Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
THEG	51298	broad.mit.edu	37	19	367082	367082	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr19:367082C>T	ENST00000342640.4	-	7	938	c.896G>A	c.(895-897)cGc>cAc	p.R299H	THEG_ENST00000346878.2_Missense_Mutation_p.R275H	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	299					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGAAGGAGGCGGTTATGGTC	0.572000													41	114					0	0	1	0	0
NPIPA5	100288332	broad.mit.edu	37	16	15457701	15457701	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr16:15457701G>A	ENST00000360151.4	-	8	867	c.868C>T	c.(868-870)Ctc>Ttc	p.L290F		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5									p.L290F(2)									AGGGGAGTGAGCAGACACTCG	0.562000													4	109					0	0	1	0	0
CPNE9	151835	broad.mit.edu	37	3	9754444	9754444	+	Silent	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr3:9754444G>A	ENST00000383832.3	+	9	667	c.477G>A	c.(475-477)ctG>ctA	p.L159L	CPNE9_ENST00000383831.3_Silent_p.L159L	NM_153635.2	NP_705899.2	Q8IYJ1	CPNE9_HUMAN	copine family member IX	159	C2 2.									breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16	Medulloblastoma(99;0.227)					CAAACAAGCTGGACAAGAAGG	0.517000													43	98					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89717661	89717661	+	Nonsense_Mutation	SNP	C	C	G			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr10:89717661C>G	ENST00000371953.3	+	7	2043	c.686C>G	c.(685-687)tCa>tGa	p.S229*	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	229	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.S229*(6)|p.R55fs*1(5)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TCCTCCAATTCAGGACCCACA	0.423000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			12	96					0	0	1	0	0
AGAP10	728127	broad.mit.edu	37	10	47207813	47207813	+	Splice_Site	SNP	T	T	C			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr10:47207813T>C	ENST00000355232.3	-	5	3482	c.471_splice	c.e5+1	p.H157_splice	AGAP10_ENST00000413193.2_Splice_Site_p.H228_splice|RP11-144G6.12_ENST00000605970.1_RNA|AGAP10_ENST00000452145.2_Splice_Site_p.H132_splice					ArfGAP with GTPase domain, ankyrin repeat and PH domain 10									p.H228R(20)		endometrium(5)|kidney(3)|lung(1)|prostate(2)|urinary_tract(1)	12						TTTACTTACATGGTTTGTACA	0.294000													3	13					0	0	1	0	0
TBC1D22B	55633	broad.mit.edu	37	6	37298922	37298922	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr6:37298922G>A	ENST00000373491.3	+	13	1638	c.1492G>A	c.(1492-1494)Gat>Aat	p.D498N		NM_017772.2	NP_060242.2	Q9NU19	TB22B_HUMAN	TBC1 domain family, member 22B	498						intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|prostate(1)	15			OV - Ovarian serous cystadenocarcinoma(102;0.241)			CATGTTTGCCGATGCCCCAAA	0.547000													4	114					0	0	1	0	0
AP000525.9	0	broad.mit.edu	37	22	16150968	16150968	+	RNA	SNP	C	C	T	rs138311033	by1000genomes	TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr22:16150968C>T	ENST00000447898.1	-	0	1146																											CAAATTTGGACTCTTGACTCT	0.403000													3	17					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4934534	4934534	+	Silent	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr16:4934534G>A	ENST00000345988.2	-	22	4211	c.4122C>T	c.(4120-4122)agC>agT	p.S1374S	PPL_ENST00000590782.2_Silent_p.S1372S	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	1374					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						CCACATCGATGCTCTCGGCAA	0.677000													5	206					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628287	29628287	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr20:29628287A>G	ENST00000278882.3	+	6	669	c.289A>G	c.(289-291)Ata>Gta	p.I97V	FRG1B_ENST00000439954.2_Missense_Mutation_p.I102V|FRG1B_ENST00000358464.4_Missense_Mutation_p.I97V																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AGCAGGGGACATAGAAGCAAA	0.373000													6	130					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119249746	119249746	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr9:119249746G>C	ENST00000313400.4	-	20	3489	c.3389C>G	c.(3388-3390)tCt>tGt	p.S1130C	ASTN2_ENST00000361477.3_Missense_Mutation_p.S182C|ASTN2_ENST00000373996.3_Missense_Mutation_p.S1126C|ASTN2_ENST00000288520.5_Missense_Mutation_p.S231C|ASTN2_ENST00000361209.2_Missense_Mutation_p.S1079C|ASTN2_ENST00000341734.4_Missense_Mutation_p.S182C			O75129	ASTN2_HUMAN	astrotactin 2	1130	Fibronectin type-III.					integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GCCCAGGCCAGAGAGTAAGTC	0.512000													22	39					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													4	22					0	0	1	0	0
CD300LD	100131439	broad.mit.edu	37	17	72576247	72576247	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr17:72576247G>A	ENST00000375352.1	-	4	559	c.479C>T	c.(478-480)cCg>cTg	p.P160L		NM_001115152.1	NP_001108624.1	Q6UXZ3	CLM4_HUMAN	CD300 molecule-like family member d	160						integral to membrane|plasma membrane	receptor activity			large_intestine(1)|lung(2)|prostate(1)|stomach(1)	5						GCTCTTGAGCGGGGACCTGTG	0.572000													3	13					0	0	1	0	0
ZNF175	7728	broad.mit.edu	37	19	52090031	52090031	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr19:52090031G>T	ENST00000262259.2	+	5	805	c.447G>T	c.(445-447)gaG>gaT	p.E149D	ZNF175_ENST00000436511.2_Intron	NM_007147.2	NP_009078.1	Q9Y473	ZN175_HUMAN	zinc finger protein 175	149					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		AGAAAGATGAGCAAAATCAAA	0.393000													3	37					0.115264	0.117665	1	1	0
CUBN	8029	broad.mit.edu	37	10	17142012	17142012	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr10:17142012T>C	ENST00000377833.4	-	14	1822	c.1757A>G	c.(1756-1758)cAg>cGg	p.Q586R		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	586	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCTGGTTGCTGTGTTTCCCA	0.378000													44	130					0	0	1	0	0
UBP1	7342	broad.mit.edu	37	3	33450750	33450750	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr3:33450750T>C	ENST00000283629.3	-	7	1326	c.797A>G	c.(796-798)tAt>tGt	p.Y266C	UBP1_ENST00000283628.5_Missense_Mutation_p.Y266C|UBP1_ENST00000447368.2_Missense_Mutation_p.Y266C	NM_001128161.1|NM_014517.4	NP_001121633.1|NP_055332.3	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a)	266					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|urinary_tract(2)	23						TGTGGTATCATAGGACGGCTG	0.383000													44	127					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24791834	24791834	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr14:24791834C>T	ENST00000310677.4	-	20	2536	c.2423G>A	c.(2422-2424)cGc>cAc	p.R808H	ADCY4_ENST00000418030.2_Missense_Mutation_p.R808H|ADCY4_ENST00000554068.2_Missense_Mutation_p.R808H	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	808					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		ACTTACCTGGCGAGCCAGGAC	0.557000													14	21					0	0	1	0	0
CWF19L1	55280	broad.mit.edu	37	10	101996663	101996663	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr10:101996663C>A	ENST00000354105.4	-	12	1404	c.1318G>T	c.(1318-1320)Gca>Tca	p.A440S	CWF19L1_ENST00000478047.1_5'UTR|CWF19L1_ENST00000370379.1_Intron	NM_018294.4	NP_060764.3	Q69YN2	C19L1_HUMAN	CWF19-like 1, cell cycle control (S. pombe)	440							catalytic activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(4)|pancreas(1)|prostate(1)|stomach(2)	17		Colorectal(252;0.117)		Epithelial(162;3.78e-10)|all cancers(201;3.1e-08)		TGCTCCTGTGCCTGGGTAATG	0.483000													4	172					0.150653	0.150653	1	1	0
GUCY2C	2984	broad.mit.edu	37	12	14804947	14804947	+	Silent	SNP	A	A	G			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr12:14804947A>G	ENST00000261170.3	-	14	1687	c.1551T>C	c.(1549-1551)gaT>gaC	p.D517D		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	517	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						TGTGCTTGAGATCTTTGAGAA	0.348000													19	55					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								19	32					0	0	1	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													6	40					0	0	1	0	0
CNOT4	4850	broad.mit.edu	37	7	135078909	135078909	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr7:135078909T>C	ENST00000428680.2	-	10	1658	c.1379A>G	c.(1378-1380)aAt>aGt	p.N460S	CNOT4_ENST00000361528.4_Missense_Mutation_p.N460S|CNOT4_ENST00000423368.2_Missense_Mutation_p.N463S|CNOT4_ENST00000451834.1_Missense_Mutation_p.N460S|CNOT4_ENST00000315544.5_Missense_Mutation_p.N463S|CNOT4_ENST00000356162.4_Intron|CNOT4_ENST00000414802.1_Intron|CNOT4_ENST00000541284.1_Missense_Mutation_p.N463S	NM_001008225.2	NP_001008226.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	463					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						ATTGAGAGAATTGGCATTTGT	0.502000													28	70					0	0	1	0	0
SLC35F1	222553	broad.mit.edu	37	6	118606389	118606389	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr6:118606389A>G	ENST00000360388.4	+	7	1091	c.890A>G	c.(889-891)tAc>tGc	p.Y297C		NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	297					transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		TTTGGTCTCTACAGCTTTATG	0.507000											OREG0017635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	75	176					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15374364	15374364	+	Missense_Mutation	SNP	T	T	G			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr6:15374364T>G	ENST00000341776.2	+	2	306	c.62T>G	c.(61-63)aTt>aGt	p.I21S	JARID2_ENST00000397311.3_De_novo_Start_InFrame	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	21					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGTGATGGGATTCCGTGGTCA	0.413000													78	168					0	0	1	0	0
GSN	2934	broad.mit.edu	37	9	124080948	124080948	+	Silent	SNP	G	G	A	rs145170518		TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr9:124080948G>A	ENST00000373823.3	+	17	1886	c.981G>A	c.(979-981)tcG>tcA	p.S327S	GSN_ENST00000341272.2_Silent_p.S327S|GSN_ENST00000394353.2_Silent_p.S338S|GSN_ENST00000412819.1_Silent_p.S327S|GSN_ENST00000545652.1_Silent_p.S335S|GSN_ENST00000436847.1_Silent_p.S338S|GSN_ENST00000373807.1_Silent_p.S109S|GSN_ENST00000373818.4_Silent_p.S378S|GSN_ENST00000373808.2_Silent_p.S327S|GSN_ENST00000449733.1_Silent_p.S327S			P06396	GELS_HUMAN	gelsolin	378					actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						CCCAGGTCTCGGTCCTTCCTG	0.632000													7	33					0	0	1	0	0
HHAT	55733	broad.mit.edu	37	1	210796935	210796935	+	Silent	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr1:210796935G>A	ENST00000367010.1	+	11	1538	c.1311G>A	c.(1309-1311)tcG>tcA	p.S437S	HHAT_ENST00000261458.3_Silent_p.S437S|HHAT_ENST00000367009.1_Silent_p.S127S|HHAT_ENST00000308852.6_Silent_p.S392S|HHAT_ENST00000545781.1_Silent_p.S374S|HHAT_ENST00000541565.1_Silent_p.S300S|HHAT_ENST00000545154.1_Silent_p.S438S|HHAT_ENST00000537898.1_Silent_p.S372S|HHAT_ENST00000413764.2_Silent_p.S437S|HHAT_ENST00000391905.3_Silent_p.S437S	NM_001170580.1	NP_001164051.1	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	437					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		GTTCCACCTCGATGCTGATCC	0.502000													108	231					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	51995064	51995064	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr19:51995064G>A	ENST00000291707.3	-	8	1674	c.1619C>T	c.(1618-1620)cCg>cTg	p.P540L	SIGLEC12_ENST00000598614.1_Missense_Mutation_p.P422L	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	540					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GTCATCTGCCGGGGATTCAAT	0.622000													11	11					0	0	1	0	0
FERMT3	83706	broad.mit.edu	37	11	63988554	63988554	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr11:63988554C>T	ENST00000279227.5	+	13	1719	c.1624C>T	c.(1624-1626)Cgc>Tgc	p.R542C	FERMT3_ENST00000345728.5_Missense_Mutation_p.R538C	NM_178443.2	NP_848537.1	Q86UX7	URP2_HUMAN	fermitin family member 3	542	FERM.				integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding	p.R538C(1)|p.R542C(1)		breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						GGCCCAGCTGCGCTTCATCCA	0.662000													42	65					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178921551	178921551	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr3:178921551A>T	ENST00000263967.3	+	5	1190	c.1033A>T	c.(1033-1035)Aat>Tat	p.N345Y		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	345					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AACCTACGTGAATGTAAATAT	0.303000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			24	59					0	0	1	0	0
PPM1H	57460	broad.mit.edu	37	12	63195840	63195840	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr12:63195840G>A	ENST00000228705.6	-	3	812	c.512C>T	c.(511-513)aCg>aTg	p.T171M		NM_020700.1	NP_065751.1	Q9ULR3	PPM1H_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1H	171	PP2C-like.						phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)	18			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		CAGCTGCTCCGTGATGTGGTG	0.667000													16	42					0	0	1	0	0
MAD1L1	8379	broad.mit.edu	37	7	2255588	2255588	+	Silent	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr7:2255588G>A	ENST00000406869.1	-	9	1413	c.856C>T	c.(856-858)Ctg>Ttg	p.L286L	MAD1L1_ENST00000402746.1_Silent_p.L194L|MAD1L1_ENST00000399654.2_Silent_p.L286L|MAD1L1_ENST00000265854.7_Silent_p.L286L			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	286					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TTCCTCTGCAGCCCTTCCAGC	0.607000													51	101					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5364396	5364396	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr11:5364396C>T	ENST00000300773.2	-	1	413	c.359G>A	c.(358-360)cGt>cAt	p.R120H	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCAATAAAACGGTCATAGGC	0.473000													35	39					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185190929	185190929	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr3:185190929G>A	ENST00000265026.3	+	11	2144	c.1810G>A	c.(1810-1812)Gca>Aca	p.A604T	MAP3K13_ENST00000446828.1_Missense_Mutation_p.A397T|MAP3K13_ENST00000443863.1_Missense_Mutation_p.A460T|MAP3K13_ENST00000424227.1_Missense_Mutation_p.A604T|MAP3K13_ENST00000535426.1_Missense_Mutation_p.A460T	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	604					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TGACTTTGCCGCAATCTTGAA	0.507000													5	392					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72020942	72020942	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr15:72020942G>T	ENST00000355327.3	+	9	1546	c.1412G>T	c.(1411-1413)cGa>cTa	p.R471L	THSD4_ENST00000357769.4_Missense_Mutation_p.R111L|THSD4_ENST00000261862.6_Missense_Mutation_p.R471L|THSD4_ENST00000567838.1_3'UTR			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	471						proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GCAATTGATCGACCAGGAAAA	0.527000													14	118					4.93089e-13	5.25247e-13	1	1	0
AHI1	54806	broad.mit.edu	37	6	135754276	135754276	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr6:135754276C>T	ENST00000367800.4	-	14	2371	c.2155G>A	c.(2155-2157)Gat>Aat	p.D719N	AHI1_ENST00000417892.2_Missense_Mutation_p.D73N|AHI1_ENST00000457866.2_Missense_Mutation_p.D719N|AHI1_ENST00000327035.6_Missense_Mutation_p.D719N	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	719						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		ATCATGGAATCATAGCATCCT	0.363000													25	67					0	0	1	0	0
PCDHGA6	0	broad.mit.edu	37	5	140754997	140754997	+	Silent	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr5:140754997G>A	ENST00000517434.1	+	1	1347	c.1347G>A	c.(1345-1347)ccG>ccA	p.P449P	PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGACAACCCGCCCACCTTCC	0.512000													6	179					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													5	74					0	0	1	0	0
RASSF1	11186	broad.mit.edu	37	3	50368774	50368774	+	Silent	SNP	C	C	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr3:50368774C>T	ENST00000359365.4	-	5	973	c.867G>A	c.(865-867)ggG>ggA	p.G289G	RASSF1_ENST00000395126.3_Silent_p.G138G|RASSF1_ENST00000357043.2_Silent_p.G293G|RASSF1_ENST00000327761.3_Silent_p.G219G	NM_001206957.1|NM_007182.4|NM_170714.1	NP_001193886.1|NP_009113.3|NP_733832.1	Q9NS23	RASF1_HUMAN	Ras association (RalGDS/AF-6) domain family member 1	293	Ras-associating.				cell cycle arrest|negative regulation of cell cycle arrest|positive regulation of protein ubiquitination|protein stabilization|Ras protein signal transduction|response to DNA damage stimulus	microtubule|microtubule cytoskeleton|microtubule organizing center|nucleus|spindle pole	identical protein binding|protein binding|protein N-terminus binding|zinc ion binding			lung(2)|ovary(1)|skin(1)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000278)|OV - Ovarian serous cystadenocarcinoma(275;0.0015)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CGTTCACCTCCCCAGAGTCAT	0.542000													13	29					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129149824	129149824	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chrX:129149824G>T	ENST00000540052.1	+	3	3120	c.3076G>T	c.(3076-3078)Gtt>Ttt	p.V1026F	BCORL1_ENST00000303743.5_Missense_Mutation_p.V1026F|BCORL1_ENST00000359304.2_Missense_Mutation_p.V1026F|BCORL1_ENST00000218147.7_Missense_Mutation_p.V1026F	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1026					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						ATTGGACGTGGTTCCGAGCAG	0.592000													27	22					2.79863e-10	2.91772e-10	1	1	0
C9orf69	90120	broad.mit.edu	37	9	139008643	139008643	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr9:139008643C>T	ENST00000561457.1	-	2	628	c.178G>A	c.(178-180)Gca>Aca	p.A60T	C9orf69_ENST00000418388.1_Missense_Mutation_p.R35H	NM_152833.2	NP_690046.3			chromosome 9 open reading frame 69											endometrium(1)	1		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.58e-07)|Epithelial(140;6.42e-06)		GTACTTGGTGCGGGCCAGGTG	0.657000													3	46					0	0	1	0	0
MIR940	0	broad.mit.edu	37	16	2321813	2321813	+	RNA	SNP	G	G	A			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr16:2321813G>A	ENST00000401276.1	+	0	66					NR_030636.1																						AAGGAAGGCAGGGCCCCCGCT	0.701000													9	13					0	0	1	0	0
RP11-69E11.4	0	broad.mit.edu	37	1	40011509	40011509	+	RNA	DEL	T	T	-			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr1:40011509delT	ENST00000440190.1	-	0	350																											TGACTAGGCCTTTTTTAGCAG	0.537													2	4	---	---	---	---					
SGIP1	84251	broad.mit.edu	37	1	67109265	67109267	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr1:67109265_67109267delGAA	ENST00000371037.4	+	7	399_401	c.322_324delGAA	c.(322-324)del	p.E112del	SGIP1_ENST00000468286.1_3'UTR|SGIP1_ENST00000371035.3_In_Frame_Del_p.E69del|SGIP1_ENST00000371036.3_In_Frame_Del_p.E87del|SGIP1_ENST00000237247.6_In_Frame_Del_p.E116del|SGIP1_ENST00000371039.1_In_Frame_Del_p.E88del	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	112	Poly-Glu.		E -> Q (in dbSNP:rs17490057).		positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						AAGTGAATCGGAAGAAGAAGAAG	0.345													17	33	---	---	---	---					
DCTN1	1639	broad.mit.edu	37	2	74598294	74598296	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr2:74598294_74598296delCCT	ENST00000361874.3	-	9	970_972	c.653_655delAGG	c.(652-657)gga>g	p.EG218del	DCTN1_ENST00000409240.1_In_Frame_Del_p.EG181del|DCTN1_ENST00000409868.1_In_Frame_Del_p.EG201del|DCTN1_ENST00000409567.3_In_Frame_Del_p.EG198del|DCTN1_ENST00000409438.1_In_Frame_Del_p.EG84del|DCTN1_ENST00000407639.2_In_Frame_Del_p.EG84del|DCTN1_ENST00000394003.3_In_Frame_Del_p.EG211del	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	218					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						GCCCTTAGTCCCTCCTCCTCCTG	0.542													11	347	---	---	---	---					
PIK3CA	5290	broad.mit.edu	37	3	178916938	178916940	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr3:178916938_178916940delGAA	ENST00000263967.3	+	2	482_484	c.325_327delGAA	c.(325-327)del	p.E110del		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	110					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E109del(3)|p.G106_R108del(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGGCAACCGTGAAGAAAAGATCC	0.340		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			41	80	---	---	---	---					
TPD52	7163	broad.mit.edu	37	8	80976789	80976791	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr8:80976789_80976791delTCT	ENST00000379096.5	-	2	171_173	c.57_59delAGA	c.(55-60)gat>ga	p.ED19del	TPD52_ENST00000518937.1_In_Frame_Del_p.ED19del|TPD52_ENST00000448733.2_In_Frame_Del_p.ED59del|TPD52_ENST00000517427.1_In_Frame_Del_p.ED59del|TPD52_ENST00000520527.1_In_Frame_Del_p.ED59del|TPD52_ENST00000537855.1_In_Frame_Del_p.ED59del|TPD52_ENST00000519303.2_5'UTR|TPD52_ENST00000379097.3_In_Frame_Del_p.ED59del	NM_005079.2	NP_005070.1	P55327	TPD52_HUMAN	tumor protein D52	59					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	8	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			GGCAGCAACATCTTCTCCTTCCT	0.448													39	93	---	---	---	---					
ABHD17B	51104	broad.mit.edu	37	9	74489817	74489819	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr9:74489817_74489819delAGA	ENST00000333421.6	-	2	289_291	c.178_180delTCT	c.(178-180)del	p.S60del	ABHD17B_ENST00000377041.2_In_Frame_Del_p.S60del	NM_001025780.1	NP_001020951.1			abhydrolase domain containing 17B																		CTTTTTCTCTAGAAGAATACTGC	0.419													18	145	---	---	---	---					
PRDM12	59335	broad.mit.edu	37	9	133543701	133543702	+	Splice_Site	DEL	GT	GT	-			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr9:133543701_133543702delGT	ENST00000253008.2	+	3	630		c.e3+1			NM_021619.2	NP_067632.2	Q9H4Q4	PRD12_HUMAN	PR domain containing 12						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GGCCATTGAGGTGTGTGTGTGT	0.594													9	88	---	---	---	---					
SURF4	6836	broad.mit.edu	37	9	136230378	136230380	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr9:136230378_136230380delCTT	ENST00000371989.3	-	6	928_930	c.799_801delAAG	c.(799-801)del	p.K267del	SURF4_ENST00000485435.2_Intron|SURF4_ENST00000545297.1_3'UTR	NM_033161.2	NP_149351.1	O15260	SURF4_HUMAN	surfeit 4	267						endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding			kidney(1)|large_intestine(2)|lung(5)	8				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		GTTACCACTCCTTCTTCTTCTCA	0.547													8	50	---	---	---	---					
KRT1	3848	broad.mit.edu	37	12	53069236	53069256	+	In_Frame_Del	DEL	TAGCTGCTACCTCCGGAGCCA	TAGCTGCTACCTCCGGAGCCA	-	rs66529359	by1000genomes	TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr12:53069236_53069256delTAGCTGCTACCTCCGGAGCCA	ENST00000252244.3	-	9	1714_1734	c.1656_1676delTGGCTCCGGAGGTAGCAGCTA	c.(1654-1677)tac>ta	p.YGSGGSSY552del		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	552	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding	p.S557_G563delSSYGSGG(3)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						tccggagccgtagctgctacctccggagccatagctgccac	0.688													4	3	---	---	---	---					
HECTD4	283450	broad.mit.edu	37	12	112605213	112605215	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr12:112605213_112605215delAGA	ENST00000550722.1	-	72	12397_12399	c.12002_12004delTCT	c.(12001-12006)tgg>t	p.FW4001del	HECTD4_ENST00000430131.2_In_Frame_Del_p.FW3725del|HECTD4_ENST00000377560.5_In_Frame_Del_p.FW3975del	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		AGCGTCTTCCAGAAGGAGGGCAG	0.606													10	64	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													4	9	---	---	---	---					
MYH10	4628	broad.mit.edu	37	17	8526520	8526521	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr17:8526520_8526521delAA	ENST00000360416.3	-	2	182_183	c.44_45delTT	c.(43-45)tfs	p.F15fs	MYH10_ENST00000379980.4_Frame_Shift_Del_p.F15fs|MYH10_ENST00000396239.1_Frame_Shift_Del_p.F15fs|MYH10_ENST00000269243.4_Frame_Shift_Del_p.F15fs	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	15	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CCCTGTCCACAAAGAGATACCT	0.480													25	92	---	---	---	---					
HAUS8	93323	broad.mit.edu	37	19	17160706	17160707	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr19:17160706_17160707delGA	ENST00000593360.1	-	10	3044_3045	c.1026_1027delTC	c.(1024-1029)tcgtfs	p.SR342fs	HAUS8_ENST00000253669.5_Frame_Shift_Del_p.SR403fs|HAUS8_ENST00000448593.2_Frame_Shift_Del_p.SR402fs			Q9BT25	HAUS8_HUMAN	HAUS augmin-like complex, subunit 8	403					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)	12						CTCCCTGAACGAGAGAGAGAGG	0.495													7	300	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42791390	42791391	+	Frame_Shift_Ins	INS	-	-	G			TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr19:42791390_42791391insG	ENST00000572681.2	+	4	3245_3246	c.3177_3178insG	c.(3175-3180)gaccttfs	p.DL1059fs	CIC_ENST00000160740.3_Frame_Shift_Ins_p.DL150fs|CIC_ENST00000575354.2_Frame_Shift_Ins_p.DL150fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	150	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				ACCATGATGATGCGTGAGTTCC	0.649			"""Mis, F, S"""		oligodendroglioma								13	7	---	---	---	---					
PIGU	128869	broad.mit.edu	37	20	33225719	33225719	+	Frame_Shift_Del	DEL	G	G	-	rs142228998		TCGA-S9-A6TW-01A-12D-A32B-08	TCGA-S9-A6TW-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17f602fa-959f-4650-bcde-43821303d338	2ec5ceb4-e857-43a2-b7be-0e7a97a37804	g.chr20:33225719delG	ENST00000374820.2	-	4	349	c.329delC	c.(328-330)ctfs	p.P110fs	PIGU_ENST00000452740.2_Frame_Shift_Del_p.P130fs			Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class U	130					attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	9						CATTTCCATAGGGGTCCGGAT	0.423													37	71	---	---	---	---					
