|skin(2)	19						TTCCCAGGCTCTGTGACTGGG	0.597000											OREG0021638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	30					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55713439	55713439	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:55713439G>A	ENST00000376350.3	-	6	1160	c.1138C>T	c.(1138-1140)Cga>Tga	p.R380*	PTPRH_ENST00000588559.1_5'UTR|PTPRH_ENST00000263434.5_Nonsense_Mutation_p.R202*	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	380	Fibronectin type-III 4.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GTGGCATTTCGAGTCTCCCGG	0.473000													14	83					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131388549	131388549	+	Silent	SNP	T	T	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:131388549T>G	ENST00000512055.1	-	11	2777	c.651A>C	c.(649-651)ctA>ctC	p.L217L	CPNE4_ENST00000512332.1_Silent_p.L235L|CPNE4_ENST00000502818.1_Silent_p.L235L|CPNE4_ENST00000429747.1_Silent_p.L217L|CPNE4_ENST00000511604.1_Silent_p.L217L			Q96A23	CPNE4_HUMAN	copine IV	217	C2 2.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						CTCCGCTGCATAGAGAATTTA	0.393000													9	132					0	0	1	0	0
CTSD	1509	broad.mit.edu	37	11	1778686	1778686	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:1778686A>G	ENST00000236671.2	-	5	704	c.572T>C	c.(571-573)aTc>aCc	p.I191T	RP11-295K3.1_ENST00000427721.1_Missense_Mutation_p.S62P	NM_001909.4	NP_001900.1	P07339	CATD_HUMAN	cathepsin D	191					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(8)	13		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTGGCTGCGATGAAGGTGAT	0.622000											OREG0003774	type=REGULATORY REGION|Gene=CTSD|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	15					0	0	1	0	0
HMGCS2	3158	broad.mit.edu	37	1	120307011	120307011	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:120307011C>T	ENST00000369406.3	-	2	392	c.343G>A	c.(343-345)Gag>Aag	p.E115K	HMGCS2_ENST00000476640.1_5'UTR|HMGCS2_ENST00000544913.2_Missense_Mutation_p.E115K	NM_005518.3	NP_005509.1	P54868	HMCS2_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	115					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		TGTATGCGCTCCATCAGCCGT	0.547000													11	80					0	0	1	0	0
TACC1	6867	broad.mit.edu	37	8	38646286	38646286	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:38646286G>A	ENST00000379931.3	+	2	605	c.226G>A	c.(226-228)Gag>Aag	p.E76K	TACC1_ENST00000443286.2_Missense_Mutation_p.E92K|TACC1_ENST00000317827.4_Missense_Mutation_p.E76K|TACC1_ENST00000348567.4_Intron|TACC1_ENST00000519416.1_5'UTR|TACC1_ENST00000276520.8_Intron|TACC1_ENST00000520973.1_5'UTR|TACC1_ENST00000330691.6_Intron|TACC1_ENST00000518415.1_Missense_Mutation_p.E31K|TACC1_ENST00000520340.1_Missense_Mutation_p.E40K|TACC1_ENST00000520615.1_5'UTR|TACC1_ENST00000522752.1_Intron			O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing protein 1	76					cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(3)	17		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			ACCTTTCAAGGAGTCCTGTGA	0.448000													3	20					0	0	1	0	0
RPP14	11102	broad.mit.edu	37	3	58296276	58296276	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:58296276C>T	ENST00000445193.3	+	3	531	c.120C>T	c.(118-120)ttC>ttT	p.F40F	RPP14_ENST00000295959.5_Silent_p.F40F|RPP14_ENST00000477305.1_3'UTR|RPP14_ENST00000466547.1_Silent_p.F40F	NM_001098783.2	NP_001092253.1	O95059	RPP14_HUMAN	ribonuclease P/MRP 14kDa subunit						tRNA processing	nucleus	identical protein binding|ribonuclease P activity|RNA binding			large_intestine(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.000187)|KIRC - Kidney renal clear cell carcinoma(10;0.0102)|Kidney(10;0.0118)|OV - Ovarian serous cystadenocarcinoma(275;0.191)		CTGCACAGTTCAAACAGCTGC	0.343000													17	130					0	0	1	0	0
ZBTB48	3104	broad.mit.edu	37	1	6642229	6642229	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:6642229G>A	ENST00000377674.4	+	3	960	c.802G>A	c.(802-804)Gag>Aag	p.E268K		NM_001278647.1|NM_001278648.1|NM_005341.2	NP_001265576.1|NP_001265577.1|NP_005332.1	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	268						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		CTGTGCAGCTGAGCCAGCCCT	0.557000													16	35					0	0	1	0	0
PUM2	23369	broad.mit.edu	37	2	20508307	20508307	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:20508307A>C	ENST00000361078.2	-	5	579	c.557T>G	c.(556-558)gTa>gGa	p.V186G	PUM2_ENST00000536417.1_Missense_Mutation_p.V130G|PUM2_ENST00000403432.1_Missense_Mutation_p.V186G|PUM2_ENST00000420234.1_5'UTR|PUM2_ENST00000319801.5_Missense_Mutation_p.V186G|PUM2_ENST00000338086.5_Missense_Mutation_p.V186G			Q8TB72	PUM2_HUMAN	pumilio RNA-binding family member 2	186	Interaction with SNAPIN.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(7)|lung(13)|ovary(2)|prostate(4)|urinary_tract(3)	42	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCGCTCAACTACTTCAGTTGG	0.408000													31	76					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41518644	41518644	+	Silent	SNP	C	C	T	rs35661880	byFrequency	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:41518644C>T	ENST00000324071.4	+	8	1225	c.1218C>T	c.(1216-1218)gaC>gaT	p.D406D	CYP2B6_ENST00000330446.5_Silent_p.D206D|CYP2B6_ENST00000593831.1_Silent_p.D170D	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	406					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	AAAAACCAGACGCCTTCAATC	0.453000													48	125					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1210684	1210684	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:1210684G>A	ENST00000304460.10	+	3	525	c.469G>A	c.(469-471)Gag>Aag	p.E157K		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	157					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CCCGCTCAACGAGAACCAGAC	0.547000													3	24					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17555203	17555203	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:17555203G>A	ENST00000375471.4	+	7	828	c.736G>A	c.(736-738)Gag>Aag	p.E246K		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	246					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	AGGGGAGCAGGAGATCAAGTT	0.572000													70	106					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187516774	187516774	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:187516774A>C	ENST00000261023.3	+	15	1737	c.1463A>C	c.(1462-1464)aAt>aCt	p.N488T	AC017101.10_ENST00000453665.1_RNA|ITGAV_ENST00000433736.2_Missense_Mutation_p.N442T|ITGAV_ENST00000374907.3_Missense_Mutation_p.N452T	NM_002210.3	NP_002201	P06756	ITAV_HUMAN	integrin, alpha V	488					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		AATCAAGACAATAAAACCTGC	0.383000													17	61					0	0	1	0	0
SWSAP1	126074	broad.mit.edu	37	19	11486525	11486525	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:11486525C>T	ENST00000312423.2	+	2	582	c.523C>T	c.(523-525)Cca>Tca	p.P175S		NM_175871.3	NP_787067.2	Q6NVH7	CS039_HUMAN	SWIM-type zinc finger 7 associated protein 1	175																	TGCACCAGGTCCAGGAGAGCA	0.632000													7	16					0	0	1	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32498792	32498792	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:32498792G>A	ENST00000327300.7	+	4	795	c.628G>A	c.(628-630)Gaa>Aaa	p.E210K	KHDRBS1_ENST00000492989.1_Missense_Mutation_p.E171K|KHDRBS1_ENST00000307714.8_3'UTR	NM_006559.1	NP_006550.1	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal transduction associated 1	210					cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TCCATAGGAGGAAGAGCTGCG	0.458000													16	34					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160275264	160275264	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:160275264G>A	ENST00000241704.7	-	17	1855	c.1626C>T	c.(1624-1626)atC>atT	p.I542I	COPA_ENST00000368069.3_Silent_p.I551I	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	542					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TTGTGGTATAGATAAATACCC	0.433000													23	127					0	0	1	0	0
P4HB	5034	broad.mit.edu	37	17	79817265	79817265	+	Splice_Site	SNP	T	T	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:79817265T>A	ENST00000331483.4	-	2	368		c.e2-2		P4HB_ENST00000439918.2_Splice_Site|P4HB_ENST00000576390.1_Splice_Site	NM_000918.3	NP_000909.2	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta polypeptide						cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			NS(1)|breast(1)|large_intestine(2)|lung(17)|urinary_tract(1)	22	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			AAGGGGCATCTGGAAGCGGAA	0.542000													13	72					0	0	1	0	0
KCNK7	10089	broad.mit.edu	37	11	65361044	65361044	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:65361044G>A	ENST00000394216.2	-	2	844	c.621C>T	c.(619-621)ttC>ttT	p.F207F	KCNK7_ENST00000342202.4_Silent_p.F207F|KCNK7_ENST00000394217.2_Silent_p.F207F|KCNK7_ENST00000340313.4_Silent_p.F207F	NM_005714.1|NM_033455.1	NP_005705.1|NP_258416.1	Q9Y2U2	KCNK7_HUMAN	potassium channel, subfamily K, member 7	207						integral to membrane	potassium channel activity|voltage-gated ion channel activity			endometrium(1)|liver(1)|lung(1)	3						TGAGCGAGCTGAAGCAGAAGT	0.662000													5	17					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21747660	21747660	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:21747660C>T	ENST00000388958.3	+	21	2381	c.2380C>T	c.(2380-2382)Cag>Tag	p.Q794*	OTOA_ENST00000388957.3_Nonsense_Mutation_p.Q470*|OTOA_ENST00000388956.4_Nonsense_Mutation_p.Q715*|OTOA_ENST00000286149.4_Nonsense_Mutation_p.Q808*	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	808					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		GGCTGTCTTTCAGTCTGTTCG	0.468000													15	51					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56420411	56420411	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:56420411C>T	ENST00000370754.5	-	60	14774	c.14775G>A	c.(14773-14775)ctG>ctA	p.L4925L	DST_ENST00000312431.6_3'UTR|DST_ENST00000361203.3_Silent_p.L4745L|DST_ENST00000421834.2_Silent_p.L2659L|DST_ENST00000446842.2_Silent_p.L4421L|DST_ENST00000370769.4_Silent_p.L4747L|DST_ENST00000370788.2_Silent_p.L2659L|DST_ENST00000244364.6_Silent_p.L2333L			Q03001	DYST_HUMAN	dystonin	4745					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AAAGGCTTCTCAGCAGGCTTT	0.458000													4	50					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49700740	49700740	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:49700740C>A	ENST00000296452.4	+	7	11263	c.11149C>A	c.(11149-11151)Cat>Aat	p.H3717N		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	3717					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CGCATACCATCATGCCTCTGA	0.627000													9	62					1.76689e-08	1.83023e-08	1	1	0
GATA2	2624	broad.mit.edu	37	3	128202736	128202736	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:128202736C>A	ENST00000341105.2	-	4	1315	c.984G>T	c.(982-984)caG>caT	p.Q328H	GATA2_ENST00000487848.1_Missense_Mutation_p.Q328H|GATA2_ENST00000430265.2_Missense_Mutation_p.Q328H	NM_032638.4	NP_116027.2	P23769	GATA2_HUMAN	GATA binding protein 2	328					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(58)|kidney(2)|large_intestine(3)|lung(9)|prostate(3)|skin(1)|urinary_tract(1)	79				GBM - Glioblastoma multiforme(114;0.173)		GTGGTCGGTTCTGCCCATTCA	0.632000			Mis		AML(CML blast transformation)								4	55					0.00024832	0.000253147	1	1	0
CSHL1	1444	broad.mit.edu	37	17	61987969	61987969	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:61987969C>G	ENST00000392824.4	-	2	387	c.326G>C	c.(325-327)aGa>aCa	p.R109T	CSHL1_ENST00000561003.1_Intron|CSHL1_ENST00000346606.6_Intron|CSHL1_ENST00000309894.5_Intron|CSHL1_ENST00000259003.10_Intron|CSHL1_ENST00000450719.3_Intron|CSHL1_ENST00000438387.2_Intron|CSHL1_ENST00000558099.1_5'UTR			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	0						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						CACTGTTACTCTTCTGGGAAC	0.522000													10	80					0	0	1	0	0
SLC18A1	6570	broad.mit.edu	37	8	20036725	20036725	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:20036725A>G	ENST00000440926.1	-	4	865	c.395T>C	c.(394-396)tTg>tCg	p.L132S	SLC18A1_ENST00000381608.4_Missense_Mutation_p.L132S|SLC18A1_ENST00000437980.1_Missense_Mutation_p.L132S|SLC18A1_ENST00000276373.5_Missense_Mutation_p.L132S|SLC18A1_ENST00000265808.7_Missense_Mutation_p.L132S|SLC18A1_ENST00000519026.1_Missense_Mutation_p.L132S	NM_001135691.2	NP_001129163.1	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 1	132					neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29				Colorectal(74;0.0747)		CTCTTCCTCCAAGAAACCTGT	0.517000													20	48					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6852987	6852987	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:6852987G>T	ENST00000304076.2	+	24	2257	c.2163G>T	c.(2161-2163)gaG>gaT	p.E721D	VAV1_ENST00000596764.1_Missense_Mutation_p.E711D|VAV1_ENST00000602142.1_Missense_Mutation_p.E743D|VAV1_ENST00000539284.1_Missense_Mutation_p.E646D|VAV1_ENST00000599806.1_Missense_Mutation_p.E688D	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	743	SH2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						AGCTGGTGGAGTTTTACCAGC	0.542000													3	29					0.115264	0.115591	1	1	0
POTEC	388468	broad.mit.edu	37	18	14533148	14533148	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr18:14533148G>A	ENST00000358970.5	-	5	966	c.967C>T	c.(967-969)Ctt>Ttt	p.L323F	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	323										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TCAAGGAGAAGATTGACTATA	0.363000													19	178					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31299615	31299615	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:31299615G>A	ENST00000265071.2	+	5	953	c.688G>A	c.(688-690)Gag>Aag	p.E230K	CDH6_ENST00000514738.1_Missense_Mutation_p.E175K	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	230	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AGAAAACAGGGAGCAGTACCA	0.448000													13	63					0	0	1	0	0
UBQLN2	29978	broad.mit.edu	37	X	56590814	56590814	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:56590814C>G	ENST00000338222.5	+	1	789	c.508C>G	c.(508-510)Cag>Gag	p.Q170E		NM_013444.3	NP_038472.2	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	170						cytoplasm|nucleus|plasma membrane	binding			breast(2)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)	21						GCTCCAGAGCCAGATGCAGCA	0.527000													5	16					0	0	1	0	0
ELAVL1	1994	broad.mit.edu	37	19	8028433	8028433	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:8028433C>T	ENST00000407627.2	-	6	1044	c.915G>A	c.(913-915)ctG>ctA	p.L305L	ELAVL1_ENST00000351593.5_Silent_p.L332L|ELAVL1_ENST00000596459.1_Silent_p.L305L	NM_001419.2	NP_001410.2	Q15717	ELAV1_HUMAN	ELAV like RNA binding protein 1	305	RRM 3.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						GGTAGCCGTTCAGGCTGGCTA	0.458000													14	93					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	62939627	62939627	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:62939627G>A	ENST00000561311.1	+	3	348	c.118G>A	c.(118-120)Gag>Aag	p.E40K	TLN2_ENST00000306829.6_Missense_Mutation_p.E40K			Q9Y4G6	TLN2_HUMAN	talin 2	40					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						ACGGGTGCCTGAGGCACAAAC	0.473000													19	86					0	0	1	0	0
TMED6	146456	broad.mit.edu	37	16	69377369	69377369	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr16:69377369A>C	ENST00000288025.3	-	4	719	c.664T>G	c.(664-666)Ttc>Gtc	p.F222V	RP11-343C2.9_ENST00000563634.1_Intron|RP11-343C2.7_ENST00000564737.1_Intron	NM_144676.3	NP_653277.2	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain containing 6	222					transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|kidney(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	9						CGCTTCAAGAAATACAGTTGC	0.438000													7	85					0	0	1	0	0
TMUB2	79089	broad.mit.edu	37	17	42268209	42268209	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:42268209G>T	ENST00000319511.6	+	3	1533	c.883G>T	c.(883-885)Gta>Tta	p.V295L	TMUB2_ENST00000538716.2_Missense_Mutation_p.V315L|TMUB2_ENST00000589184.1_3'UTR|TMUB2_ENST00000592825.1_3'UTR|TMUB2_ENST00000590235.1_3'UTR|TMUB2_ENST00000357984.3_Missense_Mutation_p.V295L|TMUB2_ENST00000446571.3_Missense_Mutation_p.V258L|TMUB2_ENST00000587172.1_3'UTR|TMUB2_ENST00000589785.1_Missense_Mutation_p.V295L|TMUB2_ENST00000587989.1_Missense_Mutation_p.V315L	NM_177441.2	NP_803190.2	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain containing 2	315						integral to membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)	8		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CAGCTTCCTAGTATTTGGGAT	0.512000													14	119					1.15088e-07	1.18865e-07	1	1	0
TMC1	117531	broad.mit.edu	37	9	75315549	75315549	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr9:75315549G>C	ENST00000297784.5	+	8	892	c.352G>C	c.(352-354)Gaa>Caa	p.E118Q	TMC1_ENST00000340019.3_Missense_Mutation_p.E118Q|TMC1_ENST00000396237.3_Missense_Mutation_p.E118Q	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	118	Arg/Asp/Glu/Lys-rich (highly charged).				sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						GAAGAAAATTGAAGTTCTCAA	0.308000													6	37					0	0	1	0	0
STEAP3	55240	broad.mit.edu	37	2	120003079	120003079	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:120003079G>A	ENST00000354888.5	+	3	511	c.7G>A	c.(7-9)Gaa>Aaa	p.E3K	STEAP3_ENST00000393110.2_Missense_Mutation_p.E13K|STEAP3_ENST00000425223.2_Missense_Mutation_p.E3K|STEAP3_ENST00000393107.2_Missense_Mutation_p.E3K|STEAP3_ENST00000393106.2_Missense_Mutation_p.E3K|STEAP3_ENST00000393108.2_Missense_Mutation_p.E3K|STEAP3-AS1_ENST00000454260.1_RNA|STEAP3_ENST00000409811.1_Missense_Mutation_p.E3K|STEAP3_ENST00000450943.2_Missense_Mutation_p.E3K	NM_182915.2	NP_878919.2	Q658P3	STEA3_HUMAN	STEAP family member 3, metalloreductase	3					apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	17						CAAAATGCCAGAAGAGATGGA	0.572000													6	45					0	0	1	0	0
CD109	135228	broad.mit.edu	37	6	74516760	74516760	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:74516760A>C	ENST00000437994.2	+	25	3585	c.3154A>C	c.(3154-3156)Att>Ctt	p.I1052L	CD109_ENST00000422508.2_Missense_Mutation_p.I975L|CD109_ENST00000287097.5_Missense_Mutation_p.I1052L	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	1052						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TACAGCCTATATTGTAACTTC	0.373000													15	43					0	0	1	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33016947	33016947	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:33016947G>A	ENST00000357505.6	-	7	1786	c.1682C>T	c.(1681-1683)tCt>tTt	p.S561F	N4BP2L2_ENST00000399396.3_Missense_Mutation_p.S576F|N4BP2L2_ENST00000446957.2_Intron|N4BP2L2_ENST00000504114.1_Missense_Mutation_p.S561F|N4BP2L2_ENST00000380121.3_5'UTR	NM_001278432.1	NP_001265361.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	0	Poly-Pro.									kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		CAGGCAATGAGAATAACGCTG	0.323000													4	27					0	0	1	0	0
TMPRSS4	56649	broad.mit.edu	37	11	117975521	117975521	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:117975521G>A	ENST00000522307.1	+	0	583				TMPRSS4_ENST00000523251.1_Silent_p.Q102Q|TMPRSS4_ENST00000534111.1_Silent_p.Q140Q|TMPRSS4_ENST00000522824.1_Silent_p.Q142Q|TMPRSS4_ENST00000437212.3_Silent_p.Q142Q			Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4						proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		CCTGTAGGCAGATGGGCTACA	0.552000													3	35					0	0	1	0	0
PHLDB3	653583	broad.mit.edu	37	19	44008075	44008075	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:44008075C>T	ENST00000292140.5	-	2	556	c.196G>A	c.(196-198)Gag>Aag	p.E66K	PHLDB3_ENST00000599242.1_Missense_Mutation_p.E66K	NM_198850.3	NP_942147.3	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B, member 3	66										breast(1)|central_nervous_system(1)|lung(5)	7		Prostate(69;0.0153)				CGGCTGCTCTCAGTGCTGCTG	0.677000													8	33					0	0	1	0	0
LDHAL6B	92483	broad.mit.edu	37	15	59499894	59499894	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:59499894G>C	ENST00000307144.4	+	1	853	c.755G>C	c.(754-756)gGa>gCa	p.G252A	MYO1E_ENST00000288235.4_Intron	NM_033195.2	NP_149972.1	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	252					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)	10					NADH(DB00157)	GTGTGGAGTGGAGTGAACATA	0.443000													16	59					0	0	1	0	0
MIF4GD	57409	broad.mit.edu	37	17	73266270	73266270	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:73266270C>A	ENST00000577542.1	-	2	269	c.7G>T	c.(7-9)Gag>Tag	p.E3*	MIF4GD_ENST00000325102.8_Nonsense_Mutation_p.E3*|MIF4GD_ENST00000245551.5_Nonsense_Mutation_p.E3*|MIF4GD_ENST00000579119.1_Nonsense_Mutation_p.E3*|MIF4GD_ENST00000579297.1_Nonsense_Mutation_p.E3*|MIF4GD_ENST00000578305.1_Nonsense_Mutation_p.E3*|MIF4GD_ENST00000580571.1_Nonsense_Mutation_p.E3*			A9UHW6	MI4GD_HUMAN	MIF4G domain containing	3	MIF4G.				regulation of translation|RNA metabolic process	cytoplasm|nucleus	protein C-terminus binding			breast(2)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)	10	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			CTACTGGGCTCCCCCATGACT	0.587000													35	161					2.47316e-13	2.5864e-13	1	1	0
WDR82	80335	broad.mit.edu	37	3	52294512	52294512	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:52294512G>A	ENST00000296490.3	-	5	713	c.432C>T	c.(430-432)ctC>ctT	p.L144L		NM_025222.3	NP_079498.2	Q6UXN9	WDR82_HUMAN	WD repeat domain 82	144					histone H3-K4 methylation	chromatin|PTW/PP1 phosphatase complex|Set1C/COMPASS complex	protein binding								BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		GCAGATGCATGAGGCCCTAAG	0.408000													11	67					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124387150	124387150	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:124387150G>A	ENST00000303921.2	-	2	1921	c.1271C>T	c.(1270-1272)tCt>tTt	p.S424F		NM_005302.3	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	424						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TAAATCAGGAGAGATCTTAAT	0.483000													6	69					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54133761	54133761	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:54133761G>A	ENST00000404125.1	-	26	2972	c.2917C>T	c.(2917-2919)Cgt>Tgt	p.R973C	PSME4_ENST00000421748.2_Missense_Mutation_p.R117C	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	973					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GTAGATAAACGAAGAAGATCT	0.363000													7	62					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10315693	10315693	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:10315693G>A	ENST00000403437.2	-	14	1504	c.1410C>T	c.(1408-1410)atC>atT	p.I470I	CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000399342.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	470	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TCACATCAAAGATTTCAAAGC	0.423000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				24	129					0	0	1	0	0
FBXO32	114907	broad.mit.edu	37	8	124525576	124525576	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:124525576C>T	ENST00000517956.1	-	6	704	c.513G>A	c.(511-513)caG>caA	p.Q171Q	FBXO32_ENST00000443022.2_Intron	NM_058229.3|NM_148177.2	NP_478136.1|NP_680482.1	Q969P5	FBX32_HUMAN	F-box protein 32	171										autonomic_ganglia(1)|breast(3)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)|stomach(1)	21	Lung NSC(37;1.13e-13)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TGTAGAGGGTCTGGAGTAGTT	0.428000													6	34					0	0	1	0	0
NOXRED1	122945	broad.mit.edu	37	14	77872354	77872354	+	Silent	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:77872354C>T	ENST00000380835.2	-	5	973	c.807G>A	c.(805-807)gtG>gtA	p.V269V		NM_001113475.2	NP_001106946.1	Q6NXP6	CN148_HUMAN	NADP-dependent oxidoreductase domain containing 1	269					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	9						CTTCAAAGTGCACGGAGAGAA	0.473000													5	19					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56417578	56417578	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:56417578C>T	ENST00000370754.5	-	61	15918	c.15919G>A	c.(15919-15921)Gac>Aac	p.D5307N	DST_ENST00000312431.6_3'UTR|DST_ENST00000361203.3_Missense_Mutation_p.D5127N|DST_ENST00000421834.2_Missense_Mutation_p.D3041N|DST_ENST00000446842.2_Missense_Mutation_p.D4803N|DST_ENST00000370769.4_Missense_Mutation_p.D5129N|DST_ENST00000370788.2_Missense_Mutation_p.D3041N|DST_ENST00000244364.6_Missense_Mutation_p.D2715N			Q03001	DYST_HUMAN	dystonin	5127					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ACCACAAGGTCCTGTGCAAGT	0.443000													5	67					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77743843	77743843	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr13:77743843T>C	ENST00000407578.2	-	39	6067	c.5801A>G	c.(5800-5802)gAc>gGc	p.D1934G	MYCBP2_ENST00000544440.2_Missense_Mutation_p.D1896G|MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000357337.6_Missense_Mutation_p.D1896G	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1896					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTCTGGAATGTCATCAGCTAA	0.393000													8	48					0	0	1	0	0
ZNF800	168850	broad.mit.edu	37	7	127014816	127014816	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr7:127014816C>T	ENST00000393313.1	-	5	1165	c.574G>A	c.(574-576)Gag>Aag	p.E192K	ZNF800_ENST00000393312.1_Missense_Mutation_p.E192K|ZNF800_ENST00000265827.3_Missense_Mutation_p.E192K			Q2TB10	ZN800_HUMAN	zinc finger protein 800	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						GGAGGGGGCTCTACAGTTTCC	0.453000													17	98					0	0	1	0	0
PAX3	5077	broad.mit.edu	37	2	223161715	223161715	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:223161715G>A	ENST00000350526.4	-	2	439	c.303C>T	c.(301-303)atC>atT	p.I101I	PAX3_ENST00000409551.3_Silent_p.I101I|PAX3_ENST00000409828.3_Silent_p.I101I|PAX3_ENST00000344493.4_Silent_p.I101I|PAX3_ENST00000392070.2_Silent_p.I101I|PAX3_ENST00000258387.5_Silent_p.I101I|PAX3_ENST00000392069.2_Silent_p.I101I|PAX3_ENST00000336840.6_Silent_p.I101I	NM_181457.3	NP_852122.1	P23760	PAX3_HUMAN	paired box 3	101	Paired.				apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGCTGCCGCCGATGGCACCAG	0.682000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						8	13					0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18234051	18234051	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr19:18234051C>T	ENST00000262811.6	+	6	337	c.337C>T	c.(337-339)Ctc>Ttc	p.L113F	MAST3_ENST00000608648.1_3'UTR	NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3								ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						CCGGGAACGTCTCCACCAGCT	0.612000													4	35					0	0	1	0	0
KIAA0754	643314	broad.mit.edu	37	1	39876954	39876954	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:39876954G>C	ENST00000530275.1	+	1	804	c.609G>C	c.(607-609)gaG>gaC	p.E203D	MACF1_ENST00000289893.4_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000372915.3_Intron|MACF1_ENST00000567887.1_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000564288.1_Intron|MACF1_ENST00000317713.7_Intron	NM_015038.1	NP_055853.1	O94854	K0754_HUMAN	KIAA0754	203										central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGGAGGAAGAGAAACTGTCAG	0.468000											OREG0013393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	115	59					0	0	1	0	0
N6AMT1	29104	broad.mit.edu	37	21	30257653	30257653	+	Silent	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:30257653G>A	ENST00000303775.5	-	1	40	c.15C>T	c.(13-15)aaC>aaT	p.N5N	N6AMT1_ENST00000351429.3_Silent_p.N5N	NM_013240.4	NP_037372	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1 (putative)	5					positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)	12						GCGTAGCGAAGTTCTCCCCTG	0.667000													8	23					0	0	1	0	0
CHRDL2	25884	broad.mit.edu	37	11	74422010	74422010	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:74422010C>T	ENST00000376332.3	-	4	812	c.316G>A	c.(316-318)Gcc>Acc	p.A106T	CHRDL2_ENST00000534159.1_5'UTR|CHRDL2_ENST00000263671.5_Missense_Mutation_p.A106T	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	106					cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					TTTGGTGGGGCCCGGAGTCCA	0.557000													5	21					0	0	1	0	0
DDX5	1655	broad.mit.edu	37	17	62499668	62499668	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:62499668G>A	ENST00000225792.5	-	6	930	c.529C>T	c.(529-531)Cgg>Tgg	p.R177W	DDX5_ENST00000578804.1_Missense_Mutation_p.R177W|DDX5_ENST00000450599.2_Missense_Mutation_p.R98W	NM_004396.3	NP_004387.1	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 5	177	Helicase ATP-binding.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	19	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			GCCAGTTCCCGAGTTGGTGCC	0.453000			T	ETV4	prostate								7	82					0	0	1	0	0
TXLNG	55787	broad.mit.edu	37	X	16857974	16857974	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:16857974G>A	ENST00000380122.5	+	9	1244	c.1183G>A	c.(1183-1185)Gaa>Aaa	p.E395K	TXLNG_ENST00000398155.4_Missense_Mutation_p.E263K|TXLNG_ENST00000485153.1_3'UTR	NM_018360.2	NP_060830.2	Q9NUQ3	TXLNG_HUMAN	taxilin gamma	395					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane				breast(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	15						ACTGGAAAAAGAAACAATAAT	0.363000													5	38					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64604625	64604625	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:64604625G>A	ENST00000357395.3	+	80	15066	c.3922G>A	c.(3922-3924)Gag>Aag	p.E1308K	SYNE2_ENST00000394768.2_Missense_Mutation_p.E1308K|SYNE2_ENST00000344113.4_Missense_Mutation_p.E4923K|SYNE2_ENST00000554584.1_Missense_Mutation_p.E4840K|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000555002.1_Missense_Mutation_p.E1557K|SYNE2_ENST00000358025.3_Missense_Mutation_p.E4923K			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4923					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAAACTGGAAGAGCAGTGGTT	0.512000													8	42					0	0	1	0	0
GSTM2	2946	broad.mit.edu	37	1	110214111	110214117	+	Frame_Shift_Del	DEL	TCATCGC	TCATCGC	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:110214111_110214117delTCATCGC	ENST00000369831.2	+	7	567_573	c.473_479delTCATCGC	c.(472-480)ttcatcgctfs	p.FIA158fs	GSTM2_ENST00000241337.4_Frame_Shift_Del_p.FIA158fs|GSTM2_ENST00000369829.2_Frame_Shift_Del_p.FIA158fs|GSTM2_ENST00000460717.3_Frame_Shift_Del_p.FIA158fs|GSTM2_ENST00000369827.3_Intron|GSTM2_ENST00000414179.2_Frame_Shift_Del_p.FIA54fs|GSTM2_ENST00000442650.1_Frame_Shift_Del_p.FIA158fs					glutathione S-transferase mu 2 (muscle)											kidney(1)|large_intestine(2)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	11		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)		TTTGTGGATTTCATCGCTTATGATGTC	0.488													8	88	---	---	---	---					
TRIM67	440730	broad.mit.edu	37	1	231344829	231344830	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr1:231344829_231344830insT	ENST00000444294.3	+	8	2808_2809	c.1950_1951insT	c.(1951-1953)tggfs	p.W651fs	TRIM67_ENST00000366652.2_Frame_Shift_Ins_p.W653fs|TRIM67_ENST00000449018.3_Frame_Shift_Ins_p.W591fs|TRIM67_ENST00000366653.5_Frame_Shift_Ins_p.W653fs	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	653	B30.2/SPRY.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GCGTGCACTACTGGGAGCTGCA	0.609													13	107	---	---	---	---					
C2orf71	388939	broad.mit.edu	37	2	29295647	29295649	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:29295647_29295649delTCC	ENST00000331664.5	-	1	1478_1480	c.1479_1481delGGA	c.(1477-1482)gaggaa>gaa	p.493_494EE>E		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	493					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CATTTTGTCTTCCTCCTCCTCCT	0.542													9	179	---	---	---	---					
LINC01158	100506421	broad.mit.edu	37	2	105440927	105440929	+	RNA	DEL	TGG	TGG	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr2:105440927_105440929delTGG	ENST00000458253.1	-	0	147				AC018730.1_ENST00000454729.1_RNA|AC018730.1_ENST00000447876.1_RNA|AC018730.1_ENST00000443988.1_RNA|AC018730.1_ENST00000413121.1_RNA																							gtggtggtgatggtggtggtggt	0.591													4	6	---	---	---	---					
TRMT10C	54931	broad.mit.edu	37	3	101284009	101284009	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr3:101284009delA	ENST00000309922.6	+	2	538	c.384delA	c.(382-384)gcafs	p.A128fs		NM_017819.2	NP_060289.2			tRNA methyltransferase 10 homolog C (S. cerevisiae)																		CTAACACAGCaaaaaaaaaat	0.343													8	44	---	---	---	---					
HNRNPD	3184	broad.mit.edu	37	4	83277772	83277773	+	Frame_Shift_Ins	INS	-	-	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr4:83277772_83277773insC	ENST00000313899.7	-	7	1194_1195	c.917_918insG	c.(916-918)ggafs	p.G306fs	HNRNPD_ENST00000508119.1_Intron|HNRNPD_ENST00000352301.4_Frame_Shift_Ins_p.G287fs|HNRNPD_ENST00000353341.4_Intron|HNRNPD_ENST00000543098.1_Frame_Shift_Ins_p.G254fs|HNRNPD_ENST00000541060.1_Frame_Shift_Ins_p.G152fs	NM_031370.2	NP_112738.1	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	306	Gly-rich.|Tyr-rich.				nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	7						GGCTGTTATATCCATAGTTGCC	0.391													7	62	---	---	---	---					
ZNF622	90441	broad.mit.edu	37	5	16465274	16465289	+	Frame_Shift_Del	DEL	CCCACGGCCACCAGTA	CCCACGGCCACCAGTA	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr5:16465274_16465289delCCCACGGCCACCAGTA	ENST00000308683.2	-	1	612_627	c.486_501delTACTGGTGGCCGTGGG	c.(484-501)ggtactggtggccgtgggfs	p.GTGGRG162fs		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	162						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						GGTCGTGGGTCCCACGGCCACCAGTACCCACGGCCA	0.648													17	74	---	---	---	---					
HLA-DRB6	3128	broad.mit.edu	37	6	32521769	32521771	+	RNA	DEL	ATT	ATT	-	rs77824792	by1000genomes	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:32521769_32521771delATT	ENST00000411500.1	-	0	740					NR_001298.1																						AGGTTTAGTGATTTTTATTCCAA	0.429													3	5	---	---	---	---					
ASCC3	10973	broad.mit.edu	37	6	101073163	101073176	+	Frame_Shift_Del	DEL	ATGAGACAAATATC	ATGAGACAAATATC	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr6:101073163_101073176delATGAGACAAATATC	ENST00000369162.2	-	30	5021_5034	c.4677_4690delGATATTTGTCTCAT	c.(4675-4692)ttgatatttgtctcatcafs	p.LIFVSS1559fs		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	1559	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TGACGTCTTGATGAGACAAATATCAAAACAGGTT	0.388													7	42	---	---	---	---					
SGK223	157285	broad.mit.edu	37	8	8234868	8234869	+	In_Frame_Ins	INS	-	-	GCCGCT	rs59372311	by1000genomes	TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:8234868_8234869insGCCGCT	ENST00000520004.1	-	3	1314_1315	c.1050_1051insAGCGGC	c.(1048-1053)ggcgcc>ggcAGCGGCgcc	p.349_350insGS	SGK223_ENST00000330777.4_In_Frame_Ins_p.349_350insGS			Q86YV5	SG223_HUMAN		349							ATP binding|non-membrane spanning protein tyrosine kinase activity	p.G350_A351insSG(1)|p.G350_S351insSG(1)									GGGCTACTGGCGCCGCTGCCGC	0.653													3	3	---	---	---	---					
PDGFRL	5157	broad.mit.edu	37	8	17478585	17478603	+	Frame_Shift_Del	DEL	CAGTTGACTCTGGTCAACT	CAGTTGACTCTGGTCAACT	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr8:17478585_17478603delCAGTTGACTCTGGTCAACT	ENST00000541323.1	+	4	824_842	c.379_397delCAGTTGACTCTGGTCAACT	c.(379-399)cagttgactctggtcaactccfs	p.QLTLVNS127fs	PDGFRL_ENST00000398074.3_Frame_Shift_Del_p.QLTLVNS127fs|PDGFRL_ENST00000251630.6_Frame_Shift_Del_p.QLTLVNS127fs	NM_006207.2	NP_006198.1	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	127	Ig-like C2-type 1.					extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity	p.N132S(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	9				Colorectal(111;0.0752)		GCGCTACGGCCAGTTGACTCTGGTCAACTCCACCTCGGC	0.562													7	50	---	---	---	---					
GPRIN2	9721	broad.mit.edu	37	10	46999684	46999684	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr10:46999684delT	ENST00000374314.4	+	1	1759	c.804delT	c.(802-804)tctfs	p.S268fs	GPRIN2_ENST00000374317.1_Frame_Shift_Del_p.S268fs			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	268										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						TGAGCGAGTCTGGGCTGCAGG	0.627													14	110	---	---	---	---					
PRPF19	27339	broad.mit.edu	37	11	60665373	60665374	+	Frame_Shift_Ins	INS	-	-	C			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr11:60665373_60665374insC	ENST00000227524.4	-	15	1566_1567	c.1361_1362insG	c.(1360-1362)ggcfs	p.G454fs		NM_014502.4	NP_055317.1	Q9UMS4	PRP19_HUMAN	pre-mRNA processing factor 19	454					DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	22						GGACATCCGTGCCCCCAAGAGC	0.510													8	126	---	---	---	---					
LGR5	8549	broad.mit.edu	37	12	71960477	71960492	+	Splice_Site	DEL	GTCTGTAAGTACTGAG	GTCTGTAAGTACTGAG	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr12:71960477_71960492delGTCTGTAAGTACTGAG	ENST00000266674.5	+	10	1306_1309	c.995_998delGTCTGTAAGTACTGAG	c.(994-999)agtctg>ag	p.SL332fs	LGR5_ENST00000536515.1_Splice_Site_p.SL260fs|LGR5_ENST00000540815.2_Splice_Site_p.SL308fs			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	332						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						AACCTGGAGAGTCTGTAAGTACTGAGTAGACTCTTG	0.394													10	209	---	---	---	---					
KIAA0391	9692	broad.mit.edu	37	14	35593316	35593316	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:35593316delG	ENST00000557565.1	+	2	1246	c.865delG	c.(865-867)ggafs	p.G289fs	KIAA0391_ENST00000605870.1_Intron|KIAA0391_ENST00000603544.1_Frame_Shift_Del_p.G289fs|KIAA0391_ENST00000321130.10_Frame_Shift_Del_p.G289fs|KIAA0391_ENST00000250377.7_Frame_Shift_Del_p.G194fs|KIAA0391_ENST00000604948.1_Frame_Shift_Del_p.G194fs|KIAA0391_ENST00000603588.1_Intron|KIAA0391_ENST00000534898.4_Frame_Shift_Del_p.G289fs	NM_001282234.1	NP_001269163.1	O15091	MRRP3_HUMAN	KIAA0391	289					tRNA processing	mitochondrion				central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	14	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		CTTTGATTTTGGAAAAGACAT	0.323													12	38	---	---	---	---					
IRF2BPL	64207	broad.mit.edu	37	14	77493648	77493650	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr14:77493648_77493650delGCG	ENST00000238647.3	-	1	1384_1386	c.486_488delCGC	c.(484-489)gccgct>gct	p.162_163AA>A		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	162	Poly-Ala.					nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						TTCCACCgcagcggcggcggcgg	0.749													2	4	---	---	---	---					
ZWILCH	55055	broad.mit.edu	37	15	66821260	66821261	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr15:66821260_66821261insT	ENST00000307897.5	+	11	1420_1421	c.1040_1041insT	c.(1039-1044)gattttfs	p.DF347fs	ZWILCH_ENST00000446801.2_Frame_Shift_Ins_p.DF233fs|ZWILCH_ENST00000535141.2_Frame_Shift_Ins_p.DF233fs|ZWILCH_ENST00000565627.1_Frame_Shift_Ins_p.DF233fs	NM_017975.3	NP_060445.3	Q9H900	ZWILC_HUMAN	zwilch kinetochore protein	347					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(1)|lung(6)|ovary(1)	18						AGTGATCTTGATTTTGCTGAGC	0.386													8	40	---	---	---	---					
HAP1	9001	broad.mit.edu	37	17	39884456	39884456	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr17:39884456delC	ENST00000393939.2	-	7	1206	c.1197delG	c.(1195-1197)cggfs	p.R399fs	HAP1_ENST00000341193.5_Frame_Shift_Del_p.R407fs|HAP1_ENST00000310778.5_Frame_Shift_Del_p.R399fs|JUP_ENST00000540235.1_Intron|HAP1_ENST00000347901.4_Frame_Shift_Del_p.R399fs			P54257	HAP1_HUMAN	huntingtin-associated protein 1	399	Glu-rich.|HAP1 N-terminal.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			GACTCACCATCCGGCAGCGCT	0.642													10	51	---	---	---	---					
PHF20	51230	broad.mit.edu	37	20	34459591	34459591	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr20:34459591delG	ENST00000374012.3	+	9	1251	c.1122delG	c.(1120-1122)ttgfs	p.L374fs	PHF20_ENST00000481202.1_3'UTR|PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	374					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding	p.L374F(1)		breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					AGTCTGCTTTGGAAGCTGGCC	0.448													9	148	---	---	---	---					
TIAM1	7074	broad.mit.edu	37	21	32493114	32493116	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chr21:32493114_32493116delGCC	ENST00000286827.3	-	29	4817_4819	c.4346_4348delGGC	c.(4345-4350)cggctg>ctg	p.R1449del	TIAM1_ENST00000541036.1_In_Frame_Del_p.R1389del	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1449	Poly-Arg.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TTTCGAGCCAGCCGCCGCCTCCT	0.537													12	28	---	---	---	---					
ZNF185	7739	broad.mit.edu	37	X	152087570	152087572	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-ZF-A9RC-01A-11D-A38G-08	TCGA-ZF-A9RC-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02b74d13-0b03-4bfa-892f-4833f468c29c	51ef3988-3292-4d08-b1c3-4a3499d5645a	g.chrX:152087570_152087572delGAG	ENST00000535861.1	+	7	523_525	c.475_477delGAG	c.(475-477)gagdel	p.E165del	ZNF185_ENST00000449285.2_In_Frame_Del_p.E165del|ZNF185_ENST00000539731.1_In_Frame_Del_p.E165del|ZNF185_ENST00000324823.6_In_Frame_Del_p.E30del|ZNF185_ENST00000370270.2_In_Frame_Del_p.E165del|ZNF185_ENST00000318529.8_In_Frame_Del_p.E30del|ZNF185_ENST00000318504.7_In_Frame_Del_p.E165del|ZNF185_ENST00000370268.4_In_Frame_Del_p.E165del	NM_001178106.1	NP_001171577.1	O15231	ZN185_HUMAN	zinc finger protein 185 (LIM domain)	165	Poly-Glu.					cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(3)	12	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGGACACCgaggaggaggagg	0.596													2	4	---	---	---	---					
