Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRDM9	56979	broad.mit.edu	37	5	23522839	23522839	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr5:23522839C>T	ENST00000296682.3	+	8	909	c.727C>T	c.(727-729)Ccc>Tcc	p.P243S		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	243					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CCTCAGTCTGCCCCCAGGGCT	0.577000										HNSCC(3;0.000094)			29	58					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38622756	38622756	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr3:38622756C>A	ENST00000413689.1	-	17	3087	c.2894G>T	c.(2893-2895)cGc>cTc	p.R965L	SCN5A_ENST00000425664.1_Missense_Mutation_p.R965L|SCN5A_ENST00000451551.2_Missense_Mutation_p.R965L|SCN5A_ENST00000443581.1_Missense_Mutation_p.R965L|SCN5A_ENST00000450102.2_Missense_Mutation_p.R965L|SCN5A_ENST00000414099.2_Missense_Mutation_p.R965L|SCN5A_ENST00000423572.2_Missense_Mutation_p.R965L|SCN5A_ENST00000455624.2_Missense_Mutation_p.R965L|SCN5A_ENST00000333535.4_Missense_Mutation_p.R965L|SCN5A_ENST00000449557.2_Missense_Mutation_p.R965L	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	965			R -> C (in BRS1; steady state inactivation shifted to a more negative potential; slower recovery from inactivation).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity	p.R965H(2)		NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CCTCTGGATGCGGGCCAGGGC	0.627000													4	47					1	1	1	1	0
PCDH19	57526	broad.mit.edu	37	X	99662844	99662844	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chrX:99662844G>A	ENST00000373034.4	-	1	2427	c.752C>T	c.(751-753)tCg>tTg	p.S251L	PCDH19_ENST00000255531.7_Missense_Mutation_p.S251L|PCDH19_ENST00000420881.2_Missense_Mutation_p.S251L	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	251	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						GTTGGGAGGCGAGTTTTCTGG	0.602000													74	209					0	0	1	0	0
MS4A1	931	broad.mit.edu	37	11	60233595	60233595	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr11:60233595A>C	ENST00000534668.1	+	5	827	c.538A>C	c.(538-540)Acc>Ccc	p.T180P	MS4A1_ENST00000345732.4_Missense_Mutation_p.T180P|MS4A1_ENST00000528313.1_Intron|MS4A1_ENST00000389939.2_Missense_Mutation_p.T180P|MS4A1_ENST00000532073.1_Missense_Mutation_p.T180P	NM_152866.2	NP_690605.1	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member 1	180					B cell activation|immune response	integral to plasma membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	CTCCCCATCTACCCAATACTG	0.373000													16	224					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105361169	105361169	+	Silent	SNP	A	A	C			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr14:105361169A>C	ENST00000453495.1	+	19	4875	c.4647A>C	c.(4645-4647)tcA>tcC	p.S1549S	CEP170B_ENST00000556508.1_Silent_p.S1478S|CEP170B_ENST00000418279.1_Silent_p.S1443S|CEP170B_ENST00000414716.3_Silent_p.S1513S					centrosomal protein 170B									p.S1513S(3)|p.S1479S(3)|p.S1478S(1)									GCCCACCCTCACCCGCCTCAG	0.711000													9	24					0	0	1	0	0
USP48	84196	broad.mit.edu	37	1	22030798	22030798	+	Silent	SNP	C	C	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr1:22030798C>T	ENST00000308271.9	-	20	3120	c.2472G>A	c.(2470-2472)gtG>gtA	p.V824V	USP48_ENST00000400301.1_Silent_p.V824V|USP48_ENST00000374732.3_Silent_p.V362V|USP48_ENST00000529637.1_Silent_p.V836V	NM_032236.5	NP_115612.4	Q86UV5	UBP48_HUMAN	ubiquitin specific peptidase 48	824	DUSP 3.				ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(14)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		TTACATCTCCCACTTCAATTC	0.358000													69	112					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28919761	28919761	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr18:28919761G>A	ENST00000257192.4	+	11	1672	c.1460G>A	c.(1459-1461)gGt>gAt	p.G487D		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	487	Cadherin 4.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CAAAGTTTTGGTAATGACGAC	0.328000													8	138					0	0	1	0	0
UACA	55075	broad.mit.edu	37	15	70961406	70961406	+	Silent	SNP	G	G	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr15:70961406G>A	ENST00000322954.6	-	16	1802	c.1617C>T	c.(1615-1617)acC>acT	p.T539T	UACA_ENST00000560441.1_Silent_p.T524T|UACA_ENST00000379983.2_Silent_p.T526T|UACA_ENST00000539319.1_Silent_p.T430T	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	539						cytoskeleton|extracellular region		p.T526T(1)|p.T539T(1)		breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						TCAGTTCCTCGGTTAGTCTGT	0.383000													15	355					0	0	1	0	0
SLC22A6	9356	broad.mit.edu	37	11	62744652	62744652	+	Nonsense_Mutation	SNP	C	C	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr11:62744652C>T	ENST00000377871.3	-	9	1835	c.1569G>A	c.(1567-1569)tgG>tgA	p.W523*	SLC22A6_ENST00000458333.2_Intron|SLC22A6_ENST00000421062.2_Nonsense_Mutation_p.W479*|SLC22A6_ENST00000360421.4_Intron	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	523					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						gagTGGGGGCCCACCTGCTCT	0.607000													8	213					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74625122	74625122	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr15:74625122G>A	ENST00000321288.5	+	18	2483	c.2483G>A	c.(2482-2484)cGg>cAg	p.R828Q	CCDC33_ENST00000268082.4_Missense_Mutation_p.R218Q|CCDC33_ENST00000558821.1_Missense_Mutation_p.R218Q|CCDC33_ENST00000398814.3_Missense_Mutation_p.R625Q			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	828							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GCGAAGCTGCGGACGGAGCTG	0.602000													14	191					0	0	1	0	0
RP11-178C3.2	0	broad.mit.edu	37	17	58066651	58066651	+	RNA	SNP	C	C	T	rs144367363	by1000genomes	TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr17:58066651C>T	ENST00000586209.1	+	0	158																											ACTGGTAAAGCTGTTTAAGAG	0.333000													3	39					0	0	1	0	0
GPR141	353345	broad.mit.edu	37	7	37780775	37780775	+	Silent	SNP	C	C	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr7:37780775C>T	ENST00000447769.1	+	4	1069	c.780C>T	c.(778-780)agC>agT	p.S260S	GPR141_ENST00000334425.1_Silent_p.S260S|EPDR1_ENST00000476620.1_Intron|GPR141_ENST00000461610.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	260						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CCTGTAACAGCAAGGTTGCAT	0.383000													5	262					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	G	A	rs121913499		TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr2:209113113G>A	ENST00000415913.1	-	4	775	c.394C>T	c.(394-396)Cgt>Tgt	p.R132C	IDH1_ENST00000345146.2_Missense_Mutation_p.R132C|IDH1_ENST00000446179.1_Missense_Mutation_p.R132C			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132C(446)|p.R132G(125)|p.R132S(106)|p.G131_R132>VL(1)|p.R132V(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma								64	124					0	0	1	0	0
VAC14	55697	broad.mit.edu	37	16	70834803	70834803	+	Translation_Start_Site	SNP	T	T	C			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr16:70834803T>C	ENST00000261776.5	-	1	261	c.1A>G	c.(1-3)Atg>Gtg	p.M1V		NM_018052.3	NP_060522.3	Q08AM6	VAC14_HUMAN	Vac14 homolog (S. cerevisiae)	1					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(10)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Ovarian(137;0.0699)				TCGGGGTTCATGGTGGCAGCT	0.697000													4	83					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43512971	43512971	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr15:43512971G>A	ENST00000300215.3	-	1	510	c.53C>T	c.(52-54)gCa>gTa	p.A18V	EPB42_ENST00000441366.2_Intron|EPB42_ENST00000540029.1_Intron			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	0					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		TGCGGGGGCTGCATACAGTCC	0.582000													5	323					0	0	1	0	0
SEC23IP	11196	broad.mit.edu	37	10	121663645	121663645	+	Silent	SNP	C	C	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr10:121663645C>T	ENST00000369075.3	+	4	1029	c.957C>T	c.(955-957)taC>taT	p.Y319Y	SEC23IP_ENST00000543134.1_Silent_p.Y108Y	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	319	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		GAGGGCGCTACGATGTTTACC	0.488000													56	116					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77526572	77526572	+	Silent	SNP	A	A	G			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr3:77526572A>G	ENST00000461745.1	+	3	1296	c.396A>G	c.(394-396)cgA>cgG	p.R132R	ROBO2_ENST00000332191.8_Silent_p.R132R|ROBO2_ENST00000487694.3_Silent_p.R148R	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	132					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAGTGTTACGAGATGACTTCC	0.463000													20	275					0	0	1	0	0
ZXDB	158586	broad.mit.edu	37	X	57619097	57619097	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chrX:57619097G>A	ENST00000374888.1	+	1	829	c.616G>A	c.(616-618)Ggg>Agg	p.G206R		NM_007157.3	NP_009088.1	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding	p.G206R(2)		NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(2)|skin(6)	27						CCAGCAGCCCGGGTGTCTGAT	0.711000													3	32					0	0	1	0	0
CMA1	1215	broad.mit.edu	37	14	24974844	24974844	+	Silent	SNP	G	G	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr14:24974844G>A	ENST00000250378.3	-	5	651	c.622C>T	c.(622-624)Ctg>Ttg	p.L208L	CMA1_ENST00000206446.4_Silent_p.L97L|RP11-80A15.1_ENST00000555109.1_Intron	NM_001836.3	NP_001827.1	P23946	CMA1_HUMAN	chymase 1, mast cell	208	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|lung(8)|pancreas(1)|prostate(1)	11				GBM - Glioblastoma multiforme(265;0.0271)		CCAGCACACAGAAGAGGGCCC	0.612000													8	142					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131216554	131216554	+	Splice_Site	SNP	C	C	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chrX:131216554C>A	ENST00000298542.4	-	9	917	c.741_splice	c.e9-1	p.V248_splice	FRMD7_ENST00000464296.1_Splice_Site_p.V233_splice|FRMD7_ENST00000370879.1_Splice_Site_p.V128_splice	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	248	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					TTGCACAACACCTGTATAAAC	0.448000													11	297					4.68919e-08	5.12539e-08	1	1	0
OR4F6	390648	broad.mit.edu	37	15	102346232	102346232	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr15:102346232A>G	ENST00000328882.4	+	1	331	c.310A>G	c.(310-312)Atc>Gtc	p.I104V		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			GATCTTCTTTATCCATGCAGT	0.458000													13	465					0	0	1	0	0
SSTR1	0	broad.mit.edu	37	14	38679188	38679188	+	Silent	SNP	C	C	G			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr14:38679188C>G	ENST00000267377.2	+	3	1211	c.594C>G	c.(592-594)acC>acG	p.T198T		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	198					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	TCTCTCGCACCGCGGCCAACA	0.637000													7	98					0	0	1	0	0
C1orf95	375057	broad.mit.edu	37	1	226784542	226784542	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr1:226784542G>A	ENST00000366788.3	+	2	347	c.242G>A	c.(241-243)cGc>cAc	p.R81H	C1orf95_ENST00000366789.4_Missense_Mutation_p.R81H	NM_001003665.3	NP_001003665.1	Q69YW2	CA095_HUMAN	chromosome 1 open reading frame 95	81						integral to membrane				large_intestine(1)|lung(4)|ovary(3)	8	Breast(184;0.133)	Prostate(94;0.0885)		GBM - Glioblastoma multiforme(131;0.113)		TGCGGGGCCCGCACCGACCTC	0.617000													5	266					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128812	45128812	+	RNA	SNP	C	C	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr17:45128812C>T	ENST00000575173.1	-	0	418																											AGTCCTGTTTCTGTGTGGATT	0.373000													5	91					0	0	1	0	0
IGHV4OR15-8	0	broad.mit.edu	37	15	22473151	22473151	+	RNA	SNP	G	G	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr15:22473151G>T	ENST00000557788.2	-	0	119																											AGACAACGCAGGTGAGGGACA	0.612000													11	523					1.58986e-06	1.69826e-06	1	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33576786	33576786	+	Silent	SNP	C	C	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr5:33576786C>T	ENST00000504830.1	-	19	3680	c.3345G>A	c.(3343-3345)tcG>tcA	p.S1115S	ADAMTS12_ENST00000352040.3_Silent_p.S1030S	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1115	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GGCCTCCCTCCGAGGTAGGAC	0.493000										HNSCC(64;0.19)			4	176					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56815192	56815192	+	Silent	SNP	C	C	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr12:56815192C>T	ENST00000229201.4	-	23	2962	c.2808G>A	c.(2806-2808)gtG>gtA	p.V936V	TIMELESS_ENST00000554616.1_Silent_p.V434V|TIMELESS_ENST00000553532.1_Silent_p.V937V	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	937					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						GCCGCTCAGCCACCAGCCCCA	0.517000													14	247					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229773923	229773923	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr1:229773923C>T	ENST00000258243.2	+	4	3699	c.3563C>T	c.(3562-3564)gCc>gTc	p.A1188V		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	1188						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						TTCTTTTTGGCCCCAGAACTG	0.453000													5	306					0	0	1	0	0
ECM1	1893	broad.mit.edu	37	1	150483973	150483973	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr1:150483973C>T	ENST00000369047.4	+	7	874	c.749C>T	c.(748-750)tCg>tTg	p.S250L	ECM1_ENST00000346569.6_Intron|ECM1_ENST00000369049.4_Missense_Mutation_p.S277L|ECM1_ENST00000470432.1_3'UTR	NM_004425.3	NP_004416.2	Q16610	ECM1_HUMAN	extracellular matrix protein 1	250	2 X approximate repeats.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|urinary_tract(1)	22	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GCCGAGTTCTCGGTCAAGACC	0.632000													5	190					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94054923	94054923	+	Splice_Site	SNP	G	G	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr7:94054923G>A	ENST00000297268.6	+	43	3254	c.2781_splice	c.e43-1	p.G928_splice		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	928					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TCTTCACAGGGCAACCCTGGG	0.493000										HNSCC(75;0.22)			4	89					0	0	1	0	0
SEL1L2	80343	broad.mit.edu	37	20	13850848	13850848	+	Splice_Site	SNP	C	C	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr20:13850848C>T	ENST00000284951.5	-	13	1180	c.1104_splice	c.e13-1	p.G369_splice	SEL1L2_ENST00000486903.1_5'UTR|SEL1L2_ENST00000378072.5_Splice_Site_p.G369_splice			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	369						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						GATTGCATTGCCCTAGAAGAG	0.338000													12	153					0	0	1	0	0
PTPDC1	138639	broad.mit.edu	37	9	96859944	96859944	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr9:96859944G>A	ENST00000375360.3	+	7	1274	c.934G>A	c.(934-936)Gaa>Aaa	p.E312K	PTPDC1_ENST00000288976.3_Missense_Mutation_p.E364K	NM_001253830.1|NM_177995.2	NP_001240759.1|NP_818931.1	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	312							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.E364K(1)|p.E312K(1)		endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	32						GGATGTGTCCGAAGGACCTGG	0.468000													4	229					0	0	1	0	0
SSX9	0	broad.mit.edu	37	X	48164214	48164214	+	Splice_Site	SNP	C	C	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chrX:48164214C>A	ENST00000376909.1	-	2	131	c.69_splice	c.e2+1	p.K23_splice	SSX9_ENST00000407081.2_Splice_Site_p.K23_splice																breast(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|stomach(1)	8						GTCACCTCACCTTTTGGATCT	0.557000													10	445					1.61879e-10	1.8115e-10	1	1	0
ACVRL1	94	broad.mit.edu	37	12	52310011	52310011	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr12:52310011G>T	ENST00000550683.1	+	7	1383	c.1282G>T	c.(1282-1284)Gtg>Ttg	p.V428L	ACVRL1_ENST00000388922.4_Missense_Mutation_p.V414L|ACVRL1_ENST00000419526.2_Missense_Mutation_p.V240L	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	414	Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CCGGACCATCGTGAATGGTGA	0.622000													3	45					1	1	1	1	0
PLEKHA6	22874	broad.mit.edu	37	1	204214034	204214034	+	Silent	SNP	C	C	A			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr1:204214034C>A	ENST00000272203.3	-	15	2446	c.2130G>T	c.(2128-2130)gtG>gtT	p.V710V	PLEKHA6_ENST00000414478.1_Silent_p.V730V	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	710										breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GAGAGCCCGACACCAGTGAAA	0.627000													3	7					0.00024832	0.000259356	1	1	0
INTS4	92105	broad.mit.edu	37	11	77629973	77629973	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr11:77629973G>C	ENST00000534064.1	-	15	1850	c.1816C>G	c.(1816-1818)Caa>Gaa	p.Q606E		NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	606					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			GGATCCTCTTGAGGTATGATG	0.493000													89	141					0	0	1	0	0
RP11-431K24.1	0	broad.mit.edu	37	1	8118037	8118037	+	RNA	DEL	T	T	-			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr1:8118037delT	ENST00000445300.1	+	0	815																											ccttccttccttccttccttc	0.438													3	4	---	---	---	---					
AGAP2	116986	broad.mit.edu	37	12	58121782	58121782	+	Frame_Shift_Del	DEL	C	C	-			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr12:58121782delC	ENST00000257897.3	-	14	1721	c.1636delG	c.(1636-1638)tcfs	p.V546fs	AGAP2_ENST00000547588.1_Frame_Shift_Del_p.V902fs|AGAP2-AS1_ENST00000542466.2_3'UTR	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	902	G domain.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						ATGGCCTGGACCCAGGCATCC	0.567													7	271	---	---	---	---					
RBM25	58517	broad.mit.edu	37	14	73572607	73572608	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr14:73572607_73572608delAG	ENST00000261973.7	+	11	1480_1481	c.1195_1196delAG	c.(1195-1197)afs	p.R399fs	RBM25_ENST00000527432.1_Frame_Shift_Del_p.R399fs	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	399	Arg-rich.|Glu-rich.|Necessary for nuclear speckle localization.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		agagcgggaaagagagagagag	0.446													7	68	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72991713	72991715	+	In_Frame_Del	DEL	CCA	CCA	-	rs4788682	by1000genomes	TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr16:72991713_72991715delCCA	ENST00000268489.5	-	2	3002_3004	c.2330_2332delTGG	c.(2329-2334)gct>g	p.VA777del	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	777	Poly-Ala.		V -> A (in dbSNP:rs4788682).		muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.V777V(1)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				gccgccgcagccaccgccgccgc	0.635													9	209	---	---	---	---					
TERF2IP	54386	broad.mit.edu	37	16	75690204	75690206	+	In_Frame_Del	DEL	GAA	GAA	-	rs140846731		TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr16:75690204_75690206delGAA	ENST00000300086.4	+	3	992_994	c.895_897delGAA	c.(895-897)del	p.E304del		NM_018975.3	NP_061848.2	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting protein	304	Asp/Glu-rich (acidic).				negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)	5						TGATgaggaggaagaagaagaag	0.424													9	164	---	---	---	---					
MIR3648	0	broad.mit.edu	37	21	9825838	9825839	+	RNA	INS	-	-	GCG	rs3052281		TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr21:9825838_9825839insGCG	ENST00000581792.1	+	0	7_8					NR_037421.1																						cggccgcgactgcggcggcggt	0.842													4	4	---	---	---	---					
XKR3	150165	broad.mit.edu	37	22	17264884	17264884	+	Frame_Shift_Del	DEL	A	A	-			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chr22:17264884delA	ENST00000331428.5	-	4	1107	c.1005delT	c.(1003-1005)atfs	p.I335fs		NM_175878.3	NP_787074.2	Q5GH77	XKR3_HUMAN	XK, Kell blood group complex subunit-related family, member 3	335						integral to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GTCTCCCGTCAATTATTTTGT	0.408													90	42	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76937477	76937480	+	Frame_Shift_Del	DEL	TCTC	TCTC	-			TCGA-S9-A6U1-01A-21D-A33T-08	TCGA-S9-A6U1-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b195ecbd-19d9-44f9-87b6-f3cee5b93490	119a0ced-acee-46e4-8534-c42b39d35197	g.chrX:76937477_76937480delTCTC	ENST00000373344.5	-	9	3482_3485	c.3268_3271delGAGA	c.(3268-3273)agfs	p.EK1090fs	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Frame_Shift_Del_p.EK1052fs	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1090					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	CACCTTTTCTTCTCTCTACCATAT	0.377			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						221	438	---	---	---	---					
