Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR2L3	391192	broad.mit.edu	37	1	248224375	248224375	+	Missense_Mutation	SNP	A	A	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr1:248224375A>T	ENST00000359959.3	+	1	392	c.392A>T	c.(391-393)tAt>tTt	p.Y131F	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	131					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CCTCTTCACTATCCCATCCGC	0.433000													38	190					0	0	1	0	0
MYO6	4646	broad.mit.edu	37	6	76599795	76599795	+	Missense_Mutation	SNP	C	C	G			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr6:76599795C>G	ENST00000369981.3	+	26	2959	c.2680C>G	c.(2680-2682)Caa>Gaa	p.Q894E	MYO6_ENST00000369985.4_Missense_Mutation_p.Q894E|MYO6_ENST00000369975.1_Missense_Mutation_p.Q894E|MYO6_ENST00000369977.3_Missense_Mutation_p.Q894E			Q9UM54	MYO6_HUMAN	myosin VI	894					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GACGCAGGAACAAATCCAGAA	0.353000													7	96					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908727	103908727	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr11:103908727C>T	ENST00000302259.3	+	1	1420	c.1177C>T	c.(1177-1179)Cga>Tga	p.R393*	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	393					proteolysis		aspartic-type endopeptidase activity	p.R393*(2)		central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GGATTCAGGACGAAAAGAGCA	0.428000													5	18					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57422571	57422571	+	Missense_Mutation	SNP	C	C	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr12:57422571C>A	ENST00000442789.2	-	29	3387	c.3100G>T	c.(3100-3102)Ggg>Tgg	p.G1034W	MYO1A_ENST00000544473.1_Missense_Mutation_p.G872W|MYO1A_ENST00000300119.3_Missense_Mutation_p.G1034W|TAC3_ENST00000415231.1_5'UTR	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	1034					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						CAATGACTCCCCTTTTTTTTG	0.562000													16	119					4.7546e-09	5.12034e-09	1	1	0
ZNF473	25888	broad.mit.edu	37	19	50548736	50548736	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr19:50548736C>T	ENST00000595661.1	+	6	1531	c.1036C>T	c.(1036-1038)Cgc>Tgc	p.R346C	ZNF473_ENST00000391821.2_Missense_Mutation_p.R346C|CTD-2126E3.3_ENST00000599410.1_RNA|CTD-2126E3.3_ENST00000599914.1_RNA|ZNF473_ENST00000270617.3_Missense_Mutation_p.R346C|ZNF473_ENST00000601364.1_Intron|ZNF473_ENST00000445728.3_Missense_Mutation_p.R334C			Q8WTR7	ZN473_HUMAN	zinc finger protein 473	346	Interaction with SLBP/pre-mRNA complex.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		CACTCGGAAACGCTATGAGTG	0.478000													10	53					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38187124	38187124	+	Silent	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr8:38187124G>A	ENST00000317025.8	-	6	1870	c.1353C>T	c.(1351-1353)agC>agT	p.S451S	WHSC1L1_ENST00000527502.1_Silent_p.S451S|WHSC1L1_ENST00000316985.3_Silent_p.S451S|WHSC1L1_ENST00000433384.2_Silent_p.S451S	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	451					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			GCCGCCTCTGGCTATGTCTCC	0.522000			T	NUP98	AML								21	97					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96163694	96163694	+	Missense_Mutation	SNP	A	A	G			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr4:96163694A>G	ENST00000453304.1	-	7	1342	c.994T>C	c.(994-996)Tgc>Cgc	p.C332R	UNC5C_ENST00000506749.1_Missense_Mutation_p.C332R	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	332	TSP type-1 2.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CAGTGGGTGCACTCAGTTCCA	0.592000													7	28					0	0	1	0	0
GAS7	8522	broad.mit.edu	37	17	9837515	9837515	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr17:9837515C>T	ENST00000396115.1	-	9	983	c.673G>A	c.(673-675)Gaa>Aaa	p.E225K	GAS7_ENST00000542249.1_Missense_Mutation_p.E230K|GAS7_ENST00000540214.1_Intron|GAS7_ENST00000579158.1_Missense_Mutation_p.E237K|GAS7_ENST00000583882.1_Intron|GAS7_ENST00000580865.1_Missense_Mutation_p.E145K|GAS7_ENST00000323816.4_Missense_Mutation_p.E221K|GAS7_ENST00000585266.1_Missense_Mutation_p.E221K|GAS7_ENST00000437099.2_Missense_Mutation_p.E221K|GAS7_ENST00000432992.2_Missense_Mutation_p.E285K	NM_201432.1	NP_958836.1	O60861	GAS7_HUMAN	growth arrest-specific 7	285	FCH.				cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(7)|lung(18)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	39						ACTTCTGCTTCGTCCGCCAGG	0.537000			T	MLL	AML*								11	43					0	0	1	0	0
CAMK2A	815	broad.mit.edu	37	5	149636365	149636365	+	Missense_Mutation	SNP	A	A	G			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr5:149636365A>G	ENST00000348628.6	-	5	967	c.302T>C	c.(301-303)aTc>aCc	p.I101T	CAMK2A_ENST00000398376.3_Missense_Mutation_p.I101T	NM_015981.3|NM_171825.2	NP_057065.2|NP_741960.1	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II alpha	101	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)	15		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCGGGCCACGATATCTTCAAA	0.592000													9	28					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33145197	33145197	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr6:33145197C>T	ENST00000341947.2	-	23	2190	c.1963G>A	c.(1963-1965)Ggg>Agg	p.G655R	COL11A2_ENST00000477772.1_5'UTR|COL11A2_ENST00000374713.1_Missense_Mutation_p.G608R|COL11A2_ENST00000357486.1_Missense_Mutation_p.G634R|COL11A2_ENST00000395197.1_Missense_Mutation_p.G595R|COL11A2_ENST00000361917.1_Missense_Mutation_p.G548R|COL11A2_ENST00000374714.1_Missense_Mutation_p.G629R|COL11A2_ENST00000374708.4_Missense_Mutation_p.G569R|COL11A2_ENST00000374712.1_Missense_Mutation_p.G574R	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	655	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						ACCTGGGTCCCAGGGGTGCCC	0.552000													8	35					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9248214	9248214	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr12:9248214C>T	ENST00000318602.7	-	16	2241	c.1934G>A	c.(1933-1935)cGt>cAt	p.R645H		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	645					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	GACATTATGACGATTGATGCA	0.398000													4	59					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87183144	87183144	+	Missense_Mutation	SNP	G	G	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr7:87183144G>T	ENST00000265724.3	-	10	1349	c.932C>A	c.(931-933)gCt>gAt	p.A311D	ABCB1_ENST00000543898.1_Missense_Mutation_p.A247D	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	311	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GAAGGCCAGAGCATAAGATGC	0.383000													25	128					7.92952e-12	8.73138e-12	1	1	0
MNDA	4332	broad.mit.edu	37	1	158815468	158815468	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr1:158815468C>T	ENST00000368141.4	+	5	923	c.662C>T	c.(661-663)gCg>gTg	p.A221V		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	221	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					AAAGCAACAGCGCCATTTAAA	0.468000													8	44					0	0	1	0	0
BMP3	651	broad.mit.edu	37	4	81967316	81967316	+	Silent	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr4:81967316C>T	ENST00000282701.2	+	2	1061	c.741C>T	c.(739-741)gcC>gcT	p.A247A		NM_001201.2	NP_001192.2	P12645	BMP3_HUMAN	bone morphogenetic protein 3	247					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	29						CCAATGATGCCGCCATTTCTG	0.483000													20	87					0	0	1	0	0
ZNF777	27153	broad.mit.edu	37	7	149152540	149152540	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr7:149152540C>T	ENST00000247930.4	-	2	897	c.574G>A	c.(574-576)Gtc>Atc	p.V192I		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			ACTGCTTGGACGGCAGCCCAC	0.587000													23	116					0	0	1	0	0
FGF14	2259	broad.mit.edu	37	13	102375254	102375254	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr13:102375254G>A	ENST00000376131.4	-	5	781	c.686C>T	c.(685-687)aCg>aTg	p.T229M	ITGBL1_ENST00000415285.1_3'UTR|FGF14_ENST00000376143.4_Missense_Mutation_p.T224M	NM_175929.2	NP_787125.1	Q92915	FGF14_HUMAN	fibroblast growth factor 14	224					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding	p.T224M(1)|p.T229M(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)	29	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTTACTTGGCGTCACCCCAGG	0.473000													10	76					0	0	1	0	0
FES	2242	broad.mit.edu	37	15	91436545	91436545	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr15:91436545G>A	ENST00000328850.3	+	16	2088	c.1946G>A	c.(1945-1947)cGc>cAc	p.R649H	FES_ENST00000444422.2_Missense_Mutation_p.R579H|FES_ENST00000414248.2_Missense_Mutation_p.R521H|FES_ENST00000450438.2_Missense_Mutation_p.R521H|FES_ENST00000394300.3_Missense_Mutation_p.R591H|FES_ENST00000394302.1_Missense_Mutation_p.R508H	NM_002005.3	NP_001996.1	P07332	FES_HUMAN	feline sarcoma oncogene	649	Protein kinase.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			ACCTTCCTCCGCACGGAGGGG	0.672000													5	25					0	0	1	0	0
MS4A6A	64231	broad.mit.edu	37	11	59949075	59949075	+	Silent	SNP	G	G	A	rs113133013		TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr11:59949075G>A	ENST00000528851.1	-	2	266	c.126C>T	c.(124-126)caC>caT	p.H42H	MS4A6A_ENST00000426738.2_Silent_p.H42H|MS4A6A_ENST00000530839.1_Silent_p.H42H|MS4A6A_ENST00000323961.3_Silent_p.H42H|MS4A6A_ENST00000529054.1_Silent_p.H70H|MS4A6A_ENST00000532169.1_Silent_p.H42H|MS4A6A_ENST00000412309.2_Silent_p.H70H|MS4A6A_ENST00000533023.1_Silent_p.H42H|MS4A6A_ENST00000420732.2_Silent_p.H42H			Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member 6A	42						integral to membrane	receptor activity	p.H42H(1)		endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGATTTCTGCGTGTAGATGTT	0.468000													29	95					0	0	1	0	0
SMR3A	26952	broad.mit.edu	37	4	71232487	71232487	+	Missense_Mutation	SNP	G	G	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr4:71232487G>T	ENST00000226460.4	+	3	277	c.181G>T	c.(181-183)Ggg>Tgg	p.G61W		NM_012390.3	NP_036522.3	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3A	61	Pro-rich.					extracellular region				endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)	15		all_hematologic(202;0.196)				CTATGGTCCAGGGAGATTTCC	0.552000													13	80					9.05144e-12	9.85601e-12	1	1	0
LACE1	246269	broad.mit.edu	37	6	108645100	108645100	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr6:108645100G>A	ENST00000368977.4	+	2	397	c.211G>A	c.(211-213)Gtt>Att	p.V71I		NM_145315.3	NP_660358.2	Q8WV93	LACE1_HUMAN	lactation elevated 1	71							ATP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		AGCTTTGGCCGTTTGCCATGG	0.398000													24	133					0	0	1	0	0
ISLR2	57611	broad.mit.edu	37	15	74425299	74425299	+	Silent	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr15:74425299C>T	ENST00000361742.3	+	4	973	c.204C>T	c.(202-204)cgC>cgT	p.R68R	ISLR2_ENST00000445793.1_Silent_p.R68R|ISLR2_ENST00000435464.1_Silent_p.R68R|ISLR2_ENST00000565540.1_Silent_p.R68R|ISLR2_ENST00000419208.1_Silent_p.R68R|ISLR2_ENST00000453268.2_Silent_p.R68R|ISLR2_ENST00000561975.1_Intron|ISLR2_ENST00000565159.1_Silent_p.R68R	NM_001130136.1|NM_020851.2	NP_001123608.1|NP_065902.1	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing leucine-rich repeat 2	68					positive regulation of axon extension	cell surface|integral to membrane|plasma membrane				breast(3)|endometrium(6)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36						TGCTGCGGCGCGGGGCCTTCG	0.642000													4	61					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145379666	145379666	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr5:145379666G>A	ENST00000511217.1	+	2	476	c.424G>A	c.(424-426)Ggt>Agt	p.G142S	SH3RF2_ENST00000359120.4_Missense_Mutation_p.G142S			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	142	SH3 1.						ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAGAATCCCGGTGACCTAAG	0.483000													12	56					0	0	1	0	0
MUC15	143662	broad.mit.edu	37	11	26584679	26584679	+	Silent	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr11:26584679G>A	ENST00000436318.2	-	3	1042	c.909C>T	c.(907-909)gaC>gaT	p.D303D	MUC15_ENST00000455601.2_Silent_p.D276D|ANO3_ENST00000531568.1_Intron|ANO3_ENST00000525139.1_Intron|MUC15_ENST00000281268.8_Intron|MUC15_ENST00000527569.1_Intron|ANO3_ENST00000529242.1_3'UTR|ANO3_ENST00000537978.1_Intron|ANO3_ENST00000256737.3_Intron|MUC15_ENST00000529533.1_Silent_p.D303D			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	276						extracellular region|integral to membrane|plasma membrane		p.D276D(2)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						CATTTCTGTCGTCATAAAGTC	0.408000													22	102					0	0	1	0	0
OR4X2	119764	broad.mit.edu	37	11	48266656	48266656	+	Translation_Start_Site	SNP	A	A	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr11:48266656A>T	ENST00000302329.3	+	1	49	c.1A>T	c.(1-3)Atg>Ttg	p.M1L		NM_001004727.1	NP_001004727.1	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X, member 2	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(4)|lung(12)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	20						CATACACAACATGACTGAATT	0.418000													7	79					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42166142	42166142	+	Silent	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr15:42166142G>A	ENST00000320955.6	-	25	5018	c.4791C>T	c.(4789-4791)atC>atT	p.I1597I		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1597					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		ACTGCTCCACGATGTGTTGGG	0.647000													4	33					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2787238	2787238	+	Missense_Mutation	SNP	G	G	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr3:2787238G>T	ENST00000397461.1	+	5	599	c.215G>T	c.(214-216)gGt>gTt	p.G72V	CNTN4_ENST00000418658.1_Missense_Mutation_p.G72V|CNTN4_ENST00000427331.1_Missense_Mutation_p.G72V	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	72	Ig-like C2-type 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GTTGACACTGGTATGGATTTC	0.378000													31	113					1.60099e-16	1.78292e-16	1	1	0
PNMA3	29944	broad.mit.edu	37	X	152226591	152226591	+	Silent	SNP	A	A	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chrX:152226591A>T	ENST00000447306.1	+	2	1515	c.1179A>T	c.(1177-1179)cgA>cgT	p.R393R	PNMA3_ENST00000370264.4_Silent_p.R393R|PNMA3_ENST00000370265.4_Silent_p.R393R	NM_013364.4	NP_037496.3	Q9UL41	PNMA3_HUMAN	paraneoplastic Ma antigen 3	393	Arg-rich.				apoptosis	nucleolus	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					GCCAACACCGAAGGGGTGGTG	0.607000													7	54					0	0	1	0	0
KAT5	10524	broad.mit.edu	37	11	65486590	65486590	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr11:65486590C>T	ENST00000341318.4	+	13	1813	c.1579C>T	c.(1579-1581)Cgg>Tgg	p.R527W	KAT5_ENST00000534650.1_Missense_Mutation_p.R283W|KAT5_ENST00000530446.1_Missense_Mutation_p.R475W|KAT5_ENST00000377046.3_Missense_Mutation_p.R494W|KAT5_ENST00000352980.4_Missense_Mutation_p.R442W|RNASEH2C_ENST00000308418.4_3'UTR	NM_182710.2	NP_874369.1	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5	494					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)	21						GCGGCTCCTGCGGATCGACTC	0.607000													8	32					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28539970	28539970	+	Silent	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr6:28539970G>A	ENST00000452236.2	-	4	4313	c.3696C>T	c.(3694-3696)acC>acT	p.T1232T		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1232					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						atccttcgtcggtagccagct	0.343000													10	56					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204438817	204438817	+	Silent	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr1:204438817G>A	ENST00000367187.3	-	3	670	c.114C>T	c.(112-114)tcC>tcT	p.S38S	PIK3C2B_ENST00000424712.2_Silent_p.S38S	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	38	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GCCGGAGCCGGGACAGGGCAT	0.587000													13	469					0	0	1	0	0
MS4A7	58475	broad.mit.edu	37	11	60152586	60152586	+	Missense_Mutation	SNP	T	T	G			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr11:60152586T>G	ENST00000300184.3	+	3	369	c.173T>G	c.(172-174)tTg>tGg	p.L58W	MS4A7_ENST00000358246.1_Intron|MS4A14_ENST00000531787.1_Intron|MS4A7_ENST00000530234.2_Missense_Mutation_p.L58W|MS4A7_ENST00000534016.1_Intron	NM_021201.4|NM_206939.1	NP_067024.1|NP_996822.1	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member 7	58						integral to membrane	receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(8)|ovary(1)|skin(1)	20						TGTTGCCTGTTGATTTCAAGT	0.438000													18	124					0	0	1	0	0
TMEM201	199953	broad.mit.edu	37	1	9661231	9661231	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr1:9661231C>A	ENST00000340305.5	+	5	684	c.675C>A	c.(673-675)tgC>tgA	p.C225*	TMEM201_ENST00000377376.4_Nonsense_Mutation_p.C225*|TMEM201_ENST00000340381.6_Nonsense_Mutation_p.C225*	NM_001010866.3	NP_001010866.1	Q5SNT2	TM201_HUMAN	transmembrane protein 201	225						integral to membrane|nuclear inner membrane				lung(3)|upper_aerodigestive_tract(1)	4	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		TCCTGGCCTGCGCCTTCCTAC	0.657000													4	96					0.014758	0.014758	1	1	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													3	46					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348857	89348857	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr16:89348857G>A	ENST00000301030.4	-	9	4553	c.4093C>T	c.(4093-4095)Cga>Tga	p.R1365*	ANKRD11_ENST00000378330.2_Nonsense_Mutation_p.R1365*	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1365	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTCTTGGCTCGCTCTCGGTCG	0.562000													14	55					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32632119	32632119	+	Silent	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr9:32632119C>T	ENST00000242310.4	-	1	3548	c.3459G>A	c.(3457-3459)ctG>ctA	p.L1153L		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1153					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGCCTGCTACCAGTAGCATTC	0.483000													12	65					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28913648	28913648	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr18:28913648G>A	ENST00000257192.4	+	7	993	c.781G>A	c.(781-783)Gat>Aat	p.D261N		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	261	Cadherin 2.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TAAAATCCTCGATGTCAATGA	0.398000													9	46					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204438785	204438785	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr1:204438785G>A	ENST00000367187.3	-	3	702	c.146C>T	c.(145-147)gCc>gTc	p.A49V	PIK3C2B_ENST00000424712.2_Missense_Mutation_p.A49V	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	49	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GTTCTGCTTGGCTCTGTTCTC	0.592000													17	474					0	0	1	0	0
CLEC2B	9976	broad.mit.edu	37	12	10005934	10005934	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr12:10005934C>T	ENST00000228438.2	-	5	1348	c.415G>A	c.(415-417)Gaa>Aaa	p.E139K	CLEC2B_ENST00000538152.1_Missense_Mutation_p.E70K	NM_005127.2	NP_005118.2	Q92478	CLC2B_HUMAN	C-type lectin domain family 2, member B	139	C-type lectin.					integral to plasma membrane	sugar binding			endometrium(1)|large_intestine(3)|lung(1)	5						CATTTTCTTTCGGTGTAACAT	0.383000													7	32					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16162084	16162084	+	Silent	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr16:16162084C>T	ENST00000399408.2	+	13	1924	c.1749C>T	c.(1747-1749)ttC>ttT	p.F583F	ABCC1_ENST00000346370.5_Silent_p.F583F|ABCC1_ENST00000351154.5_Silent_p.F583F|ABCC1_ENST00000345148.5_Silent_p.F583F|ABCC1_ENST00000399410.3_Silent_p.F583F|ABCC1_ENST00000349029.5_Silent_p.F583F			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	583	ABC transmembrane type-1 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	AGACAGCCTTCGTGTCTTTGG	0.562000													31	91					0	0	1	0	0
OPN1LW	5956	broad.mit.edu	37	X	153421855	153421855	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chrX:153421855C>G	ENST00000369951.4	+	5	891	c.831C>G	c.(829-831)taC>taG	p.Y277*	OPN1LW_ENST00000463296.1_3'UTR	NM_020061.4	NP_064445.1	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	277					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	15	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCTTTGCGTACTGCGTCTGCT	0.567000													52	200					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47681909	47681909	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr6:47681909G>A	ENST00000283303.2	+	6	1186	c.928G>A	c.(928-930)Gtg>Atg	p.V310M	GPR115_ENST00000327753.3_Missense_Mutation_p.V310M|GPR115_ENST00000371220.1_Missense_Mutation_p.V367M	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	310					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CTTGCAAAATGTGAGTCTTCC	0.468000													9	62					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158622273	158622273	+	Missense_Mutation	SNP	A	A	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr1:158622273A>T	ENST00000368148.3	-	23	3539	c.3359T>A	c.(3358-3360)tTt>tAt	p.F1120Y	SPTA1_ENST00000368147.3_Missense_Mutation_p.F1120Y	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1120					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GAACTCATCAAACTTTTTCTG	0.398000													15	112					0	0	1	0	0
ZNF285	26974	broad.mit.edu	37	19	44891689	44891689	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr19:44891689C>T	ENST00000330997.4	-	4	782	c.718G>A	c.(718-720)Gcc>Acc	p.A240T	ZNF285_ENST00000591679.1_Missense_Mutation_p.A247T|ZNF285_ENST00000544719.2_Missense_Mutation_p.A240T|CTC-512J12.6_ENST00000588212.1_Intron	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						TCTGCAAAGGCCACCCCACAG	0.433000													26	128					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24771450	24771450	+	Silent	SNP	G	G	C			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr8:24771450G>C	ENST00000221166.5	+	1	926	c.144G>C	c.(142-144)gtG>gtC	p.V48V	NEFM_ENST00000518131.1_Silent_p.V48V|NEFM_ENST00000521540.1_3'UTR|GS1-72M22.1_ENST00000607058.1_RNA|NEFM_ENST00000437366.2_Silent_p.V48V			P07197	NFM_HUMAN	neurofilament, medium polypeptide	48	Head.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CCAGCACCGTGTCCTCCTCCT	0.687000													8	37					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30585186	30585186	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr20:30585186C>T	ENST00000217299.3	+	3	1840	c.1666C>T	c.(1666-1668)Cct>Tct	p.P556S		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	556						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GTACTCCTCACCTGCCACGCC	0.587000													17	59					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79437135	79437135	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr4:79437135G>A	ENST00000264895.6	+	66	10797	c.10357G>A	c.(10357-10359)Gtc>Atc	p.V3453I		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3448					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GCTGATTGACGTCTGTGGGGG	0.537000													4	21					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604671	179604671	+	Missense_Mutation	SNP	A	A	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr2:179604671A>T	ENST00000589042.1	-	48	13513	c.13289T>A	c.(13288-13290)gTa>gAa	p.V4430E	TTN_ENST00000359218.5_Missense_Mutation_p.V4192E|TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.V4113E|TTN_ENST00000342175.6_Missense_Mutation_p.V4259E|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V4067E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4113	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGATGTTTACAGCCTCGAC	0.463000													18	96					0	0	1	0	0
TXNDC15	79770	broad.mit.edu	37	5	134210146	134210146	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr5:134210146C>T	ENST00000358387.4	+	1	654	c.29C>T	c.(28-30)cCc>cTc	p.P10L		NM_024715.3	NP_078991.3	Q96J42	TXD15_HUMAN	thioredoxin domain containing 15	10					cell redox homeostasis	integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CGACGACCGCCCCGCGTCATG	0.716000													10	59					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136594291	136594291	+	Silent	SNP	G	G	A	rs148264625	byFrequency	TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr6:136594291G>A	ENST00000531224.1	-	7	2139	c.1887C>T	c.(1885-1887)aaC>aaT	p.N629N	BCLAF1_ENST00000353331.4_Silent_p.N627N|BCLAF1_ENST00000527536.1_Silent_p.N629N|BCLAF1_ENST00000392348.2_Silent_p.N627N|BCLAF1_ENST00000530767.1_Silent_p.N456N|BCLAF1_ENST00000527759.1_Silent_p.N627N	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	629			N -> S (in dbSNP:rs7381749).		induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGAACCGCTCGTTTAGGGTCA	0.393000													21	298					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107603490	107603490	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr7:107603490G>A	ENST00000393561.1	-	13	1973	c.1789C>T	c.(1789-1791)Cgg>Tgg	p.R597W	LAMB1_ENST00000393560.1_Missense_Mutation_p.R573W|LAMB1_ENST00000222399.6_Missense_Mutation_p.R573W			P07942	LAMB1_HUMAN	laminin, beta 1	573	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATATATTGCCGCTCCACTATG	0.448000													18	130					0	0	1	0	0
TRBV7-3	0	broad.mit.edu	37	7	142247149	142247149	+	RNA	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr7:142247149G>A	ENST00000390361.3	-	0	356																											GAGTCCCCCCGCTCTGTGCGC	0.572000													13	77					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65788325	65788325	+	Silent	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr11:65788325C>T	ENST00000312106.5	-	6	2021	c.1884G>A	c.(1882-1884)acG>acA	p.T628T		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	628					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						AGTCATCCAGCGTGAGCAAGG	0.637000													6	31					0	0	1	0	0
ACKR6	0	broad.mit.edu	37	17	6380417	6380417	+	Silent	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr17:6380417C>T	ENST00000262483.8	-	9	1104	c.1017G>A	c.(1015-1017)ccG>ccA	p.P339P	ACKR6_ENST00000421306.3_Silent_p.P303P	NM_031220.3	NP_112497.2																					TCTGTTTCCGCGGCAACGGCC	0.582000													8	30					0	0	1	0	0
LINC00202-2	0	broad.mit.edu	37	10	26939502	26939502	+	RNA	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr10:26939502C>T	ENST00000544033.1	+	0	5435					NR_026794.1																						ATGGCACCACCCAGCCCAATG	0.468000													10	45					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141407833	141407833	+	Silent	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr8:141407833C>T	ENST00000389328.4	-	7	1328	c.1314G>A	c.(1312-1314)gcG>gcA	p.A438A	TRAPPC9_ENST00000438773.2_Silent_p.A340A|TRAPPC9_ENST00000389327.3_Silent_p.A331A	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	340					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						CAATCACTCCCGCATTCTTAT	0.433000													13	101					0	0	1	0	0
ISPD	729920	broad.mit.edu	37	7	16445756	16445756	+	Missense_Mutation	SNP	T	T	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr7:16445756T>A	ENST00000407010.2	-	2	463	c.464A>T	c.(463-465)cAt>cTt	p.H155L	ISPD_ENST00000399310.3_Missense_Mutation_p.H155L	NM_001101426.3	NP_001094896.1	A4D126	ISPD_HUMAN	isoprenoid synthase domain containing	155					isoprenoid biosynthetic process		nucleotidyltransferase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)	9						CACAGCATCATGGATAATCAC	0.433000										Multiple Myeloma(15;0.18)			10	65					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204438640	204438640	+	Silent	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr1:204438640G>A	ENST00000367187.3	-	3	847	c.291C>T	c.(289-291)tcC>tcT	p.S97S	PIK3C2B_ENST00000424712.2_Silent_p.S97S	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	97	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			CTTCCTGTGGGGAGAGTGAGT	0.572000													13	390					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11573026	11573026	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr17:11573026C>T	ENST00000262442.3	+	17	3336	c.3268C>T	c.(3268-3270)Cga>Tga	p.R1090*	DNAH9_ENST00000454412.2_Nonsense_Mutation_p.R1090*	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1090	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AATTGATATTCGACCCTTTAA	0.443000													23	153					0	0	1	0	0
CRX	1406	broad.mit.edu	37	19	48339541	48339541	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr19:48339541C>T	ENST00000221996.7	+	3	348	c.142C>T	c.(142-144)Cgg>Tgg	p.R48W	TPRX2P_ENST00000535362.1_Intron|CRX_ENST00000539067.1_Missense_Mutation_p.R48W	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	48					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		CACCTTCACCCGGAGCCAACT	0.632000													8	52					0	0	1	0	0
SUMF2	25870	broad.mit.edu	37	7	56146102	56146102	+	Missense_Mutation	SNP	C	C	T	rs150538960		TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr7:56146102C>T	ENST00000434526.2	+	8	810	c.779C>T	c.(778-780)cCg>cTg	p.P260L	SUMF2_ENST00000275607.9_Missense_Mutation_p.P153L|SUMF2_ENST00000395436.2_Missense_Mutation_p.P245L|SUMF2_ENST00000395435.2_Missense_Mutation_p.P176L|SUMF2_ENST00000342190.6_Intron|SUMF2_ENST00000437307.2_Missense_Mutation_p.P172L|SUMF2_ENST00000413756.1_Missense_Mutation_p.P241L	NM_001042469.1|NM_015411.2	NP_001035934.2|NP_056226.2	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2	241						endoplasmic reticulum lumen	metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	14	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ACAGCATCACCGTACCAGGCT	0.687000													7	92					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142606688	142606688	+	Silent	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr7:142606688G>A	ENST00000265310.1	-	14	2211	c.1863C>T	c.(1861-1863)tgC>tgT	p.C621C		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	621					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GCCCGAATTCGCACCCACAGA	0.607000													10	48					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150646032	150646032	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr7:150646032C>T	ENST00000392968.2	-	8	3336	c.2216G>A	c.(2215-2217)cGg>cAg	p.R739Q	KCNH2_ENST00000330883.4_Missense_Mutation_p.R495Q|KCNH2_ENST00000262186.5_Missense_Mutation_p.R835Q			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	835					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CAGGTCGTCCCGATGGATCTT	0.567000													8	75					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170050323	170050323	+	Silent	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr2:170050323G>A	ENST00000263816.3	-	47	9063	c.8778C>T	c.(8776-8778)gaC>gaT	p.D2926D		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2926	LDL-receptor class A 21.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CATTATCACCGTCACAGATCC	0.473000													18	111					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48256601	48256601	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr16:48256601G>A	ENST00000394747.1	-	5	1034	c.685C>T	c.(685-687)Cgc>Tgc	p.R229C	ABCC11_ENST00000394748.1_Missense_Mutation_p.R229C|ABCC11_ENST00000356608.2_Missense_Mutation_p.R229C|ABCC11_ENST00000353782.5_Missense_Mutation_p.R229C|ABCC11_ENST00000537808.1_Missense_Mutation_p.R229C	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	229	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				ATGGCTGTGCGTTGGTTGATG	0.483000													13	62					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241468646	241468646	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr2:241468646G>A	ENST00000391987.1	-	5	860	c.494C>T	c.(493-495)aCg>aTg	p.T165M	ANKMY1_ENST00000403283.1_Intron|ANKMY1_ENST00000401804.1_Missense_Mutation_p.T254M|ANKMY1_ENST00000373318.2_Intron|ANKMY1_ENST00000373320.4_Intron|ANKMY1_ENST00000361678.4_Intron|ANKMY1_ENST00000406958.1_Intron|ANKMY1_ENST00000272972.3_Missense_Mutation_p.T165M|ANKMY1_ENST00000405523.3_Intron|ANKMY1_ENST00000405002.1_Intron|ANKMY1_ENST00000462004.1_Intron|ANKMY1_ENST00000536462.1_Intron			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	165							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TGGAGGCAGCGTTAGGTTGTC	0.502000													9	44					0	0	1	0	0
SPESP1	246777	broad.mit.edu	37	15	69238119	69238119	+	Silent	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr15:69238119C>T	ENST00000310673.3	+	2	400	c.246C>T	c.(244-246)gaC>gaT	p.D82D	NOX5_ENST00000455873.3_Intron|NOX5_ENST00000260364.5_Intron|SPESP1_ENST00000560188.1_3'UTR|NOX5_ENST00000448182.3_Intron|RP11-809H16.2_ENST00000557966.1_RNA	NM_145658.3	NP_663633.1	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1	82					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						CACATGGAGACGCTTCAACTG	0.393000													21	64					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	71008236	71008236	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr10:71008236G>A	ENST00000354624.5	+	10	1455	c.1322G>A	c.(1321-1323)cGc>cAc	p.R441H	HKDC1_ENST00000488706.1_3'UTR|HKDC1_ENST00000395086.2_Missense_Mutation_p.R441H	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	441					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity	p.V440fs*51(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						TGTGATGTCCGCTTCCTCCTG	0.597000													21	56					0	0	1	0	0
UFSP2	55325	broad.mit.edu	37	4	186339907	186339907	+	Missense_Mutation	SNP	C	C	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr4:186339907C>A	ENST00000264689.6	-	3	216	c.100G>T	c.(100-102)Gca>Tca	p.A34S	UFSP2_ENST00000502282.1_5'UTR	NM_018359.3	NP_060829.2	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	34						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		TGTTTCAGTGCCTTCTTGAGA	0.343000													9	52					0.00448238	0.00457576	1	1	0
ZXDB	158586	broad.mit.edu	37	X	57619831	57619831	+	Silent	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chrX:57619831C>T	ENST00000374888.1	+	1	1563	c.1350C>T	c.(1348-1350)ggC>ggT	p.G450G		NM_007157.3	NP_009088.1	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	450	Required for interaction with ZXDC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(2)|skin(6)	27						GTCACACCGGCGAGAGACCTT	0.483000													16	75					0	0	1	0	0
WASH3P	0	broad.mit.edu	37	15	102515299	102515299	+	RNA	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr15:102515299G>A	ENST00000557932.1	+	0	1145																		p.G374S(10)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGGGGGCATCGGCAAGGCCAA	0.652000													3	20					0	0	1	0	0
OR51F2	119694	broad.mit.edu	37	11	4842972	4842972	+	Silent	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr11:4842972C>T	ENST00000322110.5	+	1	422	c.357C>T	c.(355-357)caC>caT	p.H119H	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004753.1	NP_001004753.1	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F, member 2	119					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTTTCTACACGGATTTACTT	0.468000													21	139					0	0	1	0	0
PPM1N	147699	broad.mit.edu	37	19	46002331	46002331	+	Silent	SNP	C	C	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr19:46002331C>A	ENST00000324688.4	+	1	467	c.367C>A	c.(367-369)Cgg>Agg	p.R123R	PPM1N_ENST00000456399.2_Intron|PPM1N_ENST00000451287.2_Silent_p.R201R|PPM1N_ENST00000396737.2_Intron|PPM1N_ENST00000401705.1_Intron			Q8N819	PPM1N_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)	201	PP2C-like.						magnesium ion binding|manganese ion binding|phosphoprotein phosphatase activity			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)	9						AGAGGACCACCGGCCCCTTCG	0.736000													7	14					0.00198382	0.00204647	1	1	0
CYP3A4	1576	broad.mit.edu	37	7	99367747	99367747	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr7:99367747C>A	ENST00000336411.2	-	5	613	c.430G>T	c.(430-432)Gag>Tag	p.E144*	CYP3A4_ENST00000354593.2_Intron	NM_001202855.2|NM_017460.5	NP_001189784.1|NP_059488.2	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 4	144					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			breast(3)|central_nervous_system(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TTTCATACCTCCTTGAGTTTT	0.393000													13	65					0.000422831	0.000445564	1	1	0
ANO2	57101	broad.mit.edu	37	12	5708776	5708776	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr12:5708776G>A	ENST00000356134.5	-	22	2181	c.2110C>T	c.(2110-2112)Cga>Tga	p.R704*	ANO2_ENST00000327087.8_Nonsense_Mutation_p.R703*|ANO2_ENST00000546188.1_Nonsense_Mutation_p.R704*	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	708						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity	p.R704*(1)		central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						TTCAGCTTTCGAAATAGTTTC	0.428000													10	55					0	0	1	0	0
SCRN1	9805	broad.mit.edu	37	7	29976211	29976211	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr7:29976211G>A	ENST00000426154.1	-	6	1042	c.866C>T	c.(865-867)cCg>cTg	p.P289L	SCRN1_ENST00000242059.5_Missense_Mutation_p.P289L|SCRN1_ENST00000409497.1_Missense_Mutation_p.P289L|SCRN1_ENST00000416113.2_Missense_Mutation_p.P115L	NM_001145513.1	NP_001138985.1	Q12765	SCRN1_HUMAN	secernin 1	289					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity	p.P289Q(1)|p.P309Q(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(2)|prostate(2)|skin(2)	25						GTGAATGCACGGAGAGCTTCT	0.522000													26	160					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27217702	27217702	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr9:27217702G>A	ENST00000380036.4	+	19	3450	c.3008G>A	c.(3007-3009)cGc>cAc	p.R1003H	TEK_ENST00000519097.1_Missense_Mutation_p.R855H|TEK_ENST00000406359.4_Missense_Mutation_p.R960H	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	1003	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CTCCCAGTGCGCTGGATGGCC	0.483000													10	33					0	0	1	0	0
OTOP2	92736	broad.mit.edu	37	17	72926410	72926410	+	Missense_Mutation	SNP	T	T	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr17:72926410T>A	ENST00000331427.4	+	6	772	c.680T>A	c.(679-681)cTc>cAc	p.L227H	OTOP2_ENST00000580223.1_Missense_Mutation_p.L227H	NM_178160.2	NP_835454.1	Q7RTS6	OTOP2_HUMAN	otopetrin 2	227						integral to membrane				breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|prostate(4)|skin(1)|urinary_tract(2)	39	all_lung(278;0.172)|Lung NSC(278;0.207)					GACTCCTGCCTCTGCAGCACG	0.577000													39	170					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128196	152128196	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr1:152128196C>T	ENST00000316073.3	-	3	1443	c.1379G>A	c.(1378-1380)aGt>aAt	p.S460N		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	460	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						ATAGTGGGAACTCTGGCCTTG	0.512000													10	806					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7645562	7645562	+	Silent	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr16:7645562C>T	ENST00000340209.4	+	5	792	c.495C>T	c.(493-495)ttC>ttT	p.F165F	RBFOX1_ENST00000355637.4_Silent_p.F180F|RBFOX1_ENST00000547372.1_Silent_p.F203F|RBFOX1_ENST00000550418.1_Silent_p.F160F|RBFOX1_ENST00000552089.1_Silent_p.F177F|RBFOX1_ENST00000436368.2_Silent_p.F180F|RBFOX1_ENST00000311745.5_Silent_p.F180F|RBFOX1_ENST00000553186.1_Silent_p.F160F|RBFOX1_ENST00000547338.1_Silent_p.F160F|RBFOX1_ENST00000535565.2_Intron|RBFOX1_ENST00000422070.4_Silent_p.F203F			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	160	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						GATTTGGTTTCGTAACTTTCG	0.443000													21	101					0	0	1	0	0
TMEM52	339456	broad.mit.edu	37	1	1849422	1849422	+	Missense_Mutation	SNP	G	G	C			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr1:1849422G>C	ENST00000378602.3	-	2	724	c.484C>G	c.(484-486)Ccc>Gcc	p.P162A	TMEM52_ENST00000310991.3_Missense_Mutation_p.P177A			Q8NDY8	TMM52_HUMAN	transmembrane protein 52	177						integral to membrane				NS(1)|prostate(1)|stomach(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGAGGGCTGGGTTTCTGGGAG	0.622000													11	136					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104984675	104984675	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chrX:104984675C>T	ENST00000372582.1	+	8	1795	c.1039C>T	c.(1039-1041)Cgt>Tgt	p.R347C	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.R347C|IL1RAPL2_ENST00000485671.1_3'UTR	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	347	Ig-like C2-type 3.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity	p.R347C(1)		breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TGTTTTGCTGCGTAAAAAGGG	0.368000													13	84					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7646393	7646393	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr17:7646393C>T	ENST00000572933.1	+	12	3297	c.1837C>T	c.(1837-1839)Cgg>Tgg	p.R613W	DNAH2_ENST00000389173.2_Missense_Mutation_p.R613W|DNAH2_ENST00000082259.3_Missense_Mutation_p.R695W|DNAH2_ENST00000570791.1_Missense_Mutation_p.R695W			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	613	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TTGCATTCGGCGGTTGGATAC	0.527000													7	64					0	0	1	0	0
AC226119.5	0	broad.mit.edu	37	4	3954857	3954857	+	RNA	SNP	C	C	A	rs17410899		TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr4:3954857C>A	ENST00000281228.8	-	0	141				FAM86EP_ENST00000313946.8_RNA																							AATATCCCGCCGCAGCTCAGA	0.488000													3	80					0.000602214	0.000627841	1	1	0
SLCO1B1	10599	broad.mit.edu	37	12	21355502	21355502	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr12:21355502G>A	ENST00000256958.2	+	10	1309	c.1213G>A	c.(1213-1215)Gtt>Att	p.V405I		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	405					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	ACTGAACACCGTTGGAATTGC	0.313000													20	46					0	0	1	0	0
EYA4	2070	broad.mit.edu	37	6	133789766	133789766	+	Silent	SNP	G	G	A			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr6:133789766G>A	ENST00000367895.5	+	11	1331	c.867G>A	c.(865-867)acG>acA	p.T289T	EYA4_ENST00000525849.1_Silent_p.T266T|EYA4_ENST00000355167.3_Silent_p.T289T|EYA4_ENST00000452339.2_Silent_p.T235T|EYA4_ENST00000431403.2_Silent_p.T289T|EYA4_ENST00000430974.2_Silent_p.T235T|EYA4_ENST00000531901.1_Silent_p.T289T|EYA4_ENST00000355286.6_Silent_p.T266T	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	289					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CAGCATCAACGTATGGAGCGT	0.423000													13	52					0	0	1	0	0
CLEC3B	7123	broad.mit.edu	37	3	45072406	45072406	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr3:45072406delC	ENST00000296130.4	+	2	377	c.197delC	c.(196-198)gcfs	p.A66fs	CLEC3B_ENST00000428034.1_Frame_Shift_Del_p.A24fs|CLEC3B_ENST00000490386.1_3'UTR	NM_003278.2	NP_003269.2	P05452	TETN_HUMAN	C-type lectin domain family 3, member B	66					skeletal system development	extracellular space	protein binding|sugar binding			endometrium(1)|lung(3)	4				BRCA - Breast invasive adenocarcinoma(193;0.00863)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGCAGCAGGCCCTGCAGACG	0.612													2	4	---	---	---	---					
DST	667	broad.mit.edu	37	6	56362694	56362695	+	Frame_Shift_Ins	INS	-	-	T			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr6:56362694_56362695insT	ENST00000370754.5	-	81	19959_19960	c.19960_19961insA	c.(19960-19962)agafs	p.R6654fs	DST_ENST00000446842.2_Frame_Shift_Ins_p.R6150fs|DST_ENST00000370769.4_Frame_Shift_Ins_p.R6476fs|DST_ENST00000370788.2_Frame_Shift_Ins_p.R4279fs|DST_ENST00000361203.3_Frame_Shift_Ins_p.R6365fs|DST_ENST00000312431.6_3'UTR|DST_ENST00000340834.4_5'UTR|DST_ENST00000244364.6_Frame_Shift_Ins_p.R4062fs|DST_ENST00000421834.2_Frame_Shift_Ins_p.R4388fs			Q03001	DYST_HUMAN	dystonin	6474					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CCTTTGTTCTGTTTTTTCCAAA	0.391													8	44	---	---	---	---					
DYNC2H1	79659	broad.mit.edu	37	11	103116061	103116061	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr11:103116061delC	ENST00000375735.2	+	65	10144	c.10000delC	c.(10000-10002)ctfs	p.P3334fs	DYNC2H1_ENST00000398093.3_Frame_Shift_Del_p.P3341fs|DYNC2H1_ENST00000334267.7_Intron	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3334	AAA 5 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TGGTGTAGAACCTGTTCTTTA	0.313													2	4	---	---	---	---					
hsa-mir-7162	0	broad.mit.edu	37	15	62538522	62538523	+	RNA	INS	-	-	GA	rs3055695		TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr15:62538522_62538523insGA	ENST00000570077.1	-	0	693_694																											GGGGGCTCCGGGTAGGGGTTCA	0.609													3	5	---	---	---	---					
FAM83D	81610	broad.mit.edu	37	20	37555323	37555325	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr20:37555323_37555325delGCG	ENST00000217429.4	+	1	369_371	c.328_330delGCG	c.(328-330)del	p.A116del		NM_030919.2	NP_112181.2	Q9H4H8	FA83D_HUMAN	family with sequence similarity 83, member D	86					cell division|mitosis	cytoplasm|spindle pole				endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)|stomach(1)	28		Myeloproliferative disorder(115;0.00878)				AGAGGAGGGCgcggcggcggcgg	0.719													2	4	---	---	---	---					
MIR3648	0	broad.mit.edu	37	21	9825838	9825839	+	RNA	INS	-	-	GCG	rs3052281		TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chr21:9825838_9825839insGCG	ENST00000581792.1	+	0	7_8					NR_037421.1																						cggccgcgactgcggcggcggt	0.842													4	3	---	---	---	---					
DCX	1641	broad.mit.edu	37	X	110644519	110644519	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E1-A7YN-01A-11D-A34A-08	TCGA-E1-A7YN-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb1831c-3b62-45ce-8750-31fa7f3ebe7f	7a87f52e-8414-45c7-befa-a0acc48b6fbc	g.chrX:110644519delT	ENST00000338081.3	-	3	818	c.647delA	c.(646-648)agfs	p.K216fs	DCX_ENST00000371993.2_Frame_Shift_Del_p.K135fs|DCX_ENST00000488120.1_Frame_Shift_Del_p.K135fs|DCX_ENST00000356915.2_Frame_Shift_Del_p.K135fs|DCX_ENST00000356220.3_Frame_Shift_Del_p.K135fs|DCX_ENST00000496551.1_5'UTR	NM_000555.3	NP_000546.2	O43602	DCX_HUMAN	doublecortin	216	Doublecortin 1.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|skin(6)|upper_aerodigestive_tract(1)	41						GTACTCCACCTTTTTAAAGAA	0.403													17	88	---	---	---	---					
