Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FCRL4	83417	broad.mit.edu	37	1	157545345	157545345	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:157545345C>T	ENST00000271532.1	-	12	1652	c.1517G>A	c.(1516-1518)gGa>gAa	p.G506E	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	506						integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GCTGATCTTTCCAGCTGAGTT	0.453000													16	51					0	0	1	0	0
BBC3	27113	broad.mit.edu	37	19	47725002	47725002	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:47725002G>C	ENST00000449228.1	-	4	905	c.742C>G	c.(742-744)Cct>Gct	p.P248A	BBC3_ENST00000341983.4_3'UTR|BBC3_ENST00000439096.2_3'UTR|BBC3_ENST00000300880.7_Missense_Mutation_p.P88A	NM_001127240.2	NP_001120712.1	Q9BXH1	BBC3_HUMAN	BCL2 binding component 3	0					activation of caspase activity|activation of pro-apoptotic gene products|cellular response to hypoxia|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of growth|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|positive regulation of thymocyte apoptosis|protein insertion into mitochondrial membrane involved in induction of apoptosis|reduction of endoplasmic reticulum calcium ion concentration|release of cytochrome c from mitochondria|release of sequestered calcium ion into cytosol	cytosol|mitochondrial outer membrane	protein binding			endometrium(1)|lung(2)|skin(1)	4		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.000179)|OV - Ovarian serous cystadenocarcinoma(262;0.00029)|Epithelial(262;0.0103)|GBM - Glioblastoma multiforme(486;0.0234)		AGGGTGTCAGGAGGTGGGAGG	0.706000													3	5					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62397071	62397071	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr11:62397071G>A	ENST00000346178.4	-	16	1904	c.1889C>T	c.(1888-1890)tCc>tTc	p.S630F	GANAB_ENST00000356638.3_Missense_Mutation_p.S608F|GANAB_ENST00000540933.1_Missense_Mutation_p.S511F|GANAB_ENST00000534779.1_Missense_Mutation_p.S516F	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	608					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						AAAGCGCTGGGAGCCAGCGAA	0.602000													7	36					0	0	1	0	0
PSKH1	5681	broad.mit.edu	37	16	67943151	67943151	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:67943151C>T	ENST00000291041.5	+	2	669	c.499C>T	c.(499-501)Cgg>Tgg	p.R167W		NM_006742.2	NP_006733.1	P11801	KPSH1_HUMAN	protein serine kinase H1	167	Protein kinase.					endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|nuclear speck|plasma membrane	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(7)|pancreas(1)	12		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0044)|Epithelial(162;0.0197)|all cancers(182;0.128)		GACACAGGAGCGGGTGTACAT	0.637000													4	33					0	0	1	0	0
ANGPT2	285	broad.mit.edu	37	8	6389913	6389913	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr8:6389913C>T	ENST00000325203.5	-	2	858	c.384G>A	c.(382-384)ggG>ggA	p.G128G	ANGPT2_ENST00000523120.1_Silent_p.G128G|MCPH1_ENST00000344683.5_Intron|ANGPT2_ENST00000338312.6_Intron|ANGPT2_ENST00000415216.1_Silent_p.G128G			O15123	ANGP2_HUMAN	angiopoietin 2	128					angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)		ACAGGTTTGTCCCTATTTCTA	0.448000													16	50					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109690214	109690214	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:109690214G>C	ENST00000277225.5	+	3	4310	c.4021G>C	c.(4021-4023)Gat>Cat	p.D1341H	ZNF462_ENST00000441147.2_Missense_Mutation_p.D186H|ZNF462_ENST00000457913.1_Missense_Mutation_p.D1341H			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1341					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						ACACTATGTTGATTACACCTA	0.542000													26	110					0	0	1	0	0
GLS	2744	broad.mit.edu	37	2	191769883	191769883	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:191769883G>C	ENST00000320717.3	+	6	1227	c.969G>C	c.(967-969)ttG>ttC	p.L323F	GLS_ENST00000338435.4_Missense_Mutation_p.L323F	NM_014905.4	NP_055720.3	O94925	GLSK_HUMAN	glutaminase	323					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity	p.L323L(1)		breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AACTATTTTTGAATGAAGATG	0.294000													5	31					0	0	1	0	0
SCARF1	8578	broad.mit.edu	37	17	1538399	1538399	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:1538399G>A	ENST00000263071.4	-	11	2195	c.2146C>T	c.(2146-2148)Cag>Tag	p.Q716*	SCARF1_ENST00000348987.3_Nonsense_Mutation_p.Q630*|SCARF1_ENST00000571272.1_3'UTR	NM_003693.2|NM_145350.1	NP_003684.2|NP_663325.1	Q14162	SREC_HUMAN	scavenger receptor class F, member 1	716	Gly-rich.				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			cervix(1)|endometrium(3)|kidney(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TGGCCTTTCTGGAAGCTACCA	0.637000													23	23					0	0	1	0	0
MVD	4597	broad.mit.edu	37	16	88719778	88719778	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:88719778G>A	ENST00000301012.3	-	9	1081	c.1052C>T	c.(1051-1053)tCa>tTa	p.S351L		NM_002461.1	NP_002452.1	P53602	MVD1_HUMAN	mevalonate (diphospho) decarboxylase	351					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity			endometrium(3)|large_intestine(1)|lung(7)|ovary(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.0478)		AAGCTCAGCTGAGAGAGGGGC	0.612000													4	11					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767094	57767094	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr20:57767094G>A	ENST00000371030.2	+	1	1020	c.1020G>A	c.(1018-1020)gaG>gaA	p.E340E		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	340						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GGAAGTGTGAGAGCACCGACT	0.736000													3	18					0	0	1	0	0
ZNF225	7768	broad.mit.edu	37	19	44635930	44635930	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:44635930C>T	ENST00000262894.6	+	5	1443	c.1163C>T	c.(1162-1164)tCa>tTa	p.S388L	ZNF225_ENST00000590612.1_Missense_Mutation_p.S388L|ZNF225_ENST00000592780.1_3'UTR	NM_013362.2	NP_037494.2	Q9UK10	ZN225_HUMAN	zinc finger protein 225	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	16		Prostate(69;0.0352)|all_neural(266;0.202)				TCAGGTCTTTCAAGACATGTG	0.418000													21	93					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98270475	98270475	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:98270475C>T	ENST00000331920.6	-	1	468	c.169G>A	c.(169-171)Gac>Aac	p.D57N	PTCH1_ENST00000375274.2_Intron|PTCH1_ENST00000430669.2_Intron|PTCH1_ENST00000468211.2_Intron|PTCH1_ENST00000437951.1_Intron	NM_000264.3	NP_000255.2	Q13635	PTC1_HUMAN	patched 1	57					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AAGGCGGCGTCGCAGTAGCTG	0.682000													9	13					0	0	1	0	0
ZNF436	80818	broad.mit.edu	37	1	23689318	23689318	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:23689318C>T	ENST00000314011.4	-	4	693	c.557G>A	c.(556-558)aGa>aAa	p.R186K	ZNF436_ENST00000374608.3_Missense_Mutation_p.R186K	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		AGTATGTGTTCTTTGATGCTG	0.448000													30	146					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94944794	94944794	+	Missense_Mutation	SNP	C	C	A	rs150388378		TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr7:94944794C>A	ENST00000222381.3	-	4	441	c.210G>T	c.(208-210)aaG>aaT	p.K70N	PON1_ENST00000542556.1_Missense_Mutation_p.K70N	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	70					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	TTCCAGGATACTTTAATCCCT	0.428000													18	51					3.99206e-14	4.45466e-14	1	1	0
PGK1	5230	broad.mit.edu	37	X	77378444	77378444	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:77378444G>A	ENST00000373316.4	+	7	921	c.754G>A	c.(754-756)Gag>Aag	p.E252K	PGK1_ENST00000537456.1_Missense_Mutation_p.E224K|PGK1_ENST00000442431.1_Missense_Mutation_p.E116K	NM_000291.3	NP_000282.1	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	252			E -> A (in PGK1D; with chronic hemolytic anemia; variant Antwerp).		gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	24						CAACAACATGGAGGTAGGAAA	0.388000													7	61					0	0	1	0	0
GTF2I	2969	broad.mit.edu	37	7	74148279	74148279	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr7:74148279A>G	ENST00000324896.4	+	16	1708	c.1319A>G	c.(1318-1320)aAt>aGt	p.N440S	GTF2I_ENST00000416070.1_Missense_Mutation_p.N399S|GTF2I_ENST00000353920.4_Missense_Mutation_p.N420S|GTF2I_ENST00000346152.4_Missense_Mutation_p.N419S	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi	440					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.N440S(7)		NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						GAGCTTCTGAATTCAACACGT	0.358000													4	149					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40113086	40113086	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr20:40113086G>A	ENST00000373233.3	-	15	2340	c.2163C>T	c.(2161-2163)ttC>ttT	p.F721F	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	721					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CCTTGGTCAGGAAGGAAAAGT	0.468000													27	129					0	0	1	0	0
LCE2A	353139	broad.mit.edu	37	1	152671499	152671499	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:152671499C>G	ENST00000368779.1	+	2	173	c.122C>G	c.(121-123)tCt>tGt	p.S41C		NM_178428.3	NP_848515.1	Q5TA79	LCE2A_HUMAN	late cornified envelope 2A	41	Cys-rich.				keratinization					breast(1)|large_intestine(1)|liver(2)|lung(4)	8	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCCAGTCTCTTCCTGCTGT	0.687000													40	82					0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31236988	31236988	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:31236988G>A	ENST00000251758.5	+	3	637	c.386G>A	c.(385-387)cGa>cAa	p.R129Q	DDX11_ENST00000545668.1_Missense_Mutation_p.R129Q|DDX11_ENST00000350437.4_Missense_Mutation_p.R129Q|DDX11_ENST00000542838.1_Missense_Mutation_p.R129Q|DDX11_ENST00000407793.2_Missense_Mutation_p.R129Q|DDX11_ENST00000228264.6_Missense_Mutation_p.R103Q			Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	129	Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CTGGTGGACCGACTAAAGGTG	0.587000										Multiple Myeloma(12;0.14)			10	51					0	0	1	0	0
CARNS1	57571	broad.mit.edu	37	11	67192061	67192061	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr11:67192061C>G	ENST00000445895.2	+	9	2956	c.2842C>G	c.(2842-2844)Cac>Gac	p.H948D	CARNS1_ENST00000307823.3_Missense_Mutation_p.H825D|CARNS1_ENST00000531040.1_Missense_Mutation_p.H922D|CARNS1_ENST00000423745.2_Missense_Mutation_p.H825D			A5YM72	CRNS1_HUMAN	carnosine synthase 1	825					carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)	11						CTTCCTGTCTCACTTCAAATA	0.662000													4	22					0	0	1	0	0
LIMA1	51474	broad.mit.edu	37	12	50570878	50570878	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:50570878C>T	ENST00000547825.1	-	5	2612	c.1343G>A	c.(1342-1344)cGg>cAg	p.R448Q	LIMA1_ENST00000394943.3_Missense_Mutation_p.R751Q|LIMA1_ENST00000552909.1_Missense_Mutation_p.R589Q|LIMA1_ENST00000552491.1_Missense_Mutation_p.R447Q|LIMA1_ENST00000552823.1_Missense_Mutation_p.R590Q|LIMA1_ENST00000341247.4_Missense_Mutation_p.R750Q|LIMA1_ENST00000552783.1_Missense_Mutation_p.R591Q	NM_001243775.1	NP_001230704.1	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1	750	LIM zinc-binding.				actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding	p.R750L(1)		NS(1)|breast(4)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(2)	44						ATCATAATACCGATTTCTCTT	0.428000													4	260					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62397082	62397082	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr11:62397082G>C	ENST00000346178.4	-	16	1893	c.1878C>G	c.(1876-1878)ttC>ttG	p.F626L	GANAB_ENST00000356638.3_Missense_Mutation_p.F604L|GANAB_ENST00000540933.1_Missense_Mutation_p.F507L|GANAB_ENST00000534779.1_Missense_Mutation_p.F512L	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	604					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						AGCCAGCGAAGAAGGCCCTGG	0.602000													10	31					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123224564	123224564	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:123224564G>A	ENST00000371160.1	+	31	3707	c.3417G>A	c.(3415-3417)atG>atA	p.M1139I	STAG2_ENST00000354548.5_Missense_Mutation_p.M1070I|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000218089.9_Missense_Mutation_p.M1139I|STAG2_ENST00000371157.3_Missense_Mutation_p.M1139I|STAG2_ENST00000371145.3_Missense_Mutation_p.M1139I|STAG2_ENST00000371144.3_Missense_Mutation_p.M1139I	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	1139					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						ATAGCTTCATGAGTGTTTATC	0.378000													13	99					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12345547	12345547	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr11:12345547G>A	ENST00000256186.2	+	5	1856	c.1565G>A	c.(1564-1566)aGa>aAa	p.R522K		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	522					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		CTTAGAAGAAGAAAGAAGCTA	0.343000													14	36					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33579079	33579079	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:33579079G>C	ENST00000228567.3	-	2	799	c.503C>G	c.(502-504)tCa>tGa	p.S168*	SYT10_ENST00000535526.1_De_novo_Start_OutOfFrame|SYT10_ENST00000567656.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	168						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity	p.S168*(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTACCGGGTTGATGACGTAGG	0.403000													27	135					0	0	1	0	0
LOC441666	441666	broad.mit.edu	37	10	42832541	42832541	+	RNA	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr10:42832541C>T	ENST00000609841.1	-	0	1362					NR_024380.1																						AAAGGCTTTACCACATTCTTC	0.368000													3	8					0	0	1	0	0
EFNA2	1943	broad.mit.edu	37	19	1295653	1295653	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:1295653G>A	ENST00000215368.2	+	2	265	c.250G>A	c.(250-252)Gag>Aag	p.E84K	MUM1_ENST00000344663.3_Intron	NM_001405.3	NP_001396.2	O43921	EFNA2_HUMAN	ephrin-A2	84					cell-cell signaling	anchored to membrane|plasma membrane	ephrin receptor binding			lung(2)	2		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGCCGGCCGAGCGCATGGA	0.692000													5	16					0	0	1	0	0
CACNG7	59284	broad.mit.edu	37	19	54445440	54445440	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:54445440C>T	ENST00000391767.1	+	6	933	c.721C>T	c.(721-723)Cgg>Tgg	p.R241W	CACNG7_ENST00000222212.2_Missense_Mutation_p.R241W			P62955	CCG7_HUMAN	calcium channel, voltage-dependent, gamma subunit 7	241				GAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQF LQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHIST SPC -> VTSVGPRL (in Ref. 1; AAK20030).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		GCGCCGCGGCCGGAGCCCCTC	0.667000													10	58					0	0	1	0	0
SLC39A10	57181	broad.mit.edu	37	2	196545595	196545595	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:196545595C>G	ENST00000409086.3	+	2	1104	c.829C>G	c.(829-831)Cat>Gat	p.H277D	SLC39A10_ENST00000359634.5_Missense_Mutation_p.H277D|SLC39A10_ENST00000541054.1_Intron	NM_001127257.1	NP_001120729.1	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter), member 10	277					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(16)|pancreas(1)|prostate(1)|skin(2)	34			OV - Ovarian serous cystadenocarcinoma(117;0.221)			TAACCCAGGTCATTCTCATGT	0.438000													7	59					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84050202	84050202	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:84050202C>T	ENST00000299709.3	-	8	1083	c.1084G>A	c.(1084-1086)Gcg>Acg	p.A362T		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	362					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						ATAAACAGCGCCATGGCGAGC	0.637000													10	29					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241702642	241702642	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:241702642G>A	ENST00000498729.2	-	21	2136	c.1890C>T	c.(1888-1890)ttC>ttT	p.F630F	KIF1A_ENST00000320389.7_Silent_p.F621F	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	621					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CACGCTGGGCGAAGGCCCAGT	0.667000													3	13					0	0	1	0	0
KPNA6	23633	broad.mit.edu	37	1	32620298	32620298	+	Silent	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:32620298C>G	ENST00000373625.3	+	2	207	c.114C>G	c.(112-114)ctC>ctG	p.L38L	KPNA6_ENST00000545542.1_Silent_p.L43L|KPNA6_ENST00000537234.1_Silent_p.L35L|KPNA6_ENST00000469790.1_3'UTR	NM_012316.4	NP_036448.1	O60684	IMA7_HUMAN	karyopherin alpha 6 (importin alpha 7)	38	IBB.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			large_intestine(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GCATTCAGCTCCGGAAGCAGA	0.468000													7	19					0	0	1	0	0
CLCN5	1184	broad.mit.edu	37	X	49856837	49856837	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:49856837G>A	ENST00000376088.3	+	15	3053	c.2412G>A	c.(2410-2412)caG>caA	p.Q804Q	CLCN5_ENST00000376091.3_Silent_p.Q804Q|CLCN5_ENST00000376108.3_Silent_p.Q734Q|CLCN5_ENST00000307367.2_Silent_p.Q734Q	NM_001127898.1|NM_001127899.1	NP_001121370.1|NP_001121371.1	P51795	CLCN5_HUMAN	chloride channel, voltage-sensitive 5	734					excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)	30	Ovarian(276;0.236)					ATATAGCACAGATGGCGAACC	0.348000													11	57					0	0	1	0	0
CCNJL	79616	broad.mit.edu	37	5	159680592	159680592	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:159680592C>T	ENST00000393977.3	-	7	1386	c.1101G>A	c.(1099-1101)ggG>ggA	p.G367G	CCNJL_ENST00000257536.7_Silent_p.G319G|CCNJL_ENST00000377503.2_5'UTR	NM_024565.5	NP_078841.3	Q8IV13	CCNJL_HUMAN	cyclin J-like	367						nucleus				endometrium(2)|kidney(5)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGAGCAGGCTCCCTGAACGGT	0.657000													5	28					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24583000	24583000	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:24583000G>C	ENST00000319715.4	+	18	5045	c.4613G>C	c.(4612-4614)aGa>aCa	p.R1538T	RBBP6_ENST00000381039.3_Missense_Mutation_p.R698T|RBBP6_ENST00000348022.2_Missense_Mutation_p.R1504T	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1538	Interaction with p53 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		AGTCCCTCAAGAGACAGAAAA	0.368000													17	55					0	0	1	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64129188	64129188	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr11:64129188C>T	ENST00000528057.1	+	7	814	c.726C>T	c.(724-726)ggC>ggT	p.G242G	RPS6KA4_ENST00000334205.4_Silent_p.G242G|RPS6KA4_ENST00000294261.4_Silent_p.G242G	NM_001006944.1	NP_001006945.1	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 4	242	Protein kinase 1.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			breast(1)|endometrium(3)|lung(7)|ovary(1)|prostate(1)	13						CCCTGGAGGGCGAGAGGAACA	0.711000													7	20					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137488425	137488425	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:137488425C>T	ENST00000254900.5	-	21	2973	c.2602G>A	c.(2602-2604)Gat>Aat	p.D868N		NM_139199.1	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	868					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TGTTCAGAATCCAGCCAAACC	0.453000													27	68					0	0	1	0	0
RNPEPL1	57140	broad.mit.edu	37	2	241513629	241513629	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:241513629C>T	ENST00000270357.4	+	5	938	c.345C>T	c.(343-345)ttC>ttT	p.F115F		NM_018226.4	NP_060696.4	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like 1						leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	13		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		GCGATGAGTTCCTGGTCATCG	0.597000													6	35					0	0	1	0	0
UTP14C	9724	broad.mit.edu	37	13	52603963	52603963	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr13:52603963G>C	ENST00000521776.2	+	2	1756	c.1023G>C	c.(1021-1023)gaG>gaC	p.E341D		NM_021645.5	NP_067677.4	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	341					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				breast(4)|cervix(1)|endometrium(1)|large_intestine(10)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	32		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		TAGCCTCTGAGAGTGAGGAAG	0.507000													21	54					0	0	1	0	0
MAP2K5	5607	broad.mit.edu	37	15	67938757	67938757	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr15:67938757G>T	ENST00000178640.5	+	11	1313	c.686G>T	c.(685-687)gGa>gTa	p.G229V	MAP2K5_ENST00000395476.2_Missense_Mutation_p.G229V|MAP2K5_ENST00000354498.5_Missense_Mutation_p.G193V|MAP2K5_ENST00000560591.1_3'UTR|MAP2K5_ENST00000340972.4_Missense_Mutation_p.G39V	NM_145160.2	NP_660143.1	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	229	Protein kinase.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|skin(1)	16						GGATTTTATGGAGCATTTTTT	0.284000													8	38					7.48243e-07	8.03897e-07	1	1	0
TTN	7273	broad.mit.edu	37	2	179600731	179600731	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:179600731G>A	ENST00000589042.1	-	50	14666	c.14442C>T	c.(14440-14442)ttC>ttT	p.F4814F	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.F4497F|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Silent_p.F3570F|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4497	Ig-like 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTGCAGATGAACTTGGCTG	0.458000													12	42					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48818437	48818437	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr15:48818437C>T	ENST00000316623.5	-	9	1333	c.878G>A	c.(877-879)aGc>aAc	p.S293N		NM_000138.4	NP_000129	P35555	FBN1_HUMAN	fibrillin 1	293	EGF-like 5; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGGAATGGTGCTGCATTCATC	0.393000													11	65					0	0	1	0	0
ZNF217	7764	broad.mit.edu	37	20	52193765	52193765	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr20:52193765G>C	ENST00000371471.2	-	4	1963	c.1538C>G	c.(1537-1539)tCt>tGt	p.S513C	ZNF217_ENST00000302342.3_Missense_Mutation_p.S513C			O75362	ZN217_HUMAN	zinc finger protein 217	513					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			ATACCTCAGAGATGTCTTCTG	0.393000													48	130					0	0	1	0	0
GRTP1	79774	broad.mit.edu	37	13	114009698	114009698	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr13:114009698A>T	ENST00000375430.4	-	3	326	c.280T>A	c.(280-282)Tac>Aac	p.Y94N	GRTP1-AS1_ENST00000419199.1_RNA|GRTP1-AS1_ENST00000423246.1_RNA|GRTP1_ENST00000326039.3_Missense_Mutation_p.Y16N|GRTP1_ENST00000375431.4_Missense_Mutation_p.Y94N			Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	94	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			TGGTGGTAGTAGCCGGGATTC	0.667000													9	26					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7548851	7548851	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:7548851G>A	ENST00000313599.3	-	8	1947	c.1890C>T	c.(1888-1890)atC>atT	p.I630I	CD163L1_ENST00000416109.2_Silent_p.I640I|CD163L1_ENST00000396630.1_Silent_p.I630I			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	630	SRCR 6.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CCATGCCAATGATAGAAGATG	0.502000													8	68					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76440786	76440786	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:76440786C>T	ENST00000389840.5	-	71	11510	c.11386G>A	c.(11386-11388)Gag>Aag	p.E3796K	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.E3805K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ATCTCCTTCTCGGGGGCTTCC	0.567000													11	21					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124522515	124522515	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:124522515G>T	ENST00000408936.3	+	6	1149	c.967G>T	c.(967-969)Ggc>Tgc	p.G323C	DAB2IP_ENST00000309989.1_Missense_Mutation_p.G199C|DAB2IP_ENST00000259371.2_Missense_Mutation_p.G295C			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	323					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						GGGCGGCAAGGGCCCTGGACC	0.617000													10	10					0.000442599	0.000458469	1	1	0
KIF21A	55605	broad.mit.edu	37	12	39734071	39734071	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:39734071G>A	ENST00000395670.3	-	16	2625	c.2206C>T	c.(2206-2208)Caa>Taa	p.Q736*	KIF21A_ENST00000361418.5_Nonsense_Mutation_p.Q736*|KIF21A_ENST00000541463.2_Nonsense_Mutation_p.Q723*|KIF21A_ENST00000361961.3_Nonsense_Mutation_p.Q723*|KIF21A_ENST00000544797.2_Nonsense_Mutation_p.Q723*			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	736					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TGAGCTGCTTGAAGTCTCTGC	0.358000													4	67					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975977	20975977	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:20975977G>A	ENST00000261383.3	-	53	9228	c.9229C>T	c.(9229-9231)Cgc>Tgc	p.R3077C	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3077	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.R3077C(2)		NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AAGGCCCAGCGTCTGGAATTG	0.483000													21	44					0	0	1	0	0
ADAM17	6868	broad.mit.edu	37	2	9630449	9630449	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:9630449C>G	ENST00000310823.3	-	19	2514	c.2332G>C	c.(2332-2334)Gag>Cag	p.E778Q	IAH1_ENST00000545602.1_Intron	NM_003183.4	NP_003174.3	P78536	ADA17_HUMAN	ADAM metallopeptidase domain 17	778					B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			breast(1)|cervix(4)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	28	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		GGGTCCTTCTCAAACCCATCC	0.537000													20	31					0	0	1	0	0
CHML	1122	broad.mit.edu	37	1	241797911	241797911	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:241797911G>A	ENST00000366553.1	-	1	1321	c.1158C>T	c.(1156-1158)ccC>ccT	p.P386P	OPN3_ENST00000469376.1_Intron|OPN3_ENST00000366554.2_Intron|OPN3_ENST00000331838.5_Intron	NM_001821.3	NP_001812.2	P26374	RAE2_HUMAN	choroideremia-like (Rab escort protein 2)	386					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(4)|skin(3)|stomach(1)	26	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			AGAAACCCTGGGGAATTTCTC	0.423000													11	66					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22890989	22890989	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr22:22890989G>A	ENST00000543184.1	-	5	1892	c.1030C>T	c.(1030-1032)Cag>Tag	p.Q344*	PRAME_ENST00000402697.1_Nonsense_Mutation_p.Q344*|PRAME_ENST00000424204.2_Nonsense_Mutation_p.Q328*|PRAME_ENST00000398741.1_Nonsense_Mutation_p.Q344*|PRAME_ENST00000405655.3_Nonsense_Mutation_p.Q344*|PRAME_ENST00000398743.2_Nonsense_Mutation_p.Q344*|PRAME_ENST00000539862.1_Nonsense_Mutation_p.Q328*	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	344					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		CTGGGACTCTGGGACAGATGC	0.537000													37	64					0	0	1	0	0
RNASEL	6041	broad.mit.edu	37	1	182551220	182551220	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:182551220C>T	ENST00000367559.3	-	4	1993	c.1740G>A	c.(1738-1740)ctG>ctA	p.L580L	RNASEL_ENST00000539397.1_Silent_p.L580L|RNASEL_ENST00000444138.1_Silent_p.L580L	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	580	Protein kinase.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						GATGACCCAGCAGGTCACTCA	0.498000													31	93					0	0	1	0	0
TIPIN	54962	broad.mit.edu	37	15	66633668	66633668	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr15:66633668C>G	ENST00000261881.4	-	7	587	c.502G>C	c.(502-504)Gat>Cat	p.D168H	TIPIN_ENST00000367709.4_Missense_Mutation_p.D67H	NM_017858.2	NP_060328	Q9BVW5	TIPIN_HUMAN	TIMELESS interacting protein	168					cell division|DNA replication checkpoint|intra-S DNA damage checkpoint|mitosis|positive regulation of cell proliferation|regulation of DNA replication involved in S phase|replication fork protection	cytoplasm|nuclear chromatin	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	7						GAAGTGACATCATGTTCATTA	0.358000													13	26					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	116930187	116930187	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:116930187C>T	ENST00000356083.3	+	3	743	c.352C>T	c.(352-354)Cgc>Tgc	p.R118C		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	118	Laminin G-like.|TSP N-terminal.				cell adhesion		extracellular matrix structural constituent	p.R118S(1)		central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						CTTCGCTGTCCGCAGCCAGAA	0.662000													23	24					0	0	1	0	0
TRMT2A	27037	broad.mit.edu	37	22	20104414	20104414	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr22:20104414C>G	ENST00000252136.7	-	1	404	c.16G>C	c.(16-18)Gac>Cac	p.D6H	RANBP1_ENST00000430524.1_Intron|TRMT2A_ENST00000404751.3_Missense_Mutation_p.D6H|TRMT2A_ENST00000439169.2_Missense_Mutation_p.D6H|TRMT2A_ENST00000403707.3_Missense_Mutation_p.D6H	NM_001257994.1|NM_022727.5|NM_182984.4	NP_001244923.1|NP_073564.3|NP_892029.2	Q8IZ69	TRM2A_HUMAN	tRNA methyltransferase 2 homolog A (S. cerevisiae)	6					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(2)|endometrium(2)|lung(5)	9						ACCTCGTTGTCGAGGTTCTCA	0.662000													7	9					0	0	1	0	0
CKMT2	1160	broad.mit.edu	37	5	80548609	80548609	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:80548609A>C	ENST00000424301.2	+	4	486	c.248A>C	c.(247-249)aAc>aCc	p.N83T	CKMT2-AS1_ENST00000511495.1_RNA|CKMT2-AS1_ENST00000502041.2_RNA|CKMT2-AS1_ENST00000512287.1_RNA|CKMT2-AS1_ENST00000503483.2_RNA|CKMT2_ENST00000254035.4_Missense_Mutation_p.N83T|CKMT2-AS1_ENST00000501927.2_RNA|CKMT2-AS1_ENST00000505295.1_RNA|CKMT2-AS1_ENST00000500148.2_RNA|CKMT2_ENST00000437669.1_Missense_Mutation_p.N83T	NM_001825.2	NP_001816.2	P17540	KCRS_HUMAN	creatine kinase, mitochondrial 2 (sarcomeric)	83	Phosphagen kinase N-terminal.				creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(4)|urinary_tract(1)	17		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	GTGACACCCAACGGCTACACG	0.587000													12	23					0	0	1	0	0
PLK4	10733	broad.mit.edu	37	4	128811355	128811355	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr4:128811355G>T	ENST00000270861.5	+	7	2068	c.1794G>T	c.(1792-1794)agG>agT	p.R598S	PLK4_ENST00000514379.1_Missense_Mutation_p.R557S|PLK4_ENST00000515069.1_Missense_Mutation_p.R520S|PLK4_ENST00000507249.1_Missense_Mutation_p.R564S|PLK4_ENST00000513090.1_Missense_Mutation_p.R566S	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	598					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						TTGCTCACAGGTTAAAACCAA	0.383000													28	50					4.59853e-10	5.10948e-10	1	1	0
KIF18A	81930	broad.mit.edu	37	11	28112259	28112259	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr11:28112259C>T	ENST00000263181.6	-	5	894	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K		NM_031217.3	NP_112494.3	Q8NI77	KI18A_HUMAN	kinesin family member 18A	202	Kinesin-motor.				blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	36						TGTAAAATTTCTTCTGAGGAT	0.303000													20	21					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501317	90501317	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:90501317C>A	ENST00000325643.5	+	4	1981	c.1915C>A	c.(1915-1917)Cag>Aag	p.Q639K		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CCACCAGGAGCAGTCCTGTGG	0.632000													19	25					2.4624e-09	2.72435e-09	1	1	0
THAP4	51078	broad.mit.edu	37	2	242572549	242572549	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:242572549G>A	ENST00000407315.1	-	2	1454	c.1023C>T	c.(1021-1023)ctC>ctT	p.L341L		NM_015963.5	NP_057047.4	Q8WY91	THAP4_HUMAN	THAP domain containing 4	341							DNA binding|metal ion binding			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	9		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		GTGAGTCGATGAGCTTGCAGG	0.627000													7	26					0	0	1	0	0
PTPN11	5781	broad.mit.edu	37	12	112915528	112915528	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:112915528C>G	ENST00000351677.2	+	8	1125	c.927C>G	c.(925-927)atC>atG	p.I309M	PTPN11_ENST00000392597.1_Missense_Mutation_p.I309M	NM_002834.3	NP_002825.3	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type 11	309	Tyrosine-protein phosphatase.		I -> V (in NS1).		axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(406)|kidney(2)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(3)|stomach(3)	451						ATGCAAATATCATCATGGTAA	0.378000			Mis		"""JMML, AML, MDS"""		Noonan Syndrome		Noonan syndrome				20	54					0	0	1	0	0
NBPF9	400818	broad.mit.edu	37	1	144828704	144828704	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:144828704T>G	ENST00000338347.4	+	14	1750	c.1750T>G	c.(1750-1752)Tac>Gac	p.Y584D	NBPF9_ENST00000281815.8_Missense_Mutation_p.Y182D|NBPF9_ENST00000468645.1_3'UTR|NBPF9_ENST00000440491.2_3'UTR					neuroblastoma breakpoint family, member 9									p.L657L(3)|p.Y584D(1)		NS(2)|prostate(1)	3						CTTCGCCCTTTACGTGGACAA	0.438000													5	343					0	0	1	0	0
PIWIL4	143689	broad.mit.edu	37	11	94353178	94353178	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr11:94353178G>A	ENST00000299001.6	+	19	2521	c.2310G>A	c.(2308-2310)ctG>ctA	p.L770L	RP11-867G2.8_ENST00000536540.1_RNA|RP11-867G2.8_ENST00000537874.1_RNA|PIWIL4_ENST00000537419.1_Silent_p.L121L	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	770	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ACTTTTATCTGATCAGCCAGG	0.428000													18	24					0	0	1	0	0
TAOK3	51347	broad.mit.edu	37	12	118627629	118627629	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:118627629T>C	ENST00000392533.3	-	14	1802	c.1312A>G	c.(1312-1314)Atc>Gtc	p.I438V	TAOK3_ENST00000419821.2_Missense_Mutation_p.I438V|TAOK3_ENST00000537952.1_5'UTR	NM_016281.3	NP_057365.3	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	438					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)|skin(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTGATTTGATCGTGGCAAAG	0.627000													18	81					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49176871	49176871	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:49176871C>T	ENST00000307885.4	-	1	1041	c.347G>A	c.(346-348)cGa>cAa	p.R116Q	ADCY6_ENST00000550422.1_Missense_Mutation_p.R116Q|ADCY6_ENST00000357869.3_Missense_Mutation_p.R116Q	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	116					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						CCAGCAGGATCGCCCACTCCT	0.672000													15	30					0	0	1	0	0
SEC24A	10802	broad.mit.edu	37	5	134033704	134033704	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:134033704G>A	ENST00000398844.2	+	15	2511	c.2223G>A	c.(2221-2223)cgG>cgA	p.R741R		NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	741					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACCTTACTCGGAAGATTGGCT	0.393000													38	76					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	141015991	141015991	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:141015991G>A	ENST00000277549.5	+	47	6711	c.4142G>A	c.(4141-4143)cGg>cAg	p.R1381Q	CACNA1B_ENST00000371372.1_Missense_Mutation_p.R2187Q|CACNA1B_ENST00000277551.2_Intron|CACNA1B_ENST00000371355.4_Missense_Mutation_p.R2188Q|CACNA1B_ENST00000371363.1_Missense_Mutation_p.R2185Q|CACNA1B_ENST00000371357.1_Missense_Mutation_p.R2186Q			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	2187					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CGCGGTGGGCGGAGGCAGCTC	0.632000													3	4					0	0	1	0	0
PPP1R3C	5507	broad.mit.edu	37	10	93390097	93390097	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr10:93390097C>G	ENST00000238994.5	-	2	625	c.541G>C	c.(541-543)Gag>Cag	p.E181Q		NM_005398.5	NP_005389.1	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory subunit 3C	181	CBM21.|Interaction with EPM2A.						protein serine/threonine phosphatase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(1)	12		Colorectal(252;0.235)				ACTTTCTTCTCAAAACTCACA	0.413000													13	90					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													3	52					0	0	1	0	0
NUP85	79902	broad.mit.edu	37	17	73221213	73221213	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:73221213C>T	ENST00000447371.2	+	7	533	c.109C>T	c.(109-111)Ctg>Ttg	p.L37L	NUP85_ENST00000541827.1_Silent_p.L159L|NUP85_ENST00000579298.1_Intron|NUP85_ENST00000245544.4_Silent_p.L205L|NUP85_ENST00000579324.1_Silent_p.L93L|NUP85_ENST00000449421.2_3'UTR			Q9BW27	NUP85_HUMAN	nucleoporin 85kDa	205					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	16	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			CATCTTGGTGCTGCAGGGCCG	0.652000													23	31					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113314631	113314631	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:113314631G>A	ENST00000389385.4	+	13	1628	c.1131G>A	c.(1129-1131)gaG>gaA	p.E377E	RPH3A_ENST00000551052.1_Silent_p.E373E|RPH3A_ENST00000415485.3_Silent_p.E377E|RPH3A_ENST00000447659.2_Silent_p.E328E|RPH3A_ENST00000543106.2_Silent_p.E377E|RPH3A_ENST00000420983.2_Silent_p.E377E|RPH3A_ENST00000549913.2_3'UTR|RPH3A_ENST00000548866.1_Silent_p.E328E	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	377					intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		CCCCAGAGGAGGAGGAAGAGG	0.597000													7	33					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21557868	21557868	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr13:21557868C>G	ENST00000382592.4	-	5	2382	c.1977G>C	c.(1975-1977)aaG>aaC	p.K659N	LATS2_ENST00000542899.1_Missense_Mutation_p.K659N	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	659					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		TCTTGGCCCTCTTTAACCTGT	0.493000													17	53					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140074760	140074760	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:140074760G>A	ENST00000323927.2	-	10	1767	c.1763C>T	c.(1762-1764)cCg>cTg	p.P588L		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	588					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		GACCCCGAACGGTGGCTGCTC	0.642000													7	140					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49177002	49177002	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:49177002C>T	ENST00000307885.4	-	1	910	c.216G>A	c.(214-216)cgG>cgA	p.R72R	ADCY6_ENST00000550422.1_Silent_p.R72R|ADCY6_ENST00000357869.3_Silent_p.R72R	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	72					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						GGCCGCCCCTCCGGATGAAGG	0.721000													12	17					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8974089	8974089	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:8974089C>G	ENST00000397910.4	-	76	42785	c.42582G>C	c.(42580-42582)caG>caC	p.Q14194H	MUC16_ENST00000596956.1_5'UTR|MUC16_ENST00000380951.5_Missense_Mutation_p.Q835H	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14225	SEA 14.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGATAAATTCTGGGGTGCAT	0.488000													4	14					0	0	1	0	0
OR2T5	401993	broad.mit.edu	37	1	248651988	248651988	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:248651988G>A	ENST00000366473.2	+	1	104	c.99G>A	c.(97-99)gtG>gtA	p.V33V		NM_001004697.1	NP_001004697.1	Q6IEZ7	OR2T5_HUMAN	olfactory receptor, family 2, subfamily T, member 5	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(2)|pancreas(1)|skin(2)	9	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TACTTAGTGTGGTCATCTTTG	0.488000													11	172					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8375060	8375060	+	Silent	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:8375060G>C	ENST00000538603.1	-	7	1311	c.753C>G	c.(751-753)ctC>ctG	p.L251L	FAM90A1_ENST00000307435.6_Silent_p.L251L	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	251							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		TGACGGCCTGGAGCAGGCCGT	0.662000													17	24					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16504433	16504433	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr4:16504433G>A	ENST00000304523.5	-	8	1278	c.955C>T	c.(955-957)Cta>Tta	p.L319L	RP11-446J8.1_ENST00000512370.1_RNA|LDB2_ENST00000515064.1_Silent_p.L317L|LDB2_ENST00000441778.2_3'UTR|LDB2_ENST00000502640.1_3'UTR|LDB2_ENST00000503178.2_3'UTR	NM_001290.3	NP_001281.1	O43679	LDB2_HUMAN	LIM domain binding 2	319	LIM-binding domain (LID) (By similarity).						LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						CTAGTGATTAGCCTTTCGTCC	0.517000													39	72					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73477856	73477856	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:73477856A>T	ENST00000377110.3	-	3	673	c.430T>A	c.(430-432)Ttc>Atc	p.F144I	TRPM3_ENST00000360823.2_5'UTR|TRPM3_ENST00000377105.1_5'UTR|TRPM3_ENST00000377111.2_Missense_Mutation_p.F144I|TRPM3_ENST00000377106.1_5'UTR|TRPM3_ENST00000396283.1_5'UTR|TRPM3_ENST00000377097.3_5'UTR|TRPM3_ENST00000423814.3_Missense_Mutation_p.F146I|TRPM3_ENST00000377101.1_5'UTR|TRPM3_ENST00000361823.5_5'UTR|TRPM3_ENST00000357533.2_Missense_Mutation_p.F146I|TRPM3_ENST00000437699.3_5'UTR			Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3							integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						CCTCCTTGGAACTCAATGGTC	0.478000													48	45					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756574	94756574	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr14:94756574C>T	ENST00000554723.1	-	2	895	c.477G>A	c.(475-477)ccG>ccA	p.P159P	SERPINA10_ENST00000261994.4_Silent_p.P119P|SERPINA10_ENST00000554173.1_Silent_p.P119P|SERPINA10_ENST00000393096.1_Silent_p.P119P			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	119					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		GGGTTTCAGTCGGCCCTGTGG	0.582000													21	58					0	0	1	0	0
MARC2	54996	broad.mit.edu	37	1	220928421	220928421	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:220928421G>A	ENST00000366913.3	+	2	603	c.405G>A	c.(403-405)ttG>ttA	p.L135L	MARC2_ENST00000359316.2_Silent_p.L135L	NM_017898.3	NP_060368.2	Q969Z3	MOSC2_HUMAN	mitochondrial amidoxime reducing component 2	135						mitochondrial outer membrane|peroxisome	molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding										AGCTGGTTTTGCCTAGCAAGC	0.537000													14	88					0	0	1	0	0
RTTN	25914	broad.mit.edu	37	18	67673620	67673620	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr18:67673620C>T	ENST00000255674.6	-	47	6808	c.6522G>A	c.(6520-6522)caG>caA	p.Q2174Q	RTTN_ENST00000454359.1_3'UTR	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	2174							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				AACTGACCTTCTGATAATTGT	0.408000													19	24					0	0	1	0	0
SCARF1	8578	broad.mit.edu	37	17	1538603	1538603	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:1538603G>C	ENST00000263071.4	-	11	1991	c.1942C>G	c.(1942-1944)Ccg>Gcg	p.P648A	SCARF1_ENST00000348987.3_Missense_Mutation_p.P562A|SCARF1_ENST00000571272.1_3'UTR	NM_003693.2|NM_145350.1	NP_003684.2|NP_663325.1	Q14162	SREC_HUMAN	scavenger receptor class F, member 1	648	Gly-rich.				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			cervix(1)|endometrium(3)|kidney(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GCAGCCGCCGGAAAGGACTCG	0.692000													10	12					0	0	1	0	0
SBDS	51119	broad.mit.edu	37	7	66453442	66453442	+	Silent	SNP	T	T	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr7:66453442T>C	ENST00000246868.2	-	5	852	c.669A>G	c.(667-669)ctA>ctG	p.L223L		NM_016038.2	NP_057122.2	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome	223					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			cervix(1)|endometrium(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	7						CCTTTTTTATTAGCTCATCAA	0.383000			Gene Conversion			"""AML, MDS"""			Shwachman-Diamond syndrome				19	55					0	0	1	0	0
FAM134B	54463	broad.mit.edu	37	5	16475169	16475169	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:16475169G>C	ENST00000306320.9	-	9	1261	c.1175C>G	c.(1174-1176)tCa>tGa	p.S392*	FAM134B_ENST00000399793.2_Nonsense_Mutation_p.S251*	NM_001034850.2	NP_001030022.1	Q9H6L5	F134B_HUMAN	family with sequence similarity 134, member B	392					sensory perception of pain	cis-Golgi network|endoplasmic reticulum|integral to membrane				breast(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(1)	16						ACCAGCTGCTGATTGCGTCTC	0.488000													26	62					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224475612	224475612	+	Silent	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:224475612C>G	ENST00000281701.6	-	14	1918	c.1659G>C	c.(1657-1659)ctG>ctC	p.L553L	NVL_ENST00000482491.1_Silent_p.L277L|NVL_ENST00000340871.4_Silent_p.L364L|NVL_ENST00000391875.2_Silent_p.L447L|NVL_ENST00000361463.3_Silent_p.L447L|NVL_ENST00000469075.1_Silent_p.L462L	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	553						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		TGAAATCATTCAGTTCAATGC	0.483000													16	45					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745917	140745917	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:140745917G>T	ENST00000518069.1	+	1	2020	c.2020G>T	c.(2020-2022)Gac>Tac	p.D674Y	PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCCTGGCTGACCTAGGCAG	0.612000													88	191					5.92634e-42	6.72859e-42	1	1	0
TEFM	79736	broad.mit.edu	37	17	29226579	29226579	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:29226579G>A	ENST00000581216.1	-	4	1312	c.691C>T	c.(691-693)Ctg>Ttg	p.L231L	TEFM_ENST00000580840.1_3'UTR	NM_024683.3	NP_078959.3	Q96QE5	TEFM_HUMAN	transcription elongation factor, mitochondrial	231					oxidative phosphorylation|regulation of transcription, DNA-dependent|transcription from mitochondrial promoter	mitochondrial nucleoid|ribonucleoprotein complex	DNA polymerase processivity factor activity|nucleic acid binding|protein binding										GTTTTTTCCAGAACATAGAAA	0.299000													7	110					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56638458	56638458	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:56638458C>G	ENST00000267116.7	-	24	2821	c.2700G>C	c.(2698-2700)gaG>gaC	p.E900D	ANKRD52_ENST00000548241.1_5'UTR	NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	900							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						TCTGCCCGTTCTCAGCCGCCG	0.642000													6	27					0	0	1	0	0
SNRPD2	6633	broad.mit.edu	37	19	46190868	46190868	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:46190868G>A	ENST00000342669.3	-	3	744	c.300C>T	c.(298-300)ttC>ttT	p.F100F	SNRPD2_ENST00000585392.1_Silent_p.F36F|SNRPD2_ENST00000590212.1_3'UTR|SNRPD2_ENST00000391932.3_Silent_p.F90F|SNRPD2_ENST00000587367.1_Silent_p.F90F|SNRPD2_ENST00000588599.1_Silent_p.F90F|SNRPD2_ENST00000588301.1_Silent_p.F100F	NM_004597.5	NP_004588.1	P62316	SMD2_HUMAN	small nuclear ribonucleoprotein D2 polypeptide 16.5kDa	100					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding			breast(1)|large_intestine(1)|lung(2)	4		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00546)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.194)		CCCCGCGCAGGAACATCTTGG	0.562000													9	39					0	0	1	0	0
SMCR8	140775	broad.mit.edu	37	17	18219385	18219385	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:18219385C>T	ENST00000406438.3	+	1	762	c.282C>T	c.(280-282)atC>atT	p.I94I		NM_144775.2	NP_658988.2	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region, candidate 8	94										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21						CCCTGCGTATCATGTCTGTGG	0.527000													27	158					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48809003	48809003	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:48809003G>A	ENST00000309835.3	+	1	1241	c.1231G>A	c.(1231-1233)Gag>Aag	p.E411K	STON1_ENST00000406226.1_Missense_Mutation_p.E411K|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.E411K|STON1_ENST00000404752.1_Missense_Mutation_p.E411K|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.E411K|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.E411K|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.E411K|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.E411K					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AAAGAACTACGAGGAGCAAGA	0.403000													4	78					0	0	1	0	0
CYTH3	9265	broad.mit.edu	37	7	6227307	6227307	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr7:6227307G>A	ENST00000350796.3	-	3	299	c.163C>T	c.(163-165)Cta>Tta	p.L55L		NM_004227.3	NP_004218.1	O43739	CYH3_HUMAN	cytohesin 3	55					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|urinary_tract(1)	19						ACGGAAGTTAGATTGTCGATC	0.428000													19	72					0	0	1	0	0
NR5A2	2494	broad.mit.edu	37	1	200017650	200017650	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:200017650G>C	ENST00000367362.3	+	5	1060	c.814G>C	c.(814-816)Gag>Cag	p.E272Q	NR5A2_ENST00000236914.3_Missense_Mutation_p.E226Q|NR5A2_ENST00000544748.1_Missense_Mutation_p.E200Q	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	272					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					CATCAAGTCTGAGTACCCAGA	0.512000													24	38					0	0	1	0	0
TFE3	7030	broad.mit.edu	37	X	48891044	48891044	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:48891044T>A	ENST00000315869.7	-	8	1331	c.1072A>T	c.(1072-1074)Agg>Tgg	p.R358W	TFE3_ENST00000487451.1_5'UTR	NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	358					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						TTGAATCGCCTGCGACGCTCA	0.532000			T	"""SFPQ, ASPSCR1, PRCC, NONO, CLTC"""	"""papillary renal, alveolar soft part sarcoma, renal"""								12	38					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54578726	54578726	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:54578726G>A	ENST00000336470.4	+	13	1322	c.1183G>A	c.(1183-1185)Ggg>Agg	p.G395R	GNL3L_ENST00000360845.2_Splice_Site_p.G395R	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	395					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						CCAATGCAGCGGGAAGATCAG	0.507000													6	65					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604051	140604051	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:140604051G>T	ENST00000239449.4	+	1	974	c.974G>T	c.(973-975)gGg>gTg	p.G325V	PCDHB14_ENST00000515856.2_Missense_Mutation_p.G172V	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		325	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAGATGGTGGGGGTCTTTCA	0.383000													12	65					2.80697e-09	3.09243e-09	1	1	0
ZNF839	55778	broad.mit.edu	37	14	102807866	102807866	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr14:102807866C>T	ENST00000262236.5	+	8	2147	c.1792C>T	c.(1792-1794)Cct>Tct	p.P598S	ZNF839_ENST00000559185.1_Missense_Mutation_p.P596S|ZNF839_ENST00000558850.1_Missense_Mutation_p.P596S|ZNF839_ENST00000420933.2_3'UTR|ZNF839_ENST00000442396.2_Missense_Mutation_p.P712S	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	596						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						GTCAGGAGAGCCTAGGAGGCT	0.587000													5	17					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697705	6697705	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:6697705G>A	ENST00000245907.6	-	20	2633	c.2541C>T	c.(2539-2541)atC>atT	p.I847I		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	847					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GAACGGCTCGGATTTCCACCT	0.572000													10	32					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11053992	11053992	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:11053992G>A	ENST00000295082.1	+	1	1930	c.1440G>A	c.(1438-1440)ctG>ctA	p.L480L		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	480						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		TCCCCCTCCTGACCGAGGAGA	0.647000													8	22					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47162043	47162043	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr3:47162043C>G	ENST00000409792.3	-	3	4125	c.4083G>C	c.(4081-4083)caG>caC	p.Q1361H		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CCTTGTCTTTCTGAAGGGATA	0.388000			"""N, F, S, Mis"""		clear cell renal carcinoma								18	31					0	0	1	0	0
NEMF	9147	broad.mit.edu	37	14	50267154	50267154	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr14:50267154G>C	ENST00000298310.5	-	23	2805	c.2356C>G	c.(2356-2358)Cac>Gac	p.H786D	NEMF_ENST00000546046.1_Missense_Mutation_p.H765D|NEMF_ENST00000545773.1_Missense_Mutation_p.H744D|NEMF_ENST00000556925.1_5'UTR			O60524	NEMF_HUMAN	nuclear export mediator factor	786						cytoplasm|nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(13)|liver(1)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	36						GGTTGAAGGTGAGACAAGTCA	0.323000													9	24					0	0	1	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171774337	171774337	+	Splice_Site	SNP	C	C	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:171774337C>A	ENST00000311601.5	-	11	1183		c.e11-1		SH3PXD2B_ENST00000519643.1_Splice_Site	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B						adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTTGGTGATCCTATGGAGAAA	0.517000													19	27					5.35267e-07	5.77466e-07	1	1	0
ANKS4B	257629	broad.mit.edu	37	16	21262007	21262007	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:21262007C>G	ENST00000311620.5	+	2	1193	c.1120C>G	c.(1120-1122)Ctg>Gtg	p.L374V		NM_145865.2	NP_665872.2	Q8N8V4	ANS4B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 4B	374	SAM.									NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|lung(11)|ovary(2)	20				GBM - Glioblastoma multiforme(48;0.0565)		TCTAGAAGCTCTGCTGCTCTG	0.502000													29	38					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77776768	77776768	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr8:77776768C>G	ENST00000521891.2	+	11	11266	c.10818C>G	c.(10816-10818)ttC>ttG	p.F3606L	ZFHX4_ENST00000455469.2_Missense_Mutation_p.F3561L|ZFHX4_ENST00000050961.6_Missense_Mutation_p.F3557L|ZFHX4_ENST00000518282.1_Missense_Mutation_p.F3580L	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3557						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATGGTAATTTCAATAGCATCC	0.363000										HNSCC(33;0.089)			10	12					0	0	1	0	0
CCDC96	257236	broad.mit.edu	37	4	7044575	7044575	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr4:7044575T>C	ENST00000310085.4	-	1	153	c.91A>G	c.(91-93)Agc>Ggc	p.S31G	RP11-367J11.2_ENST00000500031.1_RNA	NM_153376.2	NP_699207.1	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	31										endometrium(3)|kidney(1)|large_intestine(3)|lung(2)|skin(1)|urinary_tract(1)	11						GGGCCAGAGCTGGCCTTGATC	0.706000													3	5					0	0	1	0	0
ZNF410	57862	broad.mit.edu	37	14	74376124	74376124	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr14:74376124G>A	ENST00000555044.1	+	8	1188	c.994G>A	c.(994-996)Gtt>Att	p.V332I	RP5-1021I20.5_ENST00000554009.1_RNA|ZNF410_ENST00000540593.1_Missense_Mutation_p.V259I|RP5-1021I20.4_ENST00000556551.2_3'UTR|ZNF410_ENST00000324593.6_Missense_Mutation_p.V332I|ZNF410_ENST00000442160.3_Missense_Mutation_p.V349I|ZNF410_ENST00000412490.3_3'UTR|ZNF410_ENST00000334521.4_Missense_Mutation_p.V279I	NM_001242928.1|NM_021188.2	NP_001229857.1|NP_067011.1	Q86VK4	ZN410_HUMAN	zinc finger protein 410	332					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(234;0.00369)		ACATCTGGTGGTTCACTCAGG	0.408000													90	151					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12302617	12302617	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:12302617G>C	ENST00000358136.3	+	3	275	c.145G>C	c.(145-147)Gaa>Caa	p.E49Q	VPS13D_ENST00000356315.4_Missense_Mutation_p.E49Q	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	49					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGCCTTGAAAGAATTGGAATT	0.353000													4	37					0	0	1	0	0
ARSB	411	broad.mit.edu	37	5	78260297	78260297	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:78260297G>A	ENST00000264914.4	-	3	1168	c.632C>T	c.(631-633)tCa>tTa	p.S211L	ARSB_ENST00000565165.1_Missense_Mutation_p.S211L|ARSB_ENST00000396151.3_Missense_Mutation_p.S211L	NM_000046.3	NP_000037.2	P15848	ARSB_HUMAN	arylsulfatase B	211					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)		TATGTTTGTTGAATACATATT	0.373000													16	36					0	0	1	0	0
FAM83G	644815	broad.mit.edu	37	17	18882043	18882043	+	Silent	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:18882043G>T	ENST00000388995.6	-	5	1159	c.936C>A	c.(934-936)ctC>ctA	p.L312L	SLC5A10_ENST00000395643.2_Intron|FAM83G_ENST00000345041.4_Silent_p.L312L|SLC5A10_ENST00000395642.1_Intron|SLC5A10_ENST00000317977.6_Intron|SLC5A10_ENST00000395647.2_Intron|SLC5A10_ENST00000395645.3_Intron|FAM83G_ENST00000585154.2_Silent_p.L312L|SLC5A10_ENST00000417251.2_Intron			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	312										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						GGATGCCCTTGAGGCTCACAC	0.607000													39	39					4.32679e-17	4.84899e-17	1	1	0
VDAC1	7416	broad.mit.edu	37	5	133326558	133326558	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:133326558G>A	ENST00000265333.3	-	5	555	c.311C>T	c.(310-312)tCa>tTa	p.S104L	VDAC1_ENST00000395044.3_Missense_Mutation_p.S104L|VDAC1_ENST00000466080.1_5'UTR|VDAC1_ENST00000395047.2_Missense_Mutation_p.S104L	NM_003374.2	NP_003365.1	P21796	VDAC1_HUMAN	voltage-dependent anion channel 1	104					apoptosis|interspecies interaction between organisms	mitochondrial nucleoid|mitochondrial outer membrane|plasma membrane|pore complex	porin activity|protein binding|voltage-gated anion channel activity			endometrium(1)|large_intestine(1)|lung(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)		Dihydroxyaluminium(DB01375)	AGTGTTAGGTGAGAAGGATGA	0.463000													12	73					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577127	7577127	+	Missense_Mutation	SNP	C	C	T	rs67389650		TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:7577127C>T	ENST00000420246.2	-	8	943	c.811G>A	c.(811-813)Gag>Aag	p.E271K	TP53_ENST00000269305.4_Missense_Mutation_p.E271K|TP53_ENST00000445888.2_Missense_Mutation_p.E271K|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.E271K|TP53_ENST00000359597.4_Missense_Mutation_p.E271K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	271	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> Q (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(28)|p.E271*(18)|p.0?(8)|p.E271Q(5)|p.?(2)|p.G266_E271delGRNSFE(2)|p.F270fs*72(1)|p.L265_K305del41(1)|p.E271P(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.E271del(1)|p.S269fs*34(1)|p.F270_D281del12(1)|p.E271fs*34(1)|p.E271fs*35(1)|p.E271_R273delEVR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACGCACCTCAAAGCTGTTC	0.537000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	7					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169565266	169565266	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:169565266G>A	ENST00000263686.6	-	12	2035	c.1998C>T	c.(1996-1998)acC>acT	p.T666T	SELP_ENST00000367792.2_Silent_p.T482T|SELP_ENST00000367788.2_Silent_p.T604T|SELP_ENST00000367786.2_Silent_p.T604T|SELP_ENST00000367791.2_Silent_p.T480T|SELP_ENST00000458599.2_Silent_p.T482T|SELP_ENST00000367793.2_Silent_p.T604T|SELP_ENST00000367794.2_Silent_p.T604T	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	666	Sushi 8.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	AGTAACAAGTGGTATTAAAAC	0.517000													88	214					0	0	1	0	0
SUN3	256979	broad.mit.edu	37	7	48033970	48033970	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr7:48033970G>A	ENST00000453192.2	-	9	1010	c.767C>T	c.(766-768)tCa>tTa	p.S256L	SUN3_ENST00000297325.4_Missense_Mutation_p.S268L|SUN3_ENST00000395572.2_Missense_Mutation_p.S268L|SUN3_ENST00000412142.1_Missense_Mutation_p.S168L|SUN3_ENST00000473723.1_5'UTR	NM_001284350.1	NP_001271279.1	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 3	268	SUN.					integral to membrane				central_nervous_system(1)|endometrium(3)|large_intestine(8)|liver(1)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CACCTTCTCTGAGATGTGCTC	0.453000													38	74					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67400955	67400955	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:67400955C>T	ENST00000329956.6	+	8	809	c.790C>T	c.(790-792)Cga>Tga	p.R264*	LRRC36_ENST00000563189.1_Nonsense_Mutation_p.R143*|LRRC36_ENST00000541146.1_Intron|LRRC36_ENST00000435835.3_Nonsense_Mutation_p.R143*|LRRC36_ENST00000290940.7_5'UTR	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	264										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		GTCCACAGTCCGATCCCCAGA	0.428000													21	74					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89445006	89445006	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr3:89445006G>A	ENST00000336596.2	+	6	1551	c.1326G>A	c.(1324-1326)acG>acA	p.T442T	EPHA3_ENST00000452448.2_Silent_p.T442T|EPHA3_ENST00000494014.1_Silent_p.T442T	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	442	Fibronectin type-III 2.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CTGTCCTGACGATTAAGAAAG	0.458000										TSP Lung(6;0.00050)			33	44					0	0	1	0	0
ZNF350	59348	broad.mit.edu	37	19	52469017	52469017	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:52469017C>T	ENST00000243644.4	-	5	916	c.689G>A	c.(688-690)gGa>gAa	p.G230E	HCCAT3_ENST00000600253.1_RNA|HCCAT3_ENST00000595010.1_RNA	NM_021632.3	NP_067645.3	Q9GZX5	ZN350_HUMAN	zinc finger protein 350	230					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(7)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0179)		GGGTTTCTCTCCTGTATGCAT	0.418000													23	119					0	0	1	0	0
MMP24	10893	broad.mit.edu	37	20	33834786	33834786	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr20:33834786G>A	ENST00000246186.6	+	2	475	c.390G>A	c.(388-390)acG>acA	p.T130T	MMP24-AS1_ENST00000454184.1_RNA|MMP24-AS1_ENST00000456350.1_RNA|MMP24-AS1_ENST00000438751.1_RNA|MMP24-AS1_ENST00000433764.1_RNA|MMP24-AS1_ENST00000566203.2_RNA|EDEM2_ENST00000540582.1_Intron	NM_006690.3	NP_006681.1	Q9Y5R2	MMP24_HUMAN	matrix metallopeptidase 24 (membrane-inserted)	130					proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(3)|large_intestine(1)|lung(2)|prostate(2)|skin(5)	14			BRCA - Breast invasive adenocarcinoma(18;0.00252)			ATCAGACAACGATCGAGTAAG	0.522000													16	56					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3953084	3953084	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:3953084G>A	ENST00000381638.2	-	37	6057	c.5933C>T	c.(5932-5934)cCa>cTa	p.P1978L		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	1978							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CACAGTGACTGGTAGGGCCTG	0.512000													38	39					0	0	1	0	0
SNRPD2	6633	broad.mit.edu	37	19	46191731	46191731	+	Silent	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:46191731G>C	ENST00000342669.3	-	2	540	c.96C>G	c.(94-96)ctC>ctG	p.L32L	SNRPD2_ENST00000585392.1_Intron|SNRPD2_ENST00000590212.1_Silent_p.L32L|SNRPD2_ENST00000391932.3_Silent_p.L22L|SNRPD2_ENST00000587367.1_Silent_p.L22L|SNRPD2_ENST00000588599.1_Silent_p.L22L|SNRPD2_ENST00000588301.1_Silent_p.L32L	NM_004597.5	NP_004588.1	P62316	SMD2_HUMAN	small nuclear ribonucleoprotein D2 polypeptide 16.5kDa	32					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding			breast(1)|large_intestine(1)|lung(2)	4		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00546)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.194)		CTGACTGTGTGAGCACAGAGA	0.542000													17	68					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75283755	75283755	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr14:75283755A>C	ENST00000325680.7	+	14	5931	c.5807A>C	c.(5806-5808)gAc>gCc	p.D1936A	YLPM1_ENST00000552421.1_Missense_Mutation_p.D1230A|YLPM1_ENST00000238571.3_Missense_Mutation_p.D1701A	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1741					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GCCATCAATGACAGAGTTAGG	0.408000													9	15					0	0	1	0	0
RPA3	6119	broad.mit.edu	37	7	7680043	7680043	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr7:7680043C>A	ENST00000223129.4	-	5	1178	c.7G>T	c.(7-9)Gac>Tac	p.D3Y	RPA3_ENST00000396682.2_Missense_Mutation_p.D3Y|RPA3_ENST00000406109.1_Intron	NM_002947.3	NP_002938.1	P35244	RFA3_HUMAN	replication protein A3, 14kDa	3					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	cytoplasm|DNA replication factor A complex|nucleoplasm	protein binding|single-stranded DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.202)		TCCATCATGTCCACCATGATT	0.587000								Direct reversal of damage;Nucleotide excision repair (NER)					13	45					0.000151284	0.000157968	1	1	0
GPRC5C	55890	broad.mit.edu	37	17	72436480	72436480	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:72436480C>T	ENST00000392627.1	+	2	1826	c.700C>T	c.(700-702)Cag>Tag	p.Q234*	GPRC5C_ENST00000481232.1_Intron|GPRC5C_ENST00000392629.2_Nonsense_Mutation_p.Q201*|GPRC5C_ENST00000342648.5_Intron	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	189						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						GGGCGGCCCTCAGGGCAACAG	0.612000													20	19					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53644386	53644386	+	Silent	SNP	T	T	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:53644386T>A	ENST00000452676.2	-	5	2124	c.1698A>T	c.(1696-1698)ggA>ggT	p.G566G	ZNF347_ENST00000334197.7_Silent_p.G565G|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000601469.2_Silent_p.G566G	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		AAGGTTTTTCTCCAGTATGGA	0.408000													6	242					0	0	1	0	0
TAF6	6878	broad.mit.edu	37	7	99704883	99704883	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr7:99704883G>A	ENST00000344095.4	-	15	2545	c.2020C>T	c.(2020-2022)Cag>Tag	p.Q674*	TAF6_ENST00000418432.2_Nonsense_Mutation_p.Q598*|AP4M1_ENST00000421755.1_Intron|TAF6_ENST00000472509.1_Nonsense_Mutation_p.Q731*|TAF6_ENST00000452041.1_Nonsense_Mutation_p.Q674*|TAF6_ENST00000437822.2_Nonsense_Mutation_p.Q711*|TAF6_ENST00000453269.2_Nonsense_Mutation_p.Q674*	NM_005641.3	NP_005632.1	P49848	TAF6_HUMAN	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	674					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(2)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGAGCAGGCTGAGGGGAGCCG	0.627000													7	19					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	172735776	172735776	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr4:172735776C>T	ENST00000506823.1	+	2	702	c.45C>T	c.(43-45)ttC>ttT	p.F15F	GALNTL6_ENST00000511251.1_Silent_p.F15F	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	15						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						CTTTGTTGTTCACGGTGGCTT	0.473000													21	34					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7759106	7759106	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:7759106A>C	ENST00000547372.1	+	16	1532	c.1226A>C	c.(1225-1227)cAg>cCg	p.Q409P	RBFOX1_ENST00000311745.5_Silent_p.P369P|RBFOX1_ENST00000550418.1_Silent_p.P348P|RBFOX1_ENST00000552089.1_Missense_Mutation_p.Q383P|RBFOX1_ENST00000547338.1_Silent_p.P348P|RBFOX1_ENST00000553186.1_Silent_p.P321P|RBFOX1_ENST00000436368.2_Silent_p.P369P|RBFOX1_ENST00000355637.4_Missense_Mutation_p.Q387P|RBFOX1_ENST00000422070.4_Silent_p.P391P|RBFOX1_ENST00000535565.2_Missense_Mutation_p.Q323P|RBFOX1_ENST00000340209.4_Silent_p.P353P			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	75					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						CACTTGCTCCAGCCCCCACCT	0.522000													6	68					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45285711	45285711	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:45285711C>G	ENST00000270279.3	+	4	805	c.742C>G	c.(742-744)Caa>Gaa	p.Q248E	CBLC_ENST00000341505.4_Missense_Mutation_p.Q248E	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	248	Cbl-PTB.|SH2-like.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				TGATGAGGTCCAAGAGCGTCT	0.627000			M		AML								21	39					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103899698	103899698	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr10:103899698G>T	ENST00000278070.2	+	5	1472	c.1433G>T	c.(1432-1434)aGg>aTg	p.R478M	PPRC1_ENST00000413464.2_Missense_Mutation_p.R478M	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TATGCCAGGAGGCTGAGGTCA	0.542000													3	34					1	1	1	1	0
ZMAT2	153527	broad.mit.edu	37	5	140085332	140085332	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:140085332G>T	ENST00000274712.3	+	6	718	c.591G>T	c.(589-591)aaG>aaT	p.K197N		NM_144723.1	NP_653324.1	Q96NC0	ZMAT2_HUMAN	zinc finger, matrin-type 2	197						nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(1)|liver(1)|lung(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACCAAGAAGAGTTACTGAG	0.493000													18	56					4.96729e-08	5.42645e-08	1	1	0
ZNF182	7569	broad.mit.edu	37	X	47842712	47842712	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:47842712C>T	ENST00000396965.1	-	5	522	c.172G>A	c.(172-174)Gag>Aag	p.E58K	ZNF182_ENST00000305127.6_Missense_Mutation_p.E58K|ZNF182_ENST00000376943.3_Missense_Mutation_p.E39K	NM_001178099.1	NP_001171570.1	P17025	ZN182_HUMAN	zinc finger protein 182	58	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)	22						CTGTAGGTCTCCAGCATCACG	0.468000													29	58					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947202	237947202	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:237947202G>A	ENST00000366574.2	+	90	12507	c.12190G>A	c.(12190-12192)Gaa>Aaa	p.E4064K	RYR2_ENST00000360064.6_Missense_Mutation_p.E4070K|RYR2_ENST00000542537.1_Missense_Mutation_p.E4048K|RYR2_ENST00000609119.1_3'UTR	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4064					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTCAGAAACGGAATTTCTTTT	0.478000													7	15					0	0	1	0	0
SBSN	374897	broad.mit.edu	37	19	36018914	36018914	+	Silent	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:36018914G>C	ENST00000452271.2	-	1	298	c.270C>G	c.(268-270)ctC>ctG	p.L90L	SBSN_ENST00000518157.1_Silent_p.L90L	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	90	Ala/Gly/His-rich.					extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TGCCGTGGTTGAGCCCCTGGA	0.552000													38	71					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37365500	37365500	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr3:37365500C>G	ENST00000361924.2	+	14	2497	c.2123C>G	c.(2122-2124)tCt>tGt	p.S708C	GOLGA4_ENST00000356847.4_Missense_Mutation_p.S730C|GOLGA4_ENST00000444882.1_Intron	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	708	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						GAGGAACTTTCTGTTCTGAAA	0.358000													24	25					0	0	1	0	0
MOGAT1	116255	broad.mit.edu	37	2	223554168	223554168	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:223554168G>A	ENST00000446656.3	+	3	458	c.458G>A	c.(457-459)cGa>cAa	p.R153Q		NM_058165.2	NP_477513.2	Q96PD6	MOGT1_HUMAN	monoacylglycerol O-acyltransferase 1	153					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			breast(1)|cervix(1)|endometrium(1)|lung(5)|urinary_tract(1)	9		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)		CCTGTCTTTCGAGAATATGTG	0.463000													20	42					0	0	1	0	0
DUSP11	8446	broad.mit.edu	37	2	73994324	73994324	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:73994324C>T	ENST00000272444.3	-	6	687	c.646G>A	c.(646-648)Gat>Aat	p.D216N	DUSP11_ENST00000480948.1_5'UTR	NM_003584.2	NP_003575.2	O75319	DUS11_HUMAN	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	169					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|skin(1)	12						CCTTCTACATCAATCAAATAT	0.299000													11	97					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45507591	45507591	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr21:45507591G>A	ENST00000291574.4	+	17	2726	c.2551G>A	c.(2551-2553)Gag>Aag	p.E851K		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	851					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						ACAGTCTTCTGAGGCCGCGCT	0.527000													17	31					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042310	75042310	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr15:75042310G>T	ENST00000343932.4	+	2	294	c.231G>T	c.(229-231)caG>caT	p.Q77H		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	77					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	ACGTCCTGCAGATCCGCATTG	0.682000													12	30					0.0809354	0.0815628	1	1	0
NEMF	9147	broad.mit.edu	37	14	50267267	50267267	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr14:50267267G>C	ENST00000298310.5	-	23	2692	c.2243C>G	c.(2242-2244)tCt>tGt	p.S748C	NEMF_ENST00000546046.1_Missense_Mutation_p.S727C|NEMF_ENST00000545773.1_Missense_Mutation_p.S706C|NEMF_ENST00000556925.1_5'UTR			O60524	NEMF_HUMAN	nuclear export mediator factor	748						cytoplasm|nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(13)|liver(1)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	36						TTCGTCTTCAGAGCTTTCTTC	0.418000													31	85					0	0	1	0	0
NOL8	55035	broad.mit.edu	37	9	95085758	95085758	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:95085758A>G	ENST00000545558.1	-	3	659	c.167T>C	c.(166-168)aTc>aCc	p.I56T	NOL8_ENST00000542053.1_5'UTR|NOL8_ENST00000358855.4_5'UTR|NOL8_ENST00000543985.1_5'UTR|NOL8_ENST00000442668.2_Missense_Mutation_p.I56T|NOL8_ENST00000535387.1_Missense_Mutation_p.I56T			Q76FK4	NOL8_HUMAN	nucleolar protein 8	56	RRM.				DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						ACTGATGTTGATATATGCAAA	0.308000													8	19					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87898678	87898678	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr10:87898678G>A	ENST00000327946.7	-	4	709	c.624C>T	c.(622-624)ctC>ctT	p.L208L		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	208						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TCGTGGTGAAGAGGCTGGTGA	0.577000										Multiple Myeloma(13;0.14)			44	112					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101565153	101565153	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr10:101565153G>C	ENST00000370449.4	+	11	1592	c.1479G>C	c.(1477-1479)aaG>aaC	p.K493N		NM_000392.3	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	493	ABC transmembrane type-1 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	AAAATATGAAGAATAAAGACA	0.423000													11	51					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76481699	76481699	+	Silent	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:76481699C>G	ENST00000389840.5	-	47	7498	c.7374G>C	c.(7372-7374)ctG>ctC	p.L2458L	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Silent_p.L2467L|RP11-559N14.5_ENST00000588565.1_RNA|RP11-559N14.5_ENST00000585969.1_RNA					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGTCCGTGTTCAGGCTTTCCA	0.627000													7	25					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106208723	106208723	+	RNA	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr14:106208723C>G	ENST00000390548.2	-	0	295																											GATTTGGGCTCTGCAGAGAGA	0.587000													59	121					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37665633	37665633	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr21:37665633G>C	ENST00000399151.3	+	37	6746	c.6661G>C	c.(6661-6663)Gat>Cat	p.D2221H		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	2221					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CAGTAGCTCTGATGAGATCAC	0.448000													29	47					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109459059	109459059	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr13:109459059G>C	ENST00000356711.2	+	7	834	c.708G>C	c.(706-708)gaG>gaC	p.E236D	MYO16_ENST00000357550.2_Missense_Mutation_p.E236D|MYO16_ENST00000251041.5_Missense_Mutation_p.E236D	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	236					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GCTACAAGGAGGTGGTGTCTC	0.458000													5	78					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58571038	58571038	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:58571038G>C	ENST00000317147.5	-	39	5833	c.5501C>G	c.(5500-5502)tCt>tGt	p.S1834C	CNOT1_ENST00000569240.1_Missense_Mutation_p.S1829C|CNOT1_ENST00000245138.4_Missense_Mutation_p.S685C	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1834					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AGAGATCCCAGAATGCATCAT	0.478000													38	70					0	0	1	0	0
PRTN3	5657	broad.mit.edu	37	19	847847	847847	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:847847G>C	ENST00000544537.2	+	4	708	c.526G>C	c.(526-528)Gac>Cac	p.D176H	PRTN3_ENST00000234347.5_Missense_Mutation_p.D217H			P24158	PRTN3_HUMAN	proteinase 3	217	Peptidase S1.				collagen catabolic process|positive regulation of cell proliferation|proteolysis		protein binding|serine-type endopeptidase activity			lung(1)|ovary(2)|urinary_tract(1)	4		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAAGGAATAGACTCCTTCGT	0.612000													4	7					0	0	1	0	0
SLC26A4	5172	broad.mit.edu	37	7	107314747	107314747	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr7:107314747G>T	ENST00000265715.3	+	5	778	c.554G>T	c.(553-555)aGa>aTa	p.R185I		NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	185			R -> T (found at heterozygosity in a patient with non-syndromic deafness; uncertain pathological significance).		regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						GATACAGCTAGAGTCCTGATT	0.398000									Pendred syndrome				8	55					0.000442599	0.000458469	1	1	0
TBC1D8B	54885	broad.mit.edu	37	X	106093528	106093528	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:106093528C>T	ENST00000357242.5	+	12	2285	c.2111C>T	c.(2110-2112)aCa>aTa	p.T704I	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.T698I	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	704						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GAAGCTGTGACAGCCTTAAAC	0.378000													10	71					0	0	1	0	0
PNISR	25957	broad.mit.edu	37	6	99849333	99849333	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr6:99849333C>G	ENST00000369239.5	-	12	1705	c.1501G>C	c.(1501-1503)Gaa>Caa	p.E501Q	PNISR_ENST00000438806.1_Missense_Mutation_p.E501Q	NM_032870.2	NP_116259.2	Q8TF01	PNISR_HUMAN	PNN-interacting serine/arginine-rich protein	501						nuclear speck				breast(2)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24						TTTTCTTTTTCTTTATGCTCT	0.388000													34	39					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	31350878	31350878	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:31350878C>G	ENST00000225823.2	-	6	2222		c.e6+1		ASIC2_ENST00000359872.6_Splice_Site	NM_183377.1	NP_899233.1	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2						central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	ACTAAACTTACGAGATATATT	0.438000													28	43					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55147170	55147170	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr6:55147170C>G	ENST00000370862.3	+	7	1589	c.1253C>G	c.(1252-1254)tCa>tGa	p.S418*		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	418					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GATAACATATCAAAACTTTCT	0.473000													3	32					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73565329	73565329	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:73565329G>A	ENST00000392550.3	+	14	1621	c.1504G>A	c.(1504-1506)Gac>Aac	p.D502N	LLGL2_ENST00000577200.1_Missense_Mutation_p.D502N|LLGL2_ENST00000167462.5_Missense_Mutation_p.D502N	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	502					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding	p.D502N(1)		NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CTACAGTGATGACCCCCGGCT	0.672000													22	34					0	0	1	0	0
CATSPER3	347732	broad.mit.edu	37	5	134346110	134346110	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:134346110G>A	ENST00000282611.6	+	7	1070	c.984G>A	c.(982-984)aaG>aaA	p.K328K		NM_178019.2	NP_821138.1	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	328					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGAACTTTAAGAAGACCTTGA	0.468000													11	57					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5397353	5397353	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr18:5397353C>T	ENST00000341928.2	-	18	2885	c.2545G>A	c.(2545-2547)Gag>Aag	p.E849K	EPB41L3_ENST00000542146.1_Missense_Mutation_p.E154K|EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000342933.3_Missense_Mutation_p.E849K|EPB41L3_ENST00000400111.3_Missense_Mutation_p.E627K|EPB41L3_ENST00000540638.2_Missense_Mutation_p.E627K|EPB41L3_ENST00000544123.1_Missense_Mutation_p.E680K|EPB41L3_ENST00000427684.2_Missense_Mutation_p.E146K	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	849	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						ACCACCTTCTCAGTGCTAAGC	0.592000													5	41					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													3	52					0	0	1	0	0
SVOPL	136306	broad.mit.edu	37	7	138333863	138333863	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr7:138333863G>A	ENST00000421622.1	-	4	402	c.194C>T	c.(193-195)tCc>tTc	p.S65F	SVOPL_ENST00000288513.5_Missense_Mutation_p.S33F|SVOPL_ENST00000419765.3_Missense_Mutation_p.S185F|SVOPL_ENST00000436657.1_Missense_Mutation_p.S33F			Q8N434	SVOPL_HUMAN	SVOP-like	185						integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						GATGAGCAGGGAGCCCGCAAG	0.488000													11	40					0	0	1	0	0
OGN	4969	broad.mit.edu	37	9	95165608	95165608	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:95165608G>A	ENST00000262551.4	-	2	502	c.82C>T	c.(82-84)Cgc>Tgc	p.R28C	CENPP_ENST00000375587.3_Intron|OGN_ENST00000375561.5_Missense_Mutation_p.R28C	NM_033014.2	NP_148935.1	P20774	MIME_HUMAN	osteoglycin	28						extracellular space|proteinaceous extracellular matrix	growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	13						TAGATAATGCGTGAGTCCTGC	0.378000													22	64					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73678021	73678021	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:73678021C>T	ENST00000264448.6	+	8	4475	c.4364C>T	c.(4363-4365)tCa>tTa	p.S1455L	ALMS1_ENST00000409009.1_Missense_Mutation_p.S1413L|ALMS1_ENST00000377715.1_Missense_Mutation_p.S1455L	NM_015120.4	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1455	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						TTGGAAGTTTCAGTTGCTCCT	0.478000													49	112					0	0	1	0	0
DDX24	57062	broad.mit.edu	37	14	94545986	94545986	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr14:94545986C>T	ENST00000330836.5	-	2	234	c.103G>A	c.(103-105)Gac>Aac	p.D35N	DDX24_ENST00000555054.1_Intron|DDX24_ENST00000544005.1_Intron	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	35					RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		ATATTTGGGTCAATCTTCACT	0.443000													44	187					0	0	1	0	0
RPRML	388394	broad.mit.edu	37	17	45056104	45056104	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:45056104G>A	ENST00000322329.3	-	1	510	c.270C>T	c.(268-270)aaC>aaT	p.N90N	RP11-156P1.2_ENST00000571841.1_Intron|GOSR2_ENST00000439730.2_Intron|LRRC37A17P_ENST00000570478.1_RNA	NM_203400.4	NP_981945.1	Q8N4K4	RPRML_HUMAN	reprimo-like	90						integral to membrane				lung(1)	1						TGATGAGCAGGTTGCAGCCCA	0.647000													3	13					0	0	1	0	0
TTC7B	145567	broad.mit.edu	37	14	91161866	91161866	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr14:91161866C>T	ENST00000357056.2	-	6	876	c.755G>A	c.(754-756)aGa>aAa	p.R252K	TTC7B_ENST00000328459.6_Missense_Mutation_p.R252K			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	252							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				TTGAGTCGTTCTTGTTTCAAC	0.408000													36	53					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167204	140167204	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:140167204G>A	ENST00000504120.2	+	1	1329	c.1329G>A	c.(1327-1329)gtG>gtA	p.V443V	PCDHA1_ENST00000378133.3_Silent_p.V443V|PCDHA1_ENST00000394633.3_Silent_p.V443V	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGTCCGTGGAGGTGGCCG	0.667000													14	100					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2307227	2307227	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr4:2307227G>T	ENST00000290974.2	-	8	1179	c.840C>A	c.(838-840)caC>caA	p.H280Q	ZFYVE28_ENST00000515312.1_Missense_Mutation_p.H210Q|ZFYVE28_ENST00000511071.1_Missense_Mutation_p.H250Q|RP11-478C1.7_ENST00000510632.1_RNA	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	280					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GTTCCAGCGTGTGCAGCTCCT	0.627000													10	16					1.58986e-06	1.70109e-06	1	1	0
USP45	85015	broad.mit.edu	37	6	99894186	99894186	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr6:99894186C>T	ENST00000327681.6	-	14	1994	c.1462G>A	c.(1462-1464)Gat>Aat	p.D488N	USP45_ENST00000392738.2_Missense_Mutation_p.D168N|USP45_ENST00000539675.1_Intron|USP45_ENST00000500704.2_Missense_Mutation_p.D488N|USP45_ENST00000369233.2_Missense_Mutation_p.D440N	NM_001080481.1	NP_001073950.1	Q70EL2	UBP45_HUMAN	ubiquitin specific peptidase 45	488					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(2)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	22		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)		TCACTGTCATCAGTAGGGCTT	0.423000													36	40					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44948987	44948987	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:44948987G>C	ENST00000377967.4	+	25	3589		c.e25-1		KDM6A_ENST00000536777.1_Splice_Site|KDM6A_ENST00000543216.1_Splice_Site|KDM6A_ENST00000382899.4_Splice_Site	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TCTTATTTCAGAAATAATTTG	0.323000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								23	33					0	0	1	0	0
SPATA2	9825	broad.mit.edu	37	20	48522461	48522461	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr20:48522461G>A	ENST00000422556.1	-	3	1607	c.1258C>T	c.(1258-1260)Cat>Tat	p.H420Y	SPATA2_ENST00000543716.1_Missense_Mutation_p.H283Y|SPATA2_ENST00000289431.5_Missense_Mutation_p.H420Y	NM_001135773.1	NP_001129245.1	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	420					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	20	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			AGGCTGTCATGAGTCGAGGCC	0.662000													7	20					0	0	1	0	0
VPS36	51028	broad.mit.edu	37	13	53024700	53024700	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr13:53024700G>A	ENST00000378060.4	-	1	57	c.30C>T	c.(28-30)ctC>ctT	p.L10L		NM_001282168.1|NM_001282169.1|NM_016075.2	NP_001269097.1|NP_001269098.1|NP_057159.2	Q86VN1	VPS36_HUMAN	vacuolar protein sorting 36 homolog (S. cerevisiae)	10	GLUE N-terminal.				cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|late endosome|membrane|nucleus	lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	17		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.14e-08)		TGATCTCCAGGAGGCCGCTGG	0.701000													5	19					0	0	1	0	0
RARS	5917	broad.mit.edu	37	5	167919789	167919789	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:167919789G>A	ENST00000231572.3	+	3	360	c.306G>A	c.(304-306)gtG>gtA	p.V102V	RARS_ENST00000538719.1_5'UTR	NM_002887.3	NP_002878.2	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	102					arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|stomach(1)	22	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		CTCTGCTAGTGACACCAAGTC	0.403000													22	85					0	0	1	0	0
PARK7	11315	broad.mit.edu	37	1	8025425	8025425	+	Silent	SNP	A	A	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:8025425A>G	ENST00000493678.1	+	3	199	c.132A>G	c.(130-132)gtA>gtG	p.V44V	PARK7_ENST00000377493.5_Silent_p.V44V|PARK7_ENST00000497113.1_3'UTR|PARK7_ENST00000377488.1_Silent_p.V44V|PARK7_ENST00000338639.5_Silent_p.V44V|PARK7_ENST00000377491.1_Silent_p.V44V			Q99497	PARK7_HUMAN	parkinson protein 7	44					autophagy|cell death|cellular response to hydrogen peroxide|inflammatory response|mitochondrion organization|negative regulation of cell death|negative regulation of protein binding|neuroprotection|protein stabilization|regulation of androgen receptor signaling pathway|regulation of inflammatory response|single fertilization	mitochondrion|nucleus	mRNA binding|peptidase activity|peroxidase activity|protein homodimerization activity			large_intestine(1)	1	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;1.28e-70)|GBM - Glioblastoma multiforme(8;3.05e-36)|Colorectal(212;6.83e-08)|COAD - Colon adenocarcinoma(227;7.51e-06)|Kidney(185;5.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000414)|KIRC - Kidney renal clear cell carcinoma(229;0.000967)|STAD - Stomach adenocarcinoma(132;0.00102)|READ - Rectum adenocarcinoma(331;0.0649)		AAGACCCAGTACAGTGTAGCC	0.408000													15	49					0	0	1	0	0
FBXO34	55030	broad.mit.edu	37	14	55818155	55818155	+	Silent	SNP	T	T	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr14:55818155T>C	ENST00000313833.4	+	2	1292	c.1047T>C	c.(1045-1047)gaT>gaC	p.D349D	FBXO34_ENST00000440021.1_Silent_p.D349D	NM_017943.3	NP_060413.2	Q9NWN3	FBX34_HUMAN	F-box protein 34	349										breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						TATCTGTGGATTGTGGCCCTT	0.542000													24	41					0	0	1	0	0
UTP14C	9724	broad.mit.edu	37	13	52604165	52604165	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr13:52604165G>C	ENST00000521776.2	+	2	1958	c.1225G>C	c.(1225-1227)Gaa>Caa	p.E409Q		NM_021645.5	NP_067677.4	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	409					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				breast(4)|cervix(1)|endometrium(1)|large_intestine(10)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	32		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		TGAGGCAGAAGAAAGACCAGT	0.502000													12	32					0	0	1	0	0
FAM86FP	653113	broad.mit.edu	37	12	8386955	8386955	+	RNA	SNP	T	T	C	rs75997195		TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:8386955T>C	ENST00000427893.2	-	0	811																											CTTGTGCTCCTGGCAGGCAGC	0.612000													4	68					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998290	27998290	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:27998290C>T	ENST00000441525.1	-	1	1276	c.1162G>A	c.(1162-1164)Gat>Aat	p.D388N		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	388										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						GTTGGGAAATCACAATAAACC	0.408000													19	46					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51287509	51287509	+	Silent	SNP	C	C	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr7:51287509C>A	ENST00000395542.2	-	2	358	c.174G>T	c.(172-174)ctG>ctT	p.L58L	COBL_ENST00000395540.2_Silent_p.L58L|COBL_ENST00000441453.1_Silent_p.L58L|COBL_ENST00000265136.7_Silent_p.L58L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	58										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					TGCTGGCCCTCAGCGCCTCCT	0.642000													9	36					1.12685e-05	1.19098e-05	1	1	0
MARCH7	64844	broad.mit.edu	37	2	160585519	160585519	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:160585519G>C	ENST00000259050.4	+	2	108		c.e2-1		MARCH7_ENST00000539065.1_Splice_Site|MARCH7_ENST00000473749.1_Splice_Site|MARCH7_ENST00000409175.1_Splice_Site	NM_001282805.1|NM_001282807.1|NM_022826.2	NP_001269734.1|NP_001269736.1|NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase								ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						TTATTTCACAGAAAAATCTTT	0.333000													16	19					0	0	1	0	0
PIP	5304	broad.mit.edu	37	7	142836242	142836242	+	Silent	SNP	C	C	T	rs141238396		TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr7:142836242C>T	ENST00000291009.3	+	3	316	c.276C>T	c.(274-276)gaC>gaT	p.D92D		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	92						extracellular region	actin binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		GCCTATGTGACGACAATCCAA	0.468000													20	70					0	0	1	0	0
WDR26	80232	broad.mit.edu	37	1	224619465	224619465	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:224619465G>A	ENST00000414423.2	-	2	634	c.441C>T	c.(439-441)ctC>ctT	p.L147L	WDR26_ENST00000366852.2_Silent_p.L147L|WDR26_ENST00000295024.6_5'UTR	NM_001115113.2|NM_025160.6	NP_001108585.2|NP_079436.4	Q9H7D7	WDR26_HUMAN	WD repeat domain 26	147	LisH.					cytoplasm|nucleus				biliary_tract(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)	18				GBM - Glioblastoma multiforme(131;0.0104)		ACTCTTGCATGAGGAGATCAA	0.398000													18	67					0	0	1	0	0
PAPOLG	64895	broad.mit.edu	37	2	61007912	61007912	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:61007912C>T	ENST00000238714.3	+	10	1153	c.904C>T	c.(904-906)Cgg>Tgg	p.R302W	PAPOLG_ENST00000483370.1_3'UTR	NM_022894.3	NP_075045.2	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	302					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	35	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			CTGGGATCCTCGGGTATGTGA	0.383000													15	66					0	0	1	0	0
HDAC1	3065	broad.mit.edu	37	1	32793253	32793253	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:32793253A>C	ENST00000373548.3	+	6	695	c.611A>C	c.(610-612)tAc>tCc	p.Y204S	HDAC1_ENST00000490081.1_3'UTR|HDAC1_ENST00000373541.2_Missense_Mutation_p.Y11S	NM_004964.2	NP_004955.2	Q13547	HDAC1_HUMAN	histone deacetylase 1	204	Histone deacetylase.				anti-apoptosis|blood coagulation|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of androgen receptor signaling pathway|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytosol|NuRD complex|Sin3 complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|identical protein binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18		Breast(348;0.000523)|Lung NSC(340;0.000992)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Lung SC(1967;0.113)		KIRC - Kidney renal clear cell carcinoma(1967;0.138)	Vorinostat(DB02546)	TATGGAGAGTACTTCCCAGGA	0.532000													7	46					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53420310	53420310	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr13:53420310G>A	ENST00000377942.3	-	1	2465	c.2262C>T	c.(2260-2262)atC>atT	p.I754I	PCDH8_ENST00000338862.4_Silent_p.I754I	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	754					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CGGCCAGCACGATGATGACGA	0.701000													5	42					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113461187	113461187	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr4:113461187C>T	ENST00000505019.1	-	27	6129	c.6004G>A	c.(6004-6006)Gag>Aag	p.E2002K	RP11-402J6.1_ENST00000504009.1_RNA	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	0										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		ATAATGATCTCCTTTTCAGCT	0.398000													7	10					0	0	1	0	0
ST20	400410	broad.mit.edu	37	15	80191373	80191373	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr15:80191373T>G	ENST00000478497.1	-	3	819	c.140A>C	c.(139-141)gAa>gCa	p.E47A	ST20_ENST00000562759.1_Missense_Mutation_p.E47A|ST20_ENST00000485386.1_Missense_Mutation_p.E47A|ST20-MTHFS_ENST00000479961.1_Intron|ST20-MTHFS_ENST00000494999.1_Intron	NM_001100879.1	NP_001094349.1			suppressor of tumorigenicity 20											kidney(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4						CAGTATTGCTTCAGGACAGAA	0.388000													4	82					0	0	1	0	0
SLC1A4	6509	broad.mit.edu	37	2	65245211	65245211	+	Silent	SNP	G	G	A	rs115498588	byFrequency	TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:65245211G>A	ENST00000234256.3	+	6	1284	c.1041G>A	c.(1039-1041)gcG>gcA	p.A347A	SLC1A4_ENST00000531327.1_Silent_p.A49A	NM_003038.4	NP_003029.2	P43007	SATT_HUMAN	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	347					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|urinary_tract(1)	13					L-Alanine(DB00160)	CTAGCTCAGCGACCCTTCCCT	0.502000													8	58					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44876219	44876219	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr15:44876219C>G	ENST00000261866.7	-	30	5675	c.5659G>C	c.(5659-5661)Gat>Cat	p.D1887H	SPG11_ENST00000535302.2_Missense_Mutation_p.D1887H|SPG11_ENST00000427534.2_Missense_Mutation_p.D1887H|SPG11_ENST00000558319.1_Missense_Mutation_p.D1887H	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	1887					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CAGCCATCATCCAGTAGGCGC	0.443000													41	86					0	0	1	0	0
DDX3X	1654	broad.mit.edu	37	X	41204495	41204495	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:41204495G>A	ENST00000399959.2	+	11	1943	c.1088G>A	c.(1087-1089)aGa>aAa	p.R363K	DDX3X_ENST00000441189.2_Intron|DDX3X_ENST00000542215.1_3'UTR|DDX3X_ENST00000457138.2_Missense_Mutation_p.R347K|DDX3X_ENST00000478993.1_3'UTR	NM_001193416.1|NM_001193417.1|NM_001356.3	NP_001180345.1|NP_001180346.1|NP_001347.3	O00571	DDX3X_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	363	Helicase ATP-binding.|Necessary for interaction with XPO1.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			NS(3)|breast(8)|central_nervous_system(36)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84						CAGATTCGTAGAATAGTCGAA	0.408000										HNSCC(61;0.18)			17	132					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14768468	14768468	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr3:14768468G>A	ENST00000253697.3	+	11	2079	c.1627G>A	c.(1627-1629)Gag>Aag	p.E543K	C3orf20_ENST00000435614.1_Missense_Mutation_p.E421K|C3orf20_ENST00000412910.1_Missense_Mutation_p.E421K	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	543						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						AGCCCTGGCTGAGATCAAGAA	0.542000													17	21					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042595	75042595	+	Silent	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr15:75042595G>C	ENST00000343932.4	+	2	579	c.516G>C	c.(514-516)ctG>ctC	p.L172L		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	172					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CTAAGGCCCTGATCAGCAGGT	0.587000													30	61					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52962747	52962747	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:52962747C>T	ENST00000371544.3	-	5	1370	c.1108G>A	c.(1108-1110)Gat>Aat	p.D370N	ZCCHC11_ENST00000371541.1_5'UTR|ZCCHC11_ENST00000257177.4_Missense_Mutation_p.D370N	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	370					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						AGGTCATCATCTGTTATTCCA	0.398000													8	46					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37618547	37618547	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:37618547G>T	ENST00000447079.4	+	1	256	c.223G>T	c.(223-225)Gat>Tat	p.D75Y	CDK12_ENST00000430627.2_Missense_Mutation_p.D75Y	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	75					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						GGAGTATGATGATATCAGCTC	0.532000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			3	51					0.115264	0.115709	1	1	0
VAT1	10493	broad.mit.edu	37	17	41168126	41168126	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr17:41168126C>G	ENST00000355653.3	-	6	1229	c.1134G>C	c.(1132-1134)aaG>aaC	p.K378N	VAT1_ENST00000587173.1_Missense_Mutation_p.K310N|VAT1_ENST00000420567.3_Missense_Mutation_p.K244N	NM_006373.3	NP_006364.2	Q99536	VAT1_HUMAN	vesicle amine transport 1	378						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	9		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		TGCCCACATTCTTCTTCTCCT	0.557000													102	148					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228491470	228491470	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:228491470C>T	ENST00000570156.2	+	52	13907	c.13833C>T	c.(13831-13833)ccC>ccT	p.P4611P	OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000366707.4_Silent_p.P1301P|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000359599.6_3'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3654	Fibronectin type-III 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGCGGCCCCCGTGGAGTGGC	0.612000													28	79					0	0	1	0	0
PLS3	5358	broad.mit.edu	37	X	114877631	114877631	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:114877631G>C	ENST00000420625.2	+	10	1128	c.994G>C	c.(994-996)Gat>Cat	p.D332H	PLS3_ENST00000289290.3_Missense_Mutation_p.D296H|PLS3_ENST00000537301.1_Missense_Mutation_p.D319H|PLS3_ENST00000355899.3_Missense_Mutation_p.D332H|PLS3_ENST00000539310.1_Missense_Mutation_p.D287H|PLS3_ENST00000543070.1_Intron	NM_001136025.3|NM_001172335.1|NM_001282338.1	NP_001129497.1|NP_001165806.1|NP_001269267.1	P13797	PLST_HUMAN	plastin 3	332	Actin-binding 1.|CH 2.					cytoplasm	actin binding|calcium ion binding			NS(2)|breast(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)	26						ACAGGAAACAGATGATTTGAA	0.393000													18	70					0	0	1	0	0
ZMAT2	153527	broad.mit.edu	37	5	140085340	140085340	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr5:140085340G>A	ENST00000274712.3	+	6	726	c.599G>A	c.(598-600)tGa>tAa	p.*200*		NM_144723.1	NP_653324.1	Q96NC0	ZMAT2_HUMAN	zinc finger, matrin-type 2	0						nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(1)|liver(1)|lung(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAGTTACTGAGGCTTTCTG	0.493000													17	52					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154055956	154055956	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr3:154055956G>T	ENST00000389740.2	-	4	1827	c.1728C>A	c.(1726-1728)agC>agA	p.S576R		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	576						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GCCCTTCTGCGCTTACCTCAT	0.463000													51	138					1.86277e-20	2.09662e-20	1	1	0
VPS13D	55187	broad.mit.edu	37	1	12557613	12557613	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:12557613C>A	ENST00000358136.3	+	68	12852	c.12722C>A	c.(12721-12723)cCc>cAc	p.P4241H	VPS13D_ENST00000356315.4_Missense_Mutation_p.P4216H|VPS13D_ENST00000543710.1_Missense_Mutation_p.P45H|VPS13D_ENST00000496628.1_3'UTR|VPS13D_ENST00000471923.1_5'UTR|VPS13D_ENST00000543766.1_Missense_Mutation_p.P239H	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	4240					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GGGCTGCTTCCCCGATATTCT	0.532000													3	45					0.014758	0.0149886	1	1	0
ZNF583	147949	broad.mit.edu	37	19	56935499	56935499	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:56935499C>T	ENST00000333201.9	+	5	1682	c.1472C>T	c.(1471-1473)cCt>cTt	p.P491L	ZNF583_ENST00000291598.7_Missense_Mutation_p.P491L|ZNF583_ENST00000585612.1_Intron	NM_001159861.1|NM_152478.2	NP_001153333.1|NP_689691.2	Q96ND8	ZN583_HUMAN	zinc finger protein 583	491					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		GGAGAGAAACCTTATGAATGT	0.373000													17	67					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49176771	49176771	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:49176771C>G	ENST00000307885.4	-	1	1141	c.447G>C	c.(445-447)caG>caC	p.Q149H	ADCY6_ENST00000550422.1_Missense_Mutation_p.Q149H|ADCY6_ENST00000357869.3_Missense_Mutation_p.Q149H	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	149					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						TCAGGCTGCTCTGGTTCATCT	0.647000													12	24					0	0	1	0	0
RPRM	56475	broad.mit.edu	37	2	154334957	154334957	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:154334957G>T	ENST00000325926.3	-	1	365	c.123C>A	c.(121-123)ttC>ttA	p.F41L	AC012501.2_ENST00000424322.1_RNA	NM_019845.2	NP_062819.1	Q9NS64	RPRM_HUMAN	reprimo, TP53 dependent G2 arrest mediator candidate	41					cell cycle arrest	cytoplasm|integral to membrane	protein binding			large_intestine(2)|lung(1)|prostate(1)	4						CTCCCTCCGCGAAGCCGTCGT	0.667000													6	19					3.59834e-05	3.78772e-05	1	1	0
KIF27	55582	broad.mit.edu	37	9	86457210	86457210	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:86457210C>T	ENST00000297814.2	-	17	3806	c.3663G>A	c.(3661-3663)aaG>aaA	p.K1221K	KIF27_ENST00000334204.2_Silent_p.K1124K|KIF27_ENST00000413982.1_Silent_p.K1155K|RP11-575L7.4_ENST00000591217.1_RNA	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	1221					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TAAGTTTCTTCTTATGATCCC	0.383000													32	33					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7174624	7174624	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:7174624C>T	ENST00000341500.5	-	4	1132	c.1093G>A	c.(1093-1095)Ggg>Agg	p.G365R	INSR_ENST00000302850.5_Missense_Mutation_p.G365R	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	365					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATCAGACTCCCGTTGATGACG	0.612000													8	44					0	0	1	0	0
CAMK2G	818	broad.mit.edu	37	10	75609037	75609037	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr10:75609037G>A	ENST00000423381.1	-	6	519	c.396C>T	c.(394-396)atC>atT	p.I132I	CAMK2G_ENST00000322635.3_Silent_p.I132I|CAMK2G_ENST00000305762.7_Silent_p.I132I|CAMK2G_ENST00000322680.3_Silent_p.I132I|CAMK2G_ENST00000351293.3_Silent_p.I132I|CAMK2G_ENST00000394762.2_Silent_p.I132I|CAMK2G_ENST00000372765.1_Silent_p.I132I|CAMK2G_ENST00000444854.2_Intron|CAMK2G_ENST00000472912.1_5'UTR	NM_001204492.1	NP_001191421.1	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II gamma	132	Protein kinase.				insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity	p.I132I(2)		kidney(2)|large_intestine(2)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	15	Prostate(51;0.0112)					CCCTGTGGACGATGTCATGCT	0.522000											OREG0020267	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	13					0	0	1	0	0
ACCSL	390110	broad.mit.edu	37	11	44071666	44071666	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr11:44071666G>A	ENST00000378832.1	+	2	615	c.559G>A	c.(559-561)Gaa>Aaa	p.E187K		NM_001031854.2	NP_001027025.2	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like	187							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(14)|ovary(5)|pancreas(1)|skin(2)	34						TCTGATGACTGAAAGAGTAAG	0.512000													13	61					0	0	1	0	0
UTP14C	9724	broad.mit.edu	37	13	52604156	52604156	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr13:52604156G>T	ENST00000521776.2	+	2	1949	c.1216G>T	c.(1216-1218)Gag>Tag	p.E406*		NM_021645.5	NP_067677.4	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	406					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				breast(4)|cervix(1)|endometrium(1)|large_intestine(10)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	32		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		TTCTGCAAGTGAGGCAGAAGA	0.493000													12	35					1.08611e-07	1.18154e-07	1	1	0
ZEB2	9839	broad.mit.edu	37	2	145147383	145147383	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:145147383C>T	ENST00000558170.2	-	10	4464	c.3280G>A	c.(3280-3282)Gag>Aag	p.E1094K	ZEB2_ENST00000409487.3_Missense_Mutation_p.E1094K|ZEB2_ENST00000539609.3_Missense_Mutation_p.E1070K|ZEB2_ENST00000303660.4_Missense_Mutation_p.E1094K	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	1094	Glu-rich (acidic).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding	p.E1094K(1)		breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCGCGCGCCTCGCGCTCCGCC	0.617000													4	59					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183211937	183211937	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr3:183211937C>G	ENST00000341319.3	-	5	1315	c.1280G>C	c.(1279-1281)gGa>gCa	p.G427A		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	427										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GTCAAAGCCTCCGATCACATA	0.458000													31	64					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202698960	202698960	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:202698960C>A	ENST00000367265.3	-	26	5536	c.4372G>T	c.(4372-4374)Gaa>Taa	p.E1458*	KDM5B_ENST00000367264.2_Nonsense_Mutation_p.E1494*	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1458					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						CGAACTAATTCATAGCTACGC	0.463000													69	182					7.33394e-39	8.29054e-39	1	1	0
CDR1	1038	broad.mit.edu	37	X	139865950	139865950	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:139865950C>T	ENST00000370532.2	-	1	773	c.582G>A	c.(580-582)tgG>tgA	p.W194*		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	194	5 X 6 AA approximate repeats.									breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				TCCTGAAGATCCACGTCTTCC	0.438000													42	100					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187519392	187519392	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:187519392C>G	ENST00000261023.3	+	16	1795	c.1521C>G	c.(1519-1521)ttC>ttG	p.F507L	AC017101.10_ENST00000453665.1_RNA|ITGAV_ENST00000433736.2_Missense_Mutation_p.F461L|ITGAV_ENST00000374907.3_Missense_Mutation_p.F471L	NM_002210.3	NP_002201	P06756	ITAV_HUMAN	integrin, alpha V	507					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		ATGTTAGGTTCTGCTTAAAGG	0.294000													18	36					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530562	80530562	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:80530562A>C	ENST00000295057.3	-	2	1039	c.383T>G	c.(382-384)cTg>cGg	p.L128R	CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000540488.1_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.L128R|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000541047.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	128						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						GGTGTTGGGCAGTTGGGTGAT	0.607000										HNSCC(69;0.2)			22	53					0	0	1	0	0
ZNF581	51545	broad.mit.edu	37	19	56156236	56156236	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr19:56156236C>G	ENST00000587252.1	+	2	572	c.299C>G	c.(298-300)tCc>tGc	p.S100C	ZNF581_ENST00000588537.1_Missense_Mutation_p.S100C|ZNF581_ENST00000270451.5_Missense_Mutation_p.S100C			Q9P0T4	ZN581_HUMAN	zinc finger protein 581	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		GAGTACATGTCCTACCTTCAG	0.602000													5	41					0	0	1	0	0
TAB3	257397	broad.mit.edu	37	X	30872938	30872938	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chrX:30872938G>T	ENST00000378933.1	-	3	1021	c.844C>A	c.(844-846)Ccc>Acc	p.P282T	TAB3_ENST00000378932.2_Missense_Mutation_p.P282T|TAB3_ENST00000288422.2_Missense_Mutation_p.P282T|TAB3_ENST00000378930.3_Missense_Mutation_p.P282T	NM_152787.3	NP_690000.2	Q8N5C8	TAB3_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 3	282	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|skin(1)	27						TGCTGTTTGGGAGAATACTGA	0.527000													7	27					0.00307968	0.00316489	1	1	0
APOB	338	broad.mit.edu	37	2	21233296	21233296	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:21233296C>A	ENST00000233242.1	-	26	6571	c.6444G>T	c.(6442-6444)aaG>aaT	p.K2148N		NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	2148	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TAATTCTATACTTTTTTGTGA	0.333000													7	99					0.00198382	0.0020468	1	1	0
FHL2	2274	broad.mit.edu	37	2	105990124	105990124	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:105990124G>T	ENST00000409177.1	-	3	692	c.571C>A	c.(571-573)Ctg>Atg	p.L191M	FHL2_ENST00000344213.4_Missense_Mutation_p.L185M|AC012360.6_ENST00000457290.2_RNA|FHL2_ENST00000322142.8_Missense_Mutation_p.L75M|FHL2_ENST00000336660.5_Intron|FHL2_ENST00000408995.1_Missense_Mutation_p.L75M|FHL2_ENST00000393352.3_Missense_Mutation_p.L75M|FHL2_ENST00000409807.1_Missense_Mutation_p.L75M|FHL2_ENST00000358129.4_Missense_Mutation_p.L75M|FHL2_ENST00000393353.3_Missense_Mutation_p.L75M			Q14192	FHL2_HUMAN	four and a half LIM domains 2	75	LIM zinc-binding 3.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent	actin cytoskeleton|focal adhesion|nucleus	androgen receptor binding|identical protein binding|transcription coactivator activity|zinc ion binding	p.L75L(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	9						TTGTCCACCAGTGAGTTTCTG	0.542000													13	24					2.27111e-07	2.46037e-07	1	1	0
CCDC23	374969	broad.mit.edu	37	1	43273169	43273169	+	Silent	SNP	G	G	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:43273169G>T	ENST00000372521.4	-	3	215	c.117C>A	c.(115-117)atC>atA	p.I39I	CCDC23_ENST00000537227.1_Silent_p.I39I|CCDC23_ENST00000372522.1_Silent_p.I39I	NM_199342.3	NP_955374.1	Q8N300	CCD23_HUMAN	coiled-coil domain containing 23	39										large_intestine(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGAGGGCATAGATCTGAATGA	0.453000													9	49					1.76689e-08	1.93836e-08	1	1	0
DCUN1D3	123879	broad.mit.edu	37	16	20871598	20871598	+	Silent	SNP	T	T	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:20871598T>C	ENST00000324344.4	-	3	810	c.525A>G	c.(523-525)caA>caG	p.Q175Q	ERI2_ENST00000564349.1_Intron|DCUN1D3_ENST00000563934.1_Silent_p.Q175Q	NM_173475.2	NP_775746.1	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 3		DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				NS(2)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)	14				GBM - Glioblastoma multiforme(48;0.249)		ATTTATCCTCTTGTTTGGCTT	0.478000													9	100					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83334220	83334220	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr15:83334220G>A	ENST00000261722.3	-	16	2167	c.1960C>T	c.(1960-1962)Cgc>Tgc	p.R654C	AP3B2_ENST00000535359.1_Missense_Mutation_p.R654C|AP3B2_ENST00000535348.1_Missense_Mutation_p.R622C|RP11-752G15.3_ENST00000560650.1_RNA	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	654	Glu/Ser-rich.				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			TCCACGTTGCGCACAGATGGG	0.602000													13	42					0	0	1	0	0
LRPPRC	10128	broad.mit.edu	37	2	44207058	44207058	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:44207058G>C	ENST00000260665.7	-	3	433	c.376C>G	c.(376-378)Cta>Gta	p.L126V	LRPPRC_ENST00000409946.1_Missense_Mutation_p.L126V|LRPPRC_ENST00000409659.1_Missense_Mutation_p.L126V	NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	126					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CTACGTAGTAGAAGCAAGGCA	0.368000													16	30					0	0	1	0	0
UTP14C	9724	broad.mit.edu	37	13	52603988	52603988	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr13:52603988G>A	ENST00000521776.2	+	2	1781	c.1048G>A	c.(1048-1050)Gaa>Aaa	p.E350K		NM_021645.5	NP_067677.4	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	350					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				breast(4)|cervix(1)|endometrium(1)|large_intestine(10)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	32		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		GGGAGGCACAGAAGTGGAAGA	0.527000													18	47					0	0	1	0	0
UBA3	9039	broad.mit.edu	37	3	69117079	69117079	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr3:69117079G>A	ENST00000361055.4	-	6	482	c.428C>T	c.(427-429)cCa>cTa	p.P143L	UBA3_ENST00000349511.4_Splice_Site_p.P129L|UBA3_ENST00000415609.2_Splice_Site_p.P102L|UBA3_ENST00000540295.1_Intron	NM_003968.3	NP_003959.3	Q8TBC4	UBA3_HUMAN	ubiquitin-like modifier activating enzyme 3	143					protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		AAAAGGATACGGAACTACATT	0.299000													20	39					0	0	1	0	0
HSPB11	51668	broad.mit.edu	37	1	54387340	54387340	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr1:54387340G>A	ENST00000194214.5	-	6	808	c.419C>T	c.(418-420)tCa>tTa	p.S140L	HSPB11_ENST00000371378.2_Intron|HSPB11_ENST00000489675.1_5'UTR	NM_016126.2	NP_057210.2	Q9Y547	HSB11_HUMAN	heat shock protein family B (small), member 11	140					cell adhesion|response to stress					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	9						GGAAAGATTTGAGACTACTGT	0.333000													18	61					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215301365	215301365	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:215301365G>C	ENST00000312504.5	+	3	1205	c.403G>C	c.(403-405)Gaa>Caa	p.E135Q	VWC2L_ENST00000427124.1_Intron|AC107218.3_ENST00000412896.1_RNA|AC107218.3_ENST00000437883.1_RNA	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	135	VWFC 2.					extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						CTCTCCATGTGAATGGTGTCG	0.443000													20	35					0	0	1	0	0
CENPO	79172	broad.mit.edu	37	2	25039532	25039532	+	Silent	SNP	C	C	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr2:25039532C>T	ENST00000380834.2	+	6	1037	c.612C>T	c.(610-612)ctC>ctT	p.L204L	CENPO_ENST00000260662.1_Silent_p.L204L|CENPO_ENST00000473706.1_Silent_p.L198L|CENPO_ENST00000395845.2_Intron			Q9BU64	CENPO_HUMAN	centromere protein O	204					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding	p.L204L(1)		breast(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					TTGCAGCCCTCCTGACTGGGC	0.493000													81	373					0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31236983	31236983	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr12:31236983G>A	ENST00000251758.5	+	3	632	c.381G>A	c.(379-381)gtG>gtA	p.V127V	DDX11_ENST00000545668.1_Silent_p.V127V|DDX11_ENST00000350437.4_Silent_p.V127V|DDX11_ENST00000542838.1_Silent_p.V127V|DDX11_ENST00000407793.2_Silent_p.V127V|DDX11_ENST00000228264.6_Silent_p.V101V			Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	127	Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GGGACCTGGTGGACCGACTAA	0.582000										Multiple Myeloma(12;0.14)			10	51					0	0	1	0	0
SMCO1	255798	broad.mit.edu	37	3	196234835	196234835	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr3:196234835C>G	ENST00000397537.2	-	3	724	c.568G>C	c.(568-570)Gag>Cag	p.E190Q		NM_001077657.1	NP_001071125.1			single-pass membrane protein with coiled-coil domains 1																		TTCCCCTTCTCAATTACCTGC	0.463000													16	19					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6662560	6662560	+	Silent	SNP	G	G	A			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr11:6662560G>A	ENST00000299441.3	-	2	696	c.285C>T	c.(283-285)gaC>gaT	p.D95D		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	95	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACTGTGTTCGTCAATGGCCA	0.632000													10	15					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21974695	21974696	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr9:21974695_21974696insT	ENST00000304494.5	-	1	401_402	c.131_132insA	c.(130-132)tacfs	p.Y44fs	CDKN2A_ENST00000498628.2_Intron|CDKN2A_ENST00000361570.3_Intron|CDKN2A_ENST00000530628.2_Intron|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000579122.1_Frame_Shift_Ins_p.Y44fs|CDKN2A_ENST00000579755.1_Intron|CDKN2A_ENST00000446177.1_Frame_Shift_Ins_p.Y44fs|CDKN2A_ENST00000498124.1_Frame_Shift_Ins_p.Y44fs|CDKN2A_ENST00000494262.1_Intron	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	44					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(25)|p.Y44*(3)|p.0(1)|p.V28_V51del(1)|p.Y44fs*76(1)|p.G45del(1)|p.Y44S(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCCTCCGACCGTAACTATTCGG	0.683		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			67	53	---	---	---	---					
LINC00423	100874167	broad.mit.edu	37	13	33469553	33469555	+	RNA	DEL	TCC	TCC	-			TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr13:33469553_33469555delTCC	ENST00000421002.1	-	0	836					NR_047020.1																						tccttctccttcctcctcctcct	0.438													3	3	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													5	8	---	---	---	---					
IL9RP3	729486	broad.mit.edu	37	16	84036	84053	+	RNA	DEL	GGGAGCCTGGAAGCACAC	GGGAGCCTGGAAGCACAC	-	rs3743872	by1000genomes	TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:84036_84053delGGGAGCCTGGAAGCACAC	ENST00000568710.1	-	0	349																											CTTGTCTCTGGGGAGCCTGGAAGCACACGGGCTGGCTA	0.633													4	3	---	---	---	---					
PDXDC2P	283970	broad.mit.edu	37	16	70013047	70013048	+	RNA	DEL	CT	CT	-	rs34135349		TCGA-ZF-A9RD-01A-11D-A42E-08	TCGA-ZF-A9RD-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a88ba1a4-5f1a-4d81-a17b-ce66fb86bc72	edc42619-b9ec-4296-bf85-d451b796ede5	g.chr16:70013047_70013048delCT	ENST00000531894.1	-	0	2519				RP11-419C5.2_ENST00000525562.1_RNA	NR_003610.1																						GTTTTGTGAACTCTCTCTCTCT	0.396													2	4	---	---	---	---					
