Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBXN4	23190	broad.mit.edu	37	2	136511791	136511791	+	Missense_Mutation	SNP	A	A	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr2:136511791A>C	ENST00000272638.9	+	4	588	c.277A>C	c.(277-279)Ata>Cta	p.I93L	UBXN4_ENST00000490163.1_3'UTR	NM_014607.3	NP_055422.1	Q92575	UBXN4_HUMAN	UBX domain protein 4	93					response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	24						CTTGGAAGTAATAGCAGGAAG	0.403000													41	105					0	0	0.131918	0	0
RBM28	55131	broad.mit.edu	37	7	127964664	127964664	+	Silent	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr7:127964664C>T	ENST00000223073.1	-	12	1401	c.1287G>A	c.(1285-1287)acG>acA	p.T429T	RBM28_ENST00000415472.2_Silent_p.T288T	NM_018077.2	NP_060547.2	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	429					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			breast(1)|kidney(7)|large_intestine(3)|lung(8)|ovary(2)	21						TCTTCACCTTCGTCGTCTGAA	0.562000													85	226					0	0	0.139131	0	0
MC5R	4161	broad.mit.edu	37	18	13826628	13826628	+	Silent	SNP	C	C	T	rs142287236	byFrequency	TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr18:13826628C>T	ENST00000324750.3	+	1	1086	c.864C>T	c.(862-864)tcC>tcT	p.S288S		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	288					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						TGTGTAATTCCGTGATGGACC	0.463000													45	125					0	0	0.139131	0	0
LRIG2	9860	broad.mit.edu	37	1	113661909	113661909	+	Missense_Mutation	SNP	A	A	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr1:113661909A>T	ENST00000361127.4	+	17	2933	c.2735A>T	c.(2734-2736)tAc>tTc	p.Y912F	LRIG2_ENST00000492207.1_3'UTR	NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	912						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		GCCAACATCTACTCCAGGACC	0.423000													13	112					0	0	0.105934	0	0
MAML3	55534	broad.mit.edu	37	4	140811971	140811971	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr4:140811971G>A	ENST00000509479.2	-	2	1475	c.619C>T	c.(619-621)Ccc>Tcc	p.P207S	MAML3_ENST00000327122.5_Missense_Mutation_p.P51S	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	207					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					ATGTTACTGGGCAAATTGTTG	0.488000													3	54					0	0	0.115264	0	0
CORO1A	11151	broad.mit.edu	37	16	30198794	30198794	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr16:30198794G>A	ENST00000219150.5	+	6	1033	c.728G>A	c.(727-729)aGt>aAt	p.S243N	CORO1A_ENST00000565497.1_Missense_Mutation_p.S243N|CORO1A_ENST00000570045.1_Missense_Mutation_p.S243N	NM_001193333.2|NM_007074.3	NP_001180262.1|NP_009005.1	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	243					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	9						AGCCGCATGAGTGAGCGGCAG	0.667000													3	16					0	0	0.150653	0	0
PAXBP1	94104	broad.mit.edu	37	21	34136826	34136826	+	Missense_Mutation	SNP	G	G	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr21:34136826G>T	ENST00000331923.4	-	3	671	c.482C>A	c.(481-483)cCt>cAt	p.P161H	PAXBP1_ENST00000290178.4_Missense_Mutation_p.P161H|PAXBP1_ENST00000472588.1_5'UTR	NM_016631.3	NP_057715.2			PAX3 and PAX7 binding protein 1																		TTTGTCCAAAGGTTGTTCACC	0.269000													22	36					5.45024e-15	6.13869e-15	0.083992	1	0
FLT1	2321	broad.mit.edu	37	13	29001360	29001360	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr13:29001360C>T	ENST00000282397.4	-	10	1623	c.1372G>A	c.(1372-1374)Ggt>Agt	p.G458S	FLT1_ENST00000539099.1_Missense_Mutation_p.G458S|FLT1_ENST00000541932.1_Missense_Mutation_p.G458S	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	458	Ig-like C2-type 5.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TGAGGGATACCATATGCGGTA	0.468000													39	82					0	0	0.098360	0	0
SCN11A	11280	broad.mit.edu	37	3	38950499	38950499	+	Missense_Mutation	SNP	C	C	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr3:38950499C>G	ENST00000302328.3	-	9	1486	c.1288G>C	c.(1288-1290)Gag>Cag	p.E430Q	SCN11A_ENST00000456224.3_Missense_Mutation_p.E430Q|SCN11A_ENST00000450244.1_Missense_Mutation_p.E430Q|SCN11A_ENST00000444237.2_Missense_Mutation_p.E430Q	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	430					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCCTTTTCCTCCTTTAACAGC	0.537000													3	126					0	0	0.115264	0	0
FLI1	2313	broad.mit.edu	37	11	128680431	128680431	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr11:128680431G>A	ENST00000344954.6	+	9	1196	c.808G>A	c.(808-810)Gag>Aag	p.E270K	FLI1_ENST00000525560.1_Missense_Mutation_p.E110K|FLI1_ENST00000281428.8_Missense_Mutation_p.E237K|FLI1_ENST00000429175.2_Missense_Mutation_p.E303K|FLI1_ENST00000534087.1_Missense_Mutation_p.E270K			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	303					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		TATCACCTGGGAGGGGACCAA	0.617000			T	EWSR1	Ewing sarcoma								5	7					0	0	0.217242	0	0
OR11H4	390442	broad.mit.edu	37	14	20711760	20711760	+	Silent	SNP	A	A	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr14:20711760A>T	ENST00000315409.2	+	1	863	c.810A>T	c.(808-810)gtA>gtT	p.V270V		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		TAATGTATGTAAGTCCTACAT	0.423000													50	196					0	0	0.139131	0	0
RAI14	26064	broad.mit.edu	37	5	34757654	34757654	+	Missense_Mutation	SNP	G	G	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr5:34757654G>C	ENST00000265109.3	+	3	405	c.118G>C	c.(118-120)Ggc>Cgc	p.G40R	RAI14_ENST00000428746.2_Missense_Mutation_p.G40R|RAI14_ENST00000397449.1_Missense_Mutation_p.G33R|RAI14_ENST00000507276.1_3'UTR|RAI14_ENST00000506376.1_Missense_Mutation_p.G32R|RAI14_ENST00000503673.1_Missense_Mutation_p.G40R|RAI14_ENST00000515799.1_Missense_Mutation_p.G43R|RAI14_ENST00000512629.1_Missense_Mutation_p.G40R	NM_001145522.1|NM_015577.2	NP_001138994.1|NP_056392.2	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14	40						cell cortex|cytoskeleton	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(19)|lung(22)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(31;0.000191)					CTCACTGCTCGGCAAGAAGGG	0.537000													18	50					0	0	0.160694	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	71					0	0	0.115264	0	0
DXO	1797	broad.mit.edu	37	6	31938839	31938839	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr6:31938839C>T	ENST00000375349.3	-	3	853	c.442G>A	c.(442-444)Ggc>Agc	p.G148S	DOM3Z_ENST00000375356.3_Missense_Mutation_p.G148S|DOM3Z_ENST00000337523.5_Missense_Mutation_p.G148S|DOM3Z_ENST00000478221.1_5'UTR			O77932	DOM3Z_HUMAN		148							identical protein binding|metal ion binding|nucleotide binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	7						AGCTGCCAGCCCTCCTGCCGC	0.647000													29	78					0	0	0.163468	0	0
ZDHHC2	51201	broad.mit.edu	37	8	17067900	17067900	+	Silent	SNP	A	A	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr8:17067900A>G	ENST00000262096.8	+	10	1556	c.861A>G	c.(859-861)ctA>ctG	p.L287L		NM_016353.4	NP_057437.1	Q9UIJ5	ZDHC2_HUMAN	zinc finger, DHHC-type containing 2	287						integral to membrane	acyltransferase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|pancreas(1)|stomach(1)	8				Colorectal(111;0.0697)|COAD - Colon adenocarcinoma(73;0.244)		ATTCTAGTCTAGGTGATGGCT	0.413000													6	31					0	0	0.217242	0	0
OR6F1	343169	broad.mit.edu	37	1	247875312	247875312	+	Missense_Mutation	SNP	A	A	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr1:247875312A>G	ENST00000302084.2	-	1	793	c.746T>C	c.(745-747)cTc>cCc	p.L249P	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			ATACCAAATGAGCACCACGGT	0.537000													42	83					0	0	0.104719	0	0
SEC14L5	9717	broad.mit.edu	37	16	5040783	5040783	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr16:5040783G>A	ENST00000251170.7	+	5	541	c.361G>A	c.(361-363)Gaa>Aaa	p.E121K		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	121	PRELI/MSF1.					integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						CCCTGAGAATGAAGACTGGAC	0.582000													14	28					0	0	0.146539	0	0
F9	2158	broad.mit.edu	37	X	138644198	138644198	+	Missense_Mutation	SNP	A	A	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chrX:138644198A>C	ENST00000218099.2	+	8	1361	c.1354A>C	c.(1354-1356)Aac>Cac	p.N452H	F9_ENST00000394090.2_Missense_Mutation_p.N414H	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	452	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	CCGGTATGTCAACTGGATTAA	0.373000													22	23					0	0	0.076483	0	0
C12orf76	400073	broad.mit.edu	37	12	110511326	110511326	+	Translation_Start_Site	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr12:110511326C>T	ENST00000548191.1	-	0	165				C12orf76_ENST00000548936.1_5'UTR			Q8N812	CL076_HUMAN	chromosome 12 open reading frame 76											endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6						GAAAACATCACTGCAGCTGCA	0.552000													6	10					0	0	0.029380	0	0
PNMA1	9240	broad.mit.edu	37	14	74179538	74179538	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr14:74179538C>T	ENST00000316836.3	-	1	1590	c.805G>A	c.(805-807)Gag>Aag	p.E269K		NM_006029.4	NP_006020.4	Q8ND90	PNMA1_HUMAN	paraneoplastic Ma antigen 1	269					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|urinary_tract(2)	13				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		agcagaggctccagacgaatg	0.517000													20	43					0	0	0.189662	0	0
SLC12A2	6558	broad.mit.edu	37	5	127484471	127484471	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr5:127484471C>T	ENST00000262461.2	+	12	2096	c.1907C>T	c.(1906-1908)cCa>cTa	p.P636L	SLC12A2_ENST00000343225.4_Missense_Mutation_p.P636L	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	636					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	AACATCTACCCAGCTTTCCAG	0.323000													46	215					0	0	0.139131	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811159	140811159	+	Missense_Mutation	SNP	G	G	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr5:140811159G>T	ENST00000252085.3	+	1	975	c.833G>T	c.(832-834)aGg>aTg	p.R278M	PCDHGA11_ENST00000398587.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGAAGTGAGGTATTCCTTC	0.542000													44	114					3.61848e-18	4.20845e-18	0.098360	1	0
TJP1	7082	broad.mit.edu	37	15	30026551	30026551	+	Silent	SNP	T	T	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr15:30026551T>C	ENST00000346128.6	-	12	1917	c.1443A>G	c.(1441-1443)gaA>gaG	p.E481E	TJP1_ENST00000400011.2_Silent_p.E485E|TJP1_ENST00000356107.6_Silent_p.E481E|TJP1_ENST00000545208.2_Silent_p.E481E	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	481	PDZ 3.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GGACGGCTTCTTCTCTTATGA	0.368000													10	147					0	0	0.069234	0	0
SP140L	93349	broad.mit.edu	37	2	231193481	231193481	+	Missense_Mutation	SNP	C	C	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr2:231193481C>G	ENST00000243810.6	+	2	42	c.42C>G	c.(40-42)aaC>aaG	p.N14K	SP140L_ENST00000444636.1_Missense_Mutation_p.N14K|SP140L_ENST00000415673.2_Missense_Mutation_p.N14K|SP140_ENST00000486687.2_Intron|SP140L_ENST00000396563.4_Missense_Mutation_p.N14K			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	14						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						gggggctgaacggaggtgttt	0.378000													11	32					0	0	0.069234	0	0
HSPA12B	116835	broad.mit.edu	37	20	3728984	3728984	+	Missense_Mutation	SNP	C	C	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr20:3728984C>A	ENST00000254963.2	+	8	941	c.796C>A	c.(796-798)Cca>Aca	p.P266T	HSPA12B_ENST00000542646.1_Missense_Mutation_p.P100T	NM_001197327.1|NM_052970.4	NP_001184256.1|NP_443202.3	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	266							ATP binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	14						TGGCCGGGCCCCAGGTGGTGG	0.701000													12	31					4.3838e-07	4.73805e-07	0.105934	1	0
FAM196A	642938	broad.mit.edu	37	10	128974642	128974642	+	Silent	SNP	G	G	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr10:128974642G>T	ENST00000522781.1	-	4	573	c.18C>A	c.(16-18)acC>acA	p.T6T	DOCK1_ENST00000280333.6_Intron|FAM196A_ENST00000424811.2_Silent_p.T6T	NM_001039762.2	NP_001034851.1	Q6ZSG2	F196A_HUMAN	family with sequence similarity 196, member A	6										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						TGCATTTGCCGGTGTCCTTAC	0.537000													26	113					2.79863e-10	3.05565e-10	0.099896	1	0
ARHGEF17	9828	broad.mit.edu	37	11	73071410	73071410	+	Missense_Mutation	SNP	G	G	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr11:73071410G>C	ENST00000263674.3	+	11	4602	c.4252G>C	c.(4252-4254)Gac>Cac	p.D1418H		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1418					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						CATGCACCGGGACCTGTCGGA	0.657000													18	104					0	0	0.175082	0	0
HYDIN	54768	broad.mit.edu	37	16	70934968	70934968	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr16:70934968C>T	ENST00000393567.2	-	53	9137	c.8987G>A	c.(8986-8988)gGc>gAc	p.G2996D		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2996										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CAGGTGCAGGCCGTACTCAGC	0.557000													39	122					0	0	0.124865	0	0
DTX1	1840	broad.mit.edu	37	12	113496211	113496211	+	Missense_Mutation	SNP	T	T	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr12:113496211T>C	ENST00000257600.3	+	1	717	c.214T>C	c.(214-216)Tac>Cac	p.Y72H		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	72	WWE 1.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						GCTTGTGCCCTACATCATCGA	0.642000													3	133					0	0	0.184627	0	0
TAC3	6866	broad.mit.edu	37	12	57409500	57409500	+	Nonsense_Mutation	SNP	C	C	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr12:57409500C>A	ENST00000458521.2	-	2	241	c.82G>T	c.(82-84)Gag>Tag	p.E28*	TAC3_ENST00000441881.1_Nonsense_Mutation_p.E28*|TAC3_ENST00000415231.1_Nonsense_Mutation_p.E28*	NM_013251.3	NP_037383.1	Q9UHF0	TKNK_HUMAN	tachykinin 3	28					female pregnancy|neuropeptide signaling pathway|tachykinin receptor signaling pathway	extracellular space|soluble fraction	receptor binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						ACCACCTCCTCCTGTGGCTCC	0.597000													31	83					5.60225e-13	6.24417e-13	0.144211	1	0
OR2Y1	134083	broad.mit.edu	37	5	180166493	180166493	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr5:180166493G>A	ENST00000307832.2	-	1	606	c.566C>T	c.(565-567)gCg>gTg	p.A189V		NM_001001657.1	NP_001001657.1	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y, member 1	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCTGTGTCCGCACAAGCCAA	0.507000													4	112					0	0	0.184627	0	0
CHTF18	63922	broad.mit.edu	37	16	840647	840647	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr16:840647C>T	ENST00000317063.6	+	8	1460	c.1460C>T	c.(1459-1461)aCg>aTg	p.T487M	CHTF18_ENST00000491530.1_3'UTR|CHTF18_ENST00000262315.9_Missense_Mutation_p.T292M|CHTF18_ENST00000455171.2_Missense_Mutation_p.T320M			Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	292					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			endometrium(1)|kidney(3)|liver(2)|lung(4)|prostate(1)	11		Hepatocellular(780;0.00335)				CGCCACTACACGGAGCTGCTC	0.597000													3	17					0	0	0.150653	0	0
PI4KB	5298	broad.mit.edu	37	1	151288321	151288321	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr1:151288321C>T	ENST00000368875.2	-	3	1253	c.673G>A	c.(673-675)Gcc>Acc	p.A225T	PI4KB_ENST00000271657.5_Missense_Mutation_p.A225T|PI4KB_ENST00000368873.1_Missense_Mutation_p.A213T|PI4KB_ENST00000368874.4_Missense_Mutation_p.A213T|PI4KB_ENST00000529142.1_Intron|PI4KB_ENST00000368872.1_Missense_Mutation_p.A213T	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	213					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGCAACAGGGCACACTGGAGG	0.507000													21	47					0	0	0.076483	0	0
POMT1	10585	broad.mit.edu	37	9	134385344	134385344	+	Silent	SNP	C	C	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr9:134385344C>G	ENST00000423007.1	+	8	1102	c.660C>G	c.(658-660)gtC>gtG	p.V220V	POMT1_ENST00000402686.3_Silent_p.V220V|POMT1_ENST00000354713.4_Silent_p.V190V|POMT1_ENST00000404875.2_Silent_p.V103V|POMT1_ENST00000341012.7_Silent_p.V166V|POMT1_ENST00000372228.3_Silent_p.V220V|POMT1_ENST00000541219.1_Intron|POMT1_ENST00000419118.2_Silent_p.V68V	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	220					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TTGCAGCTGTCCATGCCTGGC	0.522000													45	84					0	0	0.139131	0	0
EFCAB6	64800	broad.mit.edu	37	22	43972202	43972202	+	Missense_Mutation	SNP	T	T	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr22:43972202T>G	ENST00000262726.7	-	26	3648	c.3395A>C	c.(3394-3396)cAg>cCg	p.Q1132P	EFCAB6_ENST00000396231.2_Missense_Mutation_p.Q980P	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GCTAAAGTTCTGGAGAAAATA	0.313000													19	50					0	0	0.076483	0	0
TSTD2	158427	broad.mit.edu	37	9	100380108	100380108	+	Silent	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr9:100380108G>A	ENST00000341170.4	-	4	916	c.534C>T	c.(532-534)gaC>gaT	p.D178D	TSTD2_ENST00000375163.1_5'UTR|TSTD2_ENST00000375172.2_5'UTR|TSTD2_ENST00000375165.1_5'UTR|TSTD2_ENST00000484708.1_5'UTR|TSTD2_ENST00000354801.2_5'UTR	NM_139246.4	NP_640339.4	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like domain containing 2	178										large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	15						GATCCTCCAGGTCATGGTAGC	0.498000													6	65					0	0	0.029380	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117789550	117789550	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr11:117789550C>T	ENST00000528626.1	-	2	98	c.25G>A	c.(25-27)Gca>Aca	p.A9T	TMPRSS13_ENST00000524993.1_Missense_Mutation_p.A9T|TMPRSS13_ENST00000526090.1_Missense_Mutation_p.A9T|TMPRSS13_ENST00000430170.2_Missense_Mutation_p.A9T|TMPRSS13_ENST00000445164.2_Missense_Mutation_p.A9T	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	9	12 X 5 AA repeats of A-S-P-A-[GLQR].|Ala-rich.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		GCTGGAGATGCATTCTGAAAG	0.602000													3	40					0	0	0.115264	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43625455	43625455	+	Missense_Mutation	SNP	T	T	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr9:43625455T>C	ENST00000332857.6	-	4	3260	c.3232A>G	c.(3232-3234)Aaa>Gaa	p.K1078E		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		TGCACCAGTTTGCTCCTTCTG	0.532000													46	284					0	0	0.139131	0	0
NUP153	9972	broad.mit.edu	37	6	17706532	17706532	+	Nonsense_Mutation	SNP	G	G	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr6:17706532G>C	ENST00000262077.2	-	1	86	c.87C>G	c.(85-87)taC>taG	p.Y29*	NUP153_ENST00000537253.1_Nonsense_Mutation_p.Y29*|RP11-500C11.3_ENST00000606771.1_RNA	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	29					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GCCCCTGCTGGTAAGGCTTAA	0.721000													13	24					0	0	0.132662	0	0
HMMR	3161	broad.mit.edu	37	5	162910059	162910059	+	Silent	SNP	A	A	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr5:162910059A>G	ENST00000416990.2	+	14	1718	c.1221A>G	c.(1219-1221)ctA>ctG	p.L407L	HMMR_ENST00000358715.3_Silent_p.L521L|HMMR_ENST00000393915.4_Silent_p.L522L|HMMR_ENST00000432118.2_Silent_p.L435L|HMMR_ENST00000353866.3_Silent_p.L506L			O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor (RHAMM)	521						cell surface|cytoplasm	hyaluronic acid binding			cervix(1)|kidney(3)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	23	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		AGTCAGCACTAAAGGAAACAG	0.343000													33	134					0	0	0.163468	0	0
QRICH2	84074	broad.mit.edu	37	17	74278089	74278089	+	Silent	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr17:74278089G>A	ENST00000262765.5	-	8	3800	c.3621C>T	c.(3619-3621)atC>atT	p.I1207I		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1207							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						CCTCAGGGTCGATCTGGCCAG	0.612000													4	29					0	0	0.150653	0	0
ALG13	79868	broad.mit.edu	37	X	110996020	110996020	+	Missense_Mutation	SNP	A	A	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chrX:110996020A>G	ENST00000394780.3	+	25	2947	c.2935A>G	c.(2935-2937)Aca>Gca	p.T979A	ALG13_ENST00000251943.4_Missense_Mutation_p.T796A|ALG13_ENST00000470971.1_3'UTR	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	979					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity	p.T796S(1)|p.T301S(1)|p.T979S(1)		endometrium(2)|lung(10)|skin(1)	13						AATTTTAGATACAAAAGTTTT	0.323000													9	9					0	0	0.047766	0	0
ZNF563	147837	broad.mit.edu	37	19	12429410	12429410	+	Nonstop_Mutation	SNP	A	A	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr19:12429410A>C	ENST00000293725.5	-	4	1634	c.1429T>G	c.(1429-1431)Tga>Gga	p.*477G		NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						GTTTACATTCATATTGTTTCT	0.363000													37	51					0	0	0.214465	0	0
SNHG14	104472715	broad.mit.edu	37	15	25332980	25332980	+	RNA	SNP	A	A	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr15:25332980A>G	ENST00000546682.1	+	0	586				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						GCGTCTGTTCAGGCTTAGAAT	0.498000													3	59					0	0	0.115264	0	0
AHNAK	79026	broad.mit.edu	37	11	62291579	62291579	+	Missense_Mutation	SNP	C	C	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr11:62291579C>G	ENST00000378024.4	-	5	10584	c.10310G>C	c.(10309-10311)gGt>gCt	p.G3437A	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3437					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TAAATTGGGACCTGCAATATC	0.418000													20	71					0	0	0.189662	0	0
XPO7	23039	broad.mit.edu	37	8	21844736	21844736	+	Missense_Mutation	SNP	T	T	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr8:21844736T>G	ENST00000434536.1	+	14	1791	c.1689T>G	c.(1687-1689)ttT>ttG	p.F563L	XPO7_ENST00000433566.4_Missense_Mutation_p.F555L|XPO7_ENST00000252512.9_Missense_Mutation_p.F554L			Q9UIA9	XPO7_HUMAN	exportin 7	554					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		TGAGCTTTTTTGAACAGTTTC	0.493000													39	79					0	0	0.098360	0	0
HCFC1	3054	broad.mit.edu	37	X	153223256	153223256	+	Missense_Mutation	SNP	C	C	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chrX:153223256C>G	ENST00000310441.7	-	12	3076	c.2110G>C	c.(2110-2112)Ggt>Cgt	p.G704R	HCFC1_ENST00000369984.4_Missense_Mutation_p.G704R|HCFC1_ENST00000354233.3_Missense_Mutation_p.G635R	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	704	Interaction with SIN3A.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTCACAGGACCCGTGGACGCC	0.552000													25	18					0	0	0.108266	0	0
ZNF202	7753	broad.mit.edu	37	11	123597460	123597460	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr11:123597460C>T	ENST00000336139.4	-	8	1554	c.1192G>A	c.(1192-1194)Gac>Aac	p.D398N	ZNF202_ENST00000530393.1_Missense_Mutation_p.D398N|ZNF202_ENST00000529691.1_Missense_Mutation_p.D398N			O95125	ZN202_HUMAN	zinc finger protein 202	398					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		ACAGAACAGTCATGATGCCTC	0.433000													43	83					0	0	0.124865	0	0
LAMA3	3909	broad.mit.edu	37	18	21470025	21470025	+	Missense_Mutation	SNP	A	A	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr18:21470025A>G	ENST00000313654.9	+	42	5595	c.5354A>G	c.(5353-5355)cAa>cGa	p.Q1785R	LAMA3_ENST00000399516.3_Missense_Mutation_p.Q1785R|LAMA3_ENST00000587184.1_Missense_Mutation_p.Q176R|LAMA3_ENST00000269217.6_Missense_Mutation_p.Q176R	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1785	Domain III A.|Laminin EGF-like 14.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTAGCTGCCAACCATGCAGT	0.498000													40	126					0	0	0.111260	0	0
TKT	7086	broad.mit.edu	37	3	53262142	53262142	+	Missense_Mutation	SNP	G	G	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr3:53262142G>T	ENST00000462138.1	-	12	1591	c.1503C>A	c.(1501-1503)gaC>gaA	p.D501E	TKT_ENST00000423516.1_Missense_Mutation_p.D509E|TKT_ENST00000461139.1_5'UTR|TKT_ENST00000423525.2_Missense_Mutation_p.D501E|TKT_ENST00000296289.6_Missense_Mutation_p.D454E			P29401	TKT_HUMAN	transketolase	501					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			endometrium(5)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	CGGTCACCTGGTCATCCTTGC	0.622000													21	25					3.8784e-16	4.46225e-16	0.234183	1	0
CDK5R2	8941	broad.mit.edu	37	2	219825193	219825193	+	Silent	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr2:219825193C>T	ENST00000302625.4	+	1	817	c.651C>T	c.(649-651)gaC>gaT	p.D217D	AC097468.7_ENST00000429343.1_RNA	NM_003936.4	NP_003927.1	Q13319	CD5R2_HUMAN	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	217					regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase 5 holoenzyme complex	cyclin-dependent protein kinase 5 activator activity			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	8		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCGGTGTGGACCGCTCGCTGC	0.672000													19	52					0	0	0.204396	0	0
DCST2	127579	broad.mit.edu	37	1	155004243	155004243	+	Silent	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr1:155004243C>T	ENST00000368424.3	-	4	604	c.546G>A	c.(544-546)agG>agA	p.R182R	DCST2_ENST00000295536.5_Silent_p.R182R	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	182						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TCCGGAGAGCCCTGGCTGGGG	0.582000													3	26					0	0	0.184627	0	0
NSD1	64324	broad.mit.edu	37	5	176684057	176684057	+	Missense_Mutation	SNP	C	C	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr5:176684057C>A	ENST00000439151.2	+	13	4916	c.4871C>A	c.(4870-4872)cCa>cAa	p.P1624Q	NSD1_ENST00000347982.4_Missense_Mutation_p.P1355Q|NSD1_ENST00000354179.4_Missense_Mutation_p.P1355Q|NSD1_ENST00000361032.4_Missense_Mutation_p.P1521Q	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1624					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CAGAAGTACCCACCCACTGTT	0.458000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			36	99					1.90571e-15	2.16926e-15	0.203993	1	0
CSMD1	64478	broad.mit.edu	37	8	3224564	3224564	+	Silent	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr8:3224564G>A	ENST00000520002.1	-	21	3663	c.3108C>T	c.(3106-3108)atC>atT	p.I1036I	CSMD1_ENST00000602723.1_Silent_p.I1036I|CSMD1_ENST00000400186.3_Silent_p.I1036I|CSMD1_ENST00000602557.1_Silent_p.I1036I|CSMD1_ENST00000542608.1_Silent_p.I1035I|CSMD1_ENST00000539096.1_Silent_p.I1035I|CSMD1_ENST00000537824.1_Silent_p.I1035I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1036	CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTGAAAATGTGATATTGAAGC	0.453000													6	16					0	0	0.217242	0	0
HYDIN	54768	broad.mit.edu	37	16	70934923	70934923	+	Missense_Mutation	SNP	T	T	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr16:70934923T>A	ENST00000393567.2	-	53	9182	c.9032A>T	c.(9031-9033)aAg>aTg	p.K3011M		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3011										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CCGAATAGCCTTCTTGATGTT	0.517000													35	118					0	0	0.139131	0	0
FGF10	2255	broad.mit.edu	37	5	44388667	44388667	+	Missense_Mutation	SNP	G	G	T	rs146669375		TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr5:44388667G>T	ENST00000264664.4	-	1	232	c.118C>A	c.(118-120)Ctt>Att	p.L40I		NM_004465.1	NP_004456.1	O15520	FGF10_HUMAN	fibroblast growth factor 10	40					actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			haematopoietic_and_lymphoid_tissue(1)|lung(11)|skin(1)	13	Lung NSC(6;1.12e-06)					TCCTGACCAAGGGCTTGGCAG	0.582000													19	44					2.89027e-11	3.18823e-11	0.069288	1	0
TMEM39A	55254	broad.mit.edu	37	3	119155755	119155755	+	Missense_Mutation	SNP	A	A	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr3:119155755A>C	ENST00000319172.5	-	7	1415	c.995T>G	c.(994-996)aTg>aGg	p.M332R		NM_018266.1	NP_060736.1	Q9NV64	TM39A_HUMAN	transmembrane protein 39A	332						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	13				GBM - Glioblastoma multiforme(114;0.244)		CGTGGTGAGCATGACAAAAGC	0.468000													114	237					0	0	0.139131	0	0
CD163L1	283316	broad.mit.edu	37	12	7510009	7510009	+	Silent	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr12:7510009G>A	ENST00000313599.3	-	19	4410	c.4353C>T	c.(4351-4353)gcC>gcT	p.A1451A	CD163L1_ENST00000396630.1_Silent_p.A1419A|CD163L1_ENST00000416109.2_Silent_p.A1461A			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1451						extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						GTCATTTTGTGGCTTCAGAGG	0.418000													17	45					0	0	0.219247	0	0
RARS	5917	broad.mit.edu	37	5	167922351	167922351	+	Missense_Mutation	SNP	C	C	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr5:167922351C>G	ENST00000231572.3	+	6	665	c.611C>G	c.(610-612)gCt>gGt	p.A204G	RARS_ENST00000538719.1_5'UTR	NM_002887.3	NP_002878.2	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	204					arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|stomach(1)	22	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		CCTAATATAGCTAAAGAGATG	0.418000													95	286					0	0	0.139131	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455579	5455579	+	Missense_Mutation	SNP	A	A	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr19:5455579A>G	ENST00000222033.4	+	1	154	c.77A>G	c.(76-78)cAc>cGc	p.H26R		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	26						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CCTCTGAGCCACGCGGTCATT	0.662000													12	49					0	0	0.105934	0	0
GAS2	2620	broad.mit.edu	37	11	22770733	22770733	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr11:22770733G>A	ENST00000454584.2	+	6	846	c.541G>A	c.(541-543)Gcc>Acc	p.A181T	GAS2_ENST00000433790.1_Missense_Mutation_p.A181T|GAS2_ENST00000278187.3_Missense_Mutation_p.A181T	NM_001143830.1	NP_001137302.1	O43903	GAS2_HUMAN	growth arrest-specific 2	181					cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(4)|stomach(1)	24						AACACTTTCTGCCCCTTCTCC	0.393000													9	72					0	0	0.047766	0	0
SRRT	51593	broad.mit.edu	37	7	100485480	100485480	+	Splice_Site	SNP	A	A	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr7:100485480A>G	ENST00000388793.4	+	17	2543	c.2323_splice	c.e17+1	p.I775_splice	SRRT_ENST00000432932.1_Splice_Site_p.S775_splice|SRRT_ENST00000457580.2_Splice_Site_p.S776_splice|SRRT_ENST00000347433.4_Splice_Site_p.I776_splice	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	776	Pro-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CCCCGCCCAGAGTAAGATACG	0.532000													18	77					0	0	0.069288	0	0
TRAF6	7189	broad.mit.edu	37	11	36511852	36511852	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr11:36511852C>T	ENST00000526995.1	-	7	1351	c.1105G>A	c.(1105-1107)Gag>Aag	p.E369K	TRAF6_ENST00000348124.5_Missense_Mutation_p.E369K	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	369	MATH.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				GGTTTCTCCTCTTCTTGACAT	0.453000													23	95					0	0	0.076483	0	0
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	A	G	rs60608267	by1000genomes	TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr12:132547093A>G	ENST00000333577.4	+	48	8398	c.8289A>G	c.(8287-8289)caA>caG	p.Q2763Q	EP400_ENST00000389561.2_Silent_p.Q2727Q|EP400_ENST00000330386.6_Silent_p.Q2646Q|EP400_ENST00000332482.4_Silent_p.Q2690Q|EP400_ENST00000389562.2_Silent_p.Q2726Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.567000													4	40					0	0	0.150653	0	0
TSTD2	158427	broad.mit.edu	37	9	100367110	100367110	+	Missense_Mutation	SNP	A	A	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr9:100367110A>T	ENST00000341170.4	-	9	1533	c.1151T>A	c.(1150-1152)aTc>aAc	p.I384N	TSTD2_ENST00000375172.2_Missense_Mutation_p.I158N|TSTD2_ENST00000375165.1_Missense_Mutation_p.I124N|TSTD2_ENST00000354801.2_Missense_Mutation_p.I124N	NM_139246.4	NP_640339.4	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like domain containing 2	384	Rhodanese.									large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	15						GTACTTGTGGATGCCACCCTT	0.473000													17	49					0	0	0.189662	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389562.2_Silent_p.Q2724Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													5	43					0	0	0.184627	0	0
GPT	2875	broad.mit.edu	37	8	145730220	145730220	+	Missense_Mutation	SNP	A	A	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr8:145730220A>G	ENST00000394955.2	+	3	542	c.319A>G	c.(319-321)Agg>Ggg	p.R107G	GPT_ENST00000528431.1_Missense_Mutation_p.R107G	NM_005309.2	NP_005300.1	P24298	ALAT1_HUMAN	glutamic-pyruvate transaminase (alanine aminotransferase)	107					gluconeogenesis	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)		L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TGCCAAGAAAAGGGCGGAGCG	0.632000													68	196					0	0	0.139131	0	0
CUX1	1523	broad.mit.edu	37	7	101754986	101754986	+	Missense_Mutation	SNP	A	A	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr7:101754986A>C	ENST00000360264.3	+	7	592	c.572A>C	c.(571-573)cAg>cCg	p.Q191P	CUX1_ENST00000550008.2_Missense_Mutation_p.Q180P|CUX1_ENST00000547394.2_Missense_Mutation_p.Q175P|CUX1_ENST00000437600.4_Missense_Mutation_p.Q191P|CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000292535.7_Missense_Mutation_p.Q180P|CUX1_ENST00000292538.4_Missense_Mutation_p.Q191P|CUX1_ENST00000549414.2_Missense_Mutation_p.Q180P|CUX1_ENST00000546411.2_Missense_Mutation_p.Q180P|CUX1_ENST00000425244.2_Missense_Mutation_p.Q145P|CUX1_ENST00000393824.3_Missense_Mutation_p.Q154P|CUX1_ENST00000556210.1_Missense_Mutation_p.Q180P	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	180					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						AGAAAGCTGCAGGAGACACAG	0.507000													10	40					0	0	0.058154	0	0
IGKV1D-42	28892	broad.mit.edu	37	2	90229367	90229367	+	RNA	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr2:90229367G>A	ENST00000390278.2	+	0	207																											GCAGAAACCAGGGAAATCCCC	0.493000													6	88					0	0	0.217242	0	0
ITGA7	3679	broad.mit.edu	37	12	56101360	56101360	+	Missense_Mutation	SNP	A	A	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr12:56101360A>G	ENST00000257880.7	-	1	326	c.107T>C	c.(106-108)cTg>cCg	p.L36P	ITGA7_ENST00000555728.1_Missense_Mutation_p.L36P|ITGA7_ENST00000452168.2_Intron|ITGA7_ENST00000394229.2_Missense_Mutation_p.L36P|ITGA7_ENST00000394230.2_Missense_Mutation_p.L36P|ITGA7_ENST00000347027.6_Missense_Mutation_p.L36P|ITGA7_ENST00000257879.6_Missense_Mutation_p.L36P|ITGA7_ENST00000553804.1_Missense_Mutation_p.L36P			Q13683	ITA7_HUMAN	integrin, alpha 7	36					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CATCACGTCCAGATTGAAGGC	0.662000													5	20					0	0	0.029380	0	0
RAPSN	5913	broad.mit.edu	37	11	47463274	47463274	+	Silent	SNP	G	G	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr11:47463274G>T	ENST00000298854.2	-	5	1014	c.801C>A	c.(799-801)ccC>ccA	p.P267P	RAPSN_ENST00000528356.1_5'UTR|RAPSN_ENST00000529341.1_Intron|RAPSN_ENST00000352508.3_Intron|RAPSN_ENST00000524487.1_Silent_p.P214P	NM_005055.4	NP_005046.2	Q13702	RAPSN_HUMAN	receptor-associated protein of the synapse	267					synaptic transmission, cholinergic	cell junction|cytoskeleton|postsynaptic membrane	acetylcholine receptor binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(6)|ovary(2)	12						AGTCGTACCTGGGGAAGGCTG	0.667000													3	27					0.115264	0.120914	0.115264	1	0
FAM129B	64855	broad.mit.edu	37	9	130287400	130287400	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr9:130287400C>T	ENST00000373312.3	-	4	571	c.358G>A	c.(358-360)Gca>Aca	p.A120T	FAM129B_ENST00000468379.1_5'UTR|FAM129B_ENST00000373314.3_Missense_Mutation_p.A107T	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	120	PH.						protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						TTGTAGCCTGCACTGTTGATG	0.587000													4	58					0	0	0.184627	0	0
RPL21	6144	broad.mit.edu	37	13	27828378	27828378	+	Missense_Mutation	SNP	A	A	T			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr13:27828378A>T	ENST00000311549.6	+	3	378	c.89A>T	c.(88-90)tAt>tTt	p.Y30F	RPL21_ENST00000326092.4_Missense_Mutation_p.Y30F|RPL21_ENST00000319826.4_Missense_Mutation_p.Y30F|RPL21_ENST00000272274.4_Missense_Mutation_p.Y30F	NM_000982.3	NP_000973.2	P46778	RL21_HUMAN	ribosomal protein L21	30					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			large_intestine(1)|lung(1)	2		Lung SC(185;0.0156)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0287)|OV - Ovarian serous cystadenocarcinoma(117;0.118)|Epithelial(112;0.139)|GBM - Glioblastoma multiforme(144;0.21)		TTGGCCACATATATGCGAATC	0.289000													12	81					0	0	0.093190	0	0
IQGAP3	128239	broad.mit.edu	37	1	156521627	156521627	+	Missense_Mutation	SNP	A	A	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr1:156521627A>G	ENST00000361170.2	-	15	1614	c.1604T>C	c.(1603-1605)cTg>cCg	p.L535P		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	535					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCCTTTGTCCAGAGCCTCATT	0.572000													25	61					0	0	0.099896	0	0
WDR96	80217	broad.mit.edu	37	10	105990520	105990520	+	Missense_Mutation	SNP	T	T	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr10:105990520T>C	ENST00000357060.3	-	2	262	c.147A>G	c.(145-147)atA>atG	p.I49M	WDR96_ENST00000278064.2_De_novo_Start_InFrame|WDR96_ENST00000428666.1_Missense_Mutation_p.I49M|WDR96_ENST00000369719.1_De_novo_Start_InFrame|WDR96_ENST00000369720.1_De_novo_Start_InFrame	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	49										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TATTAATAAATATTACATAAT	0.388000													24	59					0	0	0.069288	0	0
UBE2O	63893	broad.mit.edu	37	17	74392603	74392603	+	Silent	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr17:74392603G>A	ENST00000319380.7	-	14	2479	c.2415C>T	c.(2413-2415)gaC>gaT	p.D805D		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	805							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						TGGGTGGCCCGTCCTTGCCAG	0.632000													8	262					0	0	0.047766	0	0
EXOC1	55763	broad.mit.edu	37	4	56768547	56768547	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr4:56768547G>A	ENST00000381295.2	+	18	2723	c.2375G>A	c.(2374-2376)gGc>gAc	p.G792D	EXOC1_ENST00000346134.7_Missense_Mutation_p.G792D|EXOC1_ENST00000349598.6_Missense_Mutation_p.G777D	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1	792					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					GTGGCACAGGGCATAAGGGAG	0.363000													3	60					0	0	0.150653	0	0
MGAT4A	11320	broad.mit.edu	37	2	99294822	99294822	+	Missense_Mutation	SNP	G	G	C			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr2:99294822G>C	ENST00000393487.1	-	3	520	c.207C>G	c.(205-207)ttC>ttG	p.F69L	MGAT4A_ENST00000409391.1_Missense_Mutation_p.F69L|MGAT4A_ENST00000264968.2_Missense_Mutation_p.F69L	NM_012214.2	NP_036346.1	Q9UM21	MGT4A_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	69					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	19						CTACACGCTTGAACTGTTGCA	0.333000													41	113					0	0	0.139131	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	40					0	0	0.150653	0	0
GCK	2645	broad.mit.edu	37	7	44191996	44191996	+	Silent	SNP	C	C	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr7:44191996C>G	ENST00000403799.3	-	3	706	c.237G>C	c.(235-237)ctG>ctC	p.L79L	GCK_ENST00000395796.3_Silent_p.L78L|GCK_ENST00000345378.2_Silent_p.L80L|GCK_ENST00000437084.1_Silent_p.L79L	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	79					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						TAGTGCCACCCAGGTCCAGGG	0.607000													25	92					0	0	0.076483	0	0
CELSR1	9620	broad.mit.edu	37	22	46806460	46806460	+	Splice_Site	SNP	T	T	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr22:46806460T>G	ENST00000262738.3	-	7	4769		c.e7-2			NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1						central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCCAGGGACCTGGGTAGGTAA	0.632000													24	51					0	0	0.076483	0	0
ZNF219	51222	broad.mit.edu	37	14	21559281	21559281	+	Missense_Mutation	SNP	C	C	G			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr14:21559281C>G	ENST00000360947.3	-	5	1994	c.1583G>C	c.(1582-1584)tGt>tCt	p.C528S	ZNF219_ENST00000451119.2_Missense_Mutation_p.C528S|RP11-998D10.7_ENST00000554733.2_lincRNA|ZNF219_ENST00000421093.2_Missense_Mutation_p.C528S	NM_016423.2	NP_057507.2	Q9P2Y4	ZN219_HUMAN	zinc finger protein 219	528					negative regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|histamine receptor activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(2)	8	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;9.86e-11)|Epithelial(56;1.27e-08)|all cancers(55;6.06e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GCAGTGCGGACACTTGTAGGG	0.672000													3	1					0	0	0.115264	0	0
SEC22B	9554	broad.mit.edu	37	1	145116147	145116148	+	RNA	INS	-	-	A	rs138980379		TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr1:145116147_145116148insA	ENST00000453618.1	+	0	1233_1234							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										AGTAGATTGTTATTTCGTTTTT	0.416													2	4	---	---	---	---					
LIMS2	55679	broad.mit.edu	37	2	128398541	128398547	+	Frame_Shift_Del	DEL	TCACACT	TCACACT	-			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr2:128398541_128398547delTCACACT	ENST00000409455.1	-	7	1297_1303	c.662_668delAGTGTGA	c.(661-669)agfs	p.KCE221fs	LIMS2_ENST00000409254.1_Frame_Shift_Del_p.KCE74fs|LIMS2_ENST00000324938.5_Frame_Shift_Del_p.KCE250fs|LIMS2_ENST00000410038.1_Frame_Shift_Del_p.KCE74fs|LIMS2_ENST00000355119.4_Frame_Shift_Del_p.KCE226fs|LIMS2_ENST00000409754.1_Frame_Shift_Del_p.KCE74fs|LIMS2_ENST00000409808.2_Frame_Shift_Del_p.KCE221fs|LIMS2_ENST00000545738.2_Frame_Shift_Del_p.KCE248fs|LIMS2_ENST00000409286.1_Frame_Shift_Del_p.KCE74fs|LIMS2_ENST00000410011.1_Frame_Shift_Del_p.KCE221fs			Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	226	LIM zinc-binding 4.				cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		GAATGGCTTCTCACACTTGGCACAGAC	0.614													24	91	---	---	---	---					
BAP1	8314	broad.mit.edu	37	3	52436403	52436403	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr3:52436403delG	ENST00000460680.1	-	17	2562	c.2091delC	c.(2089-2091)tcfs	p.S697fs	BAP1_ENST00000296288.5_Frame_Shift_Del_p.S679fs	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	697	Interaction with BRCA1.				monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.Q694fs*14(1)		NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		GCCGCCGCACGGAGATGTTCT	0.652			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							4	4	---	---	---	---					
MCM9	254394	broad.mit.edu	37	6	119252784	119252784	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr6:119252784delA	ENST00000316316.6	-	2	391	c.105delT	c.(103-105)gafs	p.D35fs	MCM9_ENST00000316068.3_Frame_Shift_Del_p.D35fs	NM_017696.2	NP_060166.2	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	35					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		GGTAATGAGCATCTTCATCCC	0.388													16	114	---	---	---	---					
AQP1	358	broad.mit.edu	37	7	30951547	30951552	+	In_Frame_Del	DEL	AGCTCT	AGCTCT	-			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr7:30951547_30951552delAGCTCT	ENST00000311813.4	+	1	78_83	c.23_28delAGCTCT	c.(22-30)atc>a	p.KLF8del	AQP1_ENST00000434909.2_Intron|AQP1_ENST00000509504.1_Intron	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				TTCAAGAAGAAGCTCTTCTGGAGGGC	0.617													16	71	---	---	---	---					
GRM5	2915	broad.mit.edu	37	11	88242235	88242235	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr11:88242235delC	ENST00000418177.2	-	10	3531	c.3164delG	c.(3163-3165)gcfs	p.G1055fs	GRM5_ENST00000455756.2_Frame_Shift_Del_p.G1023fs|GRM5_ENST00000305432.5_Frame_Shift_Del_p.G1023fs|GRM5_ENST00000393297.1_Intron|GRM5-AS1_ENST00000526448.1_RNA|GRM5_ENST00000305447.4_Frame_Shift_Del_p.G1055fs			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	1055					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CATGAGGGAGCCCTGCGAGGA	0.692													2	4	---	---	---	---					
CLEC17A	388512	broad.mit.edu	37	19	14698466	14698467	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr19:14698466_14698467insTT	ENST00000547437.1	+	3	239_240	c.162_163insTT	c.(160-165)aacaacfs	p.N55fs	CLEC17A_ENST00000417570.1_Frame_Shift_Ins_p.N55fs|CLEC17A_ENST00000397439.2_Frame_Shift_Ins_p.N55fs	NM_207390.3	NP_997273.3	Q6ZS10	CL17A_HUMAN	C-type lectin domain family 17, member A	55						cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity										ACTATGAGAACTCAACACCTCC	0.569													7	21	---	---	---	---					
PRR12	57479	broad.mit.edu	37	19	50118194	50118194	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr19:50118194delA	ENST00000418929.2	+	8	4964	c.4952delA	c.(4951-4953)gafs	p.E1651fs		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	830							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		AAGTTCCTGGAAAATGTCAAT	0.512													28	79	---	---	---	---					
SYNJ1	8867	broad.mit.edu	37	21	34012084	34012084	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chr21:34012084delA	ENST00000382499.2	-	30	3710	c.3711delT	c.(3709-3711)atfs	p.I1237fs	SYNJ1_ENST00000433931.2_Frame_Shift_Del_p.I1237fs|SYNJ1_ENST00000382491.3_Frame_Shift_Del_p.I1151fs|SYNJ1_ENST00000357345.3_Frame_Shift_Del_p.I1182fs|SYNJ1_ENST00000322229.7_Frame_Shift_Del_p.I1198fs	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	1198	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						CACGAGGAGGAATCGTCTACA	0.443													18	47	---	---	---	---					
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-B4-5838-01A-11D-1669-08	TCGA-B4-5838-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14e44673-c942-45f2-a588-cae1d3655bb8	72b65a50-86e6-47ba-84a9-83c4c33496be	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			3	4	---	---	---	---					
