Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KRT83	3889	broad.mit.edu	37	12	52710275	52710275	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr12:52710275C>T	ENST00000293670.3	-	6	1080	c.1018G>A	c.(1018-1020)Gag>Aag	p.E340K		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	340	Coil 2.|Rod.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TTCTCCACCTCGGCTGTCAGC	0.597000													5	75					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000583708.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													5	84					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45502895	45502895	+	Silent	SNP	G	G	A			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr21:45502895G>A	ENST00000291574.4	+	14	2125	c.1950G>A	c.(1948-1950)acG>acA	p.T650T		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	650					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						AGCACAAGACGTCCAATGGGA	0.502000													4	160					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105361169	105361169	+	Silent	SNP	A	A	C			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr14:105361169A>C	ENST00000453495.1	+	19	4875	c.4647A>C	c.(4645-4647)tcA>tcC	p.S1549S	CEP170B_ENST00000556508.1_Silent_p.S1478S|CEP170B_ENST00000418279.1_Silent_p.S1443S|CEP170B_ENST00000414716.3_Silent_p.S1513S					centrosomal protein 170B									p.S1513S(3)|p.S1479S(3)|p.S1478S(1)									GCCCACCCTCACCCGCCTCAG	0.711000													4	12					0	0	1	0	0
C1QTNF9	338872	broad.mit.edu	37	13	24892993	24892993	+	Silent	SNP	G	G	A			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr13:24892993G>A	ENST00000382071.2	+	3	289	c.204G>A	c.(202-204)ggG>ggA	p.G68G	C1QTNF9-AS1_ENST00000449656.1_RNA|C1QTNF9_ENST00000332018.4_Silent_p.G68G			P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	68	Collagen-like 1.					collagen	hormone activity			endometrium(1)|kidney(2)|lung(6)	9		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		GGAAGGATGGGACGAGTGGAG	0.463000													4	43					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31332597	31332597	+	Silent	SNP	G	G	A			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr16:31332597G>A	ENST00000544665.3	+	15	1817	c.1746G>A	c.(1744-1746)caG>caA	p.Q582Q	ITGAM_ENST00000287497.8_Silent_p.Q581Q	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	581					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CCAGGCTCCAGTATTTTGGTC	0.547000													4	125					0	0	1	0	0
GSTT1	2952	broad.mit.edu	37	22	24379404	24379404	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr22:24379404T>C	ENST00000248935.5	-	3	360	c.308A>G	c.(307-309)cAc>cGc	p.H103R	GSTT1_ENST00000439996.2_5'UTR	NM_000853.2	NP_000844.2	P30711	GSTT1_HUMAN	glutathione S-transferase theta 1	103	GST C-terminal.				glutathione metabolic process	cytosol|soluble fraction	glutathione peroxidase activity|glutathione transferase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|ovary(1)|prostate(1)|skin(1)	6					Glutathione(DB00143)	CAGAGTCGTGTGCTGCCATGC	0.607000									Myelodysplasia and Acute Myeloid Leukemia (AML), Familial				4	30					0	0	1	0	0
GNA14	9630	broad.mit.edu	37	9	80043895	80043895	+	Missense_Mutation	SNP	C	C	A			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr9:80043895C>A	ENST00000341700.6	-	5	1164	c.651G>T	c.(649-651)gaG>gaT	p.E217D	GNA14_ENST00000464095.1_5'UTR	NM_004297.3	NP_004288.1	O95837	GNA14_HUMAN	guanine nucleotide binding protein (G protein), alpha 14	217					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	24						AGGTGACACTCTCAAAGCAGT	0.483000													10	120					2.17888e-05	2.24113e-05	1	1	0
XXbac-BPG308J9.3	0	broad.mit.edu	37	6	29231508	29231508	+	RNA	SNP	A	A	G			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr6:29231508A>G	ENST00000441381.1	+	0	79																											GGGTCATATGACATCACAGCC	0.458000													6	196					0	0	1	0	0
CCDC109B	55013	broad.mit.edu	37	4	110603877	110603877	+	Silent	SNP	A	A	G			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr4:110603877A>G	ENST00000394650.4	+	5	724	c.591A>G	c.(589-591)gaA>gaG	p.E197E		NM_017918.4	NP_060388.2	Q9NWR8	C109B_HUMAN	coiled-coil domain containing 109B	197						integral to membrane				breast(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(1)	9				OV - Ovarian serous cystadenocarcinoma(123;6.65e-06)		ACCTGAAGGAACAGCTGCAGC	0.388000													3	61					0	0	1	0	0
GPNMB	10457	broad.mit.edu	37	7	23293803	23293803	+	Missense_Mutation	SNP	C	C	T	rs145407985		TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr7:23293803C>T	ENST00000258733.4	+	3	534	c.239C>T	c.(238-240)gCg>gTg	p.A80V	GPNMB_ENST00000453162.2_Missense_Mutation_p.A80V|GPNMB_ENST00000409458.3_Missense_Mutation_p.A80V|GPNMB_ENST00000381990.2_Missense_Mutation_p.A80V|GPNMB_ENST00000539136.1_Intron			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	80					negative regulation of cell proliferation	melanosome		p.A80V(1)		breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			CGTGTGCAGGCGGTCCTGACC	0.458000													5	109					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98533290	98533290	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr7:98533290C>T	ENST00000359863.4	+	28	4312	c.4103C>T	c.(4102-4104)gCg>gTg	p.A1368V	TRRAP_ENST00000446306.3_Missense_Mutation_p.A1367V|TRRAP_ENST00000355540.3_Missense_Mutation_p.A1368V	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1368					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TTACGAATTGCGGCATTAAGT	0.393000													3	57					0	0	1	0	0
IGF1R	3480	broad.mit.edu	37	15	99465453	99465453	+	Missense_Mutation	SNP	G	G	A	rs70958396		TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr15:99465453G>A	ENST00000268035.6	+	11	2889	c.2278G>A	c.(2278-2280)Gca>Aca	p.A760T	IGF1R_ENST00000558762.1_Missense_Mutation_p.A760T	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	760					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CACCACGGCCGCAGACACCTA	0.527000													3	29					0	0	1	0	0
FAM86HP	0	broad.mit.edu	37	3	129822685	129822685	+	RNA	SNP	G	G	C			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr3:129822685G>C	ENST00000500074.2	-	0	389																											ATCTAAGTTGGCAGTGATGTC	0.567000													5	66					0	0	1	0	0
HS6ST1	9394	broad.mit.edu	37	2	129026421	129026421	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr2:129026421A>G	ENST00000259241.6	-	2	564	c.551T>C	c.(550-552)cTa>cCa	p.L184P		NM_004807.2	NP_004798.3	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	184					heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			endometrium(3)|liver(1)|lung(7)|pancreas(1)|prostate(2)|skin(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		GGGGTCTCGTAGCAGGGTGAT	0.622000													3	38					0	0	1	0	0
USP4	7375	broad.mit.edu	37	3	49335318	49335318	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr3:49335318C>T	ENST00000351842.4	-	12	1543	c.1535G>A	c.(1534-1536)cGg>cAg	p.R512Q	USP4_ENST00000265560.4_Missense_Mutation_p.R559Q	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	559					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		AATGTCATCCCGAGGCATGAT	0.418000													6	72					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22861861	22861861	+	Silent	SNP	G	G	A			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr15:22861861G>A	ENST00000283645.4	+	14	2011	c.1881G>A	c.(1879-1881)aaG>aaA	p.K627K	TUBGCP5_ENST00000559846.1_3'UTR|TUBGCP5_ENST00000453949.2_Silent_p.K627K	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	627					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		ACCTGATGAAGATGCAGTCCA	0.468000													6	171					0	0	1	0	0
GLUD2	2747	broad.mit.edu	37	X	120182972	120182972	+	Silent	SNP	T	T	C			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chrX:120182972T>C	ENST00000328078.1	+	1	1511	c.1434T>C	c.(1432-1434)ttT>ttC	p.F478F		NM_012084.3	NP_036216.2	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	478					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	AAAGAAAATTTGGAAAGCATG	0.428000													14	70					0	0	1	0	0
IDH2	3418	broad.mit.edu	37	15	90631838	90631838	+	Missense_Mutation	SNP	C	C	A	rs121913503		TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr15:90631838C>A	ENST00000330062.3	-	4	628	c.515G>T	c.(514-516)aGg>aTg	p.R172M	IDH2_ENST00000539790.1_Missense_Mutation_p.R42M|IDH2_ENST00000540499.2_Missense_Mutation_p.R120M|IDH2_ENST00000559482.1_Intron	NM_002168.2	NP_002159.2	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+), mitochondrial	172					2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding	p.R172K(116)|p.R172M(21)|p.R172N(1)		biliary_tract(11)|bone(19)|central_nervous_system(107)|endometrium(1)|haematopoietic_and_lymphoid_tissue(953)|large_intestine(8)|lung(5)|skin(5)	1109	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			ATGGGCGTGCCTGCCAATGGT	0.632000			M		GBM								9	35					2.74318e-10	2.90454e-10	1	1	0
UBR3	130507	broad.mit.edu	37	2	170863700	170863700	+	Splice_Site	SNP	A	A	G			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr2:170863700A>G	ENST00000272793.5	+	28	4280	c.4230_splice	c.e28+1	p.P1410_splice	UBR3_ENST00000418381.1_Splice_Site_p.P1410_splice|UBR3_ENST00000392631.1_Splice_Site_p.P231_splice			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1410					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						GAGCTTTCCCAGTAAGCATCA	0.403000													3	7					0	0	1	0	0
RTN4RL2	349667	broad.mit.edu	37	11	57243804	57243804	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr11:57243804G>A	ENST00000335099.3	+	3	1000	c.683G>A	c.(682-684)cGc>cAc	p.R228H		NM_178570.1	NP_848665.1	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2	228					axon regeneration	anchored to plasma membrane	receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(2)	6						GGCCTCAGCCGCCTCACCATC	0.701000													4	40					0	0	1	0	0
OR4L1	122742	broad.mit.edu	37	14	20528495	20528495	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr14:20528495G>A	ENST00000315683.1	+	1	292	c.292G>A	c.(292-294)Gtg>Atg	p.V98M		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		GTGGGGCTGCGTGACCCAGAT	0.468000													24	148					0	0	1	0	0
TRBC2	0	broad.mit.edu	37	7	142498903	142498903	+	RNA	SNP	G	G	A	rs1062612		TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr7:142498903G>A	ENST00000466254.1	+	0	179																											GCACAGACCCGCAGCCCCTCA	0.647000													4	106					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16360693	16360693	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr20:16360693G>A	ENST00000354981.2	-	19	2111	c.1954C>T	c.(1954-1956)Cgc>Tgc	p.R652C	KIF16B_ENST00000408042.1_Missense_Mutation_p.R652C|KIF16B_ENST00000355755.3_Missense_Mutation_p.R652C|KIF16B_ENST00000378003.2_5'UTR	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	652	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						TCCTGCTTGCGAATCTGGAGC	0.517000													6	130					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr16:90162513T>C	ENST00000567960.1	+	0	1249				TUBB8P7_ENST00000564451.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													4	133					0	0	1	0	0
BRD2	6046	broad.mit.edu	37	6	32944712	32944712	+	Splice_Site	SNP	A	A	G			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr6:32944712A>G	ENST00000395289.2	+	7	2800	c.1200_splice	c.e7+1	p.K400_splice	BRD2_ENST00000374831.4_Splice_Site_p.K400_splice|BRD2_ENST00000374825.4_Splice_Site_p.K400_splice|BRD2_ENST00000395287.1_Splice_Site_p.K400_splice|BRD2_ENST00000449085.2_Splice_Site_p.K353_splice|BRD2_ENST00000443797.2_Splice_Site_p.K280_splice			P25440	BRD2_HUMAN	bromodomain containing 2	400	Bromo 2.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						AGCACTGTCAAGGTACCCACT	0.512000													7	30					0	0	1	0	0
GGT3P	0	broad.mit.edu	37	22	18769145	18769145	+	RNA	SNP	G	G	A			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr22:18769145G>A	ENST00000412448.1	-	0	1141																											TGAGGCTGCCGTTGTAGAAGG	0.612000													3	20					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5428871	5428871	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr7:5428871delG	ENST00000399537.4	-	5	932	c.584delC	c.(583-585)cgfs	p.P195fs	TNRC18_ENST00000430969.1_Frame_Shift_Del_p.P195fs			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	195							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GCCTTTGGCCGGGGCGCCCGA	0.776													2	4	---	---	---	---					
HMX3	340784	broad.mit.edu	37	10	124895699	124895699	+	Frame_Shift_Del	DEL	C	C	-			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr10:124895699delC	ENST00000357878.5	+	1	222	c.133delC	c.(133-135)ccfs	p.P46fs		NM_001105574.1	NP_001099044.1	A6NHT5	HMX3_HUMAN	H6 family homeobox 3	46	Pro-rich.				cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity			lung(4)	4		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.122)|COAD - Colon adenocarcinoma(40;0.141)		CCACCGGCCGCCCCCTAAGCC	0.766													2	4	---	---	---	---					
ROBO3	64221	broad.mit.edu	37	11	124750448	124750453	+	In_Frame_Del	DEL	CGGAGT	CGGAGT	-	rs55725290		TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr11:124750448_124750453delCGGAGT	ENST00000397801.1	+	27	4285_4290	c.4093_4098delCGGAGT	c.(4093-4098)del	p.RS1367del	ROBO3_ENST00000525482.1_3'UTR|ROBO3_ENST00000543966.1_In_Frame_Del_p.RS130del|ROBO3_ENST00000538940.1_In_Frame_Del_p.RS1345del	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1367					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		TGgccggagccggagtcggagtcaga	0.660													4	7	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124887093	124887094	+	In_Frame_Ins	INS	-	-	TGT			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr12:124887093_124887094insTGT	ENST00000356219.3	-	15	1651_1652	c.1496_1497insACA	c.(1495-1497)cca>cACAca	p.499_499P>HT	NCOR2_ENST00000429285.2_In_Frame_Ins_p.498_498P>HT|NCOR2_ENST00000404621.1_In_Frame_Ins_p.498_498P>HT|NCOR2_ENST00000404121.2_In_Frame_Ins_p.69_69P>HT|NCOR2_ENST00000397355.1_In_Frame_Ins_p.499_499P>HT|NCOR2_ENST00000405201.1_In_Frame_Ins_p.499_499P>HT	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	499	Poly-Gln.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity	p.Q499Q(9)		breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		gctgctgctgctgttgttgctg	0.619													2	4	---	---	---	---					
RP11-536C10.7	0	broad.mit.edu	37	14	19408019	19408019	+	RNA	DEL	A	A	-			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr14:19408019delA	ENST00000548050.1	-	0	279					NR_046104.1																						CTGTGGAGCCAAAAAAAAAAT	0.393													2	4	---	---	---	---					
FHOD3	80206	broad.mit.edu	37	18	34261459	34261460	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-TM-A84R-01A-21D-A36O-08	TCGA-TM-A84R-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be058c4c-ac5b-4de5-8182-93cefb089168	e7293682-ad76-4f1e-97f8-59ef2d8fd64a	g.chr18:34261459_34261460delAG	ENST00000257209.4	+	12	1493_1494	c.1371_1372delAG	c.(1369-1374)gcagfs	p.AE457fs	FHOD3_ENST00000590592.1_Frame_Shift_Del_p.AE632fs|FHOD3_ENST00000359247.4_Frame_Shift_Del_p.AE457fs|FHOD3_ENST00000445677.1_Frame_Shift_Del_p.AE419fs|FHOD3_ENST00000591635.1_Intron	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	457					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CACTGGCAGCAGAGAGAGAGAG	0.460													7	62	---	---	---	---					
