Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CBS	875	broad.mit.edu	37	21	44486353	44486353	+	Splice_Site	SNP	C	C	T			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr21:44486353C>T	ENST00000398165.3	-	5	710	c.451_splice	c.e5+1	p.G151_splice	CBS_ENST00000398158.1_Splice_Site_p.G151_splice|CBS_ENST00000352178.5_Splice_Site_p.G151_splice|CBS_ENST00000359624.3_Splice_Site_p.G151_splice|CBS_ENST00000470912.1_5'UTR|CBS_ENST00000398168.1_Splice_Site_p.G151_splice|CBS_ENST00000544202.1_Splice_Site_p.G63_splice	NM_000071.2	NP_000062.1	P35520	CBS_HUMAN	cystathionine-beta-synthase	151			G -> R (in CBSD).|Missing (in CBSD).		cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(8)	17					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	TGGCACCCACCGGTGTTCCCG	0.687000													4	68					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	rs28934578		TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr17:7578406C>T	ENST00000420246.2	-	5	656	c.524G>A	c.(523-525)cGc>cAc	p.R175H	TP53_ENST00000455263.2_Missense_Mutation_p.R175H|TP53_ENST00000269305.4_Missense_Mutation_p.R175H|TP53_ENST00000413465.2_Missense_Mutation_p.R175H|TP53_ENST00000359597.4_Missense_Mutation_p.R175H|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000445888.2_Missense_Mutation_p.R175H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	175	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> C (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934578).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(847)|p.R43H(36)|p.R82H(36)|p.R175L(19)|p.0?(8)|p.R175P(6)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*5(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652000	R175H(AU565_BREAST)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(HCC1395_BREAST)|R175H(HUCCT1_BILIARY_TRACT)|R175H(KLE_ENDOMETRIUM)|R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(LS123_LARGE_INTESTINE)|R175H(NCIH196_LUNG)|R175H(RKN_OVARY)|R175H(SKBR3_BREAST)|R175H(SKUT1_SOFT_TISSUE)|R175H(TYKNU_OVARY)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	47					0	0	1	0	0
GEM	2669	broad.mit.edu	37	8	95272441	95272441	+	Silent	SNP	A	A	G			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr8:95272441A>G	ENST00000297596.2	-	2	555	c.291T>C	c.(289-291)ggT>ggC	p.G97G	GEM_ENST00000396194.2_Silent_p.G97G	NM_005261.3	NP_005252.1	P55040	GEM_HUMAN	GTP binding protein overexpressed in skeletal muscle	97					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			TGTCATGCACACCTGCAAAGA	0.592000													28	56					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													4	47					0	0	1	0	0
RP11-564D11.3	0	broad.mit.edu	37	10	124647982	124647982	+	RNA	SNP	A	A	G			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr10:124647982A>G	ENST00000425266.1	+	0	34																											GCACACAGGCATCTAGTGGAG	0.388000													5	11					0	0	1	0	0
CIZ1	25792	broad.mit.edu	37	9	130952718	130952718	+	Missense_Mutation	SNP	A	A	G			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr9:130952718A>G	ENST00000538431.1	-	3	423	c.176T>C	c.(175-177)cTc>cCc	p.L59P	CIZ1_ENST00000277465.4_Missense_Mutation_p.L59P|CIZ1_ENST00000541172.1_Intron|CIZ1_ENST00000476727.2_Intron|CIZ1_ENST00000393608.1_Missense_Mutation_p.L59P|CIZ1_ENST00000372954.1_Missense_Mutation_p.L59P|CIZ1_ENST00000372938.5_Missense_Mutation_p.L59P|CIZ1_ENST00000357558.5_Missense_Mutation_p.L59P|CIZ1_ENST00000372948.3_Missense_Mutation_p.L59P|CIZ1_ENST00000325721.8_Missense_Mutation_p.L59P	NM_001257975.1	NP_001244904.1	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1	59						nucleus	nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|liver(1)|lung(9)|ovary(3)|prostate(2)|urinary_tract(2)	35						CTGCGGGGGGAGCCCCCTGTG	0.582000													7	18					0	0	1	0	0
WRAP73	49856	broad.mit.edu	37	1	3551833	3551833	+	Missense_Mutation	SNP	T	T	C			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr1:3551833T>C	ENST00000378322.3	-	7	687	c.629A>G	c.(628-630)gAt>gGt	p.D210G	WRAP73_ENST00000270708.7_Missense_Mutation_p.D210G			Q9P2S5	WRP73_HUMAN	WD repeat containing, antisense to TP73	210						centrosome	protein binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|pancreas(1)	12						CAACCGGCCATCCAATGAGTA	0.542000													56	51					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117663696	117663696	+	Missense_Mutation	SNP	G	G	C			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr6:117663696G>C	ENST00000368508.3	-	28	4734	c.4536C>G	c.(4534-4536)gaC>gaG	p.D1512E	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.D1506E	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1512	Fibronectin type-III 6.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GAGCTATACTGTCCTGAAATT	0.259000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								13	21					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80732944	80732944	+	Silent	SNP	T	T	C			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr12:80732944T>C	ENST00000458043.2	+	42	4929	c.4923T>C	c.(4921-4923)acT>acC	p.T1641T	OTOGL_ENST00000547103.1_Silent_p.T1629T	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TAATTACTACTCCAGCTGGAC	0.398000													4	128					0	0	1	0	0
KIAA0586	9786	broad.mit.edu	37	14	58955472	58955472	+	Missense_Mutation	SNP	T	T	G			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr14:58955472T>G	ENST00000423743.3	+	25	3787	c.3529T>G	c.(3529-3531)Tct>Gct	p.S1177A	KIAA0586_ENST00000261244.5_Missense_Mutation_p.S1145A|KIAA0586_ENST00000556134.1_Missense_Mutation_p.S1206A|KIAA0586_ENST00000538571.2_3'UTR|KIAA0586_ENST00000354386.6_Missense_Mutation_p.S1274A	NM_001244191.1|NM_001244192.1	NP_001231120.1|NP_001231121.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	1145										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GATGCCAGGTTCTGATTCATC	0.488000													3	62					0	0	1	0	0
ANKRD24	170961	broad.mit.edu	37	19	4222733	4222733	+	Missense_Mutation	SNP	G	G	A			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr19:4222733G>A	ENST00000600132.1	+	20	3514	c.3238G>A	c.(3238-3240)Gcc>Acc	p.A1080T	ANKRD24_ENST00000262970.5_Missense_Mutation_p.A1170T|ANKRD24_ENST00000318934.4_Missense_Mutation_p.A1080T	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	1080										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		GGCCGCCCTCGCCACCCCTGA	0.592000													4	16					0	0	1	0	0
TBX22	50945	broad.mit.edu	37	X	79286146	79286146	+	Missense_Mutation	SNP	G	G	A			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chrX:79286146G>A	ENST00000442340.1	+	9	1229	c.739G>A	c.(739-741)Gtc>Atc	p.V247I	TBX22_ENST00000373294.5_Missense_Mutation_p.V367I|TBX22_ENST00000373291.1_Missense_Mutation_p.V247I|TBX22_ENST00000373296.3_Missense_Mutation_p.V367I	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	367					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						CCTGCCCAATGTCAACCTGCC	0.448000													73	12					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112605177	112605177	+	Nonsense_Mutation	SNP	G	G	A			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr12:112605177G>A	ENST00000550722.1	-	72	12435	c.12040C>T	c.(12040-12042)Caa>Taa	p.Q4014*	HECTD4_ENST00000430131.2_Nonsense_Mutation_p.Q3738*|HECTD4_ENST00000377560.5_Nonsense_Mutation_p.Q3988*	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TGCAGGTCTTGCTCAGGGTCC	0.617000													64	81					0	0	1	0	0
MGARP	84709	broad.mit.edu	37	4	140188136	140188136	+	Missense_Mutation	SNP	T	T	C			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr4:140188136T>C	ENST00000398955.1	-	4	519	c.340A>G	c.(340-342)Ata>Gta	p.I114V		NM_032623.3	NP_116012.2	Q8TDB4	CD049_HUMAN	mitochondria-localized glutamic acid-rich protein	114						integral to membrane											GCTTCCACTATAAGTTCTTCT	0.438000													27	241					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11038985	11038985	+	RNA	SNP	G	G	T			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr21:11038985G>T	ENST00000470054.1	-	0	1218									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAACTTTATAGATTTGCCTCC	0.403000													40	434					5.20837e-25	5.80023e-25	1	1	0
LRRC52	440699	broad.mit.edu	37	1	165532816	165532816	+	Nonsense_Mutation	SNP	C	C	T			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr1:165532816C>T	ENST00000294818.1	+	2	987	c.697C>T	c.(697-699)Cga>Tga	p.R233*	RP11-280O1.2_ENST00000438275.1_RNA|RP11-280O1.2_ENST00000416424.1_RNA|RP11-280O1.2_ENST00000421273.1_RNA	NM_001005214.3	NP_001005214.2	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52	233	LRRCT.					integral to membrane				NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)	18	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					GAACCCACTCCGATACATGTG	0.567000													15	34					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	G	C	rs121913499		TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr2:209113113G>C	ENST00000415913.1	-	4	775	c.394C>G	c.(394-396)Cgt>Ggt	p.R132G	IDH1_ENST00000446179.1_Missense_Mutation_p.R132G|IDH1_ENST00000345146.2_Missense_Mutation_p.R132G			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132C(446)|p.R132G(125)|p.R132S(106)|p.G131_R132>VL(1)|p.R132V(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma								53	58					0	0	1	0	0
POGLUT1	56983	broad.mit.edu	37	3	119196233	119196233	+	Nonsense_Mutation	SNP	C	C	T	rs140695299	by1000genomes	TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr3:119196233C>T	ENST00000295588.4	+	4	478	c.394C>T	c.(394-396)Cga>Tga	p.R132*		NM_152305.2	NP_689518.1	Q8NBL1	PGLT1_HUMAN	protein O-glucosyltransferase 1	132						endoplasmic reticulum lumen	UDP-glucosyltransferase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(1)	16						GATCAATGTACGAGATTATCC	0.478000													40	17					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143792751	143792751	+	Missense_Mutation	SNP	T	T	A			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr7:143792751T>A	ENST00000408949.2	+	1	611	c.551T>A	c.(550-552)tTc>tAc	p.F184Y		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					ATGTCCGTATTCAAATTGGCC	0.493000													12	146					0	0	1	0	0
EFNB2	1948	broad.mit.edu	37	13	107165059	107165059	+	Missense_Mutation	SNP	T	T	G			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr13:107165059T>G	ENST00000245323.4	-	2	373	c.224A>C	c.(223-225)tAt>tCt	p.Y75S		NM_004093.3	NP_004084.1	P52799	EFNB2_HUMAN	ephrin-B2	75					cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					AACTTTATAATATTCATACTG	0.393000													7	131					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86591609	86591609	+	Nonsense_Mutation	SNP	A	A	T			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr1:86591609A>T	ENST00000370571.2	-	3	776	c.410T>A	c.(409-411)tTa>tAa	p.L137*	COL24A1_ENST00000436319.1_Nonsense_Mutation_p.L137*	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	137	TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTTAGGTAGTAATTGTACTCC	0.363000													34	46					0	0	1	0	0
DDX4	54514	broad.mit.edu	37	5	55083767	55083767	+	Missense_Mutation	SNP	G	G	T			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr5:55083767G>T	ENST00000505374.1	+	15	1203	c.1111G>T	c.(1111-1113)Gta>Tta	p.V371L	DDX4_ENST00000514278.2_Missense_Mutation_p.V351L|DDX4_ENST00000354991.5_Missense_Mutation_p.V337L|DDX4_ENST00000353507.5_Missense_Mutation_p.V337L|DDX4_ENST00000511853.1_Missense_Mutation_p.V222L	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	371	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				GTGTATTATTGTAGCACCAAC	0.388000													51	56					1.81118e-26	2.06391e-26	1	1	0
MUC16	94025	broad.mit.edu	37	19	9061576	9061576	+	Missense_Mutation	SNP	C	C	A			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr19:9061576C>A	ENST00000397910.4	-	3	26073	c.25870G>T	c.(25870-25872)Gct>Tct	p.A8624S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8626	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AATATTTCAGCTGAGGTGCTG	0.458000													4	99					1.23904e-05	1.26485e-05	1	1	0
C16orf78	123970	broad.mit.edu	37	16	49433165	49433165	+	Silent	SNP	C	C	T			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr16:49433165C>T	ENST00000299191.3	+	5	891	c.774C>T	c.(772-774)acC>acT	p.T258T		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	258										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						AGGTGTTCACCGGAATACCCA	0.522000													24	30					0	0	1	0	0
MDM2	4193	broad.mit.edu	37	12	69210669	69210669	+	Silent	SNP	A	A	C			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr12:69210669A>C	ENST00000462284.1	+	4	554	c.252A>C	c.(250-252)tcA>tcC	p.S84S	MDM2_ENST00000299252.4_Intron|MDM2_ENST00000258149.5_Silent_p.S78S|MDM2_ENST00000545204.1_Intron|MDM2_ENST00000544561.1_Intron|MDM2_ENST00000540827.1_Intron|MDM2_ENST00000258148.7_Silent_p.S84S|MDM2_ENST00000517852.1_Intron|MDM2_ENST00000478070.1_Intron|MDM2_ENST00000428863.2_Intron|MDM2_ENST00000393410.1_Intron|MDM2_ENST00000393412.3_Intron|MDM2_ENST00000393413.3_Intron|MDM2_ENST00000360430.2_Intron|MDM2_ENST00000356290.4_Intron|MDM2_ENST00000350057.5_Silent_p.S53S|MDM2_ENST00000348801.2_Intron	NM_002392.4	NP_002383.2	Q00987	MDM2_HUMAN	MDM2 oncogene, E3 ubiquitin protein ligase	78	Necessary for interaction with USP2.|SWIB.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(8)|prostate(1)|urinary_tract(1)	19	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TATATTGTTCAAATGATCTTC	0.343000			A		"""sarcoma, glioma, colorectal, other"""								33	43					0	0	1	0	0
CCKAR	886	broad.mit.edu	37	4	26483533	26483533	+	Silent	SNP	G	G	A			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr4:26483533G>A	ENST00000295589.3	-	5	1208	c.1014C>T	c.(1012-1014)taC>taT	p.Y338Y		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	338					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity	p.Y338Y(1)		NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	AGGCGGTGTCGTAGGCCCGCC	0.597000													5	96					0	0	1	0	0
AC022596.6	0	broad.mit.edu	37	17	16723981	16723981	+	RNA	SNP	C	C	T			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr17:16723981C>T	ENST00000417510.1	-	0	685																											TCGCTTGGTGCGGAAGTCATC	0.537000													9	32					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6690297	6690297	+	Missense_Mutation	SNP	C	C	T			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr12:6690297C>T	ENST00000309577.6	-	32	5069	c.4906G>A	c.(4906-4908)Gtt>Att	p.V1636I	CHD4_ENST00000544484.1_Missense_Mutation_p.V1633I|CHD4_ENST00000544040.1_Missense_Mutation_p.V1601I|CHD4_ENST00000357008.2_Missense_Mutation_p.V1608I|RP5-940J5.6_ENST00000501075.2_RNA			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1608	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GGTTCAACAACGACCTTTTCA	0.478000													68	95					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168310292	168310292	+	Missense_Mutation	SNP	C	C	T			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr5:168310292C>T	ENST00000519560.1	-	5	882	c.463G>A	c.(463-465)Ggc>Agc	p.G155S	SLIT3_ENST00000332966.8_Missense_Mutation_p.G155S|SLIT3_ENST00000404867.3_Missense_Mutation_p.G155S	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	155					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCGGTGATGCCGCGGAACGCC	0.502000													23	28					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10212891	10212891	+	Missense_Mutation	SNP	C	C	T			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr17:10212891C>T	ENST00000418404.3	-	33	5076	c.4913G>A	c.(4912-4914)cGc>cAc	p.R1638H	MYH13_ENST00000570743.1_Missense_Mutation_p.R1638H|MYH13_ENST00000252172.4_Missense_Mutation_p.R1638H			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1638					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TGCCATCTGGCGGTTGGAGTG	0.622000													11	22					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43038404	43038404	+	Missense_Mutation	SNP	G	G	C			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr15:43038404G>C	ENST00000267890.6	-	15	3432	c.3324C>G	c.(3322-3324)ttC>ttG	p.F1108L		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1108					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CCAGGCGGGAGAAAAGGTCTG	0.418000													19	9					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24372736	24372736	+	Missense_Mutation	SNP	G	G	A	rs150191653		TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr16:24372736G>A	ENST00000005284.3	+	4	1702	c.500G>A	c.(499-501)cGt>cAt	p.R167H		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	167					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		CCCGGGCAGCGTGACTCCAAA	0.443000													5	168					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600725	29600725	+	Missense_Mutation	SNP	G	G	T			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr13:29600725G>T	ENST00000431530.3	+	1	1978	c.1920G>T	c.(1918-1920)aaG>aaT	p.K640N		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	630						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CAGAAACTAAGCCCATCATTA	0.542000													14	27					2.61681e-11	2.78748e-11	1	1	0
FAM129A	116496	broad.mit.edu	37	1	184777346	184777346	+	Silent	SNP	A	A	G			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr1:184777346A>G	ENST00000367511.3	-	10	1390	c.1197T>C	c.(1195-1197)ctT>ctC	p.L399L	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	399					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						AATGCAGCGGAAGATTCATAA	0.453000													7	55					0	0	1	0	0
GPRC6A	0	broad.mit.edu	37	6	117130667	117130667	+	Missense_Mutation	SNP	C	C	A			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr6:117130667C>A	ENST00000310357.3	-	2	329	c.308G>T	c.(307-309)tGt>tTt	p.C103F	GPRC6A_ENST00000530250.1_Missense_Mutation_p.C103F|GPRC6A_ENST00000368549.3_Missense_Mutation_p.C103F	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	103					response to amino acid stimulus		G-protein coupled receptor activity	p.C103F(1)		autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		GACTTCTGTACAAGTGTCATA	0.413000													30	39					1.16021e-09	1.20958e-09	1	1	0
SNX25	83891	broad.mit.edu	37	4	186263216	186263216	+	Nonsense_Mutation	SNP	G	G	A			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr4:186263216G>A	ENST00000504273.1	+	12	1935	c.1641G>A	c.(1639-1641)tgG>tgA	p.W547*	SNX25_ENST00000512853.1_3'UTR|SNX25_ENST00000264694.8_Nonsense_Mutation_p.W547*			Q9H3E2	SNX25_HUMAN	sorting nexin 25	547	PX.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		CTAAGAACTGGACGGTCCCCA	0.433000													58	99					0	0	1	0	0
OR10A4	283297	broad.mit.edu	37	11	6898108	6898108	+	Missense_Mutation	SNP	T	T	C			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr11:6898108T>C	ENST00000379829.2	+	1	253	c.230T>C	c.(229-231)gTc>gCc	p.V77A		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TTCAACTTGGTCATTGTGCCC	0.458000													6	89					0	0	1	0	0
DNAH12	201625	broad.mit.edu	37	3	57509313	57509313	+	Frame_Shift_Del	DEL	T	T	-			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr3:57509313delT	ENST00000351747.2	-	4	456	c.276delA	c.(274-276)aafs	p.K92fs	DNAH12_ENST00000311202.6_Frame_Shift_Del_p.K92fs|DNAH12_ENST00000389536.4_Frame_Shift_Del_p.K92fs	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	92	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.G93fs*7(2)		breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						AACTCACTCCTTTTTTTTTCA	0.254													7	57	---	---	---	---					
DNAH11	8701	broad.mit.edu	37	7	21781718	21781718	+	Frame_Shift_Del	DEL	C	C	-			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr7:21781718delC	ENST00000328843.6	+	50	8140	c.8109delC	c.(8107-8109)aafs	p.N2703fs	DNAH11_ENST00000409508.3_Frame_Shift_Del_p.N2696fs			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2703	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGATGTGTAACTTTTTACCCA	0.418									Kartagener syndrome				36	74	---	---	---	---					
GTF2IRD1P1	0	broad.mit.edu	37	7	66304731	66304731	+	RNA	DEL	T	T	-			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr7:66304731delT	ENST00000457166.1	-	0	189					NR_003934.1																						TTTCTTTCCCttttttttttt	0.512													3	5	---	---	---	---					
SLK	9748	broad.mit.edu	37	10	105765409	105765409	+	Frame_Shift_Del	DEL	A	A	-			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr10:105765409delA	ENST00000369755.3	+	10	2985	c.2440delA	c.(2440-2442)cafs	p.T814fs	SLK_ENST00000335753.4_Frame_Shift_Del_p.T814fs	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	814					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AAAGATAGTTACAGATAGTGA	0.343													33	35	---	---	---	---					
PHLDB1	23187	broad.mit.edu	37	11	118513008	118513021	+	Frame_Shift_Del	DEL	CAGTGGTACCAGGA	CAGTGGTACCAGGA	-			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr11:118513008_118513021delCAGTGGTACCAGGA	ENST00000361417.2	+	14	3184_3197	c.2773_2786delCAGTGGTACCAGGA	c.(2773-2787)gfs	p.QWYQE925fs	PHLDB1_ENST00000534672.1_Intron|PHLDB1_ENST00000527898.1_Intron|PHLDB1_ENST00000356063.5_Intron|PHLDB1_ENST00000524713.1_Frame_Shift_Del_p.QWYQE68fs	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	925										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		AGACTTAGAGCAGTGGTACCAGGAGCTGATGGCC	0.640													24	102	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													3	5	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7579716	7579716	+	Frame_Shift_Del	DEL	G	G	-			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr17:7579716delG	ENST00000420246.2	-	3	212	c.80delC	c.(79-81)ctfs	p.P27fs	TP53_ENST00000359597.4_Frame_Shift_Del_p.P27fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.P27fs|TP53_ENST00000413465.2_Frame_Shift_Del_p.P27fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.P27fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.P27fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	27	Interaction with HRMT1L2.|Transcription activation (acidic).				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.P27fs*17(4)|p.P27fs*50(1)|p.P13fs*18(1)|p.L26fs*11(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTGTTTTCAGGAAGTCTGAA	0.617		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			37	37	---	---	---	---					
CD79A	0	broad.mit.edu	37	19	42384999	42384999	+	Frame_Shift_Del	DEL	G	G	-			TCGA-WY-A85C-01A-11D-A36O-08	TCGA-WY-A85C-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a54624-8f3c-4b1b-86d5-61ba2b23301e	6b10639c-71dc-4e9e-9b88-65335e63c029	g.chr19:42384999delG	ENST00000221972.3	+	5	818	c.633delG	c.(631-633)cafs	p.Q211fs	CD79A_ENST00000444740.2_Frame_Shift_Del_p.Q173fs	NM_001783.3|NM_021601.3	NP_001774.1|NP_067612.1	P11912	CD79A_HUMAN	CD79a molecule, immunoglobulin-associated alpha	211					B cell differentiation|B cell proliferation|B cell receptor signaling pathway	B cell receptor complex|external side of plasma membrane|integral to membrane|membrane raft|multivesicular body	transmembrane receptor activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	11						GCACCTACCAGGATGTGGGCA	0.627			"""O, S"""		DLBCL								2	4	---	---	---	---					
