Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
RPL22	6146	broad.mit.edu	37	1	6257784	6257785	+	Frame_Shift_Ins	INS	-	-	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:6257784_6257785insT	uc001amd.3	-	1	90_91	c.44_45insA	c.(43-45)aagfs	p.K15fs	RPL22_uc001ame.3_Frame_Shift_Ins_p.K15fs	NM_000983	NP_000974	P35268	RL22_HUMAN	Homo sapiens ribosomal protein L22 (RPL22), mRNA.	15					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|RNA binding|structural constituent of ribosome	p.K15fs*5(2)		kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	Ovarian(185;0.0634)	all_cancers(23;2.78e-38)|all_epithelial(116;8.88e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.53e-38)|GBM - Glioblastoma multiforme(13;3.33e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.8e-19)|Colorectal(212;6.8e-08)|COAD - Colon adenocarcinoma(227;8.04e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		GAACTTGCTTCTTTTTTTTGCC	0.401			T	RUNX1	"""AML, CML"""							
ARHGEF10L	55160	broad.mit.edu	37	1	17990973	17990973	+	Silent	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:17990973C>T	uc001ban.3	+	25	3051	c.2892C>T	c.(2890-2892)ccC>ccT	p.P964P	ARHGEF10L_uc009vpe.1_Silent_p.P925P|ARHGEF10L_uc001bao.3_Silent_p.P925P|ARHGEF10L_uc001bap.3_Silent_p.P920P|ARHGEF10L_uc001baq.3_Silent_p.P725P|ARHGEF10L_uc010ocs.2_Silent_p.P737P|ARHGEF10L_uc001bar.3_Silent_p.P667P|ARHGEF10L_uc009vpf.3_Non-coding_Transcript	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Homo sapiens Rho guanine nucleotide exchange factor (GEF) 10-like (ARHGEF10L), transcript variant 1, mRNA.	964					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity	p.P964A(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		AGAGCCCTCCCGTGTGCCTGA	0.692												
NBPF10	100132406	broad.mit.edu	37	1	145311839	145311839	+	Missense_Mutation	SNP	A	A	T	rs58277049		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:145311839A>T	uc021oun.1	+	0					NBPF10_uc021ots.1_Intron|NBPF10_uc010oye.2_Intron|NBPF10_uc021oul.1_Intron|NBPF10_uc010oyi.2_Intron|NBPF10_uc010oyj.2_5'UTR|NBPF10_uc010oyl.2_5'UTR|NBPF10_uc021oum.1_Intron|NBPF10_uc021ouo.1_5'Flank			A6NDV3	A6NDV3_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 10 (NBPF10), mRNA.											NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CAGGACTCACAGGATAGATGT	0.473												
FLG	2312	broad.mit.edu	37	1	152276886	152276886	+	Silent	SNP	G	G	A	rs144901359		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:152276886G>A	uc001ezu.1	-	2	10512	c.10476C>T	c.(10474-10476)gaC>gaT	p.D3492D		NM_002016	NP_002007	P20930	FILA_HUMAN	Homo sapiens filaggrin (FLG), mRNA.	3492	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.D3492Y(1)		autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGATTGTTCGTCATTACGAG	0.567									Ichthyosis			
LCE2C	353140	broad.mit.edu	37	1	152648777	152648777	+	Missense_Mutation	SNP	C	C	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:152648777C>A	uc021ozc.1	+	0	286	c.286C>A	c.(286-288)Cct>Act	p.P96T	LCE2C_uc001fah.3_Missense_Mutation_p.P96T	NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	Homo sapiens late cornified envelope 2C (LCE2C), mRNA.	96	Cys-rich.				keratinization					endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)	13	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGAGTGAACCTTCTGGGGG	0.662												
NUP210L	91181	broad.mit.edu	37	1	154062058	154062058	+	Nonsense_Mutation	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:154062058G>A	uc001fdw.3	-	15	2272	c.2200C>T	c.(2200-2202)Cga>Tga	p.R734*	NUP210L_uc009woq.3_5'UTR|NUP210L_uc010peh.2_Nonsense_Mutation_p.R734*	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	Homo sapiens nucleoporin 210kDa-like (NUP210L), transcript variant 1, mRNA.	734						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TTTCCAATTCGGAATGTGAGA	0.423												
ARHGAP30	257106	broad.mit.edu	37	1	161023102	161023102	+	Missense_Mutation	SNP	C	C	T	rs149577194		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:161023102C>T	uc001fxl.3	-	5	956	c.610G>A	c.(610-612)Gtg>Atg	p.V204M	ARHGAP30_uc001fxk.3_Missense_Mutation_p.V204M|ARHGAP30_uc001fxm.3_Missense_Mutation_p.V50M|ARHGAP30_uc009wtx.3_5'UTR|ARHGAP30_uc001fxn.1_Missense_Mutation_p.V50M	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Homo sapiens Rho GTPase activating protein 30 (ARHGAP30), transcript variant 1, mRNA.	204	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			ATGAACTCCACGACGATGGAT	0.562												
NLRP3	114548	broad.mit.edu	37	1	247607348	247607348	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:247607348C>T	uc001icr.3	+	8	2882	c.2744C>T	c.(2743-2745)aCg>aTg	p.T915M	NLRP3_uc001ics.3_Missense_Mutation_p.T858M|NLRP3_uc001icu.3_Missense_Mutation_p.T915M|NLRP3_uc001icw.3_Missense_Mutation_p.T858M|NLRP3_uc001icv.3_Missense_Mutation_p.T801M|NLRP3_uc010pyw.2_Missense_Mutation_p.T893M	NM_001079821	NP_001230062	Q96P20	NALP3_HUMAN	Homo sapiens NLR family, pyrin domain containing 3 (NLRP3), transcript variant 3, mRNA.	915					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding	p.T915K(4)		NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CAGAATCTCACGCACCTTTAC	0.512												
PTEN	5728	broad.mit.edu	37	10	89720738	89720738	+	Frame_Shift_Del	DEL	G	G	-			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr10:89720738delG	uc001kfb.3	+	7	1921	c.889delG	c.(889-891)gatfs	p.D297fs	PTEN_uc021pvw.1_Non-coding_Transcript	NM_000314	NP_000305	P60484	PTEN_HUMAN	Homo sapiens phosphatase and tensin homolog (PTEN), mRNA.	297	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.R55fs*1(5)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.W274_F341del(2)|p.C296fs*1(1)|p.G165_*404del(1)|p.C296fs*11(1)|p.G165_K342del(1)|p.C296*(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AAGTCTATGTGATCAAGAAAT	0.318		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)		
OR8K3	219473	broad.mit.edu	37	11	56086620	56086620	+	Missense_Mutation	SNP	G	G	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr11:56086620G>T	uc010rjf.2	+	0	838	c.838G>T	c.(838-840)Gtt>Ttt	p.V280F		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	Homo sapiens olfactory receptor, family 8, subfamily K, member 3 (OR8K3), mRNA.	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					TTACACCCTGGTTATCCCCAT	0.378												
OR10W1	81341	broad.mit.edu	37	11	58034677	58034677	+	Missense_Mutation	SNP	C	C	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr11:58034677C>A	uc001nmq.1	-	0	1056	c.654G>T	c.(652-654)aaG>aaT	p.K218N		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily W, member 1 (OR10W1), mRNA.	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K218N(4)		kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				CCGAGTGGATCTTGAGCAGAG	0.572												
OR4D5	219875	broad.mit.edu	37	11	123811000	123811000	+	Missense_Mutation	SNP	G	G	A	rs142766960		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr11:123811000G>A	uc001pzk.1	+	0	677	c.677G>A	c.(676-678)cGa>cAa	p.R226Q		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily D, member 5 (OR4D5), mRNA.	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GTCATGCTCCGAAGCCACTCA	0.507												
LRIG3	121227	broad.mit.edu	37	12	59272793	59272793	+	Silent	SNP	G	G	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr12:59272793G>T	uc001sqr.3	-	13	2142	c.1896C>A	c.(1894-1896)ccC>ccA	p.P632P	LRIG3_uc009zqh.3_Silent_p.P572P|LRIG3_uc010ssh.2_Non-coding_Transcript	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	Homo sapiens leucine-rich repeats and immunoglobulin-like domains 3 (LRIG3), transcript variant 2, mRNA.	632	Ig-like C2-type 2.					integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			AGGCTATCTGGGGGGCTGGGT	0.597			T	ROS1	NSCLC							
NAV3	89795	broad.mit.edu	37	12	78582438	78582438	+	Missense_Mutation	SNP	A	A	C			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr12:78582438A>C	uc001syp.3	+	32	6109	c.5936A>C	c.(5935-5937)gAc>gCc	p.D1979A	NAV3_uc001syo.3_Missense_Mutation_p.D1957A|NAV3_uc010sub.2_Missense_Mutation_p.D1436A|NAV3_uc009zsf.3_Missense_Mutation_p.D788A	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	Homo sapiens neuron navigator 3 (NAV3), mRNA.	1979						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CTGAGCTCTGACTGCATTGCT	0.388										HNSCC(70;0.22)		
PLEKHG7	440107	broad.mit.edu	37	12	93148040	93148040	+	Missense_Mutation	SNP	C	C	T	rs115752910	by1000genomes	TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr12:93148040C>T	uc001tcj.2	+	6	720	c.490_splice	c.e6+1	p.R164_splice		NM_001004330	NP_001004330	Q6ZR37	PKHG7_HUMAN	Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 7 (PLEKHG7), mRNA.	164	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)	17						AAAGTCCATCCGTAAGTCCCT	0.438												
STAB2	55576	broad.mit.edu	37	12	104014256	104014256	+	Silent	SNP	T	T	G			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr12:104014256T>G	uc001tjw.3	+	3	528	c.342T>G	c.(340-342)ggT>ggG	p.G114G		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	Homo sapiens stabilin 2 (STAB2), mRNA.	114	EGF-like 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.G114C(1)		NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AGTGCCCAGGTGGAGCGGGGT	0.493												
GPR133	283383	broad.mit.edu	37	12	131622720	131622720	+	Silent	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr12:131622720G>A	uc010tbm.2	+	24	3130	c.2571G>A	c.(2569-2571)tcG>tcA	p.S857S	GPR133_uc001uit.4_Silent_p.S825S|GPR133_uc009zyo.3_Silent_p.S107S|GPR133_uc009zyp.3_Non-coding_Transcript	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	Homo sapiens G protein-coupled receptor 133 (GPR133), mRNA.	825					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		AGGTCTGGTCGCTCACGAGCA	0.597												
BIVM-ERCC5	2073	broad.mit.edu	37	13	103474461	103474462	+	Frame_Shift_Ins	INS	-	-	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr13:103474461_103474462insA	uc001vpu.2	+	4	975_976	c.853_854insA	c.(853-855)tatfs	p.Y285fs	BIVM-ERCC5_uc001vps.3_Frame_Shift_Ins_p.Y285fs|BIVM-ERCC5_uc010agc.3_Frame_Shift_Ins_p.Y56fs|BIVM-ERCC5_uc001vpv.3_Frame_Shift_Ins_p.Y56fs	NM_001204425	NP_001191354	Q59FZ7	Q59FZ7_HUMAN	Homo sapiens BIVM-ERCC5 readthrough (BIVM-ERCC5), mRNA.	256					nucleotide-excision repair	nucleus	endonuclease activity|single-stranded DNA binding										AGGATGCTCTTATGTTCTATAT	0.361												
FUT8	2530	broad.mit.edu	37	14	66028372	66028372	+	Nonsense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr14:66028372C>T	uc001xin.3	+	2	1818	c.91C>T	c.(91-93)Cga>Tga	p.R31*	FUT8_uc001xio.3_Nonsense_Mutation_p.R31*|FUT8_uc010tsp.2_Intron|FUT8_uc001xir.4_Non-coding_Transcript|FUT8_uc001xip.3_Nonsense_Mutation_p.R31*|FUT8_uc001xiq.3_Intron	NM_178155	NP_004471	Q9BYC5	FUT8_HUMAN	Homo sapiens fucosyltransferase 8 (alpha (1,6) fucosyltransferase) (FUT8), transcript variant 1, mRNA.	31					in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TCACTTGGTACGAGATAATGA	0.458												
AK7	122481	broad.mit.edu	37	14	96917806	96917806	+	Missense_Mutation	SNP	T	T	C			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr14:96917806T>C	uc001yfn.2	+	9	1041	c.997T>C	c.(997-999)Ttt>Ctt	p.F333L		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	Homo sapiens adenylate kinase 7 (AK7), mRNA.	333					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GGAAGCGCTCTTTGTGAAGGA	0.368												
GOLGA8C	729786	broad.mit.edu	37	15	20776109	20776109	+	Missense_Mutation	SNP	T	T	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr15:20776109T>A	uc010tzc.1	+	12	1620	c.605T>A	c.(604-606)cTg>cAg	p.L202Q	JA429730_uc021sfa.1_5'Flank					Homo sapiens golgin A8 family, member C (GOLGA8C), non-coding RNA.											haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(2)|ovary(1)|skin(1)	8						TAGGAGCGCCTGGAAGCTGCC	0.637												
CREBBP	1387	broad.mit.edu	37	16	3842056	3842056	+	Nonsense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr16:3842056C>T	uc002cvv.3	-	4	1460	c.1256G>A	c.(1255-1257)tGg>tAg	p.W419*	CREBBP_uc002cvw.3_Intron	NM_004380	NP_004371	Q92793	CBP_HUMAN	Homo sapiens CREB binding protein (CREBBP), transcript variant 1, mRNA.	419					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCAGTTCTTCCAATGAGAGAT	0.428			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome					
CIITA	4261	broad.mit.edu	37	16	11000852	11000852	+	Silent	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr16:11000852C>T	uc002daj.4	+	10	1639	c.1506C>T	c.(1504-1506)ttC>ttT	p.F502F	CIITA_uc002dai.4_Silent_p.F501F|CIITA_uc002dak.4_Intron|CIITA_uc002dag.2_Silent_p.F501F|CIITA_uc002dah.2_Silent_p.F453F|CIITA_uc010bup.1_Intron	NM_000246	NP_000237	P33076	C2TA_HUMAN	Homo sapiens class II, major histocompatibility complex, transactivator (CIITA), mRNA.	501	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						TAGACGGCTTCGAGGAGCTGG	0.647			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """							
PRKCB	5579	broad.mit.edu	37	16	24166139	24166139	+	Silent	SNP	G	G	A	rs141827066		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr16:24166139G>A	uc002dmd.3	+	9	1397	c.1200G>A	c.(1198-1200)ccG>ccA	p.P400P	PRKCB_uc002dme.3_Silent_p.P400P	NM_212535	NP_997700	P05771	KPCB_HUMAN	Homo sapiens protein kinase C, beta (PRKCB), transcript variant 1, mRNA.	400	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding	p.P400P(4)		central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	CTGGGAAGCCGCCCTTCCTGA	0.567												
LCMT1	51451	broad.mit.edu	37	16	25143735	25143735	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr16:25143735G>A	uc002dnx.1	+	2	376	c.218G>A	c.(217-219)cGa>cAa	p.R73Q	LCMT1_uc002dny.1_Missense_Mutation_p.R73Q	NM_016309	NP_057393	Q9UIC8	LCMT1_HUMAN	Homo sapiens leucine carboxyl methyltransferase 1 (LCMT1), transcript variant 1, mRNA.	73							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity								GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	TATTTTGCTCGAGTCCATGGT	0.488												
SLC6A10P	386757	broad.mit.edu	37	16	32890622	32890622	+	Missense_Mutation	SNP	T	T	G			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr16:32890622T>G	uc002edh.1	-	4	440	c.264A>C	c.(262-264)aaA>aaC	p.K88N	SLC6A10P_uc002edi.1_Non-coding_Transcript					Homo sapiens solute carrier family 6 (neurotransmitter transporter, creatine), member 10, pseudogene (SLC6A10P), non-coding RNA.																		CGTTGGTGTTTTTGTAGACCA	0.617												
MYH2	4620	broad.mit.edu	37	17	10427836	10427836	+	Missense_Mutation	SNP	C	C	T	rs147813930		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr17:10427836C>T	uc010coi.3	-	34	5250	c.5122G>A	c.(5122-5124)Gca>Aca	p.A1708T	AK097500_uc002gml.1_Intron|MYH2_uc002gmp.4_Missense_Mutation_p.A1708T|MYH2_uc010coj.3_Intron	NM_001100112	NP_060004	Q9UKX2	MYH2_HUMAN	Homo sapiens myosin, heavy chain 2, skeletal muscle, adult (MYH2), transcript variant 2, mRNA.	1708					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.I1707I(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TCCTGTTCTGCGATTTTTCTG	0.547												
KRT16	3868	broad.mit.edu	37	17	39767641	39767641	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr17:39767641C>T	uc002hxg.4	-	2	866	c.727G>A	c.(727-729)Ggc>Agc	p.G243S	JUP_uc010wfs.2_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	Homo sapiens keratin 16 (KRT16), mRNA.	243	Coil 1B.|Rod.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(137;0.000307)				TCCTTCAGGCCTTCGATCTGC	0.642												
KIF2B	84643	broad.mit.edu	37	17	51900949	51900949	+	Silent	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr17:51900949C>T	uc002iua.2	+	0	711	c.555C>T	c.(553-555)taC>taT	p.Y185Y	KIF2B_uc010wna.1_Non-coding_Transcript	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	Homo sapiens kinesin family member 2B (KIF2B), mRNA.	185					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						ACCCCAACTACGAAATCATGC	0.562												
ANKFN1	162282	broad.mit.edu	37	17	54452045	54452045	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr17:54452045G>A	uc002iun.1	+	6	924	c.889G>A	c.(889-891)Gtc>Atc	p.V297I		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	Homo sapiens ankyrin-repeat and fibronectin type III domain containing 1 (ANKFN1), mRNA.	297	Fibronectin type-III.									NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						GCCTCTTAGCGTCAATGCAGC	0.458												
CEP112	201134	broad.mit.edu	37	17	63848135	63848135	+	Silent	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr17:63848135C>T	uc002jfl.3	-	20	2400	c.2181G>A	c.(2179-2181)gaG>gaA	p.E727E	CEP112_uc010deo.3_Silent_p.E469E|CEP112_uc002jfm.3_Silent_p.E727E|CEP112_uc010dep.2_Silent_p.E685E	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	Homo sapiens centrosomal protein 112kDa (CEP112), transcript variant 1, mRNA.	727						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						GAACCTGGGCCTCCATGTCGG	0.418												
MC5R	4161	broad.mit.edu	37	18	13826256	13826256	+	Silent	SNP	C	C	T	rs45575841	byFrequency	TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr18:13826256C>T	uc010xaf.2	+	0	714	c.492C>T	c.(490-492)gcC>gcT	p.A164A		NM_005913	NP_005904	P33032	MC5R_HUMAN	Homo sapiens melanocortin 5 receptor (MC5R), mRNA.	164					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						CCATCATCGCCGGCATCTGGG	0.572												
CERS4	79603	broad.mit.edu	37	19	8320541	8320541	+	Silent	SNP	C	C	G			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr19:8320541C>G	uc002mjg.3	+	4	662	c.342C>G	c.(340-342)acC>acG	p.T114T	CERS4_uc002mji.3_5'UTR|CERS4_uc010dvz.3_Silent_p.T114T	NM_024552	NP_078828	Q9HA82	CERS4_HUMAN	Homo sapiens ceramide synthase 4 (CERS4), mRNA.	114						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										TGCAGCAGACCCAGCGATGGT	0.652												
CYP4F2	8529	broad.mit.edu	37	19	15990424	15990424	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr19:15990424G>A	uc002nbs.1	-	10	1354	c.1304C>T	c.(1303-1305)cCg>cTg	p.P435L	CYP4F2_uc010xot.1_Missense_Mutation_p.P286L	NM_001082	NP_001073	P78329	CP4F2_HUMAN	Homo sapiens cytochrome P450, family 4, subfamily F, polypeptide 2 (CYP4F2), mRNA.	435					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CTCAGGGTCCGGCCACACAGC	0.567												
TAF1B	9014	broad.mit.edu	37	2	9994457	9994457	+	Silent	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:9994457C>T	uc002qzz.3	+	4	406	c.306C>T	c.(304-306)aaC>aaT	p.N102N	TAF1B_uc010exc.2_Silent_p.N102N|TAF1B_uc002qzy.4_Silent_p.N102N|TAF1B_uc010yja.2_5'UTR|TAF1B_uc010exd.3_5'UTR	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	Homo sapiens TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa (TAF1B), mRNA.	102					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CACCTTAGAACGATGTTTTAC	0.408												
OTOF	9381	broad.mit.edu	37	2	26705441	26705441	+	Missense_Mutation	SNP	T	T	C			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:26705441T>C	uc002rhk.3	-	13	1539	c.1412A>G	c.(1411-1413)aAg>aGg	p.K471R		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	Homo sapiens otoferlin (OTOF), transcript variant 1, mRNA.	471	C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding	p.Q470*(1)		NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATAGCTGCTCTTCTGCACTGA	0.577												
BIRC6	57448	broad.mit.edu	37	2	32695356	32695356	+	Missense_Mutation	SNP	T	T	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:32695356T>A	uc010ezu.3	+	30	6602	c.6468T>A	c.(6466-6468)caT>caA	p.H2156Q		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	Homo sapiens baculoviral IAP repeat containing 6 (BIRC6), mRNA.	2156					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TACCCATGCATAGGAGGACAG	0.318												
TET3	200424	broad.mit.edu	37	2	74275488	74275489	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:74275488_74275489delAC	uc002skb.4	+	0	2039_2040	c.2039_2040delAC	c.(2038-2040)gacfs	p.D680fs	TET3_uc010fez.2_Frame_Shift_Del_p.D680fs	NM_144993	NP_659430	O43151	TET3_HUMAN	Homo sapiens tet methylcytosine dioxygenase 3 (TET3), mRNA.	680							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AGTCTGCTGGACACACCTGCCA	0.604												
POTEE	445582	broad.mit.edu	37	2	132021710	132021710	+	Silent	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:132021710C>T	uc002tsn.2	+	14	2734	c.2682C>T	c.(2680-2682)acC>acT	p.T894T	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Silent_p.T494T|POTEE_uc002tsl.2_Silent_p.T476T|POTEE_uc010fmy.1_Silent_p.T358T	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	Homo sapiens POTE ankyrin domain family, member E (POTEE), mRNA.	894	Actin-like.						ATP binding										AGATCCTCACCGAGCGTGGCT	0.587												
LOC401010	401010	broad.mit.edu	37	2	132201557	132201557	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:132201557C>T	uc002tst.2	-	0	911	c.445G>A	c.(445-447)Gta>Ata	p.V149I						Homo sapiens nucleolar complex associated 2 homolog (S. cerevisiae) pseudogene (LOC401010), non-coding RNA.																		GTGCTCCATACGACCACCATT	0.602												
MYO1B	4430	broad.mit.edu	37	2	192275792	192275792	+	Missense_Mutation	SNP	T	T	C			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:192275792T>C	uc010fsg.2	+	27	3022	c.2767_splice	c.e27-1	p.C923_splice	MYO1B_uc002usq.2_Splice_Site_p.C865_splice|MYO1B_uc002usr.2_Splice_Site_p.C923_splice|MYO1B_uc002usu.2_Splice_Site_p.C168_splice	NM_001130158	NP_001155291	O43795	MYO1B_HUMAN	Homo sapiens myosin IB (MYO1B), transcript variant 1, mRNA.	923						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			TATCTCACAGTGTAAAAAATA	0.308												
MATN4	8785	broad.mit.edu	37	20	43929967	43929967	+	Missense_Mutation	SNP	A	A	G			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr20:43929967A>G	uc002xnn.2	-	3	947	c.760T>C	c.(760-762)Tgc>Cgc	p.C254R	MATN4_uc002xnp.2_Intron|MATN4_uc002xno.2_Intron|MATN4_uc010zwr.1_Missense_Mutation_p.C202R|MATN4_uc002xnr.1_Missense_Mutation_p.C254R	NM_003833	NP_003824	O95460	MATN4_HUMAN	Homo sapiens matrilin 4 (MATN4), transcript variant 1, mRNA.	295	EGF-like 1; incomplete.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				TCACCCCTGCAGCTCCTCTGG	0.587											OREG0025977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
OPRL1	4987	broad.mit.edu	37	20	62724089	62724089	+	Missense_Mutation	SNP	C	C	T	rs148535906		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr20:62724089C>T	uc002yic.3	+	2	435	c.16C>T	c.(16-18)Ccc>Tcc	p.P6S	OPRL1_uc002yid.3_Missense_Mutation_p.P6S|OPRL1_uc021wgs.1_Missense_Mutation_p.P6S|OPRL1_uc002yif.4_Missense_Mutation_p.P6S	NM_182647	NP_872588	P41146	OPRX_HUMAN	Homo sapiens opiate receptor-like 1 (OPRL1), transcript variant 1, mRNA.	6					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GCCCCTCTTCCCCGCGCCGTT	0.632												
KCNJ15	3772	broad.mit.edu	37	21	39671533	39671533	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr21:39671533C>T	uc021wjc.1	+	0	350	c.350C>T	c.(349-351)gCg>gTg	p.A117V	KCNJ15_uc002ywv.3_Missense_Mutation_p.A117V|KCNJ15_uc002yww.3_Missense_Mutation_p.A117V|KCNJ15_uc002ywx.3_Missense_Mutation_p.A117V	NM_170737	NP_733933	Q99712	IRK15_HUMAN	Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 15 (KCNJ15), transcript variant 3, mRNA.	117					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						CTCACTGGGGCGTTTCTCTTT	0.493												
UMODL1	89766	broad.mit.edu	37	21	43522316	43522316	+	Missense_Mutation	SNP	C	C	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr21:43522316C>A	uc002zag.1	+	7	1227	c.1227C>A	c.(1225-1227)caC>caA	p.H409Q	UMODL1_uc002zad.1_Missense_Mutation_p.H337Q|UMODL1_uc002zae.1_Missense_Mutation_p.H337Q|UMODL1_uc002zaf.1_Missense_Mutation_p.H409Q|UMODL1_uc010gow.1_Missense_Mutation_p.H201Q|UMODL1_uc002zai.1_Missense_Mutation_p.H60Q|UMODL1_uc010gox.1_Non-coding_Transcript|UMODL1_uc010goy.1_Missense_Mutation_p.H60Q|UMODL1_uc002zaj.1_Non-coding_Transcript|UMODL1_uc010goz.1_Missense_Mutation_p.H154Q|C21orf128_uc002zak.2_3'UTR	NM_173568	NP_001186456	Q5DID0	UROL1_HUMAN	Homo sapiens uromodulin-like 1 (UMODL1), transcript variant 2, mRNA.	409	SEA 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						TTGTAAACCACAACCTGACGG	0.428												
FGD5	152273	broad.mit.edu	37	3	14862751	14862751	+	Missense_Mutation	SNP	T	T	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr3:14862751T>A	uc003bzc.3	+	0	2283	c.2173T>A	c.(2173-2175)Tat>Aat	p.Y725N	FGD5_uc011avk.2_Missense_Mutation_p.Y725N	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	Homo sapiens FYVE, RhoGEF and PH domain containing 5 (FGD5), mRNA.	725					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						CCTCATCTTTTATAGAGATGG	0.577												
DAG1	1605	broad.mit.edu	37	3	49568839	49568839	+	Missense_Mutation	SNP	A	A	G			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr3:49568839A>G	uc021wxz.1	+	2	1364	c.895A>G	c.(895-897)Atc>Gtc	p.I299V	DAG1_uc021wya.1_Missense_Mutation_p.I299V|DAG1_uc021wyb.1_Missense_Mutation_p.I299V|DAG1_uc021wyc.1_Missense_Mutation_p.I299V|DAG1_uc021wyd.1_Missense_Mutation_p.I299V|DAG1_uc021wye.1_Missense_Mutation_p.I299V|DAG1_uc021wyf.1_Missense_Mutation_p.I299V|DAG1_uc021wyg.1_Missense_Mutation_p.I299V|DAG1_uc021wyh.1_Missense_Mutation_p.I299V|DAG1_uc021wyi.1_Missense_Mutation_p.I299V|DAG1_uc021wyj.1_Missense_Mutation_p.I299V|DAG1_uc021wyk.1_Missense_Mutation_p.I299V|DAG1_uc003cxc.4_Missense_Mutation_p.I299V	NM_001177643	NP_001171114	Q14118	DAG1_HUMAN	Homo sapiens dystroglycan 1 (dystrophin-associated glycoprotein 1) (DAG1), transcript variant 12, mRNA.	299	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GGGTTGGCACATCGCCAATAA	0.597												
CASR	846	broad.mit.edu	37	3	121980530	121980530	+	Silent	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr3:121980530C>T	uc003eew.4	+	3	1086	c.648C>T	c.(646-648)gaC>gaT	p.D216D	CASR_uc003eev.4_Silent_p.D216D	NM_001178065	NP_001171536	P41180	CASR_HUMAN	Homo sapiens calcium-sensing receptor (CASR), transcript variant 1, mRNA.	216					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity	p.D216D(2)		NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CAGCTGATGACGACTATGGGC	0.537												
ADCY5	111	broad.mit.edu	37	3	123038564	123038564	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr3:123038564C>T	uc003egh.2	-	9	2213	c.2213G>A	c.(2212-2214)cGc>cAc	p.R738H	ADCY5_uc021xdd.1_Missense_Mutation_p.R388H|ADCY5_uc003egg.2_Missense_Mutation_p.R371H|ADCY5_uc003egi.1_Missense_Mutation_p.R297H	NM_183357	NP_899200	O95622	ADCY5_HUMAN	Homo sapiens adenylate cyclase 5 (ADCY5), transcript variant 1, mRNA.	738					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		GAGGAACTTGCGGACGTGCTC	0.587												
PIGZ	80235	broad.mit.edu	37	3	196675037	196675037	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr3:196675037C>T	uc003fxh.3	-	2	878	c.731G>A	c.(730-732)cGt>cAt	p.R244H		NM_025163	NP_079439	Q86VD9	PIGZ_HUMAN	Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class Z (PIGZ), mRNA.	244					GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			breast(1)|endometrium(1)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	14	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		TGTGGCTCCACGAGTGCCCCA	0.637												
ZNF718	255403	broad.mit.edu	37	4	155414	155414	+	Silent	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr4:155414C>T	uc003fzw.4	+	1	867	c.278C>T	c.(277-279)gCg>gTg	p.A93V	ZNF718_uc003fzt.4_Silent_p.C313C|ZNF718_uc003fzu.1_Intron|ZNF718_uc010iaz.3_Non-coding_Transcript	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	Homo sapiens zinc finger protein 718 (ZNF718), mRNA.	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		CCTTCTCATGCGAAGAATGTG	0.373												
RBM47	54502	broad.mit.edu	37	4	40440359	40440359	+	Silent	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr4:40440359G>A	uc003gvc.2	-	3	1262	c.552C>T	c.(550-552)taC>taT	p.Y184Y	RBM47_uc003gvd.2_Silent_p.Y184Y|RBM47_uc003gve.2_Non-coding_Transcript|RBM47_uc011bys.1_Silent_p.Y146Y|RBM47_uc003gvg.1_Silent_p.Y184Y	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	Homo sapiens RNA binding motif protein 47 (RBM47), transcript variant 1, mRNA.	184	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CCGCGCTGGCGTAGACGATCA	0.647												
ALB	213	broad.mit.edu	37	4	74283995	74283995	+	Missense_Mutation	SNP	T	T	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr4:74283995T>A	uc003hgs.4	+	11	1692	c.1619T>A	c.(1618-1620)cTt>cAt	p.L540H	ALB_uc011cbe.2_Missense_Mutation_p.L219H|ALB_uc003hgw.4_Missense_Mutation_p.L348H|ALB_uc011cbf.2_Missense_Mutation_p.L430H	NM_000477	NP_000468	P02768	ALBU_HUMAN	Homo sapiens albumin (ALB), mRNA.	540	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	ATATGCACACTTTCTGAGAAG	0.403												
PPEF2	5470	broad.mit.edu	37	4	76793227	76793227	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr4:76793227C>T	uc003hix.3	-	12	1957	c.1600G>A	c.(1600-1602)Gtg>Atg	p.V534M	PPEF2_uc003hiy.3_Non-coding_Transcript|PPEF2_uc003hiz.1_Missense_Mutation_p.V534M	NM_006239	NP_006230	O14830	PPE2_HUMAN	Homo sapiens protein phosphatase, EF-hand calcium binding domain 2 (PPEF2), mRNA.	534	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TGATACTGCACAATATGTGGG	0.428												
ADAMTS12	81792	broad.mit.edu	37	5	33596125	33596125	+	Silent	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr5:33596125G>A	uc003jia.1	-	16	2731	c.2568C>T	c.(2566-2568)cgC>cgT	p.R856R	ADAMTS12_uc010iuq.1_Silent_p.R771R	NM_030955	NP_112217	P58397	ATS12_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 12 (ADAMTS12), mRNA.	856	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TCACCATCCCGCGGCCCTTCT	0.512										HNSCC(64;0.19)		
PCDHAC2	56139	broad.mit.edu	37	5	140237259	140237259	+	Silent	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr5:140237259G>A	uc003lhx.2	+	0	1626	c.1626G>A	c.(1624-1626)ccG>ccA	p.P542P	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc003lhf.2_Intron|PCDHAC2_uc003lhh.1_Intron|PCDHAC2_uc003lhi.2_Intron|PCDHAC2_uc003lhl.2_Intron|PCDHAC2_uc003lhk.1_Intron|PCDHAC2_uc003lho.2_Intron|PCDHAC2_uc003lhn.2_Intron|PCDHAC2_uc003lhq.2_Intron|PCDHAC2_uc003lhs.2_Intron|PCDHAC2_uc003lhu.2_Intron|PCDHAC2_uc003lhw.2_Intron|PCDHAC2_uc011dad.2_Silent_p.P542P	NM_018901	NP_061724	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 10 (PCDHA10), transcript variant 1, mRNA.	557	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGGCGTGCCGCCTCTGGGCA	0.697												
PCDHB5	26167	broad.mit.edu	37	5	140517047	140517052	+	In_Frame_Del	DEL	GGCCCA	GGCCCA	-			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr5:140517047_140517052delGGCCCA	uc003liq.3	+	0	2248_2253	c.2031_2036delGGCCCA	c.(2029-2037)ccggcccag>ccg	p.AQ680del		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	Homo sapiens protocadherin beta 5 (PCDHB5), mRNA.	680					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGCGGCCCCGGCCCAGGCCCAGGCC	0.694												
RIPK1	8737	broad.mit.edu	37	6	3104537	3104537	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr6:3104537C>T	uc010jni.3	+	7	1226	c.994C>T	c.(994-996)Cgg>Tgg	p.R332W	RIPK1_uc003muv.4_Missense_Mutation_p.R169W|RIPK1_uc003mux.3_Missense_Mutation_p.R332W|RIPK1_uc011dhs.2_Missense_Mutation_p.R286W	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	Homo sapiens receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), mRNA.	332	Interaction with SQSTM1.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				ACCTTCAAGCCGGTCAAATTC	0.348												
OR2H1	26716	broad.mit.edu	37	6	29430405	29430405	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr6:29430405G>A	uc003nmi.3	+	2	1302	c.859G>A	c.(859-861)Gta>Ata	p.V287I	OR2H1_uc003nmj.1_Missense_Mutation_p.V287I|OR2H1_uc010jri.2_Missense_Mutation_p.V209I|OR2H1_uc021ytr.1_Missense_Mutation_p.V287I	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily H, member 1 (OR2H1), mRNA.	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						TAACCCTCTCGTATACACCCT	0.493												
GABBR1	2550	broad.mit.edu	37	6	29599228	29599228	+	Silent	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr6:29599228G>A	uc003nmt.4	-	2	570	c.234C>T	c.(232-234)gtC>gtT	p.V78V	GABBR1_uc003nmu.4_Silent_p.V78V|GABBR1_uc011dlr.2_5'UTR|GABBR1_uc011dls.1_Silent_p.V78V	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript variant 1, mRNA.	78	Sushi 1.				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	GGCACTTGCGGACCTTGGGCC	0.602												
HLA-DQB2	3120	broad.mit.edu	37	6	32729588	32729588	+	Silent	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr6:32729588G>A	uc003obz.2	-	1	296	c.213C>T	c.(211-213)gaC>gaT	p.D71D	HLA-DQB2_uc003oby.4_Silent_p.D71D	NM_001198858	NP_001185787	Q5SR06	Q5SR06_HUMAN	Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), mRNA.	71					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex		p.S70S(1)		endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						ACTCCCCAACGTCGCTGTCGA	0.607												
TNRC18	84629	broad.mit.edu	37	7	5417608	5417608	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:5417608G>A	uc003soi.4	-	5	2549	c.2200C>T	c.(2200-2202)Cgg>Tgg	p.R734W		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	Homo sapiens trinucleotide repeat containing 18 (TNRC18), mRNA.	734							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CGTTCCTCCCGGTGTCTGGCC	0.682												
RAMP3	10268	broad.mit.edu	37	7	45216987	45216987	+	Silent	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:45216987C>T	uc003tnb.3	+	1	199	c.138C>T	c.(136-138)gaC>gaT	p.D46D		NM_005856	NP_005847	O60896	RAMP3_HUMAN	Homo sapiens receptor (G protein-coupled) activity modifying protein 3 (RAMP3), mRNA.	46					intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane|lysosome	protein transporter activity			breast(1)|endometrium(1)|large_intestine(4)|lung(4)|stomach(1)	11					Pramlintide(DB01278)	CTTTCGCAGACATGATGGGCA	0.607												
EGFR	1956	broad.mit.edu	37	7	55221821	55221821	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:55221821G>A	uc003tqk.3	+	6	1111	c.865G>A	c.(865-867)Gcc>Acc	p.A289T	EGFR_uc003tqh.3_Missense_Mutation_p.A289T|EGFR_uc003tqi.3_Missense_Mutation_p.A289T|EGFR_uc003tqj.3_Missense_Mutation_p.A289T|EGFR_uc022adm.1_Missense_Mutation_p.A289T|EGFR_uc010kzg.2_Missense_Mutation_p.A244T|EGFR_uc022adn.1_Missense_Mutation_p.A244T|EGFR_uc011kco.2_Missense_Mutation_p.A236T|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.	289					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.A289T(6)|p.V30_R297>G(5)|p.A289D(3)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGCTTTGGTGCCACCTGCGT	0.592		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)		
EGFR	1956	broad.mit.edu	37	7	55249022	55249022	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:55249022G>A	uc003tqk.3	+	19	2566	c.2320G>A	c.(2320-2322)Gtg>Atg	p.V774M	EGFR_uc022adm.1_Missense_Mutation_p.V774M|EGFR_uc010kzg.2_Missense_Mutation_p.V729M|EGFR_uc022adn.1_Missense_Mutation_p.V729M|EGFR_uc011kco.2_Missense_Mutation_p.V721M|AK123474_uc003tqo.3_Non-coding_Transcript|EGFR_uc022ado.1_Missense_Mutation_p.V9M	NM_005228	NP_005219	P00533	EGFR_HUMAN	Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.	774	Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.H773_V774insNPH(21)|p.P772_H773insPR(11)|p.V774M(9)|p.H773R(9)|p.H773_V774insH(5)|p.H773_V774insPH(4)|p.V774_C775insHV(4)|p.H773_V774insQ(2)|p.P772_H773insYNP(2)|p.H773_V774insGNPH(2)|p.P772_H773insX(2)|p.H773L(2)|p.V774L(2)|p.H773Y(2)|p.H773_V774insGH(1)|p.H773_V774insG(1)|p.P772_H773insV(1)|p.V774del(1)|p.P772_H773insDHP(1)|p.P772_H773insTHP(1)|p.P772_H773insDNP(1)|p.P772_H773insHV(1)|p.H773>NPY(1)|p.P772_H773insQV(1)|p.H773_V774>LM(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAACCCCCACGTGTGCCGCCT	0.632		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)		
PCLO	27445	broad.mit.edu	37	7	82582186	82582186	+	Frame_Shift_Del	DEL	A	A	-			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:82582186delA	uc003uhx.2	-	4	8372	c.8083delT	c.(8083-8085)tccfs	p.S2695fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.S2695fs|PCLO_uc010lec.3_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	Homo sapiens piccolo (presynaptic cytomatrix protein) (PCLO), transcript variant 1, mRNA.	2626					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ATTGTTATGGAAATGCTGCTG	0.413												
BAIAP2L1	55971	broad.mit.edu	37	7	97935824	97935824	+	Missense_Mutation	SNP	C	C	G			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:97935824C>G	uc003upj.3	-	10	1431	c.1168G>C	c.(1168-1170)Ggt>Cgt	p.G390R	hCG_2023280_uc003upk.1_5'Flank	NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	Homo sapiens BAI1-associated protein 2-like 1 (BAIAP2L1), mRNA.	390	SH3.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)	23	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			GGGAACCAACCCCTCCTACCG	0.572												
MCM7	4176	broad.mit.edu	37	7	99694927	99694927	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:99694927G>A	uc003usw.1	-	9	1708	c.1198C>T	c.(1198-1200)Cgc>Tgc	p.R400C	MCM7_uc003usv.1_Missense_Mutation_p.R224C|MCM7_uc003usx.1_Missense_Mutation_p.R224C	NM_005916	NP_005907	P33993	MCM7_HUMAN	Homo sapiens minichromosome maintenance complex component 7 (MCM7), transcript variant 1, mRNA.	400	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding	p.R400C(1)|p.R224C(1)		endometrium(1)|kidney(5)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	TACTTACTGCGAGGCGCCAGT	0.512												
ASZ1	136991	broad.mit.edu	37	7	117020042	117020042	+	Silent	SNP	T	T	C			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:117020042T>C	uc003vjb.2	-	9	1068	c.1005A>G	c.(1003-1005)gtA>gtG	p.V335V	ASZ1_uc011kno.1_Silent_p.V335V|ASZ1_uc011knp.1_Silent_p.V127V	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	Homo sapiens ankyrin repeat, SAM and basic leucine zipper domain containing 1 (ASZ1), transcript variant 1, mRNA.	335					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			GTATCTCTTCTACCTGTAGTT	0.308												
HIPK2	28996	broad.mit.edu	37	7	139416214	139416214	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:139416214C>T	uc003vvf.4	-	1	891	c.620G>A	c.(619-621)cGa>cAa	p.R207Q	HIPK2_uc003vvd.4_Missense_Mutation_p.R207Q	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	Homo sapiens homeodomain interacting protein kinase 2 (HIPK2), transcript variant 1, mRNA.	207	Interaction with DAXX.|Protein kinase.|Transcriptional corepression (By similarity).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					AAACGTCCCTCGGCCCAAGAA	0.552												
CLCN1	1180	broad.mit.edu	37	7	143048733	143048733	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:143048733G>A	uc003wcr.1	+	22	2729	c.2642G>A	c.(2641-2643)cGc>cAc	p.R881H	CLCN1_uc011ktc.1_Missense_Mutation_p.R493H	NM_000083	NP_000074	P35523	CLCN1_HUMAN	Homo sapiens chloride channel 1, skeletal muscle (CLCN1), mRNA.	881					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity	p.L880L(1)		breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GTGCAGCTCCGCCCTCCCCTT	0.537												
KCNB2	9312	broad.mit.edu	37	8	73848914	73848914	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr8:73848914C>T	uc003xzb.3	+	2	1912	c.1324C>T	c.(1324-1326)Cgg>Tgg	p.R442W		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	Homo sapiens potassium voltage-gated channel, Shab-related subfamily, member 2 (KCNB2), mRNA.	442					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GGCTCTTGAGCGGGCCAAAAG	0.443												
KIFC2	90990	broad.mit.edu	37	8	145693119	145693119	+	Missense_Mutation	SNP	T	T	C			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr8:145693119T>C	uc003zcz.3	+	5	703	c.638T>C	c.(637-639)cTg>cCg	p.L213P	CYHR1_uc003zcv.2_5'Flank|CYHR1_uc003zcw.2_5'Flank|CYHR1_uc003zcx.2_5'Flank|CYHR1_uc003zcy.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	Homo sapiens kinesin family member C2 (KIFC2), mRNA.	213	Gln-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(3)|prostate(3)|skin(2)|urinary_tract(1)	19	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			AAGCAGCAGCTGGAACAGCAG	0.642											OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
BNC2	54796	broad.mit.edu	37	9	16419304	16419304	+	Missense_Mutation	SNP	C	C	T	rs143124811	byFrequency	TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr9:16419304C>T	uc003zml.3	-	6	3123	c.2983G>A	c.(2983-2985)Ggg>Agg	p.G995R	BNC2_uc011lmw.2_Missense_Mutation_p.G900R|BNC2_uc003zmm.3_3'UTR|BNC2_uc011lmv.2_3'UTR|BNC2_uc003zmj.3_3'UTR|BNC2_uc003zmk.3_Non-coding_Transcript|BNC2_uc003zmi.3_Missense_Mutation_p.G782R	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	Homo sapiens basonuclin 2 (BNC2), mRNA.	995					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		TCACTCGCCCCGTCAATGTCA	0.592												
TAF1L	138474	broad.mit.edu	37	9	32631824	32631824	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr9:32631824G>A	uc003zrg.1	-	0	3844	c.3754C>T	c.(3754-3756)Cgg>Tgg	p.R1252W	AX747113_uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	Homo sapiens TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like (TAF1L), mRNA.	1252					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding	p.R1252W(2)		breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CGCTTAAGCCGCCTCAGTTGC	0.448												
STAG2	10735	broad.mit.edu	37	X	123205046	123205047	+	Frame_Shift_Del	DEL	TA	TA	-			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chrX:123205046_123205047delTA	uc004eua.3	+	24	2810_2811	c.2406_2407delTA	c.(2404-2409)attatgfs	p.I802fs	STAG2_uc004etz.4_Frame_Shift_Del_p.I802fs|STAG2_uc004eub.3_Frame_Shift_Del_p.I802fs|STAG2_uc004euc.3_Frame_Shift_Del_p.I802fs|STAG2_uc004eud.3_Frame_Shift_Del_p.I802fs|STAG2_uc004eue.3_Frame_Shift_Del_p.I802fs	NM_001042749	NP_001036215	Q8N3U4	STAG2_HUMAN	Homo sapiens stromal antigen 2 (STAG2), transcript variant 1, mRNA.	802					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding	p.Q801*(1)		breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						GCCATCAGATTATGTCAGGAGG	0.376												
