Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RFWD2	64326	broad.mit.edu	37	1	176132079	176132079	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr1:176132079G>A	ENST00000367669.3	-	5	1202	c.688C>T	c.(688-690)Caa>Taa	p.Q230*	RFWD2_ENST00000308769.8_Nonsense_Mutation_p.Q226*	NM_022457.5	NP_071902.2	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	230					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						AGGTTATCTTGGTCAGTTCCC	0.368000													8	70					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66765161	66765161	+	Missense_Mutation	SNP	A	A	T	rs71905623		TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chrX:66765161A>T	ENST00000374690.3	+	1	697	c.173A>T	c.(172-174)cAg>cTg	p.Q58L	AR_ENST00000513847.1_3'UTR|AR_ENST00000396044.3_Missense_Mutation_p.Q58L|AR_ENST00000504326.1_Missense_Mutation_p.Q58L	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	58	Gln-rich.|Modulating.|Poly-Gln.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding	p.Q58L(2)		breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CTGCTGCTgcagcagcagcag	0.667000									Androgen Insensitivity Syndrome				3	34					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23532675	23532675	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr14:23532675G>A	ENST00000262710.1	-	13	3208	c.2881C>T	c.(2881-2883)Ccc>Tcc	p.P961S	ACIN1_ENST00000555053.1_Missense_Mutation_p.P948S|ACIN1_ENST00000457657.1_Missense_Mutation_p.P921S|ACIN1_ENST00000557515.1_Missense_Mutation_p.P202S|ACIN1_ENST00000397341.3_Missense_Mutation_p.P203S|ACIN1_ENST00000357481.2_Missense_Mutation_p.P203S|ACIN1_ENST00000338631.6_Missense_Mutation_p.P234S|ACIN1_ENST00000605057.1_Missense_Mutation_p.P903S	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	961					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GCAGGTGGGGGCAAGGCCACC	0.517000													3	58					0	0	1	0	0
SEC14L3	266629	broad.mit.edu	37	22	30858119	30858119	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr22:30858119C>A	ENST00000403066.1	-	10	831	c.548G>T	c.(547-549)gGg>gTg	p.G183V	SEC14L3_ENST00000415957.2_Missense_Mutation_p.G183V|SEC14L3_ENST00000402286.1_Missense_Mutation_p.G165V|SEC14L3_ENST00000401751.1_Missense_Mutation_p.G183V|SEC14L3_ENST00000215812.4_Missense_Mutation_p.G242V|SEC14L3_ENST00000540910.1_Missense_Mutation_p.G165V|SEC14L3_ENST00000539629.1_Missense_Mutation_p.G183V			Q9UDX4	S14L3_HUMAN	SEC14-like 3 (S. cerevisiae)	242	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	19					Vitamin E(DB00163)	CAGGGTGCCCCCAAACTGGGC	0.517000													3	32					0.00024832	0.000275911	1	1	0
TRIM51HP	0	broad.mit.edu	37	11	55065601	55065601	+	RNA	SNP	C	C	G	rs4100282		TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr11:55065601C>G	ENST00000526016.1	-	0	107					NR_038174.2																						CACTGAGCAACAACTGCCATG	0.488000													4	36					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53945909	53945909	+	RNA	SNP	T	T	C	rs28727441	by1000genomes	TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr19:53945909T>C	ENST00000454407.1	+	0	55				TPM3P9_ENST00000424846.3_RNA			Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		ACCCTGACTCTGCCTGAGGCC	0.562000													3	44					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625955	29625955	+	Nonsense_Mutation	SNP	A	A	T			TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr20:29625955A>T	ENST00000278882.3	+	5	579	c.199A>T	c.(199-201)Aga>Tga	p.R67*	FRG1B_ENST00000439954.2_Nonsense_Mutation_p.R72*|FRG1B_ENST00000358464.4_Nonsense_Mutation_p.R67*																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATTGGACCAAGAGAACAATG	0.338000													6	84					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													5	86					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115524063	115524063	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr1:115524063G>A	ENST00000369522.3	+	29	2729	c.2489G>A	c.(2488-2490)gGc>gAc	p.G830D	SYCP1_ENST00000477590.1_3'UTR|SYCP1_ENST00000369518.1_Missense_Mutation_p.G830D	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	830					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTTGATCATGGCATATCCAAA	0.333000													4	82					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81112720	81112720	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr12:81112720C>T	ENST00000228644.3	+	3	810	c.658C>T	c.(658-660)Cct>Tct	p.P220S		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	220					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						CTCAGAGCAACCTGGGTTGCC	0.488000													14	71					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101667847	101667847	+	Missense_Mutation	SNP	G	G	A	rs114927649	byFrequency	TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr10:101667847G>A	ENST00000342239.3	-	6	2550	c.2459C>T	c.(2458-2460)cCa>cTa	p.P820L	DNMBP_ENST00000324109.4_Missense_Mutation_p.P820L|DNMBP_ENST00000543621.1_Missense_Mutation_p.P66L			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	820	DH.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		ATCAATGTTTGGTACCTGAGA	0.368000													3	35					0	0	1	0	0
KRT16P2	0	broad.mit.edu	37	17	16734855	16734855	+	RNA	SNP	C	C	T	rs688852	by1000genomes	TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr17:16734855C>T	ENST00000579062.1	-	0	460																		p.R183Q(1)									CACAGTCTGCCGCAGGGCCAG	0.632000													3	15					0	0	1	0	0
MST1L	0	broad.mit.edu	37	1	17084791	17084791	+	RNA	DEL	A	A	-			TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr1:17084791delA	ENST00000455405.2	-	0	228																											GGCCCTGCCTAGAGGAGTGGG	0.582													5	7	---	---	---	---					
AC007255.7	0	broad.mit.edu	37	7	29720482	29720483	+	RNA	INS	-	-	G	rs70980562		TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr7:29720482_29720483insG	ENST00000426767.1	-	0	366					NR_024278.1																						CTCTCAGATCAGTGATGCCCTG	0.485													7	45	---	---	---	---					
RP4-777D9.2	0	broad.mit.edu	37	20	21142454	21142455	+	RNA	INS	-	-	C	rs45603533	by1000genomes	TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr20:21142454_21142455insC	ENST00000591761.1	-	0	5142				RP5-872K7.7_ENST00000425746.2_RNA|PLK1S1_ENST00000457464.1_RNA																							AAAAAAAAAAACCCCACCTAAT	0.376													9	15	---	---	---	---					
CTCFL	140690	broad.mit.edu	37	20	56099187	56099187	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DU-6406-01A-11D-1705-08	TCGA-DU-6406-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17569950-b826-4112-bf60-5a82c88a345a	3029907d-e2f8-42c8-a7bd-56c8d3fa319e	g.chr20:56099187delT	ENST00000426658.2	-	1	736	c.75delA	c.(73-75)aafs	p.K25fs	CTCFL_ENST00000502686.2_Intron|CTCFL_ENST00000429804.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000243914.3_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000433949.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000432255.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000423479.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000422869.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000422109.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000371196.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000539382.1_Intron			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	25					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CCTTCAGGCCTTTTTCCGGCA	0.502													8	685	---	---	---	---					
