Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PFKL	5211	broad.mit.edu	37	21	45726635	45726635	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr21:45726635G>A	ENST00000403390.1	+	3	298	c.298G>A	c.(298-300)Gag>Aag	p.E100K	PFKL_ENST00000349048.4_Missense_Mutation_p.E53K|PFKL_ENST00000496824.1_3'UTR			P17858	K6PL_HUMAN	phosphofructokinase, liver	53					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		CCTCATCTACGAGGTAAGGCC	0.607000													19	28					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195512148	195512148	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr3:195512148G>C	ENST00000463781.3	-	2	6762	c.6303C>G	c.(6301-6303)gaC>gaG	p.D2101E	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.D2101E	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	874	EGF-like 2.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CTGAGGAAGCGTCGGTGACAA	0.567000													3	12					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132527130	132527130	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr11:132527130T>C	ENST00000331898.7	-	2	830	c.252A>G	c.(250-252)atA>atG	p.I84M	OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000374778.4_Missense_Mutation_p.I43M|OPCML_ENST00000524381.1_Missense_Mutation_p.I77M|OPCML_ENST00000541867.1_Missense_Mutation_p.I84M	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	84	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CACGAGGGTCTATGGACCACT	0.542000													23	166					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75331188	75331188	+	Silent	SNP	G	G	A			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr10:75331188G>A	ENST00000339859.4	-	3	331	c.231C>T	c.(229-231)tgC>tgT	p.C77C	USP54_ENST00000319786.7_Silent_p.C77C|USP54_ENST00000428547.1_Silent_p.C77C|USP54_ENST00000408019.1_Silent_p.C77C|USP54_ENST00000394811.2_5'UTR			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	77					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					CCTTGAGAGCGCAAAAGATGC	0.433000													4	147					0	0	1	0	0
RBAK	57786	broad.mit.edu	37	7	5112572	5112572	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr7:5112572C>T	ENST00000407184.1	+	8	721	c.455C>T	c.(454-456)aCg>aTg	p.T152M	RBAK_ENST00000396904.2_3'UTR|RBAK_ENST00000498308.1_3'UTR			Q9NYW8	RBAK_HUMAN	RB-associated KRAB zinc finger	0					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(2)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	10		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		CTGGCGGAGACGGAGAGCTGC	0.662000													5	149					0	0	1	0	0
GSTM2	2946	broad.mit.edu	37	1	110210764	110210764	+	Silent	SNP	C	C	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr1:110210764C>T	ENST00000369831.2	+	1	121	c.27C>T	c.(25-27)aaC>aaT	p.N9N	GSTM2_ENST00000464206.1_3'UTR|GSTM2_ENST00000442650.1_Silent_p.N9N|GSTM2_ENST00000414179.2_5'UTR|GSTM2_ENST00000369829.2_Silent_p.N9N|GSTM2_ENST00000460717.3_Silent_p.N9N|GSTM2_ENST00000241337.4_Silent_p.N9N|GSTM2_ENST00000369827.3_Silent_p.N7N					glutathione S-transferase mu 2 (muscle)											kidney(1)|large_intestine(2)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	11		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)		GGTACTGGAACATCCGCGGGG	0.677000													29	29					0	0	1	0	0
GNB3	2784	broad.mit.edu	37	12	6950780	6950780	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr12:6950780C>G	ENST00000229264.3	+	4	493	c.88C>G	c.(88-90)Ctg>Gtg	p.L30V	GNB3_ENST00000435982.2_Missense_Mutation_p.L30V	NM_002075.2	NP_002066.1	P16520	GBB3_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 3	30					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|stomach(1)	20						TGACGTTACTCTGGCAGAGGT	0.642000													3	31					0	0	1	0	0
AMT	275	broad.mit.edu	37	3	49459637	49459637	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr3:49459637G>A	ENST00000273588.3	-	2	460	c.158C>T	c.(157-159)gCg>gTg	p.A53V	AMT_ENST00000546031.1_Intron|AMT_ENST00000458307.2_Missense_Mutation_p.A53V|AMT_ENST00000395338.2_Missense_Mutation_p.A53V|AMT_ENST00000476226.1_5'UTR|AMT_ENST00000538581.1_Intron	NM_000481.3	NP_000472.2	P48728	GCST_HUMAN	aminomethyltransferase	53					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	ACTCCAACCCGCAAACGCCAC	0.627000													5	302					0	0	1	0	0
FOXA2	3170	broad.mit.edu	37	20	22563390	22563390	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr20:22563390C>T	ENST00000419308.2	-	2	674	c.472G>A	c.(472-474)Gca>Aca	p.A158T	FOXA2_ENST00000377115.4_Missense_Mutation_p.A158T|FOXA2_ENST00000319993.4_Missense_Mutation_p.A164T	NM_021784.4	NP_068556.2	Q9Y261	FOXA2_HUMAN	forkhead box A2	158					cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|urinary_tract(1)	22	Lung NSC(19;0.188)					GGCGGCTTTGCGTGCGTGTAG	0.627000													4	209					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33464075	33464075	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr9:33464075C>T	ENST00000379471.2	-	22	2951	c.2864G>A	c.(2863-2865)cGc>cAc	p.R955H	NOL6_ENST00000464829.1_Intron|NOL6_ENST00000455041.2_Missense_Mutation_p.R903H			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	955					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding	p.R955H(1)		endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		AGAGTTTTTGCGGTCTTGGGG	0.567000													5	239					0	0	1	0	0
PDGFC	56034	broad.mit.edu	37	4	157771503	157771503	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr4:157771503T>C	ENST00000502773.1	-	2	674	c.184A>G	c.(184-186)Agg>Ggg	p.R62G	PDGFC_ENST00000541126.1_Intron|PDGFC_ENST00000422544.2_Missense_Mutation_p.R62G	NM_016205.2	NP_057289.1	Q9NRA1	PDGFC_HUMAN	platelet derived growth factor C	62	CUB.				central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		TGAGGAAACCTTGGGCTGTGA	0.358000													49	57					0	0	1	0	0
NHLRC2	374354	broad.mit.edu	37	10	115664616	115664616	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr10:115664616C>T	ENST00000369301.3	+	10	1957	c.1745C>T	c.(1744-1746)cCg>cTg	p.P582L		NM_198514.3	NP_940916.2	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	582					cell redox homeostasis					breast(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	15				Epithelial(162;0.017)|all cancers(201;0.0187)		GTAGATGGCCCGTTCCTAGTA	0.408000													29	82					0	0	1	0	0
IGHV1OR15-9	0	broad.mit.edu	37	15	20169960	20169960	+	RNA	SNP	G	G	A	rs150674714	by1000genomes	TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr15:20169960G>A	ENST00000338912.5	-	0	311																											CAGATCTCAGGCTGCTTAGCT	0.527000													5	509					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70819927	70819927	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr5:70819927G>A	ENST00000358731.4	+	25	5812	c.5549G>A	c.(5548-5550)cGg>cAg	p.R1850Q	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	1850					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AAACGAGTTCGGGGTAAGACC	0.453000													4	163					0	0	1	0	0
SCRT1	83482	broad.mit.edu	37	8	145556985	145556985	+	Silent	SNP	G	G	A			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr8:145556985G>A	ENST00000332135.4	-	2	1020	c.909C>T	c.(907-909)caC>caT	p.H303H		NM_031309.4	NP_112599.1	Q9BWW7	SCRT1_HUMAN	scratch family zinc finger 1	303						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|upper_aerodigestive_tract(1)	3	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.35e-39)|all cancers(56;1.37e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			TGCACTGGAAGTGCTTGAAGG	0.652000													12	24					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167849749	167849749	+	Silent	SNP	G	G	A			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr1:167849749G>A	ENST00000367848.1	-	10	1340	c.843C>T	c.(841-843)tgC>tgT	p.C281C	ADCY10_ENST00000545172.1_Silent_p.C220C|ADCY10_ENST00000367851.4_Silent_p.C373C			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	373					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						GGACTTGAGAGCAGAAGTCAA	0.517000													9	126					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								56	100					0	0	1	0	0
TBX4	9496	broad.mit.edu	37	17	59560289	59560289	+	Silent	SNP	C	C	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr17:59560289C>T	ENST00000393853.4	+	9	1216	c.1053C>T	c.(1051-1053)tgC>tgT	p.C351C	TBX4_ENST00000240335.1_Silent_p.C350C|TBX4_ENST00000589449.1_3'UTR			P57082	TBX4_HUMAN	T-box 4	350					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						ACTTACCTTGCAAGCGATCCT	0.567000													16	25					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2297883	2297883	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr20:2297883T>C	ENST00000381458.5	+	6	902	c.839T>C	c.(838-840)cTc>cCc	p.L280P	TGM3_ENST00000463090.1_3'UTR	NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	280					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	GCTGGGACCCTCAACACAGGT	0.577000													4	209					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198950470	198950470	+	Silent	SNP	G	G	A	rs142477843		TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr2:198950470G>A	ENST00000428675.1	+	2	2627	c.2229G>A	c.(2227-2229)ggG>ggA	p.G743G	PLCL1_ENST00000437704.2_Silent_p.G645G	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	743	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	GTGCCAAAGGGGATGTCATAG	0.433000													14	165					0	0	1	0	0
BCAR1	9564	broad.mit.edu	37	16	75276756	75276756	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr16:75276756G>A	ENST00000546196.1	-	2	1810	c.158C>T	c.(157-159)cCg>cTg	p.P53L	BCAR1_ENST00000162330.5_Missense_Mutation_p.P82L|BCAR1_ENST00000420641.3_Missense_Mutation_p.P100L|BCAR1_ENST00000535626.2_Intron|BCAR1_ENST00000418647.3_Missense_Mutation_p.P128L|BCAR1_ENST00000542031.2_Missense_Mutation_p.P80L|BCAR1_ENST00000393420.6_Missense_Mutation_p.P82L|BCAR1_ENST00000393422.2_Missense_Mutation_p.P100L|BCAR1_ENST00000538440.2_Missense_Mutation_p.P82L			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	82	SH3.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		AGGCTGGGCCGGGGTGGCGGG	0.687000													4	91					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110895028	110895028	+	Silent	SNP	T	T	C			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr13:110895028T>C	ENST00000375820.4	-	2	259	c.138A>G	c.(136-138)ggA>ggG	p.G46G	COL4A1_ENST00000543140.1_Silent_p.G46G	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	46					angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TCACCTTTTGTCCCTTCACTC	0.403000													195	304					0	0	1	0	0
PHOX2B	8929	broad.mit.edu	37	4	41750611	41750611	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr4:41750611T>C	ENST00000226382.2	-	1	376	c.17A>G	c.(16-18)tAt>tGt	p.Y6C	RP11-227F19.1_ENST00000508038.1_RNA	NM_003924.3	NP_003915.2	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	6					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	30						GAGGTAAGAATATTCCATTTT	0.483000			"""Mis, F"""		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				9	64					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21730847	21730847	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr17:21730847G>T	ENST00000584755.1	+	2	546	c.149G>T	c.(148-150)cGg>cTg	p.R50L	UBBP4_ENST00000578713.1_Missense_Mutation_p.R50L|UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000584398.1_Intron																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GGCAAGCAGCGGGAAGATGGC	0.522000													4	92					0.150653	0.150653	1	1	0
SPP1	6696	broad.mit.edu	37	4	88898248	88898248	+	Splice_Site	SNP	A	A	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr4:88898248A>T	ENST00000237623.7	+	3	240	c.93_splice	c.e3+1	p.Q31_splice	SPP1_ENST00000395080.3_Splice_Site_p.Q31_splice|SPP1_ENST00000360804.4_Splice_Site_p.Q31_splice|SPP1_ENST00000509659.1_3'UTR	NM_000582.2	NP_000573.1	P10451	OSTP_HUMAN	secreted phosphoprotein 1	31					biomineral tissue development|cell adhesion|decidualization|embryo implantation|ossification|response to vitamin D	extracellular space	cytokine activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(3)|skin(1)	13		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-05)		GAGGAAAAGCAGGTAAGCATC	0.358000													54	104					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197061121	197061121	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr1:197061121A>T	ENST00000367409.4	-	22	9616	c.9360T>A	c.(9358-9360)aaT>aaA	p.N3120K	ASPM_ENST00000367408.1_Missense_Mutation_p.N785K|ASPM_ENST00000294732.7_Missense_Mutation_p.N1535K	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	3120					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TTCTAACAGCATTCAGGTGAT	0.363000													10	144					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66765616	66765616	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chrX:66765616A>G	ENST00000374690.3	+	1	1152	c.628A>G	c.(628-630)Aga>Gga	p.R210G	AR_ENST00000396044.3_Missense_Mutation_p.R210G|AR_ENST00000504326.1_Missense_Mutation_p.R210G|AR_ENST00000513847.1_3'UTR	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	208	Modulating.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CAGCAGCGGGAGAGCGAGGGA	0.577000									Androgen Insensitivity Syndrome				3	33					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	160980358	160980358	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr2:160980358C>T	ENST00000283249.2	-	12	2162	c.1925G>A	c.(1924-1926)cGa>cAa	p.R642Q	ITGB6_ENST00000409872.1_Missense_Mutation_p.R642Q|ITGB6_ENST00000409967.2_Intron|ITGB6_ENST00000428609.2_Missense_Mutation_p.R600Q			P18564	ITB6_HUMAN	integrin, beta 6	642					cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						ACATTCTTCTCGGGCTTGGCC	0.453000													21	146					0	0	1	0	0
CHMP7	91782	broad.mit.edu	37	8	23117744	23117744	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr8:23117744G>A	ENST00000397677.1	+	10	1856	c.1208G>A	c.(1207-1209)cGc>cAc	p.R403H	CHMP7_ENST00000520102.1_3'UTR|CHMP7_ENST00000313219.7_Missense_Mutation_p.R403H	NM_152272.3	NP_689485.1	Q8WUX9	CHMP7_HUMAN	charged multivesicular body protein 7	403					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GACAACCCCCGCAATAGGCAT	0.463000													4	207					0	0	1	0	0
MYO1C	4641	broad.mit.edu	37	17	1375272	1375272	+	Silent	SNP	C	C	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr17:1375272C>T	ENST00000359786.5	-	19	2274	c.1950G>A	c.(1948-1950)ggG>ggA	p.G650G	MYO1C_ENST00000361007.2_Silent_p.G615G|MYO1C_ENST00000545534.2_Silent_p.G626G|MYO1C_ENST00000438665.2_Silent_p.G631G|MYO1C_ENST00000575158.1_Silent_p.G615G	NM_001080779.1	NP_001074248.1	O00159	MYO1C_HUMAN	myosin IC	650	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TTTCCAACAGCCCCAGGTACT	0.657000													14	216					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43316423	43316423	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr18:43316423C>A	ENST00000321925.4	+	6	705	c.473C>A	c.(472-474)cCa>cAa	p.P158Q	SLC14A1_ENST00000436407.3_Missense_Mutation_p.P214Q|SLC14A1_ENST00000589700.1_Missense_Mutation_p.P158Q|SLC14A1_ENST00000535474.1_Missense_Mutation_p.P26Q|SLC14A1_ENST00000591943.1_Intron|SLC14A1_ENST00000502059.2_Missense_Mutation_p.P50Q|SLC14A1_ENST00000402943.2_Missense_Mutation_p.P53Q|RP11-116O18.3_ENST00000586213.1_RNA|SLC14A1_ENST00000415427.3_Missense_Mutation_p.P214Q|SLC14A1_ENST00000586142.1_Missense_Mutation_p.P158Q|RP11-116O18.3_ENST00000589510.1_RNA	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	158						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						TTTTTTAGCCCAATTTTCTCA	0.473000													4	220					3.59834e-05	3.68829e-05	1	1	0
TMEM62	80021	broad.mit.edu	37	15	43473409	43473409	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr15:43473409G>A	ENST00000260403.2	+	13	1796	c.1517G>A	c.(1516-1518)gGc>gAc	p.G506D	EPB42_ENST00000563128.1_Intron|TMEM62_ENST00000569369.1_3'UTR	NM_024956.3	NP_079232.3	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	506						integral to membrane				breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		ATCATTGATGGCAAATTTGGT	0.338000													5	367					0	0	1	0	0
MARCKSL1	65108	broad.mit.edu	37	1	32800637	32800637	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr1:32800637G>A	ENST00000329421.7	-	2	494	c.149C>T	c.(148-150)cCt>cTt	p.P50L		NM_023009.6	NP_075385.1	P49006	MRP_HUMAN	MARCKS-like 1	50						plasma membrane	calmodulin binding			breast(1)|large_intestine(3)|lung(1)|ovary(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TCCGTTCACAGGGGGCGACTC	0.642000													78	31					0	0	1	0	0
FRRS1	391059	broad.mit.edu	37	1	100194159	100194159	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr1:100194159C>T	ENST00000414213.1	-	9	1497	c.896G>A	c.(895-897)gGt>gAt	p.G299D	FRRS1_ENST00000287474.5_Missense_Mutation_p.G299D			Q6ZNA5	FRRS1_HUMAN	ferric-chelate reductase 1	299	DOMON.				electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	26		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		CTGCATAACACCGTCCGCCAA	0.393000													58	35					0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32475056	32475056	+	Frame_Shift_Del	DEL	T	T	-			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr2:32475056delT	ENST00000404025.2	-	5	2365	c.1877delA	c.(1876-1878)agfs	p.K626fs	NLRC4_ENST00000402280.1_Frame_Shift_Del_p.K626fs|NLRC4_ENST00000360906.5_Frame_Shift_Del_p.K626fs|NLRC4_ENST00000342905.6_Intron			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	626					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TTCTGCAGCCTTTTCCCATGA	0.458													7	462	---	---	---	---					
MUC4	4585	broad.mit.edu	37	3	195512373	195512374	+	In_Frame_Ins	INS	-	-	GAT	rs63118461	by1000genomes	TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr3:195512373_195512374insGAT	ENST00000463781.3	-	2	6536_6537	c.6077_6078insATC	c.(6076-6078)tac>tATCac	p.2026_2027insH	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_In_Frame_Ins_p.2026_2027insH|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	798					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.S2026_T2027insS(3)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTCACCAGTGGATGCTGAGGA	0.579													3	3	---	---	---	---					
MFAP3L	9848	broad.mit.edu	37	4	170926744	170926746	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr4:170926744_170926746delCTT	ENST00000361618.3	-	2	590_592	c.283_285delAAG	c.(283-285)del	p.K95del	MFAP3L_ENST00000393702.3_In_Frame_Del_p.K95del|MFAP3L_ENST00000506110.1_In_Frame_Del_p.K95del	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	95	Ig-like C2-type.					integral to membrane|plasma membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		CTCCTCTCTCCTTCTCATCCTCT	0.424													22	416	---	---	---	---					
FAM66E	0	broad.mit.edu	37	8	7829133	7829134	+	RNA	DEL	TG	TG	-			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr8:7829133_7829134delTG	ENST00000533615.1	+	0	1153																											tatttgtgtttgtgtgtgtgtg	0.490													3	4	---	---	---	---					
NOTCH1	4851	broad.mit.edu	37	9	139413070	139413072	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr9:139413070_139413072delAGA	ENST00000277541.6	-	6	1145_1147	c.1070_1072delTCT	c.(1069-1074)tac>t	p.FY357del		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	357	EGF-like 9; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.F357delF(4)		breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CACTCGCAGTAGAAGGAGGCCAC	0.655			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			10	32	---	---	---	---					
KCNIP2	30819	broad.mit.edu	37	10	103589642	103589642	+	Frame_Shift_Del	DEL	G	G	-			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr10:103589642delG	ENST00000356640.2	-	3	457	c.182delC	c.(181-183)cafs	p.P61fs	KCNIP2_ENST00000370046.1_Intron|KCNIP2_ENST00000343195.4_Intron|KCNIP2_ENST00000358038.3_Intron|KCNIP2_ENST00000355657.2_5'UTR|KCNIP2_ENST00000348850.5_Intron|KCNIP2_ENST00000353068.3_Intron|KCNIP2_ENST00000461105.1_Frame_Shift_Del_p.P76fs	NM_014591.4|NM_173191.2	NP_055406.2|NP_775283.1	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2	61					clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		GAGGGAGGCTGGGGCGGCTAA	0.667													2	4	---	---	---	---					
SLC7A7	9056	broad.mit.edu	37	14	23242852	23242856	+	Frame_Shift_Del	DEL	CTCTC	CTCTC	-			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr14:23242852_23242856delCTCTC	ENST00000397532.3	-	10	2024_2028	c.1499_1503delGAGAG	c.(1498-1503)gfs	p.GE500fs	SLC7A7_ENST00000285850.7_Frame_Shift_Del_p.GE500fs|SLC7A7_ENST00000555702.1_Frame_Shift_Del_p.GE500fs|SLC7A7_ENST00000554517.1_Frame_Shift_Del_p.GE234fs|SLC7A7_ENST00000554061.1_5'UTR|SLC7A7_ENST00000397529.2_Frame_Shift_Del_p.GE500fs|SLC7A7_ENST00000397528.4_Frame_Shift_Del_p.GE500fs			Q9UM01	YLAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7	500					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		GCTTGGGCATCTCTCCTCCATCTTC	0.473													20	72	---	---	---	---					
ZC3H18	124245	broad.mit.edu	37	16	88677692	88677695	+	Frame_Shift_Del	DEL	GAGA	GAGA	-	rs145094173		TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr16:88677692_88677695delGAGA	ENST00000301011.5	+	8	1423_1426	c.1223_1226delGAGA	c.(1222-1227)cgfs	p.RE410fs	ZC3H18_ENST00000452588.2_Frame_Shift_Del_p.RE434fs	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	410						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		gagcgggagcgagagagagagaac	0.647													10	56	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42798857	42798858	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr19:42798857_42798858delCT	ENST00000572681.2	+	20	7215_7216	c.7147_7148delCT	c.(7147-7149)cfs	p.L2383fs	CIC_ENST00000575354.2_Frame_Shift_Del_p.L1477fs|CIC_ENST00000160740.3_Frame_Shift_Del_p.L1475fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	1477					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GGTCATGCAGCTCTTTCAGGAC	0.604			"""Mis, F, S"""		oligodendroglioma								74	50	---	---	---	---					
ZNF335	63925	broad.mit.edu	37	20	44579160	44579162	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr20:44579160_44579162delCTT	ENST00000322927.2	-	21	3362_3364	c.3262_3264delAAG	c.(3262-3264)del	p.K1088del	ZNF335_ENST00000426788.1_In_Frame_Del_p.K933del	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1088					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GACGCAGGTCCTTCTTGTTCTTG	0.601													34	376	---	---	---	---					
MIR3648	0	broad.mit.edu	37	21	9825838	9825839	+	RNA	INS	-	-	GCG	rs3052281		TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr21:9825838_9825839insGCG	ENST00000581792.1	+	0	7_8					NR_037421.1																						cggccgcgactgcggcggcggt	0.842													4	3	---	---	---	---					
APP	351	broad.mit.edu	37	21	27394182	27394184	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr21:27394182_27394184delGTG	ENST00000358918.3	-	6	1036_1038	c.837_839delCAC	c.(835-840)aca>ac	p.TT279del	APP_ENST00000448388.2_In_Frame_Del_p.TT244del|APP_ENST00000346798.3_In_Frame_Del_p.TT279del|APP_ENST00000440126.3_In_Frame_Del_p.TT274del|APP_ENST00000439274.2_In_Frame_Del_p.TT223del|APP_ENST00000474136.1_5'UTR|APP_ENST00000359726.3_In_Frame_Del_p.TT279del|APP_ENST00000357903.3_In_Frame_Del_p.TT279del|APP_ENST00000354192.3_In_Frame_Del_p.TT223del|APP_ENST00000348990.5_In_Frame_Del_p.TT279del	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	279	Poly-Thr.				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				CACAGACTCTgtggtggtggtgg	0.522													7	78	---	---	---	---					
KIAA0930	23313	broad.mit.edu	37	22	45601748	45601749	+	Frame_Shift_Ins	INS	-	-	G			TCGA-S9-A6U5-01A-12D-A33T-08	TCGA-S9-A6U5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6638014a-2392-40ed-b0e1-0d44f1df57ba	85191ce5-9e6c-45f6-82d9-5df7f9a7eeb5	g.chr22:45601748_45601749insG	ENST00000336156.4	-	3	326_327	c.261_262insC	c.(259-264)tcagaafs	p.E88fs	KIAA0930_ENST00000251993.7_Frame_Shift_Ins_p.E93fs|KIAA0930_ENST00000391627.2_Frame_Shift_Ins_p.E54fs|KIAA0930_ENST00000443310.3_Frame_Shift_Ins_p.E70fs	NM_001009880.1	NP_001009880.1	Q6ICG6	K0930_HUMAN	KIAA0930	88							protein binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|urinary_tract(1)	15						GGCAGCTTCTTGGAGTCCCGCC	0.634													55	60	---	---	---	---					
