Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CRYBG3	131544	broad.mit.edu	37	3	97598917	97598917	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr3:97598917G>T	ENST00000182096.4	+	3	1197	c.1133G>T	c.(1132-1134)gGa>gTa	p.G378V		NM_153605.3	NP_705833.3			beta-gamma crystallin domain containing 3											breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(10)|stomach(1)|upper_aerodigestive_tract(2)	32						TTTCCAAATGGAGTTCTAATA	0.308000													4	133					0.00024832	0.000257871	1	1	0
GRM1	2911	broad.mit.edu	37	6	146625874	146625874	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr6:146625874G>C	ENST00000392299.2	+	4	1548	c.1078G>C	c.(1078-1080)Gac>Cac	p.D360H	GRM1_ENST00000492807.2_Missense_Mutation_p.D360H|GRM1_ENST00000355289.4_Missense_Mutation_p.D360H|GRM1_ENST00000282753.1_Missense_Mutation_p.D360H|GRM1_ENST00000507907.1_Missense_Mutation_p.D360H|GRM1_ENST00000361719.2_Missense_Mutation_p.D360H			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	360					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ACTGAGGCTGGACACTAACAC	0.488000													3	47					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74621540	74621540	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:74621540T>A	ENST00000354431.4	-	4	775	c.584A>T	c.(583-585)tAt>tTt	p.Y195F	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.Y195F|LRRIQ3_ENST00000370909.2_Missense_Mutation_p.Y87F	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	195										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTCCTCTTCATAGGTTGTTCC	0.234000													5	75					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33990146	33990146	+	Silent	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr15:33990146C>T	ENST00000389232.4	+	40	6268	c.6198C>T	c.(6196-6198)caC>caT	p.H2066H	RYR3_ENST00000415757.3_Silent_p.H2066H	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2066	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGGCATGCACGAGACGGTGA	0.488000													36	40					0	0	1	0	0
TLE3	7090	broad.mit.edu	37	15	70358416	70358416	+	Silent	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr15:70358416G>A	ENST00000558939.1	-	7	1891	c.514C>T	c.(514-516)Ctg>Ttg	p.L172L	TLE3_ENST00000559048.1_Silent_p.L177L|TLE3_ENST00000557997.1_Silent_p.L172L|TLE3_ENST00000451782.2_Silent_p.L172L|TLE3_ENST00000558201.1_Silent_p.L178L|TLE3_ENST00000442299.2_Silent_p.L172L|TLE3_ENST00000559929.1_Silent_p.L182L|TLE3_ENST00000559191.1_Intron|TLE3_ENST00000560939.1_Silent_p.L177L|TLE3_ENST00000317509.8_Silent_p.L172L|TLE3_ENST00000557907.1_Silent_p.L172L|TLE3_ENST00000560589.1_Silent_p.L116L|TLE3_ENST00000558379.1_Silent_p.L172L|TLE3_ENST00000539550.1_Silent_p.L116L|TLE3_ENST00000440567.3_Silent_p.L165L	NM_001282979.1|NM_001282980.1|NM_001282981.1	NP_001269908.1|NP_001269909.1|NP_001269910.1	Q04726	TLE3_HUMAN	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	172	Gly/Pro-rich.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TGGCTGCCCAGGGCGCCCAGT	0.692000													8	21					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21605785	21605785	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr19:21605785A>G	ENST00000392288.2	+	4	433	c.324A>G	c.(322-324)atA>atG	p.I108M	ZNF493_ENST00000596302.1_3'UTR|ZNF493_ENST00000355504.4_5'UTR|CTD-2561J22.3_ENST00000600810.1_Intron	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						AAAAAGTGATACTGAGAGAAT	0.313000													65	68					0	0	1	0	0
EXOC5	10640	broad.mit.edu	37	14	57698434	57698434	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr14:57698434C>G	ENST00000413566.2	-	11	1298		c.e11-1		EXOC5_ENST00000340918.7_Splice_Site	NM_006544.3	NP_006535.1	O00471	EXOC5_HUMAN	exocyst complex component 5						exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				breast(3)|endometrium(1)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	22						ATTGGTGGTTCTTTTCATGAA	0.303000													5	33					0	0	1	0	0
RHOA	387	broad.mit.edu	37	3	49412941	49412941	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr3:49412941C>A	ENST00000418115.1	-	2	466	c.82G>T	c.(82-84)Gac>Tac	p.D28Y	RHOA_ENST00000454011.2_Missense_Mutation_p.D28Y|RHOA_ENST00000422781.1_Missense_Mutation_p.D28Y	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	28					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	GGGAACTGGTCCTTGCTGAAG	0.463000													41	113					6.1244e-12	7.06662e-12	1	1	0
CLMN	79789	broad.mit.edu	37	14	95669794	95669794	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr14:95669794G>C	ENST00000298912.4	-	9	2005	c.1892C>G	c.(1891-1893)cCt>cGt	p.P631R		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	631						integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		GTCCTGATGAGGTTCATGTTT	0.443000													8	64					0	0	1	0	0
ZNF510	22869	broad.mit.edu	37	9	99522207	99522207	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr9:99522207G>A	ENST00000375231.1	-	6	1555	c.905C>T	c.(904-906)aCt>aTt	p.T302I	ZNF510_ENST00000223428.4_Missense_Mutation_p.T302I			Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	21		Acute lymphoblastic leukemia(62;0.0527)				CCCTGTGCCAGTTCTCCTGTG	0.353000													42	57					0	0	1	0	0
DDR2	4921	broad.mit.edu	37	1	162749902	162749902	+	Splice_Site	SNP	A	A	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:162749902A>G	ENST00000367922.3	+	19	2872	c.2434A>G	c.(2434-2436)Act>Gct	p.T812A	DDR2_ENST00000367921.3_Splice_Site_p.T812A	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2		Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GTTCCCAAAGACTTACCTCCC	0.428000													12	155					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12957624	12957624	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr8:12957624C>G	ENST00000276297.4	-	9	2631	c.2222G>C	c.(2221-2223)aGc>aCc	p.S741T	DLC1_ENST00000512044.2_Missense_Mutation_p.S338T|DLC1_ENST00000520226.1_Missense_Mutation_p.S230T|DLC1_ENST00000358919.2_Missense_Mutation_p.S304T	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	741	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GCTGCTGCTGCTGGTCTGCGT	0.627000													3	62					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21723422	21723422	+	Silent	SNP	T	T	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr7:21723422T>C	ENST00000328843.6	+	33	5533	c.5502T>C	c.(5500-5502)ttT>ttC	p.F1834F	DNAH11_ENST00000409508.3_Silent_p.F1827F			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1834	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CCCAAGCTTTTACATGGCTGT	0.423000									Kartagener syndrome				120	143					0	0	1	0	0
GRXCR2	643226	broad.mit.edu	37	5	145252241	145252241	+	Silent	SNP	T	T	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:145252241T>G	ENST00000377976.1	-	1	290	c.291A>C	c.(289-291)gcA>gcC	p.A97A		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	97										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						GCTGGCCGCCTGCCAAGGTGT	0.517000													5	55					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987887	50987887	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr22:50987887G>A	ENST00000395676.2	+	1	1426	c.1292G>A	c.(1291-1293)cGc>cAc	p.R431H		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	431										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGGACCCCACGCGCGCCACTC	0.672000													33	26					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176011809	176011809	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:176011809G>T	ENST00000510636.1	+	19	2801	c.2527G>T	c.(2527-2529)Gag>Tag	p.E843*	CDHR2_ENST00000506348.1_Nonsense_Mutation_p.E843*|CDHR2_ENST00000261944.5_Nonsense_Mutation_p.E843*	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	843	Cadherin 8.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						TGCCCAGCTGGAGATACAGCT	0.612000													5	78					0.184627	0.184627	1	1	0
OSMR	9180	broad.mit.edu	37	5	38904526	38904526	+	Silent	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:38904526G>A	ENST00000274276.3	+	9	1608	c.1206G>A	c.(1204-1206)gcG>gcA	p.A402A		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	402	Fibronectin type-III 1.				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					AGTACATGGCGCGAGTACGGT	0.468000													7	49					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95539414	95539414	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr8:95539414C>G	ENST00000297591.5	-	8	1133	c.1058G>C	c.(1057-1059)tGt>tCt	p.C353S	KIAA1429_ENST00000421249.2_Missense_Mutation_p.C353S|KIAA1429_ENST00000437199.1_Missense_Mutation_p.C353S	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	353					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CTTGTATGGACAACTGAAGTA	0.383000													7	106					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22805631	22805631	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr18:22805631C>G	ENST00000361524.3	-	4	2399	c.2251G>C	c.(2251-2253)Gtc>Ctc	p.V751L	ZNF521_ENST00000538137.2_Missense_Mutation_p.V751L|ZNF521_ENST00000584787.1_Missense_Mutation_p.V531L	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	751					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CACCTATAGACTTTCTTTTCG	0.468000			T	PAX5	ALL								8	19					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248343366	248343366	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:248343366C>T	ENST00000359682.2	+	1	79	c.79C>T	c.(79-81)Ctc>Ttc	p.L27F		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACACACGTTCCTCTTCTTTCT	0.493000													90	105					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20530608	20530608	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr4:20530608G>A	ENST00000504154.1	+	16	1751	c.1499G>A	c.(1498-1500)tGc>tAc	p.C500Y	SLIT2_ENST00000273739.5_Missense_Mutation_p.C504Y|SLIT2_ENST00000503837.1_Missense_Mutation_p.C496Y|SLIT2_ENST00000503823.1_Missense_Mutation_p.C492Y	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	500	LRRNT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AGTGGAGACTGCTTTGCGGAT	0.388000													4	109					0	0	1	0	0
IL18R1	8809	broad.mit.edu	37	2	103006643	103006643	+	Nonsense_Mutation	SNP	T	T	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr2:103006643T>G	ENST00000409599.1	+	10	1433	c.1077T>G	c.(1075-1077)taT>taG	p.Y359*	IL18R1_ENST00000233957.1_Nonsense_Mutation_p.Y359*			Q13478	IL18R_HUMAN	interleukin 18 receptor 1	359					innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			breast(1)|endometrium(3)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						TTCTATTTTATAGACATTTAA	0.343000													29	27					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176838029	176838029	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:176838029C>T	ENST00000367654.3	-	22	3833	c.3622G>A	c.(3622-3624)Gag>Aag	p.E1208K	ASTN1_ENST00000367657.3_Missense_Mutation_p.E1200K|ASTN1_ENST00000361833.2_Missense_Mutation_p.E1200K|ASTN1_ENST00000424564.2_Missense_Mutation_p.E1200K	NM_004319.1	NP_004310.1	O14525	ASTN1_HUMAN	astrotactin 1						cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CCAAAACTCTCATAGTGCTGG	0.478000													4	104					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83402613	83402613	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:83402613T>C	ENST00000296591.5	-	6	923	c.505A>G	c.(505-507)Ata>Gta	p.I169V	EDIL3_ENST00000380138.3_Missense_Mutation_p.I159V	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	169	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TGGTTTGATATAATTCCACCT	0.388000													51	39					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62855780	62855780	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr17:62855780G>A	ENST00000584306.1	-	11	5014	c.4484C>T	c.(4483-4485)gCt>gTt	p.A1495V	LRRC37A3_ENST00000400877.3_Missense_Mutation_p.A533V|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.A1495V|LRRC37A3_ENST00000339474.5_Missense_Mutation_p.A613V|LRRC37A3_ENST00000334962.5_Missense_Mutation_p.A472V	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1495						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						GATAACATGAGCAATGAGCCT	0.522000													5	216					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40692965	40692965	+	Silent	SNP	A	A	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr12:40692965A>G	ENST00000298910.7	+	25	3460	c.3402A>G	c.(3400-3402)ttA>ttG	p.L1134L	LRRK2_ENST00000343742.2_Silent_p.L1134L	NM_198578.3	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1134					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TGAAGATTTTAAACCTTAGTA	0.353000													47	32					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730190	140730190	+	Silent	SNP	A	A	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:140730190A>G	ENST00000523390.1	+	1	363	c.363A>G	c.(361-363)caA>caG	p.Q121Q	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTAATCCAAGATATTAATG	0.423000													5	65					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80101302	80101302	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr2:80101302G>A	ENST00000466387.1	+	10	1410	c.686G>A	c.(685-687)cGc>cAc	p.R229H	CTNNA2_ENST00000540488.1_Missense_Mutation_p.R229H|CTNNA2_ENST00000496558.1_Missense_Mutation_p.R229H|CTNNA2_ENST00000361291.4_Missense_Mutation_p.R263H|CTNNA2_ENST00000402739.4_Missense_Mutation_p.R229H|CTNNA2_ENST00000541047.1_Missense_Mutation_p.R229H			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	229					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton	p.R229H(2)		breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						GCATTTCTCCGCCACCCAGAT	0.572000													3	45					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168319521	168319521	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr6:168319521C>T	ENST00000366806.2	+	20	2937	c.2795C>T	c.(2794-2796)cCg>cTg	p.P932L	MLLT4_ENST00000344191.4_Missense_Mutation_p.P932L|MLLT4_ENST00000392108.3_Missense_Mutation_p.P932L|MLLT4_ENST00000447894.2_Missense_Mutation_p.P932L|MLLT4_ENST00000392112.1_Missense_Mutation_p.P916L|MLLT4_ENST00000351017.4_Missense_Mutation_p.P939L|MLLT4_ENST00000400822.3_Missense_Mutation_p.P931L			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	932					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding	p.P932L(1)|p.P916L(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CTGCAGCTGCCGTTTCTTTTG	0.448000			T	MLL	AL								26	27					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P|FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													4	98					0	0	1	0	0
RINT1	60561	broad.mit.edu	37	7	105207606	105207606	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr7:105207606T>G	ENST00000257700.2	+	15	2458	c.2227T>G	c.(2227-2229)Tct>Gct	p.S743A	EFCAB10_ENST00000490493.1_5'UTR|EFCAB10_ENST00000480514.1_Intron|EFCAB10_ENST00000485614.1_Intron|EFCAB10_ENST00000486180.1_3'UTR	NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	743	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						GAACGTCGGTTCTGCACTACT	0.398000													5	78					0	0	1	0	0
NACA2	342538	broad.mit.edu	37	17	59668330	59668330	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr17:59668330C>T	ENST00000521764.1	-	1	233	c.212G>A	c.(211-213)cGg>cAg	p.R71Q		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	71	NAC-A/B.				protein transport	cytoplasm|nucleus				large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					CTTTTCACTCCGACTCTGTTT	0.458000													7	170					0	0	1	0	0
PARS2	25973	broad.mit.edu	37	1	55224597	55224597	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:55224597T>A	ENST00000371279.3	-	2	320	c.238A>T	c.(238-240)Atc>Ttc	p.I80F		NM_152268.3	NP_689481.2	Q7L3T8	SYPM_HUMAN	prolyl-tRNA synthetase 2, mitochondrial (putative)	80					prolyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|proline-tRNA ligase activity			breast(1)|endometrium(3)|kidney(2)|lung(4)|ovary(2)|prostate(2)|skin(1)	15					L-Proline(DB00172)	GCTGGGTAGAtcaggcccacc	0.602000													8	27					0	0	1	0	0
TIMM17A	10440	broad.mit.edu	37	1	201926494	201926494	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:201926494C>T	ENST00000367287.4	+	2	148	c.112C>T	c.(112-114)Cgc>Tgc	p.R38C		NM_006335.2	NP_006326.1	Q99595	TI17A_HUMAN	translocase of inner mitochondrial membrane 17 homolog A (yeast)	38					protein targeting to mitochondrion	integral to membrane|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	p.R38C(1)		kidney(1)|lung(3)|stomach(1)	5						CAAAGGTTTTCGCAATTCTCC	0.453000													23	37					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206607956	206607956	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr2:206607956C>T	ENST00000360409.3	+	9	2112	c.1321C>T	c.(1321-1323)Ctc>Ttc	p.L441F	NRP2_ENST00000357785.5_Missense_Mutation_p.L441F|NRP2_ENST00000540178.1_Missense_Mutation_p.L441F|NRP2_ENST00000272849.3_Missense_Mutation_p.L441F|NRP2_ENST00000540841.1_Missense_Mutation_p.L441F|NRP2_ENST00000417189.1_Missense_Mutation_p.L441F|NRP2_ENST00000412873.2_Missense_Mutation_p.L441F|NRP2_ENST00000357118.4_Missense_Mutation_p.L441F|NRP2_ENST00000355117.4_Missense_Mutation_p.L441F	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	441	F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						GCTGGGGATGCTCTCAGGCCT	0.597000													28	102					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25472257	25472257	+	RNA	SNP	G	G	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr15:25472257G>T	ENST00000453082.2	+	0	1238				SNORD115-31_ENST00000365318.1_RNA	NR_003343.1																						CCCTGGGTTGGGTCAGTGATG	0.527000													6	185					2.0095e-06	2.22362e-06	1	1	0
UACA	55075	broad.mit.edu	37	15	70991872	70991872	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr15:70991872C>A	ENST00000322954.6	-	2	391	c.206G>T	c.(205-207)aGa>aTa	p.R69I	UACA_ENST00000379983.2_Missense_Mutation_p.R56I|UACA_ENST00000560441.1_Missense_Mutation_p.R56I|UACA_ENST00000539319.1_Missense_Mutation_p.R69I	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	69						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						TTACACAGATCTGCCTTCCAC	0.393000													4	68					3.59834e-05	3.825e-05	1	1	0
LRRN4	164312	broad.mit.edu	37	20	6022069	6022069	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr20:6022069G>A	ENST00000378858.4	-	5	2046	c.1822C>T	c.(1822-1824)Cat>Tat	p.H608Y		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	608	Fibronectin type-III.					integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						TGGTACCCATGCACTACCGAG	0.687000													7	40					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113515335	113515335	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr12:113515335T>G	ENST00000257600.3	+	2	869	c.366T>G	c.(364-366)gaT>gaG	p.D122E		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	122	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						CGGCCTACGATATGGACATCT	0.622000													7	210					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2977901	2977901	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr12:2977901G>T	ENST00000342628.2	-	4	787	c.674C>A	c.(673-675)cCa>cAa	p.P225Q	FOXM1_ENST00000361953.3_Missense_Mutation_p.P225Q|FOXM1_ENST00000537018.1_5'UTR|FOXM1_ENST00000359843.3_Missense_Mutation_p.P225Q	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	225					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			GGACGCTGATGGTCTCGAAGG	0.517000													14	56					9.31168e-06	1.00566e-05	1	1	0
PLRG1	5356	broad.mit.edu	37	4	155458437	155458437	+	Splice_Site	SNP	C	C	A	rs1134692		TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr4:155458437C>A	ENST00000499023.2	-	14	1612		c.e14+1		PLRG1_ENST00000302078.5_Splice_Site|PLRG1_ENST00000393905.2_Splice_Site	NM_001201564.1|NM_002669.3	NP_001188493.1|NP_002660.1	O43660	PLRG1_HUMAN	pleiotropic regulator 1							catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|skin(1)|urinary_tract(1)	22	all_hematologic(180;0.215)	Renal(120;0.0854)				ACAGAACTTACGGCTGTGTCA	0.328000													19	20					8.00594e-06	8.71614e-06	1	1	0
ELF3	1999	broad.mit.edu	37	1	201984374	201984374	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:201984374G>A	ENST00000359651.3	+	8	4231	c.1039G>A	c.(1039-1041)Ggc>Agc	p.G347S	ELF3_ENST00000367283.3_Missense_Mutation_p.G347S|ELF3_ENST00000367284.5_Missense_Mutation_p.G347S|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	347					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						ACGGGTGGATGGCCGGCGACT	0.572000													19	38					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155278371	155278371	+	Splice_Site	SNP	T	T	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr4:155278371T>A	ENST00000357232.4	-	6	799	c.800A>T	c.(799-801)aAg>aTg	p.K267M	DCHS2_ENST00000339452.1_Intron	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		taacctctacttgaagtgcct	0.398000													7	163					0	0	1	0	0
PCYOX1	51449	broad.mit.edu	37	2	70502265	70502265	+	Silent	SNP	C	C	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr2:70502265C>G	ENST00000433351.2	+	4	697	c.669C>G	c.(667-669)gtC>gtG	p.V223V	PCYOX1_ENST00000264441.5_Silent_p.V223V|PCYOX1_ENST00000505044.2_Silent_p.V146V|PCYOX1_ENST00000545138.1_Silent_p.V145V	NM_016297.3	NP_057381.3	Q9UHG3	PCYOX_HUMAN	prenylcysteine oxidase 1	223					prenylated protein catabolic process	lysosome|very-low-density lipoprotein particle	prenylcysteine oxidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)	15						TTATGAGGGTCAATTATGGCC	0.458000													4	135					0	0	1	0	0
PPP1R1B	84152	broad.mit.edu	37	17	37785805	37785805	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr17:37785805C>G	ENST00000254079.4	+	3	624	c.155C>G	c.(154-156)tCc>tGc	p.S52C	PPP1R1B_ENST00000394265.1_Missense_Mutation_p.S16C|PPP1R1B_ENST00000579000.1_Intron|PPP1R1B_ENST00000394267.2_Missense_Mutation_p.S16C|PPP1R1B_ENST00000580825.1_Missense_Mutation_p.S52C	NM_032192.3	NP_115568.2	Q9UD71	PPR1B_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1B	52					signal transduction	cytosol	protein kinase inhibitor activity|protein phosphatase inhibitor activity			kidney(1)|large_intestine(1)|liver(1)|lung(2)	5	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GAGGAAGCCTCCCCCCACCAG	0.582000													12	50					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37756913	37756913	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr8:37756913G>A	ENST00000330843.4	-	1	59	c.47C>T	c.(46-48)tCc>tTc	p.S16F	RAB11FIP1_ENST00000287263.4_Missense_Mutation_p.S16F|RAB11FIP1_ENST00000522727.1_5'UTR	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	16	C2.				protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			GTGGGTTGGGGACCACACGGC	0.706000													4	16					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11346541	11346541	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:11346541G>A	ENST00000304623.8	-	9	1760	c.1571C>T	c.(1570-1572)cCg>cTg	p.P524L	CTNND2_ENST00000503622.1_Missense_Mutation_p.P187L|CTNND2_ENST00000359640.2_Missense_Mutation_p.P524L|CTNND2_ENST00000511377.1_Missense_Mutation_p.P433L|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Missense_Mutation_p.P91L	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	524					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GCCTTCAGGCGGGAGAGCAGG	0.542000													47	51					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	274976	274976	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr12:274976C>T	ENST00000538872.1	+	11	3009	c.2891C>T	c.(2890-2892)tCg>tTg	p.S964L	IQSEC3_ENST00000326261.4_Missense_Mutation_p.S964L|RP11-598F7.5_ENST00000540136.1_RNA|IQSEC3_ENST00000382841.2_Missense_Mutation_p.S661L			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	964	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GCCCTGGGCTCGGACGAGATG	0.582000													27	13					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577105	7577105	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr17:7577105G>C	ENST00000420246.2	-	8	965	c.833C>G	c.(832-834)cCt>cGt	p.P278R	TP53_ENST00000359597.4_Missense_Mutation_p.P278R|TP53_ENST00000269305.4_Missense_Mutation_p.P278R|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.P278R|TP53_ENST00000445888.2_Missense_Mutation_p.P278R	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	278	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		P -> A (in sporadic cancers; somatic mutation; dbSNP:rs17849781).|P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> H (in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P278L(61)|p.P278R(30)|p.P278H(13)|p.0?(8)|p.P278F(3)|p.?(2)|p.P278fs*67(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.F270_D281del12(1)|p.V274_P278del(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCTCTCCCAGGACAGGCACA	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	1					0	0	1	0	0
MCAM	4162	broad.mit.edu	37	11	119183299	119183299	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr11:119183299G>A	ENST00000392814.1	-	2	1375	c.646C>T	c.(646-648)Cgc>Tgc	p.R216C	MCAM_ENST00000264036.4_Missense_Mutation_p.R267C			P43121	MUC18_HUMAN	melanoma cell adhesion molecule	267	Ig-like V-type 2.				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|skin(1)	22		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		ATTTCCACGCGGTCCCCTTCC	0.577000													18	62					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777276	18777276	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr9:18777276C>T	ENST00000380548.4	+	19	3388	c.3049C>T	c.(3049-3051)Ccg>Tcg	p.P1017S		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1017						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		GGCCGCCAACCCGGGGAGCCG	0.701000													16	11					0	0	1	0	0
FAM194A	131831	broad.mit.edu	37	3	150387209	150387209	+	Missense_Mutation	SNP	C	C	G	rs143964947		TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr3:150387209C>G	ENST00000295910.6	-	12	1425	c.1373G>C	c.(1372-1374)cGa>cCa	p.R458P	FAM194A_ENST00000491361.1_Missense_Mutation_p.R312P	NM_152394.3	NP_689607.2	Q7L0X2	F194A_HUMAN	family with sequence similarity 194, member A	458										NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GTTGGGCACTCGAATGATGGC	0.413000													41	47					0	0	1	0	0
GPR114	221188	broad.mit.edu	37	16	57608973	57608973	+	Silent	SNP	G	G	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr16:57608973G>T	ENST00000340339.4	+	11	1978	c.1455G>T	c.(1453-1455)ctG>ctT	p.L485L	GPR114_ENST00000394361.4_3'UTR|GPR114_ENST00000349457.3_Silent_p.L485L	NM_153837.1	NP_722579.1	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114	485					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(5)|ovary(2)|stomach(1)|urinary_tract(1)	23						TGCCCCAGCTGTTCCTCTTCA	0.602000													11	29					0.000978159	0.00100803	1	1	0
PATZ1	23598	broad.mit.edu	37	22	31738908	31738908	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr22:31738908G>A	ENST00000266269.5	-	2	1939	c.1310C>T	c.(1309-1311)aCt>aTt	p.T437I	PATZ1_ENST00000405309.3_Missense_Mutation_p.T437I|PATZ1_ENST00000351933.4_Missense_Mutation_p.T437I|PATZ1_ENST00000215919.3_Missense_Mutation_p.T437I	NM_014323.2	NP_055138.2	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	437					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						CCGCTCAGAAGTGTGCACCTG	0.562000													6	67					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103090312	103090312	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr2:103090312G>A	ENST00000295269.4	+	1	551	c.94G>A	c.(94-96)Gaa>Aaa	p.E32K		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	32					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						TGATTTGAATGAATCTGCAAA	0.448000													4	171					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90046431	90046431	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:90046431C>T	ENST00000405460.2	+	53	11134	c.11038C>T	c.(11038-11040)Cgc>Tgc	p.R3680C		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3680					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GAACGTTGAACGCTTAAAAGG	0.383000													26	73					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13602906	13602906	+	Missense_Mutation	SNP	C	C	T	rs34471245		TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr4:13602906C>T	ENST00000040738.5	-	10	5753	c.5618G>A	c.(5617-5619)aGt>aAt	p.S1873N		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1873							DNA binding										TCTTCCAGTACTAGTCACAAC	0.463000													14	47					0	0	1	0	0
ERLEC1	27248	broad.mit.edu	37	2	54028857	54028857	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr2:54028857G>C	ENST00000185150.4	+	8	888	c.757G>C	c.(757-759)Gca>Cca	p.A253P	GPR75-ASB3_ENST00000352846.3_Intron|ERLEC1_ENST00000378239.5_Missense_Mutation_p.A253P|ASB3_ENST00000406625.2_Intron|ERLEC1_ENST00000405123.3_Missense_Mutation_p.A253P|ASB3_ENST00000498475.2_Intron	NM_015701.4	NP_056516.2	Q96DZ1	ERLEC_HUMAN	endoplasmic reticulum lectin 1	253					ER-associated protein catabolic process	endoplasmic reticulum lumen	glycoprotein binding|protein binding			endometrium(2)|large_intestine(4)|lung(8)|ovary(2)|stomach(1)|urinary_tract(1)	18						CAGGTTCAGAGCATCTCCTGT	0.413000													20	65					0	0	1	0	0
HMGCS1	3157	broad.mit.edu	37	5	43293062	43293062	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:43293062A>T	ENST00000325110.6	-	9	1403	c.1197T>A	c.(1195-1197)gaT>gaA	p.D399E	HMGCS1_ENST00000433297.2_Missense_Mutation_p.D399E	NM_001098272.2	NP_001091742.1	Q01581	HMCS1_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	399					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|stomach(1)|urinary_tract(1)	15						CTGTTATTTTATCAAGAGCAG	0.353000													7	139					0	0	1	0	0
IFT88	8100	broad.mit.edu	37	13	21175923	21175923	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr13:21175923A>G	ENST00000382778.4	+	13	2037	c.919A>G	c.(919-921)Ata>Gta	p.I307V	IFT88_ENST00000319980.6_Missense_Mutation_p.I307V|IFT88_ENST00000351808.5_Missense_Mutation_p.I298V|IFT88_ENST00000537103.1_Missense_Mutation_p.I279V			Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog (Chlamydomonas)	307					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	27		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		ATATGAGCACATAATGAGCAT	0.343000													9	39					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921416	24921416	+	Silent	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr15:24921416G>A	ENST00000329468.2	+	1	876	c.402G>A	c.(400-402)gcG>gcA	p.A134A		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GTGAGCCGGCGGTCAAGGCCA	0.632000													15	27					0	0	1	0	0
ACSS2	55902	broad.mit.edu	37	20	33509215	33509215	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr20:33509215G>A	ENST00000360596.2	+	11	1571	c.1360G>A	c.(1360-1362)Gta>Ata	p.V454I	ACSS2_ENST00000476922.1_Intron|ACSS2_ENST00000253382.5_Missense_Mutation_p.V467I|ACSS2_ENST00000336325.4_Missense_Mutation_p.V404I	NM_018677.3	NP_061147.1	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	454					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(9)	21					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCACCGGGTGGTAGGTGCCCA	0.607000													20	34					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64537059	64537059	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr11:64537059C>T	ENST00000377390.3	-	6	839	c.502G>A	c.(502-504)Gag>Aag	p.E168K	SF1_ENST00000489544.1_5'UTR|SF1_ENST00000433274.2_Missense_Mutation_p.E142K|SF1_ENST00000422298.2_Missense_Mutation_p.E53K|SF1_ENST00000227503.9_Missense_Mutation_p.E168K|SF1_ENST00000334944.5_Missense_Mutation_p.E168K|SF1_ENST00000377387.1_Missense_Mutation_p.E293K|SF1_ENST00000377394.3_Missense_Mutation_p.E168K	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	168	KH.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						CACTCCTTCTCTATGTTCTTC	0.478000													53	73					0	0	1	0	0
NAGA	4668	broad.mit.edu	37	22	42464511	42464511	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr22:42464511C>G	ENST00000396398.3	-	2	616	c.84G>C	c.(82-84)atG>atC	p.M28I	NAGA_ENST00000403363.1_Missense_Mutation_p.M28I|NAGA_ENST00000402937.1_Missense_Mutation_p.M28I	NM_000262.2	NP_000253.1	P17050	NAGAB_HUMAN	N-acetylgalactosaminidase, alpha-	28					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						CCAGCCAGCCCATGGGTGGTG	0.572000													13	61					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95670021	95670021	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr14:95670021A>T	ENST00000298912.4	-	9	1778	c.1665T>A	c.(1663-1665)taT>taA	p.Y555*		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	555						integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		TGGCTTCAAAATAGTCTCCCT	0.433000													31	49					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152327055	152327055	+	Silent	SNP	A	A	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:152327055A>G	ENST00000388718.5	-	3	3279	c.3207T>C	c.(3205-3207)tcT>tcC	p.S1069S	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1069	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACGTGATCTAGACTCATATT	0.473000													8	397					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573467	140573467	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:140573467G>A	ENST00000239446.4	+	1	1526	c.1342G>A	c.(1342-1344)Gcc>Acc	p.A448T		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		448	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAATGACAACGCCCCCGCCTT	0.597000													5	88					0	0	1	0	0
SH2D6	284948	broad.mit.edu	37	2	85663644	85663644	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr2:85663644T>C	ENST00000389938.2	+	20	1685	c.371T>C	c.(370-372)cTt>cCt	p.L124P	SH2D6_ENST00000340326.2_Missense_Mutation_p.L156P|SH2D6_ENST00000481426.2_3'UTR			Q7Z4S9	SH2D6_HUMAN	SH2 domain containing 6	156	SH2.									central_nervous_system(1)|lung(2)	3						CCTCTGCCCCTTGTGGACAGA	0.637000													21	16					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186099685	186099685	+	Silent	SNP	A	A	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:186099685A>C	ENST00000271588.4	+	85	13315	c.13086A>C	c.(13084-13086)ccA>ccC	p.P4362P	HMCN1_ENST00000367492.2_Silent_p.P4362P	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4362	Ig-like C2-type 43.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GGATTGAACCACTTGGTGGGA	0.418000													42	61					0	0	1	0	0
PTGER3	5733	broad.mit.edu	37	1	71318532	71318532	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:71318532C>A	ENST00000370932.2	-	3	1318	c.1088G>T	c.(1087-1089)tGg>tTg	p.W363L	PTGER3_ENST00000351052.5_3'UTR|PTGER3_ENST00000370931.3_3'UTR|PTGER3_ENST00000460330.1_Missense_Mutation_p.W372L	NM_198717.1	NP_942010.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	363					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	TTAATTTCCCCAAAATTCCTC	0.338000													6	201					0.0381472	0.0387209	1	1	0
CACNA1S	779	broad.mit.edu	37	1	201020186	201020186	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:201020186C>T	ENST00000362061.3	-	33	4265	c.4039G>A	c.(4039-4041)Ggg>Agg	p.G1347R	CACNA1S_ENST00000367338.3_Missense_Mutation_p.G1328R	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1347	Dihydropyridine binding (By similarity).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TACTCCTCCCCTGGGGCATAG	0.562000													31	43					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95657940	95657940	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr14:95657940G>T	ENST00000298912.4	-	13	3083	c.2970C>A	c.(2968-2970)tgC>tgA	p.C990*	CLMN_ENST00000556441.1_Nonsense_Mutation_p.C55*|CLMN_ENST00000557215.1_5'UTR	NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	990						integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		AGAGCAGCAAGCAGTACACCA	0.517000													4	33					0.014758	0.0150934	1	1	0
SRCAP	10847	broad.mit.edu	37	16	30715473	30715473	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr16:30715473C>T	ENST00000262518.4	+	4	528	c.143C>T	c.(142-144)cCg>cTg	p.P48L	SRCAP_ENST00000344771.4_Missense_Mutation_p.P48L|SRCAP_ENST00000395059.2_Missense_Mutation_p.P48L	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	48					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity	p.P48Q(1)		NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			GGCATCTCCCCGCAGCACATA	0.612000													26	54					0	0	1	0	0
PDIK1L	149420	broad.mit.edu	37	1	26448508	26448508	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:26448508C>A	ENST00000374271.4	+	4	753	c.466C>A	c.(466-468)Cat>Aat	p.H156N	PDIK1L_ENST00000374269.1_Missense_Mutation_p.H156N	NM_001243532.1|NM_001243533.1|NM_152835.4	NP_001230461.1|NP_001230462.1|NP_690048.1	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	156	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity			large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	7		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		GGCTTTCTTGCATAAAAACCA	0.458000													6	144					3.59834e-05	3.825e-05	1	1	0
WWC3	55841	broad.mit.edu	37	X	10046915	10046915	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chrX:10046915G>A	ENST00000380861.4	+	4	688	c.297G>A	c.(295-297)agG>agA	p.R99R	WWC3_ENST00000454666.1_Splice_Site_p.R99R	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	99										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						GTCGGGATAGGGTGAGTAAAA	0.438000													8	33					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150712821	150712821	+	Silent	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:150712821G>A	ENST00000335244.4	-	7	936	c.807C>T	c.(805-807)ttC>ttT	p.F269F	SLC36A2_ENST00000521967.1_Silent_p.F269F	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	269					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGCTGTTCCGAAGAAGAGAG	0.458000													20	43					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43268275	43268275	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr19:43268275G>T	ENST00000404209.4	-	2	319	c.223C>A	c.(223-225)Ctc>Atc	p.L75I	PSG8_ENST00000401467.2_Missense_Mutation_p.L75I|PSG8_ENST00000306511.4_Missense_Mutation_p.L75I|PSG8_ENST00000406636.3_Intron	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	75	Ig-like V-type.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				TAATGGTAGAGGTCCCTGATT	0.423000													7	284					1.06961e-07	1.21343e-07	1	1	0
ADCY1	107	broad.mit.edu	37	7	45719327	45719327	+	Silent	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr7:45719327C>T	ENST00000297323.7	+	11	1940	c.1918C>T	c.(1918-1920)Ctg>Ttg	p.L640L		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	640					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	CGTCCTGCTCCTGCTAGTATT	0.567000													14	48					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10207138	10207138	+	Missense_Mutation	SNP	G	G	A	rs147329205		TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:10207138G>A	ENST00000377157.3	+	18	2907	c.1846G>A	c.(1846-1848)Gca>Aca	p.A616T	UBE4B_ENST00000343090.6_Missense_Mutation_p.A861T|UBE4B_ENST00000253251.8_Missense_Mutation_p.A732T	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	861					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding	p.A732T(1)|p.A861T(1)		NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		CCTGGACCCCGCATATCCCGA	0.493000													4	153					0	0	1	0	0
RPE	6120	broad.mit.edu	37	2	210881288	210881288	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr2:210881288C>G	ENST00000359429.6	+	4	497	c.400C>G	c.(400-402)Cag>Gag	p.Q134E	RPE_ENST00000540255.1_Missense_Mutation_p.Q134E|RPE_ENST00000445268.1_Missense_Mutation_p.Q66E|RPE_ENST00000454822.1_Missense_Mutation_p.Q84E|RPE_ENST00000438204.2_Missense_Mutation_p.Q66E|RPE_ENST00000436630.2_Missense_Mutation_p.Q84E|RPE_ENST00000435437.2_Missense_Mutation_p.Q134E|RPE_ENST00000452025.1_Missense_Mutation_p.Q134E|RPE_ENST00000354506.6_Missense_Mutation_p.Q126E|RPE_ENST00000411934.2_Missense_Mutation_p.Q66E|RPE_ENST00000429921.1_Missense_Mutation_p.Q84E|RPE_ENST00000429907.1_Missense_Mutation_p.Q66E	NM_199229.1	NP_954699.1	Q96AT9	RPE_HUMAN	ribulose-5-phosphate-3-epimerase	134					pentose-phosphate shunt	cytosol	metal ion binding|protein homodimerization activity|ribulose-phosphate 3-epimerase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(2)	9				Epithelial(149;0.00241)|Lung(261;0.041)|all cancers(144;0.0429)|LUSC - Lung squamous cell carcinoma(261;0.0431)		ATGGGCTAATCAGATAGATAT	0.408000													28	54					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73047240	73047240	+	RNA	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chrX:73047240G>A	ENST00000604411.1	+	0	35201				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						AAGGTGAGTAGAAAGGGAAGA	0.398000													11	2					0	0	1	0	0
NKX2-2	4821	broad.mit.edu	37	20	21494155	21494155	+	Silent	SNP	G	G	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr20:21494155G>T	ENST00000377142.4	-	1	509	c.153C>A	c.(151-153)ggC>ggA	p.G51G		NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	51					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						CGTCCAGGGCGCCCTGCCCCA	0.692000													11	22					2.27111e-07	2.555e-07	1	1	0
SLC25A20	788	broad.mit.edu	37	3	48899981	48899981	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr3:48899981T>A	ENST00000319017.4	-	5	727	c.529A>T	c.(529-531)Atg>Ttg	p.M177L	SLC25A20_ENST00000544097.1_Missense_Mutation_p.M127L|SLC25A20_ENST00000430379.1_Missense_Mutation_p.M104L	NM_000387.5	NP_000378.1	O43772	MCAT_HUMAN	solute carrier family 25 (carnitine/acylcarnitine translocase), member 20	177					carnitine shuttle|cellular lipid metabolic process|regulation of fatty acid oxidation	integral to membrane|mitochondrial inner membrane	acyl carnitine transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.000168)|Kidney(197;0.00231)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	L-Carnitine(DB00583)	TTACCTCGCATAAGGGTAAGC	0.527000													14	46					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124399768	124399768	+	Silent	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr10:124399768C>T	ENST00000338354.3	+	52	6874	c.6768C>T	c.(6766-6768)aaC>aaT	p.N2256N	DMBT1_ENST00000359586.6_Silent_p.N976N|DMBT1_ENST00000330163.4_Silent_p.N1628N|DMBT1_ENST00000344338.3_Silent_p.N2246N|DMBT1_ENST00000368956.2_Silent_p.N1628N|DMBT1_ENST00000368909.3_Silent_p.N2256N|DMBT1_ENST00000368955.3_Silent_p.N2246N			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2256	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTGACGTGAACATTTCCTTTT	0.473000													35	51					0	0	1	0	0
SGOL1	151648	broad.mit.edu	37	3	20216138	20216138	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr3:20216138T>A	ENST00000412997.1	-	6	1236	c.885A>T	c.(883-885)aaA>aaT	p.K295N	SGOL1-AS1_ENST00000448208.1_RNA|SGOL1_ENST00000442720.1_Intron|SGOL1_ENST00000429446.3_Intron|SGOL1-AS1_ENST00000441442.1_RNA|SGOL1_ENST00000437051.1_Intron|SGOL1_ENST00000263753.4_Missense_Mutation_p.K295N|SGOL1_ENST00000412868.1_Missense_Mutation_p.K295N|SGOL1_ENST00000417364.1_Intron|SGOL1_ENST00000425061.1_Intron|SGOL1_ENST00000443724.1_Intron|SGOL1_ENST00000306698.2_Intron|SGOL1_ENST00000452020.1_Intron|SGOL1_ENST00000421451.1_Missense_Mutation_p.K295N|SGOL1_ENST00000419233.2_Intron|SGOL1_ENST00000383774.1_Intron	NM_001199251.1	NP_001186180.1	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 (S. pombe)	295					attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding			kidney(1)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(2)	14						tagcttttcttttctcttctc	0.284000													4	53					0	0	1	0	0
DUSP3	1845	broad.mit.edu	37	17	41847127	41847127	+	Silent	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr17:41847127G>A	ENST00000226004.3	-	3	471	c.408C>T	c.(406-408)atC>atT	p.I136I	DUSP3_ENST00000397937.2_Silent_p.I95I	NM_004090.3	NP_004081.1	P51452	DUS3_HUMAN	dual specificity phosphatase 3	136	Tyrosine-protein phosphatase.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of JNK cascade|negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|immunological synapse|nucleoplasm	MAP kinase phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	7		Breast(137;0.00725)		BRCA - Breast invasive adenocarcinoma(366;0.116)		TGAGGTAGGCGATAACTAGCG	0.612000													20	16					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59112715	59112715	+	Silent	SNP	A	A	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr14:59112715A>T	ENST00000395153.3	+	4	1410	c.1263A>T	c.(1261-1263)ccA>ccT	p.P421P	DACT1_ENST00000556859.1_Silent_p.P177P|DACT1_ENST00000335867.4_Silent_p.P458P|DACT1_ENST00000541264.2_Silent_p.P177P	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	458					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						CGGCCAAGCCAGCCTCGCAAG	0.612000													11	23					0	0	1	0	0
VPS8	23355	broad.mit.edu	37	3	184550478	184550478	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr3:184550478C>G	ENST00000287546.4	+	4	395	c.224C>G	c.(223-225)aCt>aGt	p.T75S	VPS8_ENST00000424463.2_Splice_Site_p.T75S|VPS8_ENST00000437079.3_Splice_Site_p.T75S|VPS8_ENST00000436792.2_Splice_Site_p.T75S|VPS8_ENST00000446204.2_Splice_Site_p.T75S	NM_015303.3	NP_056118.2	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	75							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			CCAATTTAGACTGATGATGAA	0.343000													6	45					0	0	1	0	0
KLF3	51274	broad.mit.edu	37	4	38691479	38691479	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr4:38691479C>T	ENST00000261438.5	+	4	979	c.674C>T	c.(673-675)cCc>cTc	p.P225L	KLF3_ENST00000514033.1_Missense_Mutation_p.P225L	NM_016531.5	NP_057615.3	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	225	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(5)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18						TCAGTGTCCCCCCCGCAAGCA	0.418000													70	94					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228434442	228434442	+	Translation_Start_Site	SNP	A	A	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:228434442A>T	ENST00000366707.4	+	0	4015				OBSCN_ENST00000570156.2_Missense_Mutation_p.D1416V|OBSCN_ENST00000366709.4_De_novo_Start_OutOfFrame|OBSCN_ENST00000422127.1_Missense_Mutation_p.D1324V|OBSCN_ENST00000284548.11_Missense_Mutation_p.D1324V			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF						apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGCCAGGCAGATGCTGGGGAG	0.592000													35	60					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62729908	62729908	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr20:62729908T>C	ENST00000349451.3	+	6	1281	c.869T>C	c.(868-870)gTt>gCt	p.V290A	OPRL1_ENST00000355631.4_Missense_Mutation_p.V290A|OPRL1_ENST00000336866.2_Missense_Mutation_p.V290A	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	290					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GGGCTGGGGGTTCAGCCGAGC	0.647000													35	18					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6692376	6692376	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr12:6692376G>C	ENST00000309577.6	-	26	4211	c.4048C>G	c.(4048-4050)Cag>Gag	p.Q1350E	CHD4_ENST00000544484.1_Missense_Mutation_p.Q1347E|CHD4_ENST00000540960.1_5'UTR|CHD4_ENST00000544040.1_Missense_Mutation_p.Q1343E|CHD4_ENST00000357008.2_Missense_Mutation_p.Q1350E|RP5-940J5.6_ENST00000501075.2_RNA			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1350					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CGGTCCTCCTGGGAGCCATCA	0.582000													5	122					0	0	1	0	0
DDX17	10521	broad.mit.edu	37	22	38902219	38902219	+	Silent	SNP	C	C	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr22:38902219C>A	ENST00000396821.3	-	1	123	c.24G>T	c.(22-24)ccG>ccT	p.P8P	DDX17_ENST00000381633.3_5'UTR|DDX17_ENST00000432525.1_Intron	NM_001098504.1|NM_006386.4	NP_001091974|NP_006377.2	Q92841	DDX17_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 17	0					RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	25	Melanoma(58;0.0286)					CACAGAGAATCGGGGCTACAA	0.657000													2	0					0.0784	0.0789851	1	1	0
HYOU1	10525	broad.mit.edu	37	11	118918677	118918677	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr11:118918677T>C	ENST00000404233.3	-	21	2616	c.2492A>G	c.(2491-2493)cAt>cGt	p.H831R	HYOU1_ENST00000529972.1_Missense_Mutation_p.H769R|HYOU1_ENST00000525859.1_Missense_Mutation_p.H769R	NM_001130991.1|NM_006389.3	NP_001124463.1|NP_006380.1	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1	831						endoplasmic reticulum lumen	ATP binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(10)|prostate(1)|skin(2)	33	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		CATGCTGGAATGGTTGAGGAG	0.562000													20	19					0	0	1	0	0
GRB10	2887	broad.mit.edu	37	7	50771572	50771572	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr7:50771572C>A	ENST00000403097.1	-	4	847	c.67G>T	c.(67-69)Gac>Tac	p.D23Y	GRB10_ENST00000406641.1_5'UTR|GRB10_ENST00000407526.1_5'UTR|GRB10_ENST00000398812.2_Missense_Mutation_p.D29Y|GRB10_ENST00000398810.2_5'UTR|GRB10_ENST00000335866.3_5'UTR|GRB10_ENST00000402497.1_5'UTR|GRB10_ENST00000402578.1_Intron|GRB10_ENST00000401949.1_Missense_Mutation_p.D29Y|GRB10_ENST00000439599.1_Missense_Mutation_p.D23Y|GRB10_ENST00000357271.5_Missense_Mutation_p.D29Y			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	29					insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					CCTGCCGGGTCTTGTTGACTG	0.522000									Russell-Silver syndrome				27	112					7.53681e-25	8.77129e-25	1	1	0
CREB5	9586	broad.mit.edu	37	7	28610119	28610119	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr7:28610119T>A	ENST00000357727.2	+	5	818	c.428T>A	c.(427-429)gTc>gAc	p.V143D	CREB5_ENST00000396300.2_Missense_Mutation_p.V136D|CREB5_ENST00000409603.1_Missense_Mutation_p.V110D|CREB5_ENST00000396299.2_Missense_Mutation_p.V110D	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	143					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						TCCAGCTCTGTCATCACTCAG	0.612000													13	36					0	0	1	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140865370	140865370	+	Silent	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:140865370G>A	ENST00000306593.1	+	1	630	c.630G>A	c.(628-630)ctG>ctA	p.L210L	PCDHGA9_ENST00000573521.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA8_ENST00000398604.2_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTACCGCCTGGTGCTGACTG	0.612000													19	11					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102901240	102901240	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr14:102901240A>G	ENST00000359520.7	+	9	2312	c.2086A>G	c.(2086-2088)Aat>Gat	p.N696D	TECPR2_ENST00000558678.1_Missense_Mutation_p.N696D	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	696							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						CCTCAGCACAAATCTCTGGCA	0.572000													4	34					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141114043	141114043	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr2:141114043G>T	ENST00000389484.3	-	75	12369	c.11398C>A	c.(11398-11400)Cct>Act	p.P3800T		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3800					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATTCAGTAGGAGCTGGGATT	0.308000										TSP Lung(27;0.18)			6	47					8.12818e-05	8.57269e-05	1	1	0
ANK2	287	broad.mit.edu	37	4	114195742	114195742	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr4:114195742G>C	ENST00000357077.4	+	15	1673	c.1620G>C	c.(1618-1620)gaG>gaC	p.E540D	ANK2_ENST00000394537.3_Missense_Mutation_p.E540D|ANK2_ENST00000264366.6_Missense_Mutation_p.E540D|ANK2_ENST00000506722.1_Missense_Mutation_p.E519D	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	540					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGCCCGGGAGGGCCAGGTGG	0.517000													24	79					0	0	1	0	0
KIR2DL3	3804	broad.mit.edu	37	19	55253675	55253675	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr19:55253675C>T	ENST00000342376.3	+	3	351	c.320C>T	c.(319-321)tCc>tTc	p.S107F	KIR3DL1_ENST00000541392.1_Intron|KIR2DL3_ENST00000434419.2_Missense_Mutation_p.S107F|CTB-61M7.1_ENST00000400864.3_RNA|KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000538269.1_Intron	NM_015868.2	NP_056952.2			killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3											breast(1)|cervix(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	21				GBM - Glioblastoma multiforme(193;0.0192)		GTTACTCACTCCCCCTATCAG	0.527000													48	69					0	0	1	0	0
MTHFD2P1	100287639	broad.mit.edu	37	3	95374340	95374340	+	RNA	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr3:95374340G>A	ENST00000494840.1	-	0	1521					NR_077228.1																						TGGGGTAGCCGGTAACATGGA	0.433000													21	45					0	0	1	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925207	67925207	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr11:67925207A>G	ENST00000304363.4	-	11	2959	c.2606T>C	c.(2605-2607)aTt>aCt	p.I869T		NM_017635.3	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	869					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						AGAAATGTCAATATCTATAGA	0.368000													41	33					0	0	1	0	0
ZW10	9183	broad.mit.edu	37	11	113628414	113628414	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr11:113628414C>T	ENST00000200135.3	-	7	1039	c.895G>A	c.(895-897)Gta>Ata	p.V299I		NM_004724.3	NP_004715.1	O43264	ZW10_HUMAN	zw10 kinetochore protein	299	Interaction with RINT1.				cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	18		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		ACTTCTAGTACCAGTCTGATC	0.318000													41	66					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43233508	43233508	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr19:43233508A>T	ENST00000327495.5	-	5	1194	c.1010T>A	c.(1009-1011)aTt>aAt	p.I337N	PSG3_ENST00000595140.1_Missense_Mutation_p.I337N	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	337	Ig-like C2-type 3.			Missing (in Ref. 9).	defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				TGAAGGGTAAATTCTGGGGAG	0.483000													4	184					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48132526	48132526	+	Missense_Mutation	SNP	T	T	C	rs147988756		TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr12:48132526T>C	ENST00000405493.2	-	25	2556	c.2347A>G	c.(2347-2349)Att>Gtt	p.I783V	RAPGEF3_ENST00000449771.2_Missense_Mutation_p.I825V|RAPGEF3_ENST00000548919.1_Missense_Mutation_p.I716V|RAPGEF3_ENST00000549151.1_Missense_Mutation_p.I783V|RP1-197B17.3_ENST00000547799.1_lincRNA|RAPGEF3_ENST00000389212.3_Missense_Mutation_p.I825V|RAPGEF3_ENST00000171000.4_Missense_Mutation_p.I783V	NM_001098532.2|NM_006105.5	NP_001092002|NP_006096	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	783					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		CCCTCATGAATGAAGGTCATG	0.488000													22	56					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43191839	43191839	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr6:43191839C>T	ENST00000252050.4	+	40	7375	c.7291C>T	c.(7291-7293)Cgg>Tgg	p.R2431W	CUL9_ENST00000372647.2_Missense_Mutation_p.R2403W|CUL9_ENST00000354495.3_Missense_Mutation_p.R2321W	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	2431					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						CCAGGATTTCCGGGTTGGTCT	0.577000													50	61					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433441	140433441	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:140433441C>A	ENST00000306549.3	+	1	2463	c.2386C>A	c.(2386-2388)Ccc>Acc	p.P796T		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		796					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCAGTTTGCCCCCAAATTC	0.453000													14	46					2.32078e-09	2.65513e-09	1	1	0
SLC6A7	6534	broad.mit.edu	37	5	149578798	149578798	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr5:149578798G>A	ENST00000230671.2	+	5	963	c.592G>A	c.(592-594)Gtc>Atc	p.V198I	SLC6A7_ENST00000524041.1_Missense_Mutation_p.V198I	NM_014228.3	NP_055043.2	Q99884	SC6A7_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 7	198						integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)|stomach(1)	16		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	CAGCCGCTACGTCCTCCACAT	0.627000													20	41					0	0	1	0	0
CKM	1158	broad.mit.edu	37	19	45810804	45810804	+	Silent	SNP	G	G	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr19:45810804G>T	ENST00000221476.3	-	7	1056	c.882C>A	c.(880-882)ggC>ggA	p.G294G		NM_001824.4	NP_001815.2	P06732	KCRM_HUMAN	creatine kinase, muscle	294	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			cervix(1)|endometrium(1)|large_intestine(8)|lung(3)|prostate(2)|skin(2)	17		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)	TCACATGCACGCCTCCACGCA	0.607000													17	18					3.32936e-07	3.71457e-07	1	1	0
LRRC37A3	374819	broad.mit.edu	37	17	62856914	62856914	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr17:62856914G>T	ENST00000584306.1	-	11	3880	c.3350C>A	c.(3349-3351)aCc>aAc	p.T1117N	LRRC37A3_ENST00000400877.3_Missense_Mutation_p.T155N|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.T1117N|LRRC37A3_ENST00000339474.5_Missense_Mutation_p.T235N|LRRC37A3_ENST00000334962.5_Missense_Mutation_p.T94N	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1117						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TAGTGTACTGGTAACATCACT	0.463000													12	273					5.50884e-06	6.04628e-06	1	1	0
PIBF1	10464	broad.mit.edu	37	13	73539538	73539538	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr13:73539538G>A	ENST00000326291.6	+	15	2298	c.1960G>A	c.(1960-1962)Gtc>Atc	p.V654I		NM_006346.2	NP_006337.2	Q8WXW3	PIBF1_HUMAN	progesterone immunomodulatory binding factor 1	654						centrosome				breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		TGAGAAAGATGTCAGGTAAAC	0.358000													5	41					0	0	1	0	0
GPER1	2852	broad.mit.edu	37	7	1132273	1132273	+	Silent	SNP	C	C	T			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr7:1132273C>T	ENST00000397092.1	+	3	1793	c.909C>T	c.(907-909)ccC>ccT	p.P303P	C7orf50_ENST00000397100.2_Intron|C7orf50_ENST00000357429.6_Intron|GPER1_ENST00000297469.3_Silent_p.P303P|C7orf50_ENST00000397098.3_Intron|C7orf50_ENST00000488073.1_Intron|GPER1_ENST00000397088.3_Silent_p.P303P|GPER1_ENST00000401670.1_Silent_p.P303P	NM_001039966.1	NP_001035055.1			G protein-coupled estrogen receptor 1	303																	ATGCCCACCCCCTCACGGGCC	0.632000													4	75					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64537455	64537455	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr11:64537455C>G	ENST00000377390.3	-	5	797	c.460G>C	c.(460-462)Ggg>Cgg	p.G154R	SF1_ENST00000433274.2_Missense_Mutation_p.G128R|SF1_ENST00000422298.2_Missense_Mutation_p.G39R|SF1_ENST00000227503.9_Missense_Mutation_p.G154R|SF1_ENST00000334944.5_Missense_Mutation_p.G154R|SF1_ENST00000377387.1_Missense_Mutation_p.G279R|SF1_ENST00000377394.3_Missense_Mutation_p.G154R	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	154	KH.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						ATGAGCAGCCCCACAAAGTTG	0.473000													26	31					0	0	1	0	0
OR5V1	81696	broad.mit.edu	37	6	29323384	29323384	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr6:29323384A>C	ENST00000377154.1	-	4	888	c.589T>G	c.(589-591)Ttg>Gtg	p.L197V	OR5V1_ENST00000543825.1_Missense_Mutation_p.L197V			Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V, member 1	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(3)|large_intestine(3)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						AGCAGTGCCAACTCATTGACA	0.448000													34	30					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101016294	101016294	+	Silent	SNP	T	T	C			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr8:101016294T>C	ENST00000360863.6	-	17	2681	c.2487A>G	c.(2485-2487)ttA>ttG	p.L829L	RGS22_ENST00000519421.1_5'UTR|RGS22_ENST00000523287.1_Silent_p.L648L|RGS22_ENST00000523437.1_Silent_p.L817L	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	829					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TAGAGAGTGATAAAATGCCAG	0.338000													4	59					0	0	1	0	0
XKR3	150165	broad.mit.edu	37	22	17265129	17265129	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr22:17265129C>A	ENST00000331428.5	-	4	862	c.760G>T	c.(760-762)Gca>Tca	p.A254S		NM_175878.3	NP_787074.2	Q5GH77	XKR3_HUMAN	XK, Kell blood group complex subunit-related family, member 3	254						integral to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ATGAAAAATGCCAGAGTCACT	0.418000													3	40					0.00024832	0.000257871	1	1	0
SPAG17	200162	broad.mit.edu	37	1	118624236	118624257	+	Frame_Shift_Del	DEL	CTCGTTCTACTTCATTCCAGCT	CTCGTTCTACTTCATTCCAGCT	-			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr1:118624236_118624257delCTCGTTCTACTTCATTCCAGCT	ENST00000336338.5	-	14	1836_1857	c.1771_1792delAGCTGGAATGAAGTAGAACGAG	c.(1771-1794)agctggaatgaagtagaacgagccfs	p.SWNEVERA591fs		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	591						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ACCTTGAAGGCTCGTTCTACTTCATTCCAGCTCAAGACATCT	0.446													17	61	---	---	---	---					
SOX2	6657	broad.mit.edu	37	3	181430399	181430399	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr3:181430399delA	ENST00000325404.1	+	1	678	c.251delA	c.(250-252)gagfs	p.E84fs	SOX2_ENST00000431565.2_Frame_Shift_Del_p.E84fs	NM_003106.3	NP_003097.1	P48431	SOX2_HUMAN	SRY (sex determining region Y)-box 2	84					cell cycle arrest|chromatin organization|eye development|glial cell fate commitment|inner ear development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of neuron differentiation|osteoblast differentiation|pituitary gland development|positive regulation of MAPKKK cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of caspase activity|response to growth factor stimulus|response to wounding|somatic stem cell maintenance	cytosol|transcription factor complex	miRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(1)|skin(1)	10	all_cancers(143;1.22e-16)|Ovarian(172;0.0283)		all cancers(12;1.82e-48)|Epithelial(37;9.85e-40)|OV - Ovarian serous cystadenocarcinoma(80;7.37e-23)|Lung(8;2.01e-21)|GBM - Glioblastoma multiforme(1;2.13e-08)			CTTTTGTCGGAGACGGAGAAG	0.622			A		"""NSCLC, oesophageal squamous carcinoma"""		MICROPHTHALMIA AND ESOPHAGEAL ATRESIA SYNDROME						10	50	---	---	---	---					
FOLH1B	219595	broad.mit.edu	37	11	89405323	89405326	+	RNA	DEL	TTTA	TTTA	-	rs34562444		TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr11:89405323_89405326delTTTA	ENST00000532352.1	+	0	1114							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						aattatattgtttatttatttttg	0.230													2	4	---	---	---	---					
TSFM	10102	broad.mit.edu	37	12	58190132	58190133	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr12:58190132_58190133delCC	ENST00000454289.3	+	6	957_958	c.744_745delCC	c.(742-747)aaccttfs	p.L249fs	TSFM_ENST00000323833.8_Frame_Shift_Del_p.L270fs|TSFM_ENST00000497617.1_3'UTR|TSFM_ENST00000550559.1_Intron|TSFM_ENST00000548851.1_Intron|TSFM_ENST00000350762.5_Frame_Shift_Del_p.L209fs|TSFM_ENST00000540550.1_3'UTR|TSFM_ENST00000543727.1_Intron	NM_005726.5	NP_005717.3	P43897	EFTS_HUMAN	Ts translation elongation factor, mitochondrial	249					regulation of transcription elongation, DNA-dependent	mitochondrion|nucleus	translation elongation factor activity			endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)	8	all_cancers(7;6.31e-80)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					AGAAAACAAACCTTGAAGACGT	0.584													14	5	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102312241	102312241	+	RNA	DEL	A	A	-	rs59860046		TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr15:102312241delA	ENST00000561463.1	+	0	13609																											AGTGGCCGGGAAATTTGCTGT	0.592													2	4	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-ZF-A9RM-01A-11D-A38G-08	TCGA-ZF-A9RM-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8c0c71e-7cb7-4da7-8f9a-367095bb8ad6	b9f39f0b-4819-40d3-9d2e-8c5151d87c47	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													2	4	---	---	---	---					
