Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BBOX1	8424	broad.mit.edu	37	11	27077073	27077073	+	Silent	SNP	A	A	G			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr11:27077073A>G	ENST00000263182.3	+	3	464	c.96A>G	c.(94-96)gtA>gtG	p.V32V	BBOX1_ENST00000527505.1_3'UTR|BBOX1_ENST00000529202.1_Silent_p.V32V|BBOX1_ENST00000528583.1_Silent_p.V32V|BBOX1_ENST00000525090.1_Silent_p.V32V|RP11-1L12.3_ENST00000526061.1_RNA	NM_003986.2	NP_003977.1	O75936	BODG_HUMAN	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	32					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	23					Succinic acid(DB00139)|Vitamin C(DB00126)	ACCCAGCTGTATGGTTGAGAG	0.468000													7	43					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	13959903	13959903	+	Silent	SNP	C	C	T			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr8:13959903C>T	ENST00000382080.1	-	7	1441	c.726G>A	c.(724-726)ctG>ctA	p.L242L	SGCZ_ENST00000421524.2_Silent_p.L195L	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	229					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CTGTAGATTGCAGATGGAGCT	0.507000													3	47					0	0	1	0	0
FOXK2	3607	broad.mit.edu	37	17	80541951	80541951	+	Missense_Mutation	SNP	C	C	G			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr17:80541951C>G	ENST00000335255.5	+	6	1340	c.1166C>G	c.(1165-1167)aCc>aGc	p.T389S		NM_004514.3	NP_004505.2	Q01167	FOXK2_HUMAN	forkhead box K2	389					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	17	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			GGCGCCCAGACCCCTGAGAGC	0.632000													3	29					0	0	1	0	0
CALML6	163688	broad.mit.edu	37	1	1848242	1848242	+	Missense_Mutation	SNP	A	A	T			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr1:1848242A>T	ENST00000307786.3	+	4	759	c.305A>T	c.(304-306)cAt>cTt	p.H102L	CALML6_ENST00000462293.1_3'UTR	NM_138705.2	NP_619650.2	Q8TD86	CALL6_HUMAN	calmodulin-like 6	102	EF-hand 2.					cytoplasm|nucleus	calcium ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(1)|prostate(2)	7	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.94e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.83e-23)|GBM - Glioblastoma multiforme(42;3.23e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GGAGTTTACCATGAGAAGGCC	0.562000													9	107					0	0	1	0	0
GLUD1P2	0	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													3	21					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	85906101	85906101	+	Missense_Mutation	SNP	A	A	G			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chrX:85906101A>G	ENST00000373131.1	+	3	827	c.664A>G	c.(664-666)Aac>Gac	p.N222D	DACH2_ENST00000510272.1_Missense_Mutation_p.N16D|DACH2_ENST00000373125.4_Missense_Mutation_p.N235D|DACH2_ENST00000508860.1_Missense_Mutation_p.N68D	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	235					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						TATGGCTATGAACACTCTTCA	0.408000													9	16					0	0	1	0	0
ZBTB9	221504	broad.mit.edu	37	6	33423522	33423522	+	Silent	SNP	G	G	A			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr6:33423522G>A	ENST00000395064.2	+	2	913	c.645G>A	c.(643-645)gaG>gaA	p.E215E		NM_152735.3	NP_689948.1	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	215					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(1)|upper_aerodigestive_tract(2)	11						aagaagaagaggaggaggagg	0.552000													3	57					0	0	1	0	0
ACOT9	23597	broad.mit.edu	37	X	23723894	23723894	+	Silent	SNP	G	G	A			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chrX:23723894G>A	ENST00000379303.5	-	12	1052	c.924C>T	c.(922-924)tgC>tgT	p.C308C	ACOT9_ENST00000336430.7_Silent_p.C299C|ACOT9_ENST00000379295.1_Silent_p.C239C	NM_001037171.1	NP_001032248.1	Q9Y305	ACOT9_HUMAN	acyl-CoA thioesterase 9	299					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			breast(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(4)|pancreas(1)|skin(1)	15						CCTGAGGGTGGCAAATTTCCA	0.373000													5	236					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21176193	21176193	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr12:21176193G>A	ENST00000381541.3	+	6	764	c.699G>A	c.(697-699)atG>atA	p.M233I	SLCO1B7_ENST00000554957.1_Missense_Mutation_p.M233I|SLCO1B3_ENST00000553473.1_Intron|LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.M186I																							TTGCTAAAATGTATGTGGATA	0.373000													3	18					0	0	1	0	0
AMER1	139285	broad.mit.edu	37	X	63411230	63411230	+	Missense_Mutation	SNP	C	C	T	rs147754688	byFrequency	TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chrX:63411230C>T	ENST00000330258.3	-	2	2209	c.1937G>A	c.(1936-1938)cGg>cAg	p.R646Q	AMER1_ENST00000403336.1_Missense_Mutation_p.R646Q|AMER1_ENST00000374869.3_Missense_Mutation_p.R646Q	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									CTTCTCCTGCCGGGCCTGGGT	0.612000													13	23					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18845963	18845963	+	RNA	SNP	C	C	T	rs144351257	by1000genomes	TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr22:18845963C>T	ENST00000412938.1	+	0	3321																											GATCTCATCGCGGACACCACT	0.517000													4	35					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								14	31					0	0	1	0	0
MLLT6	4302	broad.mit.edu	37	17	36871961	36871961	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr17:36871961C>T	ENST00000325718.7	+	9	1007	c.916C>T	c.(916-918)Cat>Tat	p.H306Y	CTB-58E17.9_ENST00000579499.1_RNA	NM_005937.3	NP_005928.2	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	306					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(7;4.43e-21)					GTCTTCCAGCCATAGCCTGAG	0.562000			T	MLL	AL								10	23					0	0	1	0	0
RIN2	54453	broad.mit.edu	37	20	19955639	19955639	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr20:19955639C>T	ENST00000255006.6	+	8	1266	c.1117C>T	c.(1117-1119)Cgg>Tgg	p.R373W	RIN2_ENST00000484638.1_3'UTR|RIN2_ENST00000440354.2_Intron	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	324					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						CACAAGCCCTCGGCTGGCCAG	0.602000													6	41					0	0	1	0	0
GAB2	9846	broad.mit.edu	37	11	77937662	77937662	+	Silent	SNP	T	T	G			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr11:77937662T>G	ENST00000361507.4	-	4	1141	c.1056A>C	c.(1054-1056)ccA>ccC	p.P352P	GAB2_ENST00000340149.2_Silent_p.P314P	NM_080491.2	NP_536739.1	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2	352					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity		INTS4/GAB2(2)	NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			GGGGGCGGGGTGGGGGAGCTA	0.582000													6	53					0	0	1	0	0
EHD1	10938	broad.mit.edu	37	11	64622163	64622163	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr11:64622163C>T	ENST00000320631.3	-	5	1501	c.1247G>A	c.(1246-1248)gGc>gAc	p.G416D	EHD1_ENST00000488711.1_5'UTR|EHD1_ENST00000359393.2_Missense_Mutation_p.G416D	NM_006795.2	NP_006786.2	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	416					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						GTTCATGGTGCCGTCAAAGGC	0.672000													7	171					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142185447	142185447	+	Silent	SNP	C	C	T			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr8:142185447C>T	ENST00000519811.1	+	14	2494	c.2424C>T	c.(2422-2424)tcC>tcT	p.S808S	DENND3_ENST00000262585.2_Silent_p.S728S|DENND3_ENST00000424248.1_Silent_p.S676S			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	728										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			TGTCCAGCTCCGTCAAGACAA	0.547000											OREG0019025	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	38					0	0	1	0	0
TRIM27	5987	broad.mit.edu	37	6	28887928	28887928	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr6:28887928C>T	ENST00000377199.3	-	3	964	c.608G>A	c.(607-609)cGc>cAc	p.R203H	TRIM27_ENST00000498117.1_5'UTR|TRIM27_ENST00000377194.3_Missense_Mutation_p.R203H	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	203					cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						CTCCTCAAGGCGGGCCAGGAG	0.517000			T	RET	papillary thyroid								18	115					0	0	1	0	0
MLTK	0	broad.mit.edu	37	2	174131122	174131122	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr2:174131122C>T	ENST00000375213.3	+	20	2125	c.2047C>T	c.(2047-2049)Cgt>Tgt	p.R683C	MLK7-AS1_ENST00000423106.2_RNA|MLTK_ENST00000409176.2_Missense_Mutation_p.R683C|MLK7-AS1_ENST00000422703.1_RNA	NM_016653.2	NP_057737.2																					CAAATATGGACGTGGTAGTAT	0.458000													23	41					0	0	1	0	0
SLK	9748	broad.mit.edu	37	10	105762041	105762041	+	Missense_Mutation	SNP	C	C	T	rs140715399		TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr10:105762041C>T	ENST00000369755.3	+	9	1650	c.1105C>T	c.(1105-1107)Cgt>Tgt	p.R369C	SLK_ENST00000335753.4_Missense_Mutation_p.R369C	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	369	Glu-rich.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AAAAACAGAACGTAGTAACTC	0.368000													14	134					0	0	1	0	0
TRMT2A	27037	broad.mit.edu	37	22	20104015	20104015	+	Missense_Mutation	SNP	C	C	A			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr22:20104015C>A	ENST00000252136.7	-	2	533	c.145G>T	c.(145-147)Gcg>Tcg	p.A49S	RANBP1_ENST00000430524.1_Intron|TRMT2A_ENST00000403707.3_Missense_Mutation_p.A49S|TRMT2A_ENST00000439169.2_Missense_Mutation_p.A49S|TRMT2A_ENST00000404751.3_Missense_Mutation_p.A49S	NM_001257994.1|NM_022727.5|NM_182984.4	NP_001244923.1|NP_073564.3|NP_892029.2	Q8IZ69	TRM2A_HUMAN	tRNA methyltransferase 2 homolog A (S. cerevisiae)	49					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(2)|endometrium(2)|lung(5)	9						CCTGTAGCCGCCCCAGCGCCC	0.647000													3	44					0.115264	0.115264	1	1	0
SLC30A8	169026	broad.mit.edu	37	8	118183316	118183316	+	Silent	SNP	T	T	A			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr8:118183316T>A	ENST00000427715.2	+	10	1160	c.726T>A	c.(724-726)atT>atA	p.I242I	SLC30A8_ENST00000519688.1_Silent_p.I242I|SLC30A8_ENST00000456015.2_Silent_p.I291I|SLC30A8_ENST00000521243.1_Silent_p.I242I	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	291					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			AAGAGCTTATTTTAGCAGTCG	0.453000													9	92					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53576145	53576145	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chrX:53576145G>T	ENST00000342160.3	-	66	10267	c.9810C>A	c.(9808-9810)gaC>gaA	p.D3270E	HUWE1_ENST00000262854.6_Missense_Mutation_p.D3270E			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3270					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TGTGTAGCAGGTCCAGGGGAC	0.493000													29	138					3.65163e-15	4.01679e-15	1	1	0
SHANK2	22941	broad.mit.edu	37	11	70507799	70507799	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr11:70507799C>T	ENST00000449833.2	-	1	124	c.74G>A	c.(73-75)cGg>cAg	p.R25Q	SHANK2_ENST00000449116.2_Missense_Mutation_p.R25Q|SHANK2_ENST00000409161.1_Missense_Mutation_p.R24Q|SHANK2_ENST00000409530.1_Missense_Mutation_p.R24Q|SHANK2_ENST00000357171.3_Missense_Mutation_p.R25Q|SHANK2_ENST00000338508.4_Intron|SHANK2_ENST00000423696.2_Intron	NM_133266.3	NP_573573.2	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	0					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GAGAGAATTCCGGGGACAGCG	0.542000													4	177					0	0	1	0	0
BTN2A3P	0	broad.mit.edu	37	6	26428451	26428451	+	RNA	DEL	A	A	-	rs139821417		TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr6:26428451delA	ENST00000466808.2	+	0	1304																											gtgtctaattaaaaaaaaaaa	0.448													2	4	---	---	---	---					
RP11-981G7.2	0	broad.mit.edu	37	8	10335889	10335903	+	RNA	DEL	GGCTGCAGTGGTTGT	GGCTGCAGTGGTTGT	-	rs55641852		TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr8:10335889_10335903delGGCTGCAGTGGTTGT	ENST00000517732.1	+	0	223				RP11-981G7.3_ENST00000520494.1_lincRNA																							GTGGTTGTCAGGCTGCAGTGGTTGTGGCTGCAGTG	0.586													4	6	---	---	---	---					
RP11-178C3.2	0	broad.mit.edu	37	17	58066608	58066608	+	RNA	DEL	T	T	-			TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr17:58066608delT	ENST00000586209.1	+	0	158																											TTGATTGTGATTTTTTTTTTT	0.313													2	4	---	---	---	---					
AC008103.5	0	broad.mit.edu	37	22	18842473	18842473	+	RNA	DEL	G	G	-	rs66618606		TCGA-P5-A781-01A-11D-A32B-08	TCGA-P5-A781-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31b4159e-4e59-46bc-a18f-5f2790e533bf	b6938bbf-14a5-4137-952c-1874ee5e3c1c	g.chr22:18842473delG	ENST00000412938.1	+	0	2208																											AGCTGCTGGTGGGGAGGTCTT	0.647													4	4	---	---	---	---					
