Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
WRAP73	49856	broad.mit.edu	37	1	3548093	3548093	+	Missense_Mutation	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr1:3548093C>T	uc001ako.3	-	10	1285	c.1177G>A	c.(1177-1179)Gga>Aga	p.G393R	WRAP73_uc001akn.3_Missense_Mutation_p.G393R	NM_017818	NP_060288	Q9P2S5	WRP73_HUMAN	Homo sapiens WD repeat containing, antisense to TP73 (WRAP73), mRNA.	393						centrosome	protein binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|pancreas(1)	12						CTGCTGCCTCCCGTGCAGATG	0.667												
OMA1	115209	broad.mit.edu	37	1	58946683	58946683	+	Missense_Mutation	SNP	T	T	C	rs71730803		TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr1:58946683T>C	uc001cyy.3	-	8	1617	c.1529A>G	c.(1528-1530)gAg>gGg	p.E510G	DAB1_uc001cyt.1_Intron|OMA1_uc001cyx.1_Intron	NM_145243	NP_660286	Q96E52	OMA1_HUMAN	Homo sapiens OMA1 zinc metallopeptidase homolog (S. cerevisiae) (OMA1), mRNA.	510					proteolysis	integral to membrane|mitochondrial membrane	metal ion binding|metalloendopeptidase activity			NS(1)|breast(1)|large_intestine(6)|liver(2)|lung(6)|prostate(1)|skin(1)	18	all_cancers(7;6.54e-05)					TGGTATTTGCTCCTGTTTTTG	0.328												
GJA8	2703	broad.mit.edu	37	1	147380346	147380346	+	Silent	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr1:147380346G>A	uc021ovm.1	+	0	264	c.264G>A	c.(262-264)ccG>ccA	p.P88P	GJA8_uc001epu.2_Silent_p.P88P	NM_005267	NP_005258	P48165	CXA8_HUMAN	Homo sapiens gap junction protein, alpha 8, 50kDa (GJA8), mRNA.	88			P -> S (in CZP1).		cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					TCTCCACCCCGTCCCTGATGT	0.642												
LAMB3	3914	broad.mit.edu	37	1	209803992	209803992	+	Missense_Mutation	SNP	G	G	A	rs114394307	by1000genomes	TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr1:209803992G>A	uc001hhg.3	-	7	1301	c.911C>T	c.(910-912)cCg>cTg	p.P304L	LAMB3_uc009xco.3_Missense_Mutation_p.P304L|LAMB3_uc001hhh.3_Missense_Mutation_p.P304L|LAMB3_uc010psl.1_Non-coding_Transcript|LAMB3_uc009xcp.1_Missense_Mutation_p.P240L	NM_001017402	NP_001121113	Q13751	LAMB3_HUMAN	Homo sapiens laminin, beta 3 (LAMB3), transcript variant 2, mRNA.	304	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GCCCTCCGCCGGTCTCCAGGG	0.622												
RYR2	6262	broad.mit.edu	37	1	237774131	237774131	+	Missense_Mutation	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr1:237774131C>T	uc001hyl.1	+	35	4873	c.4753C>T	c.(4753-4755)Cgc>Tgc	p.R1585C		NM_001035	NP_001026	Q92736	RYR2_HUMAN	Homo sapiens ryanodine receptor 2 (cardiac) (RYR2), mRNA.	1585	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTGCCCCCCGCGCCTCCACGT	0.537												
ITIH5	80760	broad.mit.edu	37	10	7679260	7679260	+	Missense_Mutation	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr10:7679260C>T	uc021pmv.1	-	4	689	c.583G>A	c.(583-585)Gcg>Acg	p.A195T	ITIH5_uc001ijr.2_Missense_Mutation_p.A195T	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	Homo sapiens inter-alpha-trypsin inhibitor heavy chain family, member 5 (ITIH5), transcript variant 1, mRNA.	195					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity	p.A195V(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						GCGATGCCCGCGCTCTCCAGG	0.662												
C10orf54	64115	broad.mit.edu	37	10	73521395	73521395	+	Missense_Mutation	SNP	C	C	G			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr10:73521395C>G	uc001jsd.3	-	1	612	c.471G>C	c.(469-471)gaG>gaC	p.E157D	CDH23_uc001jrx.4_Intron|C10orf54_uc001jse.3_Missense_Mutation_p.E25D	NM_022153	NP_071436	Q9H7M9	GI24_HUMAN	Homo sapiens chromosome 10 open reading frame 54 (C10orf54), mRNA.	157	Ig-like.					integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	9						GGACCCTGTGCTCCGAGTGGT	0.617												
KCNQ1	3784	broad.mit.edu	37	11	2592573	2592573	+	Missense_Mutation	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:2592573C>T	uc001lwn.3	+	3	731	c.623C>T	c.(622-624)gCc>gTc	p.A208V	KCNQ1_uc009ydp.1_Intron|KCNQ1_uc001lwo.3_Missense_Mutation_p.A81V	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	Homo sapiens potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1), transcript variant 1, mRNA.	208					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	GTGGTCGTGGCCTCCATGGTG	0.652												
LDHAL6A	160287	broad.mit.edu	37	11	18487327	18487327	+	Missense_Mutation	SNP	C	C	G			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:18487327C>G	uc001mop.1	+	3	649	c.388C>G	c.(388-390)Cac>Gac	p.H130D	LDHAL6A_uc001moq.2_Missense_Mutation_p.H130D	NM_001144071	NP_659409	Q6ZMR3	LDH6A_HUMAN	Homo sapiens lactate dehydrogenase A-like 6A (LDHAL6A), transcript variant 2, mRNA.	130					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity			large_intestine(3)|lung(9)|urinary_tract(1)	13					NADH(DB00157)	GTACAGTCCTCACTGCAAACT	0.383												
ANO5	203859	broad.mit.edu	37	11	22215065	22215065	+	Silent	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:22215065G>A	uc001mqi.2	+	0	344	c.27G>A	c.(25-27)gtG>gtA	p.V9V	ANO5_uc001mqj.2_Silent_p.V9V	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	Homo sapiens anoctamin 5 (ANO5), transcript variant 1, mRNA.	9						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TCCTGGAAGTGTTGGCGGAGG	0.667												
CKAP5	9793	broad.mit.edu	37	11	46801800	46801800	+	Missense_Mutation	SNP	A	A	G			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:46801800A>G	uc001ndi.2	-	19	2503	c.2377T>C	c.(2377-2379)Ttc>Ctc	p.F793L	CKAP5_uc009ylg.1_Missense_Mutation_p.F679L|CKAP5_uc001ndj.2_Missense_Mutation_p.F793L|Metazoa_SRP_uc021qiq.1_5'Flank	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	Homo sapiens cytoskeleton associated protein 5 (CKAP5), transcript variant 1, mRNA.	793					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						TCCTCAAAGAACATTCGCAAA	0.428												
OR4C3	256144	broad.mit.edu	37	11	48346804	48346804	+	Silent	SNP	T	T	C			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:48346804T>C	uc010rhv.2	+	0	312	c.312T>C	c.(310-312)ccT>ccC	p.P104P		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily C, member 3 (OR4C3), mRNA.	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						CTATGGCTCCTAAACTCATTG	0.463												
OR10V1	390201	broad.mit.edu	37	11	59480721	59480721	+	Silent	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:59480721G>A	uc001nof.1	-	0	598	c.598C>T	c.(598-600)Ctg>Ttg	p.L200L		NM_001005324	NP_001005324	Q8NGI7	O10V1_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily V, member 1 (OR10V1), mRNA.	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|liver(1)|lung(10)|skin(1)	16						ATGATATACAGAGCAGTCTTG	0.498												
SCAF11	9169	broad.mit.edu	37	12	46320707	46320708	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr12:46320707_46320708delTC	uc001rox.3	-	10	3063_3064	c.2776_2777delGA	c.(2776-2778)gaafs	p.E926fs	SCAF11_uc001row.3_Frame_Shift_Del_p.E611fs|SCAF11_uc001roy.1_Frame_Shift_Del_p.E1000fs	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	Homo sapiens SR-related CTD-associated factor 11 (SCAF11), mRNA.	926	Arg-rich.				spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						GGTTCTCCTTTCTCTCTCTCTC	0.446												
USP15	9958	broad.mit.edu	37	12	62777954	62777954	+	Silent	SNP	T	T	C			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr12:62777954T>C	uc001src.2	+	10	1419	c.1344T>C	c.(1342-1344)tgT>tgC	p.C448C	USP15_uc001srb.2_Silent_p.C419C	NM_001252078	NP_001239007	Q9Y4E8	UBP15_HUMAN	Homo sapiens ubiquitin specific peptidase 15 (USP15), transcript variant 1, mRNA.	448					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.L447L(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		CTTTAGTTTGTCCTGAGTGTG	0.358												
CTAGE11P	647288	broad.mit.edu	37	13	75814355	75814355	+	Missense_Mutation	SNP	C	C	G			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr13:75814355C>G	uc010ths.2	-	0	163	c.122G>C	c.(121-123)tGg>tCg	p.W41S						Homo sapiens CTAGE family, member 11, pseudogene (CTAGE11P), non-coding RNA.																		CACCAGTTCCCATGGAAAACC	0.488												
ADAM21	8747	broad.mit.edu	37	14	70926319	70926319	+	Silent	SNP	C	C	T	rs142273524	byFrequency	TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr14:70926319C>T	uc021rvq.1	+	0	2103	c.2103C>T	c.(2101-2103)gtC>gtT	p.V701V	ADAM21_uc001xmd.3_Silent_p.V701V	NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	Homo sapiens ADAM metallopeptidase domain 21 (ADAM21), mRNA.	701					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TGTTTACTGTCGGGCTTCTTA	0.413												
ZDHHC1	29800	broad.mit.edu	37	16	67429021	67429021	+	Missense_Mutation	SNP	A	A	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr16:67429021A>T	uc010vjm.2	-	9	1418	c.1114T>A	c.(1114-1116)Tcg>Acg	p.S372T	TPPP3_uc002etb.3_5'Flank|TPPP3_uc002eta.3_5'Flank	NM_013304	NP_037436	Q8WTX9	ZDHC1_HUMAN	Homo sapiens zinc finger, DHHC-type containing 1 (ZDHHC1), mRNA.	372						integral to membrane	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|urinary_tract(1)	10		Ovarian(137;0.223)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0178)|all cancers(182;5.71e-53)|Epithelial(162;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(108;1.53e-29)|Kidney(780;4.37e-05)|BRCA - Breast invasive adenocarcinoma(181;5.8e-05)|GBM - Glioblastoma multiforme(240;0.0022)		AGCAGAGGCGAGCGCCAGGGT	0.622												
KRTAP3-3	85293	broad.mit.edu	37	17	39150169	39150169	+	Missense_Mutation	SNP	A	A	G			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr17:39150169A>G	uc002hvr.1	-	0	217	c.181T>C	c.(181-183)Tgc>Cgc	p.C61R		NM_033185	NP_149441	Q9BYR6	KRA33_HUMAN	Homo sapiens keratin associated protein 3-3 (KRTAP3-3), mRNA.	61						keratin filament	structural molecule activity	p.C61C(1)		lung(2)|prostate(2)	4		Breast(137;0.00043)				GTGGGCACGCAGGGCTGAGGA	0.627												
ARHGAP28	79822	broad.mit.edu	37	18	6859874	6859874	+	Missense_Mutation	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr18:6859874C>T	uc002knc.3	+	4	3759	c.548C>T	c.(547-549)gCg>gTg	p.A183V	ARHGAP28_uc002kne.3_Missense_Mutation_p.A76V|ARHGAP28_uc010wzi.2_Missense_Mutation_p.A58V|ARHGAP28_uc002knf.3_Missense_Mutation_p.A67V	NM_001010000	NP_001010000	B4DXL2	B4DXL2_HUMAN	Homo sapiens Rho GTPase activating protein 28 (ARHGAP28), mRNA.	58					signal transduction	intracellular				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	37		Colorectal(10;0.168)				GGGAGTTTTGCGGTTCCCAGG	0.433												
ABCA7	10347	broad.mit.edu	37	19	1042173	1042173	+	Missense_Mutation	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr19:1042173C>T	uc002lqw.4	+	4	644	c.413C>T	c.(412-414)aCg>aTg	p.T138M	ABCA7_uc010dsb.1_5'Flank|ABCA7_uc010dsa.3_Missense_Mutation_p.T138M	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 7 (ABCA7), mRNA.	138					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACGCAGCACGGGTGAGGAG	0.692												
ZNF833P	401898	broad.mit.edu	37	19	11795746	11795746	+	Translation_Start_Site	SNP	C	C	G			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr19:11795746C>G	uc021upi.1	+	2					ZNF833P_uc002msl.4_Non-coding_Transcript					Homo sapiens zinc finger protein 833, pseudogene (ZNF833P), non-coding RNA.											endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	5						GTGAAGAGATCTTCAGCCTTG	0.393												
ZNF833P	401898	broad.mit.edu	37	19	11796182	11796182	+	Silent	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr19:11796182C>T	uc021upi.1	+	2	798	c.122C>T	c.(121-123)tCa>tTa	p.S41L	ZNF833P_uc002msl.4_Non-coding_Transcript					Homo sapiens zinc finger protein 833, pseudogene (ZNF833P), non-coding RNA.											endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	5						GGAAAGCCTTCAGTTGTTCCA	0.368												
PPM1N	147699	broad.mit.edu	37	19	46003206	46003206	+	Splice_Site	SNP	G	G	C			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr19:46003206G>C	uc002pce.3	+	2	940	c.940_splice	c.e2-1	p.G314_splice	RTN2_uc002pcb.3_5'Flank|RTN2_uc002pcc.3_5'Flank|RTN2_uc002pcd.3_5'Flank|PPM1N_uc002pcf.3_Splice_Site	NM_001080401	NP_001073870	Q8N819	PPM1N_HUMAN	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) (PPM1N), mRNA.	314	PP2C-like.						magnesium ion binding|manganese ion binding|phosphoprotein phosphatase activity			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)	9						ACCGGCTTCAGGGCAGCCTGG	0.607												
ZSCAN5B	342933	broad.mit.edu	37	19	56701423	56701423	+	Missense_Mutation	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr19:56701423C>T	uc010ygh.2	-	3	1261	c.1261G>A	c.(1261-1263)Gcc>Acc	p.A421T		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	Homo sapiens zinc finger and SCAN domain containing 5B (ZSCAN5B), mRNA.	421					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						GACTCGTGGGCGAACCGCTTT	0.567												
CAD	790	broad.mit.edu	37	2	27465785	27465785	+	Missense_Mutation	SNP	C	C	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr2:27465785C>A	uc002rji.3	+	41	6586	c.6424C>A	c.(6424-6426)Ctc>Atc	p.L2142I	CAD_uc010eyw.3_Missense_Mutation_p.L2079I	NM_004341	NP_004332	P27708	PYR1_HUMAN	Homo sapiens carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), mRNA.	2142	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CACTGATGTGCTCTACATGAC	0.582												
PRKD3	23683	broad.mit.edu	37	2	37501816	37501816	+	Missense_Mutation	SNP	G	G	C			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr2:37501816G>C	uc002rqd.3	-	9	1954	c.1399C>G	c.(1399-1401)Cgc>Ggc	p.R467G	PRKD3_uc002rqe.1_Missense_Mutation_p.R67G|PRKD3_uc002rqf.1_Missense_Mutation_p.R467G	NM_005813	NP_005804	O94806	KPCD3_HUMAN	Homo sapiens protein kinase D3 (PRKD3), mRNA.	467	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				GAAGATATGCGGAGAATTTCT	0.318												
ST6GAL2	84620	broad.mit.edu	37	2	107460204	107460204	+	Missense_Mutation	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr2:107460204C>T	uc002tdq.3	-	1	349	c.230G>A	c.(229-231)cGc>cAc	p.R77H	ST6GAL2_uc002tdr.3_Missense_Mutation_p.R77H|ST6GAL2_uc002tds.3_Missense_Mutation_p.R77H	NM_001142351	NP_115917	Q96JF0	SIAT2_HUMAN	Homo sapiens ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 (ST6GAL2), transcript variant 2, mRNA.	77					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CAGCGCCTGGCGTGCGTCCAG	0.677												
PPIG	9360	broad.mit.edu	37	2	170493100	170493100	+	Missense_Mutation	SNP	A	A	C			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr2:170493100A>C	uc002uez.3	+	13	1552	c.1332A>C	c.(1330-1332)aaA>aaC	p.K444N	PPIG_uc010fpx.3_Missense_Mutation_p.K429N|PPIG_uc010fpy.3_Missense_Mutation_p.K437N|PPIG_uc002ufb.3_Missense_Mutation_p.K444N|PPIG_uc002ufd.3_Missense_Mutation_p.K441N	NM_004792	NP_004783	Q13427	PPIG_HUMAN	Homo sapiens peptidylprolyl isomerase G (cyclophilin G) (PPIG), mRNA.	444					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	ATTCAGAAAAAGATGACAAGT	0.313												
KRTAP19-2	337969	broad.mit.edu	37	21	31859635	31859635	+	Missense_Mutation	SNP	G	G	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr21:31859635G>T	uc011acy.2	-	0	33	c.33C>A	c.(31-33)agC>agA	p.S11R		NM_181608	NP_853639	Q3LHN2	KR192_HUMAN	Homo sapiens keratin associated protein 19-2 (KRTAP19-2), mRNA.	11						intermediate filament		p.G10S(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						GTCTGCAGAAGCTGCCACATC	0.572												
TMPRSS3	64699	broad.mit.edu	37	21	43803237	43803237	+	Silent	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr21:43803237G>A	uc002zbb.2	-	7	888	c.687C>T	c.(685-687)ccC>ccT	p.P229P	TMPRSS3_uc002zay.2_5'UTR|TMPRSS3_uc002zaz.2_Silent_p.P102P|TMPRSS3_uc002zba.2_Silent_p.P102P|TMPRSS3_uc002zbc.2_Silent_p.P229P|TMPRSS3_uc002zbd.3_Silent_p.P229P	NM_024022	NP_076927	P57727	TMPS3_HUMAN	Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant A, mRNA.	229	Peptidase S1.				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(4)|skin(1)	13						TGGCCTGCCAGGGCCACTGCG	0.587												
C22orf43	51233	broad.mit.edu	37	22	23959767	23959769	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr22:23959767_23959769delCAT	uc002zxf.3	-	6	810_812	c.512_514delATG	c.(511-516)gatgcc>gcc	p.D171del		NM_016449	NP_057533	Q6PGQ1	CV043_HUMAN	Homo sapiens chromosome 22 open reading frame 43 (C22orf43), mRNA.	171	Asp-rich.									endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)	11						CTTACCTGGGcatcatcatcatc	0.433												
C22orf24	25775	broad.mit.edu	37	22	32334001	32334001	+	Missense_Mutation	SNP	T	T	C			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr22:32334001T>C	uc003aly.3	-	1	219	c.52A>G	c.(52-54)Acc>Gcc	p.T18A	C22orf24_uc003alx.3_Non-coding_Transcript	NM_015372	NP_056187	Q9Y442	CV024_HUMAN	Homo sapiens chromosome 22 open reading frame 24 (C22orf24), mRNA.	18						integral to membrane				central_nervous_system(1)|urinary_tract(1)	2						CTTGACATGGTCCAAAGACTT	0.473												
C3orf20	84077	broad.mit.edu	37	3	14802983	14802983	+	Missense_Mutation	SNP	T	T	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr3:14802983T>A	uc003byy.3	+	14	2808	c.2356T>A	c.(2356-2358)Ttt>Att	p.F786I	C3orf20_uc003byz.3_Missense_Mutation_p.F664I|C3orf20_uc003bza.3_Missense_Mutation_p.F664I|C3orf20_uc003bzb.1_Missense_Mutation_p.F287I|C3orf20_uc011avj.2_Missense_Mutation_p.F113I	NM_032137	NP_001171887	Q8ND61	CC020_HUMAN	Homo sapiens chromosome 3 open reading frame 20 (C3orf20), transcript variant 1, mRNA.	786						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						TCAACAGATGTTTGCCGGGGG	0.483												
NR2C2	7182	broad.mit.edu	37	3	15079601	15079601	+	Silent	SNP	C	C	G			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr3:15079601C>G	uc003bzj.4	+	11	1684	c.1467C>G	c.(1465-1467)ggC>ggG	p.G489G	NR2C2_uc003bzi.3_Silent_p.G508G	NM_003298	NP_003289	P49116	NR2C2_HUMAN	Homo sapiens nuclear receptor subfamily 2, group C, member 2 (NR2C2), mRNA.	489	Ligand-binding (By similarity).				cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(5)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						ATATAGATGGCTATGAGTATG	0.453												
HSPBAP1	79663	broad.mit.edu	37	3	122459942	122459942	+	Missense_Mutation	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr3:122459942G>A	uc003efu.2	-	6	983	c.844C>T	c.(844-846)Cgg>Tgg	p.R282W	HSPBAP1_uc003eft.2_5'UTR	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Homo sapiens HSPB (heat shock 27kDa) associated protein 1 (HSPBAP1), mRNA.	282	JmjC.					cytoplasm		p.R282L(2)		breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|urinary_tract(1)	16				GBM - Glioblastoma multiforme(114;0.0531)		TCTTCTACCCGGGCTAGGTGA	0.423												
SLIT2	9353	broad.mit.edu	37	4	20541195	20541195	+	Missense_Mutation	SNP	C	C	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr4:20541195C>A	uc003gpr.1	+	18	2168	c.1964C>A	c.(1963-1965)tCt>tAt	p.S655Y	SLIT2_uc003gps.1_Missense_Mutation_p.S647Y	NM_004787	NP_004778	O94813	SLIT2_HUMAN	Homo sapiens slit homolog 2 (Drosophila) (SLIT2), mRNA.	655					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						ACTCTCCATTCTTTATCTACT	0.308												
BANK1	55024	broad.mit.edu	37	4	102946614	102946614	+	Silent	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr4:102946614G>A	uc003hvy.4	+	8	1816	c.1542G>A	c.(1540-1542)ccG>ccA	p.P514P	BANK1_uc003hvx.4_Silent_p.P499P|BANK1_uc010ill.3_Silent_p.P381P|BANK1_uc003hvz.4_Silent_p.P484P	NM_017935	NP_001077376	Q8NDB2	BANK1_HUMAN	Homo sapiens B-cell scaffold protein with ankyrin repeats 1 (BANK1), transcript variant 1, mRNA.	514					B cell activation			p.P514L(1)		NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		TCCCCCCGCCGCGACCTGTAG	0.433												
ALPK1	80216	broad.mit.edu	37	4	113353098	113353098	+	Frame_Shift_Del	DEL	C	C	-			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr4:113353098delC	uc003ian.4	+	10	2622	c.2395delC	c.(2395-2397)cccfs	p.P799fs	ALPK1_uc003iap.4_Frame_Shift_Del_p.P799fs|ALPK1_uc011cfx.2_Frame_Shift_Del_p.P721fs|ALPK1_uc003iao.4_Intron|ALPK1_uc010imo.3_Frame_Shift_Del_p.P627fs	NM_001102406	NP_079420	Q96QP1	ALPK1_HUMAN	Homo sapiens alpha-kinase 1 (ALPK1), transcript variant 2, mRNA.	799							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TGAAGATGCACCCTTAGACTT	0.488												
FHDC1	85462	broad.mit.edu	37	4	153897835	153897835	+	Missense_Mutation	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr4:153897835G>A	uc003inf.2	+	10	3467	c.3392G>A	c.(3391-3393)cGg>cAg	p.R1131Q		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	Homo sapiens FH2 domain containing 1 (FHDC1), mRNA.	1131					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GACTCCAGTCGGACCACGCTG	0.637												
POU4F3	5459	broad.mit.edu	37	5	145719603	145719603	+	Missense_Mutation	SNP	C	C	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr5:145719603C>A	uc003loa.2	+	1	702	c.613C>A	c.(613-615)Cag>Aag	p.Q205K		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	Homo sapiens POU class 4 homeobox 3 (POU4F3), mRNA.	205	POU-specific.				sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.Q205H(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGGGTGACCCAGGCGGACGT	0.657												
HIST1H2AA	221613	broad.mit.edu	37	6	25726720	25726720	+	Silent	SNP	G	G	A	rs150563946	byFrequency	TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr6:25726720G>A	uc003nfc.3	-	0	71	c.36C>T	c.(34-36)cgC>cgT	p.R12R	HIST1H2BA_uc003nfd.3_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	Homo sapiens histone cluster 1, H2aa (HIST1H2AA), mRNA.	12					nucleosome assembly	nucleosome|nucleus	DNA binding	p.R12P(1)		breast(1)|endometrium(2)|large_intestine(2)|lung(8)	13						TAGACTTGGCGCGTGCTTTTC	0.532												
BTN3A3	10384	broad.mit.edu	37	6	26452287	26452287	+	Missense_Mutation	SNP	A	A	G			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr6:26452287A>G	uc003nhz.3	+	10	1646	c.1403A>G	c.(1402-1404)gAg>gGg	p.E468G	BTN3A3_uc011dkn.2_Missense_Mutation_p.E419G|BTN3A3_uc021ynh.1_Missense_Mutation_p.E258G	NM_006994	NP_008925	O00478	BT3A3_HUMAN	Homo sapiens butyrophilin, subfamily 3, member A3 (BTN3A3), transcript variant 1, mRNA.	468	B30.2/SPRY.					integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						CTGGACTATGAGACTGGAGAG	0.483												
EEF1A1	1915	broad.mit.edu	37	6	74229196	74229196	+	Missense_Mutation	SNP	A	A	C			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr6:74229196A>C	uc003phi.3	-	1	1180	c.188T>G	c.(187-189)cTg>cGg	p.L63R	EEF1A1_uc003phj.3_Missense_Mutation_p.L63R|EEF1A1_uc021zbs.1_Non-coding_Transcript|EEF1A1_uc003phl.3_Missense_Mutation_p.L63R|EEF1A1_uc003phm.1_Intron|EEF1A1_uc021zbt.1_5'Flank|EEF1A1_uc021zbu.1_5'Flank	NM_001402	NP_001393	P68104	EF1A1_HUMAN	Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), mRNA.	63						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(6)|prostate(2)|skin(3)	18						CTCAGCTTTCAGTTTATCCAA	0.428											OREG0003890	type=REGULATORY REGION|Gene=LOC477388|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay
IQCE	23288	broad.mit.edu	37	7	2611279	2611279	+	Missense_Mutation	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr7:2611279G>A	uc003sml.1	+	3	434	c.250G>A	c.(250-252)Gca>Aca	p.A84T	IQCE_uc010ksm.1_Missense_Mutation_p.A84T|IQCE_uc011jvy.1_Missense_Mutation_p.A68T|IQCE_uc011jvz.1_Missense_Mutation_p.A19T|IQCE_uc003smo.4_Missense_Mutation_p.A84T|IQCE_uc003smk.4_Missense_Mutation_p.A68T|IQCE_uc003smn.4_Missense_Mutation_p.A19T	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	Homo sapiens IQ motif containing E (IQCE), transcript variant 1, mRNA.	84										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		GCTGGGAACCGCAAAGCCAGG	0.572												
FAM183B	340286	broad.mit.edu	37	7	38725660	38725660	+	Nonsense_Mutation	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr7:38725660G>A	uc011kbd.2	-	1	933	c.637C>T	c.(637-639)Cga>Tga	p.R213*						Homo sapiens family with sequence similarity 183, member B (FAM183B), non-coding RNA.											endometrium(1)|lung(7)	8						CTTACCACTCGCTTGGCTGCG	0.632												
EGFR	1956	broad.mit.edu	37	7	55221822	55221822	+	Missense_Mutation	SNP	C	C	T	rs149840192		TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr7:55221822C>T	uc003tqk.3	+	6	1112	c.866C>T	c.(865-867)gCc>gTc	p.A289V	EGFR_uc003tqh.3_Missense_Mutation_p.A289V|EGFR_uc003tqi.3_Missense_Mutation_p.A289V|EGFR_uc003tqj.3_Missense_Mutation_p.A289V|EGFR_uc022adm.1_Missense_Mutation_p.A289V|EGFR_uc010kzg.2_Missense_Mutation_p.A244V|EGFR_uc022adn.1_Missense_Mutation_p.A244V|EGFR_uc011kco.2_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.	289					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(40)|p.A289D(6)|p.V30_R297>G(5)|p.A289T(3)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)		
HBP1	26959	broad.mit.edu	37	7	106829793	106829793	+	Silent	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr7:106829793C>T	uc003vdy.3	+	6	1008	c.822C>T	c.(820-822)ggC>ggT	p.G274G	HBP1_uc011klv.2_Silent_p.G284G|HBP1_uc003vdz.3_Silent_p.G274G|HBP1_uc003vea.3_Silent_p.G274G|HBP1_uc003veb.1_Silent_p.G274G	NM_012257	NP_036389	O60381	HBP1_HUMAN	Homo sapiens HMG-box transcription factor 1 (HBP1), transcript variant 2, mRNA.	274	AXH.				cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			large_intestine(4)|lung(3)|prostate(1)|skin(2)	10						TATCATTTGGCGAGTCTGTAC	0.368												
SLC30A8	169026	broad.mit.edu	37	8	118170045	118170045	+	Missense_Mutation	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr8:118170045G>A	uc003yoh.3	+	3	764	c.534G>A	c.(532-534)atG>atA	p.M178I	SLC30A8_uc010mcz.3_Missense_Mutation_p.M129I|SLC30A8_uc003yog.3_Missense_Mutation_p.M129I|SLC30A8_uc011lia.2_Missense_Mutation_p.M129I|SLC30A8_uc022bab.1_Missense_Mutation_p.M129I	NM_173851	NP_001166286	Q8IWU4	ZNT8_HUMAN	Homo sapiens solute carrier family 30 (zinc transporter), member 8 (SLC30A8), transcript variant 1, mRNA.	178					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			CGACTGTGATGATCATCGTTT	0.547												
TONSL	4796	broad.mit.edu	37	8	145662013	145662013	+	Missense_Mutation	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr8:145662013C>T	uc011llg.2	-	15	1957	c.1942G>A	c.(1942-1944)Gac>Aac	p.D648N	AK298596_uc011llh.1_Intron	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	Homo sapiens tonsoku-like, DNA repair protein (TONSL), mRNA.	648					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity			biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						AGGTCCAGGTCCCTGCGGTAC	0.682												
ABO	28	broad.mit.edu	37	9	136136731	136136731	+	Missense_Mutation	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr9:136136731G>A	uc004cda.1	-	2	170	c.145C>T	c.(145-147)Cgg>Tgg	p.R49W	ABO_uc010naf.1_5'UTR|ABO_uc011mcz.1_5'UTR|ABO_uc010nag.1_Intron	NM_020469	NP_065202	P16442	BGAT_HUMAN	Homo sapiens ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) (ABO), mRNA.	49					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		CAGAACCCCCGTTCCAGGCTT	0.607												
NLGN4X	57502	broad.mit.edu	37	X	5811156	5811156	+	Missense_Mutation	SNP	G	G	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:5811156G>T	uc010ndi.3	-	6	2728	c.2264C>A	c.(2263-2265)aCa>aAa	p.T755K	NLGN4X_uc004crp.3_Missense_Mutation_p.T738K|NLGN4X_uc010ndh.3_Missense_Mutation_p.T718K|NLGN4X_uc004crq.3_Missense_Mutation_p.T718K|NLGN4X_uc004crr.3_Missense_Mutation_p.T718K|NLGN4X_uc010ndj.3_Missense_Mutation_p.T718K	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	Homo sapiens neuroligin 4, X-linked (NLGN4X), transcript variant 2, mRNA.	718					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						GATATCATTTGTGGTGTTTCT	0.522												
SSX3	10214	broad.mit.edu	37	X	48209558	48209558	+	Splice_Site	SNP	C	C	T			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:48209558C>T	uc004djd.1	-	6	425	c.331_splice	c.e6-1	p.I111_splice	SSX3_uc004dje.3_Splice_Site_p.I111_splice	NM_021014	NP_066294	Q99909	SSX3_HUMAN	Homo sapiens synovial sarcoma, X breakpoint 3 (SSX3), transcript variant 1, mRNA.	111					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|large_intestine(1)|lung(9)	13						TGGGCATGATCTTTATAATGT	0.433												
KCND1	3750	broad.mit.edu	37	X	48822565	48822565	+	Missense_Mutation	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:48822565G>A	uc004dlx.1	-	4	3188	c.1615C>T	c.(1615-1617)Cgc>Tgc	p.R539C	KCND1_uc004dlw.1_Missense_Mutation_p.R162C	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	Homo sapiens potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), mRNA.	539						voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	24						ATGGCGCGGCGCTTGGCCCTG	0.682												
KIAA1210	57481	broad.mit.edu	37	X	118222577	118222577	+	Silent	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:118222577G>A	uc004era.4	-	10	2616	c.2616C>T	c.(2614-2616)gaC>gaT	p.D872D		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	Homo sapiens KIAA1210 (KIAA1210), mRNA.	872										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TGAGAGGCAGGTCTTCCTCTG	0.448												
MAGEC2	51438	broad.mit.edu	37	X	141291256	141291256	+	Missense_Mutation	SNP	T	T	G			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:141291256T>G	uc022cfj.1	-	0	518	c.518A>C	c.(517-519)aAg>aCg	p.K173T	MAGEC2_uc004fbu.2_Missense_Mutation_p.K173T	NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	Homo sapiens melanoma antigen family C, 2 (MAGEC2), mRNA.	173	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					ATCTTTGTACTTGATGACAAT	0.478										HNSCC(46;0.14)		
MAGEA6	4105	broad.mit.edu	37	X	151870086	151870086	+	Missense_Mutation	SNP	G	G	A			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:151870086G>A	uc022chf.1	+	0	776	c.776G>A	c.(775-777)cGg>cAg	p.R259Q	MAGEA6_uc004ffq.1_Missense_Mutation_p.R259Q|MAGEA6_uc004ffr.1_Missense_Mutation_p.R259Q	NM_175868	NP_787064	P43360	MAGA6_HUMAN	Homo sapiens melanoma antigen family A, 6 (MAGEA6), transcript variant 2, mRNA.	259	MAGE.						protein binding	p.R259Q(2)|p.R259R(1)		breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					CTGGAGTACCGGCAGGTCCCC	0.522												
