Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NLRP7	199713	broad.mit.edu	37	19	55451248	55451248	+	Silent	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr19:55451248C>T	ENST00000588756.1	-	6	1425	c.939G>A	c.(937-939)gcG>gcA	p.A313A	NLRP7_ENST00000592784.1_Silent_p.A313A|NLRP7_ENST00000590030.1_Silent_p.A313A|NLRP7_ENST00000340844.2_Silent_p.A313A|NLRP7_ENST00000328092.5_Silent_p.A313A|NLRP7_ENST00000448121.2_Silent_p.A313A|NLRP7_ENST00000446217.1_Silent_p.A341A			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	313	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TCGGCTGCTGCGCCAGGAGCT	0.622000													6	28					0	0	1	0	0
LTV1	84946	broad.mit.edu	37	6	144167303	144167303	+	Nonsense_Mutation	SNP	C	C	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr6:144167303C>A	ENST00000367576.5	+	3	385	c.251C>A	c.(250-252)tCa>tAa	p.S84*		NM_032860.3	NP_116249.2	Q96GA3	LTV1_HUMAN	LTV1 homolog (S. cerevisiae)	84										breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)	13				OV - Ovarian serous cystadenocarcinoma(155;2.72e-06)|GBM - Glioblastoma multiforme(68;0.0372)		CTTATTCCCTCAAGTACCTTC	0.463000													4	32					0.150653	0.150653	1	1	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													3	51					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152326021	152326021	+	Missense_Mutation	SNP	G	G	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr1:152326021G>T	ENST00000388718.5	-	3	4313	c.4241C>A	c.(4240-4242)tCc>tAc	p.S1414Y	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1414							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTTGTCCTGGACCCTCTCTG	0.512000													49	215					9.22156e-22	9.89961e-22	1	1	0
SLC13A2	9058	broad.mit.edu	37	17	26816242	26816242	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr17:26816242G>A	ENST00000444914.3	+	2	533	c.113G>A	c.(112-114)tGc>tAc	p.C38Y	SLC13A2_ENST00000545060.1_Intron|SLC13A2_ENST00000537681.1_5'UTR|SLC13A2_ENST00000314669.5_Missense_Mutation_p.C38Y	NM_001145975.1	NP_001139447.1	Q13183	S13A2_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	38						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	GAGGCCTACTGCGCGTATGCC	0.602000													12	37					0	0	1	0	0
TRAV26-1	0	broad.mit.edu	37	14	22592243	22592243	+	RNA	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr14:22592243G>A	ENST00000390455.3	+	0	537																											CGTCAGAGTCGCACACTGGGA	0.532000													7	18					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303923	151303923	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chrX:151303923G>A	ENST00000370323.4	-	4	486	c.170C>T	c.(169-171)tCt>tTt	p.S57F	MAGEA10_ENST00000244096.3_Missense_Mutation_p.S57F|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	57	Poly-Ser.									endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					ggaggaggaagaggaggagga	0.562000													18	23					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79318298	79318298	+	Missense_Mutation	SNP	T	T	C			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr9:79318298T>C	ENST00000428286.1	-	9	8354	c.7154A>G	c.(7153-7155)gAg>gGg	p.E2385G	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E2744G			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2744					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GAACTCTGTCTCCTCCTCCAT	0.423000													3	35					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209788707	209788707	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr1:209788707C>T	ENST00000391911.1	-	22	3817	c.3428G>A	c.(3427-3429)cGc>cAc	p.R1143H	LAMB3_ENST00000356082.4_Missense_Mutation_p.R1143H|LAMB3_ENST00000367030.3_Missense_Mutation_p.R1143H	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	1143	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GTCCGCTGAGCGCAGCATGAT	0.587000													13	44					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133602453	133602453	+	Silent	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr7:133602453G>A	ENST00000253861.4	+	13	2018	c.1989G>A	c.(1987-1989)caG>caA	p.Q663Q	EXOC4_ENST00000460346.1_3'UTR|EXOC4_ENST00000545148.1_Silent_p.Q273Q|EXOC4_ENST00000539845.1_Silent_p.Q562Q	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	663					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				AACCCAAACAGCTGAGGCCAA	0.398000													17	86					0	0	1	0	0
RANBP17	64901	broad.mit.edu	37	5	170345766	170345766	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr5:170345766G>A	ENST00000523189.1	+	10	1168	c.1004G>A	c.(1003-1005)cGt>cAt	p.R335H		NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	335					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTTTTGGCTCGTTTAAAGACA	0.338000			T	TRD@	ALL								9	39					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77661986	77661986	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr4:77661986G>A	ENST00000296043.6	+	5	3613	c.2660G>A	c.(2659-2661)cGt>cAt	p.R887H		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	887					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			CGGCTCCTCCGTAGCCAGAGC	0.711000													5	15					0	0	1	0	0
VCX3A	51481	broad.mit.edu	37	X	6451822	6451822	+	Missense_Mutation	SNP	A	A	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chrX:6451822A>T	ENST00000381089.3	-	3	831	c.525T>A	c.(523-525)agT>agA	p.S175R	VCX3A_ENST00000398729.1_Missense_Mutation_p.S155R	NM_016379.3	NP_057463.2	Q9NNX9	VCX3_HUMAN	variable charge, X-linked 3A	175	8 X 10 AA tandem repeats of L-S-Q-E-S- [EQ]-V-E-E-P.|Glu-rich.				brain development	nucleolus				NS(1)|lung(2)|pancreas(1)	4						CGCTCTCCTGACTCAGTGGTT	0.587000													26	77					0	0	1	0	0
PCDHA7	0	broad.mit.edu	37	5	140215578	140215578	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr5:140215578C>T	ENST00000525929.1	+	1	1610	c.1610C>T	c.(1609-1611)gCg>gTg	p.A537V	PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.A537V|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGTGAGCGCGCGCGATGCG	0.677000													38	130					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102278	22102278	+	Missense_Mutation	SNP	G	G	A	rs137944778		TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr14:22102278G>A	ENST00000542433.1	-	1	818	c.721C>T	c.(721-723)Cgg>Tgg	p.R241W		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		GAGAAGGCCCGGCGCCTCCCA	0.552000													4	32					0	0	1	0	0
ZNRF1	84937	broad.mit.edu	37	16	75127493	75127493	+	Missense_Mutation	SNP	A	A	G			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr16:75127493A>G	ENST00000335325.4	+	2	1090	c.448A>G	c.(448-450)Aag>Gag	p.K150E	ZNRF1_ENST00000320619.6_Missense_Mutation_p.K150E|ZNRF1_ENST00000566250.1_Missense_Mutation_p.K150E|ZNRF1_ENST00000564320.1_3'UTR|ZNRF1_ENST00000567962.1_Missense_Mutation_p.K150E	NM_032268.4	NP_115644.1	Q8ND25	ZNRF1_HUMAN	zinc and ring finger 1, E3 ubiquitin protein ligase	150						cell junction|endosome|lysosome|synaptic vesicle membrane	ligase activity|protein binding|zinc ion binding			breast(1)	1						CATTTGCTCCAAGTCTGTGGC	0.483000													21	60					0	0	1	0	0
DDX46	9879	broad.mit.edu	37	5	134102743	134102743	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr5:134102743G>A	ENST00000452510.2	+	3	501	c.343G>A	c.(343-345)Gag>Aag	p.E115K	DDX46_ENST00000354283.4_Missense_Mutation_p.E115K	NM_014829.2	NP_055644.2	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	115					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CAAGAAAACTGAGAATAGGTA	0.468000													3	35					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40900052	40900052	+	Missense_Mutation	SNP	C	C	T	rs139051512		TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr19:40900052C>T	ENST00000324001.7	-	7	4477	c.4207G>A	c.(4207-4209)Gtc>Atc	p.V1403I	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	1403					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding	p.V1403I(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TTCTCTCTGACGGGGGACTTG	0.692000													14	74					0	0	1	0	0
PITRM1	10531	broad.mit.edu	37	10	3189439	3189439	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr10:3189439G>A	ENST00000380989.2	-	20	2280	c.2242C>T	c.(2242-2244)Cgg>Tgg	p.R748W	PITRM1-AS1_ENST00000598280.1_RNA|PITRM1_ENST00000380994.1_Missense_Mutation_p.R305W|PITRM1_ENST00000464395.1_5'UTR|PITRM1_ENST00000451104.2_Missense_Mutation_p.R649W|PITRM1-AS1_ENST00000601046.1_RNA|PITRM1_ENST00000224949.4_Missense_Mutation_p.R747W	NM_001242307.1|NM_014889.3	NP_001229236.1|NP_055704.2	E7ES23	E7ES23_HUMAN	pitrilysin metallopeptidase 1	649					proteolysis		metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|urinary_tract(3)	33						TTCATCAGCCGCACCTAAGCC	0.498000													3	40					0	0	1	0	0
G6PC	2538	broad.mit.edu	37	17	41063169	41063169	+	Missense_Mutation	SNP	C	C	T	rs145296477	byFrequency	TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr17:41063169C>T	ENST00000253801.2	+	5	879	c.800C>T	c.(799-801)aCg>aTg	p.T267M	G6PC_ENST00000585489.1_3'UTR|G6PC_ENST00000592383.1_3'UTR	NM_000151.3	NP_000142.2	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	267					gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		AACCTGGGCACGCTCTTTGGC	0.582000													6	34					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22923871	22923871	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr1:22923871C>T	ENST00000166244.3	+	10	1904	c.1832C>T	c.(1831-1833)gCg>gTg	p.A611V		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	611						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CAGTTCTATGCGGAACCCCAC	0.652000													21	120					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603696	138603696	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr7:138603696C>T	ENST00000440172.1	-	2	724	c.676G>A	c.(676-678)Gcc>Acc	p.A226T	KIAA1549_ENST00000422774.1_Missense_Mutation_p.A226T|KIAA1549_ENST00000242365.4_Missense_Mutation_p.A176T	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	226						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						AAATGACTGGCGGACTCAGCA	0.498000			O	BRAF	pilocytic astrocytoma								15	119					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57556127	57556127	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr12:57556127C>T	ENST00000243077.3	+	14	2696	c.2230C>T	c.(2230-2232)Cac>Tac	p.H744Y		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	744					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGAGCTGAACCACGCCTTTGG	0.527000													26	100					0	0	1	0	0
OSBPL9	114883	broad.mit.edu	37	1	52252272	52252272	+	Silent	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr1:52252272C>T	ENST00000371710.3	+	22	2219	c.2037C>T	c.(2035-2037)aaC>aaT	p.N679N	OSBPL9_ENST00000453295.1_Silent_p.N644N|OSBPL9_ENST00000447887.1_Silent_p.N671N|OSBPL9_ENST00000435686.2_Silent_p.N496N|OSBPL9_ENST00000428468.1_Silent_p.N661N|OSBPL9_ENST00000361556.5_Silent_p.N551N|OSBPL9_ENST00000371714.1_Silent_p.N648N|OSBPL9_ENST00000337809.4_Silent_p.N666N|OSBPL9_ENST00000486942.1_Silent_p.N483N|OSBPL9_ENST00000531828.1_Silent_p.N496N|OSBPL9_ENST00000462759.1_Silent_p.N483N|OSBPL9_ENST00000530544.1_Silent_p.N580N	NM_024586.5|NM_148906.2	NP_078862.4|NP_683704.2	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9	661					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|pancreas(1)|prostate(3)|skin(1)	18						AAGATCAGAACGAGTATGAAT	0.438000													9	34					0	0	1	0	0
SPATC1	375686	broad.mit.edu	37	8	145094826	145094826	+	Silent	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr8:145094826G>A	ENST00000377470.3	+	2	330	c.228G>A	c.(226-228)ccG>ccA	p.P76P	SPATC1_ENST00000447830.2_Silent_p.P76P	NM_198572.2	NP_940974.2	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	76	Necessary for targeting centrosomes (By similarity).									NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCCTGCCCCCGTCCCCAGCAG	0.632000													21	73					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233899438	233899438	+	Missense_Mutation	SNP	T	T	G			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr2:233899438T>G	ENST00000233840.3	+	2	814	c.814T>G	c.(814-816)Tgc>Ggc	p.C272G		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	272							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		GCCCCAGGGCTGCCAGGGGAG	0.682000													6	18					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96180767	96180767	+	Missense_Mutation	SNP	C	C	T	rs142996736		TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr12:96180767C>T	ENST00000343702.4	-	2	983	c.535G>A	c.(535-537)Gct>Act	p.A179T	NTN4_ENST00000538383.1_Missense_Mutation_p.A142T|NTN4_ENST00000553059.1_Missense_Mutation_p.A179T|NTN4_ENST00000344911.4_Missense_Mutation_p.A142T	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	179	Laminin N-terminal.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						GTACAAATAGCGCCCTTCTTG	0.438000													12	66					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649650	75649650	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chrX:75649650G>A	ENST00000361470.2	+	1	1605	c.1327G>A	c.(1327-1329)Gtg>Atg	p.V443M		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	443						dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						CAAGGCCTCCGTGGACTCAGA	0.537000													8	8					0	0	1	0	0
GHITM	27069	broad.mit.edu	37	10	85903820	85903820	+	Missense_Mutation	SNP	G	G	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr10:85903820G>T	ENST00000372134.3	+	4	492	c.299G>T	c.(298-300)gGc>gTc	p.G100V		NM_014394.2	NP_055209.2	Q9H3K2	GHITM_HUMAN	growth hormone inducible transmembrane protein	100					apoptosis	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(2)	10						TGCTACTATGGCTTGGGACTG	0.413000													17	62					3.99206e-14	4.22348e-14	1	1	0
KRT27	342574	broad.mit.edu	37	17	38933308	38933308	+	Silent	SNP	A	A	C			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr17:38933308A>C	ENST00000301656.3	-	8	1363	c.1323T>G	c.(1321-1323)acT>acG	p.T441T	KRT27_ENST00000540723.1_5'UTR	NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	441	Tail.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				TCTCTTCCACAGTGTGAACTC	0.413000													21	61					0	0	1	0	0
MC5R	4161	broad.mit.edu	37	18	13826283	13826283	+	Silent	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr18:13826283C>T	ENST00000324750.3	+	1	741	c.519C>T	c.(517-519)tgC>tgT	p.C173C		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	173					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						GCACGGGCTGCGGCATTGTCT	0.567000													102	373					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102187849	102187849	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr3:102187849G>A	ENST00000306176.1	+	8	951	c.851G>A	c.(850-852)cGa>cAa	p.R284Q	ZPLD1_ENST00000491959.1_Missense_Mutation_p.R268Q|ZPLD1_ENST00000466937.1_Missense_Mutation_p.R268Q	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	268	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						GAGAATGGCCGAAGCCAGCGG	0.478000													8	46					0	0	1	0	0
AHRR	57491	broad.mit.edu	37	5	413482	413482	+	Silent	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr5:413482C>T	ENST00000316418.5	+	5	431	c.387C>T	c.(385-387)gtC>gtT	p.V129V	AHRR_ENST00000512529.1_5'UTR|AHRR_ENST00000505113.1_Silent_p.V129V	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	129	PAS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			TTGCTCTGGTCGTGAGTGCAG	0.398000													21	76					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681032	100681032	+	Missense_Mutation	SNP	C	C	T	rs138732859		TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr7:100681032C>T	ENST00000306151.4	+	3	6399	c.6335C>T	c.(6334-6336)aCg>aTg	p.T2112M		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2112	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CTCAGCACCACGCCGGTGGCC	0.498000													46	298					0	0	1	0	0
SIAH3	283514	broad.mit.edu	37	13	46357873	46357873	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr13:46357873G>A	ENST00000400405.2	-	2	561	c.455C>T	c.(454-456)gCg>gTg	p.A152V		NM_198849.2	NP_942146.2	Q8IW03	SIAH3_HUMAN	siah E3 ubiquitin protein ligase family member 3	152					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			large_intestine(3)|lung(7)|ovary(1)|skin(1)	12						ATCAGCCGGCGCGGGGAGGTG	0.617000													13	26					0	0	1	0	0
ZDHHC5	25921	broad.mit.edu	37	11	57457663	57457663	+	Missense_Mutation	SNP	G	G	A	rs141814126		TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr11:57457663G>A	ENST00000287169.3	+	5	1907	c.545G>A	c.(544-546)cGc>cAc	p.R182H	ZDHHC5_ENST00000527985.1_Missense_Mutation_p.R129H	NM_015457.2	NP_056272.2	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC-type containing 5	182						integral to membrane	acyltransferase activity|zinc ion binding			endometrium(6)|kidney(3)|large_intestine(3)|lung(5)|skin(1)	18						TCAGGGGTCCGCACGGCTGTC	0.517000													4	91					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237777418	237777418	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr1:237777418G>A	ENST00000366574.2	+	37	5307	c.4990G>A	c.(4990-4992)Gtc>Atc	p.V1664I	RYR2_ENST00000542537.1_Missense_Mutation_p.V1648I|RYR2_ENST00000360064.6_Missense_Mutation_p.V1662I	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1664	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.V1662L(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTACTCAGCCGTCTGTGCTCT	0.517000													10	22					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433101	55433101	+	Silent	SNP	C	C	T	rs144378683		TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr11:55433101C>T	ENST00000314259.3	+	1	488	c.459C>T	c.(457-459)caC>caT	p.H153H		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H153H(1)		breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						GATTTATGCACGCAATGATAC	0.463000													20	66					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62131666	62131666	+	Missense_Mutation	SNP	T	T	G			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr17:62131666T>G	ENST00000433197.2	-	15	1992	c.1897A>C	c.(1897-1899)Aag>Cag	p.K633Q		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	633	Protein kinase.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						TGCCGGTCCTTCTCCGTGCAG	0.488000													5	16					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461396	11461396	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr12:11461396C>T	ENST00000279575.1	-	3	554	c.521G>A	c.(520-522)cGa>cAa	p.R174Q	PRB4_ENST00000445719.2_Intron|PRB4_ENST00000535904.1_Missense_Mutation_p.R174Q	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	237	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.		Missing (in allele S).	Missing (in Ref. 7; CAA30542).		extracellular region		p.R174Q(1)		breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						TCGGGCACTTCGGGACTTGTT	0.597000										HNSCC(22;0.051)			73	232					0	0	1	0	0
JAG2	3714	broad.mit.edu	37	14	105622205	105622205	+	Silent	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr14:105622205G>A	ENST00000331782.3	-	4	1000	c.597C>T	c.(595-597)gaC>gaT	p.D199D	RP11-44N21.4_ENST00000548203.1_RNA|JAG2_ENST00000347004.2_Silent_p.D199D	NM_002226.4	NP_002217.3	Q9Y219	JAG2_HUMAN	jagged 2	199	DSL.				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(7)|prostate(2)|skin(5)	22		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		AGTAGTTCTCGTCGCAGCGCA	0.627000													4	18					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126355498	126355498	+	Missense_Mutation	SNP	A	A	G			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr4:126355498A>G	ENST00000394329.3	+	7	7130	c.7117A>G	c.(7117-7119)Att>Gtt	p.I2373V	FAT4_ENST00000335110.5_Missense_Mutation_p.I671V	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2373	Cadherin 23.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TTTCACAACAATTCCTGAGGA	0.413000													23	84					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56307589	56307589	+	Silent	SNP	G	G	A	rs116391886	by1000genomes	TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr19:56307589G>A	ENST00000443188.1	-	8	2909	c.2199C>T	c.(2197-2199)agC>agT	p.S733S	NLRP11_ENST00000360133.3_Silent_p.S679S|NLRP11_ENST00000589093.1_Silent_p.S733S|NLRP11_ENST00000592953.1_Silent_p.S634S|NLRP11_ENST00000589824.2_Silent_p.S679S	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	733							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CTTCACATTCGCTGGCTCGCA	0.443000													12	52					0	0	1	0	0
SLC2A13	114134	broad.mit.edu	37	12	40345131	40345131	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr12:40345131G>A	ENST00000280871.4	-	4	1012	c.962C>T	c.(961-963)cCa>cTa	p.P321L	SLC2A13_ENST00000380858.1_Missense_Mutation_p.P321L	NM_052885.3	NP_443117.3	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 13	321						integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	29		Lung NSC(34;0.105)|all_lung(34;0.123)				TCGGCGAGTTGGGGGATAACT	0.373000										HNSCC(50;0.14)			6	45					0	0	1	0	0
EIF4ENIF1	56478	broad.mit.edu	37	22	31845480	31845480	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr22:31845480G>A	ENST00000397525.1	-	12	1845	c.1622C>T	c.(1621-1623)tCc>tTc	p.S541F	EIF4ENIF1_ENST00000397523.1_Missense_Mutation_p.S517F|EIF4ENIF1_ENST00000330125.5_Missense_Mutation_p.S541F|EIF4ENIF1_ENST00000382180.2_Missense_Mutation_p.S196F|EIF4ENIF1_ENST00000344710.5_Missense_Mutation_p.S366F	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	541						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						CAGAAGATTGGAAGAAGCAGG	0.478000													9	73					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126749159	126749159	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr3:126749159C>T	ENST00000393409.2	+	28	5135	c.5135C>T	c.(5134-5136)cCg>cTg	p.P1712L	PLXNA1_ENST00000251772.4_Missense_Mutation_p.P1689L	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	1712					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		TCAGCCCTGCCGCTGGCCATC	0.602000													22	80					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50659379	50659379	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr22:50659379C>T	ENST00000439308.2	-	16	3901	c.3409G>A	c.(3409-3411)Gtg>Atg	p.V1137M	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000248846.5_Missense_Mutation_p.V1137M	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1137	9 X 27 AA tandem repeats.				G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCGTTGGACACGTGCCCGTGG	0.622000													25	102					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075892	9075892	+	Silent	SNP	T	T	G			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr19:9075892T>G	ENST00000397910.4	-	3	11757	c.11554A>C	c.(11554-11556)Aga>Cga	p.R3852R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3853	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGCCCTTGTCTCTGAAAAGTT	0.493000													4	55					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113353895	113353895	+	Missense_Mutation	SNP	T	T	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr8:113353895T>A	ENST00000297405.5	-	42	6707	c.6463A>T	c.(6463-6465)Aat>Tat	p.N2155Y	CSMD3_ENST00000343508.3_Missense_Mutation_p.N2115Y|CSMD3_ENST00000352409.3_Missense_Mutation_p.N2085Y|CSMD3_ENST00000455883.2_Missense_Mutation_p.N2051Y	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2155	CUB 12.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTAGAAAAATTTACAAACTGG	0.353000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	17					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12666860	12666860	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr17:12666860G>A	ENST00000425538.1	+	14	3060	c.2860G>A	c.(2860-2862)Gcc>Acc	p.A954T	MYOCD_ENST00000343344.4_Missense_Mutation_p.A906T|RP11-1090M7.1_ENST00000584772.1_RNA	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	906					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding	p.A906T(1)		breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AGGCTTTAGCGCCCTCACCAC	0.517000													11	41					0	0	1	0	0
HSF2BP	11077	broad.mit.edu	37	21	44949704	44949704	+	Missense_Mutation	SNP	C	C	T	rs140530326	byFrequency	TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr21:44949704C>T	ENST00000291560.2	-	9	1266	c.935G>A	c.(934-936)cGc>cAc	p.R312H	HSF2BP_ENST00000542962.1_Missense_Mutation_p.R237H	NM_007031.1	NP_008962.1	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding protein	312					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			kidney(2)|large_intestine(3)|prostate(1)|skin(1)	7				STAD - Stomach adenocarcinoma(101;0.18)		GCGGGGGTTGCGGCTCTTGGA	0.592000													28	58					0	0	1	0	0
ZNF460	10794	broad.mit.edu	37	19	57802451	57802451	+	Missense_Mutation	SNP	G	G	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr19:57802451G>T	ENST00000360338.3	+	3	864	c.542G>T	c.(541-543)tGc>tTc	p.C181F	ZNF460_ENST00000537645.1_Missense_Mutation_p.C140F	NM_006635.3	NP_006626.3	Q14592	ZN460_HUMAN	zinc finger protein 460	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AATGAGAATTGCTTCCTTGTT	0.433000													17	76					3.45872e-05	3.50676e-05	1	1	0
SLFN13	146857	broad.mit.edu	37	17	33767661	33767661	+	Missense_Mutation	SNP	T	T	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr17:33767661T>A	ENST00000285013.6	-	6	2922	c.2647A>T	c.(2647-2649)Atc>Ttc	p.I883F	SLFN13_ENST00000533791.1_Missense_Mutation_p.I883F|SLFN13_ENST00000360502.2_Missense_Mutation_p.I565F|SLFN13_ENST00000542635.1_Missense_Mutation_p.I883F|SLFN13_ENST00000534689.1_Missense_Mutation_p.I565F|SLFN13_ENST00000526861.1_Missense_Mutation_p.I883F	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	883						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCCAGACAGATCAGAATATTG	0.448000													24	110					0	0	1	0	0
ANKRD13C	81573	broad.mit.edu	37	1	70779456	70779456	+	Silent	SNP	T	T	C			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr1:70779456T>C	ENST00000370944.4	-	5	994	c.681A>G	c.(679-681)ctA>ctG	p.L227L	ANKRD13C_ENST00000262346.6_Silent_p.L192L	NM_030816.4	NP_110443.3	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	227					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	19						AGTGAAGTTCTAGATAAAAGT	0.289000													16	65					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170093742	170093742	+	Missense_Mutation	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr2:170093742C>T	ENST00000263816.3	-	28	4847	c.4562G>A	c.(4561-4563)cGt>cAt	p.R1521H		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1521					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTAAAGATTACGACCTACCCA	0.363000													15	49					0	0	1	0	0
MC2R	0	broad.mit.edu	37	18	13884771	13884771	+	Silent	SNP	G	G	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr18:13884771G>T	ENST00000327606.3	-	2	927	c.747C>A	c.(745-747)ccC>ccA	p.P249P		NM_000529.2	NP_000520.1	Q01718	ACTHR_HUMAN	melanocortin 2 receptor (adrenocorticotropic hormone)	249					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(8)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30					Corticotropin(DB01285)|Cosyntropin(DB01284)	AGGCGCAGTAGGGGTTACTTG	0.542000													8	37					7.48243e-07	7.8031e-07	1	1	0
IKZF1	10320	broad.mit.edu	37	7	50468070	50468070	+	Silent	SNP	C	C	T			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr7:50468070C>T	ENST00000331340.3	+	8	1460	c.1305C>T	c.(1303-1305)taC>taT	p.Y435Y	IKZF1_ENST00000439701.1_Silent_p.Y393Y|IKZF1_ENST00000438033.1_Silent_p.Y348Y|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000343574.5_Silent_p.Y348Y|IKZF1_ENST00000359197.5_Silent_p.Y393Y|IKZF1_ENST00000346667.4_Silent_p.Y205Y|IKZF1_ENST00000349824.4_Silent_p.Y292Y|IKZF1_ENST00000357364.4_Silent_p.Y348Y	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	435					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				ACCGCGCCTACGACCTGCTGC	0.672000			"""D,T"""	BCL6	"""ALL, DLBCL"""								7	34					0	0	1	0	0
PPAN	56342	broad.mit.edu	37	19	10224746	10224746	+	Missense_Mutation	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr19:10224746G>A	ENST00000556468.1	+	13	1744	c.1717G>A	c.(1717-1719)Ggc>Agc	p.G573S	P2RY11_ENST00000321826.4_Missense_Mutation_p.G153S|PPAN-P2RY11_ENST00000428358.1_3'UTR|PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.G573S					peter pan homolog (Drosophila)											endometrium(3)|liver(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GAGCGCTGCCGGCTGGGTCCT	0.697000													8	28					0	0	1	0	0
BAIAP2	10458	broad.mit.edu	37	17	79059507	79059507	+	Silent	SNP	G	G	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr17:79059507G>A	ENST00000321300.6	+	5	426	c.333G>A	c.(331-333)ctG>ctA	p.L111L	BAIAP2_ENST00000573894.1_3'UTR|BAIAP2_ENST00000575712.1_Silent_p.L111L|BAIAP2_ENST00000392411.3_Silent_p.L33L|BAIAP2_ENST00000428708.2_Silent_p.L111L|BAIAP2_ENST00000321280.7_Silent_p.L111L|BAIAP2_ENST00000435091.3_Silent_p.L111L|BAIAP2_ENST00000575245.1_Silent_p.L144L	NM_001144888.1|NM_017451.2	NP_001138360.1|NP_059345.1	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2	111	IMD.				axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)	18	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			AGGTGGAGCTGGACTCCAGGT	0.587000													17	43					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47161888	47161891	+	Frame_Shift_Del	DEL	CTCT	CTCT	-			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr3:47161888_47161891delCTCT	ENST00000409792.3	-	3	4277_4280	c.4235_4238delAGAG	c.(4234-4239)gtfs	p.ES1412fs		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TTCAGAATCACTCTCTATTTCCTG	0.412			"""N, F, S, Mis"""		clear cell renal carcinoma								12	54	---	---	---	---					
ATP8A1	10396	broad.mit.edu	37	4	42626599	42626600	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr4:42626599_42626600delAA	ENST00000381668.5	-	4	547_548	c.316_317delTT	c.(316-318)afs	p.L106fs	ATP8A1_ENST00000264449.10_Frame_Shift_Del_p.L106fs	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	106					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	TAAAATAAATAAGAGAGGAACC	0.292													9	38	---	---	---	---					
DLX6	1750	broad.mit.edu	37	7	96635420	96635421	+	In_Frame_Ins	INS	-	-	GCC			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr7:96635420_96635421insGCC	ENST00000518156.2	+	1	561_562	c.131_132insGCC	c.(130-132)ccc>cGCCcc	p.43_44insR	DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000437331.2_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000605417.1_RNA|DLX6_ENST00000007660.5_Intron|DLX6-AS1_ENST00000430027.2_RNA|DLX6-AS1_ENST00000458352.2_RNA|DLX6-AS1_ENST00000437541.1_RNA			P56179	DLX6_HUMAN	distal-less homeobox 6	0					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(2)|urinary_tract(1)	12	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					caacagcaacagccgccgccgc	0.698													2	4	---	---	---	---					
ZNF658	26149	broad.mit.edu	37	9	40789482	40789483	+	Splice_Site	INS	-	-	A			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr9:40789482_40789483insA	ENST00000602553.1	-	2	94		c.e2-2		ZNF658_ENST00000441795.1_Splice_Site|ZNF658_ENST00000377626.3_Intron			Q5TYW1	ZN658_HUMAN	zinc finger protein 658						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTCATGTGCCTAAAAAAAAAAA	0.426													3	5	---	---	---	---					
RP11-383M4.6	0	broad.mit.edu	37	9	84564499	84564500	+	RNA	DEL	CA	CA	-			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr9:84564499_84564500delCA	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							GAATAGATATCACCTGTCCCCA	0.505													2	4	---	---	---	---					
BCAR1	9564	broad.mit.edu	37	16	75271148	75271148	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr16:75271148delG	ENST00000546196.1	-	3	2293	c.641delC	c.(640-642)cgfs	p.P214fs	BCAR1_ENST00000542031.2_Frame_Shift_Del_p.P241fs|BCAR1_ENST00000538440.2_Frame_Shift_Del_p.P243fs|BCAR1_ENST00000535626.2_Frame_Shift_Del_p.P95fs|BCAR1_ENST00000566982.1_5'UTR|BCAR1_ENST00000420641.3_Frame_Shift_Del_p.P261fs|BCAR1_ENST00000418647.3_Frame_Shift_Del_p.P289fs|BCAR1_ENST00000393420.6_Frame_Shift_Del_p.P243fs|BCAR1_ENST00000393422.2_Frame_Shift_Del_p.P261fs|BCAR1_ENST00000162330.5_Frame_Shift_Del_p.P243fs			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	243	Substrate for kinases (By similarity).				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		CTGTGGCCCCGGGGCCAGCAG	0.697													2	4	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs|CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													11	42	---	---	---	---					
PDE4C	5143	broad.mit.edu	37	19	18337154	18337154	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr19:18337154delG	ENST00000262805.11	-	1	131	c.72delC	c.(70-72)ccfs	p.P24fs	PDE4C_ENST00000594465.2_Intron|PDE4C_ENST00000594617.2_Intron|PDE4C_ENST00000355502.3_Intron	NM_001098818.2	NP_001092288.1	Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	433					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	TGAAGAGCCCGGGGGAGCCGC	0.741													2	4	---	---	---	---					
FBL	2091	broad.mit.edu	37	19	40331409	40331409	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HT-A74H-01A-11D-A32B-08	TCGA-HT-A74H-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c03738-63f8-41c8-9dfc-4dcf447f2b95	f03d1a78-0b2f-4725-8dd3-d31d00507dcd	g.chr19:40331409delC	ENST00000221801.3	-	2	142	c.29delG	c.(28-30)gtfs	p.G11fs		NM_001436.3	NP_001427.2	P22087	FBRL_HUMAN	fibrillarin	11	DMA/Gly-rich.				rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		GCCAAAGCCACCCCCACGGGG	0.607													2	4	---	---	---	---					
